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Conserved domains on  [gi|1720432849|ref|XP_030100494|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-256 1.90e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.73  E-value: 1.90e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   19 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 98
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 178
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849  179 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKG 256
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 470-1293 1.70e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 1.70e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  470 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 542
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  543 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 622
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  623 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 698
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  699 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 778
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  779 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 839
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  840 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 899
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  900 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 964
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  965 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1044
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1045 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1124
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1125 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1204
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1205 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1273
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1720432849 1274 DKSLTTIMELQQRIQESAKQ 1293
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 278-603 6.83e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  278 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 357
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  358 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 437
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  438 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 514
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  515 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 594
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1720432849  595 RGRRVVELE 603
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-256 1.90e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.73  E-value: 1.90e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   19 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 98
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 178
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849  179 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKG 256
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 470-1293 1.70e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 1.70e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  470 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 542
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  543 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 622
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  623 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 698
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  699 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 778
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  779 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 839
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  840 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 899
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  900 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 964
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  965 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1044
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1045 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1124
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1125 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1204
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1205 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1273
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1720432849 1274 DKSLTTIMELQQRIQESAKQ 1293
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 3.97e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.24  E-value: 3.97e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   92 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1720432849  172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-203 9.42e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   35 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  111 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170
                   ....*....|....*
gi 1720432849  189 TALMLGCEYGCRDAV 203
Cdd:PHA03095   292 TPLSLMVRNNNGRAV 306
PTZ00121 PTZ00121
MAEBL; Provisional
 443-1266 2.71e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  443 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 520
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  521 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 598
Cdd:PTZ00121  1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  599 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 678
Cdd:PTZ00121  1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  679 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 758
Cdd:PTZ00121  1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  759 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 836
Cdd:PTZ00121  1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  837 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 914
Cdd:PTZ00121  1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  915 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 994
Cdd:PTZ00121  1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  995 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1074
Cdd:PTZ00121  1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1075 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1148
Cdd:PTZ00121  1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1149 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1209
Cdd:PTZ00121  1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1210 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1266
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 472-1299 1.34e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.93  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  472 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 540
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  541 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 618
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  619 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 696
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  697 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 768
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  769 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 848
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  849 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 928
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  929 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1005
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1006 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1071
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1072 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1151
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1152 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1227
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1228 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1299
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1051-1394 2.13e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.89  E-value: 2.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1130
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1131 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1207
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1208 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1287
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1288 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1367
Cdd:COG1196    466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                          330       340
                   ....*....|....*....|....*..
gi 1720432849 1368 LLSAAQGHMDEDVQAALLQIIQMRQGL 1394
Cdd:COG1196    540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 15-221 4.32e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 54.70  E-value: 4.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   15 SAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGIDVATrdsaG 88
Cdd:TIGR00870   11 ESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCRGAV----G 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   89 RNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASVNAK----- 150
Cdd:TIGR00870   83 DTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASVPARacgdf 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  151 -----DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY----------------G 198
Cdd:TIGR00870  163 fvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmynfalslldK 242

                          250       260
                   ....*....|....*....|....
gi 1720432849  199 CRDAVEV-LVKNGADLTLLDALGH 221
Cdd:TIGR00870  243 LRDSKELeVILNHQGLTPLKLAAK 266
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-191 4.75e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   63 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 134
Cdd:cd22192     25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849  135 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:cd22192    103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 278-603 6.83e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  278 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 357
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  358 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 437
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  438 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 514
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  515 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 594
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1720432849  595 RGRRVVELE 603
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-256 1.90e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.73  E-value: 1.90e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   19 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 98
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 178
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849  179 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGRELWRKG 256
Cdd:COG0666    211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-248 7.75e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 7.75e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   16 AEWNKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 95
Cdd:COG0666     15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   96 AKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLID 175
Cdd:COG0666     95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720432849  176 RGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNK 248
Cdd:COG0666    175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-239 1.05e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 1.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   40 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDL 119
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  120 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 199
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1720432849  200 RDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 239
Cdd:COG0666    166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 470-1293 1.70e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 1.70e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  470 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 542
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  543 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 622
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  623 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 698
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  699 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 778
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  779 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 839
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  840 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 899
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  900 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 964
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  965 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1044
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1045 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1124
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1125 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1204
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1205 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1273
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 1720432849 1274 DKSLTTIMELQQRIQESAKQ 1293
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-191 1.84e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.26  E-value: 1.84e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   25 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 104
Cdd:COG0666    124 LHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  105 QKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRD 184
Cdd:COG0666    203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                   ....*..
gi 1720432849  185 KQNRTAL 191
Cdd:COG0666    283 LDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-239 3.42e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 3.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   71 LNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 150
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  151 DIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIG 230
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                   ....*....
gi 1720432849  231 DNLDILNLL 239
Cdd:COG0666    164 GNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 3.97e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.24  E-value: 3.97e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   92 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1720432849  172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-203 9.42e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   35 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095   132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  111 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                          170
                   ....*....|....*
gi 1720432849  189 TALMLGCEYGCRDAV 203
Cdd:PHA03095   292 TPLSLMVRNNNGRAV 306
Ank_2 pfam12796
Ankyrin repeats (3 copies);
59-151 2.68e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.93  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   59 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTehVDLQGRTALHDAAMADCPSSIQ 138
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN--LKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1720432849  139 LLCDHGASVNAKD 151
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 443-1266 2.71e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  443 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 520
Cdd:PTZ00121  1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  521 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 598
Cdd:PTZ00121  1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  599 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 678
Cdd:PTZ00121  1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  679 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 758
Cdd:PTZ00121  1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  759 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 836
Cdd:PTZ00121  1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  837 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 914
Cdd:PTZ00121  1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  915 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 994
Cdd:PTZ00121  1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  995 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1074
Cdd:PTZ00121  1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1075 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1148
Cdd:PTZ00121  1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1149 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1209
Cdd:PTZ00121  1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1210 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1266
Cdd:PTZ00121  1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
620-1206 6.38e-18

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 90.12  E-value: 6.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  620 EKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKN 699
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKI 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  700 QTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKshdvnVEDLNKKLSEATQRYTEKKQEAERLLAendKL 779
Cdd:PRK03918   262 RELEERIEELKKEIEELEEKVKEL--------------KELKE-----KAEEYIKLSEFYEEYLDELREIEKRLS---RL 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  780 TKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkasl 859
Cdd:PRK03918   320 EEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEL-EERHELYEEAKAKKEELERLKKRLT---------------- 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  860 NSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevlRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN-----A 934
Cdd:PRK03918   383 GLTPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKElleeyT 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  935 AILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklKYAPLARLEECERKFKATEKGLKEQLSEqthKCRQRDEEVKKGK 1014
Cdd:PRK03918   459 AELKRIEKELKEIEEKERKLRKELRELEKVLK----KESELIKLKELAEQLKELEEKLKKYNLE---ELEKKAEEYEKLK 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1015 QENERLRADLAALQKELQDRNALAEEAREAERalsgKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLL 1094
Cdd:PRK03918   532 EKLIKLKGEIKSLKKELEKLEELKKKLAELEK----KLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLEL 607

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1095 QKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQqllenQKNSSVTLAEHLKLKEALEKEVGIMKASL 1174
Cdd:PRK03918   608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELE-----KKYSEEEYEELREEYLELSRELAGLRAEL 682

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1720432849 1175 REKEEESQKKTKEVSKLQTEVQTTKQALKNLE 1206
Cdd:PRK03918   683 EELEKRREEIKKTLEKLKEELEEREKAKKELE 714
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 528-1350 6.06e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 87.05  E-value: 6.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  528 IIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEfkRDEGRLVEENKRLQKECGTCEVELERRGRRVVE 601
Cdd:TIGR02169  192 IIDEKRQQLERLRRerekaeRYQALLKEKREYEGYELLKEKEALE--RQKEAIERQLASLEEELEKLTEEISELEKRLEE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  602 LEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEheqLRSRL 681
Cdd:TIGR02169  270 IEQLLEELNKKI------------KDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEA---EIDKL 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  682 EQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRvseemkkshdvnveDLNKKLSEATQR 761
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELK--------------DYREKLEKLKRE 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  762 YTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELnkkcgegQEKIRALMSENSSLKKT 841
Cdd:TIGR02169  401 INELKRELDRLQEELQRLSEELADLNA----------AIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  842 LSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMkADYVSLEEH------ 915
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERyataie 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  916 ---SRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHaEIKAQKKELDTIQECIKLKYAplARLEECERKFKATEK-- 990
Cdd:TIGR02169  543 vaaGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKYEPAFKyv 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  991 -----------------------GLKEQLSEQT-------HKCRQRDEEVKKGKQENERLRADLAALQKELQDrnalaee 1040
Cdd:TIGR02169  620 fgdtlvvedieaarrlmgkyrmvTLEGELFEKSgamtggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSS------- 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1041 AREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE 1120
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1121 ElrskqrcLEREQQTVSQLQQLLENQKNSSVTlaehlKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1200
Cdd:TIGR02169  773 D-------LHKLEEALNDLEARLSHSRIPEIQ-----AELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1201 ALKNLETRevvdmskykatKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIRDQKERcdksltti 1280
Cdd:TIGR02169  841 QRIDLKEQ-----------IKSIEKEIENLNGKKEELEEELEEL--EAALRDLESRLGDLKKERDELEAQLR-------- 899

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1281 mELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTySSGSPTKRQSQLVDTLQQRVRDLQQQL 1350
Cdd:TIGR02169  900 -ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK-GEDEEIPEEELSLEDVQAELQRVEEEI 967
PTZ00121 PTZ00121
MAEBL; Provisional
 616-1313 1.01e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 86.73  E-value: 1.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  616 SVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQ-----LKRDLESVRAQHIRPEEH----EQLRSRLEQKSG 686
Cdd:PTZ00121  1075 SYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARkaeeaKKKAEDARKAEEARKAEDarkaEEARKAEDAKRV 1154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  687 ELGKKVSELTLKNQTLQ-KDVEKLHADNKL--------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 757
Cdd:PTZ00121  1155 EIARKAEDARKAEEARKaEDAKKAEAARKAeevrkaeeLRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  758 ATQRYTE-KKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKkcgeGQEKIRAlmsenS 836
Cdd:PTZ00121  1235 AKKDAEEaKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKK----AEEKKKA-----D 1305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  837 SLKKtlssqyvpaKTHEEVKA-SLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 915
Cdd:PTZ00121  1306 EAKK---------KAEEAKKAdEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  916 SRRMSTVSQSLKEAQEANaailadhrqgqeeivslhaeiKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 995
Cdd:PTZ00121  1377 KKKADAAKKKAEEKKKAD---------------------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADE 1435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  996 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1075
Cdd:PTZ00121  1436 AKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEA 1515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1076 LVEEKAKQASEILAAQNllQKQPVPLEQVEALKKSlngtieqlkEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1155
Cdd:PTZ00121  1516 KKAEEAKKADEAKKAEE--AKKADEAKKAEEKKKA---------DELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAE 1584

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1156 HLKLKE--------ALEKEVGIMKASLREKEEESQKKTKEVSKlQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQI 1227
Cdd:PTZ00121  1585 EAKKAEearieevmKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1228 SNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEqeirdQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLND 1307
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE-----EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE 1738


                   ....*.
gi 1720432849 1308 VERLKQ 1313
Cdd:PTZ00121  1739 AEEDKK 1744
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-217 1.33e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  125 LHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1720432849  205 VLVKNGADLTLLD 217
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 634-1351 1.34e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 1.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  634 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH----------------------IRPEEHEQLRSRLEQKSGELGKK 691
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDILNELERQLKSLERQAekaerykelkaelrelelallvLRLEELREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  692 VSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAER 771
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  772 LLAENDKLTKNVSRLEAVFVAP----EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS--- 844
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLeaelEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERled 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  845 ---------QYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL---ENVQNQMKADYVSL 912
Cdd:TIGR02168  415 rrerlqqeiEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALdaaERELAQLQARLDSL 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  913 EEHSRRMSTVSQSLKE--------------------------------------------AQEANAAI--LADHRQGQ-- 944
Cdd:TIGR02168  495 ERLQENLEGFSEGVKAllknqsglsgilgvlselisvdegyeaaieaalggrlqavvvenLNAAKKAIafLKQNELGRvt 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  945 --EEIVSLHAEIKAQKKELDTIQECIKlkyAPLARLEECERKFKATEKGL------KEQLSEQTHKCRQRDEEVKKGKQE 1016
Cdd:TIGR02168  575 flPLDSIKGTEIQGNDREILKNIEGFL---GVAKDLVKFDPKLRKALSYLlggvlvVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1017 NERLRADLAALQKE------LQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1090
Cdd:TIGR02168  652 GDLVRPGGVITGGSaktnssILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1091 QNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQ-------QTVSQLQQLLENQKNSSVTLAEHLKlkeAL 1163
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEeelaeaeAEIEELEAQIEQLKEELKALREALD---EL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1164 EKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtrevVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ 1243
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELIEELESELEALLNERAS 884

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1244 ACEEKVSAKDEKELLhlsiEQEIRDQKERcdkslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTY 1323
Cdd:TIGR02168  885 LEEALALLRSELEEL----SEELRELESK-------RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL 953

                          810       820
                   ....*....|....*....|....*....
gi 1720432849 1324 SSGSPTKRQSQL-VDTLQQRVRDLQQQLA 1351
Cdd:TIGR02168  954 EEAEALENKIEDdEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 756-1359 1.68e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 1.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  756 SEATQRYTEKKQEAERLLAE--NDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 833
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAllVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  834 ENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLE 913
Cdd:TIGR02168  289 ELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  914 EHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK--LKYAPLARLEECERKFKATEKG 991
Cdd:TIGR02168  369 ELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELEELEEE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  992 LKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKS 1071
Cdd:TIGR02168  449 LEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1072 EREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNG------------------TIEQLKEELRSKQRC 1128
Cdd:TIGR02168  525 LSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQNELGrvtflpldsikgteiqgnDREILKNIEGFLGVA 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 LEREQQT----------------VSQLQQLLENQKNSS-----VTLAEHL------KLKEALEKEVGIM--KASLREKEE 1179
Cdd:TIGR02168  605 KDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyriVTLDGDLvrpggvITGGSAKTNSSILerRREIEELEE 684

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1180 ESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDKLASLNRK-------YDQACEEKVSAK 1252
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEE----ELEQLRKELEELSRQISALRKDLARLEAEveqleerIAQLSKELTELE 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1253 DEKELLHLSIEQEIRDQKERCDKslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQ 1332
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAE----IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836

                          650       660
                   ....*....|....*....|....*..
gi 1720432849 1333 SQLVDTLQQRVRDLQQQLADADRQHQE 1359
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEIEE 863
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 470-1283 5.77e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.96  E-value: 5.77e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  470 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH------FLALKEHLTNEAATGSHRIIEELREQLKDLKGKY 543
Cdd:TIGR02169  167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRErekaerYQALLKEKREYEGYELLKEKEALERQKEAIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  544 EGASAEVGKLRSQIKQSEMLVGEF--------KRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLA- 614
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIeqlleelnKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAk 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  615 LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRP-EEHEQLRSRLEQksgeLGKKVS 693
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETrDELKDYREKLEK----LKREIN 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  694 ELTLKNQTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQrytekkqEAERLL 773
Cdd:TIGR02169  403 ELKRELDRLQEELQRLSEELADLNAAIAGI--------------EAKINELEEEKEDKALEIKKQEW-------KLEQLA 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  774 AENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS------QYV 847
Cdd:TIGR02169  462 ADLSKYEQELYDLKEEY---DRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQlgsvgeRYA 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  848 PAKtheEVKAS--LNSTVEKTNR------ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRrm 919
Cdd:TIGR02169  539 TAI---EVAAGnrLNNVVVEDDAvakeaiELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYE-- 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  920 STVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQ 999
Cdd:TIGR02169  614 PAFKYVFGDTLVVEDIEAARRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSL 693

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1000 THKCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEE 1079
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEIEKEIE-------QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEAR 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1080 KAKQASEILAAQNLLQK-----QPVPLEQVEALKKSLNGTIEQLKEELRSkqrcLEREQQTVSQLQQLLENQKNSSVTLA 1154
Cdd:TIGR02169  767 IEELEEDLHKLEEALNDlearlSHSRIPEIQAELSKLEEEVSRIEARLRE----IEQKLNRLTLEKEYLEKEIQELQEQR 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1155 EHLKL-KEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDK 1233
Cdd:TIGR02169  843 IDLKEqIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA----QLRELERKIEELEAQIEKKRKR 918

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720432849 1234 LASLNRKYdQACEEKVSAKDEKELLHLSIEQE---IRDQKERCDKSLTTIMEL 1283
Cdd:TIGR02169  919 LSELKAKL-EALEEELSEIEDPKGEDEEIPEEelsLEDVQAELQRVEEEIRAL 970
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 718-1394 1.46e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.41  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  718 QQVHSLTVEMKTRYVPL-RVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLlaeNDKLTKNVSRLEAvfvapekH 796
Cdd:TIGR02168  189 DRLEDILNELERQLKSLeRQAEKAERYKELKAELRELELALLVLRLEELREELEEL---QEELKEAEEELEE-------L 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  797 EKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKR 876
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQK-------QILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  877 FDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKA 956
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLER 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  957 QKKELDTIQECIK--LKYAPLARLEECERKFKATEKGLKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDR 1034
Cdd:TIGR02168  412 LEDRRERLQQEIEelLKKLEEAELKELQAELEELEEELEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQL 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1035 NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKK 1109
Cdd:TIGR02168  488 QARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQ 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1110 SLNG------------------TIEQLKEELRSKQRCLEREQQT----------------VSQLQQLLENQKNSS----- 1150
Cdd:TIGR02168  568 NELGrvtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyri 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1151 VTLAEHL-----------------------KLKEaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLET 1207
Cdd:TIGR02168  648 VTLDGDLvrpggvitggsaktnssilerrrEIEE-LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1208 REVVDMSKYKATKN----------DLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLhlsiEQEIRDQKERCDKSL 1277
Cdd:TIGR02168  727 QISALRKDLARLEAeveqleeriaQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL----EAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1278 TTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQH 1357
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ-------IEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1720432849 1358 QEVIAIYRT-----HLLSAAQGHMDEDVQAALLQIIQMRQGL 1394
Cdd:TIGR02168  876 EALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
747-1313 2.31e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 81.65  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  747 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 826
Cdd:PRK03918   180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  827 KIRALMSENSSLKKTLssqyvpaKTHEEVKASLNStVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 906
Cdd:PRK03918   260 KIRELEERIEELKKEI-------EELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  907 adyvSLEEHSRRMSTVSQSLKEAQEANAAIladhrqgqEEIVSLHAEIKAQKKELDTIQECIKLKyaplaRLEECERKFK 986
Cdd:PRK03918   332 ----ELEEKEERLEELKKKLKELEKRLEEL--------EERHELYEEAKAKKEELERLKKRLTGL-----TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  987 ATEKGlKEQLSEQTHKCRQRDEEVkkgKQENERLRADLAALQKE-----LQDRNALAEEAREAERALSGKADELSKQLKD 1061
Cdd:PRK03918   395 ELEKA-KEEIEEEISKITARIGEL---KKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELLEEYTAELKRIEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1062 LSQKYSDVKSEREKlVEEKAKQASEILAAQNLlqkqpvpLEQVEALKKSLNG-TIEQLK------EELRSKQRCLEREQQ 1134
Cdd:PRK03918   471 IEEKERKLRKELRE-LEKVLKKESELIKLKEL-------AEQLKELEEKLKKyNLEELEkkaeeyEKLKEKLIKLKGEIK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1135 TVSQLQQLLENQKNSSVTLAEHLK-LKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdm 1213
Cdd:PRK03918   543 SLKKELEKLEELKKKLAELEKKLDeLEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREE---- 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1214 SKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDE----KELLHLSIEQEI---RDQKERCDKSLTTIMELQQR 1286
Cdd:PRK03918   619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEeyeeLREEYLELSRELaglRAELEELEKRREEIKKTLEK 698

                          570       580       590
                   ....*....|....*....|....*....|
gi 1720432849 1287 IQESAKQIEAKDNKITEL---LNDVERLKQ 1313
Cdd:PRK03918   699 LKEELEEREKAKKELEKLekaLERVEELRE 728
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 332-1237 1.09e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 79.72  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  332 ESEREKLKSLLAAKEKQHEESLRTIEALKNRfkyfesdhpgpgsypSNRKEDMLHKQGQMYTTEpqcaspgipphmHSRS 411
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEELKE---------------AEEELEELTAELQELEEK------------LEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  412 MLRPLELSlpsqtsyseneilkKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 491
Cdd:TIGR02168  273 RLEVSELE--------------EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  492 VQkrmyESEGKVKQMQTHFLALKEHLTNEAAT--GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR 569
Cdd:TIGR02168  339 LA----ELEEKLEELKEELESLEAELEELEAEleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLED 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  570 DEGRLVEENKRLQKEcgTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYES 649
Cdd:TIGR02168  415 RRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEEL------ERLEEALEELREELEEAEQALDAAERELAQ 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  650 AQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVS-----ELTLKNqTLQKDVEKLHADNK-LLNQQVHSL 723
Cdd:TIGR02168  487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyEAAIEA-ALGGRLQAVVVENLnAAKKAIAFL 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  724 TVEMKTRYVPLRVSeemkkshDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS-RLEAVFVAPEkhekelmg 802
Cdd:TIGR02168  566 KQNELGRVTFLPLD-------SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyLLGGVLVVDD-------- 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  803 LKSNIAELKKQLSELNKKCGEGQekiralmsensslkkTLSSQYVPAKTHEEVKASLNStvekTNRALLEAKKRFDDTSQ 882
Cdd:TIGR02168  631 LDNALELAKKLRPGYRIVTLDGD---------------LVRPGGVITGGSAKTNSSILE----RRREIEELEEKIEELEE 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  883 EVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELD 962
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLE 771

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  963 TIQEciklkyaplaRLEECERKfkatekglKEQLSEQThkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAR 1042
Cdd:TIGR02168  772 EAEE----------ELAEAEAE--------IEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLE 830

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1043 EAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEEL 1122
Cdd:TIGR02168  831 RRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1123 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEkevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQAL 1202
Cdd:TIGR02168  911 SELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLT---------LEEAEALENKIEDDEEEARRRLKRLENKI 981

                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 1720432849 1203 KNLETREVVDMSKYKATK---NDLETQISNLNDKLASL 1237
Cdd:TIGR02168  982 KELGPVNLAAIEEYEELKeryDFLTAQKEDLTEAKETL 1019
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 62-214 2.33e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 78.37  E-value: 2.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   62 VASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLC 141
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720432849  142 dHGASVNAKDIDGRTpLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLT 214
Cdd:PLN03192   612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-181 3.47e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 76.63  E-value: 3.47e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   33 DVEKVSSILAKKGVHPGKLDVEGRSAFHVVASK--GNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHA------LCL 104
Cdd:PHA03100    84 DVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  105 QK------------LLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 172
Cdd:PHA03100   164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                   ....*....
gi 1720432849  173 LIDRGADVN 181
Cdd:PHA03100   244 LLNNGPSIK 252
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 681-1309 7.01e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.60  E-value: 7.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  681 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKtryvplrvseEMKKSHDVNVEDLNKKLSEatq 760
Cdd:TIGR04523   80 LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELN----------KLEKQKKENKKNIDKFLTE--- 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  761 rYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIralmsensSLKK 840
Cdd:TIGR04523  147 -IKKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKI--------QKNK 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  841 TLSSQYVPAKtheEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkadyvsLEEHSRRMS 920
Cdd:TIGR04523  215 SLESQISELK---KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKE-------LEQNNKKIK 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  921 TVSqslKEAQEANAAILADHRQGQEEIVS-LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGL------- 992
Cdd:TIGR04523  285 ELE---KQLNQLKSEISDLNNQKEQDWNKeLKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSesensek 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  993 KEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSE 1072
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1073 REKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclereqqtVSQLQQLLENQKNSSVT 1152
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSK----------EKELKKLNEEKKELEEK 511

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1153 LAEhlklkeaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-----MSKYKATKNDLEtqi 1227
Cdd:TIGR04523  512 VKD-------LTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDeknkeIEELKQTQKSLK--- 581

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1228 sNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQ---QRIQESAKQIEAKDNKITEL 1304
Cdd:TIGR04523  582 -KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKskkNKLKQEVKQIKETIKEIRNK 660


                   ....*
gi 1720432849 1305 LNDVE 1309
Cdd:TIGR04523  661 WPEII 665
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 472-1299 1.34e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.93  E-value: 1.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  472 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 540
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  541 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 618
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  619 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 696
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  697 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 768
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  769 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 848
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  849 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 928
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  929 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1005
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1006 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1071
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1072 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1151
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1152 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1227
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1228 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1299
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
432-1022 1.67e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.49  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  432 LKKELETLRTYYDSAKQdRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ---- 507
Cdd:PRK03918   212 ISSELPELREELEKLEK-EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelke 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  508 --THFLALKEhLTNEAATGSHRI----------IEELREQLKDLKGKyegaSAEVGKLRSQIKQSEMLVGEFKRDEgRLV 575
Cdd:PRK03918   291 kaEEYIKLSE-FYEEYLDELREIekrlsrleeeINGIEERIKELEEK----EERLEELKKKLKELEKRLEELEERH-ELY 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  576 EENKRLQKECGtcEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVgrdyESAQGEI 654
Cdd:PRK03918   365 EEAKAKKEELE--RLKKRLTGLTPEKLEKELEELeKAKEEIEEEISKITARIGELKKEIKELKKAIEEL----KKAKGKC 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  655 RQLKRDLESvraqhirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhaDNKLLNQqvhSLTVEMKTRYVPL 734
Cdd:PRK03918   439 PVCGRELTE--------EHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL--EKVLKKE---SELIKLKELAEQL 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  735 RVSEEMKKSHDVnvedlnKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQL 814
Cdd:PRK03918   506 KELEEKLKKYNL------EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEEL-------KKKLAELEKKLDELEEEL 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  815 SELNKKCGE-GQEKIRALMSENSSLKKtLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEV 893
Cdd:PRK03918   573 AELLKELEElGFESVEELEERLKELEP-FYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  894 LRRNLEnvqnqmKADYVSLEEHSRRMSTVSQSLKEAQEAnaaiLADHRqgqEEIVSLHAEIKAQKKELDTIQECIKLKYA 973
Cdd:PRK03918   652 LEKKYS------EEEYEELREEYLELSRELAGLRAELEE----LEKRR---EEIKKTLEKLKEELEEREKAKKELEKLEK 718

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720432849  974 PLARLEECERKFKATEKGLKEQ-LSEQTHKCRQRDEEVKKGKQENERLRA 1022
Cdd:PRK03918   719 ALERVEELREKVKKYKALLKERaLSKVGEIASEIFEELTEGKYSGVRVKA 768
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 74-213 2.36e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.71  E-value: 2.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   74 ILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCP-SSIQLLCDHGASVNAKDI 152
Cdd:PHA02876   361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNK 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720432849  153 DGRTPLVLATQM-CRPTICQLLIDRGADVNSRDKQNRTALMLGCEYgcRDAVEVLVKNGADL 213
Cdd:PHA02876   441 DLSTPLHYACKKnCKLDVIEMLLDNGADVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 761-1359 2.41e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 2.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  761 RYTEKKQEAERLLAENDKltkNVSRLEAVfvapekhekelmglksnIAELKKQLSELNKKcGEGQEKIRALMSENSSLKK 840
Cdd:TIGR02168  169 KYKERRKETERKLERTRE---NLDRLEDI-----------------LNELERQLKSLERQ-AEKAERYKELKAELRELEL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  841 TLSS-QYVPAKTH----EEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 915
Cdd:TIGR02168  228 ALLVlRLEELREEleelQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  916 SRRMSTVSQSLKEAQEanaaILADHRQGQEEivsLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 995
Cdd:TIGR02168  308 RERLANLERQLEELEA----QLEELESKLDE---LAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  996 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1075
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELER 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1076 LVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS-KQRCLEREQ--QTVSQLQQLLENQKN---- 1148
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGvKALLKNQSGlsGILGVLSELISVDEGyeaa 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1149 SSVTLAEHL-----KLKEALEKEVGIMKASLREKE---EESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1220
Cdd:TIGR02168  539 IEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVtflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAL 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1221 NDL------ETQISNLNDKLASLNRKY-------DQACEEKVSAK--DEKELLHLSIEQEIRDQKERCDkslttimELQQ 1285
Cdd:TIGR02168  619 SYLlggvlvVDDLDNALELAKKLRPGYrivtldgDLVRPGGVITGgsAKTNSSILERRREIEELEEKIE-------ELEE 691

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720432849 1286 RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1359
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 479-1282 5.17e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.90  E-value: 5.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  479 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSHRIIEELREQLKDLKGKyegasaevgklrsqIK 558
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN-----SNNKIKILEQQIKDLNDK--------------LK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  559 QSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQLKELGAKLAL-SVPTEKFESMKSSLSNDINEKV 637
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNK-------LEKQKKENKKNIDKfLTEIKKKEKELEKLNNKYNDLK 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  638 KRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLN 717
Cdd:TIGR04523  166 KQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKT 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  718 QQVHSLTVEMKTryvplrvseeMKKSHDVNVEDLNKKLSEATQryTEKKqeaerllaeNDKLTKNVSRLEAVFVA--PEK 795
Cdd:TIGR04523  246 TEISNTQTQLNQ----------LKDEQNKIKKQLSEKQKELEQ--NNKK---------IKELEKQLNQLKSEISDlnNQK 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  796 HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkaSLNSTVEKTNRALLEAKk 875
Cdd:TIGR04523  305 EQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT--------------NSESENSEKQRELEEKQ- 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  876 rfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaailaDHRQGQEEIVSLHAEIK 955
Cdd:TIGR04523  370 ------NEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ-------EKELLEKEIERLKETII 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  956 AQKKELDTIQECIklkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1035
Cdd:TIGR04523  437 KNNSEIKDLTNQD-------SVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK--- 506

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1036 alaeeareaeralsgkadELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL--EQVEALKKSLNG 1113
Cdd:TIGR04523  507 ------------------ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEKNK 568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1114 TIEQLKEElrskQRCLEREQQTVSQL-QQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1192
Cdd:TIGR04523  569 EIEELKQT----QKSLKKKQEEKQELiDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLK 644

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1193 TEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELL--HLSIEQEIRDQK 1270
Cdd:TIGR04523  645 QEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLPKLEekYKEIEKELKKLD 724

                          810
                   ....*....|..
gi 1720432849 1271 ErCDKSLTTIME 1282
Cdd:TIGR04523  725 E-FSKELENIIK 735
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 285-1031 5.30e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.32  E-value: 5.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  285 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEevmvaddLESEREKLKSLLAAKEKQHEESLRTIEALKNRFK 364
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEE-------LRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  365 YFesdhpgpgsypsNRKEDMLHKQGQMYTTEpqcaspgipphmhsrsmlrplelslpSQTSYSENEILKKELETLRTYYD 444
Cdd:TIGR02168  306 IL------------RERLANLERQLEELEAQ--------------------------LEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  445 SAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATG 524
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEI 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  525 S--------------HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQkecgTCEV 590
Cdd:TIGR02168  424 EellkkleeaelkelQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE----RLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  591 ELERRGRRVVELEGQLKELGAKLA-----LSVPtEKFE-SMKSSLSNDINekvkrlAEVGRDYESAQGEIRQLKRD---- 660
Cdd:TIGR02168  500 NLEGFSEGVKALLKNQSGLSGILGvlselISVD-EGYEaAIEAALGGRLQ------AVVVENLNAAKKAIAFLKQNelgr 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  661 -----LESVRAQHIRPEEHEQLRS---------RLEQKSGELGKKVSELtLKNQTLQKDVEKLHADNKLLNQQVHSLTVE 726
Cdd:TIGR02168  573 vtflpLDSIKGTEIQGNDREILKNiegflgvakDLVKFDPKLRKALSYL-LGGVLVVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  727 ---MKTRYVPLRVSEEMKKS---HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvAPEKHEKEL 800
Cdd:TIGR02168  652 gdlVRPGGVITGGSAKTNSSileRRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK---ELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  801 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDT 880
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  881 SQEVSKLRDENEVLRRNLENVQNQMkadyvslEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKE 960
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRI-------AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNE 881

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849  961 LDTIQEciklkyaPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1031
Cdd:TIGR02168  882 RASLEE-------ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-248 5.44e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 5.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   25 LMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 104
Cdd:PHA02874   128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  105 QKLLQYncpTEHVDLQ---GRTALHDAAMADcPSSIQLLCDHgASVNAKDIDGRTPLVLATQM-CRPTICQLLIDRGADV 180
Cdd:PHA02874   207 KLLIDH---GNHIMNKcknGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPpCDIDIIDILLYHKADI 281

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720432849  181 NSRDKQNRTALMLGCEYGCRDAV-------EVLVKNGADLTLLDALGHDSsyyarIGDNLDILNLLKTASENTNK 248
Cdd:PHA02874   282 SIKDNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
PHA03095 PHA03095
ankyrin-like protein; Provisional
 29-239 5.79e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 5.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   29 AERGDVEKVSSILAKKGvhpgklDVE-----GRSAFHVVASKGN---LECLNAILTHGIDVATRDSAGRNALHLAAKYGH 100
Cdd:PHA03095    22 ASNVTVEEVRRLLAAGA------DVNfrgeyGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  101 ALCLQKLL-QYNCPTEHVDLQGRTALHDAAMADC--PSSIQLLCDHGASVNAKDIDGRTPL--VLATQMCRPTICQLLID 175
Cdd:PHA03095    96 TLDVIKLLiKAGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLID 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  176 RGADVNSRDKQNRTALMLGCEYgCRD---AVEVLVKNGADLTLLDALGHDSSYYARIGD---NLDILNLL 239
Cdd:PHA03095   176 AGADVYAVDDRFRSLLHHHLQS-FKPrarIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLL 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 423-1198 1.05e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 73.23  E-value: 1.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  423 QTSYSENEILKKELETLRTYYDSAKQDrlkFQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGK 502
Cdd:pfam15921  116 QTKLQEMQMERDAMADIRRRESQSQED---LRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGV 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  503 VKQMQTHFLALKE---------------HLTNeAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGE 566
Cdd:pfam15921  186 LQEIRSILVDFEEasgkkiyehdsmstmHFRS-LGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKiELLLQQ 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  567 FKRDEGRLVEENKrlqkecgtcevelerrgrrvVELEGQlkelgaklalsvpTEKFESMKSSlSNDINEKVKRLAEVGRD 646
Cdd:pfam15921  265 HQDRIEQLISEHE--------------------VEITGL-------------TEKASSARSQ-ANSIQSQLEIIQEQARN 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  647 YESAQgeIRQLKrDLESVRAQhIRPEEHEQLRSrLEQKSGELGKkvsELTLKNQTL---QKDVEKLHADNKLLNQQVHSL 723
Cdd:pfam15921  311 QNSMY--MRQLS-DLESTVSQ-LRSELREAKRM-YEDKIEELEK---QLVLANSELteaRTERDQFSQESGNLDDQLQKL 382

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  724 TVEMKTRYVPLRVSEEMkkshdvnvedlNKKLSEatqRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPE-----KHEK 798
Cdd:pfam15921  383 LADLHKREKELSLEKEQ-----------NKRLWD---RDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKsecqgQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  799 ELMGLKSNIAELKKqLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpAKTHEEVKASLNS---TVEKTNRALLEAKK 875
Cdd:pfam15921  449 QMAAIQGKNESLEK-VSSLTAQLESTKEMLRKVVEELTAKKMTLESS---ERTVSDLTASLQEkerAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  876 RFDDTSQEVSKLRDENEVLRrnleNVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIK 955
Cdd:pfam15921  525 RVDLKLQELQHLKNEGDHLR----NVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN 600

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  956 AQKKELdtiQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQrdeeVKKGKQENERLRADLAALQKELQDRN 1035
Cdd:pfam15921  601 DRRLEL---QEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA----VKDIKQERDQLLNEVKTSRNELNSLS 673

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1036 ALAEEAREAERALSGKADELSKQLK-DLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNgT 1114
Cdd:pfam15921  674 EDYEVLKRNFRNKSEEMETTTNKLKmQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQ-F 752

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1115 IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-----SVTLAEHLKLKEALEK-EVGIMKASLREKEEESQKKTKEV 1188
Cdd:pfam15921  753 LEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKmagelEVLRSQERRLKEKVANmEVALDKASLQFAECQDIIQRQEQ 832

                          810
                   ....*....|
gi 1720432849 1189 SKLQTEVQTT 1198
Cdd:pfam15921  833 ESVRLKLQHT 842
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-112 1.41e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 1.41e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   25 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIdvATRDSAGRNALHLAAKYGHALCL 104
Cdd:pfam12796    1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                   ....*...
gi 1720432849  105 QKLLQYNC 112
Cdd:pfam12796   78 KLLLEKGA 85
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
481-1156 1.93e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.02  E-value: 1.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  481 QIKQLEDALKDVQKRMYESEGKVKQMQThFLALKEHLTNEAATGSHRIIEELREqLKDLKGKYEGASAEVGKLRSQIKQS 560
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEK-FIKRTENIEELIKEKEKELEEVLRE-INEISSELPELREELEKLEKEVKEL 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  561 EMLVGEFKRdegrLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELgaklalsvpTEKFESMKSslsndINEKVKRL 640
Cdd:PRK03918   234 EELKEEIEE----LEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL---------EEKVKELKE-----LKEKAEEY 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  641 AEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSEltlknqtLQKDVEKLHADNKLLnQQV 720
Cdd:PRK03918   296 IKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE-------LEKRLEELEERHELY-EEA 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  721 HSLTVEMKtryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAendkltknvsrleavfvapekhekEL 800
Cdd:PRK03918   368 KAKKEELE---------RLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITA------------------------RI 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  801 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENsslKKTLSSQYvpaktHEEVKaSLNSTVEKTNRALLEAKKRFddt 880
Cdd:PRK03918   415 GELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH---RKELLEEY-----TAELK-RIEKELKEIEEKERKLRKEL--- 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  881 sQEVSKLRDENEVLRRNLEnVQNQMKADYVSLEEHsrrmstvsqSLKEAQEANaailADHRQGQEEIVSLHAEIKAQKKE 960
Cdd:PRK03918   483 -RELEKVLKKESELIKLKE-LAEQLKELEEKLKKY---------NLEELEKKA----EEYEKLKEKLIKLKGEIKSLKKE 547

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  961 LDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLR---ADLAALQKELQDRNAL 1037
Cdd:PRK03918   548 LEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEE 627

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1038 AEEAREAERALSGKADELSKQLKDLSQKYSDvkSEREKLVEEKAKQASEILAAQNllqkqpvPLEQVEALKKSLNGTIEQ 1117
Cdd:PRK03918   628 LDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRA-------ELEELEKRREEIKKTLEK 698

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 1720432849 1118 LKEEL---RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH 1156
Cdd:PRK03918   699 LKEELeerEKAKKELEKLEKALERVEELREKVKKYKALLKER 740
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1051-1394 2.13e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.89  E-value: 2.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1130
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1131 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1207
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1208 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1287
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1288 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1367
Cdd:COG1196    466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                          330       340
                   ....*....|....*....|....*..
gi 1720432849 1368 LLSAAQGHMDEDVQAALLQIIQMRQGL 1394
Cdd:COG1196    540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-232 5.75e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 5.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   32 GDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGN-LECLNAILTHGIDVATRDSAGRNALH--LAAKYGHALCLQKLL 108
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  109 QYNCPTEHVDLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRP--TICQLLIDRGADV 180
Cdd:PHA03095   140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDP 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720432849  181 NSRDKQNRTALMLGCEYG-CRDA-VEVLVKNGADLTLLDALGHDSSYYARIGDN 232
Cdd:PHA03095   216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 427-1275 6.41e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.48  E-value: 6.41e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  427 SENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQL-EDALKDVQKRMYESEGKVKQ 505
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEI----EQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIAS 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  506 MQthflalkehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEC 585
Cdd:TIGR02169  306 LE-------------------RSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  586 GTCEVELERRGRRVVELEGQLKELGAKL---------------ALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESA 650
Cdd:TIGR02169  367 EDLRAELEEVDKEFAETRDELKDYREKLeklkreinelkreldRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  651 QGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELtlknqtlqkdvEKLHADNKLLNQQVHSltvemkt 729
Cdd:TIGR02169  447 ALEIKKQEWKLEQLAADLSKYEqELYDLKEEYDRVEKELSKLQREL-----------AEAEAQARASEERVRG------- 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  730 ryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYtekkQEAERLLAENdkltknvsRLEAVFVAPEKHEKELmglksnIAE 809
Cdd:TIGR02169  509 ----GRAVEEVLKASIQGVHGTVAQLGSVGERY----ATAIEVAAGN--------RLNNVVVEDDAVAKEA------IEL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  810 LKKqlselnKKCGEGQ----EKIRALMSENSSLKK-----------TLSSQYVPAktheeVKASLNSTVEKTNralLEAK 874
Cdd:TIGR02169  567 LKR------RKAGRATflplNKMRDERRDLSILSEdgvigfavdlvEFDPKYEPA-----FKYVFGDTLVVED---IEAA 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  875 KRFDDTSQEVSKlrdENEVLRRN-----LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaAILADHRQGQEEIVS 949
Cdd:TIGR02169  633 RRLMGKYRMVTL---EGELFEKSgamtgGSRAPRGGILFSRSEPAELQRLRERLEGLKRELS---SLQSELRRIENRLDE 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  950 LHAEIKAQKKELDTIQeciklkyAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQK 1029
Cdd:TIGR02169  707 LSQELSDASRKIGEIE-------KEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1030 ELQDrnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQpvplEQVEALKK 1109
Cdd:TIGR02169  780 ALND--LEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI---QELQEQR----IDLKEQIK 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1110 SLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaehlKLKEALEKEVGIMKASLREKEEESQKKTKEVS 1189
Cdd:TIGR02169  851 SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK----------KERDELEAQLRELERKIEELEAQIEKKRKRLS 920

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1190 KLQTEVQTTKQALKNLE---------TREVVDMSKYKATKNDLETQISnlndKLASLNRKYDQACEEKVSAKDEKELLHL 1260
Cdd:TIGR02169  921 ELKAKLEALEEELSEIEdpkgedeeiPEEELSLEDVQAELQRVEEEIR----ALEPVNMLAIQEYEEVLKRLDELKEKRA 996

                          890
                   ....*....|....*
gi 1720432849 1261 SIEQEIRDQKERCDK 1275
Cdd:TIGR02169  997 KLEEERKAILERIEE 1011
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 529-886 9.10e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.09  E-value: 9.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  529 IEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDE-------GRLVEENKRLQKECGTCEVELERRGRRVVE 601
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELeelsrqiSALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  602 LEGQLKELGAKLALSVPTEK-FESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAqhiRPEEHEQLRSR 680
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAeAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE---RLESLERRIAA 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  681 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQ 760
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRR 915

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  761 RYTEKKQEAERLLAENDKLTKNVSRLEAVFvaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL-------MS 833
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEVRIDNLQERL--SEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELgpvnlaaIE 993

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432849  834 ENSSLKK---TLSSQYVPAkthEEVKASLNSTVEKTNRallEAKKRFDDTSQEVSK 886
Cdd:TIGR02168  994 EYEELKErydFLTAQKEDL---TEAKETLEEAIEEIDR---EARERFKDTFDQVNE 1043
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-239 9.94e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 9.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   59 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHVDLQGRTALHDAAMADC 133
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  134 --PSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPT--ICQLLIDRGAD----------------VNSRDKQNRTALML 193
Cdd:PHA03100   119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDinaknrvnyllsygvpINIKDVYGFTPLHY 198

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1720432849  194 GCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 239
Cdd:PHA03100   199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-222 1.03e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.84  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   35 EKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPT 114
Cdd:PHA02874   105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  115 EHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTIcQLLIDrGADVNSRDKQNRTALMLG 194
Cdd:PHA02874   184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                          170       180
                   ....*....|....*....|....*....
gi 1720432849  195 CEYGC-RDAVEVLVKNGADLTLLDALGHD 222
Cdd:PHA02874   262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 761-1351 1.18e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.58  E-value: 1.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  761 RYTEKKQEAERLLAE--------NDK---LTKNVSRLE--------AVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 821
Cdd:COG1196    169 KYKERKEEAERKLEAteenlerlEDIlgeLERQLEPLErqaekaerYRELKEELKELEAELLLLKLRELEAELEELEAEL 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  822 GEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 901
Cdd:COG1196    249 EELEAELEELEAELAELEAELEEL-------RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  902 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEEC 981
Cdd:COG1196    322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  982 ERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKD 1061
Cdd:COG1196    402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1062 LSQKYSDVKSEREKLVEEKAKQA---SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQ 1138
Cdd:COG1196    482 LLEELAEAAARLLLLLEAEADYEgflEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1139 LQQLLENQKNSSVTLAEHLKLK-----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDM 1213
Cdd:COG1196    562 AIEYLKAAKAGRATFLPLDKIRaraalAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVT 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1214 SKYKATKNDLETQISNLNDKLASLNRKydQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ 1293
Cdd:COG1196    642 LAGRLREVTLEGEGGSAGGSLTGGSRR--ELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEE 719

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849 1294 IEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1351
Cdd:COG1196    720 ELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIE 777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 528-1124 4.25e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.65  E-value: 4.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  528 IIEELREQLKDLKG------KYEGASAEVGKLRSQ-----IKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRG 596
Cdd:COG1196    194 ILGELERQLEPLERqaekaeRYRELKEELKELEAEllllkLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  597 RRVVELEGQLKELGAKLALSvptekfESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQ 676
Cdd:COG1196    274 LELEELELELEEAQAEEYEL------LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE------EELEE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  677 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLS 756
Cdd:COG1196    342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  757 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgEGQEKIRALMSENS 836
Cdd:COG1196    422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE--LAEAAARLLLLLEA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  837 SLKKTLSSQYVPAKTHEEVKASLNSTVektnrALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkADYVSLEEHS 916
Cdd:COG1196    500 EADYEGFLEGVKAALLLAGLRGLAGAV-----AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAA--IEYLKAAKAG 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  917 RRmsTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQL 996
Cdd:COG1196    573 RA--TFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVT 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  997 SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL 1076
Cdd:COG1196    651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1720432849 1077 VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1124
Cdd:COG1196    731 EAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-257 5.32e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 5.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   24 RLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALC 103
Cdd:PHA02876   147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  104 LQKLLQYNCPTEHVDLQGRTALHDaamADCPSSIqLLCDHGASVNAKDIDGRTPLVLATQMcrPTICQL---LIDRGADV 180
Cdd:PHA02876   227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849  181 NSRDKQNRTALMLGCEYGC-RDAVEVLVKNGADLTLLDALGHDSSYYARIGD-NLDILNLLKTASENTNkGRELWRKGP 257
Cdd:PHA02876   301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN-ARDYCDKTP 378
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-212 6.12e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 6.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   33 DVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGI---DVATRDsaGRNALHLAAKYGHALCLQKLLQ 109
Cdd:PHA02875    47 DSEAIK-LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIA 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  110 YNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRT 189
Cdd:PHA02875   124 RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCV 203

                          170       180
                   ....*....|....*....|....
gi 1720432849  190 ALM-LGCEYGCRDAVEVLVKNGAD 212
Cdd:PHA02875   204 AALcYAIENNKIDIVRLFIKRGAD 227
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 41-268 9.50e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.43  E-value: 9.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   41 LAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLlqYNCPTEHVDLQ 120
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL--YHFASISDPHA 621

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  121 GRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADV---NSRDKQNRTALMlgcey 197
Cdd:PLN03192   622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkaNTDDDFSPTELR----- 696

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720432849  198 gcrdavEVLVKN--GADLTLLDALGHDSSYYARIGDNLDiLNLLKTASENTNKGRELWRKGPPLQQRNLSHTQ 268
Cdd:PLN03192   697 ------ELLQKRelGHSITIVDSVPADEPDLGRDGGSRP-GRLQGTSSDNQCRPRVSIYKGHPLLRNERCCNE 762
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 67-227 2.55e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 2.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   67 NLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGAS 146
Cdd:PHA02874   103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  147 VNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLVKNgADLTLLDALGHDSSYY 226
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                   .
gi 1720432849  227 A 227
Cdd:PHA02874   261 A 261
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
864-1360 4.42e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.29  E-value: 4.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  864 EKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 942
Cdd:PRK02224   169 ERASDARLGVERVLSDQRGSLDQLKAQiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEE 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  943 GQEEIVSLHAEIKaqkKELDTIQECIKLKYAplarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1022
Cdd:PRK02224   249 RREELETLEAEIE---DLRETIAETEREREE----LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELED 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1023 DLAALQKELQDR-------NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ 1095
Cdd:PRK02224   322 RDEELRDRLEECrvaaqahNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1096 KQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK----NSSVTLAEHLKLKEALEKEVGIMK 1171
Cdd:PRK02224   402 DAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRERVEELE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1172 ASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD--MSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV 1249
Cdd:PRK02224   482 AELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEelIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1250 SAKDEKEllhlsieqEIRDQKERCDKSLTtimELQQRIqESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSS---- 1325
Cdd:PRK02224   562 EAEEEAE--------EAREEVAELNSKLA---ELKERI-ESLERIRTLLAAIADAEDEIERLREKREALAELNDERrerl 629

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 1720432849 1326 GSPTKRQSQLVDTLQQ-RVRDLQQQLADADRQHQEV 1360
Cdd:PRK02224   630 AEKRERKRELEAEFDEaRIEEAREDKERAEEYLEQV 665
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 426-1306 7.16e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 63.84  E-value: 7.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  426 YSENEILKKELETLRTYYDSAKQ----DRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 501
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAEliidLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  502 KVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRL 581
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEK 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  582 QKEcgtcEVELERRGRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL 661
Cdd:pfam02463  324 KKA----EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELEL 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  662 ESVRAQHIRPEEHeqlrsRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEmktryvplrvsEEMK 741
Cdd:pfam02463  400 KSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELK-----------LLKD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  742 KSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 821
Cdd:pfam02463  464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  822 GEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 901
Cdd:pfam02463  544 AISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  902 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEeiVSLHAEIKAQKKELDTIQECIKLKYAPLARLEEC 981
Cdd:pfam02463  624 VVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKAS--LSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  982 ERKFKATEKGLKEQLSEQTH-KCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeeaREAERALSGKADELSKQLK 1060
Cdd:pfam02463  702 KKKEQREKEELKKLKLEAEElLADRVQEAQDKINEELKLLKQKIDEEEEEEE---------KSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1061 DLSQKYSDVKSEREKLVEEKAKQaseILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ 1140
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEEKEEK---LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1141 QLLENQKNSSV-TLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKAT 1219
Cdd:pfam02463  850 KLAEEELERLEeEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1220 KNDLETQISNL----NDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1295
Cdd:pfam02463  930 LLKYEEEPEELlleeADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009

                          890
                   ....*....|.
gi 1720432849 1296 AKDNKITELLN 1306
Cdd:pfam02463 1010 AIIEETCQRLK 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 433-789 7.23e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 7.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  433 KKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTHFLA 512
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE-QLEERIAQLSK 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  513 LKEHLTNEAATGSHRIIE------ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECG 586
Cdd:TIGR02168  755 ELTELEAEIEELEERLEEaeeelaEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  587 TCEVELERRGRRVVELEGQLKELGAKLAlsvptekfesmksSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 666
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIE-------------ELEELIEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  667 QHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHAdnKLLNQqvHSLTVEMKTRYVPLRVSEEMKKSHDv 746
Cdd:TIGR02168  902 EL---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE--RLSEE--YSLTLEEAEALENKIEDDEEEARRR- 973

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720432849  747 nVEDLNKKLSE-------ATQRYTEKKQEAERLLAENDKLTKNVSRLEAV 789
Cdd:TIGR02168  974 -LKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
750-1313 8.87e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.52  E-value: 8.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  750 DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELkkqlselnkkcgegQEKIR 829
Cdd:PRK02224   203 DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDL--------------RETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  830 ALMSENSSLKKTLSSQyvpAKTHEEVKASLNSTVEKTNRALLEAkkrfDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 909
Cdd:PRK02224   269 ETEREREELAEEVRDL---RERLEELEEERDDLLAEAGLDDADA----EAVEARREELEDRDEELRDRLEECRVAAQAHN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  910 VSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATE 989
Cdd:PRK02224   342 EEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREER 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  990 KGLKEQLSEQTHKCRQRDEEVkkgkQENERLRAdlaalqkelqdrnalaeeareaeralSGKADELSKQLKDlsqkysdv 1069
Cdd:PRK02224   422 DELREREAELEATLRTARERV----EEAEALLE--------------------------AGKCPECGQPVEG-------- 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1070 kSEREKLVEEKAKQASEILAAqnllqkqpvpLEQVEALKKSLNGTIEQLkEELRSKQRCLEREQQTVSQLQQLLENQKNS 1149
Cdd:PRK02224   464 -SPHVETIEEDRERVEELEAE----------LEDLEEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRET 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1150 ----SVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykATKNDLET 1225
Cdd:PRK02224   532 ieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLL-----AAIADAED 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1226 QISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIE----QEIRDQKERCDKSLTTIMELQQRIQES----AKQIEAK 1297
Cdd:PRK02224   607 EIERLREKREALAELNDERRERLAEKRERKRELEAEFDeariEEAREDKERAEEYLEQVEEKLDELREErddlQAEIGAV 686

                          570
                   ....*....|....*.
gi 1720432849 1298 DNKITELLNDVERLKQ 1313
Cdd:PRK02224   687 ENELEELEELRERREA 702
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 766-1320 1.15e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.21  E-value: 1.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  766 KQEAERLLAENDKLTKNVSRleAVFVAPEKHEKELMGLKSNIAELKKQLSELN----------KKCGEGQEKIRalmsen 835
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirRRESQSQEDLR------ 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  836 SSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLE-------------------AKKRFDDTSQEVSKLRDENEVLRR 896
Cdd:pfam15921  145 NQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLShegvlqeirsilvdfeeasGKKIYEHDSMSTMHFRSLGSAISK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  897 NLENVQNQ---MKADYVSLEEHSRRMSTVSQS-----LKEAQEANAAILADHrqgQEEIVSLHAEIKAQKKELDTIQeci 968
Cdd:pfam15921  225 ILRELDTEisyLKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQ--- 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  969 klkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERlraDLAALQKELQDRNALAEEAREAERAL 1048
Cdd:pfam15921  299 -------SQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED---KIEELEKQLVLANSELTEARTERDQF 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1049 SGKA----DELSKQLKDLSQKYSDVKSERE---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSL----NGTIEQ 1117
Cdd:pfam15921  369 SQESgnldDQLQKLLADLHKREKELSLEKEqnkRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMksecQGQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1118 LKEELRSKQRCLEReqqtVSQLQQLLENQKNSSVTLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQT 1193
Cdd:pfam15921  449 QMAAIQGKNESLEK----VSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1194 EVQTTKQALKNLETRE--------VVDMSKYKATKND-----LETQISNLNDKLASLNRKYDQACEEKvsAKDEKELLHL 1260
Cdd:pfam15921  525 RVDLKLQELQHLKNEGdhlrnvqtECEALKLQMAEKDkvieiLRQQIENMTQLVGQHGRTAGAMQVEK--AQLEKEINDR 602

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720432849 1261 SIE-QEIRDQKercDKSLTTIMELQQRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ 1320
Cdd:pfam15921  603 RLElQEFKILK---DKKDAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSE 674
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 621-1363 3.33e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 3.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  621 KFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpeehEQLRSRLEQKSGELGKKvseltLKNQ 700
Cdd:TIGR02169  146 DFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLII------DEKRQQLERLRREREKA-----ERYQ 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  701 TLQKDVEKLHADNKLLNQQVHsltvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLT 780
Cdd:TIGR02169  215 ALLKEKREYEGYELLKEKEAL----------------ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  781 KNVSRL---EAVFVAPEKHE--KELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEV 855
Cdd:TIGR02169  279 KKIKDLgeeEQLRVKEKIGEleAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  856 KASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLenvqNQMKADYVSLEEHSRRMstvSQSLKEAQEANAA 935
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI----NELKRELDRLQEELQRL---SEELADLNAAIAG 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  936 ILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQ 1015
Cdd:TIGR02169  432 IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRA 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1016 ENERLRADLAALQKELQDRNALAEEAREAERALSG---------------KADELSKQLK-------------------- 1060
Cdd:TIGR02169  512 VEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGnrlnnvvveddavakEAIELLKRRKagratflplnkmrderrdls 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1061 ---------------DLSQKY--------------SDVKSEREKLVE-----------EKA--------KQASEILAAQN 1092
Cdd:TIGR02169  592 ilsedgvigfavdlvEFDPKYepafkyvfgdtlvvEDIEAARRLMGKyrmvtlegelfEKSgamtggsrAPRGGILFSRS 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1093 LLQKQPVPLEQVEALKKSLNG------TIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLK-EALEK 1165
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSlqselrRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDlSSLEQ 751

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1166 EVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-MSKYKATKNDLETQISNLNDKLASLNRKYDQA 1244
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAeLSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1245 CEEKVSAKDEKELLhlsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYS 1324
Cdd:TIGR02169  832 EKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 1720432849 1325 SGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAI 1363
Cdd:TIGR02169  908 LEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 291-1150 3.85e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 3.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  291 IENEDLREKLRKIqqEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDH 370
Cdd:TIGR02169  211 ERYQALLKEKREY--EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEE 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  371 pgpgsypSNR-KEDMLHKQGQMYTTEPQCASpgipphmhsrSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQD 449
Cdd:TIGR02169  289 -------QLRvKEKIGELEAEIASLERSIAE----------KERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  450 RLKFQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSH 526
Cdd:TIGR02169  352 RDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQEELQRLSEELAD-----LN 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  527 RIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQL 606
Cdd:TIGR02169  427 AAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE-------AEAQA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  607 KELGAKLALSVPTEKfesMKSSLSNDINEKVKRLAEVGRDY----ESAQG-EIRQLKRDLESVRAQHIrpeehEQLRSRl 681
Cdd:TIGR02169  500 RASEERVRGGRAVEE---VLKASIQGVHGTVAQLGSVGERYataiEVAAGnRLNNVVVEDDAVAKEAI-----ELLKRR- 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  682 eqksgelgkKVSELTL----KNQTLQKDVEKLHADNKL---LNqqvhslTVEMKTRYVP---------LRVS------EE 739
Cdd:TIGR02169  571 ---------KAGRATFlplnKMRDERRDLSILSEDGVIgfaVD------LVEFDPKYEPafkyvfgdtLVVEdieaarRL 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  740 MKKSHDVNVE-DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQLSELN 818
Cdd:TIGR02169  636 MGKYRMVTLEgELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGL-------KRELSSLQSELRRIENRLDELS 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  819 KKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRN 897
Cdd:TIGR02169  709 QELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEAlNDLEARL 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  898 LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplAR 977
Cdd:TIGR02169  789 SHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN------GK 862

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  978 LEECERKFKATEKGLkeqlseqthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1057
Cdd:TIGR02169  863 KEELEEELEELEAAL-----------RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE 931

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1058 QLKDLsqkysdvkserEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE------ELRSKQRCLER 1131
Cdd:TIGR02169  932 ELSEI-----------EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEvlkrldELKEKRAKLEE 1000

                          890
                   ....*....|....*....
gi 1720432849 1132 EQQTVSQLQQLLENQKNSS 1150
Cdd:TIGR02169 1001 ERKAILERIEEYEKKKREV 1019
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 672-1349 4.04e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.52  E-value: 4.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  672 EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDveklhadnklLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDL 751
Cdd:TIGR00618  176 DQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC----------TPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  752 NKKLSEATQRyTEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL 831
Cdd:TIGR00618  246 TQKREAQEEQ-LKKQQLLKQLRARIEELRAQEAVLEE-----TQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  832 MSENSSLKKTLSSQYVPAKTHEEVKASLNStvektnraLLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQnQMKADYVS 911
Cdd:TIGR00618  320 MRSRAKLLMKRAAHVKQQSSIEEQRRLLQT--------LHSQEIHIRDAHEVATSIREISCQQHTLTQHIH-TLQQQKTT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  912 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKY----APLARLEECERKFKA 987
Cdd:TIGR00618  391 LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAqcekLEKIHLQESAQSLKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  988 TEKGL--KEQLSEQTHKCRQRDEEVKKGKQENER--------------LRADLAALQKELQDRNALAEEAREAERALSGK 1051
Cdd:TIGR00618  471 REQQLqtKEQIHLQETRKKAVVLARLLELQEEPCplcgscihpnparqDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1052 ADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELR---SKQRC 1128
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQpeqDLQDV 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 LEREQQTVSQLQQLLENQKNSSVTLA-----EHLKLKEALEKEVGimkASLREKEEESQKKTKEVSKLQTEVQTTKQALK 1203
Cdd:TIGR00618  631 RLHLQQCSQELALKLTALHALQLTLTqervrEHALSIRVLPKELL---ASRQLALQKMQSEKEQLTYWKEMLAQCQTLLR 707

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1204 NLET------REVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSA---KDEKELLHLSIEQEIRDQKERC 1273
Cdd:TIGR00618  708 ELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLKARTEAhfnNNEEVTAALQTGAELSHLAAEI 787

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1274 DKSLTTIMELQQRIQESAKQIEAK-----DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQ 1348
Cdd:TIGR00618  788 QFFNRLREEDTHLLKTLEAEIGQEipsdeDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQE 867


                   .
gi 1720432849 1349 Q 1349
Cdd:TIGR00618  868 Q 868
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 55-209 4.20e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.66  E-value: 4.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   55 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHdAAMADCP 134
Cdd:PHA02878   168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH-ISVGYCK 246

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849  135 SS--IQLLCDHGASVNAKD-IDGRTPLVLATQmcRPTICQLLIDRGADVNSRDKQNRTAL-MLGCEYGCRDAVEVLVKN 209
Cdd:PHA02878   247 DYdiLKLLLEHGVDVNAKSyILGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISN 323
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 636-1319 2.58e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.70  E-value: 2.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  636 KVKRLAEVGRDYESAQGEIRQLKR-----DLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 710
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFgyksdETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDR 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  711 ADNKLLNQQvhsLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNK--KLSEATQRYTEKKQEAERLLAE---NDKLTKNVSR 785
Cdd:pfam12128  322 SELEALEDQ---HGAFLDADIETAAADQEQLPSWQSELENLEErlKALTGKHQDVTAKYNRRRSKIKeqnNRDIAGIKDK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  786 LEAVFVAPEK-HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSEnssLKKTLSSqyvpAKTHEEVKASLNSTVE 864
Cdd:pfam12128  399 LAKIREARDRqLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGE---LKLRLNQ----ATATPELLLQLENFDE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  865 KTNRALLEAKKRFddtsQEVSKLRDENEVLRRNLENVQnqmkadyVSLEEHSRRMSTVSQSLKEAQEanaailadhrQGQ 944
Cdd:pfam12128  472 RIERAREEQEAAN----AEVERLQSELRQARKRRDQAS-------EALRQASRRLEERQSALDELEL----------QLF 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  945 EEIVSLHAEIKaqkKELDTIQECIKlKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1024
Cdd:pfam12128  531 PQAGTLLHFLR---KEAPDWEQSIG-KVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERL 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1025 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVP-LEQ 1103
Cdd:pfam12128  607 DKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANErLNS 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1104 VEALKKSLNGTIEQLKEELRSKQRCLEREQQtvsqlQQLLENQKNSSVTLAehlKLKEALEKEVGIMKASLREKEEESQK 1183
Cdd:pfam12128  687 LEAQLKQLDKKHQAWLEEQKEQKREARTEKQ-----AYWQVVEGALDAQLA---LLKAAIAARRSGAKAELKALETWYKR 758

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1184 KTKE-------VSKLQTEVQTTKQALKNLETRE--------------VVDMSKYKATKNDLETQISNLNDKLASLnrkyd 1242
Cdd:pfam12128  759 DLASlgvdpdvIAKLKREIRTLERKIERIAVRRqevlryfdwyqetwLQRRPRLATQLSNIERAISELQQQLARL----- 833

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849 1243 QACEEKVSAKDEKELlhlsieQEIRDQKERCDKSLTTIMELQQRIQE--SAKQIEAKDNKITELLNDVERLKQALNGLS 1319
Cdd:pfam12128  834 IADTKLRRAKLEMER------KASEKQQVRLSENLRGLRCEMSKLATlkEDANSEQAQGSIGERLAQLEDLKLKRDYLS 906
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 429-1279 2.91e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.91  E-value: 2.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  429 NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalalecervkedsdeqikqLEDALKDVQKRMYESegKVKQMQT 508
Cdd:TIGR01612  944 KEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINE---------------------LDKAFKDASLNDYEA--KNNELIK 1000

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  509 HFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGEFKRDEGRLVEE-NKRLQKECG 586
Cdd:TIGR01612 1001 YFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSiYNIIDEIEKEIGKNIELlNKEILEEAE 1080

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  587 TCEVELE--RRGRRVVELEGQLKELGAKLALSVptEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESV 664
Cdd:TIGR01612 1081 INITNFNeiKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDV 1158

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  665 RAQHIRPEEHEQLRSRLEQKSGELGKK------VSELTLKNQTLQKD---VEKLHADNKLLNQQVHSLTVEMKTRyvPLR 735
Cdd:TIGR01612 1159 ADKAISNDDPEEIEKKIENIVTKIDKKkniydeIKKLLNEIAEIEKDktsLEEVKGINLSYGKNLGKLFLEKIDE--EKK 1236

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  736 VSEEMKKSHDVNVEDLNkKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELmglkSNIAELKKQLS 815
Cdd:TIGR01612 1237 KSEHMIKAMEAYIEDLD-EIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENI----SDIREKSLKII 1311

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  816 ELNKKcgegqekiralMSENSSLKKTLSSQYVPAKTH-EEVKASLNSTVEKTN-RALLEAKKRFDDTSQEVSKLRDENEV 893
Cdd:TIGR01612 1312 EDFSE-----------ESDINDIKKELQKNLLDAQKHnSDINLYLNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKN 1380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  894 LRRNLENVQNQMKA--DYVSLEE-HSRRMSTVSQSLKEAQEANAAILADHrqgqeeIVSLHAEIKAQKKELDTIQECIKL 970
Cdd:TIGR01612 1381 IKDELDKSEKLIKKikDDINLEEcKSKIESTLDDKDIDECIKKIKELKNH------ILSEESNIDTYFKNADENNENVLL 1454

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  971 KYaplarlEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLradlaalqKELQDRNALAEEareaeralsg 1050
Cdd:TIGR01612 1455 LF------KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGC--------KDEADKNAKAIE---------- 1510

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLK----DLSQKYSDVKSEREKlveEKAKQASEILAAQNLLQKQPVPLEQvealkkslnGTIEQLKEELRSKQ 1126
Cdd:TIGR01612 1511 KNKELFEQYKkdvtELLNKYSALAIKNKF---AKTKKDSEIIIKEIKDAHKKFILEA---------EKSEQKIKEIKKEK 1578

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1127 RCLERE-------QQTVSQLQQLLENQKNSSVTLA-------EHLKLKEALEKEVGIMkaSLREKEEESQKKTKEVSKLQ 1192
Cdd:TIGR01612 1579 FRIEDDaakndksNKAAIDIQLSLENFENKFLKISdikkkinDCLKETESIEKKISSF--SIDSQDTELKENGDNLNSLQ 1656

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1193 TEVQTTKQALKNLETRevvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEEKVS--AKDEKELLHlSIEQEIRDQK 1270
Cdd:TIGR01612 1657 EFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKeiAIANKEEIE-SIKELIEPTI 1727


                   ....*....
gi 1720432849 1271 ERCDKSLTT 1279
Cdd:TIGR01612 1728 ENLISSFNT 1736
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 481-1078 3.50e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.41  E-value: 3.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  481 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQS 560
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-----LEELELELEEAQAEEYELLAELARLEQDIARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  561 EMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRL 640
Cdd:COG1196    308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL------AEAEEALLEAEAELAEAEEEL 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  641 AEVGRDYESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQV 720
Cdd:COG1196    382 EELAEELLEALRAAAELAAQLEELEEAE---EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  721 HSLTVEMKTRYVPLRVSEEmkkshdvNVEDLNKKLSEATQRYTEKKQEAE------------RLLAENDKLTKNVSRLEA 788
Cdd:COG1196    459 EALLELLAELLEEAALLEA-------ALAELLEELAEAAARLLLLLEAEAdyegflegvkaaLLLAGLRGLAGAVAVLIG 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  789 VFVAPEKHEKELMGlkSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNR 868
Cdd:COG1196    532 VEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLR 609

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  869 ALLEAKKRFDDTSQevsklrdENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 948
Cdd:COG1196    610 EADARYYVLGDTLL-------GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELE 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  949 SLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1028
Cdd:COG1196    683 ELAERLAEEELELEEALL----------AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA 752

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720432849 1029 KELQDRNALAEEAREAERALSGK--------------ADELSKQLKDLSQKYSDVKSEREKLVE 1078
Cdd:COG1196    753 LEELPEPPDLEELERELERLEREiealgpvnllaieeYEELEERYDFLSEQREDLEEARETLEE 816
Ank_4 pfam13637
Ankyrin repeats (many copies);
55-108 3.69e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.69e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720432849   55 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLL 108
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 137-234 3.85e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 3.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  137 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLL 216
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|....*...
gi 1720432849  217 DALGHDSSYYARIGDNLD 234
Cdd:PTZ00322   178 GANAKPDSFTGKPPSLED 195
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-174 4.03e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 4.03e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720432849  121 GRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLI 174
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 68-247 4.60e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 4.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   68 LECLNAILTHGIDVATR--DSA---------GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSS 136
Cdd:PHA02875     4 VALCDAILFGELDIARRllDIGinpnfeiydGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  137 IQLLCDHGASVNakDI---DGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADL 213
Cdd:PHA02875    84 VEELLDLGKFAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1720432849  214 TLLDALGHDSSYYARIGDNLDILNLLKTASENTN 247
Cdd:PHA02875   162 DIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 430-709 5.40e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 5.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  430 EILKKELETLRTYYDSAKQDRLKFQNE---LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQM 506
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEieeLEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  507 QTHFLALKEHLTNEAATGS--HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKE 584
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAatERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE 895

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  585 CGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDINEKVKRLAEVGRD--------YESAQGEIRQ 656
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLA------QLELRLEGLEVRIDNLQERLSEEYSLtleeaealENKIEDDEEE 969

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849  657 LKRDLESVRAQHIR--------PEEHEQLRSRLEqksgELGKKVSELTLKNQTLQKDVEKL 709
Cdd:TIGR02168  970 ARRRLKRLENKIKElgpvnlaaIEEYEELKERYD----FLTAQKEDLTEAKETLEEAIEEI 1026
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
480-695 1.49e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 1.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  480 EQIKQLEDALKDVQK--RMYESEGKVKQMQTHFLALKEHLTNEAATgshRIIEELREQLKDLKGKYEGASAEVGKLRSQI 557
Cdd:COG4913    249 EQIELLEPIRELAERyaAARERLAELEYLRAALRLWFAQRRLELLE---AELEELRAELARLEAELERLEARLDALREEL 325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  558 kqsEMLVGEFKRDEGRLVEenkRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSVPT-----EKFESMKSSLSND 632
Cdd:COG4913    326 ---DELEAQIRGNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalrAEAAALLEALEEE 399

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720432849  633 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRLEQksgELGKKVSEL 695
Cdd:COG4913    400 LEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNiPARLLALRDALAE---ALGLDEAEL 460
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 947-1359 1.67e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.80  E-value: 1.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  947 IVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAA 1026
Cdd:TIGR04523   28 ANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSK 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1027 LQKELQDRNalaeeareaeralsgkadelsKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEA 1106
Cdd:TIGR04523  108 INSEIKNDK---------------------EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1107 LKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTK 1186
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTT 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1187 EVSKLQTEVQTTKQALKNLETR---EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV-----SAKDEKELL 1258
Cdd:TIGR04523  247 EISNTQTQLNQLKDEQNKIKKQlseKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELkselkNQEKKLEEI 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1259 HLSI---EQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQL 1335
Cdd:TIGR04523  327 QNQIsqnNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKL 406

                          410       420
                   ....*....|....*....|....
gi 1720432849 1336 VDTLQQRVRDLQQQLADADRQHQE 1359
Cdd:TIGR04523  407 NQQKDEQIKKLQQEKELLEKEIER 430
PRK01156 PRK01156
chromosome segregation protein; Provisional
 625-1214 3.91e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 54.91  E-value: 3.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  625 MKSSLSNDINEKVKRLAEVgRDYESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLEQKSGEL---GKKVSELTLKNQT 701
Cdd:PRK01156   140 MDSLISGDPAQRKKILDEI-LEINSLERNYDKLKDVIDMLRAE---ISNIDYLEEKLKSSNLELeniKKQIADDEKSHSI 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  702 LQKDVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLA-ENDKLT 780
Cdd:PRK01156   216 TLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKiINDPVY 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  781 KNVSRLEAVFvapeKHEKELMGLKSNIAELKKQLS--ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKAS 858
Cdd:PRK01156   292 KNRNYINDYF----KYKNDIENKKQILSNIDAEINkyHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNS 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  859 LNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyVSLEEHSRRMSTVSQSL------KEAQEA 932
Cdd:PRK01156   368 YLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEIN---VKLQDISSKVSSLNQRIralrenLDELSR 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  933 NAAILADH-----------RQGQEEIVS--------LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLK 993
Cdd:PRK01156   445 NMEMLNGQsvcpvcgttlgEEKSNHIINhynekksrLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKI 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  994 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDR------NALAEEAREAERALSGKADELSKQLKDLSQKYS 1067
Cdd:PRK01156   525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSkrtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQ 604

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1068 DVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1147
Cdd:PRK01156   605 EIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLK 684

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849 1148 NSSVTLAEHLKLKEALEKEVGImkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNL-ETREVVDMS 1214
Cdd:PRK01156   685 KSRKALDDAKANRARLESTIEI----LRTRINELSDRINDINETLESMKKIKKAIGDLkRLREAFDKS 748
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 15-221 4.32e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 54.70  E-value: 4.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   15 SAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGIDVATrdsaG 88
Cdd:TIGR00870   11 ESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCRGAV----G 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   89 RNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASVNAK----- 150
Cdd:TIGR00870   83 DTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASVPARacgdf 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  151 -----DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY----------------G 198
Cdd:TIGR00870  163 fvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmynfalslldK 242

                          250       260
                   ....*....|....*....|....
gi 1720432849  199 CRDAVEV-LVKNGADLTLLDALGH 221
Cdd:TIGR00870  243 LRDSKELeVILNHQGLTPLKLAAK 266
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-191 4.75e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   63 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 134
Cdd:cd22192     25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849  135 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:cd22192    103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 869-1090 1.23e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  869 ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 948
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  949 SLHAEIKAQKKEL-DTIQECIKLKYAPLARL----EECERKFKATE--KGLKEQLSEQTHKCRQRDEEVKKGKQENERLR 1021
Cdd:COG4942     94 ELRAELEAQKEELaELLRALYRLGRQPPLALllspEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAER 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720432849 1022 ADLAALQKELQDR----NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1090
Cdd:COG4942    174 AELEALLAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
PRK01156 PRK01156
chromosome segregation protein; Provisional
 863-1354 1.24e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 53.37  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  863 VEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyvSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 942
Cdd:PRK01156   161 INSLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKK----QIADDEKSHSITLKEIERLSIEYNNAMDDYNN 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  943 GQEEIvslhAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1022
Cdd:PRK01156   237 LKSAL----NELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQ 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1023 DLAALQKELQDRNALAEEAREAERALS------GKADELSKQLKDLSQKYSD-------VKSEREKLVEEKAKQASEILA 1089
Cdd:PRK01156   313 ILSNIDAEINKYHAIIKKLSVLQKDYNdyikkkSRYDDLNNQILELEGYEMDynsylksIESLKKKIEEYSKNIERMSAF 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1090 AQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS---KQRCLEREQQTVSQLQQLLENQKNSSVTlAEHLKlKEALEKE 1166
Cdd:PRK01156   393 ISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSlnqRIRALRENLDELSRNMEMLNGQSVCPVC-GTTLG-EEKSNHI 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1167 VGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACE 1246
Cdd:PRK01156   471 INHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEE 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1247 ekvsAKDEKELLHLSIEQEIRDQ--KERCDKSLTTIMELQQRIQESAKQI---EAKDNKITELLNDVERLKQALNGLSQL 1321
Cdd:PRK01156   551 ----IKNRYKSLKLEDLDSKRTSwlNALAVISLIDIETNRSRSNEIKKQLndlESRLQEIEIGFPDDKSYIDKSIREIEN 626

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1720432849 1322 TYSSGSPTKRQSQ----LVDTLQQRVRDLQQQLADAD 1354
Cdd:PRK01156   627 EANNLNNKYNEIQenkiLIEKLRGKIDNYKKQIAEID 663
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
924-1386 1.44e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 1.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  924 QSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLkYAPLARLEECERKFKATEKGLkEQLSEQTHKC 1003
Cdd:COG4717     81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL-LPLYQELEALEAELAELPERL-EELEERLEEL 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1004 RQRDEEVKKGKQENERLRADLAALQKELQDRNALA-EEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK 1082
Cdd:COG4717    159 RELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEA 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1083 Q---------------ASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1147
Cdd:COG4717    239 AaleerlkearlllliAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEE 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1148 NSSVTLAEHLKLKEALEKEvgiMKASLREKEEESQKKTKEVSKLQTEVQttkqaLKNLETREVVDMSKYKAtkndletqi 1227
Cdd:COG4717    319 EELEELLAALGLPPDLSPE---ELLELLDRIEELQELLREAEELEEELQ-----LEELEQEIAALLAEAGV--------- 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1228 snlnDKLASLNRKYDQAcEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTimELQQRIQESAKQIEAKDNKITELLND 1307
Cdd:COG4717    382 ----EDEEELRAALEQA-EEYQELKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREE 454

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849 1308 VERLKQALNGLsqltyssgsptkRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYrtHLLSAAQGHMDEDVQAALLQ 1386
Cdd:COG4717    455 LAELEAELEQL------------EEDGELAELLQELEELKAELRELAEEWAALKLAL--ELLEEAREEYREERLPPVLE 519
46 PHA02562
endonuclease subunit; Provisional
 479-710 1.46e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 52.71  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  479 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK 558
Cdd:PHA02562   187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  559 QSEMLVGEFKRDEgRLVEENkrlqKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMKsSLSNDINEKVK 638
Cdd:PHA02562   266 KIKSKIEQFQKVI-KMYEKG----GVCPTCTQQISEGPDRITKIKDKLKELQHSLEKL--DTAIDELE-EIMDEFNEQSK 337

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720432849  639 RLAEVgrdyesaQGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 710
Cdd:PHA02562   338 KLLEL-------KNKISTNKQSLITLVDKAKKVKaAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKY 403
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 629-1256 1.52e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  629 LSNDINEKVKRLAEVGRDYESAQGEIR-QLKRDLESVraQHIRPEEHEQLRSRLEQ------KSGELGKKVSELTLKNQT 701
Cdd:pfam05483  188 LNNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKI--QHLEEEYKKEINDKEKQvsllliQITEKENKMKDLTFLLEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  702 LQKDVEKLHADNKL-------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQrytEKKQEAERLLA 774
Cdd:pfam05483  266 SRDKANQLEEKTKLqdenlkeLIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTE---EKEAQMEELNK 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  775 ENDKLTKNVSRLEAVFVAPEKHEK-ELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpaKTHE 853
Cdd:pfam05483  343 AKAAHSFVVTEFEATTCSLEELLRtEQQRLEKNEDQLKIITMELQKKSSELEEMTKF-------------------KNNK 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  854 EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL----RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEA 929
Cdd:pfam05483  404 EVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  930 QEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEE 1009
Cdd:pfam05483  484 KLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1010 VK--KGKQENERLRADLAALQKELQDRnalaeeareaerALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1087
Cdd:pfam05483  564 VKckLDKSEENARSIEYEVLKKEKQMK------------ILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1088 LAAQnllqkqpvplEQVEALKKSLNGTIEQLKEELRSKQRclEREQQTVSQlQQLLENQKNSSVTLAEHLKLKEALEKEV 1167
Cdd:pfam05483  632 NAYE----------IKVNKLELELASAKQKFEEIIDNYQK--EIEDKKISE-EKLLEEVEKAKAIADEAVKLQKEIDKRC 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1168 gimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE 1247
Cdd:pfam05483  699 ---QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQ-------SSAKAALEIELSNIKAELLSLKKQLEIEKEE 768


                   ....*....
gi 1720432849 1248 KVSAKDEKE 1256
Cdd:pfam05483  769 KEKLKMEAK 777
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 765-1360 1.57e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.92  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  765 KKQEAERLLAEND------KLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-LMSENSS 837
Cdd:pfam12128  219 NRQQVEHWIRDIQaiagimKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQlLRTLDDQ 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  838 LKKTLSSQYVPAKTHEEVKASLNSTVEktnrALLEAKKRFDDTSQEVSKLRDENEVLRRN-LENVQNQMKAdyvsLEEHS 916
Cdd:pfam12128  299 WKEKRDELNGELSAADAAVAKDRSELE----ALEDQHGAFLDADIETAAADQEQLPSWQSeLENLEERLKA----LTGKH 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  917 RRMSTVSQSLKEA-QEANAAILADHRQGQ----EEIVSLHAEIKAQKKELDtiQECIKLKYAPLARLEECERKFKATEKG 991
Cdd:pfam12128  371 QDVTAKYNRRRSKiKEQNNRDIAGIKDKLakirEARDRQLAVAEDDLQALE--SELREQLEAGKLEFNEEEYRLKSRLGE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  992 LKEQL------SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELqdrnalaeeareaeRALSGKADELSKQLKDLSQK 1065
Cdd:pfam12128  449 LKLRLnqatatPELLLQLENFDERIERAREEQEAANAEVERLQSEL--------------RQARKRRDQASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1066 YSDVKSEREKLVEEKAKQASEILAaqnLLQKQPVPLEQVEA--LKKSLNGTIEqLKEELRSKQRCLEREQQTVS-QLQQL 1142
Cdd:pfam12128  515 LEERQSALDELELQLFPQAGTLLH---FLRKEAPDWEQSIGkvISPELLHRTD-LDPEVWDGSVGGELNLYGVKlDLKRI 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1143 lenQKNSSVTLAEHLKLK-EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdmskykatkn 1221
Cdd:pfam12128  591 ---DVPEWAASEEELRERlDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLR----------- 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1222 DLETQISNLNDKLA-SLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKErcdKSLTTIMELQQRIQESakqIEAKDNK 1300
Cdd:pfam12128  657 RLFDEKQSEKDKKNkALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKE---QKREARTEKQAYWQVV---EGALDAQ 730

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720432849 1301 I----TELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEV 1360
Cdd:pfam12128  731 LallkAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEV 794
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-240 1.62e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.53  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  137 IQLLCDHGASVNAKDIDGRTPL--VLATQMCRPT---ICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLVK 208
Cdd:PHA02798    54 VKLFINLGANVNGLDNEYSTPLctILSNIKDYKHmldIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1720432849  209 NGADLTLLDALGHDS-SYYARIGDNLDIlNLLK 240
Cdd:PHA02798   134 NGADTTLLDKDGFTMlQVYLQSNHHIDI-EIIK 165
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
479-670 1.89e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 52.61  E-value: 1.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  479 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLA---LKEHLTNEAATGS-HRIIEELREQLKDLK---GKYEGASAEVG 551
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREAlqrLAEYSWDEIDVASaEREIAELEAELERLDassDDLAALEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  552 KLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVelEGQLKELGAKLALSVPTEKFESMKSSLSN 631
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR--LELRALLEERFAAALGDAVERELRENLEE 773

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1720432849  632 DInekvkrlaevgrdyESAQGEIRQLKRDLESVRAQHIR 670
Cdd:COG4913    774 RI--------------DALRARLNRAEEELERAMRAFNR 798
Ank_2 pfam12796
Ankyrin repeats (3 copies);
158-239 2.27e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 2.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  158 LVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGAdltlLDALGHDSS--YYARIGDNLDI 235
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 1720432849  236 LNLL 239
Cdd:pfam12796   77 VKLL 80
PRK01156 PRK01156
chromosome segregation protein; Provisional
 777-1355 2.28e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.21  E-value: 2.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  777 DKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSqyvpAKTHEEVK 856
Cdd:PRK01156   176 DMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMK 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  857 ASLNSTVEKTNRAL---LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN 933
Cdd:PRK01156   252 NRYESEIKTAESDLsmeLEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  934 AAILADHRQgQEEIVSLHAEIKAQKKELDTIQEciklKYAPLArleeceRKFKATEKGLKEQLSEQTHKCRQRDEEVKKG 1013
Cdd:PRK01156   332 SVLQKDYND-YIKKKSRYDDLNNQILELEGYEM----DYNSYL------KSIESLKKKIEEYSKNIERMSAFISEILKIQ 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1014 KQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQK---------YSDVKSER--EKLVEEKAK 1082
Cdd:PRK01156   401 EIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttLGEEKSNHiiNHYNEKKSR 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1083 QASEILAAQNLLQKQPVPLEQVEALKKSLNGtieqlkeelrSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE-HLKLKE 1161
Cdd:PRK01156   481 LEEKIREIEIEVKDIDEKIVDLKKRKEYLES----------EEINKSINEYNKIESARADLEDIKIKINELKDkHDKYEE 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1162 ALEKEVGIMKASLREKEEE-----SQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1236
Cdd:PRK01156   551 IKNRYKSLKLEDLDSKRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANN 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1237 LNRKYDQAcEEKVSAKDEkellhlsIEQEIRDQKERCDKslttimelQQRIQESAKQIEAKDNKITELLNDVERLKQALN 1316
Cdd:PRK01156   631 LNNKYNEI-QENKILIEK-------LRGKIDNYKKQIAE--------IDSIIPDLKEITSRINDIEDNLKKSRKALDDAK 694

                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 1720432849 1317 glsqltyssgSPTKRQSQLVDTLQQRVRDLQQQLADADR 1355
Cdd:PRK01156   695 ----------ANRARLESTIEILRTRINELSDRINDINE 723
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1008-1209 2.50e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 2.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1008 EEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1087
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1088 LAAQNLLQKQPV---PLEQVEALKKSLNGT-----------IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-SVT 1152
Cdd:COG4942    100 EAQKEELAELLRalyRLGRQPPLALLLSPEdfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAElEAL 179

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1153 LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1209
Cdd:COG4942    180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 653-1313 2.80e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.28  E-value: 2.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  653 EIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQtLQKDVEKLHADNKLLNQQVHSLtveMKTRYV 732
Cdd:pfam02463  184 NLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDY-LKLNEERIDLLQELLRDEQEEI---ESSKQE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  733 PLRVSEEMKKSHDVNVEDLN-KKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFV--APEKHEKELMGLKSNIAE 809
Cdd:pfam02463  260 IEKEEEKLAQVLKENKEEEKeKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESekEKKKAEKELKKEKEEIEE 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  810 LKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRD 889
Cdd:pfam02463  340 LEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLED 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  890 ENEVLRRNLENVQNqmkadyvsleehsrrmstVSQSLKEAQEANAAILADHRQGQEEI-VSLHAEIKAQKKELDTIQECI 968
Cdd:pfam02463  420 LLKEEKKEELEILE------------------EEEESIELKQGKLTEEKEELEKQELKlLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  969 KLKYapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERAL 1048
Cdd:pfam02463  482 LQEQ--LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADE 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1049 SGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQA-----SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELR 1123
Cdd:pfam02463  560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAvleidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1124 SKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQT--TKQA 1201
Cdd:pfam02463  640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKklKLEA 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1202 LKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIM 1281
Cdd:pfam02463  720 EELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQ 799

                          650       660       670
                   ....*....|....*....|....*....|..
gi 1720432849 1282 ELQQRIQESAKQIEAKDNKITELLNDVERLKQ 1313
Cdd:pfam02463  800 EEELRALEEELKEEAELLEEEQLLIEQEEKIK 831
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 794-1368 3.32e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.65  E-value: 3.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  794 EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSS-------LKKTLSSQYVPAKTHE-------EVKASL 859
Cdd:pfam05483  109 QENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNAtrhlcnlLKETCARSAEKTKKYEyereetrQVYMDL 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  860 NSTVEKTNRALLEAKKRFDDTSQEVS-KLRDENEVL-------RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQE 931
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKIqhleeeyKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  932 ANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplarleecerKFKATEKGLKEQLSEQTHKCRQRDEEVK 1011
Cdd:pfam05483  269 KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQ--------------RSMSTQKALEEDLQIATKTICQLTEEKE 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1012 KGKQENERLRADLAALQKELQdrnalaeeareaerALSGKADELskqlkdlsqkysdVKSEREKLveEKAKQASEILAAQ 1091
Cdd:pfam05483  335 AQMEELNKAKAAHSFVVTEFE--------------ATTCSLEEL-------------LRTEQQRL--EKNEDQLKIITME 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1092 nlLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaEHLKLKEALEKEVGIMK 1171
Cdd:pfam05483  386 --LQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQ-------ELIFLLQAREKEIHDLE 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1172 ASLREKEEESQKKTKEVSKLQTEVQttKQALKNLETREVVDMSKYKATKNDLETQ------------ISNLNDKLASLNR 1239
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELE--KEKLKNIELTAHCDKLLLENKELTQEASdmtlelkkhqedIINCKKQEERMLK 534

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1240 KYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1319
Cdd:pfam05483  535 QIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELH 614

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 1720432849 1320 QLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHL 1368
Cdd:pfam05483  615 QENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEI 663
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 434-1321 3.79e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.59  E-value: 3.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  434 KELETLRTYYDSAKQDRLKFQNELAHKVAEckalaLECERvkedsdEQIKQLEDALKDVQKRMYESEgkvkQMQTHFLAL 513
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQ-----LESSR------EIVKSYENELDPLKNRLKEIE----HNLSKIMKL 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  514 KEHLTNEAATGSHRiiEELREQLKDLKGK-YEGASAEVGKLRsqikqsemlvgEFKRDEGRLVEEnkrlqkECGTCEVEL 592
Cdd:TIGR00606  268 DNEIKALKSRKKQM--EKDNSELELKMEKvFQGTDEQLNDLY-----------HNHQRTVREKER------ELVDCQREL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  593 ERRGRRVVELEGQLKELgaklalsvpteKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpE 672
Cdd:TIGR00606  329 EKLNKERRLLNQEKTEL-----------LVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIK---N 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  673 EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhslTVEMKTRYVPLRVSE-EMKKSHDVNVEDL 751
Cdd:TIGR00606  395 FHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGR-----TIELKKEILEKKQEElKFVIKELQQLEGS 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  752 NKKLSEATQRYTekKQEAERLLAENDKLT-------KNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEG 824
Cdd:TIGR00606  470 SDRILELDQELR--KAERELSKAEKNSLTetlkkevKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDK 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  825 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 904
Cdd:TIGR00606  548 DEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDK 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  905 MkADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLhaeikaqkkeLDTIQECIKLkyaplarleeCERK 984
Cdd:TIGR00606  628 L-FDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQL----------TDENQSCCPV----------CQRV 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  985 FKaTEKGLKEQLSEQTHKCR-------QRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1057
Cdd:TIGR00606  687 FQ-TEAELQEFISDLQSKLRlapdklkSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKN 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1058 QLKDLSQKYSDVKSErEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNG--TIEQLKEELRSKQRCLEREQQT 1135
Cdd:TIGR00606  766 DIEEQETLLGTIMPE-EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLdrTVQQVNQEKQEKQHELDTVVSK 844

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1136 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK-------QALKNLETR 1208
Cdd:TIGR00606  845 IELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKeqdspleTFLEKDQQE 924

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1209 EVVDMSKYKATK-------NDLETQISNLNDKLASLNRKYDQACEEKVSAKdEKELLHLSIE-QEIRDQKERCDKSLTTI 1280
Cdd:TIGR00606  925 KEELISSKETSNkkaqdkvNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQK-ETELNTVNAQlEECEKHQEKINEDMRLM 1003

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....
gi 1720432849 1281 MEL--QQRIQESAKQIEAKDNKITELLNDVER-LKQALNGLSQL 1321
Cdd:TIGR00606 1004 RQDidTQKIQERWLQDNLTLRKRENELKEVEEeLKQHLKEMGQM 1047
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
456-942 4.30e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.58  E-value: 4.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  456 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmyesegkvkqmqthflalKEHLTNEAATGSHRiIEELREQ 535
Cdd:PRK02224   255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE------------------RDDLLAEAGLDDAD-AEAVEAR 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  536 LKDLKGKYEGASAEVGKLRSQI----KQSEMLVGEFKRDEGR---LVEENKRLQKECGTCEVELERRGRRVVELEGQLKE 608
Cdd:PRK02224   316 REELEDRDEELRDRLEECRVAAqahnEEAESLREDADDLEERaeeLREEAAELESELEEAREAVEDRREEIEELEEEIEE 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  609 LGAKLA-LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVR----AQHIRPEEHEQLRSRLEQ 683
Cdd:PRK02224   396 LRERFGdAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRE 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  684 KSGELGKKVSELTLKNQTLQKDVEKLHADNKL------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 757
Cdd:PRK02224   476 RVEELEAELEDLEEEVEEVEERLERAEDLVEAedrierLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEE 555

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  758 ATQRYTEKKQEAERLLAE----NDKLTKNVSRLEAVfvapekheKELMGLKSNIAELKKQLSELNKK---CGEGQEKIRA 830
Cdd:PRK02224   556 KREAAAEAEEEAEEAREEvaelNSKLAELKERIESL--------ERIRTLLAAIADAEDEIERLREKreaLAELNDERRE 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  831 LMSENSSLKKTLSSQYVPAKTHE--EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEvlrrNLENVQNQMKAd 908
Cdd:PRK02224   628 RLAEKRERKRELEAEFDEARIEEarEDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELE----ELEELRERREA- 702

                          490       500       510
                   ....*....|....*....|....*....|....
gi 1720432849  909 yvsLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 942
Cdd:PRK02224   703 ---LENRVEALEALYDEAEELESMYGDLRAELRQ 733
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 137-239 4.32e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 4.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  137 IQLLCDHGASVNAKDID-GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTL 215
Cdd:PHA02878   150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                           90       100
                   ....*....|....*....|....*...
gi 1720432849  216 LDALG----HDSSYYARigdNLDILNLL 239
Cdd:PHA02878   230 RDKCGntplHISVGYCK---DYDILKLL 254
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 477-919 4.94e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.33  E-value: 4.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  477 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHltNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSq 556
Cdd:pfam01576  107 DLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQ--NSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKN- 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  557 ikQSEMLVGEFkrdEGRLVEENK---RLQKECGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDI 633
Cdd:pfam01576  184 --KHEAMISDL---EERLKKEEKgrqELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLA------KKEEELQAALARL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  634 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH-------------------------EQLRSRLEQKSGEL 688
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQrrdlgeelealkteledtldttaaqQELRSKREQEVTEL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  689 GKKVSELTLKNQTLQKDVEKLHAD----------------------NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDV 746
Cdd:pfam01576  333 KKALEEETRSHEAQLQEMRQKHTQaleelteqleqakrnkanlekaKQALESENAELQAELRTLQQAKQDSEHKRKKLEG 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  747 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 826
Cdd:pfam01576  413 QLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLESQLQDTQELLQEETRQKLNLST 489

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  827 KIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 906
Cdd:pfam01576  490 RLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLE 562

                          490
                   ....*....|....*.
gi 1720432849  907 ---ADYVSLEEHSRRM 919
Cdd:pfam01576  563 ekaAAYDKLEKTKNRL 578
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 410-906 6.14e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.79  E-value: 6.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  410 RSMLRPLELSLPSQTSYSE-NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA 488
Cdd:TIGR04523  193 KNKLLKLELLLSNLKKKIQkNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEK 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  489 LKDVQKrmyeSEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEgasaevgKLRSQIKQSEMLVGEFK 568
Cdd:TIGR04523  273 QKELEQ----NNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLE-------EIQNQISQNNKIISQLN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  569 RDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYE 648
Cdd:TIGR04523  342 EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI------KNLESQINDLESKIQNQEKLNQQKDEQIK 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  649 SAQGEIRQLKRDLESVRAQHIrpeEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMK 728
Cdd:TIGR04523  416 KLQQEKELLEKEIERLKETII---KNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELK 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  729 TRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRY----TEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLK 804
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIekleSEKKEKESKISDLEDELNKDDFELKK-----ENLEKEIDEKN 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  805 SNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaktheevkASLNSTVEKTNRALLEAKKRFDDTSQEV 884
Cdd:TIGR04523  568 KEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEI--------------EEKEKKISSLEKELEKAKKENEKLSSII 633

                          490       500
                   ....*....|....*....|..
gi 1720432849  885 SKLRDENEVLRRNLENVQNQMK 906
Cdd:TIGR04523  634 KNIKSKKNKLKQEVKQIKETIK 655
PRK01156 PRK01156
chromosome segregation protein; Provisional
 285-881 6.37e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 51.06  E-value: 6.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  285 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADD---LESEREKLKSLLAAKEKQHEEslrtIEALKN 361
Cdd:PRK01156   205 QIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMknrYESEIKTAESDLSMELEKNNY----YKELEE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  362 RFKYFESDhpgPGSYPSNRKEDMLHKQGQMYTTEPQCASPGIPPHMHSRSMLRPLELslpsQTSYSENEILKKELETLRT 441
Cdd:PRK01156   281 RHMKIIND---PVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVL----QKDYNDYIKKKSRYDDLNN 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  442 YYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA----------LKDVQKRMYESEGKVKQMQTHFL 511
Cdd:PRK01156   354 QILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQeidpdaikkeLNEINVKLQDISSKVSSLNQRIR 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  512 ALKEHLtneaatgshriiEELREQLKDLKGKyegASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVE 591
Cdd:PRK01156   434 ALRENL------------DELSRNMEMLNGQ---SVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEK 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  592 LERRGRRVVELEGQLKElgaklALSVPTEKFESMKSSLSnDINEKVKRLAEVGRDYESAQGEIRQLK-RDLESVRAQH-- 668
Cdd:PRK01156   499 IVDLKKRKEYLESEEIN-----KSINEYNKIESARADLE-DIKIKINELKDKHDKYEEIKNRYKSLKlEDLDSKRTSWln 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  669 ----IRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSh 744
Cdd:PRK01156   573 alavISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGK- 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  745 dvnVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCgEG 824
Cdd:PRK01156   652 ---IDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETL-ES 727

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849  825 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNStveKTNRALLEAKKRFDDTS 881
Cdd:PRK01156   728 MKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTS---LTRKYLFEFNLDFDDID 781
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 825-1351 8.58e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 50.35  E-value: 8.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  825 QEKIRALMSENSSLKKTLSSQYVPAKTHE----EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLEN 900
Cdd:TIGR00618  151 QGEFAQFLKAKSKEKKELLMNLFPLDQYTqlalMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKH 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  901 VQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAiladhRQGQEEIVSLHAEIKAQKKELDtiQECIKLKYAP-LARLE 979
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQL-----RARIEELRAQEAVLEETQERIN--RARKAAPLAAhIKAVT 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  980 ECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADE----- 1054
Cdd:TIGR00618  304 QIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTqhiht 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1055 LSKQLKDLSQKYSDVKSEREKLVEEKAKQASEiLAAQNLLQKQPVPLEQVEALkkslngtieqlkeelrskqrclerEQQ 1134
Cdd:TIGR00618  384 LQQQKTTLTQKLQSLCKELDILQREQATIDTR-TSAFRDLQGQLAHAKKQQEL------------------------QQR 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1135 TVSQLQQLLENQknssvtlAEHLKLKEALEKEvgiMKASLREKEEESQKK---TKEVSKLQTEVQTTKQALKNLETREVV 1211
Cdd:TIGR00618  439 YAELCAAAITCT-------AQCEKLEKIHLQE---SAQSLKEREQQLQTKeqiHLQETRKKAVVLARLLELQEEPCPLCG 508

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1212 DMSKYKATKNDLETQISNLNDKLASLNR-KYDQACEEKVSAKDEKELLHLsieQEIRDQKERCDKSLTTIMELQQRIQES 1290
Cdd:TIGR00618  509 SCIHPNPARQDIDNPGPLTRRMQRGEQTyAQLETSEEDVYHQLTSERKQR---ASLKEQMQEIQQSFSILTQCDNRSKED 585

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849 1291 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1351
Cdd:TIGR00618  586 IPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLT 646
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
472-683 9.25e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.40  E-value: 9.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  472 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEHL---TNEAATGSHRIIEELREQLKDLKGKYEGASA 548
Cdd:COG3206    167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNGlvdLSEEAKLLLQQLSELESQLAEARAELAEAEA 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  549 EVGKLRSQIKQSEMLVGEFKRDEG--RLVEENKRLQKEcgtcEVELERRGR----RVVELEGQLKELGAKLA-------- 614
Cdd:COG3206    241 RLAALRAQLGSGPDALPELLQSPViqQLRAQLAELEAE----LAELSARYTpnhpDVIALRAQIAALRAQLQqeaqrila 316

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  615 -LSVPTEKFESMKSSLSNDINEKVKRLAEVGRdyesAQGEIRQLKRDLESVRAQhirpeeHEQLRSRLEQ 683
Cdd:COG3206    317 sLEAELEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREVEVAREL------YESLLQRLEE 376
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1130-1376 1.75e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1130 EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1209
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-------LAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1210 vvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE-KVSAKDEKELLHLS--IEQEIRDQKERCDKSLTTIMELQQR 1286
Cdd:COG4942     93 -------AELRAELEAQKEELAELLRALYRLGRQPPLAlLLSPEDFLDAVRRLqyLKYLAPARREQAEELRADLAELAAL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1287 IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRT 1366
Cdd:COG4942    166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245

                          250
                   ....*....|
gi 1720432849 1367 HLLSAAQGHM 1376
Cdd:COG4942    246 AGFAALKGKL 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1051-1278 1.87e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1130
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ--------------LAALERRIAALARRIRALEQELAALEAELA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1131 REQQTVSQLQQLLENQKN-------SSVTLAEHLKLKEALE----KEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1199
Cdd:COG4942     87 ELEKEIAELRAELEAQKEelaellrALYRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849 1200 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLT 1278
Cdd:COG4942    167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK12704 PRK12704
phosphodiesterase; Provisional
 1060-1216 2.01e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.01  E-value: 2.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1060 KDLSQKYSDVKSEREKLVEEKAKQASE-----ILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQ 1134
Cdd:PRK12704    27 KIAEAKIKEAEEEAKRILEEAKKEAEAikkeaLLEAKEEIHKL---RNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1135 TVSQLQQLLENQKNSSvtlaehlklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEvQTTKQALKNLETREVVDMS 1214
Cdd:PRK12704   104 LLEKREEELEKKEKEL----------EQKQQELEKKEEELEELIEEQLQELERISGLTAE-EAKEILLEKVEEEARHEAA 172


                   ..
gi 1720432849 1215 KY 1216
Cdd:PRK12704   173 VL 174
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 521-730 2.50e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  521 AATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVV 600
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  601 ELEGQLKELGAKLALSVPTEKFESMKSSL-----SNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPE--- 672
Cdd:COG4942     94 ELRAELEAQKEELAELLRALYRLGRQPPLalllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEaer 173

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432849  673 --------EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTR 730
Cdd:COG4942    174 aeleallaELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 960-1350 2.57e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 48.14  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  960 ELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK-------KGKQENERLRADLAALQKELQ 1032
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAgltrrlsAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1033 DRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN 1112
Cdd:pfam19220  101 EAEAAKEELRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQ 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1113 GTIEQLKEELRSKQRCL-EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMK---ASLREKEEESQKKTKEV 1188
Cdd:pfam19220  181 ALSEEQAAELAELTRRLaELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRaerASLRMKLEALTARAAAT 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1189 SKLQTEVQTtkqalknletrevvdmskykatkndletqisNLNDKLASLnRKYDQACEEKVSAKDEKELLHLSIEQEIRD 1268
Cdd:pfam19220  261 EQLLAEARN-------------------------------QLRDRDEAI-RAAERRLKEASIERDTLERRLAGLEADLER 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1269 QKERCDKSLTTIMELQQRIQESAKQIEAKDNKitellndverLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQ 1348
Cdd:pfam19220  309 RTQQFQEMQRARAELEERAEMLTKALAAKDAA----------LERAEERIASLSDRIAELTKRFEVERAALEQANRRLKE 378


                   ..
gi 1720432849 1349 QL 1350
Cdd:pfam19220  379 EL 380
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1051-1256 2.76e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRcle 1130
Cdd:COG3883     24 ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKL---QAEIAEAEAEIEERREELGERARALYR--- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1131 rEQQTVSQLQQLLENQKNSSVtlaehlklkealekevgIMKASLREKEEESQKKT-KEVSKLQTEVQTTKQALKNLETRE 1209
Cdd:COG3883     98 -SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADLlEELKADKAELEAKKAELEAKLAEL 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1720432849 1210 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKE 1256
Cdd:COG3883    160 EALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-220 2.96e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 2.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   92 LHLAAKYGHALCLQKLLQYNcpteHVDLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDI----------DGRT 156
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849  157 PLVLATQMCRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLVKNGADLTLLDALG 220
Cdd:cd22192     92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
868-1366 2.98e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.76  E-value: 2.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  868 RALLEAKKRFDDTSQEVSKLRDENEVLRRnLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQEANAAILADHRQ 942
Cdd:COG4913    228 DALVEHFDDLERAHEALEDAREQIELLEP-IRELAERYAAARERLAELEYLRAALrlwfaQRRLELLEAELEELRAELAR 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  943 GQEEIVSLHAEIKAQKKELDTIQEciKLKYAPLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1022
Cdd:COG4913    307 LEAELERLEARLDALREELDELEA--QIRGNGGDRLEQLEREIER----LERELEERERRRARLEALLAALGLPLPASAE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1023 DLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQ---PV 1099
Cdd:COG4913    381 EFAALRAEAAAL-----------------LEALEEELEALEEALAEAEAALRDLRRELRELEAEI---ASLERRKsniPA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1100 PLEQV-EALKKSLNGTIEQLK---E--ELRSKQ-----------------------------RCLEREQQT-------VS 1137
Cdd:COG4913    441 RLLALrDALAEALGLDEAELPfvgEliEVRPEEerwrgaiervlggfaltllvppehyaaalRWVNRLHLRgrlvyerVR 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1138 QLQQLLENQKNSSVTLAEHLKLKE-----ALEKEVG--------------------IMKASLREKEEESQKKTKEVSKLQ 1192
Cdd:COG4913    521 TGLPDPERPRLDPDSLAGKLDFKPhpfraWLEAELGrrfdyvcvdspeelrrhpraITRAGQVKGNGTRHEKDDRRRIRS 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1193 TEV--QTTKQALKNLETRevvdMSKYKATKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIR--- 1267
Cdd:COG4913    601 RYVlgFDNRAKLAALEAE----LAELEEELAEAEERLEALEAELDALQERREAL--QRLAEYSWDEIDVASAEREIAele 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1268 DQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQ 1347
Cdd:COG4913    675 AELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE-------LDELQDRLEAAEDLARLEL 747

                          570
                   ....*....|....*....
gi 1720432849 1348 QQLADADRQHQEVIAIYRT 1366
Cdd:COG4913    748 RALLEERFAAALGDAVERE 766
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-85 3.08e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 3.08e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849   25 LMKAAERGDVEKVSSILAKKGVhpgKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRD 85
Cdd:pfam12796   34 LHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
46 PHA02562
endonuclease subunit; Provisional
 705-969 3.68e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.09  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  705 DVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQR----YTEKKQEAERLLAENDKLT 780
Cdd:PHA02562   161 DISVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARkqnkYDELVEEAKTIKAEIEELT 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  781 knvSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgegqekirALMSENSSLKKTLSSQYvpaKTHEEVKASLN 860
Cdd:PHA02562   241 ---DELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKV---------IKMYEKGGVCPTCTQQI---SEGPDRITKIK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  861 STVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLrRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADH 940
Cdd:PHA02562   306 DKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKL-LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKL 384

                          250       260
                   ....*....|....*....|....*....
gi 1720432849  941 RQGQEEIVSLHAEIKAQKKELDTIQECIK 969
Cdd:PHA02562   385 QDELDKIVKTKSELVKEKYHRGIVTDLLK 413
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 772-1034 4.55e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 4.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  772 LLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpakt 851
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------------- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  852 heevkasLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevLRRNLENVQNQMKADYVSL---EEHSRRMSTVSQSLKE 928
Cdd:COG4942     74 -------LEQELAALEAELAELEKEIAELRAELEAQKEE---LAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKY 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  929 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIqeciklkyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDE 1008
Cdd:COG4942    144 LAPARREQAEELRADLAELAALRAELEAERAELEAL----------LAELEEERAALEALKAERQKLLARLEKELAELAA 213

                          250       260
                   ....*....|....*....|....*.
gi 1720432849 1009 EVKKGKQENERLRADLAALQKELQDR 1034
Cdd:COG4942    214 ELAELQQEAEELEALIARLEAEAAAA 239
COG5022 COG5022
Myosin heavy chain [General function prediction only];
945-1316 5.15e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.15  E-value: 5.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  945 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGkqenerlradl 1024
Cdd:COG5022    817 ACIIKLQKTIKREKKLRETEEVEFSLKAEVL--IQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQ----------- 883

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1025 aalQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEqv 1104
Cdd:COG5022    884 ---LQELKIDVKSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNK-- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1105 ealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkASLREKEEESQKK 1184
Cdd:COG5022    959 ------LHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEST----KQLKELPVEVAEL 1028

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1185 TKEVSKLQTEvQTTKQALKNLETREVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIE 1263
Cdd:COG5022   1029 QSASKIISSE-STELSILKPLQKLKGLLLLENNQLqARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN 1107

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1264 QEIRDQKERCDKSLTTIMELQQRIQESAKQ----IEAKDNKITELLNDVERLKQALN 1316
Cdd:COG5022   1108 LVKPANVLQFIVAQMIKLNLLQEISKFLSQlvntLEPVFQKLSVLQLELDGLFWEAN 1164
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 483-1365 5.88e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 5.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  483 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEvgkLRSQIKQSEM 562
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  563 LVGEFKrdeGRLVEENKRLQKECGTCEVELERRG---RRVVELEGQLKELGAKLALS-VPTEKFESMKSSLSNDInEKVK 638
Cdd:pfam01576  230 QIAELR---AQLAKKEEELQAALARLEEETAQKNnalKKIRELEAQISELQEDLESErAARNKAEKQRRDLGEEL-EALK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  639 RLAEVGRDYESAQGEIR--------QLKRDLESVRAQHirPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 710
Cdd:pfam01576  306 TELEDTLDTTAAQQELRskreqevtELKKALEEETRSH--EAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  711 ADNKllnqqvhSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVF 790
Cdd:pfam01576  384 SENA-------ELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKN 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  791 VapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRAL 870
Cdd:pfam01576  457 I---KLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQL 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  871 LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK---ADYVSLEEHSRRMSTVSQSLKEAQEANAAILA--------- 938
Cdd:pfam01576  527 SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEekaAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSnlekkqkkf 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  939 DHRQGQEEIVSLH-------AEIKAQKKELDTIQECIKLKYAPLARlEECERKFKATEKGLKEQLSEQ--THKCRQRDEE 1009
Cdd:pfam01576  607 DQMLAEEKAISARyaeerdrAEAEAREKETRALSLARALEEALEAK-EELERTNKQLRAEMEDLVSSKddVGKNVHELER 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1010 VKKG-KQENERLRADLAALQKELQD---------------RNALAEEAREAERALSGKADELSKQLKDLsqkysdvkser 1073
Cdd:pfam01576  686 SKRAlEQQVEEMKTQLEELEDELQAtedaklrlevnmqalKAQFERDLQARDEQGEEKRRQLVKQVREL----------- 754

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1074 EKLVEEKAKQASEILAAQNLLQKQPVPLE-QVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQ-LQQLLENQKN 1148
Cdd:pfam01576  755 EAELEDERKQRAQAVAAKKKLELDLKELEaQIDAANKGREEAVKQLKKlqaQMKDLQRELEEARASRDEiLAQSKESEKK 834

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1149 SSVTLAEHLKLKEALekevgimKASLREKEEESQkktkEVSKLQTEVQ---TTKQALKNLETREVVDMSKYKATKNDLET 1225
Cdd:pfam01576  835 LKNLEAELLQLQEDL-------AASERARRQAQQ----ERDELADEIAsgaSGKSALQDEKRRLEARIAQLEEELEEEQS 903

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1226 QISNLNDKLASLNRKYDQ-----ACEEKVSAKDEKELLHLsiEQEIRDQKERCD--------KSLTTIMELQQRIQESAK 1292
Cdd:pfam01576  904 NTELLNDRLRKSTLQVEQlttelAAERSTSQKSESARQQL--ERQNKELKAKLQemegtvksKFKSSIAALEAKIAQLEE 981

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720432849 1293 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYR 1365
Cdd:pfam01576  982 QLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARR 1054
Ank_4 pfam13637
Ankyrin repeats (many copies);
88-140 7.71e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 7.71e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720432849   88 GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL 140
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
40-95 9.68e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 9.68e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432849   40 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 95
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 626-1033 9.87e-05

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 46.98  E-value: 9.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  626 KSSLSNDI-----NEKVKRLAEVGRDYESAQGE-IRQLKRDL--ESVRAQ-HIRP-----EEHEQLRSRLEQKSGELGKK 691
Cdd:pfam13166   29 KTTLSRLLrslelGEPHPKFANGKFEWTNGQPLdIRVFNRDFveENLSEQgEIKPiftlgEESIEIQEKIAKLKKEIKDH 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  692 VSELTLKNQTLQ---KDVEKLHAD-NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVnvEDLNKKLSEATQRYTEKKQ 767
Cdd:pfam13166  109 EEKLDAAEANLQkldKEKEKLEADfLDECWKKIKRKKNSALSEALNGFKYEANFKSRLL--REIEKDNFNAGVLLSDEDR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  768 EA------ERLLAENDKLTKNVSRLEAVFVAPEKHEKeLMGLKSNIAELKKQLSeLNKKCGEGQEKIRALMSE------- 834
Cdd:pfam13166  187 KAalatvfSDNKPEIAPLTFNVIDFDALEKAEILIQK-VIGKSSAIEELIKNPD-LADWVEQGLELHKAHLDTcpfcgqp 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  835 -NSSLKKTLSSQYvpAKTHEEVKASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMKADYV 910
Cdd:pfam13166  265 lPAERKAALEAHF--DDEFTEFQNRLQKLIEKVESAISSLLAQLPavsDLASLLSAFELDVEDIESEAEVLNSQLDGLRR 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  911 SLEEHSRRMSTVSQ---------SLKEAQEANAAILADHrqgqEEIVSLHAEIKAQKK---ELDTIQECiklkYAPLARL 978
Cdd:pfam13166  343 ALEAKRKDPFKSIEldsvdakieSINDLVASINELIAKH----NEITDNFEEEKNKAKkklRLHLVEEF----KSEIDEY 414

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720432849  979 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKkgkqenerlradlaALQKELQD 1033
Cdd:pfam13166  415 KDKYAGLEKAINSLEKEIKNLEAEIKKLREEIK--------------ELEAQLRD 455
Ank_5 pfam13857
Ankyrin repeats (many copies);
173-220 1.14e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720432849  173 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALG 220
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1085-1237 1.34e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1085 SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSsvtLAEHLKLKE--A 1162
Cdd:COG1579     17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---LGNVRNNKEyeA 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720432849 1163 LEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASL 1237
Cdd:COG1579     94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 752-1187 1.37e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.69  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  752 NKKLSEATQRYTEKKQ-EAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKira 830
Cdd:pfam18971  412 NTKLDNLSEKEKEKFQnEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGKKADKALDR--- 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  831 lmSENSSLKKTLSSQ---YVPAKTHEEVKASLNST--VEKTNR-ALLEAKkrFDDTSqeVSKLRDENEV-----LRRNLE 899
Cdd:pfam18971  489 --EKNVTLQGSLKHDgvmFVDYSNFKYTNASKNPNkgVGATNGvSHLEAG--FNKVA--VFNLPDLNNLaitsfVRRNLE 562

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  900 NvqnQMKADYVSLEEHSRRMSTVSQSLKEAqeANAAILADHRQGQEEIVSLHAEIKAQKKELD-TIQECIKLKyaplarl 978
Cdd:pfam18971  563 N---KLTAKGLSLQEANKLIKDFLSSNKEL--AGKALNFNKAVAEAKSTGNYDEVKKAQKDLEkSLRKREHLE------- 630

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  979 EECERKFKaTEKGLKEQLSEQTHKCRQRDEEVKK-GKQENERLRA-----DLAALQKELQDrnalaeeareaeralsgKA 1052
Cdd:pfam18971  631 KEVEKKLE-SKSGNKNKMEAKAQANSQKDEIFALiNKEANRDARAiaytqNLKGIKRELSD-----------------KL 692

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1053 DELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN----------GTIEQLKEEL 1122
Cdd:pfam18971  693 EKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNefkngknkdfSKVTQAKSDL 772

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720432849 1123 RSKQRCLEREQQTVSQLQQLlenqkNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKE 1187
Cdd:pfam18971  773 ENSVKDVIINQKVTDKVDNL-----NQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNED 832
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 290-1206 1.49e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.58  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  290 EIENEDLREKLRKIQQEQRILLdkvnglqlQLNEEVMVADDLESEREKLKSLLAAKEKQ----HEESLRTIEALKNRfky 365
Cdd:TIGR00606  244 ENELDPLKNRLKEIEHNLSKIM--------KLDNEIKALKSRKKQMEKDNSELELKMEKvfqgTDEQLNDLYHNHQR--- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  366 fESDHPGPGSYPSNRKEDMLHKQGQMYTTE----------PQCASPGIPPHMHSRSMLRpLELSLPSQTSYSENE-ILKK 434
Cdd:TIGR00606  313 -TVREKERELVDCQRELEKLNKERRLLNQEktellveqgrLQLQADRHQEHIRARDSLI-QSLATRLELDGFERGpFSER 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  435 ELETLRTYYDSAKQDRLKFQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 514
Cdd:TIGR00606  391 QIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVI 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  515 EHLTNeAATGSHRIIE---ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLvgEFKRDEGRLVEENKRLQKEcGTCEVE 591
Cdd:TIGR00606  461 KELQQ-LEGSSDRILEldqELRKAERELSKAEKNSLTETLKKEVKSLQNEKA--DLDRKLRKLDQEMEQLNHH-TTTRTQ 536

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  592 LERRGRRVVELEGQLK--------ELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLES 663
Cdd:TIGR00606  537 MEMLTKDKMDKDEQIRkiksrhsdELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES 616

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  664 VRAQHIRPEEHEQLRSRLEQKSGELGKKVSELtlknQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 743
Cdd:TIGR00606  617 KEEQLSSYEDKLFDVCGSQDEESDLERLKEEI----EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 692

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  744 HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGE 823
Cdd:TIGR00606  693 LQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DLKEKEIPELRNKLQKVNRDIQRLKNDIEE 769

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  824 GQEKIRALMSENSSLKKTLSSQYVPAKTHEEVK------ASLNSTVEKTN--RALLEAKKRFDDTSQEVSKLRDENEVLR 895
Cdd:TIGR00606  770 QETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiAQQAAKLQGSDldRTVQQVNQEKQEKQHELDTVVSKIELNR 849

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  896 RNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQeanaailadhrQGQEEIVSLHAEIKAQKKEldtiqecIKLKYAPL 975
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQLVELSTEVQSLIRE-------IKDAKEQD 911

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  976 ARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnalaeEAREAERALSGKADEL 1055
Cdd:TIGR00606  912 SPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDD-----YLKQKETELNTVNAQL 986

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1056 SKQLKDLSQKYSDVKSEREKLveEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKeelrskqrcLEREQQT 1135
Cdd:TIGR00606  987 EECEKHQEKINEDMRLMRQDI--DTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQ---------VLQMKQE 1055

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849 1136 VSQLQQLLENQKNSSVTLAEHLKlkeALEKEVGIMKASLREKeeESQKKTKEVSKLQTEVQTTKQALKNLE 1206
Cdd:TIGR00606 1056 HQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEKYREMMIVMRTTELVNKDLD 1121
Ank_4 pfam13637
Ankyrin repeats (many copies);
21-71 1.56e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720432849   21 YDDRLMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECL 71
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVL 50
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 890-1280 1.85e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  890 ENEVLRRNLENVQNQMKADYVSLEEHSRRMStvSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK 969
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKAVSERQQQEKFEKME--QERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAM 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  970 LKYAPLARLEECERKfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAAlqkelqdrnalaeeareaerals 1049
Cdd:pfam17380  345 ERERELERIRQEERK-RELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEA----------------------- 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1050 gkadelskqlkdlSQKYSDVKSEREKLVEEKAKQASEILAAQ-NLLQKQPVPLEQvealkkslngtiEQLKEELRSKQRC 1128
Cdd:pfam17380  401 -------------ARKVKILEEERQRKIQQQKVEMEQIRAEQeEARQREVRRLEE------------ERAREMERVRLEE 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 LEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETR 1208
Cdd:pfam17380  456 QERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERR 535

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720432849 1209 EVVDMSKYKATKNDLETQISNlNDKLASLNRKYDQACEEkvsakdEKELLHLSIEQEIRDQKERCDKSLTTI 1280
Cdd:pfam17380  536 REAEEERRKQQEMEERRRIQE-QMRKATEERSRLEAMER------EREMMRQIVESEKARAEYEATTPITTI 600
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 792-1033 1.95e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.69  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  792 APEKHEK-ELMGLKSNIAELKKQLSELN------KKCGEGQEKIRALMSENSSLKKTLS--SQYVPA-----KTHEEVK- 856
Cdd:PRK05771     2 APVRMKKvLIVTLKSYKDEVLEALHELGvvhiedLKEELSNERLRKLRSLLTKLSEALDklRSYLPKlnplrEEKKKVSv 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  857 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY-VSLEEHSRRMSTVSQSLKEAQEANAa 935
Cdd:PRK05771    82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLdLSLLLGFKYVSVFVGTVPEDKLEEL- 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  936 iladhrqgQEEIVSLHAEIKAQKKELDTI-----QECIKLKYAPLARLEEceRKFKATEKGLkeqLSEQTHKCRQRDEEV 1010
Cdd:PRK05771   161 --------KLESDVENVEYISTDKGYVYVvvvvlKELSDEVEEELKKLGF--ERLELEEEGT---PSELIREIKEELEEI 227

                          250       260
                   ....*....|....*....|...
gi 1720432849 1011 KKgkqENERLRADLAALQKELQD 1033
Cdd:PRK05771   228 EK---ERESLLEELKELAKKYLE 247
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 912-1152 1.99e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  912 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEeceRKFKATEKG 991
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR---AELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  992 LKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREaeralsgKADELSKQLKDLSQKYSDVKS 1071
Cdd:COG4942    106 LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRA-------DLAELAALRAELEAERAELEA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1072 EREKLVEEKAKQASEILAAQNLLQKqpvpleqvealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1151
Cdd:COG4942    179 LLAELEEERAALEALKAERQKLLAR--------------LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                   .
gi 1720432849 1152 T 1152
Cdd:COG4942    245 A 245
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 750-1256 2.02e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  750 DLNKKLSEATQRYTEKKQEAerlLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcGEGQEKIR 829
Cdd:COG5185    111 NYEWSADILISLLYLYKSEI---VALKDELIKVEKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKK-LEIFGLTL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  830 ALMSENSSLKKTLSSQYVPAK----THEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQM 905
Cdd:COG5185    187 GLLKGISELKKAEPSGTVNSIkeseTGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLR 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  906 KADYVSLEEHSRRMStvsqslkeaqEANAAILADHRQGQEEIVSLHAEIKAQKKeldtiQECIKLKYAPLARLEECERKF 985
Cdd:COG5185    267 LEKLGENAESSKRLN----------ENANNLIKQFENTKEKIAEYTKSIDIKKA-----TESLEEQLAAAEAEQELEESK 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  986 KATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRAdlaalqkelqdrnalaeeareaeralsgkadelSKQLKDLSQK 1065
Cdd:COG5185    332 RETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVG---------------------------------EVELSKSSEE 378

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1066 YSDVKSEREKLVEEkakqasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclEREQQTVSQLQQLLEN 1145
Cdd:COG5185    379 LDSFKDTIESTKES------LDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQA----TSSNEEVSKLLNELIS 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1146 QKNSSVTLAEHLKLKEALEKEVGIMkaslREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVdmsKYKATKNDLET 1225
Cdd:COG5185    449 ELNKVMREADEESQSRLEEAYDEIN----RSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLER---QLEGVRSKLDQ 521

                          490       500       510
                   ....*....|....*....|....*....|.
gi 1720432849 1226 QISNLNDKLASLNRKYDQACEEKVSAKDEKE 1256
Cdd:COG5185    522 VAESLKDFMRARGYAHILALENLIPASELIQ 552
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
504-723 2.03e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  504 KQMQTHFLALKEHLTNeaATGSHRIIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEE 577
Cdd:COG4913    221 PDTFEAADALVEHFDD--LERAHEALEDAREQIELLEPirelaeRYAAARERLAELEYLRAALRLWFAQRRLELLEAELE 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  578 N-----KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQG 652
Cdd:COG4913    299 ElraelARLEAELERLEARLDALREELDELEAQIRGNGGDR------------LEQLEREIERLERELEERERRRARLEA 366

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849  653 EIRQLK-------RDLESVRAQ-HIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSL 723
Cdd:COG4913    367 LLAALGlplpasaEEFAALRAEaAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAL 445
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-185 2.06e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720432849  153 DGRTPLVLATQMC-RPTICQLLIDRGADVNSRDK 185
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 104-247 2.09e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 2.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  104 LQKLLQY--NCPTEHVDlQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGAD-- 179
Cdd:PHA02874    17 IEKIIKNkgNCINISVD-ETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDts 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  180 ---------------------VNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNL 238
Cdd:PHA02874    96 ilpipciekdmiktildcgidVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175

                          170
                   ....*....|.
gi 1720432849  239 L--KTASENTN 247
Cdd:PHA02874   176 LleKGAYANVK 186
Ank_5 pfam13857
Ankyrin repeats (many copies);
74-126 2.35e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 2.35e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720432849   74 ILTHG-IDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALH 126
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-173 2.37e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   93 HLAAKyGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 172
Cdd:PTZ00322    88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   .
gi 1720432849  173 L 173
Cdd:PTZ00322   167 L 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
107-161 2.74e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 2.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432849  107 LLQY-NCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLA 161
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 444-1032 2.77e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.48  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  444 DSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmYESEGKVKQMQTHFLALKEHLTNEAAT 523
Cdd:pfam05483  179 EETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEE-YKKEINDKEKQVSLLLIQITEKENKMK 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  524 GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECgtcEVELERRGRRVVELE 603
Cdd:pfam05483  258 DLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL---QIATKTICQLTEEKE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  604 GQLKELG-AKLALSVPTEKFESMKSSLSNDINEKVKRLaevgrdyESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLE 682
Cdd:pfam05483  335 AQMEELNkAKAAHSFVVTEFEATTCSLEELLRTEQQRL-------EKNEDQLKIITMELQKKSSEL---EEMTKFKNNKE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  683 QKSGELGKKVSE---LTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEAT 759
Cdd:pfam05483  405 VELEELKKILAEdekLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  760 QRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLK 839
Cdd:pfam05483  485 LKNIELTAHCDKLLLENKELTQEASDMTL----------ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVR 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  840 KTLSSQyvpaktHEEVKASLNSTVEKTNRALLEA-----------------KKRFDDTSQEVSKLRDENEVLRRNLENVQ 902
Cdd:pfam05483  555 EEFIQK------GDEVKCKLDKSEENARSIEYEVlkkekqmkilenkcnnlKKQIENKNKNIEELHQENKALKKKGSAEN 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  903 NQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKL----KYAPLARL 978
Cdd:pfam05483  629 KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKrcqhKIAEMVAL 708

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849  979 EECERkfKATEKGLKEQLSE-QTHKCRQRDEEVKKGKQENE--RLRADLAALQKELQ 1032
Cdd:pfam05483  709 MEKHK--HQYDKIIEERDSElGLYKNKEQEQSSAKAALEIElsNIKAELLSLKKQLE 763
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 945-1334 2.88e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.35  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  945 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1024
Cdd:pfam02463  160 EEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERI 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1025 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQV 1104
Cdd:pfam02463  240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSE--------------LLKL 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1105 EALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimKASLREKEEESQKK 1184
Cdd:pfam02463  306 ERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEK----LEQLEEELLAKKKL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1185 TKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQ 1264
Cdd:pfam02463  382 ESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL 461

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1265 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQ 1334
Cdd:pfam02463  462 KDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRL 531
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 171-239 2.93e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 2.93e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 239
Cdd:PTZ00322    99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 665-1210 3.44e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 3.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  665 RAQHIRPEEH-EQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 743
Cdd:pfam05557    1 RAELIESKARlSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  744 HDVNVEDLNKKLSEATQRYTEKKqeaERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 823
Cdd:pfam05557   81 KKKYLEALNKKLNEKESQLADAR---EVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  824 GQEKIRALMSENSSLKK---TLSSQYVPAKTHEEVKASLNS--TVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL 898
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKElefEIQSQEQDSEIVKNSKSELARipELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  899 ENvQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARL 978
Cdd:pfam05557  238 ER-EEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARREL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  979 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEareaeralSGKADELSKQ 1058
Cdd:pfam05557  317 EQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNYSPQL--------LERIEEAEDM 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1059 LKDLSQKYSDVKSEREKLVEEKAKQAS---------EILAAQNLLQKQPVPLEQVEALKKSLNgTIEQLKEELRSKQRCL 1129
Cdd:pfam05557  389 TQKMQAHNEEMEAQLSVAEEELGGYKQqaqtlerelQALRQQESLADPSYSKEEVDSLRRKLE-TLELERQRLREQKNEL 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1130 EREQQTVSqLQQLLENQKNSSVTLAEHLKLK---------EALEKEVGIMKASLREKEEESQK-----------KTKEVS 1189
Cdd:pfam05557  468 EMELERRC-LQGDYDPKKTKVLHLSMNPAAEayqqrknqlEKLQAEIERLKRLLKKLEDDLEQvlrlpettstmNFKEVL 546

                          570       580
                   ....*....|....*....|.
gi 1720432849 1190 KLQTEVQTTKqaLKNLETREV 1210
Cdd:pfam05557  547 DLRKELESAE--LKNQRLKEV 565
mukB PRK04863
chromosome partition protein MukB;
434-1252 3.50e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.33  E-value: 3.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  434 KELETLRTYYDSAkqDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 513
Cdd:PRK04863   260 KHLITESTNYVAA--DYMRHANERRVHLEE----ALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAA 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  514 KEHLT----------------------NEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK--QSEMLVGEFK- 568
Cdd:PRK04863   334 SDHLNlvqtalrqqekieryqadleelEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLAdyQQALDVQQTRa 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  569 ---RDEGRLVEENKRLqkeCGTCEVELERRGRRVVELEGQLKELGAKLaLSVPTekfesmKSSLSNDINEK-------VK 638
Cdd:PRK04863   414 iqyQQAVQALERAKQL---CGLPDLTADNAEDWLEEFQAKEQEATEEL-LSLEQ------KLSVAQAAHSQfeqayqlVR 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  639 RLA-EVGRdyESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLeqksgelgkkvseltlknQTLQKDVEKLHADNKLLN 717
Cdd:PRK04863   484 KIAgEVSR--SEAWDVARELLRRLREQRHL---AEQLQQLRMRL------------------SELEQRLRQQQRAERLLA 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  718 Q--QVHSLTVEMKTRYvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKN----------VSR 785
Cdd:PRK04863   541 EfcKRLGKNLDDEDEL------EQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARapawlaaqdaLAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  786 LEAVFvaPEK----------------HEKELM----GLKSNIAELKKQLSELNKKCGEGQEKIRALMS-----------E 834
Cdd:PRK04863   615 LREQS--GEEfedsqdvteymqqlleRERELTverdELAARKQALDEEIERLSQPGGSEDPRLNALAErfggvllseiyD 692

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  835 NSSLKKT--LSSQYVPAKtHEEVKASLNSTVEKtnralLEAkkrFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSL 912
Cdd:PRK04863   693 DVSLEDApyFSALYGPAR-HAIVVPDLSDAAEQ-----LAG---LEDCPEDLYLIEGDPDSFDDSVFSVEELEKAVVVKI 763

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  913 EEHSRRMS---TVSQSLKEAQEANAAILadhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYA----------PLARLE 979
Cdd:PRK04863   764 ADRQWRYSrfpEVPLFGRAAREKRIEQL---RAEREELAERYATLSFDVQKLQRLHQAFSRFIGshlavafeadPEAELR 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  980 ECERKFKATEKGLkEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKE-LQDRnalaeeareaeralsgkADELSKQ 1058
Cdd:PRK04863   841 QLNRRRVELERAL-ADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADEtLADR-----------------VEEIREQ 902

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1059 LKDLSQKYSDVKSEreklveekAKQASEILAAQNLLQKQPvplEQVEALKKSLngtiEQLKEELR-SKQRCL-------E 1130
Cdd:PRK04863   903 LDEAEEAKRFVQQH--------GNALAQLEPIVSVLQSDP---EQFEQLKQDY----QQAQQTQRdAKQQAFaltevvqR 967

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1131 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtREV 1210
Cdd:PRK04863   968 RAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRA---REQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELK-QEL 1043

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720432849 1211 VDM-----------------------SKYKATKNDLETQIS-------NLNDKLASLNRKYDQACEEKVSAK 1252
Cdd:PRK04863  1044 QDLgvpadsgaeerararrdelharlSANRSRRNQLEKQLTfceaemdNLTKKLRKLERDYHEMREQVVNAK 1115
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1015-1359 3.55e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1015 QENERLRADLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQnlL 1094
Cdd:COG4913    606 FDNRAKLAALEAELAELEEE-----------------LAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVAS--A 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1095 QKQpvpLEQVEALKKSL---NGTIEQLK---EELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLK--LKEALEKE 1166
Cdd:COG4913    667 ERE---IAELEAELERLdasSDDLAALEeqlEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQdrLEAAEDLA 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1167 VGIMKASLREK--EEESQKKTKEVSK-LQTEVQTTKQALKNLETREVVDMSKYKAT----KNDLETQISNLNDKLASLNR 1239
Cdd:COG4913    744 RLELRALLEERfaAALGDAVERELREnLEERIDALRARLNRAEEELERAMRAFNREwpaeTADLDADLESLPEYLALLDR 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1240 KYDQACEEKVsaKDEKELLHLSIEQEIRDqkercdkslttimeLQQRIQESAKQIEakdnkitellndvERLKQaLN-GL 1318
Cdd:COG4913    824 LEEDGLPEYE--ERFKELLNENSIEFVAD--------------LLSKLRRAIREIK-------------ERIDP-LNdSL 873

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1720432849 1319 SQLTYSSGS-----PTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1359
Cdd:COG4913    874 KRIPFGPGRylrleARPRPDPEVREFRQELRAVTSGASLFDEELSE 919
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 749-984 3.96e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 3.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  749 EDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekelmglksNIAELKKQLSELNKKCGEGQEKI 828
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER-----------------RIAALARRIRALEQELAALEAEL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  829 RALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNR----ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 904
Cdd:COG4942     86 AELEKEIAELRAELEAQ-------KEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRAD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  905 MKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK 984
Cdd:COG4942    159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 120-151 4.19e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 4.19e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720432849  120 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 151
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1004-1220 4.29e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1004 RQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQ 1083
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI----EERREELGERARA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1084 ASE----------ILAAQN---LLQKQPVpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSS 1150
Cdd:COG3883     95 LYRsggsvsyldvLLGSESfsdFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720432849 1151 VT-LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1220
Cdd:COG3883    174 EAqQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 244
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
432-836 4.65e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 4.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  432 LKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERvkEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFL 511
Cdd:COG4717     93 LQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQEL--EALEAELAELPERLEELEERLEELRELEEELEELEA 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  512 ALKEhLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEcgtceve 591
Cdd:COG4717    171 ELAE-LQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  592 lerrgRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH-IR 670
Cdd:COG4717    243 -----ERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEeLE 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  671 PEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSltvemktryvpLRVSEEMKKSHDVNVED 750
Cdd:COG4717    318 EEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELE-----------QEIAALLAEAGVEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  751 LNKKLsEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA 830
Cdd:COG4717    387 LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALD-EEELEEELEELEEELEELEEELEELREELAELEAELEQ 464


                   ....*.
gi 1720432849  831 LMSENS 836
Cdd:COG4717    465 LEEDGE 470
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 66-187 5.19e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 5.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   66 GNLECLNAILTHgiDVATRDSAGRNALHLAAKYGH-------ALCLQKLLQYNCPTEHVD-------LQGRTALHDAAMA 131
Cdd:cd21882      6 GLLECLRWYLTD--SAYQRGATGKTCLHKAALNLNdgvneaiMLLLEAAPDSGNPKELVNapctdefYQGQTALHIAIEN 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849  132 DCPSSIQLLCDHGASVNAKDID-------------GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQN 187
Cdd:cd21882     84 RNLNLVRLLVENGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEAQD 152
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
677-906 5.35e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 5.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  677 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKlhADNKLlnqqvhsltVEMKTRYVPLRVSEEMKkSHDVNVEDLNKKLS 756
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQLPELRKELEE--AEAAL---------EEFRQKNGLVDLSEEAK-LLLQQLSELESQLA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  757 EATQRYTEKKQEAERLlaeNDKLTKNVSRLEAVFVAPEkhekeLMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENS 836
Cdd:COG3206    230 EARAELAEAEARLAAL---RAQLGSGPDALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA 301

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720432849  837 SLKKTLSSQYVPAKTHEEVK-ASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMK 906
Cdd:COG3206    302 ALRAQLQQEAQRILASLEAElEALQAREASLQAQLAQLEARLAelpELEAELRRLEREVEVARELYESLLQRLE 375
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1057-1318 5.48e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 5.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1057 KQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL-EQVEALKKSLNgTIEQLKEELRSKQRCLEREQQT 1135
Cdd:PRK03918   175 KRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELrEELEKLEKEVK-ELEELKEEIEELEKELESLEGS 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1136 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkaslrekeEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmSK 1215
Cdd:PRK03918   254 KRKLEEKIRELEERIEELKKEIEELEEKVKEL-----------KELKEKAEEYIKLSEFYEEYLDELREIEKRL----SR 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1216 YKATKNDLETQISNLNDKLASLN--RKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSLT---------TIMELQ 1284
Cdd:PRK03918   319 LEEEINGIEERIKELEEKEERLEelKKKLKELEKRLEELEERHELYEEAKA-KKEELERLKKRLTgltpeklekELEELE 397

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1720432849 1285 QRIQESAKQIEAKDNKITELLNDVERLKQALNGL 1318
Cdd:PRK03918   398 KAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
473-688 5.66e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 5.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  473 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQmqthflalkehltneaatgshriIEELREQLKDLKGKYEGASAEVGK 552
Cdd:COG4717     64 RKPELNLKELKELEEELKEAEEKEEEYAELQEE-----------------------LEELEEELEELEAELEELREELEK 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  553 LRsQIKQSEMLVGEFKRDEGRLVEENKRLQkecgtcevELERRGRRVVELEGQLKELGAKLAlsvptEKFESMKSSLSND 632
Cdd:COG4717    121 LE-KLLQLLPLYQELEALEAELAELPERLE--------ELEERLEELRELEEELEELEAELA-----ELQEELEELLEQL 186

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432849  633 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGEL 688
Cdd:COG4717    187 SLATEEELQDLAEELEELQQRLAELEEELEEAQ------EELEELEEELEQLENEL 236
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 456-1143 6.08e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.44  E-value: 6.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  456 ELAHKVAECKALA-LECERVKEDSDEQ-IKQLEDALKdvqkRMYESEGKVKQMQThflaLKEHLTNEAATGSHRIIEELR 533
Cdd:pfam12128  222 QVEHWIRDIQAIAgIMKIRPEFTKLQQeFNTLESAEL----RLSHLHFGYKSDET----LIASRQEERQETSAELNQLLR 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  534 EQLKDLKGKYEGASAEVGKLRSQIKQsemlvgefKRDEGRLVEENKR--LQKECGTCEVELERRGRRVVELEGQLKELGA 611
Cdd:pfam12128  294 TLDDQWKEKRDELNGELSAADAAVAK--------DRSELEALEDQHGafLDADIETAAADQEQLPSWQSELENLEERLKA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  612 KL-ALSVPTEKFESMKSSLSNDINEKVKRLAE--------VGRDYESAQGEIRQLKRDLESVRAQHIRP--EEHEQLRSR 680
Cdd:pfam12128  366 LTgKHQDVTAKYNRRRSKIKEQNNRDIAGIKDklakireaRDRQLAVAEDDLQALESELREQLEAGKLEfnEEEYRLKSR 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  681 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKL--LNQQVHSLTVEmktryvpLRVSEEMKKSHDVNVEDLNKKLSEA 758
Cdd:pfam12128  446 LGELKLRLNQATATPELLLQLENFDERIERAREEQeaANAEVERLQSE-------LRQARKRRDQASEALRQASRRLEER 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  759 TQRYTEKKQ----EAERLLA--------ENDKLTKNVSR--LEAVFVAPEKHEKELMGlKSNIAELKKQLSELNKKCGEG 824
Cdd:pfam12128  519 QSALDELELqlfpQAGTLLHflrkeapdWEQSIGKVISPelLHRTDLDPEVWDGSVGG-ELNLYGVKLDLKRIDVPEWAA 597

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  825 QEKirALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL---------- 894
Cdd:pfam12128  598 SEE--ELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEkdkknkalae 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  895 --------RRNLENVQNQMKADYVSLEEHSRRMS-----TVSQSLKEAQEANAAILADHRQGQE-EIVSLHAEIKAQKKE 960
Cdd:pfam12128  676 rkdsanerLNSLEAQLKQLDKKHQAWLEEQKEQKreartEKQAYWQVVEGALDAQLALLKAAIAaRRSGAKAELKALETW 755

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  961 LDT--------------IQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKcrqRDEEVKKGKQENERLRADLAA 1026
Cdd:pfam12128  756 YKRdlaslgvdpdviakLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPR---LATQLSNIERAISELQQQLAR 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1027 LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREklVEEKAKQASEILAA-QNLLQKQPVPLEQVE 1105
Cdd:pfam12128  833 LIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDAN--SEQAQGSIGERLAQlEDLKLKRDYLSESVK 910

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720432849 1106 ALKKSLNGTI------------EQLKEELRS---KQRCLEREQQTVSQLQQLL 1143
Cdd:pfam12128  911 KYVEHFKNVIadhsgsglaetwESLREEDHYqndKGIRLLDYRKLVPYLEQWF 963
PRK11281 PRK11281
mechanosensitive channel MscK;
1219-1356 6.40e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1219 TKNDLETQISNLNDklaslnRKYDQAcEEKVSAKD-EKELLHLsieQEIRDQKERCDkslttimELQQRIQESakqieak 1297
Cdd:PRK11281    37 TEADVQAQLDALNK------QKLLEA-EDKLVQQDlEQTLALL---DKIDRQKEETE-------QLKQQLAQA------- 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849 1298 DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQrVRDLQQQLADADRQ 1356
Cdd:PRK11281    93 PAKLRQAQAELEALKDDNDEETRETLSTLSLRQLESRLAQTLDQ-LQNAQNDLAEYNSQ 150
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 580-1209 6.72e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.40  E-value: 6.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  580 RLQKECGTCEVELERRGRRVVELEGQLKELGAKLA------------LSVPTEKF---ESMKSSLSNdineKVKRLAEVG 644
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQqlceeknalqeqLQAETELCaeaEEMRARLAA----RKQELEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  645 RDYESAQGEIRQLKRDLESVR---AQHIRP-----EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLL 716
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKkkmQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  717 NQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLseatqryteKKQEAERLlaendKLTKNVSRLEAvfvapekh 796
Cdd:pfam01576  158 EERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL---------KKEEKGRQ-----ELEKAKRKLEG-------- 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  797 ekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS--------ENSSLKKTLSSQYVPAKTHEEVKAslnstvEKTNR 868
Cdd:pfam01576  216 --ESTDLQEQIAELQAQIAELRAQLAKKEEELQAALArleeetaqKNNALKKIRELEAQISELQEDLES------ERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  869 ALLEAKKRfddtsqevsKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQgqeeiv 948
Cdd:pfam01576  288 NKAEKQRR---------DLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQ------ 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  949 slhaeikAQKKELDTIQEciklkyaplaRLEECERKFKATEKGlKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1028
Cdd:pfam01576  353 -------KHTQALEELTE----------QLEQAKRNKANLEKA-KQALESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1029 KELQDRNALAEEAREAERALSGKadeLSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ---KQPVPL-EQV 1104
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSK---LQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQeetRQKLNLsTRL 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1105 EALKKSLNGTIEQLKEELRSKQRcLEREQQTV-SQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQK 1183
Cdd:pfam01576  492 RQLEDERNSLQEQLEEEEEAKRN-VERQLSTLqAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDK 570

                          650       660       670
                   ....*....|....*....|....*....|...
gi 1720432849 1184 KTKEVSKLQTE-------VQTTKQALKNLETRE 1209
Cdd:pfam01576  571 LEKTKNRLQQElddllvdLDHQRQLVSNLEKKQ 603
PRK11281 PRK11281
mechanosensitive channel MscK;
804-1024 6.79e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 6.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  804 KSNIAELKKQLSELNKKCGEGQEKIRALMSEN-SSLKKTLSSQYVPaktheevkaSLNSTVEKTNRALLEAKKRFDDT-S 881
Cdd:PRK11281    79 KEETEQLKQQLAQAPAKLRQAQAELEALKDDNdEETRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYnS 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  882 QEVSklrdenevLRRNLENVQNQMKADyvsleehSRRMSTVSQSLKEAQEANAAILADHRQG-QEEIVSLHAEIKAQKKE 960
Cdd:PRK11281   150 QLVS--------LQTQPERAQAALYAN-------SQRLQQIRNLLKGGKVGGKALRPSQRVLlQAEQALLNAQNDLQRKS 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  961 L---DTIQECIKLKY----APLARLEE---------CERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1024
Cdd:PRK11281   215 LegnTQLQDLLQKQRdyltARIQRLEHqlqllqeaiNSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRL 294
46 PHA02562
endonuclease subunit; Provisional
 1113-1315 6.84e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 6.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1113 GTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQknssvtLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1192
Cdd:PHA02562   163 SVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQ------IKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEI 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1193 TEVQTtkqALKNLetreVVDMSKYKATKNDLETQISNLNDKLASLNRKYD--------QACEEKVSAKDEKEllhlsieQ 1264
Cdd:PHA02562   237 EELTD---ELLNL----VMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcPTCTQQISEGPDRI-------T 302

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720432849 1265 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQAL 1315
Cdd:PHA02562   303 KIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1123-1318 7.40e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 7.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1123 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQAL 1202
Cdd:COG1579      3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1203 KNLET-REVVDMSK----YKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksl 1277
Cdd:COG1579     83 GNVRNnKEYEALQKeiesLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE----- 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1720432849 1278 ttIMELQQRIQESAKQIEAkdnkitELLNDVERLKQALNGL 1318
Cdd:COG1579    158 --LEELEAEREELAAKIPP------ELLALYERIRKRKNGL 190
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 857-1035 9.28e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 9.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  857 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQE 931
Cdd:COG3883     40 DALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSVSYLdvllgSESFSDFLD 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  932 ANAAILADHRQGQEEIvslhAEIKAQKKELDTIQECIKLKyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK 1011
Cdd:COG3883    120 RLSALSKIADADADLL----EELKADKAELEAKKAELEAK---LAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEA 192

                          170       180
                   ....*....|....*....|....
gi 1720432849 1012 KGKQENERLRADLAALQKELQDRN 1035
Cdd:COG3883    193 AAEAQLAELEAELAAAEAAAAAAA 216
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 752-1306 1.01e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.89  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  752 NKKLSEATQRYTEKK-QEAERLLAENDKLTKNVSRLE-AVFVAPEKHEKELMGLKSNIAELKKQLSEL-------NKKCG 822
Cdd:TIGR01612  524 NIIGFDIDQNIKAKLyKEIEAGLKESYELAKNWKKLIhEIKKELEEENEDSIHLEKEIKDLFDKYLEIddeiiyiNKLKL 603

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  823 EGQEKIRALMSENSSLKKTLSSQYV---------------PAKTHEEVKA--SLNSTVEKTNRALLEAKkrFDDTSQEVS 885
Cdd:TIGR01612  604 ELKEKIKNISDKNEYIKKAIDLKKIiennnayidelakisPYQVPEHLKNkdKIYSTIKSELSKIYEDD--IDALYNELS 681

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  886 KLRDENEVlrrnlENVQNQMKadyvsLEEHSRRMSTVSQSLKEAqeanaailadhrqgQEEIVSLH-AEIKAQKKEL-DT 963
Cdd:TIGR01612  682 SIVKENAI-----DNTEDKAK-----LDDLKSKIDKEYDKIQNM--------------ETATVELHlSNIENKKNELlDI 737

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  964 IQECIKLKYAPLAR-LEECERKFKATEKGLKEQLS------EQTHKCRQRDEEVKkgKQENERLRADlaalQKELQDRNA 1036
Cdd:TIGR01612  738 IVEIKKHIHGEINKdLNKILEDFKNKEKELSNKINdyakekDELNKYKSKISEIK--NHYNDQINID----NIKDEDAKQ 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1037 LAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLV------EEKAKQASEILAAQNLLQKQPVPLEQVEALKKS 1110
Cdd:TIGR01612  812 NYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFInfenncKEKIDSEHEQFAELTNKIKAEISDDKLNDYEKK 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1111 LNGTIEQLKEELRSkqrcLEREQQTVSQLQ------QLLENQKNSSVTL-AEHLKLKEALEKEVGIMKASlreKEEESQK 1183
Cdd:TIGR01612  892 FNDSKSLINEINKS----IEEEYQNINTLKkvdeyiKICENTKESIEKFhNKQNILKEILNKNIDTIKES---NLIEKSY 964

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1184 KTKEVSKLQTEVQTTKQALKNLEtrevvdMSKYKATKNDLETQISNLNDKLASL--NRKYDQAceekvsakDEKELLHLS 1261
Cdd:TIGR01612  965 KDKFDNTLIDKINELDKAFKDAS------LNDYEAKNNELIKYFNDLKANLGKNkeNMLYHQF--------DEKEKATND 1030

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 1720432849 1262 IEQEIRDqkerCDKSLTTI-MELQQRIQESAKQIEAKDNKITELLN 1306
Cdd:TIGR01612 1031 IEQKIED----ANKNIPNIeIAIHTSIYNIIDEIEKEIGKNIELLN 1072
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-213 1.02e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.28  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  137 IQLLCDHGASVNAKDIDGRTPL--VLATQ-MCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLVKNG 210
Cdd:PHA02798    92 VKILIENGADINKKNSDGETPLycLLSNGyINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKG 171


                   ...
gi 1720432849  211 ADL 213
Cdd:PHA02798   172 VDI 174
PRK01156 PRK01156
chromosome segregation protein; Provisional
 705-1257 1.06e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.74  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  705 DVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS 784
Cdd:PRK01156   160 EINSLERNYDKLKDVIDMLRAEISN----IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYN 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  785 RLEAVFVAPEKHEKELMGLKSNIAELKKQLS---ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTH--------E 853
Cdd:PRK01156   236 NLKSALNELSSLEDMKNRYESEIKTAESDLSmelEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDienkkqilS 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  854 EVKASLN---------STVEKTNRALLEAKKRFDDTSQEVSKLR---DENEVLRRNLENVQNQMKADYVSLEEHSRRMST 921
Cdd:PRK01156   316 NIDAEINkyhaiikklSVLQKDYNDYIKKKSRYDDLNNQILELEgyeMDYNSYLKSIESLKKKIEEYSKNIERMSAFISE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  922 VSQSLKEAQEANAAILADHRQGQEEI----VSLHAEIKAQKKELDTIQECIKL----KYAPLARLEECERKFKATEKGLK 993
Cdd:PRK01156   396 ILKIQEIDPDAIKKELNEINVKLQDIsskvSSLNQRIRALRENLDELSRNMEMlngqSVCPVCGTTLGEEKSNHIINHYN 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  994 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1073
Cdd:PRK01156   476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1074 EKL----VEEKAKQASEILAAQNLLQKQPVPlEQVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQLQQLLENQ 1146
Cdd:PRK01156   556 KSLkledLDSKRTSWLNALAVISLIDIETNR-SRSNEIKKQLNDLESRLQEieiGFPDDKSYIDKSIREIENEANNLNNK 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1147 KNssvtLAEHLK-LKEALEKEVGIMKASLREKEEeSQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLET 1225
Cdd:PRK01156   635 YN----EIQENKiLIEKLRGKIDNYKKQIAEIDS-IIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRT 709

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1720432849 1226 QISNLNDKLASLNRKYDQACEEKVSAKDEKEL 1257
Cdd:PRK01156   710 RINELSDRINDINETLESMKKIKKAIGDLKRL 741
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1051-1322 1.08e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 43.67  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS--EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRC 1128
Cdd:PTZ00440   451 KINELKKSINQLKTLISIMKSFYDLIISEKDSMDSkeKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKNIEDYYIT 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 LEREQQTVSQLQQLLENQKNSSVTLAEHlklkealEKEVGIMKASLREK---EEESQKKTKEVSKLQTEVQTTKQALKNL 1205
Cdd:PTZ00440   531 IEGLKNEIEGLIELIKYYLQSIETLIKD-------EKLKRSMKNDIKNKikyIEENVDHIKDIISLNDEIDNIIQQIEEL 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1206 ETREVVDMSKYKATKNDLETQISNLNDK------------LASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERC 1273
Cdd:PTZ00440   604 INEALFNKEKFINEKNDLQEKVKYILNKfykgdlqelldeLSHFLDDHKYLYHEAKSKEDLQTLLNTSKNEYEKLEFMKS 683

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1720432849 1274 DKSLTTIMELQqriQESAKQIEAKDNKITELLNDVErlKQALNGLSQLT 1322
Cdd:PTZ00440   684 DNIDNIIKNLK---KELQNLLSLKENIIKKQLNNIE--QDISNSLNQYT 727
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1050-1258 1.11e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1050 GKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSkqrcL 1129
Cdd:PRK05771    46 RKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKV--SVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----L 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1130 EREQQTVSQLQQL---LENQKNSSVTLAEHLKLKEALEKEVGImKASLREKEEESQKKTKE-----VSKLQTEVQTT--- 1198
Cdd:PRK05771   120 EQEIERLEPWGNFdldLSLLLGFKYVSVFVGTVPEDKLEELKL-ESDVENVEYISTDKGYVyvvvvVLKELSDEVEEelk 198

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849 1199 KQALKNLETREVVD----MSKYKATKNDLETQISNLNDKLASLNRKYDQ---ACEEKVSA-KDEKELL 1258
Cdd:PRK05771   199 KLGFERLELEEEGTpselIREIKEELEEIEKERESLLEELKELAKKYLEellALYEYLEIeLERAEAL 266
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 428-668 1.20e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  428 ENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 507
Cdd:COG1196    261 ELAELEAELEELRLELEELELELEEAQAEEYELLAE----LARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  508 THFLALKEHLTNEAAtgshrIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGT 587
Cdd:COG1196    337 EELEELEEELEEAEE-----ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  588 CEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 666
Cdd:COG1196    412 LLERLERLEEELEELEEALAELeEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAA 491


                   ..
gi 1720432849  667 QH 668
Cdd:COG1196    492 RL 493
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
757-1241 1.22e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  757 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnkkcgegQEKIRALmsens 836
Cdd:COG4717     54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL-------REELEKL----- 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  837 slkKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAkkrfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHS 916
Cdd:COG4717    122 ---EKLLQLLPLYQELEALEAELAELPERLEELEERL--------EELRELEEELEELEAELAELQEELEELLEQLSLAT 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  917 RrmstvsQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEcIKLKYAPLARLEECERKFKATekGLKEQL 996
Cdd:COG4717    191 E------EELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEN-ELEAAALEERLKEARLLLLIA--AALLAL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  997 SEQTHKCRQRDEEVKKGKQENERLRADLAA-LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1075
Cdd:COG4717    262 LGLGGSLLSLILTIAGVLFLVLGLLALLFLlLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1076 L---VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQtVSQLQQLLENQKNSSVT 1152
Cdd:COG4717    342 LldrIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEE-LEELEEQLEELLGELEE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1153 LAEHLKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykatknDLETQISNLND 1232
Cdd:COG4717    421 LLEALDEEELEEE--------LEELEEELEELEEELEELREELAELEAELEQLEEDGELA---------ELLQELEELKA 483


                   ....*....
gi 1720432849 1233 KLASLNRKY 1241
Cdd:COG4717    484 ELRELAEEW 492
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1054-1343 1.55e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1054 ELSKQLKDL--SQKYSDVKSEREKLVEEKAKQ--ASEIL-AAQNLLQKQPVPLEQVEALkksLNGTIEQLKEELRSKQRC 1128
Cdd:pfam07902   89 ELNLELTDTknSNLWSKIKLNNNGMLREYHNDtiKTEIVeSAEGIATRISEDTDKKLAL---INETISGIRREYQDADRQ 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 LERE-QQTVSQLQQLLENQKNssvtlaehlklkeALEKEVGIMKASLrekeeeSQKKTKEVSKLQTEVQTTKQAlknlet 1207
Cdd:pfam07902  166 LSSSyQAGIEGLKATMASDKI-------------GLQAEIQASAQGL------SQRYDNEIRKLSAKITTTSSG------ 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1208 revvdmskykaTKNDLETQISNLNDKLASLNRKYDQACEEKVSA-KDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQR 1286
Cdd:pfam07902  221 -----------TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQSTQQSTAYQISQEISNREGAVSRVQQDLDSYQRR 289

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849 1287 IQESAKQIEAkdnkitellndverLKQALNGL-SQLTYSSGSPTKRQSQLVDTLQQRV 1343
Cdd:pfam07902  290 LQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESRITQLAGLIEQKV 333
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 277-1031 1.57e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.11  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  277 QREQRE-PHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLN--EEVMVADDLE------------------SER 335
Cdd:TIGR00606  311 QRTVREkERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADrhQEHIRARDSLiqslatrleldgfergpfSER 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  336 EkLKSLLAAKEKQHEESLRTIEALKNRFK-----------YFESDHPGPGSYPSNRKEDMLHKQGQM--YTTEPQCASPG 402
Cdd:TIGR00606  391 Q-IKNFHTLVIERQEDEAKTAAQLCADLQskerlkqeqadEIRDEKKGLGRTIELKKEILEKKQEELkfVIKELQQLEGS 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  403 IPPHMHSRSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALA--LECERVKEDSDE 480
Cdd:TIGR00606  470 SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTqmEMLTKDKMDKDE 549

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  481 QI-----------------------------------KQLEDALKDVQKRMYESEgkvkQMQTHFLALKEHLTNEAATGS 525
Cdd:TIGR00606  550 QIrkiksrhsdeltsllgyfpnkkqledwlhskskeiNQTRDRLAKLNKELASLE----QNKNHINNELESKEEQLSSYE 625

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  526 HRIIEELREQlkDLKGKYEGASAEVGKLRsqiKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEvelerrgrRVVELEGQ 605
Cdd:TIGR00606  626 DKLFDVCGSQ--DEESDLERLKEEIEKSS---KQRAMLAGATAVYSQFITQLTDENQSCCPVCQ--------RVFQTEAE 692

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  606 LKELGAKL---ALSVPTEkfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRL 681
Cdd:TIGR00606  693 LQEFISDLqskLRLAPDK-----LKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKvNRDIQRLKNDI 767

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  682 EQKSGELGKKVSELTLKnQTLQKDVEKLhadnkllnQQVHSLTVEMKTRYVPLrVSEEMKKSHDVNVEDLNKKLSEATQR 761
Cdd:TIGR00606  768 EEQETLLGTIMPEEESA-KVCLTDVTIM--------ERFQMELKDVERKIAQQ-AAKLQGSDLDRTVQQVNQEKQEKQHE 837

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  762 YTEKKQEAErllaENDKLTknvsrleavfvapEKHEKELMGLKSNIAELKK---QLSELNKKCGEGQEKIRALMSENSSL 838
Cdd:TIGR00606  838 LDTVVSKIE----LNRKLI-------------QDQQEQIQHLKSKTNELKSeklQIGTNLQRRQQFEEQLVELSTEVQSL 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  839 KKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSrr 918
Cdd:TIGR00606  901 IREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETE-- 978

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  919 MSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKyaplarleECERKFKATEKGLKE-QLS 997
Cdd:TIGR00606  979 LNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELK--------EVEEELKQHLKEMGQmQVL 1050

                          810       820       830
                   ....*....|....*....|....*....|....
gi 1720432849  998 EQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1031
Cdd:TIGR00606 1051 QMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEI 1084
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 973-1319 2.09e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.32  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  973 APLARLEECERKfkATEKGLKEQLSEQTHKCRQRDeevKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKA 1052
Cdd:pfam05667  214 AELAAAQEWEEE--WNSQGLASRLTPEEYRKRKRT---KLLKRIAEQLRSAALAGTEATSGASRSAQDLAELLSSFSGSS 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1053 DELSKQLK----DLSQKYSDVKSEREKLVEEKAKQASEilaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELrskqrc 1128
Cdd:pfam05667  289 TTDTGLTKgsrfTHTEKLQFTNEAPAATSSPPTKVETE----EELQQQREEELEELQEQLEDLESSIQELEKEI------ 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 lEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEEsqkktkeVSKLQTEVQTTKQALKNL--- 1205
Cdd:pfam05667  359 -KKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDL-------LPDAEEN-------IAKLQALVDASAQRLVELagq 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1206 -ETREVVDMSKY---KATKNDLETQISNLNDKLASLNRKYdQACEEKVSAKDE--KELLhlsieqeirDQKERCDKSlTT 1279
Cdd:pfam05667  424 wEKHRVPLIEEYralKEAKSNKEDESQRKLEEIKELREKI-KEVAEEAKQKEElyKQLV---------AEYERLPKD-VS 492

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1720432849 1280 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1319
Cdd:pfam05667  493 RSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1015-1293 2.31e-03

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 42.45  E-value: 2.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1015 QENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQ---KYSDVKSEREKLVEEKA--KQASEILA 1089
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGK-ALNFNKAVAEAKSTGNYDEVKKAQKDLEKslrKREHLEKEVEKKLESKSgnKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1090 AQNLLQKQPVPLEQVEALKKS----LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH-LKLKEALE 1164
Cdd:pfam18971  652 QANSQKDEIFALINKEANRDAraiaYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEEtLKALKGSV 731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1165 KEVGImkaslrekeeesqkKTKEVSKlqteVQTTKQALKNLETREVVDMSKYKATKNDLETQISN------LNDKLASLN 1238
Cdd:pfam18971  732 KDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviinqkVTDKVDNLN 793

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849 1239 RKYDQACEEKVSAKDEK---ELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ 1293
Cdd:pfam18971  794 QAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1102-1320 2.35e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1102 EQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQllenqKNSSVTLAEHLKLkeaLEKEVGIMKASLREKEEES 1181
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKL---LLQQLSELESQLAEARAEL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1182 QKKTKEVSKLQTEVQTTKQALKNLETREVVdmSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLS 1261
Cdd:COG3206    236 AEAEARLAALRAQLGSGPDALPELLQSPVI--QQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQR 313

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849 1262 IEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQ 1320
Cdd:COG3206    314 ILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQ 372
PRK11281 PRK11281
mechanosensitive channel MscK;
1051-1394 2.41e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1051 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNL--LQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRC 1128
Cdd:PRK11281    81 ETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQ 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1129 LEREQQTVS----QLQQ---LLENQKNSSVTLAEHLKLKEALEkevgimKASLREKEEESQKKTKEVSKLQtEVQTTKQA 1201
Cdd:PRK11281   158 PERAQAALYansqRLQQirnLLKGGKVGGKALRPSQRVLLQAE------QALLNAQNDLQRKSLEGNTQLQ-DLLQKQRD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1202 LKNLETrevvdmskykatkNDLETQISNLNDklaSLNRKYDQACEEKVSakdekellhlsiEQEIRDQKERCDKSLTTIM 1281
Cdd:PRK11281   231 YLTARI-------------QRLEHQLQLLQE---AINSKRLTLSEKTVQ------------EAQSQDEAARIQANPLVAQ 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1282 ELQQRIQESAKQIEAKDnKITELLNDVERLKQALNGLSQltysSGSPTKRQ-SQLVDTL-------QQR--------VRD 1345
Cdd:PRK11281   283 ELEINLQLSQRLLKATE-KLNTLTQQNLRVKNWLDRLTQ----SERNIKEQiSVLKGSLllsrilyQQQqalpsadlIEG 357

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849 1346 LQQQLADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGL 1394
Cdd:PRK11281   358 LADRIADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 430-1210 2.45e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  430 EILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALAleceRVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTH 509
Cdd:pfam01576  359 EELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQ----QAKQDSEHKRKKLEGQLQELQARLSESE-RQRAELAE 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  510 FLAlkeHLTNEaatgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCE 589
Cdd:pfam01576  434 KLS---KLQSE--------LESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQ 502

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  590 VELERRGRRVVELEGQLKELGAKLAlsvptekfesmksslsndinEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHi 669
Cdd:pfam01576  503 EQLEEEEEAKRNVERQLSTLQAQLS--------------------DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQL- 561

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  670 rpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsLTVEMKTryVPLRVSEEMKKSHDVNVE 749
Cdd:pfam01576  562 --EEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQ----MLAEEKA--ISARYAEERDRAEAEARE 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  750 DLNKKLS--EATQRYTEKKQEAER----LLAENDKLtknVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 823
Cdd:pfam01576  634 KETRALSlaRALEEALEAKEELERtnkqLRAEMEDL---VSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQA 710

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  824 gqekiralmSENSSLKKTLSSQYVPAK----------THEEVKASLNSTV---------EKTNRAL-LEAKKRFDDTSQE 883
Cdd:pfam01576  711 ---------TEDAKLRLEVNMQALKAQferdlqardeQGEEKRRQLVKQVreleaeledERKQRAQaVAAKKKLELDLKE 781

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  884 -------VSKLRDEnevLRRNLENVQNQMKADYVSLEE-HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIK 955
Cdd:pfam01576  782 leaqidaANKGREE---AVKQLKKLQAQMKDLQRELEEaRASRDEILAQS-KESEKKLKNLEAELLQLQEDLAASERARR 857

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  956 AQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1035
Cdd:pfam01576  858 QAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQ--- 934

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1036 alaeeareaerALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQASEILAAQnllqkqpvpLEQVEalkkslngti 1115
Cdd:pfam01576  935 -----------KSESARQQLERQNKELKAKL----QEMEGTVKSKFKSSIAALEAK---------IAQLE---------- 980

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1116 EQLKEELRSKQ---RCLEREQQTVSQLQQLLENQKNSSVTLAEHLklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1192
Cdd:pfam01576  981 EQLEQESRERQaanKLVRRTEKKLKEVLLQVEDERRHADQYKDQA---EKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057

                          810
                   ....*....|....*...
gi 1720432849 1193 TEVQTTKQALKNLeTREV 1210
Cdd:pfam01576 1058 RELDDATESNESM-NREV 1074
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 479-1203 2.47e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  479 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLT------NEAATGSHRII---EELREQLKDLKGKYEGASAE 549
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcAEAEEMRARLAarkQELEEILHELESRLEEEEER 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  550 VGKLRSQIKQSEMLVGEFkrdEGRLVEEN---KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMK 626
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDL---EEQLDEEEaarQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL--EERISEFT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  627 SSLSNDiNEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGELGKKVSELT-----LKNQT 701
Cdd:pfam01576  166 SNLAEE-EEKAKSLSKLKNKHEAMISDLEERLKKEEKGR------QELEKAKRKLEGESTDLQEQIAELQaqiaeLRAQL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  702 LQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMkkshdvnvEDLNKKLSEATQRYTEKKQEAERLLAENDKLTK 781
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQ--------EDLESERAARNKAEKQRRDLGEELEALKTELED 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  782 NVSRLEAVFVAPEKHEKELMGLKSNIAELKK----QLSELNKKCGEGQEKI------------------RALMSENSSLK 839
Cdd:pfam01576  311 TLDTTAAQQELRSKREQEVTELKKALEEETRsheaQLQEMRQKHTQALEELteqleqakrnkanlekakQALESENAELQ 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  840 KTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRM 919
Cdd:pfam01576  391 AEL-------RTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDV 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  920 STVSQSLKEAQEanaailadhrQGQEEI---VSLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEK---GLK 993
Cdd:pfam01576  464 SSLESQLQDTQE----------LLQEETrqkLNLSTRLRQLEDERNSLQE----------QLEEEEEAKRNVERqlsTLQ 523

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  994 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1073
Cdd:pfam01576  524 AQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQ 603

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1074 EK----LVEEKAkqaseiLAAQNLLQKQPVPLEQVEALKKSLNGTIEqLKEELRSKQRCLEREQQTVSQLQQLLENQKNS 1149
Cdd:pfam01576  604 KKfdqmLAEEKA------ISARYAEERDRAEAEAREKETRALSLARA-LEEALEAKEELERTNKQLRAEMEDLVSSKDDV 676

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720432849 1150 SVTLAEHLKLKEALEKEVGIMKASLREKEEESQkkTKEVSKLQTEVqtTKQALK 1203
Cdd:pfam01576  677 GKNVHELERSKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLEV--NMQALK 726
PHA02946 PHA02946
ankyin-like protein; Provisional
 137-213 2.92e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 2.92e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432849  137 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLVKNGADL 213
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKI 133
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 954-1295 3.02e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 41.75  E-value: 3.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  954 IKAqKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEqLSEQTHKCRQRDEEVKKGKQEnerlradlaaLQKELQD 1033
Cdd:PRK04778   101 RKA-KHEINEIES----------LLDLIEEDIEQILEELQE-LLESEEKNREEVEQLKDLYRE----------LRKSLLA 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1034 RNALAeeareaeralsGKA-DELSKQLKDLsqkysdvKSEREKLVEEKAK----QASEILAAQ----NLLQKQpvpLEQV 1104
Cdd:PRK04778   159 NRFSF-----------GPAlDELEKQLENL-------EEEFSQFVELTESgdyvEAREILDQLeeelAALEQI---MEEI 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1105 EALKKSLNGTI-EQLkEELRSKQRCLERE------QQTVSQLQQLLENQKNSSVTLAEhLKLKEALEKEVGIMKA----- 1172
Cdd:PRK04778   218 PELLKELQTELpDQL-QELKAGYRELVEEgyhldhLDIEKEIQDLKEQIDENLALLEE-LDLDEAEEKNEEIQERidqly 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1173 SLREKEEESQKK-TKEVSKLQTEVQTTKQALKNL--ETREVvdMSKYKATKNDLETQiSNLNDKLASLNRKYDQACEEKv 1249
Cdd:PRK04778   296 DILEREVKARKYvEKNSDTLPDFLEHAKEQNKELkeEIDRV--KQSYTLNESELESV-RQLEKQLESLEKQYDEITERI- 371

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1720432849 1250 sakDEKELLHlsieQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1295
Cdd:PRK04778   372 ---AEQEIAY----SELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 937-1200 3.02e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.98  E-value: 3.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  937 LADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK------FKATEKGLKEQLSEQTHKCRQRDEEV 1010
Cdd:pfam05622   96 VLELQHRNEELTSLAEEAQALKDEMDILRESSDKVKKLEATVETYKKKledlgdLRRQVKLLEERNAEYMQRTLQLEEEL 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1011 KKGKQenerLRADLAALQKELQDrnalaeeAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK-------- 1082
Cdd:pfam05622  176 KKANA----LRGQLETYKRQVQE-------LHGKLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIERDTlretneel 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1083 -----QASEILAAQNLLQKQPVPLEQV--EALKKSLNGTIEQLKEE---LRSKQRCLEREQQTVsqLQQLLENQKNSSVT 1152
Cdd:pfam05622  245 rcaqlQQAELSQADALLSPSSDPGDNLaaEIMPAEIREKLIRLQHEnkmLRLGQEGSYRERLTE--LQQLLEDANRRKNE 322

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432849 1153 LAEHLKLKE----------------------------ALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1200
Cdd:pfam05622  323 LETQNRLANqrilelqqqveelqkalqeqgskaedssLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLA 398
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-181 3.35e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 3.35e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720432849  153 DGRTPLVLATQMCRPTICQLLIDRGADVN 181
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1101-1389 3.72e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 3.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1101 LEQVEALKKSLnGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTlaEHLKLKEALEKEVGIMKASLREKEEE 1180
Cdd:TIGR02169  176 LEELEEVEENI-ERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGY--ELLKEKEALERQKEAIERQLASLEEE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1181 SQKKTKEVSKLQTEVQTTKQALKNLETReVVDMSKYKAtkNDLETQISNLNDKLASLNRKYDQAceekvsakdekellhl 1260
Cdd:TIGR02169  253 LEKLTEEISELEKRLEEIEQLLEELNKK-IKDLGEEEQ--LRVKEKIGELEAEIASLERSIAEK---------------- 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1261 siEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQltyssgsPTKRQSQLVDTLQ 1340
Cdd:TIGR02169  314 --ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRA-------ELEEVDKEFAETR 384

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1341 QRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQGHMD-EDVQAALLQIIQ 1389
Cdd:TIGR02169  385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEElADLNAAIAGIEA 434
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
527-719 3.75e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 3.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  527 RIIEELREQLKDLKGKYEGASAEVGKLRSQiKQSEMLVGEFKRDEGRLVEENKRLQkecgtcEVELERRgrrvvELEGQL 606
Cdd:COG3206    175 KALEFLEEQLPELRKELEEAEAALEEFRQK-NGLVDLSEEAKLLLQQLSELESQLA------EARAELA-----EAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  607 KELGAKLALS---VPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQhirpeeheqLRSRLEQ 683
Cdd:COG3206    243 AALRAQLGSGpdaLPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQ---------LQQEAQR 313

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1720432849  684 KSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQ 719
Cdd:COG3206    314 ILASLEAELEALQAREASLQAQLAQLEARLAELPEL 349
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1076-1304 3.77e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 41.73  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1076 LVEEKAKQASEILAAQNLLQkqpVPLEQVEALKKSlngtIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1155
Cdd:pfam10174  371 LTEEKSTLAGEIRDLKDMLD---VKERKINVLQKK----IENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEE 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1156 HLKLK----EALEKEVGIMKASLREKEEESQKKTKE----VSKLQTEVQTTKQAL-------KNLETREVVDMSKYKATK 1220
Cdd:pfam10174  444 ALSEKeriiERLKEQREREDRERLEELESLKKENKDlkekVSALQPELTEKESSLidlkehaSSLASSGLKKDSKLKSLE 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1221 NDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1300
Cdd:pfam10174  524 IAVEQKKEECSKLENQLKKAHNAEEAVRTNPEINDRIRLL--EQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKK 601


                   ....
gi 1720432849 1301 ITEL 1304
Cdd:pfam10174  602 IAEL 605
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1081-1342 4.23e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 4.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1081 AKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNGTIEQLKEELRSK--QRCLEREQQTVSQLQQLLENQKNSSVTLA 1154
Cdd:PRK10929    20 ATAPDEKQITQELEQakaaKTPAQAEIVEALQSALNWLEERKGSLERAKqyQQVIDNFPKLSAELRQQLNNERDEPRSVP 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1155 EHLKLKEaLEKEVGIMKASLREKEEESQK---KTKEVS-------KLQTEvqtTKQALKNLETREvvdMSKYKATKNDLE 1224
Cdd:PRK10929   100 PNMSTDA-LEQEILQVSSQLLEKSRQAQQeqdRAREISdslsqlpQQQTE---ARRQLNEIERRL---QTLGTPNTPLAQ 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1225 TQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSL----TTIMELQQRIQESA--------K 1292
Cdd:PRK10929   173 AQLTALQAESAALKALVDELELAQLSANNRQELARLRSEL-AKKRSQQLDAYLqalrNQLNSQRQREAERAlestellaE 251

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720432849 1293 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSptkRQSQLV-DTLQQR 1342
Cdd:PRK10929   252 QSGDLPKSIVAQFKINRELSQALNQQAQRMDLIAS---QQRQAAsQTLQVR 299
Ank_5 pfam13857
Ankyrin repeats (many copies);
142-191 4.37e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 4.37e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1720432849  142 DHG-ASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 62-162 4.74e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 4.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849   62 VASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL- 140
Cdd:PTZ00322    89 LAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLs 168

                           90       100
                   ....*....|....*....|....*...
gi 1720432849  141 ----CDHGASVNAK--DIDGRTPLVLAT 162
Cdd:PTZ00322   169 rhsqCHFELGANAKpdSFTGKPPSLEDS 196
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 754-966 4.85e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 4.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  754 KLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 833
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNE----------EYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  834 EnssLKKTLSSQYVPAKTHEEVKASLNST--VEKTNRALLEAK--KRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 909
Cdd:COG3883     87 E---LGERARALYRSGGSVSYLDVLLGSEsfSDFLDRLSALSKiaDADADLLEELKADKAELEAKKAELEAKLAELEALK 163

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849  910 VSLEEhsrRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQE 966
Cdd:COG3883    164 AELEA---AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAA 217
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1081-1300 5.23e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 5.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1081 AKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ-QLLENQKNSSVTLAEHLKL 1159
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEqELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1160 KEALEKEVGIMKASLREKEEESQKKTKEV---SKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1236
Cdd:COG4942     96 RAELEAQKEELAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432849 1237 LNRKYDQACEEKV---SAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1300
Cdd:COG4942    176 LEALLAELEEERAaleALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
929-1135 5.54e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 5.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  929 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplaRLEECERkfkatekgLKEQLSEQThKCRQRDE 1008
Cdd:COG4913    608 NRAKLAALEAELAELEEELAEAEERLEALEAELDALQE----------RREALQR--------LAEYSWDEI-DVASAER 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1009 EVKKGKQENERLRA---DLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS 1085
Cdd:COG4913    669 EIAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1086 EILAAQNLLQKQPvplEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT 1135
Cdd:COG4913    749 ALLEERFAAALGD---AVERELRENLEERIDALRARLNRAEEELERAMRA 795
PLN02939 PLN02939
transferase, transferring glycosyl groups
 525-911 5.89e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.04  E-value: 5.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  525 SHRIIEEL----REQLKDLKGKYEGASAEVGKLRSQIKQSE---MLVGEFK----RDEGRLVEENKRLQKECGTCEVELE 593
Cdd:PLN02939   101 SMQRDEAIaaidNEQQTNSKDGEQLSDFQLEDLVGMIQNAEkniLLLNQARlqalEDLEKILTEKEALQGKINILEMRLS 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  594 RRGRRVVeLEGQlkelgAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEE 673
Cdd:PLN02939   181 ETDARIK-LAAQ-----EKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  674 HEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhadnkllnqqvhsltvemktryVPLRVSEEMKKshdvnVEDLNK 753
Cdd:PLN02939   255 TEERVFKLEKERSLLDASLRELESKFIVAQEDVSKL----------------------SPLQYDCWWEK-----VENLQD 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  754 KLSEATQRytekKQEAERLLAENDKLTKNVSRLEAVFVApekhekelmglkSNIAELKKQLSELNkkcgegQEKIRALMS 833
Cdd:PLN02939   308 LLDRATNQ----VEKAALVLDQNQDLRDKVDKLEASLKE------------ANVSKFSSYKVELL------QQKLKLLEE 365

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720432849  834 EnsslkktlsSQYVPAKTHEEVKASLNSTVEktnralleakkrFDDTsqeVSKLRDENEvlRRNLENVQNQMKADYVS 911
Cdd:PLN02939   366 R---------LQASDHEIHSYIQLYQESIKE------------FQDT---LSKLKEESK--KRSLEHPADDMPSEFWS 417
Ank_4 pfam13637
Ankyrin repeats (many copies);
154-207 5.98e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720432849  154 GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLV 207
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 278-603 6.83e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  278 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 357
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  358 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 437
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  438 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 514
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  515 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 594
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 1720432849  595 RGRRVVELE 603
Cdd:TIGR02169  936 IEDPKGEDE 944
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1074-1196 8.70e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.58  E-value: 8.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1074 EKLVEEKAKQASEILAAQNLLQkqpvpleQVEALKKSLNGTIEQLKEELRSKQRCLERE-QQTVSQ--------LQQLLE 1144
Cdd:PRK00409   523 ASLEELERELEQKAEEAEALLK-------EAEKLKEELEEKKEKLQEEEDKLLEEAEKEaQQAIKEakkeadeiIKELRQ 595

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1720432849 1145 NQKNSSVTLAEHlKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQ 1196
Cdd:PRK00409   596 LQKGGYASVKAH-ELIEARKR--------LNKANEKKEKKKKKQKEKQEELK 638
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 924-1392 9.77e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 9.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  924 QSLKEAQEANAAILADhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK--------FKATEKGLKEQ 995
Cdd:TIGR00618  156 QFLKAKSKEKKELLMN-LFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849  996 LSE--QTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1073
Cdd:TIGR00618  235 LQQtqQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQ-EAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIH 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1074 EKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT-----VSQLQQLLENQKN 1148
Cdd:TIGR00618  314 TELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1149 SSVTLAEHLKLKEALEKEVGIMKASLR---------EKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdMSKYKAt 1219
Cdd:TIGR00618  394 KLQSLCKELDILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQES--AQSLKE- 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1220 KNDLETQISNLNDKLASLNRKYDQACEEKVSAKD--EKELLHLSIEQEIRDQKE----RCDKSLTTIMELQQRIQESAKQ 1293
Cdd:TIGR00618  471 REQQLQTKEQIHLQETRKKAVVLARLLELQEEPCplCGSCIHPNPARQDIDNPGpltrRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1294 IEAKDNKITELLNDVERLKQALNGLSQLTYSSgsptkrqSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQ 1373
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRS-------KEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQP 623

                          490
                   ....*....|....*....
gi 1720432849 1374 GHMDEDVQAALLQIIQMRQ 1392
Cdd:TIGR00618  624 EQDLQDVRLHLQQCSQELA 642
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1086-1349 9.80e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.45  E-value: 9.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1086 EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvTLAEHLKLKEALEK 1165
Cdd:COG5022    763 RYLQALKRIKKIQVIQHGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQK----TIKREKKLRETEEV 838

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1166 EVGIMKASLREKEEESQKKTKEVSKLQTEV--QTTKQALKNLETR------EVVDMSKYKATKNDLETQISNLND----- 1232
Cdd:COG5022    839 EFSLKAEVLIQKFGRSLKAKKRFSLLKKETiyLQSAQRVELAERQlqelkiDVKSISSLKLVNLELESEIIELKKslssd 918

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432849 1233 -------------KLASLNRKYD-------QACEEKVSAKD------------EKELLHLSIEQEIRDQKERCDKS---- 1276
Cdd:COG5022    919 lienlefkteliaRLKKLLNNIDleegpsiEYVKLPELNKLhevesklketseEYEDLLKKSTILVREGNKANSELknfk 998

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720432849 1277 --LTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGsPTKRQSQLVDTLQQRVRDLQQQ 1349
Cdd:COG5022    999 keLAELSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQK-LKGLLLLENNQLQARYKALKLR 1072
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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