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Conserved domains on  [gi|1720432810|ref|XP_030100483|]
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F-box/LRR-repeat protein 2 isoform X3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1563018)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 63-262 2.81e-30

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 114.35  E-value: 2.81e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  63 QITKEGIEALVRG-CRGLKALLLRGCTQLeDEALKHIQNhCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSN 141
Cdd:cd09293    13 QITQSNISQLLRIlHSGLEWLELYMCPIS-DPPLDQLSN-CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACEN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810 142 LTDASLTALGLNCPRLQVLEAAR---CSHLTDAGFTLLARNCHELEKMDLEECvLITDSTLVQL-SIHCPKLQALSLSHC 217
Cdd:cd09293    91 ITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELaSGCSKSLERLSLNNC 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720432810 218 ELITDEGILHLSSSTCgHERLRVLELDNCLLVTDASLEHLENCRG 262
Cdd:cd09293   170 RNLTDQSIPAILASNY-FPNLSVLEFRGCPLITDFSRIILFKLWQ 213
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 63-262 2.81e-30

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 114.35  E-value: 2.81e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  63 QITKEGIEALVRG-CRGLKALLLRGCTQLeDEALKHIQNhCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSN 141
Cdd:cd09293    13 QITQSNISQLLRIlHSGLEWLELYMCPIS-DPPLDQLSN-CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACEN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810 142 LTDASLTALGLNCPRLQVLEAAR---CSHLTDAGFTLLARNCHELEKMDLEECvLITDSTLVQL-SIHCPKLQALSLSHC 217
Cdd:cd09293    91 ITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELaSGCSKSLERLSLNNC 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720432810 218 ELITDEGILHLSSSTCgHERLRVLELDNCLLVTDASLEHLENCRG 262
Cdd:cd09293   170 RNLTDQSIPAILASNY-FPNLSVLEFRGCPLITDFSRIILFKLWQ 213
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-272 3.64e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  15 STCYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLLRGCTQLEDEA 94
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  95 LKHIQN-------------HCHELVSLNLqSCSRITDDGvvQICRGCHRLQALCLSGCsNLTDASlTALGlNCPRLQVLE 161
Cdd:COG4886    92 LGDLTNlteldlsgneelsNLTNLESLDL-SGNQLTDLP--EELANLTNLKELDLSNN-QLTDLP-EPLG-NLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810 162 AARCsHLTDAGFTLLarNCHELEKMDLEECvLITD--STLVQLsihcPKLQALSLSHCELIT-DEGILHLSSstcgherL 238
Cdd:COG4886   166 LSNN-QLTDLPEELG--NLTNLKELDLSNN-QITDlpEPLGNL----TNLEELDLSGNQLTDlPEPLANLTN-------L 230

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1720432810 239 RVLELDNCLLVtdaSLEHLENCRGLERLELYDCQ 272
Cdd:COG4886   231 ETLDLSNNQLT---DLPELGNLTNLEELDLSNNQ 261
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
206-231 6.91e-05

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 39.31  E-value: 6.91e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720432810  206 CPKLQALSLSHCELITDEGILHLSSS 231
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 63-262 2.81e-30

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 114.35  E-value: 2.81e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  63 QITKEGIEALVRG-CRGLKALLLRGCTQLeDEALKHIQNhCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSN 141
Cdd:cd09293    13 QITQSNISQLLRIlHSGLEWLELYMCPIS-DPPLDQLSN-CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACEN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810 142 LTDASLTALGLNCPRLQVLEAAR---CSHLTDAGFTLLARNCHELEKMDLEECvLITDSTLVQL-SIHCPKLQALSLSHC 217
Cdd:cd09293    91 ITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELaSGCSKSLERLSLNNC 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720432810 218 ELITDEGILHLSSSTCgHERLRVLELDNCLLVTDASLEHLENCRG 262
Cdd:cd09293   170 RNLTDQSIPAILASNY-FPNLSVLEFRGCPLITDFSRIILFKLWQ 213
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 23-170 1.02e-23

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 96.63  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  23 FCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLL---RGCTQLEDEALKHIQ 99
Cdd:cd09293    50 NCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLgrhRNGHLITDVSLSALG 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720432810 100 NHCHELVSLNLQSCsRITDDGVVQICRGC-HRLQALCLSGCSNLTDASLTAL--GLNCPRLQVLEAARCSHLTD 170
Cdd:cd09293   130 KNCTFLQTVGFAGC-DVTDKGVWELASGCsKSLERLSLNNCRNLTDQSIPAIlaSNYFPNLSVLEFRGCPLITD 202
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 88-279 7.08e-20

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 86.23  E-value: 7.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  88 TQLEDEALKHIQnhCHELVSLNLQSCSRITDDGVVQICrgCHRLQALCLSGCSNLTDASLTALGLNCPRLQVLEAARCSH 167
Cdd:cd09293    15 TQSNISQLLRIL--HSGLEWLELYMCPISDPPLDQLSN--CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACEN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810 168 LTDAGFTLLARNCHELEKMDL---EECVLITDSTLVQLSIHCPKLQALSLSHCElITDEGILHLSSStCGHErlrvleld 244
Cdd:cd09293    91 ITDSGIVALATNCPKLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASG-CSKS-------- 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1720432810 245 ncllvtdaslehlencrgLERLELYDCQQVTRAGI 279
Cdd:cd09293   161 ------------------LERLSLNNCRNLTDQSI 177
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-272 3.64e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  15 STCYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLLRGCTQLEDEA 94
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810  95 LKHIQN-------------HCHELVSLNLqSCSRITDDGvvQICRGCHRLQALCLSGCsNLTDASlTALGlNCPRLQVLE 161
Cdd:COG4886    92 LGDLTNlteldlsgneelsNLTNLESLDL-SGNQLTDLP--EELANLTNLKELDLSNN-QLTDLP-EPLG-NLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432810 162 AARCsHLTDAGFTLLarNCHELEKMDLEECvLITD--STLVQLsihcPKLQALSLSHCELIT-DEGILHLSSstcgherL 238
Cdd:COG4886   166 LSNN-QLTDLPEELG--NLTNLKELDLSNN-QITDlpEPLGNL----TNLEELDLSGNQLTDlPEPLANLTN-------L 230

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1720432810 239 RVLELDNCLLVtdaSLEHLENCRGLERLELYDCQ 272
Cdd:COG4886   231 ETLDLSNNQLT---DLPELGNLTNLEELDLSNNQ 261
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
206-231 6.91e-05

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 39.31  E-value: 6.91e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720432810  206 CPKLQALSLSHCELITDEGILHLSSS 231
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
50-75 2.34e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 34.69  E-value: 2.34e-03
                           10        20
                   ....*....|....*....|....*.
gi 1720432810   50 CRNLEYLNLSWCDQITKEGIEALVRG 75
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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