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Conserved domains on  [gi|1679851681|ref|XP_029335056|]
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heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3 [Mus caroli]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
2-187 1.66e-36

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 127.84  E-value: 1.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681   2 PRTLETQITLEKTPSYFvtqeaprrifnMSRDTKLIVVVRNPVTRAISDYTQT----LSKKPDIPTFEGLSFRNRslglv 77
Cdd:pfam00685  72 PRIIKTHLPLHLLPKSL-----------WDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDFLNG----- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681  78 dvswnAIRIGMYALHLESWLRYFPLAQIHFVSGERLITDPAGEMGRIQDFLGIKRF-----ITDKHFYFNKTKGFPCLKK 152
Cdd:pfam00685 136 -----KVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeeldKIVKHLSFENMKGNPCLNY 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1679851681 153 PEST-----LLPRCLGKSKgrtHVQIDPEVIDQLREFYRP 187
Cdd:pfam00685 211 SKLPkevspFFRKGLVGDW---KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
2-187 1.66e-36

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 127.84  E-value: 1.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681   2 PRTLETQITLEKTPSYFvtqeaprrifnMSRDTKLIVVVRNPVTRAISDYTQT----LSKKPDIPTFEGLSFRNRslglv 77
Cdd:pfam00685  72 PRIIKTHLPLHLLPKSL-----------WDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDFLNG----- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681  78 dvswnAIRIGMYALHLESWLRYFPLAQIHFVSGERLITDPAGEMGRIQDFLGIKRF-----ITDKHFYFNKTKGFPCLKK 152
Cdd:pfam00685 136 -----KVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeeldKIVKHLSFENMKGNPCLNY 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1679851681 153 PEST-----LLPRCLGKSKgrtHVQIDPEVIDQLREFYRP 187
Cdd:pfam00685 211 SKLPkevspFFRKGLVGDW---KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
2-187 1.66e-36

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 127.84  E-value: 1.66e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681   2 PRTLETQITLEKTPSYFvtqeaprrifnMSRDTKLIVVVRNPVTRAISDYTQT----LSKKPDIPTFEGLSFRNRslglv 77
Cdd:pfam00685  72 PRIIKTHLPLHLLPKSL-----------WDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDFLNG----- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681  78 dvswnAIRIGMYALHLESWLRYFPLAQIHFVSGERLITDPAGEMGRIQDFLGIKRF-----ITDKHFYFNKTKGFPCLKK 152
Cdd:pfam00685 136 -----KVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeeldKIVKHLSFENMKGNPCLNY 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1679851681 153 PEST-----LLPRCLGKSKgrtHVQIDPEVIDQLREFYRP 187
Cdd:pfam00685 211 SKLPkevspFFRKGLVGDW---KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
11-130 6.55e-13

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 63.85  E-value: 6.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679851681  11 LEKTPSYFVTQEAPRRIFnmsRDTKLIVVVRNPVTRAISDYTQtlskkpdIPTFEGLSFRNRSLGLVDVSWNAIRIGMYA 90
Cdd:pfam13469  62 CDKSPSHLFHLDLLLKAF---PDAKFIHLHRDPVDTVISSYCS-------LFGFTLSSYSTAFLRDIGLALARWSRAYER 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1679851681  91 LHlESWLRYFPlAQIHFVSGERLITDPAGEMGRIQDFLGI 130
Cdd:pfam13469 132 LM-AARARVPP-GRFLDVRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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