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Conserved domains on  [gi|1720357957|ref|XP_030099750|]
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SH3 domain-binding protein 4 isoform X2 [Mus musculus]

Protein Classification

SH3 domain-containing protein( domain architecture ID 10244083)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 557-621 1.82e-07

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


:

Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 48.36  E-value: 1.82e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357957 557 FGKLLKTVVRQNKSHylLEYKKGDVVALLSEERIrlkgqlwtkEWYIGYYQGKVGLVHTKNVLVV 621
Cdd:pfam07653   1 YGRVIFDYVGTDKNG--LTLKKGDVVKVLGKDND---------GWWEGETGGRVGLVPSTAVEEI 54
ZU5 super family cl02517
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 222-303 9.15e-06

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


The actual alignment was detected with superfamily member pfam00791:

Pssm-ID: 470600  Cd Length: 97  Bit Score: 44.83  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357957 222 LDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLD----PPLDlnsDRSTSVSPVVEVKLSNLEVSTFIILEMKVS 297
Cdd:pfam00791   5 VDSRGGRLVLPNSGVSLLIPPGAIPEGTRIECYLAVNRDessrPPLE---EGETLLSPVVECGPPGLKFLKPVILEVPHC 81


                  ....*.
gi 1720357957 298 AEVKGD 303
Cdd:pfam00791  82 ASLRPE 87
 
Name Accession Description Interval E-value
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 557-621 1.82e-07

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 48.36  E-value: 1.82e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357957 557 FGKLLKTVVRQNKSHylLEYKKGDVVALLSEERIrlkgqlwtkEWYIGYYQGKVGLVHTKNVLVV 621
Cdd:pfam07653   1 YGRVIFDYVGTDKNG--LTLKKGDVVKVLGKDND---------GWWEGETGGRVGLVPSTAVEEI 54
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 222-303 9.15e-06

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 44.83  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357957 222 LDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLD----PPLDlnsDRSTSVSPVVEVKLSNLEVSTFIILEMKVS 297
Cdd:pfam00791   5 VDSRGGRLVLPNSGVSLLIPPGAIPEGTRIECYLAVNRDessrPPLE---EGETLLSPVVECGPPGLKFLKPVILEVPHC 81


                  ....*.
gi 1720357957 298 AEVKGD 303
Cdd:pfam00791  82 ASLRPE 87
 
Name Accession Description Interval E-value
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 557-621 1.82e-07

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 48.36  E-value: 1.82e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720357957 557 FGKLLKTVVRQNKSHylLEYKKGDVVALLSEERIrlkgqlwtkEWYIGYYQGKVGLVHTKNVLVV 621
Cdd:pfam07653   1 YGRVIFDYVGTDKNG--LTLKKGDVVKVLGKDND---------GWWEGETGGRVGLVPSTAVEEI 54
ZU5 pfam00791
ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
 222-303 9.15e-06

ZU5 domain; Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.


Pssm-ID: 459941  Cd Length: 97  Bit Score: 44.83  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357957 222 LDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLD----PPLDlnsDRSTSVSPVVEVKLSNLEVSTFIILEMKVS 297
Cdd:pfam00791   5 VDSRGGRLVLPNSGVSLLIPPGAIPEGTRIECYLAVNRDessrPPLE---EGETLLSPVVECGPPGLKFLKPVILEVPHC 81


                  ....*.
gi 1720357957 298 AEVKGD 303
Cdd:pfam00791  82 ASLRPE 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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