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Conserved domains on  [gi|1696098362|ref|XP_029615771|]
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putative transcription factor p65 homolog [Salmo trutta]

Protein Classification

SGNH/GDSL hydrolase family protein( domain architecture ID 10285916)

SGNH/GDSL hydrolase family protein is a hydrolytic enzyme such as an esterase or lipase; may have multifunctional properties including broad substrate specificity and regiospecificity; also contains one or more N-terminal IPT/TIG domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHD-n super family cl08275
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 18-185 1.65e-105

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


The actual alignment was detected with superfamily member cd07885:

Pssm-ID: 447596  Cd Length: 169  Bit Score: 314.89  E-value: 1.65e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGY 97
Cdd:cd07885     2 YVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRISLVTKDPPHKPHPHELVGKDCKDGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  98 YEADLQ-ERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIPEAKVwEEEFDLNAVRLCFQASITLPTGELHPLEPV 176
Cdd:cd07885    82 YEAELSpDRCIHSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQ-RADYDLNAVRLCFQVTVRDPSGRLLPLPPV 160


                  ....*....
gi 1696098362 177 VSQPIYDNR 185
Cdd:cd07885   161 LSQPIYDNR 169
IPT_NFkappaB cd01177
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ...
 192-288 1.60e-57

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.


:

Pssm-ID: 238582  Cd Length: 102  Bit Score: 187.91  E-value: 1.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 192 LKICRVNRNSGSCRGGDEIFLLCDKVQKEDIEVRFFQDS-----WEGKGTFSQADVHRQVAIVFRTPPFYDTNLTEPIRV 266
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEEDeeetvWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 1696098362 267 KMQLRRPSDREVSEPMDFQFLP 288
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102
 
Name Accession Description Interval E-value
RHD-n_RelA cd07885
N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel ...
 18-185 1.65e-105

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.


Pssm-ID: 143645  Cd Length: 169  Bit Score: 314.89  E-value: 1.65e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGY 97
Cdd:cd07885     2 YVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRISLVTKDPPHKPHPHELVGKDCKDGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  98 YEADLQ-ERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIPEAKVwEEEFDLNAVRLCFQASITLPTGELHPLEPV 176
Cdd:cd07885    82 YEAELSpDRCIHSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQ-RADYDLNAVRLCFQVTVRDPSGRLLPLPPV 160


                  ....*....
gi 1696098362 177 VSQPIYDNR 185
Cdd:cd07885   161 LSQPIYDNR 169
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 19-184 1.56e-89

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 273.80  E-value: 1.56e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  19 IEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGYY 98
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDGPAVIRVSLVTKDEPHRPHPHSLVGKDCKDGVC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  99 EADLQ-ERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIP-EAKVWEEEFDLNAVRLCFQASITLPTGE-LHPLEP 175
Cdd:pfam00554  81 EVELGpEDMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNVGfEALRQIKDMDLNVVRLCFQAFLPDTRGNfTTPLPP 160


                  ....*....
gi 1696098362 176 VVSQPIYDN 184
Cdd:pfam00554 161 VVSNPIYDK 169
IPT_NFkappaB cd01177
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ...
 192-288 1.60e-57

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.


Pssm-ID: 238582  Cd Length: 102  Bit Score: 187.91  E-value: 1.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 192 LKICRVNRNSGSCRGGDEIFLLCDKVQKEDIEVRFFQDS-----WEGKGTFSQADVHRQVAIVFRTPPFYDTNLTEPIRV 266
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEEDeeetvWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 1696098362 267 KMQLRRPSDREVSEPMDFQFLP 288
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 193-288 4.87e-54

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 178.91  E-value: 4.87e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 193 KICRVNRNSGSCRGGDEIFLLCDKVQKEDIEVRFFQD-----SWEGKGTFSQADVHRQVAIVFRTPPFYDTNLTEPIRVK 267
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYEEddgqeVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|.
gi 1696098362 268 MQLRRPSDREVSEPMDFQFLP 288
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLP 101
IPT smart00429
ig-like, plexins, transcription factors;
191-287 9.71e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.06  E-value: 9.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  191 ELKICRVNRNSGSCRGGDEIfLLCDKVQKEDIEVRFFQDSWEGKGTFSQAdvhRQVAIVFRTPPFYDTNLTEPIRvKMQL 270
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 1696098362  271 RRpSDREvSEPMDFQFL 287
Cdd:smart00429  76 RN-GGVP-SSPQPFTYV 90
 
Name Accession Description Interval E-value
RHD-n_RelA cd07885
N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel ...
 18-185 1.65e-105

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.


Pssm-ID: 143645  Cd Length: 169  Bit Score: 314.89  E-value: 1.65e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGY 97
Cdd:cd07885     2 YVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRISLVTKDPPHKPHPHELVGKDCKDGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  98 YEADLQ-ERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIPEAKVwEEEFDLNAVRLCFQASITLPTGELHPLEPV 176
Cdd:cd07885    82 YEAELSpDRCIHSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQ-RADYDLNAVRLCFQVTVRDPSGRLLPLPPV 160


                  ....*....
gi 1696098362 177 VSQPIYDNR 185
Cdd:cd07885   161 LSQPIYDNR 169
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 19-184 1.56e-89

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 273.80  E-value: 1.56e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  19 IEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGYY 98
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDGPAVIRVSLVTKDEPHRPHPHSLVGKDCKDGVC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  99 EADLQ-ERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIP-EAKVWEEEFDLNAVRLCFQASITLPTGE-LHPLEP 175
Cdd:pfam00554  81 EVELGpEDMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNVGfEALRQIKDMDLNVVRLCFQAFLPDTRGNfTTPLPP 160


                  ....*....
gi 1696098362 176 VVSQPIYDN 184
Cdd:pfam00554 161 VVSNPIYDK 169
RHD-n cd07827
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 18-185 1.34e-79

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


Pssm-ID: 143640  Cd Length: 174  Bit Score: 248.44  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGK-DCKHG 96
Cdd:cd07827     2 YLEITEQPKQRGHRFRYECEGRSAGSIPGENSTADRKTFPTVKLRNYNGPAKIVVSLVTKDDPPKPHPHQLVGKtDCRDG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  97 YYEADL--QERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIPEAKVWE-EEFDLNAVRLCFQASI-TLPTGELHP 172
Cdd:cd07827    82 VCEVRLgpKNNMTASFNNLGIQCVRKKDVEEALGQRIQLGIDPFMVHKGPEGNaSDIDLNRVRLCFQAFIeDSDGGFTLP 161

                         170
                  ....*....|...
gi 1696098362 173 LEPVVSQPIYDNR 185
Cdd:cd07827   162 LPPVLSNPIYDKK 174
RHD-n_c-Rel cd07933
N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel ...
 18-185 7.91e-76

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.


Pssm-ID: 143649  Cd Length: 172  Bit Score: 238.62  E-value: 7.91e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGY 97
Cdd:cd07933     2 YVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRITLVTKNEPYKPHPHDLVGKDCRDGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  98 YEADL-QERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIPEAKVWE-EEFDLNAVRLCFQASITLPTGEL-HPLE 174
Cdd:cd07933    82 YEAEFgPERRVLAFQNLGIQCVRRREVKEAIMLRISRGINPFNVPEEQLLQiEEYDLNVVRLCFQIFLPDEHGNYtTALP 161

                         170
                  ....*....|.
gi 1696098362 175 PVVSQPIYDNR 185
Cdd:cd07933   162 PIVSNPIYDNR 172
RHD-n_Dorsal_Dif cd07887
N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal; ...
 18-185 8.08e-60

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Dorsal and Dif (Dorsal-related immunity factor), and similar proteins. Dorsal and Dif are Rel-like transcription factors, which play roles in mediating innate immunity in Drosophila. They are activated via the Toll pathway. Cytoplasmic Dorsal/Dif are inactivated via forming a complex with Cactus, the Drosophila homologue of mammalian I-kappa B proteins. In response to signals, Cactus is degraded and Dorsal/Dif can be transported into the nucleus, where they act as transcription factors. Dorsal is also an essential gene in establishing the proper dorsal/ventral polarity in the developing embryo.


Pssm-ID: 143647  Cd Length: 173  Bit Score: 196.55  E-value: 8.08e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGK-DCKHG 96
Cdd:cd07887     2 YVRIVEQPTSRALRFRYECEGRSAGSIPGANSTSEGKTFPTIQVVNYDGRAVVVVSCVTKDEPFRPHPHNLVGKeGCKKG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  97 YYEADLQ-ERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIP-EAKVWEEEFDLNAVRLCFQASITLPTGEL-HPL 173
Cdd:cd07887    82 VCTKKINpTEMRIVFQKLGIQCVKKKDVEESLKLREEINVDPFRTGfDHKDQINSIDLNVVRLCFQVFLEDENGRFtVPL 161

                         170
                  ....*....|..
gi 1696098362 174 EPVVSQPIYDNR 185
Cdd:cd07887   162 PPVVSDPIYDKK 173
RHD-n_RelB cd07886
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral ...
 21-185 4.02e-59

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.


Pssm-ID: 143646  Cd Length: 172  Bit Score: 194.69  E-value: 4.02e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  21 IIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNG--PLRVRVSLVTKNPPHKPHPHELVGKDCKHGYY 98
Cdd:cd07886     5 ITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGlkEVTVTVCLVWKDPPHRVHPHGLVGKDCPNGIC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  99 EADLQER--RVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIPEAKVwEEEFDLNAVRLCFQASITLPTGELHPLEPV 176
Cdd:cd07886    85 QVTLNPHssPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKN-HEEVDMNVVRLCFQASYRDDDGRKDCLSPV 163


                  ....*....
gi 1696098362 177 VSQPIYDNR 185
Cdd:cd07886   164 LSEPIYDKK 172
IPT_NFkappaB cd01177
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ...
 192-288 1.60e-57

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.


Pssm-ID: 238582  Cd Length: 102  Bit Score: 187.91  E-value: 1.60e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 192 LKICRVNRNSGSCRGGDEIFLLCDKVQKEDIEVRFFQDS-----WEGKGTFSQADVHRQVAIVFRTPPFYDTNLTEPIRV 266
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEEDeeetvWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 1696098362 267 KMQLRRPSDREVSEPMDFQFLP 288
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 193-288 4.87e-54

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 178.91  E-value: 4.87e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 193 KICRVNRNSGSCRGGDEIFLLCDKVQKEDIEVRFFQD-----SWEGKGTFSQADVHRQVAIVFRTPPFYDTNLTEPIRVK 267
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYEEddgqeVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|.
gi 1696098362 268 MQLRRPSDREVSEPMDFQFLP 288
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLP 101
RHD-n_NFkB cd07883
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa light ...
 18-185 1.48e-46

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-kappa B); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 and B2 families of transcription factors, also referred to as class I members of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. Family members include NF-kappa B1 and NF-kappa B2. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form), while NF-kappa B2 is called p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). p105 and p100 may also act as I-kappa Bs due to their C-terminal ankyrin repeats.


Pssm-ID: 143643  Cd Length: 197  Bit Score: 162.26  E-value: 1.48e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGY 97
Cdd:cd07883     2 YLEILEQPKQRGFRFRYGCEGPSHGGLPGASSEKNKKSYPTVKICNYQGPARIVVQLVTNSEPPRLHAHSLVGKHCEDGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  98 YEADL-QERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQNNPFNIP--------------------------EAKVWEEEF 150
Cdd:cd07883    82 CTVQVgPKDMTAQFPNLGILHVTKKNVVETLEARLLAQCTRGYNPgdlvhvdaegggdrqltdeeqaeirqKAKQQAKSM 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1696098362 151 DLNAVRLCFQASITLPTGEL-HPLEPVVSQPIYDNR 185
Cdd:cd07883   162 DLSVVRLCFQAFLPDSNGSFtRPLKPVISDAIYDSK 197
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 192-288 2.33e-41

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 144.73  E-value: 2.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 192 LKICRVNRNSGSCRGGDEIFLLCDKVQKEDIEVRFF-----QDSWEGKGTFSQADVHrQVAIVFRTPPFYDTNLTEPIRV 266
Cdd:cd00602     1 LPICRVSSLSGSVNGGDEVFLLCDKVNKPDIKVWFGekgpgETVWEAEAMFRQEDVR-QVAIVFKTPPYHNKWITRPVQV 79

                          90       100
                  ....*....|....*....|..
gi 1696098362 267 KMQLRRPSDREVSEPMDFQFLP 288
Cdd:cd00602    80 PIQLVRPDDRKRSEPLTFTYTP 101
RHD-n_NFkB2 cd07934
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2) ...
 17-185 9.52e-34

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B2 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B2 is commonly referred to as p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B2 is involved in the alternative NF-kappa B signaling pathway which is activated by few agonists and plays an important role in secondary lymphoid organogenesis, maturation of B-cells, and adaptive humoral immunity. p100 may also act as an I-kappa B due to its C-terminal ankyrin repeats.


Pssm-ID: 143650  Cd Length: 185  Bit Score: 126.94  E-value: 9.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  17 SFIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDC-KH 95
Cdd:cd07934     1 PYLVIIEQPKQRGFRFRYVCEGPSHGGLPGASSEKGRKTYPTVKICNYVGMARIEVDLVTHTDPPRVHAHSLVGKHCnES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  96 GYYEADL-QERRVHSFQNLGIQCVKKKDVNEAVSCRLQTQ---NNPFNI----------PEAKVWEEEFDLNAVRLCFQA 161
Cdd:cd07934    81 GNCSVDVgPKDMTAQFSNLGILHVTKKNMMEILKEKLKRQklrNTGPYKlteaeereleQEAKELKKVMDLSIVRLKFTA 160

                         170       180
                  ....*....|....*....|....*
gi 1696098362 162 SITLPTGELH-PLEPVVSQPIYDNR 185
Cdd:cd07934   161 YLRDSNGSYTlALKPVISDPIHDSK 185
RHD-n_NFkB1 cd07935
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa ...
 18-185 2.73e-33

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B1 is involved in the canonical NF-kappa B signaling pathway which is activated by many agonists and is essential in immune and inflammatory responses, as well as cell survival. p105 is involved in its own specific NF-kappa B signaling pathway which is also implicated in immune and inflammatory responses. p105 may also act as an I-kappa B due to its C-terminal ankyrin repeats. It is also involved in mitogen-activated protein kinase (MAPK) signaling as its degradation leads to the activation of TPL-2, a MAPK kinase kinase which activates ERK pathways.


Pssm-ID: 143651  Cd Length: 202  Bit Score: 126.16  E-value: 2.73e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRGMRFRYKCEGRSAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGKDCKHGY 97
Cdd:cd07935     2 YLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  98 YEADLQER-RVHSFQNLGIQCVKKKDVNEAVSCRLQ------------------------------TQNNPFNIPEAKVW 146
Cdd:cd07935    82 CTVTAGPKdMVVGFANLGILHVTKKKVFETLEARMTeackkgynpgllvhpelaylqaegggdrqlTEREKEIIRQAAVQ 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1696098362 147 E-EEFDLNAVRLCFQASITLPTGEL-HPLEPVVSQPIYDNR 185
Cdd:cd07935   162 QtKEMDLSVVRLMFTAFLPDSTGGFtRRLEPVVSDAIYDSK 202
RHD-n_Relish cd07884
N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish; ...
 18-183 2.09e-30

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Relish protein, in which the RHD domain co-occurs with C-terminal ankyrin repeats. Family members are sometimes referred to as p110 or p68 (proteolytically processed form). Relish is an NF-kappa B-like transcription factor, which plays a role in mediating innate immunity in Drosophila. It is activated via the Imd (immune deficiency) pathway, which triggers phosphorylation of Relish. IKK-dependent proteolytic cleavage of Relish (which involves Dredd) results in a smaller active form (without the C-terminal ankyrin repeats), which is transported into the nucleus and functions as a transactivator.


Pssm-ID: 143644  Cd Length: 159  Bit Score: 116.76  E-value: 2.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  18 FIEIIEQPKPRgMRFRYKCEGR-SAGSIPGEKSNDTTKTHPAIKVHNYNGPLRVRVSLVTKNPPH-KPHPHELVGKDCKH 95
Cdd:cd07884     2 FLRIVEQPVDK-FRFRYKSEMHgTHGSLLGERSTSSKKTFPTVKLCNYRGQAVIRCSLYQADDNRrKPHVHKLVGKQGDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  96 GYYEADLQERR-----VHSFQNLGIQCVKKKdvneavscrlqtqnnpfNIPEAKVWEEEFDLNAVRLCFQASITLPTGEL 170
Cdd:cd07884    81 DVCDPHDIEVSpegdyVAMFQNMGIIHTAKK-----------------NIPEELYKKKNMNLNQVVLRFQAFAVSANGHL 143

                         170
                  ....*....|....
gi 1696098362 171 HPL-EPVVSQPIYD 183
Cdd:cd07884   144 RPIcPPVYSNPINN 157
IPT smart00429
ig-like, plexins, transcription factors;
191-287 9.71e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 67.06  E-value: 9.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362  191 ELKICRVNRNSGSCRGGDEIfLLCDKVQKEDIEVRFFQDSWEGKGTFSQAdvhRQVAIVFRTPPFYDTNLTEPIRvKMQL 270
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 1696098362  271 RRpSDREvSEPMDFQFL 287
Cdd:smart00429  76 RN-GGVP-SSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 192-288 9.98e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 61.32  E-value: 9.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 192 LKICRVNRNSGSCRGGDEIFLLCDKVQKE-DIEVRFFqdsweGKGTFSQADVHrQVAIVFRTPPFydtNLTEPIRVKMQL 270
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFG-----GGVPCSVLSVS-STAIVCTTPPY---ANPGPGPVEVTV 71

                          90
                  ....*....|....*...
gi 1696098362 271 RRPSDREVSEPMDFQFLP 288
Cdd:cd00102    72 DRGNGGITSSPLTFTYVP 89
RHD-n_NFAT_like cd07927
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 19-91 2.58e-08

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143648  Cd Length: 161  Bit Score: 53.43  E-value: 2.58e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1696098362  19 IEIIEQPKPRgMRFRYKCEGrSAGSIPGEksndTTKTHPAIKVHNYNGPLRVRVSLVTKNPPHKPHPHELVGK 91
Cdd:cd07927     3 LRIEVQPEPH-HRARYETEG-SRGAVKAP----STGGFPTVKLHGYMEPVGLQVFIGTASGRLKPHAFYQVHR 69
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 194-288 8.80e-04

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 39.01  E-value: 8.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696098362 194 ICRVNRNSGSCRGGDEIFLLCDKVQKeDIEVRFF------QDSWEGKGTFSQADVHrQVAIVFRTPPFYDTNLTEPIRVK 267
Cdd:cd01178     4 IEKKSLNSCSVNGGEELFLTGKNFLK-DSKVVFQekgqdgEAQWEAEATIDKEKSH-QNHLVVEVPPYHNKHVAAPVQVQ 81

                          90       100
                  ....*....|....*....|.
gi 1696098362 268 MQLRRpSDREVSEPMDFQFLP 288
Cdd:cd01178    82 FYVVN-GKRKRSQPQTFTYTP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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