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Conserved domains on  [gi|1720390315|ref|XP_030105700|]
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uncharacterized protein LOC319615 isoform X3 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-446 2.77e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 283 KPYKCGKCEKCFTHKGDLRSHQR--IHTGE--KPYKCSE--CDKCFTHKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSL 356
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 357 -------SIHQIIHTEEKPYRCSGCDKIFNHKGD--LRNHQRIHTGQKPY--KCSECDKCFVHKYSLSIHQRIHTgEKPY 425
Cdd:COG5048   368 nneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                         170       180
                  ....*....|....*....|.
gi 1720390315 426 KCNECNEFFRYKCSLRTHQKM 446
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.18e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 215 DLRIHQRIHTGEKPYKCIECDKSFTQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-184 6.73e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390315 160 LRQHQIIHTGEKPYRCSQCDKCFSQ 184
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 7.21e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 243 HLIIHQRIHTGEKPYKCSECDKCFTQ 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-446 2.77e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 283 KPYKCGKCEKCFTHKGDLRSHQR--IHTGE--KPYKCSE--CDKCFTHKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSL 356
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 357 -------SIHQIIHTEEKPYRCSGCDKIFNHKGD--LRNHQRIHTGQKPY--KCSECDKCFVHKYSLSIHQRIHTgEKPY 425
Cdd:COG5048   368 nneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                         170       180
                  ....*....|....*....|.
gi 1720390315 426 KCNECNEFFRYKCSLRTHQKM 446
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 327 SLRSHQRIHTGEKPYKCSECDKCFTH 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 215 DLRIHQRIHTGEKPYKCIECDKSFTQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-184 6.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390315 160 LRQHQIIHTGEKPYRCSQCDKCFSQ 184
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 7.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 243 HLIIHQRIHTGEKPYKCSECDKCFTQ 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-446 2.77e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 283 KPYKCGKCEKCFTHKGDLRSHQR--IHTGE--KPYKCSE--CDKCFTHKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSL 356
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 357 -------SIHQIIHTEEKPYRCSGCDKIFNHKGD--LRNHQRIHTGQKPY--KCSECDKCFVHKYSLSIHQRIHTgEKPY 425
Cdd:COG5048   368 nneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                         170       180
                  ....*....|....*....|.
gi 1720390315 426 KCNECNEFFRYKCSLRTHQKM 446
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-378 2.72e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 227 KPYKCIECDKSFTQKGHLIIHQR--IHTGE--KPYKCSE--CDKCFTQKCSLTIHQRIHTGEKPYKC--GKCEKCFTHKG 298
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 299 DLRSHQRI--HTGEKPYKCSECDKCFT-------HKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSLSIHQIIHTEEKPY 369
Cdd:COG5048   368 NNEPPQSLqqYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*....
gi 1720390315 370 RCSGCDKIF 378
Cdd:COG5048   448 LCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 309-387 3.16e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 309 GEKPYKCS--ECDKCFTHKRSLRSHqRIHtgekpykcSECDKCFTHKRSLSIHQIIHTEEKPYRCSGCDKIFNHKGDLRN 386
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390315 387 H 387
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 253-331 1.68e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 253 GEKPYKCS--ECDKCFTQKCSLTIHqRIHtgekpykcGKCEKCFTHKGDLRSHQRIHTGEKPYKCSECDKCFTHKRSLRS 330
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390315 331 H 331
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 327 SLRSHQRIHTGEKPYKCSECDKCFTH 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 1.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 299 DLRSHQRIHTGEKPYKCSECDKCFTH 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 215 DLRIHQRIHTGEKPYKCIECDKSFTQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 2.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 383 DLRNHQRIHTGQKPYKCSECDKCFVH 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-184 6.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390315 160 LRQHQIIHTGEKPYRCSQCDKCFSQ 184
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 7.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390315 243 HLIIHQRIHTGEKPYKCSECDKCFTQ 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-284 9.71e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390315 227 KPYKCIECDKSFTQKGHLIIHQRIHTGEKPYKCS--ECDKCFTQKCSLTIHQRIHTGEKP 284
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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