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Conserved domains on  [gi|1696148135|ref|XP_029582718|]
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interferon a3-like [Salmo trutta]

Protein Classification

alpha/beta interferon family protein( domain architecture ID 10444641)

alpha/beta interferon family protein produces antiviral and antiproliferative response in cell

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFab super family cl00092
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 28-179 1.46e-31

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


The actual alignment was detected with superfamily member pfam00143:

Pssm-ID: 469611  Cd Length: 160  Bit Score: 111.52  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135  28 QFRLGKLNDVSIALLSDMGGLFPLMCAEENVEQTFPEDLYKNT--EGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLN 105
Cdd:pfam00143   2 PQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILSGSqlQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLLE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1696148135 106 MFQNVIYRQVQNLELCVVGGV-WESSGDGWSVT---LKTYFNKLNTVLKEKEHSACAWEIVRKEIRENLVQFKKFIDS 179
Cdd:pfam00143  82 QLLNGLHQQLEDLETCLGEEMeEEESPLGNEDSrlaLKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRLTER 159
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 28-179 1.46e-31

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 111.52  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135  28 QFRLGKLNDVSIALLSDMGGLFPLMCAEENVEQTFPEDLYKNT--EGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLN 105
Cdd:pfam00143   2 PQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILSGSqlQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLLE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1696148135 106 MFQNVIYRQVQNLELCVVGGV-WESSGDGWSVT---LKTYFNKLNTVLKEKEHSACAWEIVRKEIRENLVQFKKFIDS 179
Cdd:pfam00143  82 QLLNGLHQQLEDLETCLGEEMeEEESPLGNEDSrlaLKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRLTER 159
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 41-170 5.41e-20

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 81.61  E-value: 5.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135  41 LLSDMGGLFPLMCAEENVEQTFPEDLYKNT--EGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLNMFQNVIYRQVQNL 118
Cdd:cd00095    15 LLRQMRRLPPQSCLKDRADFGFPQELLQGDqfQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1696148135 119 ELCVVGGVWESS---GDGWSVTLKTYFNKLNTVLKEKEHSACAWEIVRKEIRENL 170
Cdd:cd00095    95 ETCLEQEMGEEEtpgPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIMRNF 149
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 62-170 1.35e-17

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 74.27  E-value: 1.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135   62 FPEDLY--KNTEGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLNMFQNVIYRQVQNLELCVVGGVWESS---GDGWSV 136
Cdd:smart00076   4 FPEEILdgSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEEtplTRNTHL 83

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1696148135  137 TLKTYFNKLNTVLKEKEHSACAWEIVRKEIRENL 170
Cdd:smart00076  84 ALKKYFQRIQLYLKEKKYSPCAWEVVRVEIRRNF 117
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 28-179 1.46e-31

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 111.52  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135  28 QFRLGKLNDVSIALLSDMGGLFPLMCAEENVEQTFPEDLYKNT--EGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLN 105
Cdd:pfam00143   2 PQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILSGSqlQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLLE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1696148135 106 MFQNVIYRQVQNLELCVVGGV-WESSGDGWSVT---LKTYFNKLNTVLKEKEHSACAWEIVRKEIRENLVQFKKFIDS 179
Cdd:pfam00143  82 QLLNGLHQQLEDLETCLGEEMeEEESPLGNEDSrlaLKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRLTER 159
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 41-170 5.41e-20

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 81.61  E-value: 5.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135  41 LLSDMGGLFPLMCAEENVEQTFPEDLYKNT--EGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLNMFQNVIYRQVQNL 118
Cdd:cd00095    15 LLRQMRRLPPQSCLKDRADFGFPQELLQGDqfQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1696148135 119 ELCVVGGVWESS---GDGWSVTLKTYFNKLNTVLKEKEHSACAWEIVRKEIRENL 170
Cdd:cd00095    95 ETCLEQEMGEEEtpgPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIMRNF 149
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 62-170 1.35e-17

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 74.27  E-value: 1.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696148135   62 FPEDLY--KNTEGEDVYVVALEAMRYVEQLYNNSLTSVTWNKTKLNMFQNVIYRQVQNLELCVVGGVWESS---GDGWSV 136
Cdd:smart00076   4 FPEEILdgSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEEtplTRNTHL 83

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1696148135  137 TLKTYFNKLNTVLKEKEHSACAWEIVRKEIRENL 170
Cdd:smart00076  84 ALKKYFQRIQLYLKEKKYSPCAWEVVRVEIRRNF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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