NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720367788|ref|XP_030102253|]
View 

regulatory-associated protein of mTOR isoform X5 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-796 7.94e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 7.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 501 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 577
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 578 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 657
Cdd:cd00200    82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 658 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 735
Cdd:cd00200   153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720367788 736 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 796
Cdd:cd00200   228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
HEAT COG1413
HEAT repeat [General function prediction only];
37-144 5.61e-09

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.41  E-value: 5.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788  37 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 116
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                          90       100
                  ....*....|....*....|....*...
gi 1720367788 117 nvammLAQLINDGSPMVRKELVVALSHL 144
Cdd:COG1413   114 -----LLEALKDPDWEVRRAAARALGRL 136
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-796 7.94e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 7.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 501 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 577
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 578 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 657
Cdd:cd00200    82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 658 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 735
Cdd:cd00200   153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720367788 736 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 796
Cdd:cd00200   228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
512-805 8.25e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 512 IAVADKD-SICFWDWEKGEKLDYF--HNGnprytRVTAMEYL-NGQdcsLLLTATDDGAIRVWknfaDLEKNPEMVTawq 587
Cdd:COG2319   135 LASGSADgTVRLWDLATGKLLRTLtgHSG-----AVTSVAFSpDGK---LLASGSDDGTVRLW----DLATGKLLRT--- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 588 glsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY 667
Cdd:COG2319   200 -----LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 668 DRRmalSECRVMTYREHTAWVVKAYLqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDIHPQANLIACG 745
Cdd:COG2319   274 DLA---TGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASG 348

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720367788 746 SMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 805
Cdd:COG2319   349 SDDGTVRLWDlATGELLRTLT-------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
HEAT COG1413
HEAT repeat [General function prediction only];
37-144 5.61e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.41  E-value: 5.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788  37 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 116
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                          90       100
                  ....*....|....*....|....*...
gi 1720367788 117 nvammLAQLINDGSPMVRKELVVALSHL 144
Cdd:COG1413   114 -----LLEALKDPDWEVRRAAARALGRL 136
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 37-142 1.58e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788  37 LEQL-SDPHPLLRQWVAICLGRIwqNFDSARwcgvrdsahEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTID 115
Cdd:pfam13646   5 LQALlRDPDPEVRAAAIRALGRI--GDPEAV---------PALLELLKDEDPAVRRAAAEALG--------KIGDPEALP 65

                          90       100
                  ....*....|....*....|....*..
gi 1720367788 116 HnvamMLAQLINDGSPMVRKELVVALS 142
Cdd:pfam13646  66 A----LLELLRDDDDDVVRAAAAEALA 88
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-796 7.94e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 7.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 501 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 577
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 578 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 657
Cdd:cd00200    82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 658 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 735
Cdd:cd00200   153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720367788 736 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 796
Cdd:cd00200   228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 597-804 1.53e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 1.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 597 RGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRmalSEC 676
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 677 RVMTYREHTAWVvkAYLQKHPEGHIVSVS-VNGDVRFFDPRMPESVNVMQ-IVKGLTALDIHPQANLIACGSMNQFTAIY 754
Cdd:cd00200    85 CVRTLTGHTSYV--SSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720367788 755 NG-NGELINNIKYYDGFmgqrvgaISCLAFHPHWPHLAVGSNDYYISVYSV 804
Cdd:cd00200   163 DLrTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
512-805 8.25e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 8.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 512 IAVADKD-SICFWDWEKGEKLDYF--HNGnprytRVTAMEYL-NGQdcsLLLTATDDGAIRVWknfaDLEKNPEMVTawq 587
Cdd:COG2319   135 LASGSADgTVRLWDLATGKLLRTLtgHSG-----AVTSVAFSpDGK---LLASGSDDGTVRLW----DLATGKLLRT--- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 588 glsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY 667
Cdd:COG2319   200 -----LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 668 DRRmalSECRVMTYREHTAWVVKAYLqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDIHPQANLIACG 745
Cdd:COG2319   274 DLA---TGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASG 348

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720367788 746 SMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 805
Cdd:COG2319   349 SDDGTVRLWDlATGELLRTLT-------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
493-805 4.69e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 4.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 493 LNRNPGVPSVVKFHPFTPCIAVADKD-SICFWDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRV 569
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLLLRTLtgHTGAVRSVAFSP-------DGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 570 WknfaDLEKNPEMVTawqglsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCD 649
Cdd:COG2319   147 W----DLATGKLLRT--------LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 650 SHRSLIVAGLGDGSIRVYDrrMALSECrVMTYREHTAWVVK-AYlqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQIV 727
Cdd:COG2319   214 PDGKLLASGSADGTVRLWD--LATGKL-LRTLTGHSGSVRSvAF---SPDGrLLASGSADGTVRLWDLATGELLRTLTGH 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 728 KG-LTALDIHPQANLIACGSMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 805
Cdd:COG2319   288 SGgVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLT-------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 503-714 5.93e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 5.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 503 VKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNprytrVTAMEYLngQDCSLLLTATDDGAIRVWknfaDLEKN 579
Cdd:cd00200    57 VAASADGTYLASGSSDKTIRlWDLETGECVRTLtgHTSY-----VSSVAFS--PDGRILSSSSRDKTIKVW----DVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 580 pEMVTAWQGLSDmlpttrgAGMVVDWEQETGLLMSSGDVRIVRIWDT--------------------------------- 626
Cdd:cd00200   126 -KCLTTLRGHTD-------WVNSVAFSPDGTFVASSSQDGTIKLWDLrtgkcvatltghtgevnsvafspdgekllssss 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 627 DRETKVQDIPTGADSC--------VTSLSCDSHRSLIVAGLGDGSIRVYDRRMAlsECrVMTYREHTAWVVKAYLqkHPE 698
Cdd:cd00200   198 DGTIKLWDLSTGKCLGtlrghengVNSVAFSPDGYLLASGSEDGTIRVWDLRTG--EC-VQTLSGHTNSVTSLAW--SPD 272

                         250
                  ....*....|....*..
gi 1720367788 699 GH-IVSVSVNGDVRFFD 714
Cdd:cd00200   273 GKrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
499-805 3.58e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 499 VPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMeylngQDCSLLLTATDDGAIRVWknfaDLEk 578
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLW----DLA- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 579 NPEMVTAWQGLSDMLPTtrgagmvVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAG 658
Cdd:COG2319   109 TGLLLRTLTGHTGAVRS-------VAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLASG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 659 LGDGSIRVYDrrmALSECRVMTYREHTAWVVK-AYlqkHPEGH-IVSVSVNGDVRFFDprmPESVNVMQIVKG----LTA 732
Cdd:COG2319   181 SDDGTVRLWD---LATGKLLRTLTGHTGAVRSvAF---SPDGKlLASGSADGTVRLWD---LATGKLLRTLTGhsgsVRS 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720367788 733 LDIHPQANLIACGSMNQFTAIYN-GNGELInnikyydGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 805
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDlATGELL-------RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
HEAT COG1413
HEAT repeat [General function prediction only];
37-144 5.61e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.41  E-value: 5.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788  37 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 116
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                          90       100
                  ....*....|....*....|....*...
gi 1720367788 117 nvammLAQLINDGSPMVRKELVVALSHL 144
Cdd:COG1413   114 -----LLEALKDPDWEVRRAAARALGRL 136
WD40 COG2319
WD40 repeat [General function prediction only];
584-805 1.22e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 584 TAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQdIPTGADSCVTSLSCDSHRSLIVAGLGDGS 663
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-TLLGHTAAVLSVAFSPDGRLLASASADGT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 664 IRVYDrrmALSECRVMTYREHTAWVVKAYLqkHPEGH-IVSVSVNGDVRFFDPRMPESVNVMQIVKG-LTALDIHPQANL 741
Cdd:COG2319   102 VRLWD---LATGLLLRTLTGHTGAVRSVAF--SPDGKtLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAFSPDGKL 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720367788 742 IACGSMNQFTAIYN-GNGELINNIKYYDgfmgqrvGAISCLAFHPHWPHLAVGSNDYYISVYSVE 805
Cdd:COG2319   177 LASGSDDGTVRLWDlATGKLLRTLTGHT-------GAVRSVAFSPDGKLLASGSADGTVRLWDLA 234
HEAT COG1413
HEAT repeat [General function prediction only];
37-144 1.79e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.78  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788  37 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 116
Cdd:COG1413    22 IAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALG--------RIGDPEAVPA 82

                          90       100
                  ....*....|....*....|....*...
gi 1720367788 117 nvammLAQLINDGSPMVRKELVVALSHL 144
Cdd:COG1413    83 -----LIAALKDEDPEVRRAAAEALGRL 105
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 512-807 2.78e-07

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 53.39  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 512 IAVADKD-SICFWDWEKGEKLDYFHNGNPRYT-----RVTAMEYLNGQdcslLLTATDDGAIRVWKNFADLEKNPEmVTA 585
Cdd:cd22857    47 LAVARKNgTVEVLDPENGDLLASFSDSEPATKlseedHFVGLHLFSGT----LLTCTSKGSLRSTKLPDDSTASSS-PTA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 586 WQGLSDMLPTTRGagmvvdwEQETGLLMSSGDVRIVRIWDTdrETKVQDI---------------PTgadsCVTS---LS 647
Cdd:cd22857   122 WVCLGGNLLCMRV-------DPNENYFAFGGKEVELNVWDL--EEKPGKIwraknvpndslglrvPV----WVTDltfLS 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 648 CDSHRSlIVAGLGDGSIRVYD----RRmalsecRVM--TYREHTAWVVkaylQKHPEGHIVSVSVN-GDVRFFDPRmpes 720
Cdd:cd22857   189 KDDHRK-IVTGTGYHQVRLYDtraqRR------PVVsvDFGETPIKAV----AEDPDGHTVYVGDTsGDLASIDLR---- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788 721 vnvmqivkgltaldihpqanliacgsmnqftaiyngNGELINNikyYDGFMGqrvGAISCLAFHPHWPHLAVGSNDYYIS 800
Cdd:cd22857   254 ------------------------------------TGKLLGC---FKGKCG---GSIRSIARHPELPLIASCGLDRYLR 291


                  ....*..
gi 1720367788 801 VYSVEKR 807
Cdd:cd22857   292 IWDTETR 298
HEAT COG1413
HEAT repeat [General function prediction only];
33-98 1.31e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.39  E-value: 1.31e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720367788  33 IAICLEQLSDPHPLLRQWVAICLGRIWqnfdsarwcgvRDSAHEKLYSLLSDPIPEVRCAAVFALG 98
Cdd:COG1413    80 VPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALG 134
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 37-142 1.58e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720367788  37 LEQL-SDPHPLLRQWVAICLGRIwqNFDSARwcgvrdsahEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTID 115
Cdd:pfam13646   5 LQALlRDPDPEVRAAAIRALGRI--GDPEAV---------PALLELLKDEDPAVRRAAAEALG--------KIGDPEALP 65

                          90       100
                  ....*....|....*....|....*..
gi 1720367788 116 HnvamMLAQLINDGSPMVRKELVVALS 142
Cdd:pfam13646  66 A----LLELLRDDDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
72-144 5.88e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 5.88e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720367788  72 DSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDHnvammLAQLINDGSPMVRKELVVALSHL 144
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALG--------RLGDPRAVPA-----LLEALKDPDPEVRAAAAEALGRI 74
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 78-101 1.87e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 36.35  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....
gi 1720367788  78 LYSLLSDPIPEVRCAAVFALGTFV 101
Cdd:pfam02985   5 LLKLLNDPSPEVREAAAEALGELA 28
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 32-62 6.04e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.81  E-value: 6.04e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720367788  32 LIAICLEQLSDPHPLLRQWVAICLGRIWQNF 62
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH