|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
36-447 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 706.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 36 VYHAVIVIFLEFFAWGLLTAPTLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 115
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 116 PLMKIDAWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATA 195
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 196 IAVLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVME 275
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 276 FSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 355
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 356 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELDElpITETNSEDKDNLHHSQQNSIIPGPPFLFGACS 435
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNE--IKPVQSSKQRMQNPSLEGAIIPGPPFLFGAIS 398
|
410
....*....|..
gi 1717019278 436 VLLALLVALFIP 447
Cdd:cd17387 399 VLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
41-395 |
9.25e-67 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 218.22 E-value: 9.25e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLTAP-TLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 119
Cdd:cd17330 3 LVVFLDALGFGIVFPVlPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 120 IDA--WWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIA 197
Cdd:cd17330 83 LSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 198 VLDICFILVAVPeslpekmrpaswgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFS 277
Cdd:cd17330 163 LLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 278 PESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSAL 356
Cdd:cd17330 209 PSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSAL 288
|
330 340 350
....*....|....*....|....*....|....*....
gi 1717019278 357 VSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
73-404 |
1.30e-42 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 155.49 E-value: 1.30e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 73 NGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT--------VFFTCAPIplmkidAWWYFAVISVSGVFAVTFSVVFA 144
Cdd:cd17388 40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSlagaaldyLLMAFAPT------LWWLYLGRIIAGITGATGAVAAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 145 YVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSrEYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgap 224
Cdd:cd17388 114 YIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF---- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 225 iSWEQADPFASLKKVGQDSIVLLICITVFLSYLpeAGQ--YSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSL 302
Cdd:cd17388 189 -RWRRANPFGSLRWLTGFPGLLGLLAVFFLIQL--IGQvpATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 303 LMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNG 382
Cdd:cd17388 266 IAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSI 345
|
330 340
....*....|....*....|..
gi 1717019278 383 LGPALYGFIFYIFHVELDELPI 404
Cdd:cd17388 346 IGPLLFTGIFAASPATWPGLAW 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
71-396 |
3.03e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 126.54 E-value: 3.03e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 71 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMKIDAWWYFAVISV-SGVF-AVTFSVVFAYVA 147
Cdd:cd17325 31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAFATSYWQLLLARFlQGLAsAAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 148 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKmrpaswgAPISW 227
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP-------NKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 228 EQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRsI 307
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-I 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 308 GNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA-AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPA 386
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342
|
330
....*....|
gi 1717019278 387 LYGFIFYIFH 396
Cdd:cd17325 343 LGGFLYDAFG 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-383 |
1.76e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.54 E-value: 1.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 40 VIVIFLEFFAWGLLTaPTLMVLRKTFPkHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 119
Cdd:COG2814 16 ALGAFLSGLGIGIVL-PALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 120 I--DAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAI 196
Cdd:COG2814 94 LapSLWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 197 AVLDICFILVAVPESLPEKMRPASwgapisweqadpfASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEF 276
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 277 SPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSA 355
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQA 319
|
330 340
....*....|....*....|....*...
gi 1717019278 356 LVSRTADADQQGVVQGMITGIRGLCNGL 383
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
74-395 |
2.69e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 110.01 E-value: 2.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADIT 150
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 151 QEHERSMAYGLVSATFAASLVTSPAIGAYLSrEYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPaswgapiswEQA 230
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 231 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVlSLLMRSIGNK 310
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPV-ARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 311 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYG 389
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
....*.
gi 1717019278 390 FIFYIF 395
Cdd:cd17329 347 LLLDLL 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-385 |
4.34e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.66 E-value: 4.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLTAPTLMVLRKTFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPLM 118
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 119 KIDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIA 197
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 198 VldICFILVAVPESLPEKMRPASWGApISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqYSSFFLYLRQVMEFS 277
Cdd:pfam07690 162 L--LAAVLLLLPRPPPESKRPKPAEE-ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 278 PESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SITFPAV 353
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 1717019278 354 SALVSRTADADQQGVVQGMITGIRGLCNGLGP 385
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-396 |
9.75e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 108.28 E-value: 9.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 39 AVIVIFLEFFAWGLLTAptLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 118
Cdd:cd06174 1 LLLGFFLTGLARGLISP--LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 119 -KIDAWWYFAVISV--SGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATA 195
Cdd:cd06174 79 aFAPSFWLLLLGRFllGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 196 IAVLDICFIL-VAVPESLPEKMRPaswgAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVM 274
Cdd:cd06174 159 AALALLAAILlLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 275 EFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGA-VAAMSSITFPAV 353
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1717019278 354 SALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 396
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
74-391 |
2.79e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 96.12 E-value: 2.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMKIDAWWYFAVISVsgVFAVTFSV 141
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 142 VF----AYVADITQE-HERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNL---VVVLATAIAVLDICFILVAVPeSLP 213
Cdd:COG2211 127 VNipysALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgYRLTALIFAVLGLLAFLLTFF-GTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 214 EKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSI 293
Cdd:COG2211 206 ERPVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 294 IAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF--GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ---- 366
Cdd:COG2211 279 LG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWktgr 357
|
330 340
....*....|....*....|....*...
gi 1717019278 367 ---GVVQGMITGIRGLCNGLGPALYGFI 391
Cdd:COG2211 358 rreGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-391 |
1.79e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.91 E-value: 1.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 33 SPSVYHAVIVIFLEFFAWGLLTA---PTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF 109
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 110 FTCAPIPLMKIDAWWYFAVIS--VSGV-FAVTFSVVFAYVADITQEHERSMaYGLVSATFAASLVTSPAIGAYLSREYGN 186
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 187 NLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSF 266
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 267 FLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWM-MWAAGAVAAM 345
Cdd:COG0738 234 PLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1717019278 346 SSITFPAVSALVSRTADADQQGVVqGMITGIRGLCNGLGPALYGFI 391
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
72-392 |
1.20e-18 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 87.66 E-value: 1.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 72 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFavIS-VSGVFAVTFSVVFAYVAD 148
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 149 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICfILVAVPESLPEKMRPASWGAPISWE 228
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 229 QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 308
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 309 NKNTILLGLGFQILQLAWYGF-GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 387
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
....*
gi 1717019278 388 YGFIF 392
Cdd:cd17331 353 GGALL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-392 |
9.46e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.52 E-value: 9.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIdAWWYFAVI---SVSGVF-AVTFSVVFAYVADI 149
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-APSFALLLlarALAGLAhGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 150 TQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgapisweq 229
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG--------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 230 adPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGN 309
Cdd:cd17324 187 --LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR-GGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 310 KNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-AAMSSITFPAVSALVSRTAdADQQGVVQGMITGIRGLCNGLGPALY 388
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALG 342
|
....
gi 1717019278 389 GFIF 392
Cdd:cd17324 343 GLVL 346
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
71-395 |
1.43e-17 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 84.25 E-value: 1.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 71 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLmkidawWYFA------VIS--VSGVFAVTFSVV 142
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYAL------WAVSrsftifLLSriVGGISKGNVSLS 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 143 FAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVV------LATAIAVLDICFILVAVPESLPEKM 216
Cdd:cd17389 138 TAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFfsmpalFALVLALADLLFIFFFLPETLPSNL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 217 RPASWGapisweqadpfaslkkvgqdsivllicitVFLSYLPEAG-QYSSFFLyLRQVMEFSPESVAAFIAVLGILSIIA 295
Cdd:cd17389 218 RRLGLV-----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 296 QTIVLSLLmRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMIT 374
Cdd:cd17389 268 QGGYVRRI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFR 346
|
330 340
....*....|....*....|.
gi 1717019278 375 GIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17389 347 SLGALARALGPIVACTVYWLA 367
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
41-392 |
4.12e-17 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 82.71 E-value: 4.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLTAPTLMVlrkTFPKHTFLMNGLIQGVKGLLSflsAPLIGALSDVWGRKSFLLLTVF----------- 109
Cdd:cd17386 6 PIVFLYMFASVLSGPVTQNF---VYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLVglllsslilvl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 110 ---FTCAPIPlmkidaWWYF---AVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSRE 183
Cdd:cd17386 80 ivyFTTVPSV------WWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 184 YGNNLVVVLATAIAVLDICFILVAVpeslpekmrpaswgapisweqadpfaslkkvgqdSIVLLICITVFLSYLPEAGQY 263
Cdd:cd17386 154 LGYAWSFSISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGES 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 264 SSFFLYLRQVMEFSPESVAAFIAvLGILSIIAQTIVLSLLMRSIGNKN---TILLGLGFQILQLAWYGFGSEPWMMWAAG 340
Cdd:cd17386 200 DVLYLFVLEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSdstLAMLGLASHILSSLLFAFATNTWMMYLAA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1717019278 341 AVAAMSSITFPAVSALVSRTADADQqgvvQGMITGIRGLCNGLGPALYGFIF 392
Cdd:cd17386 279 VVGMFNGIVGPMIRSILSKLVPKSE----QGKIFSLLSVLESLSPLVASPIY 326
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
74-397 |
1.01e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 81.89 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT-------VFFTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVVF-AY 145
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 146 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATaiavldICFILVAVPESLPEKMRPASWGAPI 225
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 226 SWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMR 305
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 306 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF-PAVSALVSRTADADQQGVVQGMITGIRGLCNGLG 384
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|...
gi 1717019278 385 PALYGFIFYIFHV 397
Cdd:cd06173 350 ALLAGLLADALGL 362
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
41-391 |
1.08e-16 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 81.12 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLTaPTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI 120
Cdd:cd17390 3 LVGFLDLFGVSMIL-PLLSTHIRSLGASPTVI-GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 121 DAWWYFAVIS--VSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSR-EYGNNLVVVLATAIA 197
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 198 VLDICFILVAVPESLpekmrpaswgapisweqaDPFaslkkvgqdSIVLLICITVFLSylpeagqYSSFFLYLRQVMEFS 277
Cdd:cd17390 161 ILNAGLVWFLLSKLW------------------DLL---------LVRFLMGFSVLLF-------RSNFSLYLEERFDLS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 278 PESVAAFIAVLGILSIIAQTIVLSLLmrSIGNKNTILLGLGFQILQ---LAWYGFGSEPWMMWAAGA-VAAMSSITFPAV 353
Cdd:cd17390 207 PKTIGYLISYSGVLGALSGFLVGRIL--KLYKNNEYLLLLHSFILLalsLLGLALAPSIWLLVLCLTpLSISSAVLRTCS 284
|
330 340 350
....*....|....*....|....*....|....*...
gi 1717019278 354 SALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 391
Cdd:cd17390 285 TSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLL 322
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-208 |
7.73e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.91 E-value: 7.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLtAPTLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI 120
Cdd:cd17325 206 LAIFVLAFAFGAL-EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 121 --DAWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIA 197
Cdd:cd17325 285 atSFWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALL 364
|
170
....*....|.
gi 1717019278 198 VLDICFILVAV 208
Cdd:cd17325 365 LLAAVLFLLLR 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-395 |
7.82e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.55 E-value: 7.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 40 VIVIFLEFFAWGLLTaPTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 119
Cdd:cd17489 2 LLANFFFFLSFYLLL-PVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 120 I--DAWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAI 196
Cdd:cd17489 80 LatSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 197 AVLDI--CFILVAVPESLPEKMRPASWGapisweqadPFASLKKVgqdsiVLLICITVFLSYLPEAGqySSFFLYLrQVM 274
Cdd:cd17489 160 ALLALllVFLVKDPPPVAAEEAEAGTRA---------FRRLVEKK-----VLPPALILFLASIAYGA--ISTFLPL-YAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 275 EFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAV 353
Cdd:cd17489 223 ERGISNAGLFFTVYAIALLLSRPFSGKLSDR-KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPAL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1717019278 354 SALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17489 302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-392 |
8.87e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 69.91 E-value: 8.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 39 AVIVIFLEFFAWGLLtAPTLMVLRKTF---PKHTFLMNGLIqgvkGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAP 114
Cdd:COG2223 10 ATLAFFLAFGVWYLW-SVLAPPLAEEFglsAAQLGLLFAIP----VLVGALLRIPLGFLVDRFGpRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 115 IPLMKIDAWWYFAVISV-SGVFA-VTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYG-NNLVVV 191
Cdd:COG2223 85 LLLALAVSYWLLLLLGLlLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 192 LATAIAVLDICFILVAvpESLPEKMRPASwgapisweqADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLR 271
Cdd:COG2223 165 LGILLLVVAVLAWLFL--RDPPAGAAAAA---------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 272 QVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAW--YGFGSEPWMMWAAGAVAAMSSIT 349
Cdd:COG2223 234 DQFGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1717019278 350 FPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 392
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
86-397 |
1.02e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.53 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 86 LSAPLIGALSDVWGRKSFLLLTVFFTCAPIPL--MKIDAWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVS 163
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLaaFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 164 ATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLpekMRPASWGAPIsweqadpfaslkkvgqds 243
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRLL---RRRNVLLANI------------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 244 IVLLICITVFLSY--LPEAGQYSSFFLYLRQVMEfspesvAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI 321
Cdd:cd17504 185 TALLAGFGMFMVFqlLPQLLQLPTPTGFGLGITE------AGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1717019278 322 LQLAWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHV 397
Cdd:cd17504 259 VGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
82-392 |
1.11e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.22 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 82 LLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF--AVTFSVVFAYVADITQEHERSM 157
Cdd:cd17355 49 LAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALatSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERRRGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 158 AYGLVSATFAASLVTSPAIGAYLSREYG-NNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGAPisweqADPFASL 236
Cdd:cd17355 129 ALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP-----ASPGSTL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 237 KKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQvMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLG 316
Cdd:cd17355 204 KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLLAAS 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1717019278 317 LGFQILQLAWYGFGSEP-WMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 392
Cdd:cd17355 282 YALRALGLALLLLLPFPpLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
35-396 |
1.54e-12 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 69.03 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 35 SVYHAVIVIFL------EFFAWGLLTAPTLMVlrktfpkhtflmnGLIQGVKGLLSFLSAPLIGALSDVWGRK-----SF 103
Cdd:COG2270 23 SAFSTVITTFVfppyftSVAALGDPAAATALW-------------GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 104 LLLTVFFTCApIPLMKIDAWWYFAVISVSGVFAVTFSVVF--AYVADITQEHER--------SMAY--GLVSATFAASLV 171
Cdd:COG2270 90 TLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFLPDIATPEEIgrvsglgwALGYlgGVLLLLINLALF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 172 TSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGAPISWEQAdpFASLKKVGQDSIVL--LIC 249
Cdd:COG2270 169 LKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRAGFREL--RRTLRELRRYRDLLrfLLA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 250 ITVFLSYLpeAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF 329
Cdd:COG2270 247 YFFYRDGV--QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALG-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYF 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019278 330 GSEPWMMWAAGAVAAMSSITFPAVS-ALVSRTADADQQGV------VQGMITGIrglcngLGPALYGFIFYIFH 396
Cdd:COG2270 324 LTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEffglyaLSGKAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-374 |
1.80e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 51 GLLTAPTLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAV 128
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIagLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 129 ISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSrEYGNNLvVVLATAIAVldICFILVA 207
Cdd:cd17473 95 RALLGIGvAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRA-PFLVYLLAL--PVLILVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 208 VpeSLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAV 287
Cdd:cd17473 171 L--FLPEPARKSK-------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 288 LGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ 366
Cdd:cd17473 242 ASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELR 320
|
....*...
gi 1717019278 367 GVVQGMIT 374
Cdd:cd17473 321 GRAMGIVT 328
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
74-396 |
3.22e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.97 E-value: 3.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADIT 150
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 151 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdicfilvavpeslpekmrpasWGAPISWeqa 230
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL---------------------LALLRFW--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 231 dpfaslkkvgqdsivlLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIG-- 308
Cdd:COG2271 184 ----------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrr 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 309 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 387
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL 326
|
....*....
gi 1717019278 388 YGFIFYIFH 396
Cdd:COG2271 327 VGYLLDATG 335
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
74-391 |
6.20e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 66.84 E-value: 6.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-----TVFFTCAPIPLMKIdAWWYFAVISVSGVF-AVTFSVVFAYVA 147
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLlsllaAVLFFLSLFFVAQI-FWLLLLLVILGAFFsAPVVPLVDSITL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 148 DITQEHERSmaYGLV----SATFAAslvTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVpeslpeKMRPASWGA 223
Cdd:cd17335 114 QYLGEERER--YGKQrlwgSIGFGI---AALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLAL------KFPFRPKHP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 224 PISWEQADPFASLKKVGqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQVMefSPESVAAFIAVLGILSIIAQTIVLSLL 303
Cdd:cd17335 183 EPNENTGGLLALLRNPR----VLAFLLVAFLMGFGHGLIYSFLFWHLQDLG--GSKTLIGLLWTVGVVSEIPFFFFSSRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 304 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV----SALVSRTADADQQGVVQGMITgirGL 379
Cdd:cd17335 257 IQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGLLQ---GL 330
|
330
....*....|..
gi 1717019278 380 CNGLGPALYGFI 391
Cdd:cd17335 331 YFGLGGGLGSLI 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
86-395 |
2.37e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 65.28 E-value: 2.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 86 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLV 162
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLpgLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLY 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 163 SATFAASLVTSPAIGAYLSrEYGNNLVVVLATAIAVLDICFILVAVPESlPEKMRPASWGAPISWEQADPFASLKKVGQD 242
Cdd:cd17474 129 EAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEP-KEKAKSSSATKLRDLKKALRGRGLLTFLVS 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 243 SIVLLICITVFLSYLPeagqyssffLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQIL 322
Cdd:cd17474 207 AFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYAL 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019278 323 QLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
90-392 |
1.75e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.59 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 90 LIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATF 166
Cdd:cd17320 53 LYGPLSDRFGRRPVLLagLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 167 AASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdiCFILVA--VPESLPEKMRPASWGApisweqadPFASLKKVGQDSI 244
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLL--LLLLVLlfLPETLPEEKRKPLLSS--------LLRAYKRVLKNRR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 245 VLL------ICITVFLSYLPEAGqyssfFLYLrQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLG 318
Cdd:cd17320 203 FLGyalalgLSFAGLFAYLAAAP-----FIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 319 FQI------LQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRtADADQQGVVQGMITGIRGLCNGLGPALYGFIF 392
Cdd:cd17320 276 LLLaaalvlLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-398 |
2.34e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 62.18 E-value: 2.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKIDAWWYFAVISVS------GVFAvtfSVVFAYV 146
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 147 ADITQEHERSMAYGLVSA--TFAAslVTSPAIGAYLSREYGNN--LVVVLATAIAVLDICFILVAVPESlPEKMRPaswg 222
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGA--VLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEY-PRPPKL---- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 223 apiswEQADPFASLKKVGQDSIVLLICITVFlsylpEAGQYS-SFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLS 301
Cdd:cd17370 187 -----RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 302 LLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLC 380
Cdd:cd17370 256 RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335
|
330
....*....|....*...
gi 1717019278 381 NGLGPALYGFIFYIFHVE 398
Cdd:cd17370 336 WLLASLIAGYLWDLISPS 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
89-393 |
4.47e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.42 E-value: 4.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 89 PLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSAT 165
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLigLALFGLASLLCALAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 166 FAASLVTSPAIGAYLSREYGNNLVVVLATAIAVldICFILVavpeslpekmrPASWGApisweqadpfaslkkvgqdsiv 245
Cdd:cd17321 129 VGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA-----------RTFSGA---------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 246 lliCITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLA 325
Cdd:cd17321 174 ---VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1717019278 326 WYGFGSEPWMMWAAGAVAAMSSI----TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 393
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
53-392 |
5.20e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 58.00 E-value: 5.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 53 LTAPTLMVLRKTFPKHTFLMNGLIQGVKGLL-SFLSAPLiGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVI 129
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILfgLLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 130 SVSGVFAVTfSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVP 209
Cdd:cd17472 93 ALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 210 ESLPEKMRPASWGapisweqadpfASLKKVGQDSIVLLICITVFLSYLpeagQYSSFFLYLRQVME------------FS 277
Cdd:cd17472 172 DPPKIVQISEKEK-----------KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFYILPLLLTqlgggkgqlwkvYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 278 PESVAAFIAVlGILSIIAQ--TIVLSLLMRSIgnkntILLGLGFQILqlawyGFGSEPWMMWAAGAVAAMSSITF--PAV 353
Cdd:cd17472 237 PAILIGFILM-VPFVIYAEkkGKMKQVFVSSI-----LLIAVGFLLL-----LFAATSLWLLIIGLIIFFIGFNLleALL 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 1717019278 354 SALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 392
Cdd:cd17472 306 PSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
74-395 |
7.96e-09 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 57.25 E-value: 7.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRK-------SFLLLTVFFTCAPIPLMKIdAWWYFAVISV-----SGVFAVTFSV 141
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKRkavvrlaSILAAVLFLSVLFIPISLT-FWWLALLVVLfsffwNAILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 142 VFAYVADITQEHERSMAYGLVSatFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDicfilVAVPESLPEKMRPASW 221
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVG--FALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLS-----LLLPLAPPEMEYESKG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 222 GapisweqadPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVmEFSPESVAAFIAVlGILSIIAQTIVLS 301
Cdd:pfam12832 189 G---------SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENL-GASNTLLGALWAL-GVVAEIPLFFYAH 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 302 LLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWmmWAAGAVAAMSSITFPAVSA----LVSRTADADQQGVVQGMITGIR 377
Cdd:pfam12832 258 RLLRRFGHRNLLIIALLLTALRWLLYAFFVENP--WLVLPIQFLHAISFGLTHAaaieYVRRIFPGSLQGTGQALYSGLY 335
|
330
....*....|....*....
gi 1717019278 378 -GLCNGLGPALYGFIFYIF 395
Cdd:pfam12832 336 fGLGGALGSLIGGQLWDLF 354
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
86-392 |
2.86e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 55.69 E-value: 2.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 86 LSAPLIGALSDV----WG-RKSFLLLT----VFFTCA----PIPLMKIDAWWYFAVISVSGVFAVTFSVVF-AYVADITQ 151
Cdd:cd17332 50 INDPLMGYLIDRtrsrWGrFRPWLLWGaiplALLFVLlfttPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 152 E-HERS--MAYGLVSATFAASLVTS--PAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESlpEKMRPASWGAPIS 226
Cdd:cd17332 130 DpEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT--RERVVPPEEEKSK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 227 WEQADPFASLKKvgQDSIVLLICITVFLSYLPEAGQySSFFLYLRQVMEFSPESVAAFIAVLGILSIIaqTIVLSLLMRS 306
Cdd:cd17332 208 LPLLKSLKALLK--NRPFLILLLAYLLYFLAFNIVN-TVLVYYFKYVLGGRAELVLLLLLILSGALLA--LLPWPPLKKR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 307 IGNKNTILLGLGFQILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAVSALVSRTADADQ--QGV-VQGMITGIRGLC 380
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362
|
330
....*....|..
gi 1717019278 381 NGLGPALYGFIF 392
Cdd:cd17332 363 RKLGLALAGALV 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-210 |
7.95e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 7.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 39 AVIVIFLEFFAWGLLT-APTLMVLRKTFPKHTFlmnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPL 117
Cdd:COG2271 186 ALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQA---GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALAL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 118 MKI----DAWWYFAVISVSGVFA-VTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVL 192
Cdd:COG2271 263 LLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
|
170
....*....|....*...
gi 1717019278 193 ATAIAVLDICFILVAVPE 210
Cdd:COG2271 343 LAALALLAALLALLLLRE 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-199 |
1.31e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.70 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 17 AKKIVIKDGGTSQGIGSPSVYHAVIVIFLefFAWGLLTAPTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSD 96
Cdd:cd17370 183 PPKLRKKSKKTSLKKLPKAFWLYLLAVAL--FALGNFSFAFLILRAQELGLSAALI-PLLYALFNLVYALAAYPAGRLSD 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 97 VWGRKSFLLLT-VFFTCAPIPLM-KIDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTS 173
Cdd:cd17370 260 RIGRKKLLILGyLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLA 339
|
170 180
....*....|....*....|....*.
gi 1717019278 174 PAIGAYLSREYGNNLVVVLATAIAVL 199
Cdd:cd17370 340 SLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-308 |
3.62e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.74 E-value: 3.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 39 AVIVIFLEFFAWGLLtAPTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 118
Cdd:COG0477 19 LALGTFLEGLDFTIV-NVALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 119 KI--DAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATA 195
Cdd:COG0477 97 GLapSPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 196 IAVLDIcFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVME 275
Cdd:COG0477 177 LGLLAL-VLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|...
gi 1717019278 276 FSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 308
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
244-396 |
7.86e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 7.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 244 IVLLICITVFLSYLpEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 323
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019278 324 LAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 396
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
89-396 |
1.12e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 50.77 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 89 PLIGALSD----VWGR-KSFLLL---------TVFFTCAPIPLMKIDAWWYFAVISVSgvFAVTFSVV--FAYVADITQE 152
Cdd:pfam13347 51 PIVGHIIDrtrtRWGRrRPWLLLsaiilavsfILLFTPPELGRAPLFIWLLATYILLR--IAYTFFEIpyWSLGPELTRD 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 153 -HERS---------MAYGLVSATFAASLVTSPaIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWG 222
Cdd:pfam13347 129 yDERTsltsyrsffSVGGGLLAAALAFPLVLI-LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 223 ApiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFspESVAAFIAVLGILSIIAQTIVLSL 302
Cdd:pfam13347 208 K----EAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN--GFAASAFPLVFTIGALLGIPLWPP 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 303 LMRSIGNKNTILLGLGFQI--LQLAWYGFGSEPWMMWAAGAVAAMSSIT-FPAVSALVSRTADADQ---QGVVQGMITGI 376
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIGFGYGSsFFLPWSMLADVVDYGElrtGKRREGTFFAM 361
|
330 340
....*....|....*....|....
gi 1717019278 377 RGLCN----GLGPALYGFIFYIFH 396
Cdd:pfam13347 362 WSFISklatGVGLGVSGLLLSAFG 385
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
74-220 |
1.81e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.88 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFftCAPIPLMKIDAWWYFAVISVSGVFA-VTFSVVFAYVA 147
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRrvlliVFALMALG--LLLLALALGSLWLFLVLFLLLGLALgGGNGAVFALVP 321
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1717019278 148 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLsREYGNNLVVVLATAIAVLDICFILVAVpesLPEKMRPAS 220
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL-LDATGSYTAAFLVFAVLALVALVLTLL---LYRRPRRAA 390
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
72-395 |
5.15e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 5.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 72 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFA---VTFSVVFAy 145
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILfpSPWGLLIARFLSGIAAatwVSFTVLYA- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 146 vaDITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWgapi 225
Cdd:cd17490 111 --SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTEL---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 226 sweqadpfASLKKVGQDSIVLlicitvFLSYLPEAGQYSSFflylRQVMEFSP---ESVAAFIAVLGILS-------IIA 295
Cdd:cd17490 185 --------KELLSVLKDKKLL------FFSLLAILQQMITF----STTFGFTPliaKQLGASSFQLGLLSiiyllpnALA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 296 QTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMIT 374
Cdd:cd17490 247 SLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQ 326
|
330 340
....*....|....*....|.
gi 1717019278 375 GIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17490 327 AIYALGMFLGPVLVGIISEAF 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
248-395 |
5.62e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 5.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 248 ICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWY 327
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1717019278 328 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 395
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
74-391 |
7.93e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 7.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYVADITQ 151
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFvtNVWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 152 EHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIavLDICFILVAVpeSLPEKMRPASWGAPISWEQAd 231
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGL--LFLAFLLTLF--FVKEDFKPVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 232 pfasLKKVGQDSIVLLICITVFLSylpeagQYSSFF------LYLRQVMefSPESVAAFIA-----VLGILSIIAqTIVL 300
Cdd:cd17391 194 ----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLM--GDASNLAFISglvfsATGVSSLLS-APRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 301 SLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPW-MMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGL 379
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
330
....*....|..
gi 1717019278 380 CNGLGPALYGFI 391
Cdd:cd17391 341 GNVAGPLLGSAI 352
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
90-336 |
1.24e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 90 LIGALSDVWG-RKSFLLLT-VFFTCAPIPLMKIDAWWYFAVISV--SGVFAVTFSVVFAYVADITQEH---ERSMAYGLV 162
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLAlLAGALGYLLFAFLRNYWVLLLVGVvlLSLGAAAFPQLFALAREYADRSsgrDATLFNSVL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 163 SATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdicfILVAVPESLPEKMRPAswgapiswEQADPFASLKKVGQD 242
Cdd:cd17471 131 RAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLV----VALLVLFLLPSVKPPA--------QKATPASSLVKAPVN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 243 SIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFsPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQIL 322
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGG-SESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVL 277
|
250
....*....|....
gi 1717019278 323 QLAWYGFGSEPWMM 336
Cdd:cd17471 278 FYLGLALATSLWQL 291
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-350 |
1.81e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.78 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 43 IFLEFFAWGLLTapTLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLM-KI 120
Cdd:cd17477 5 VALLGLGSGLLL--PLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVLLLAlTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 121 DAWWYFAVISVSGVFAVTFSVVF-AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSreygnnlvVVLATAIAVL 199
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG--------TAGALPFLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 200 DICFILVAVPESLpekmrpaSWGAPISWEQADPFASLKKVgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMeFSPE 279
Cdd:cd17477 155 AVLLLLALVPLLL-------TRRAAPEIEEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVA 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1717019278 280 SVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 350
Cdd:cd17477 224 QAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
39-199 |
1.85e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 39 AVIVIFLEFFAWGLLT-APTLMVLRKTFPKHTFLMNGLIQGvkgLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIP 116
Cdd:cd17316 183 ILLWFFISFGYYGLTTfLPTYLQTVLGLSPATSSLYLLLIS---LGALVGALIAGLLSDRIGRKKTLVIGlILSGILALP 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 117 LMKI---DAWWYFAVISVSGVFAVTFSVVF-AYVADITQEHERSMAYGLVSAT-FAASLVTSPAIGAYLSREYGNNLVVV 191
Cdd:cd17316 260 LFYLlsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPAL 339
|
....*...
gi 1717019278 192 LATAIAVL 199
Cdd:cd17316 340 ILALLAIV 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
74-392 |
1.95e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.79 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGV-FAVTFSVVFAYVADIT 150
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLapSVALLLAGTALIGAgIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 151 QEHeRSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESlpekmRPASWGAPISWeqa 230
Cdd:COG2807 136 PDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-----PAAAAAAPAAA--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 231 dpfaSLKKVGQDSIVLLICITVFLSylpeAGQYSSFFLYLRQVME---FSPESVAAFIAVLGILSIIAQTIVLSLLMRSI 307
Cdd:COG2807 207 ----SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVAWLPPILRdagLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 308 GNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVS-RTADADQQGVVQGMITGIRGLCNGLGPA 386
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPL 358
|
....*.
gi 1717019278 387 LYGFIF 392
Cdd:COG2807 359 LVGALH 364
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
78-205 |
2.39e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.45 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 78 GVKGLLSFLSAPLIGALSDVWGRK---SFLLLTVFFTCAPIPLMKIDAWWYFAVISVSGV-FAVTFSVVFAYVADITQEH 153
Cdd:cd17353 256 SILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTK 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1717019278 154 ERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFIL 205
Cdd:cd17353 336 NAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
244-395 |
2.93e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 244 IVLLICITVFLSYLPEAGqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 323
Cdd:COG2271 11 ILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1717019278 324 LAWYGFGSEPWMMWAA-GAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 395
Cdd:COG2271 89 TLLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
74-346 |
1.02e-04 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 44.52 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCAPIpLMKIDAWWYFAVISVSGVFAVTFSVVF--AYV 146
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTALLF-FVTPGQWLLALLLFILANIGFSGANVFydAFL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 147 ADITQEHER----SMAYGLvsATFAASLVTSPAIGAYLSREYGNnlvvvLATAIAVlDICFILVAVpeslpekmrpasWG 222
Cdd:cd17482 121 PDVASPERMdrvsSLGYAL--GYIGGGLLFAVNLVLILGPDAFG-----LDTAEAV-RLSFLSVAL------------WW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 223 APISweqadpfASLKKVGQDSIVLLICI----TVFLSylpeAGQYSSfflylrQVMEFSPESVAAFIAVLGILSIIAqTI 298
Cdd:cd17482 181 ALFS-------IPLKQLLLFLIAYFFYIdgvqTIIRM----ATIYGA------EEGKLGSSALILALLLTQFVAFPG-AL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1717019278 299 VLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS 346
Cdd:cd17482 243 LFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLV 290
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
82-349 |
1.35e-04 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 44.03 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 82 LLSFLSaPLIGALSDVWGRKSF----------LLLTVFFTCAP--IPLMKIDAWW--YFAVISVSGVFAVTFSVV----F 143
Cdd:cd06176 47 LVAPLR-VWIGHRSDTHPLRGYrrtpyiwlgmLLLALGLALAPfaALLLAGAAFWlgLALAVLAFLLYGIGVGAAgtafL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 144 AYVADITQEHERSMAYGLV-SATFAASLVTSPAIGAYLsREYGNNLVVVLATAIAVLDICFILVAVPESlpEKMRPASWG 222
Cdd:cd06176 126 ALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLL-DPYSPERLIQVFQIVALVALLLALLALWGV--ERRRSRAAL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 223 APISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqysSFFL-------YLRQVMEFSPESVAAFIAVLGILSIIA 295
Cdd:cd06176 203 AAEEAPPETFREALRLLWASPQARRFFIFLFLSTL-------ALFMqdvilepFGGEVFGMSVGETTRLTAIWGGGTLLG 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 296 QTIVLSLLMRSIGNKNTILLGLGFQILQ---LAWYGFGSEPWM-------------MWAAGAVAAMSSIT 349
Cdd:cd06176 276 MLLAGFLLSRRLGKKRTAALGCLLSALGfllLALAGLLGNPWLfrpgvfllglgngLFTVGALTLMMDLT 345
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
41-392 |
1.51e-04 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 43.99 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLTAPTLMVLRKTFpkHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-- 118
Cdd:pfam03825 9 VMMFLQFFIWGAWLVTLGSYMFVTG--FDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGAITLFMaa 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 119 -KIDAWWYFAVISVSGV-----FAVTFSVVFAYVADITQEHERSMAYGLVsATFAASLVTSPAIGAYLSREYGNnlVVVL 192
Cdd:pfam03825 87 qVTTFEAFFLVILVNSLaymptLALTNSIAFANLQDPVTDFPPIRVWGTI-GWIMASWPFVMWVVSLAGFELSH--MQLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 193 ATAIAvldiCFILVAVPESLPEKmrPASWGAPISWEQA---DPFASLKkvgqDSIVLLICITVFLSYLPEAGQYSSFFLY 269
Cdd:pfam03825 164 IAAGL----SALLVLFALTLPHT--PAKQKANQSWTTLlglDAFALLK----NKRMAVFFIFSFLLGAELQIYNVFANTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 270 LRQVMEFSPESvAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS--- 346
Cdd:pfam03825 234 LTSFDKFIVKH-ASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGADPTPFGTALLLLSMIvhg 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1717019278 347 ---SITFPAVSALVSRTADADQQGVVQGMITgirGLCNGLGPALYGFIF 392
Cdd:pfam03825 313 vayDFFNITGYIFVDKEVPPAIRASAQGLFL---LMTNGFGCILGSILS 358
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
39-391 |
1.55e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 39 AVIVIFLEFFAWGLLTApTLMVLRKTFPKH-TFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPL 117
Cdd:cd17316 4 AGLGWFFDAYDFFLIGF-VAPVLAAEFSLGlSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 118 MKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSpaigaylsreygnNLVVVLAT 194
Cdd:cd17316 83 IGLlpTPILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA-------------ALVASLLI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 195 AIAVLD----ICFILVAVPESLPEKMRPASWGAPISWeqadpfaslkkvgqdsIVLLICITVFLSYLPEagqyssfflYL 270
Cdd:cd17316 150 PLLSGDwgwrILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLPT---------YL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 271 RQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF---GSEPWMMWAAGAVAAMSS 347
Cdd:cd17316 205 QTVLGLSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllsGSPTLLLLLLFILSFFVG 283
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1717019278 348 ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 391
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
71-390 |
1.69e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.76 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 71 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYVAD 148
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLaqNIWQFLILRALLGLLGGFVPNANALIAT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 149 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGnnLVVVLATAIAVLDICFILVAVpeSLPEKMRPASWGAPISWE 228
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG--LRPVFFITASVLFLCFLVTLF--CIRENFQPVSKKEMLHMR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 229 QAdpFASLKkvgQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMefSPESVAAFI-----AVLGILSIIAQTiVLSLL 303
Cdd:PRK09874 210 EV--VTSLK---NPKLVLSLFVTTLIIQVATGSIAPILTLYVRELA--GNVSNIAFIsgmiaSVPGVAALLSAP-RLGKL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 304 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAG-AVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNG 382
Cdd:PRK09874 282 GDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRfLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNV 361
|
330
....*....|....*
gi 1717019278 383 LGP-------ALYGF 390
Cdd:PRK09874 362 TGPlmgaaisANYGF 376
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
69-398 |
3.47e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 69 TFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYV 146
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWLLLLLVALAGIGSAAFHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 147 ADITQEHERSMAYGLVSA--TFAASLvtSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKmrpasWGAP 224
Cdd:cd17478 109 ASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA-----KKAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 225 ISWEQADPFASLKKVgqdsiVLLICITVFLSYLPEAGqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLM 304
Cdd:cd17478 182 AKSSARSTLKGVWRA-----LLLLLIIVFLRSWVLSS-LTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG-TLIGGPLS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 305 RSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTAdADQQGVVQGMITGIRGLCNGLG 384
Cdd:cd17478 255 DRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIG 333
|
330
....*....|....
gi 1717019278 385 PALYGFIFYIFHVE 398
Cdd:cd17478 334 APVLGALADAFGLE 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
82-397 |
3.73e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.55 E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 82 LLSFLSAPLIGALSDVWGRKSFLLL-TVFFT-----CAPIPLMkidaWWYFAVISVSGVFA-VTFSVVFAYVADITQEHE 154
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIaIVIFElgsllCGLAPNM----TMLIVGRAIQGIGGgGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 155 RSMAYGLVSATFAASLVTSPAIGAYLSREYGN------NLVVVLATAIAVLDICFILVAvpeslpekmrpaswgapiswe 228
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWrwcfyiNLPIGGLALALLRTILLSSIF--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 229 qadpfaslkkvgqdSIVLLICITVFLSYLPeagqyssffLYLRQVMEFSPeSVAAFIAVLGILSIIAQTIVLSLLMRSIG 308
Cdd:cd17502 176 --------------GFLFGGALFGLIYYLP---------LYFQLVLGDSA-TKSGVRLLPLIIGLVIGSIISGALISKTG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 309 N-KNTILLGLGFQI---LQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVqgmiTGIRGLCNGL 383
Cdd:cd17502 232 RyKPLIVIGTILMSvgaGLLTTLTLDTSKWLLIGYLILLGLGLgIGFQQPLVAVQNAVPPADVGVA----TATNTFFRSL 307
|
330
....*....|....
gi 1717019278 384 GPALYGFIFYIFHV 397
Cdd:cd17502 308 GGTLGVAITDVFLV 321
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
74-376 |
5.86e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDV----WG-RKSFLLLTVFFTC---APIPLMKIDAWWYFAVISVSGVFAVTFSVVF-- 143
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAAlglILIPNAADIGLALGDGPRTWALVLFVLGIVLld 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 144 -----------AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLS------REYGNNLVVVLATAIAVLDICFI-- 204
Cdd:cd17313 117 famnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWdhnwfgFALGGNLKVPFYIGAIILLVCVLvt 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 205 LVAVPEslpEKMRPASWGAPISWEQADPFASLKKV--GQDSIVLLICITVFLSYLpeAGQYSSFF--LYLRQVMEFSP-- 278
Cdd:cd17313 197 LFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFFWWI--AFFPFELFftDYMGEEVYHGTsa 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 279 --------ESVAAFIavLGILSIIAQ--TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI 348
Cdd:cd17313 272 asshygagVRMGAWG--LLIFSLAFLifSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349
|
330 340
....*....|....*....|....*....
gi 1717019278 349 TFPAVS-ALVSRTADADQQGvvQGMITGI 376
Cdd:cd17313 350 TININPyPLVSDYHSESGRG--QGTDTGL 376
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
77-322 |
6.60e-04 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 41.83 E-value: 6.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 77 QGVKGLLSFLSA--PLIGALSDVWG-----RKSFLLLTVFFTCAP---IPLMKIDAWWYFAVISVSGVFAVTFSVVF--A 144
Cdd:cd17484 36 QALTSIASLPWAikPLYGLLSDSVPifgyrRKPYLILAGALGALSwlaLALVSNSSLALALLLLLLASLGVAFSDVVidA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 145 YVADITQEHERSMAYGLVSATFAASlvtspAIGAYLSREYGNNLV--VVLATAIAVLDICFILVAVPESLpeKMRPASWG 222
Cdd:cd17484 116 LVVEASRGAPQSLAGDLQSLCWGSS-----AIGGIVGSYFSGYLLelLGPRTVFAVTSFFPLLLLIVAFF--VKEERVPP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 223 APISWEQADPFASLKKVGQDSIVLLICITVFLSY-LPEAGqySSFFLYLRQVMEFSPESVaAFIAVLGILSIIAQTIVLS 301
Cdd:cd17484 189 HRTKENFDEQLKALWETVKQPSIWLPALFIFLYQaTPSSG--SAMFYFMTNELGFSPEFL-GRLRVIGSIASLLGVLLYN 265
|
250 260
....*....|....*....|.
gi 1717019278 302 LLMRSIGNKNTILLGLGFQIL 322
Cdd:cd17484 266 RFLKHVPFRKIFFWTTVLLVL 286
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
69-395 |
9.37e-04 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 41.53 E-value: 9.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 69 TFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDawwYFAVISVSGVFAVTFSVVFAYVAD 148
Cdd:cd17479 29 TAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLLYHQ---IFLLVLLVIIIWELLSAPLEKVAD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 149 -----------ITQEHERSMAYGLVSATFAASLVT----------SPAIGAYLSREYGNNLVVVLATAIAVLdicfilva 207
Cdd:cd17479 106 dslyeyldfvdATERYGKLKVWSALGAAFGPCGITllvdnldcflPPKISRILLHFYTYGGFMILTFLLSFF-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 208 VPESLPEKMRPASWGapisweqadpFASLKKVGQDSIVLLICITVFLSYLPeAGQYSSFFLYLRQVMEFSPESVAAFIAV 287
Cdd:cd17479 178 YPIPVPKKEEHSSKV----------VKGLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 288 lGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPA---------VSALVS 358
Cdd:cd17479 247 -ALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWavnsqveflASPGME 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 1717019278 359 RTADAdqqgVVQGMitgIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17479 326 RSLQL----VLRAL---YYGIGFALGSFVSGFIYDRF 355
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
74-391 |
1.01e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.47 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDAWWYFAVIS--VSGVFAVTFSVVF-AYVADIT 150
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALAlfLFGAANGALDVAMnAQGVAVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 151 QEHER---SMAYGLVSA-TFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEkmRPASWGAPIS 226
Cdd:cd17393 117 RAYGRpimSSLHAMWSLgGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAED--RPDGAGKPGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 227 weqadpfaslkkVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRS 306
Cdd:cd17393 195 ------------LLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGR-LFGDRLVDR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 307 IGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-----AAMSSITFPAVSALVSRTADAdqqGVVQGMITGIRGLCn 381
Cdd:cd17393 262 FGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALmglglSVVVPLAFSAAGALPGLAAGI---AVARVATLGYLGFL- 337
|
330
....*....|
gi 1717019278 382 gLGPALYGFI 391
Cdd:cd17393 338 -VGPPLIGFL 346
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
40-205 |
1.63e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 40 VIVIFLEFFAWGLLTAPTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSD-VWGRKSFLLLTVF---FTCAPI 115
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLlmaLGLALL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 116 PLMKIDAWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSAT-FAASLVTSPAIGAYLSREYGNNLVVVLAT 194
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFgFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
170
....*....|.
gi 1717019278 195 AIAVLDICFIL 205
Cdd:cd06174 368 VLLLLAAILLL 378
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
41-208 |
2.11e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.47 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 41 IVIFLEFFAWGLLTAPTLMVLRKTFPKHTFLMNGLIqGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF------TCAP 114
Cdd:cd17314 213 IAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLM-SIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTilglglCAFL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 115 IPLMKIDaWWYFAVISVSG-VFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLA 193
Cdd:cd17314 292 FLLKMTP-VGLVLTGSLLGfSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYI 370
|
170
....*....|....*
gi 1717019278 194 TAIAVLDICFILVAV 208
Cdd:cd17314 371 YAVIVFLASAILLAV 385
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
82-391 |
2.94e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 39.79 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 82 LLSFLSAPLIGALSDVWGRKSFLLLtvfftcaPIPLMKIDAWWYFAVIS----------------VSGVFAVTFSVVFAY 145
Cdd:cd17449 76 LVGLFSVTLLGPWSDSVGRRPVLIL-------PSLGLALQAAVYLLVMYlqlhvayfligrilsgLLGDFNGILAGCFAY 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 146 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSRE--YGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGA 223
Cdd:cd17449 149 VADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAqgYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRH 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 224 PISWEQ----ADPFASLKKVGQDSIVLLICITVFLsylpeaGQYSSFFLY-LRQVMEFSPE-----SVAAFIAVLGILsi 293
Cdd:cd17449 229 HQSVVRlyvaPAPNGSRRKLALYSLALFVVVTVHF------GAKDLLVLYeLSSPLCWDSDligygSAAEHLTYLSSL-- 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 294 iaqtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMI 373
Cdd:cd17449 301 ----LGLRLLQLCLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASV 376
|
330 340
....*....|....*....|....*.
gi 1717019278 374 TGIRGLC--------NGLGPALYGFI 391
Cdd:cd17449 377 ACVEGLCslvatgifNSLYPATLHFM 402
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
90-360 |
3.05e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 39.67 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 90 LIGALSDVWGRKSFLLLTVF-FTCAPIPLMKIDAWWYFAVIS-VSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATF 166
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFiFALSSLGLALSNNIETLLVLRfVQAFGASAGSVIsQALVRDIYPGEELSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 167 AASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgaPISWEQ-ADPFASlKKVGQDSIV 245
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQI---STYFETfLLLLKS-KMFWGYALI 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 246 LLICITVFLSYLPEAGqyssfFLYLRQvMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLA 325
Cdd:TIGR00710 215 YGASFGGFFAFFSGAP-----FVYIDI-MGVSPSVFGLLFALNIIAMIFG-GFLNGRFIKKWGAKSLLRMGLILFAVSAV 287
|
250 260 270
....*....|....*....|....*....|....*...
gi 1717019278 326 WYGFGsepwMMWAAGAVAAMSSITF---PAVSALVSRT 360
Cdd:TIGR00710 288 LLEIT----AILGLGSWAMIIGPMMfvgIGNSMISSIA 321
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
90-330 |
3.70e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 3.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 90 LIGALSDVWGRKSFLLLTV----FFTCApipLMKIDAWWYFAVI-SVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVS 163
Cdd:cd17371 53 LGGILADRFGRVRVLVITIllfaVFTLL---CGFAQNYWQLLILrALAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 164 ATFA-----ASLVTSPAIGaYLSREYGNNLVVVLAtAIAVLDICFILVAVPEslpekmrPASWGAPISWEQADPFASLKK 238
Cdd:cd17371 130 SGWAvgwllATLLAALLFP-LLPPEIAWRVLFLLG-ALPALLVLFIRRFVKE-------PPQWQAARAARRHFADRPSLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 239 VGQDSIVLLICI-TVFLSYLPEAGQYS-SFFL--YLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTIL 314
Cdd:cd17371 201 ELFSPPLLRTTLlASLLATGALGGYYGiTTWLpsYLTGERGLSFEGSAGYLVVTILGGFLG-YLAGGFLADRIGRRNNFA 279
|
250
....*....|....*.
gi 1717019278 315 LGLGFQILQLAWYGFG 330
Cdd:cd17371 280 LFALGSAISILLYFFL 295
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
74-395 |
4.40e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 39.50 E-value: 4.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-----KIDAWW-YFAVIS--VSGVFAVTFSVVFAY 145
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILyalaeYFPSNRkYVMLVArfLIGVGAGNVAVLRAY 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 146 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLS------REYGNNLVVVLATAIAVLDICFILVAVpeslpekmrpa 219
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTpigypgYVIGIKLRFNMYTAPAWLMAILGIINI----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 220 swgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLY------LRQVM-----EFSPESVAAFIAVL 288
Cdd:cd17326 188 ------------------------ILILFFFKEVVCIFLFFVVLFIFANLetigtpLTMDMygwtrEEAVLYNGIILAVS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 289 GILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYgfgsepwMMWAAGAVAAMsSITFPAVS----ALVSRTADAD 364
Cdd:cd17326 244 GVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILF-GLGYPIGNvmlyTLYSKILGPK 315
|
330 340 350
....*....|....*....|....*....|.
gi 1717019278 365 QQGVVQGMITGIRGLCNGLGPALYGFIFYIF 395
Cdd:cd17326 316 PQGTMQGVLTASGSLARTLGPIFVTAIYTHF 346
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
2-206 |
4.66e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.12 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 2 TQGKKKKRANRSVMlaKKIVIKDGGTSQGIGSPSVYHAVIVIFLEFFAWGLLTAPTLMVLRKTF---PKHtflmNGLIQG 78
Cdd:cd17331 177 TKSKREKEAKESAS--PPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFgltPEE----NGYLMS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 79 VKGLLSFLS-APLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVIsvsgVFAVTFSVVFAYVAD--ITQ-- 151
Cdd:cd17331 251 YAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFvtTVWQLLVLL----LPLVIGGSVLYTVITslLTKav 326
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1717019278 152 -EHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILV 206
Cdd:cd17331 327 pPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
44-392 |
5.13e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 44 FLEFFAWGL---LTAPTLMVLRKTFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTvfFTCAPIPLMKI 120
Cdd:cd17333 2 YISFFSNGLtdaLLGILGPSLEEAFNLNVADV-SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILG--LLLISLALALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 121 DAWWYFAVISVSGVFA-----VTFSVVFAYVADITQEhERSMAYGLVSATFAASLVTSPAIGAYLsreYGNNLVVVLATA 195
Cdd:cd17333 79 FATPSIYLFVVLMFLAglgagILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSL---LTSELSWSWAYL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 196 IAVLdICFILVAVpESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIvLLICITVFLSYLPEAGQYSSFFLYLRQVmE 275
Cdd:cd17333 155 IIGL-IYLLLAIL-ILLTLFPELPSARNPQQSVGAFSASASRLLRNPSI-ILGALALFLYVGAETAFSSWVPSYLVEK-K 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 276 FSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILL-GLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 354
Cdd:cd17333 231 HVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLsGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTIL 310
|
330 340 350
....*....|....*....|....*....|....*...
gi 1717019278 355 ALVSRTADAdQQGVVQGMITGIRGLCNGLGPALYGFIF 392
Cdd:cd17333 311 SLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
44-392 |
6.19e-03 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 38.77 E-value: 6.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 44 FLEFFAWGLLtAPTLMVLRKTFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI----PLMK 119
Cdd:cd06177 7 FLQFFIWGAW-LVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIGAAAlfyaATVT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 120 iDAWWYFAVISVSGVF-----AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTspaigaYLSREYGNNLVVVLAT 194
Cdd:cd06177 86 -DFSVFFWVMLLYSLCymptlALTNSIAFSNLEDPVKDFPPIRVWGTIGWIAAGWPVG------FLGWEASNLQFYIAAG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 195 AIAVLDI-CFILVAVPeslpekmrPASWGAPISWEQA---DPFASLKKvgQDSIVLLICitVFLSYLPEAGQYSSFFLYL 270
Cdd:cd06177 159 ASLLLGLySLTLPHTP--------PKKAGKGVSKRSLlglDAFVLLKN--PFFAVFFIF--SFLLGAPLQFYYTFANPFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 271 RQVmEFSPESvAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSIT- 349
Cdd:cd06177 227 NDF-GMIVKN-PAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSPGVWMLVLSIILHGVCy 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1717019278 350 ---FPAVSALVSRTADADQQGVVQGMITgirGLCNGLGPALYGFIF 392
Cdd:cd06177 305 dffFVTGYIYVDKKAPKDIRASAQGLFM---LMTNGVGALVGSILS 347
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
89-395 |
8.58e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 8.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 89 PLIGALSDVWGRKS-FLLLTVFFT-----CAPIPlmkiDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGL 161
Cdd:cd17503 49 PLSGWLADRFGTRRlFLTALALFTlgsllCGLAP----NLASLIIFRILQGFGgGVLIPLAQTILLRIYPPEKRGAAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 162 VSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVldICFILVavpeslpekmrpaswgapisweqadPFASLKkVGQ 241
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI--LALLLA-------------------------PLLDLR-LFK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 242 DSIVLLICITVFLSYLpeaGQYSSFF---LYLRQVMEFSPESVAAFIAVLGILSIIAQTIVlSLLMRSIGNKNTILLGL- 317
Cdd:cd17503 177 DRNFTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILSPLV-GRLLDKFGPRLLLLAGLl 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 318 --GFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYI 394
Cdd:cd17503 253 llALGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
|
.
gi 1717019278 395 F 395
Cdd:cd17503 333 R 333
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
47-199 |
9.11e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.43 E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 47 FFAWgLLTAPTLMVLRKTFPKHTFLMNGLiqgVKGLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLM----KID 121
Cdd:cd17367 239 FYTW-TTYLQKFLVNTAGFSKGDATWITT---AALLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLsaldHTD 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019278 122 AWW-YFAVISVSGVFAVTFSVVFAYV-ADITQEHER----SMAYGLVSATFAAslvTSPAIGAYLSREYGNNLVVVLATA 195
Cdd:cd17367 315 SPYtAFALVLVGLVFLSGYTSINAVVkAELFPTHVRalgvGLPYALAVAIFGG---TAPYVALWLKSIGHEWVFFWYVAG 391
|
....
gi 1717019278 196 IAVL 199
Cdd:cd17367 392 LIAI 395
|
|
| |
