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Conserved domains on  [gi|1720375917|ref|XP_030103297|]
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centrosomal protein of 72 kDa isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-95 1.14e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917   6 LKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYRLFVVHMLPKLRQL 84
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVL 200

                          90
                  ....*....|.
gi 1720375917  85 DDRPVRESERK 95
Cdd:cd21340   201 DGKEITDTERQ 211
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
427-582 4.05e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 427 LSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALTLQIT 505
Cdd:COG4372    18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQlQAAQAELA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 506 GLQASMKQLSGEVVELKQHVEH----YDKIQELTQMLQESHSSL---VSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFK 578
Cdd:COG4372    98 QAQEELESLQEEAEELQEELEElqkeRQDLEQQRKQLEAQIAELqseIAEREEELKELEEQLESLQEELAALEQELQALS 177


                  ....
gi 1720375917 579 KTTA 582
Cdd:COG4372   178 EAEA 181
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-95 1.14e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917   6 LKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYRLFVVHMLPKLRQL 84
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVL 200

                          90
                  ....*....|.
gi 1720375917  85 DDRPVRESERK 95
Cdd:cd21340   201 DGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
2-101 2.41e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917   2 HLTALKSLDLSRNSLVSL-EGI-QYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVkNESDYRLFVVHMLP 79
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVP 140

                          90       100
                  ....*....|....*....|..
gi 1720375917  80 KLRQLDDRPVRESERKASQLHF 101
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-63 1.38e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.38e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375917   2 HLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHtllELQDVDFRLNPV 63
Cdd:COG4886   226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNNQL 284
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
427-582 4.05e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 427 LSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALTLQIT 505
Cdd:COG4372    18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQlQAAQAELA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 506 GLQASMKQLSGEVVELKQHVEH----YDKIQELTQMLQESHSSL---VSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFK 578
Cdd:COG4372    98 QAQEELESLQEEAEELQEELEElqkeRQDLEQQRKQLEAQIAELqseIAEREEELKELEEQLESLQEELAALEQELQALS 177


                  ....
gi 1720375917 579 KTTA 582
Cdd:COG4372   178 EAEA 181
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 68-85 1.25e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.13  E-value: 1.25e-03
                           10
                   ....*....|....*...
gi 1720375917   68 SDYRLFVVHMLPKLRQLD 85
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 430-540 1.98e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 430 ENKTLQSR---LAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTstaltlQITG 506
Cdd:TIGR04523 212 KNKSLESQiseLKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNK------KIKE 285

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720375917 507 LQASMKQLSGEVVELKQhvehyDKIQELTQMLQE 540
Cdd:TIGR04523 286 LEKQLNQLKSEISDLNN-----QKEQDWNKELKS 314
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 394-511 5.49e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 39.28  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 394 EAFLAQAKHVLSSLQEF-TATRD------------SSALEKEGIGYLSLENKTLQSRLAEQQQQYTAtvtKMTAELNNTK 460
Cdd:cd22656   131 KKYQDKAAKVVDKLTDFeNQTEKdqtaletlekalKDLLTDEGGAIARKEIKDLQKELEKLNEEYAA---KLKAKIDELK 207

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720375917 461 RELDTLRQHLdksleenshlksllynvKKEVKTADTSTALTLQITGLQASM 511
Cdd:cd22656   208 ALIADDEAKL-----------------AAALRLIADLTAADTDLDNLLALI 241
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-95 1.14e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917   6 LKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFR-LHTLLELQDVDFRLNPVVKNeSDYRLFVVHMLPKLRQL 84
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVL 200

                          90
                  ....*....|.
gi 1720375917  85 DDRPVRESERK 95
Cdd:cd21340   201 DGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
2-101 2.41e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917   2 HLTALKSLDLSRNSLVSL-EGI-QYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVkNESDYRLFVVHMLP 79
Cdd:pfam14580  62 LLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVP 140

                          90       100
                  ....*....|....*....|..
gi 1720375917  80 KLRQLDDRPVRESERKASQLHF 101
Cdd:pfam14580 141 QLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-63 1.38e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.38e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720375917   2 HLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHtllELQDVDFRLNPV 63
Cdd:COG4886   226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-53 1.31e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 1.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720375917   3 LTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVF-RLHTLLEL 53
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLgNLTNLEEL 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-53 2.87e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 2.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720375917   3 LTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVFRLHTLLEL 53
Cdd:COG4886   204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-53 1.19e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720375917   2 HLTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSL-AEVFRLHTLLEL 53
Cdd:COG4886   134 NLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKEL 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-85 1.24e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917   3 LTALKSLDLSRNSLVSL-EGIQYLVSLESLNLYYNCISSLAEVfrLHTLLELQDVDFRLNPVVKnesdyrLFVVHMLPKL 81
Cdd:COG4886   181 LTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD------LPELGNLTNL 252


                  ....
gi 1720375917  82 RQLD 85
Cdd:COG4886   253 EELD 256
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
427-582 4.05e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 427 LSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALTLQIT 505
Cdd:COG4372    18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQlQAAQAELA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 506 GLQASMKQLSGEVVELKQHVEH----YDKIQELTQMLQESHSSL---VSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFK 578
Cdd:COG4372    98 QAQEELESLQEEAEELQEELEElqkeRQDLEQQRKQLEAQIAELqseIAEREEELKELEEQLESLQEELAALEQELQALS 177


                  ....
gi 1720375917 579 KTTA 582
Cdd:COG4372   178 EAEA 181
LRR_8 pfam13855
Leucine rich repeat;
6-41 8.91e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 8.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720375917   6 LKSLDLSRNSLVSLEG--IQYLVSLESLNLYYNCISSL 41
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTL 40
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 4-43 1.20e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720375917   4 TALKSLDLSRNSLVSLEGIQYLVSLESLNLYYN-CISSLAE 43
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSD 41
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 68-85 1.25e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.13  E-value: 1.25e-03
                           10
                   ....*....|....*...
gi 1720375917   68 SDYRLFVVHMLPKLRQLD 85
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 430-540 1.98e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 430 ENKTLQSR---LAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTstaltlQITG 506
Cdd:TIGR04523 212 KNKSLESQiseLKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNK------KIKE 285

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720375917 507 LQASMKQLSGEVVELKQhvehyDKIQELTQMLQE 540
Cdd:TIGR04523 286 LEKQLNQLKSEISDLNN-----QKEQDWNKELKS 314
LRR_8 pfam13855
Leucine rich repeat;
2-36 4.66e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720375917   2 HLTALKSLDLSRNSLVSLEG--IQYLVSLESLNLYYN 36
Cdd:pfam13855  23 GLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 394-511 5.49e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 39.28  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 394 EAFLAQAKHVLSSLQEF-TATRD------------SSALEKEGIGYLSLENKTLQSRLAEQQQQYTAtvtKMTAELNNTK 460
Cdd:cd22656   131 KKYQDKAAKVVDKLTDFeNQTEKdqtaletlekalKDLLTDEGGAIARKEIKDLQKELEKLNEEYAA---KLKAKIDELK 207

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720375917 461 RELDTLRQHLdksleenshlksllynvKKEVKTADTSTALTLQITGLQASM 511
Cdd:cd22656   208 ALIADDEAKL-----------------AAALRLIADLTAADTDLDNLLALI 241
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
420-570 5.92e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 39.61  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 420 EKEGIGYLSLENKTLQSRLAEQQQQYTATvtkmTAELNNTKRELDTLRQHLDKSLEENShlksllynvkkEVKTADTSTA 499
Cdd:COG3206   203 QKNGLVDLSEEAKLLLQQLSELESQLAEA----RAELAEAEARLAALRAQLGSGPDALP-----------ELLQSPVIQQ 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720375917 500 LTLQITGLQASMKQLSG-------EVVELKQHVEHYDK-IQELTQMLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQM 570
Cdd:COG3206   268 LRAQLAELEAELAELSArytpnhpDVIALRAQIAALRAqLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL 346
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 426-571 6.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375917 426 YLSLENKTLQSRLAEQQQQYTATVTKM---TAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTS-TALT 501
Cdd:COG1196   229 LLLLKLRELEAELEELEAELEELEAELeelEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDiARLE 308

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720375917 502 LQITGLQASMKQLSGEVVELKQHVE-HYDKIQELTQMLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQMR 571
Cdd:COG1196   309 ERRRELEERLEELEEELAELEEELEeLEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-41 6.88e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 6.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720375917   3 LTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSL 41
Cdd:COG4886   249 LTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-54 7.96e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 7.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720375917   2 HLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHTLLELQ 54
Cdd:cd21340    44 FLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELH 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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