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Conserved domains on  [gi|1720394752|ref|XP_030106658|]
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U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [Mus musculus]

Protein Classification

SART-1 family protein( domain architecture ID 12043325)

SART-1 family protein similar to human U4/U6.U5 tri-snRNP-associated protein 1, also called squamous cell carcinoma antigen recognized by T-cells 1 (SART-1), that plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 7-601 7.82e-124

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


:

Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 378.61  E-value: 7.82e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752   7 EELREKLAAAKEKRLLNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFEQR 86
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752  87 RQDLYSARDLQGLTVEHAIDSFREGETVVLTLKDKGVLQD-GEDVLVNVNMVDKERADKNVELRKKKPDYLPYAEDESVd 165
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLLDeEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 166 dlaqQKPRSILAKYDEELEG-ERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLSSVGPRLASEYLSPEEMVTFKKT 244
Cdd:pfam03343 148 ----EGEKGILSKYDEEIDGkKKKKGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKFKKP 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 245 KRRVKKIRKKEKEvimRADDLLPlgdqtqdgdfgsrlrgrgrrrvpeveeealedeekDPVAQPPPSDDTRVENMDISDE 324
Cdd:pfam03343 224 KKKKKKKTRKKAK---KDDDLLI-----------------------------------LFPGEADLGLPSDDDDMDVDSE 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 325 edGGALPPGSPEGLEEDEAELELQKQLEKGRRLRQLQQLQqlrdsgEKVLEIVKKLESrQRGWEEEEDPERKGTIVFNAT 404
Cdd:pfam03343 266 --PIGVERLTRDVIENFVDDDDLQAALARQRRAALKKRKK------LRPEDIARQLKE-EREEEEEDEEEEDGGLVIDET 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 405 SEFCRTLGEIPTYGLAGNREEQ---EELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQDFSAS-------STT 474
Cdd:pfam03343 337 SEFVRNLGAIPTYERAGNRRKPvpvSPVADEEDEEEDMFEEDGDVDMEDESYEDAEEEEAEEEAREEEESdedladiTGT 416

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 475 ILDEEPIVNRGLAAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKY 533
Cdd:pfam03343 417 GLEEEPTVSQGLGATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEY 496

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720394752 534 SRREEYR------GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEE 601
Cdd:pfam03343 497 ARRENRQreqqeaRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEE 569
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 7-601 7.82e-124

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 378.61  E-value: 7.82e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752   7 EELREKLAAAKEKRLLNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFEQR 86
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752  87 RQDLYSARDLQGLTVEHAIDSFREGETVVLTLKDKGVLQD-GEDVLVNVNMVDKERADKNVELRKKKPDYLPYAEDESVd 165
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLLDeEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 166 dlaqQKPRSILAKYDEELEG-ERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLSSVGPRLASEYLSPEEMVTFKKT 244
Cdd:pfam03343 148 ----EGEKGILSKYDEEIDGkKKKKGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKFKKP 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 245 KRRVKKIRKKEKEvimRADDLLPlgdqtqdgdfgsrlrgrgrrrvpeveeealedeekDPVAQPPPSDDTRVENMDISDE 324
Cdd:pfam03343 224 KKKKKKKTRKKAK---KDDDLLI-----------------------------------LFPGEADLGLPSDDDDMDVDSE 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 325 edGGALPPGSPEGLEEDEAELELQKQLEKGRRLRQLQQLQqlrdsgEKVLEIVKKLESrQRGWEEEEDPERKGTIVFNAT 404
Cdd:pfam03343 266 --PIGVERLTRDVIENFVDDDDLQAALARQRRAALKKRKK------LRPEDIARQLKE-EREEEEEDEEEEDGGLVIDET 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 405 SEFCRTLGEIPTYGLAGNREEQ---EELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQDFSAS-------STT 474
Cdd:pfam03343 337 SEFVRNLGAIPTYERAGNRRKPvpvSPVADEEDEEEDMFEEDGDVDMEDESYEDAEEEEAEEEAREEEESdedladiTGT 416

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 475 ILDEEPIVNRGLAAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKY 533
Cdd:pfam03343 417 GLEEEPTVSQGLGATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEY 496

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720394752 534 SRREEYR------GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEE 601
Cdd:pfam03343 497 ARRENRQreqqeaRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEE 569
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 7-601 7.82e-124

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 378.61  E-value: 7.82e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752   7 EELREKLAAAKEKRLLNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFEQR 86
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752  87 RQDLYSARDLQGLTVEHAIDSFREGETVVLTLKDKGVLQD-GEDVLVNVNMVDKERADKNVELRKKKPDYLPYAEDESVd 165
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLLDeEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 166 dlaqQKPRSILAKYDEELEG-ERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLSSVGPRLASEYLSPEEMVTFKKT 244
Cdd:pfam03343 148 ----EGEKGILSKYDEEIDGkKKKKGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKFKKP 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 245 KRRVKKIRKKEKEvimRADDLLPlgdqtqdgdfgsrlrgrgrrrvpeveeealedeekDPVAQPPPSDDTRVENMDISDE 324
Cdd:pfam03343 224 KKKKKKKTRKKAK---KDDDLLI-----------------------------------LFPGEADLGLPSDDDDMDVDSE 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 325 edGGALPPGSPEGLEEDEAELELQKQLEKGRRLRQLQQLQqlrdsgEKVLEIVKKLESrQRGWEEEEDPERKGTIVFNAT 404
Cdd:pfam03343 266 --PIGVERLTRDVIENFVDDDDLQAALARQRRAALKKRKK------LRPEDIARQLKE-EREEEEEDEEEEDGGLVIDET 336

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 405 SEFCRTLGEIPTYGLAGNREEQ---EELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQDFSAS-------STT 474
Cdd:pfam03343 337 SEFVRNLGAIPTYERAGNRRKPvpvSPVADEEDEEEDMFEEDGDVDMEDESYEDAEEEEAEEEAREEEESdedladiTGT 416

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720394752 475 ILDEEPIVNRGLAAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKY 533
Cdd:pfam03343 417 GLEEEPTVSQGLGATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEY 496

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720394752 534 SRREEYR------GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEE 601
Cdd:pfam03343 497 ARRENRQreqqeaRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEE 569
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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