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Conserved domains on  [gi|1622947310|ref|XP_028705589|]
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probable histidine--tRNA ligase, mitochondrial isoform X1 [Macaca mulatta]

Protein Classification

histidine--tRNA ligase( domain architecture ID 1007767)

histidine--tRNA ligase (HisRS) is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA

CATH:  3.40.50.800|3.30.930.10
EC:  6.1.1.21
Gene Ontology:  GO:0003723|GO:0042802|GO:0004821|GO:0006427|GO:0005524|GO:0006412

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02972 super family cl33611
Histidyl-tRNA synthetase
 12-509 0e+00

Histidyl-tRNA synthetase


The actual alignment was detected with superfamily member PLN02972:

Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 535.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  12 WAALLSQLLRPPCASCTGAVrcqSQVAEAVLTSQLKahqEKPnfiiKIPKGTRDLSPQHMVVREKILDLVISCFKRHGAK 91
Cdd:PLN02972  292 WATQLLLLFDPKCPGFDSLV---DKVKEIVESNEVR---RLP----KIPKGTRDFAKEQMAIREKAFSIITSVFKRHGAT 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  92 GMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTypssltdlceVPFARYLAMNKVKKMKRYHVGKVWRRES 171
Cdd:PLN02972  362 ALDTPVFELRETLMGKYGEDSKLIYDLADQGGELCSLRYDLT----------VPFARYVAMNGITSFKRYQIAKVYRRDN 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 172 PSivQGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAACGVPESKFRAICSSIDK 251
Cdd:PLN02972  432 PS--KGRYREFYQCDFDIAGVYEPMGPDFEIIKVLTELLDELDIGTYEVKLNHRKLLDGMLEICGVPPEKFRTICSSIDK 509

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 252 LDKMAWKDVRHEMVAKKGLAPEVADRIGDYVQCHGG-VSLVEQMFQ-DPRLSQNKQALEGLEDLKLLFEYLNLFGIAEKI 329
Cdd:PLN02972  510 LDKQSFEQVKKEMVEEKGLSNETADKIGNFVKERGPpLELLSKLRQeGSEFLGNASSRAALDELEIMFKALEKSKAIGKI 589

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 330 SFDLSLARGLDYYTGVIYEAVLLQTptqageeplNVGSVAAGGRYDGLVGMFDPKghKVPCVGLSIGVERIFYIVEQRMK 409
Cdd:PLN02972  590 VFDLSLARGLDYYTGVIYEAVFKGA---------QVGSIAAGGRYDNLVGMFSGK--QVPAVGVSLGIERVFAIMEQQEE 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 410 TKGEKVRTTETQVFVATPQKNFLQERLKLITELWDAGIKAEmlYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGIIKI 489
Cdd:PLN02972  659 EKSQVIRPTETEVLVSIIGDDKLALAAELVSELWNAGIKAE--YKVSTRKAKHLKRAKESGIPWMVLVGEKELSKGFVKL 736

                         490       500
                  ....*....|....*....|
gi 1622947310 490 RSVASREEVSGSSRNRRDEL 509
Cdd:PLN02972  737 KNLEAGVEEEVDRTCFVQEL 756
 
Name Accession Description Interval E-value
PLN02972 PLN02972
Histidyl-tRNA synthetase
 12-509 0e+00

Histidyl-tRNA synthetase


Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 535.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  12 WAALLSQLLRPPCASCTGAVrcqSQVAEAVLTSQLKahqEKPnfiiKIPKGTRDLSPQHMVVREKILDLVISCFKRHGAK 91
Cdd:PLN02972  292 WATQLLLLFDPKCPGFDSLV---DKVKEIVESNEVR---RLP----KIPKGTRDFAKEQMAIREKAFSIITSVFKRHGAT 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  92 GMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTypssltdlceVPFARYLAMNKVKKMKRYHVGKVWRRES 171
Cdd:PLN02972  362 ALDTPVFELRETLMGKYGEDSKLIYDLADQGGELCSLRYDLT----------VPFARYVAMNGITSFKRYQIAKVYRRDN 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 172 PSivQGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAACGVPESKFRAICSSIDK 251
Cdd:PLN02972  432 PS--KGRYREFYQCDFDIAGVYEPMGPDFEIIKVLTELLDELDIGTYEVKLNHRKLLDGMLEICGVPPEKFRTICSSIDK 509

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 252 LDKMAWKDVRHEMVAKKGLAPEVADRIGDYVQCHGG-VSLVEQMFQ-DPRLSQNKQALEGLEDLKLLFEYLNLFGIAEKI 329
Cdd:PLN02972  510 LDKQSFEQVKKEMVEEKGLSNETADKIGNFVKERGPpLELLSKLRQeGSEFLGNASSRAALDELEIMFKALEKSKAIGKI 589

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 330 SFDLSLARGLDYYTGVIYEAVLLQTptqageeplNVGSVAAGGRYDGLVGMFDPKghKVPCVGLSIGVERIFYIVEQRMK 409
Cdd:PLN02972  590 VFDLSLARGLDYYTGVIYEAVFKGA---------QVGSIAAGGRYDNLVGMFSGK--QVPAVGVSLGIERVFAIMEQQEE 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 410 TKGEKVRTTETQVFVATPQKNFLQERLKLITELWDAGIKAEmlYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGIIKI 489
Cdd:PLN02972  659 EKSQVIRPTETEVLVSIIGDDKLALAAELVSELWNAGIKAE--YKVSTRKAKHLKRAKESGIPWMVLVGEKELSKGFVKL 736

                         490       500
                  ....*....|....*....|
gi 1622947310 490 RSVASREEVSGSSRNRRDEL 509
Cdd:PLN02972  737 KNLEAGVEEEVDRTCFVQEL 756
HisS COG0124
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA ...
 57-499 6.83e-108

Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439894 [Multi-domain]  Cd Length: 422  Bit Score: 329.39  E-value: 6.83e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  57 IKIPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSG--LMYDLKDQGGELLSLRYDLTy 134
Cdd:COG0124     4 IQAPRGTRDILPEESAKWQYVEDTIREVFERYGFQEIRTPIFEYTELFARKIGEDIVekEMYTFEDRGGRSLTLRPEGT- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 135 pssltdlceVPFARYLAMNK---VKKMKRYHVGKVWRRESPsivQ-GRYREFCQCDFDIAGQFDPMIpDAECLKIMCEIL 210
Cdd:COG0124    83 ---------APVARAVAEHGnelPFPFKLYYIGPVFRYERP---QkGRYRQFHQFGVEVIGSDSPLA-DAEVIALAADLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 211 SGLQLGDFLIKVNDRrivdgmfaacGVPESKFRAICSSIDKLDKMAWKDVrhemvakkgLAPEVADRIG-----DYVQCH 285
Cdd:COG0124   150 KALGLKDFTLEINSR----------GLPEERAEALLRYLDKLDKIGHEDV---------LDEDSQRRLEtnplrAILDSK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 286 GGV--SLVEQMfqdPRLSQNKqALEGLEDLKLLFEYLNLFGIaeKISFDLSLARGLDYYTGVIYEAVLLQTPTQageepl 363
Cdd:COG0124   211 GPDcqEVLADA---PKLLDYL-GEEGLAHFEEVLELLDALGI--PYVIDPRLVRGLDYYTGTVFEIVTDGLGAQ------ 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 364 nvGSVAAGGRYDGLVGMFDpkGHKVPCVGLSIGVERIFYIVEQRmktKGEKVRTTETQVFVATPQKNFLQERLKLITELW 443
Cdd:COG0124   279 --GSVCGGGRYDGLVEQLG--GPPTPAVGFAIGLERLLLLLEEL---GLLPAAEPPPDVYVVPLGEEARAEALKLAQELR 351

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622947310 444 DAGIKAEMLYKNNpKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREEVS 499
Cdd:COG0124   352 AAGIRVELDLGGR-KLKKQLKYADKSGAPFVLILGEDELANGTVTLKDLATGEQET 406
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 71-405 8.58e-96

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 292.58  E-value: 8.58e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  71 MVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSG-LMYDLKDQGGELLSLRYDLTypssltdlceVPFARY 149
Cdd:cd00773     2 AALRRYIEDTLREVFERYGYEEIDTPVFEYTELFLRKSGDEVSkEMYRFKDKGGRDLALRPDLT----------APVARA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 150 LAMNKVKK---MKRYHVGKVWRRESPSivQGRYREFCQCDFDIAGqFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRR 226
Cdd:cd00773    72 VAENLLSLplpLKLYYIGPVFRYERPQ--KGRYREFYQVGVEIIG-SDSPLADAEVIALAVEILEALGLKDFQIKINHRG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 227 IVDGmfaACGVPESKFRAICSSIDKLDKmawkdvrhemvakkglapevadrigdyvqchggvslveqmfqdprlsqnkqa 306
Cdd:cd00773   149 ILDG---IAGLLEDREEYIERLIDKLDK---------------------------------------------------- 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 307 lEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVLLQTPTQageeplnvGSVAAGGRYDGLVGMFDpkGH 386
Cdd:cd00773   174 -EALAHLEKLLDYLEALGVDIKYSIDLSLVRGLDYYTGIVFEAVADGLGAQ--------GSIAGGGRYDGLLEEFG--GE 242

                         330
                  ....*....|....*....
gi 1622947310 387 KVPCVGLSIGVERIFYIVE 405
Cdd:cd00773   243 DVPAVGFAIGLERLLLALE 261
hisS TIGR00442
histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed ...
 58-499 2.91e-92

histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273080 [Multi-domain]  Cd Length: 404  Bit Score: 288.61  E-value: 2.91e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  58 KIPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGL----MYDLKDQGGELLSLRYDLT 133
Cdd:TIGR00442   1 QKPRGTRDFLPEEMIKWQYIEETIREVFERYGFKEIRTPIFEYTELFKRKVGEETDIvskeMYTFKDKGGRSLTLRPEGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 134 ypssltdlceVPFARYLAMNK---VKKMKRYHVGKVWRRESPsivQ-GRYREFCQCDFDIAGQFDPMIpDAECLKIMCEI 209
Cdd:TIGR00442  81 ----------APVARAVIENKlllPKPFKLYYIGPMFRYERP---QkGRYRQFHQFGVEVIGSDSPLA-DAEIIALAADI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 210 LSGLQLGDFLIKVNDRRIVDGMFAacgvpesKFRAICSSIDK-LDKMAWKDVRHEMVAKKGLAPEVADRIGDYVQchggv 288
Cdd:TIGR00442 147 LKELGLKDFTLEINSLGILEGRLE-------YREALIRYLDKhKDKLGEDSVRRLEKNPLRILDSKNEKIQELLK----- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 289 slveqmfQDPRLSQNKQAlEGLEDLKLLFEYLNLFGIaeKISFDLSLARGLDYYTGVIYEAVLLQTPTQageeplnvGSV 368
Cdd:TIGR00442 215 -------NAPKILDFLCE-ESRAHFEELKELLDALGI--PYKIDPSLVRGLDYYTGTVFEFVTDDLGAQ--------GSI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 369 AAGGRYDGLVGMFDpkGHKVPCVGLSIGVERIFYIVEQRmktKGEKVRTTETQVFVATPQKNFLQERLKLITELWDAGIK 448
Cdd:TIGR00442 277 CGGGRYDGLVEELG--GPPTPAVGFAIGIERLILLLEEL---GLIPPPSKKPDVYVVPLGEEAELEALKLAQKLRKAGIR 351

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622947310 449 AEMLYKNNpKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREEVS 499
Cdd:TIGR00442 352 VEVDLGGR-KLKKQLKYADKLGARFALIIGEDELENGTVTLKDLETGEQET 401
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 62-400 2.89e-39

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 145.42  E-value: 2.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  62 GTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTyPSsltdl 141
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLDQTFKLVDQSGRLLGLRADIT-PQ----- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 142 cevpFARYLA--MNKVKKMKRYHVGKVWRRESPSIvqGRYREFCQCDFDIAGQFDPMiPDAECLKIMCEILSGLQLGDFL 219
Cdd:pfam13393  75 ----VARIDAhrLNRPGPLRLCYAGSVLRTRPKGL--GRSREPLQVGAELIGHAGIE-ADAEIISLLLEALAAAGVPGVT 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 220 IKVNDRRIVDGMFAACGVPESKFRAICSSIDKLDkmaWKDVRhEMVAKKGLAPEVADRIGDYVQCHGGVSLVEQMFQdpR 299
Cdd:pfam13393 148 LDLGHVGLVRALLEAAGLSEALEEALRAALQRKD---AAELA-ELAAEAGLPPALRRALLALPDLYGGPEVLDEARA--A 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 300 LSQNKQALEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVLLQTPtqageeplnvGSVAAGGRYDGLVG 379
Cdd:pfam13393 222 LPGLPALQEALDELEALAALLEALGDGVRLTFDLAELRGYEYYTGIVFAAYAPGVG----------EPLARGGRYDDLGA 291

                         330       340
                  ....*....|....*....|.
gi 1622947310 380 MFdpkGHKVPCVGLSIGVERI 400
Cdd:pfam13393 292 AF---GRARPATGFSLDLEAL 309
 
Name Accession Description Interval E-value
PLN02972 PLN02972
Histidyl-tRNA synthetase
 12-509 0e+00

Histidyl-tRNA synthetase


Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 535.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  12 WAALLSQLLRPPCASCTGAVrcqSQVAEAVLTSQLKahqEKPnfiiKIPKGTRDLSPQHMVVREKILDLVISCFKRHGAK 91
Cdd:PLN02972  292 WATQLLLLFDPKCPGFDSLV---DKVKEIVESNEVR---RLP----KIPKGTRDFAKEQMAIREKAFSIITSVFKRHGAT 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  92 GMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTypssltdlceVPFARYLAMNKVKKMKRYHVGKVWRRES 171
Cdd:PLN02972  362 ALDTPVFELRETLMGKYGEDSKLIYDLADQGGELCSLRYDLT----------VPFARYVAMNGITSFKRYQIAKVYRRDN 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 172 PSivQGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAACGVPESKFRAICSSIDK 251
Cdd:PLN02972  432 PS--KGRYREFYQCDFDIAGVYEPMGPDFEIIKVLTELLDELDIGTYEVKLNHRKLLDGMLEICGVPPEKFRTICSSIDK 509

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 252 LDKMAWKDVRHEMVAKKGLAPEVADRIGDYVQCHGG-VSLVEQMFQ-DPRLSQNKQALEGLEDLKLLFEYLNLFGIAEKI 329
Cdd:PLN02972  510 LDKQSFEQVKKEMVEEKGLSNETADKIGNFVKERGPpLELLSKLRQeGSEFLGNASSRAALDELEIMFKALEKSKAIGKI 589

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 330 SFDLSLARGLDYYTGVIYEAVLLQTptqageeplNVGSVAAGGRYDGLVGMFDPKghKVPCVGLSIGVERIFYIVEQRMK 409
Cdd:PLN02972  590 VFDLSLARGLDYYTGVIYEAVFKGA---------QVGSIAAGGRYDNLVGMFSGK--QVPAVGVSLGIERVFAIMEQQEE 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 410 TKGEKVRTTETQVFVATPQKNFLQERLKLITELWDAGIKAEmlYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGIIKI 489
Cdd:PLN02972  659 EKSQVIRPTETEVLVSIIGDDKLALAAELVSELWNAGIKAE--YKVSTRKAKHLKRAKESGIPWMVLVGEKELSKGFVKL 736

                         490       500
                  ....*....|....*....|
gi 1622947310 490 RSVASREEVSGSSRNRRDEL 509
Cdd:PLN02972  737 KNLEAGVEEEVDRTCFVQEL 756
HisS COG0124
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA ...
 57-499 6.83e-108

Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439894 [Multi-domain]  Cd Length: 422  Bit Score: 329.39  E-value: 6.83e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  57 IKIPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSG--LMYDLKDQGGELLSLRYDLTy 134
Cdd:COG0124     4 IQAPRGTRDILPEESAKWQYVEDTIREVFERYGFQEIRTPIFEYTELFARKIGEDIVekEMYTFEDRGGRSLTLRPEGT- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 135 pssltdlceVPFARYLAMNK---VKKMKRYHVGKVWRRESPsivQ-GRYREFCQCDFDIAGQFDPMIpDAECLKIMCEIL 210
Cdd:COG0124    83 ---------APVARAVAEHGnelPFPFKLYYIGPVFRYERP---QkGRYRQFHQFGVEVIGSDSPLA-DAEVIALAADLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 211 SGLQLGDFLIKVNDRrivdgmfaacGVPESKFRAICSSIDKLDKMAWKDVrhemvakkgLAPEVADRIG-----DYVQCH 285
Cdd:COG0124   150 KALGLKDFTLEINSR----------GLPEERAEALLRYLDKLDKIGHEDV---------LDEDSQRRLEtnplrAILDSK 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 286 GGV--SLVEQMfqdPRLSQNKqALEGLEDLKLLFEYLNLFGIaeKISFDLSLARGLDYYTGVIYEAVLLQTPTQageepl 363
Cdd:COG0124   211 GPDcqEVLADA---PKLLDYL-GEEGLAHFEEVLELLDALGI--PYVIDPRLVRGLDYYTGTVFEIVTDGLGAQ------ 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 364 nvGSVAAGGRYDGLVGMFDpkGHKVPCVGLSIGVERIFYIVEQRmktKGEKVRTTETQVFVATPQKNFLQERLKLITELW 443
Cdd:COG0124   279 --GSVCGGGRYDGLVEQLG--GPPTPAVGFAIGLERLLLLLEEL---GLLPAAEPPPDVYVVPLGEEARAEALKLAQELR 351

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622947310 444 DAGIKAEMLYKNNpKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREEVS 499
Cdd:COG0124   352 AAGIRVELDLGGR-KLKKQLKYADKSGAPFVLILGEDELANGTVTLKDLATGEQET 406
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 71-405 8.58e-96

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 292.58  E-value: 8.58e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  71 MVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSG-LMYDLKDQGGELLSLRYDLTypssltdlceVPFARY 149
Cdd:cd00773     2 AALRRYIEDTLREVFERYGYEEIDTPVFEYTELFLRKSGDEVSkEMYRFKDKGGRDLALRPDLT----------APVARA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 150 LAMNKVKK---MKRYHVGKVWRRESPSivQGRYREFCQCDFDIAGqFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRR 226
Cdd:cd00773    72 VAENLLSLplpLKLYYIGPVFRYERPQ--KGRYREFYQVGVEIIG-SDSPLADAEVIALAVEILEALGLKDFQIKINHRG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 227 IVDGmfaACGVPESKFRAICSSIDKLDKmawkdvrhemvakkglapevadrigdyvqchggvslveqmfqdprlsqnkqa 306
Cdd:cd00773   149 ILDG---IAGLLEDREEYIERLIDKLDK---------------------------------------------------- 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 307 lEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVLLQTPTQageeplnvGSVAAGGRYDGLVGMFDpkGH 386
Cdd:cd00773   174 -EALAHLEKLLDYLEALGVDIKYSIDLSLVRGLDYYTGIVFEAVADGLGAQ--------GSIAGGGRYDGLLEEFG--GE 242

                         330
                  ....*....|....*....
gi 1622947310 387 KVPCVGLSIGVERIFYIVE 405
Cdd:cd00773   243 DVPAVGFAIGLERLLLALE 261
hisS TIGR00442
histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed ...
 58-499 2.91e-92

histidyl-tRNA synthetase; This model finds a histidyl-tRNA synthetase in every completed genome. Apparent second copies from Bacillus subtilis, Synechocystis sp., and Aquifex aeolicus are slightly shorter, more closely related to each other than to other hisS proteins, and actually serve as regulatory subunits for an enzyme of histidine biosynthesis. They were excluded from the seed alignment and score much lower than do single copy histidyl-tRNA synthetases of other genomes not included in the seed alignment. These putative second copies of HisS score below the trusted cutoff. The regulatory protein kinase GCN2 of Saccharomyces cerevisiae (YDR283c), and related proteins from other species designated eIF-2 alpha kinase, have a domain closely related to histidyl-tRNA synthetase that may serve to detect and respond to uncharged tRNA(his), an indicator of amino acid starvation; these regulatory proteins are not orthologous and so score below the noise cutoff. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273080 [Multi-domain]  Cd Length: 404  Bit Score: 288.61  E-value: 2.91e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  58 KIPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGL----MYDLKDQGGELLSLRYDLT 133
Cdd:TIGR00442   1 QKPRGTRDFLPEEMIKWQYIEETIREVFERYGFKEIRTPIFEYTELFKRKVGEETDIvskeMYTFKDKGGRSLTLRPEGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 134 ypssltdlceVPFARYLAMNK---VKKMKRYHVGKVWRRESPsivQ-GRYREFCQCDFDIAGQFDPMIpDAECLKIMCEI 209
Cdd:TIGR00442  81 ----------APVARAVIENKlllPKPFKLYYIGPMFRYERP---QkGRYRQFHQFGVEVIGSDSPLA-DAEIIALAADI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 210 LSGLQLGDFLIKVNDRRIVDGMFAacgvpesKFRAICSSIDK-LDKMAWKDVRHEMVAKKGLAPEVADRIGDYVQchggv 288
Cdd:TIGR00442 147 LKELGLKDFTLEINSLGILEGRLE-------YREALIRYLDKhKDKLGEDSVRRLEKNPLRILDSKNEKIQELLK----- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 289 slveqmfQDPRLSQNKQAlEGLEDLKLLFEYLNLFGIaeKISFDLSLARGLDYYTGVIYEAVLLQTPTQageeplnvGSV 368
Cdd:TIGR00442 215 -------NAPKILDFLCE-ESRAHFEELKELLDALGI--PYKIDPSLVRGLDYYTGTVFEFVTDDLGAQ--------GSI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 369 AAGGRYDGLVGMFDpkGHKVPCVGLSIGVERIFYIVEQRmktKGEKVRTTETQVFVATPQKNFLQERLKLITELWDAGIK 448
Cdd:TIGR00442 277 CGGGRYDGLVEELG--GPPTPAVGFAIGIERLILLLEEL---GLIPPPSKKPDVYVVPLGEEAELEALKLAQKLRKAGIR 351

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622947310 449 AEMLYKNNpKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREEVS 499
Cdd:TIGR00442 352 VEVDLGGR-KLKKQLKYADKLGARFALIIGEDELENGTVTLKDLETGEQET 401
PRK12420 PRK12420
histidyl-tRNA synthetase; Provisional
 61-498 2.48e-80

histidyl-tRNA synthetase; Provisional


Pssm-ID: 237097 [Multi-domain]  Cd Length: 423  Bit Score: 258.12  E-value: 2.48e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  61 KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYG---EDSGLMYDLKDQGGELLSLRYDLTypss 137
Cdd:PRK12420    8 KGTKDYLPEEQVLRNKIKRALEDVFERYGCKPLETPTLNMYELMSSKYGggdEILKEIYTLTDQGKRDLALRYDLT---- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 138 ltdlceVPFARYLAMNKVKKM--KRYHVGKVWRrESPsIVQGRYREFCQCDFDIAGQFDPMiPDAECLKIMCEILSGLQL 215
Cdd:PRK12420   84 ------IPFAKVVAMNPNIRLpfKRYEIGKVFR-DGP-IKQGRFREFIQCDVDIVGVESVM-AEAELMSMAFELFRRLNL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 216 gDFLIKVNDRRIVDGMFAACGVPESKFRAICSSIDKLDKMAWKDVRHEmVAKKGLAPEVADRIGDYVQCHGGVSLVEqmF 295
Cdd:PRK12420  155 -EVTIQYNNRKLLNGILQAIGIPTELTSDVILSLDKIEKIGIDGVRKD-LLERGISEEMADTICNTVLSCLQLSIAD--F 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 296 QDPRLSQNKQalEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVLlqtptqagEEPLNVGSVAAGGRYD 375
Cdd:PRK12420  231 KEAFNNPLVA--EGVNELQQLQQYLIALGINENCIFNPFLARGLTMYTGTVYEIFL--------KDGSITSSIGSGGRYD 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 376 GLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRmktkgekVRTTETQVFVATPQKNFLQERLKLITELWDAGIKAEMLYKN 455
Cdd:PRK12420  301 NIIGAFRGDDMNYPTVGISFGLDVIYTALSQK-------ETISSTADVFIIPLGTELQCLQIAQQLRSTTGLKVELELAG 373

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1622947310 456 NpKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREEV 498
Cdd:PRK12420  374 R-KLKKALNYANKENIPYVLIIGEEEVSTGTVMLRNMKEGSEV 415
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 64-400 1.58e-49

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 173.57  E-value: 1.58e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  64 RDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTYP------SS 137
Cdd:TIGR00443   1 RDLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTLSAGSGILNEDLFKLFDQLGRVLGLRPDMTAPiarlvsTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 138 LTDlCEVPFarylamnkvkkmKRYHVGKVWRRESPSIvqGRYREFCQCDFDIAGQfDPMIPDAECLKIMCEILSGLQLGD 217
Cdd:TIGR00443  81 LRD-RPLPL------------RLCYAGNVFRTNESGG--GRSREFTQAGVELIGA-GGPAADAEVIALLIEALKALGLKD 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 218 FLIKVNDRRIVDGMFAACGVPESKFRAICSSIDKLDKMAWKdvrhEMVAKKGLAPEVADRIGDYVQCHGGVSLVEQMFQd 297
Cdd:TIGR00443 145 FKIELGHVGLVRALLEEAGLPEEAREALREALARKDLVALE----ELVAELGLSPEVRERLLALPRLRGDGEEVLEEAR- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 298 pRLSQNKQALEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVLlqtpTQAGEeplnvgSVAAGGRYDGL 377
Cdd:TIGR00443 220 -ALAGSETAEAALDELEAVLELLEARGVEEYISLDLGLVRGYHYYTGLIFEGYA----PGLGA------PLAGGGRYDEL 288

                         330       340
                  ....*....|....*....|...
gi 1622947310 378 VGMFdpkGHKVPCVGLSIGVERI 400
Cdd:TIGR00443 289 LGRF---GRPLPATGFALNLERL 308
PLN02530 PLN02530
histidine-tRNA ligase
 2-499 2.47e-48

histidine-tRNA ligase


Pssm-ID: 178145 [Multi-domain]  Cd Length: 487  Bit Score: 174.93  E-value: 2.47e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310   2 PLLGLLPRRAWAALLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAhqeKPNFIIKIPKGTRDLSPQHMVVREKILDLV 81
Cdd:PLN02530   18 PSLPLSSRCSFLLSASSPRGGRCAASAAAGGGRSGGTTAPPSVQEDG---KPKIDVNPPKGTRDFPPEDMRLRNWLFDHF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  82 ISCFKRHGAKGMDTPAFELKETLTEKYGED-SGLMYDLKDQGGELLSLRYDLTyPSsltdlcevpFARyLAMNKVKKM-- 158
Cdd:PLN02530   95 REVSRLFGFEEVDAPVLESEELYIRKAGEEiTDQLYNFEDKGGRRVALRPELT-PS---------LAR-LVLQKGKSLsl 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 159 --KRYHVGKVWRRESpsIVQGRYREFCQCDFDIAGqFDPMIPDAECLKIMCEILS--GLQLGDFLIKVNDRRIVDGMFAA 234
Cdd:PLN02530  164 plKWFAIGQCWRYER--MTRGRRREHYQWNMDIIG-VPGVEAEAELLAAIVTFFKrvGITSSDVGIKVSSRKVLQAVLKS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 235 CGVPESKFRAICSSIDKLDKMAWKDVRHEMvAKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPrlsqnkqalEGLEDLK 314
Cdd:PLN02530  241 YGIPEESFAPVCVIVDKLEKLPREEIEKEL-DTLGVSEEAIEGILDVLSLKSLDDLEALLGADS---------EAVADLK 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 315 LLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVllqtpTQAGEeplnVGSVAAGGRYDGLVGMFDpkGHKVPCVGLS 394
Cdd:PLN02530  311 QLFSLAEAYGYQDWLVFDASVVRGLAYYTGIVFEGF-----DRAGK----LRAICGGGRYDRLLSTFG--GEDTPACGFG 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 395 IG--VerifyIVEQrMKTKG---EKVRTTETQVFvatPQKNFLQ-ERLKLITELWDAGIKAEMLYKNNpKLLTQLHYCES 468
Cdd:PLN02530  380 FGdaV-----IVEL-LKEKGllpELPHQVDDVVF---ALDEDLQgAAAGVASRLREKGRSVDLVLEPK-KLKWVFKHAER 449

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1622947310 469 TGIPLVVIIGEQELKEGIIKIRSVASREEVS 499
Cdd:PLN02530  450 IGAKRLVLVGASEWERGMVRVKDLSSGEQTE 480
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
74-400 2.69e-44

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 159.19  E-value: 2.69e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  74 REKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGL-MYDLKDQGGELLSLRYDLTypssltdlceVPFARYLA- 151
Cdd:COG3705     8 KEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADLDLqTFKLVDQLGRTLGLRPDMT----------PQVARIAAt 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 152 -MNKVKKMKRY-HVGKVWRRESPSivQGRYREFCQC------DFDIAGqfdpmipDAECLKIMCEILSGLQLGDFLIKVN 223
Cdd:COG3705    78 rLANRPGPLRLcYAGNVFRTRPSG--LGRSREFLQAgaeligHAGLEA-------DAEVIALALEALKAAGLEDFTLDLG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 224 DRRIVDGMFAACGVPESKFRAICSSIDKLDkmaWKDVRhEMVAKKGLAPEVADRIGDYVQCHGGVSLVEQMFQdprLSQN 303
Cdd:COG3705   149 HVGLFRALLEALGLSEEQREELRRALARKD---AVELE-ELLAELGLSEELAEALLALPELYGGEEVLARARA---LLLD 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 304 KQALEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVllqTPTQAGEeplnvgsVAAGGRYDGLVGMFdp 383
Cdd:COG3705   222 AAIRAALDELEALAEALAARGPDVRLTFDLSELRGYDYYTGIVFEAY---APGVGDP-------LARGGRYDGLLAAF-- 289

                         330
                  ....*....|....*..
gi 1622947310 384 kGHKVPCVGLSIGVERI 400
Cdd:COG3705   290 -GRARPATGFSLDLDRL 305
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 59-451 5.33e-43

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 158.11  E-value: 5.33e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  59 IPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGL-MYDLKDQG-GELLSLRYDLTyps 136
Cdd:PRK12292    5 LPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGAILDLrTFKLVDQLsGRTLGLRPDMT--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 137 sltdlceVPFARyLAMNKVKKMKR-----YHvGKVWR-RESPSivqGRYREFCQCDFDIAGqFDPMIPDAECLKIMCEIL 210
Cdd:PRK12292   82 -------AQIAR-IAATRLANRPGplrlcYA-GNVFRaQERGL---GRSREFLQSGVELIG-DAGLEADAEVILLLLEAL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 211 SGLQLGDFLIKVNDRRIVDGMFAACGVPESKFRAICSSIDKLDKMAWKdvrhEMVAkkGLAPEVADRIGDYVQCHGGVSL 290
Cdd:PRK12292  149 KALGLPNFTLDLGHVGLFRALLEAAGLSEELEEVLRRALANKDYVALE----ELVL--DLSEELRDALLALPRLRGGREV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 291 VEQMfqdPRLSQNKQALEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVllqtptqAGEEPLNVGSvaa 370
Cdd:PRK12292  223 LEEA---RKLLPSLPIKRALDELEALAEALEKYGYGIPLSLDLGLLRHLDYYTGIVFEGY-------VDGVGNPIAS--- 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 371 GGRYDGLVGMFdpkGHKVPCVGLSIGVERifyIVEQRMKTKgekvrTTETQVFVATPQKNFLQERLKLITELWDAGIKAE 450
Cdd:PRK12292  290 GGRYDDLLGRF---GRARPATGFSLDLDR---LLELQLELP-----VEARKDLVIAPDSEALAAALAAAQELRKKGEIVV 358


                  .
gi 1622947310 451 M 451
Cdd:PRK12292  359 L 359
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 62-400 2.89e-39

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 145.42  E-value: 2.89e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  62 GTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTyPSsltdl 141
Cdd:pfam13393   1 GIRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLDQTFKLVDQSGRLLGLRADIT-PQ----- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 142 cevpFARYLA--MNKVKKMKRYHVGKVWRRESPSIvqGRYREFCQCDFDIAGQFDPMiPDAECLKIMCEILSGLQLGDFL 219
Cdd:pfam13393  75 ----VARIDAhrLNRPGPLRLCYAGSVLRTRPKGL--GRSREPLQVGAELIGHAGIE-ADAEIISLLLEALAAAGVPGVT 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 220 IKVNDRRIVDGMFAACGVPESKFRAICSSIDKLDkmaWKDVRhEMVAKKGLAPEVADRIGDYVQCHGGVSLVEQMFQdpR 299
Cdd:pfam13393 148 LDLGHVGLVRALLEAAGLSEALEEALRAALQRKD---AAELA-ELAAEAGLPPALRRALLALPDLYGGPEVLDEARA--A 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 300 LSQNKQALEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLDYYTGVIYEAVLLQTPtqageeplnvGSVAAGGRYDGLVG 379
Cdd:pfam13393 222 LPGLPALQEALDELEALAALLEALGDGVRLTFDLAELRGYEYYTGIVFAAYAPGVG----------EPLARGGRYDDLGA 291

                         330       340
                  ....*....|....*....|.
gi 1622947310 380 MFdpkGHKVPCVGLSIGVERI 400
Cdd:pfam13393 292 AF---GRARPATGFSLDLEAL 309
syh CHL00201
histidine-tRNA synthetase; Provisional
 61-497 7.05e-25

histidine-tRNA synthetase; Provisional


Pssm-ID: 164576 [Multi-domain]  Cd Length: 430  Bit Score: 107.29  E-value: 7.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  61 KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGL----MYDLKDQGGELLSLRYDLTyps 136
Cdd:CHL00201    8 RGTKDILPDEINYWQFIHDKALTLLSLANYSEIRTPIFENSSLYDRGIGETTDIvnkeMYRFTDRSNRDITLRPEGT--- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 137 sltdlceVPFARYLAMNKVKKMKR----YHVGKVWRRESPSivQGRYREFCQCDFDIAGQFDPMiPDAECLKIMCEILSG 212
Cdd:CHL00201   85 -------AGIVRAFIENKMDYHSNlqrlWYSGPMFRYERPQ--SGRQRQFHQLGIEFIGSIDAR-ADTEVIHLAMQIFNE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 213 LQLGDFLIKVN------DRRIVdgmfaacgvpESKFRAICSSI-DKLDKmawkDVRHEMVAKkglaP-EVADRIGDYVQc 284
Cdd:CHL00201  155 LQVKNLILDINsigkleDRQSY----------QLKLVEYLSQYqDDLDT----DSQNRLYSN----PiRILDSKNLKTQ- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 285 hggvslvEQMFQDPRLSqNKQALEGLEDLKLLFEYLNLFGIAEKISFdlSLARGLDYYTGVIYEavlLQTPTQAGEEpln 364
Cdd:CHL00201  216 -------EILDGAPKIS-DFLSLESTEHFYDVCTYLNLLNIPYKINY--KLVRGLDYYNDTAFE---IKTLSSNGQD--- 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 365 vgSVAAGGRYDGLVGMFDpkGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVrttetQVFVATPQKNFLQERLKLITELWD 444
Cdd:CHL00201  280 --TICGGGRYDSLIHQLG--GPKTPAVGCAIGLERLLLIAKDNIILPKQSI-----DVYIATQGLKAQKKGWEIIQFLEK 350

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622947310 445 AGIKAEmLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREE 497
Cdd:CHL00201  351 QNIKFE-LDLSSSNFHKQIKQAGKKRAKACIILGDNEIMDNCITIKWLDEQVQ 402
HisRS_anticodon cd00859
HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases ...
 419-499 1.59e-24

HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.


Pssm-ID: 238436 [Multi-domain]  Cd Length: 91  Bit Score: 97.61  E-value: 1.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 419 ETQVFVATPQKNFLQERLKLITELWDAGIKAEMLYKNnPKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREEV 498
Cdd:cd00859     1 EVDVYVVPLGEGALSEALELAEQLRDAGIKAEIDYGG-RKLKKQFKYADRSGARFAVILGEDELAAGVVTVKDLETGEQE 79


                  .
gi 1622947310 499 S 499
Cdd:cd00859    80 T 80
hisZ PRK12295
ATP phosphoribosyltransferase regulatory subunit; Provisional
 77-400 3.85e-19

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183413 [Multi-domain]  Cd Length: 373  Bit Score: 89.22  E-value: 3.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310  77 ILDLVISCFKRHGAKGMDTPAFELKETLTEKYGED-SGLMYDLKDQGGELLSLRYDLTYPSSLtdlcevpfaRYLAMNKV 155
Cdd:PRK12295   10 AAEALLASFEAAGAVRVDPPILQPAEPFLDLSGEDiRRRIFVTSDENGEELCLRPDFTIPVCR---------RHIATAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 156 KKMKRYHVGKVWRRESpsivqGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAAC 235
Cdd:PRK12295   81 EPARYAYLGEVFRQRR-----DRASEFLQAGIESFGRADPAAADAEVLALALEALAALGPGDLEVRLGDVGLFAALVDAL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 236 GVPE-------------SKFRAIcssIDKL-------------------DKMAWKDVRHEMVAKKGLAP-------EVAD 276
Cdd:PRK12295  156 GLPPgwkrrllrhfgrpRSLDAL---LARLagprvdpldehagvlaalaDEAAARALVEDLMSIAGISPvggrspaEIAR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 277 RIGDYVQCHGGVSLVEQMFQ----------DPrlsqnKQALEGLEDL----KL-LFEYLNLF----------GIA-EKIS 330
Cdd:PRK12295  233 RLLEKAALAAAARLPAEALAvlerflaisgPP-----DAALAALRALaadaGLdLDAALDRFearlaalaarGIDlERLR 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 331 FDLSLARGLDYYTGVIYEAvllqTPTQAGEEPLnvgsvAAGGRYDGLVGMFDpKGHKVPCVGLSIGVERI 400
Cdd:PRK12295  308 FSASFGRPLDYYTGFVFEI----RAAGNGDPPL-----AGGGRYDGLLTRLG-AGEPIPAVGFSIWLDRL 367
HGTP_anticodon pfam03129
Anticodon binding domain; This domain is found in histidyl, glycyl, threonyl and prolyl tRNA ...
 421-509 3.18e-14

Anticodon binding domain; This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases it is probably the anticodon binding domain.


Pssm-ID: 460819 [Multi-domain]  Cd Length: 94  Bit Score: 68.38  E-value: 3.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 421 QVFVATPQKN---FLQERLKLITELWDAGIKAEmLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGIIKIRSVASREE 497
Cdd:pfam03129   1 QVVVIPLGEKaeeLEEYAQKLAEELRAAGIRVE-LDDRNESIGKKFRRADLIGIPFALVVGEKELEEGTVTVRRRDTGEQ 79

                          90
                  ....*....|..
gi 1622947310 498 VSGSsrnrRDEL 509
Cdd:pfam03129  80 ETVS----LDEL 87
PRK12421 PRK12421
ATP phosphoribosyltransferase regulatory subunit; Provisional
 262-400 1.22e-05

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237098  Cd Length: 392  Bit Score: 47.66  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 262 HEMVAKKGLAPEVADRIGDYVQCHGGV-SLVEQMFQDPRlsQNKQALEGLEDLKLLFEYLNLFGIAEKISFDLSLARGLD 340
Cdd:PRK12421  199 AEVCQNLGVGSDLRRMFYALARLNGGLeALDRALSVLAL--QDAAIRQALDELKTLAAHLKNRWPELPVSIDLAELRGYH 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 341 YYTGVIYeAVLLQTPTQAgeeplnvgsVAAGGRYDGLVGMFdpkGHKVPCVGLSIGVERI 400
Cdd:PRK12421  277 YHTGLVF-AAYIPGRGQA---------LARGGRYDGIGEAF---GRARPATGFSMDLKEL 323
HGTP_anticodon2 pfam12745
Anticodon binding domain of tRNAs; This is an HGTP_anticodon binding domain, found largely on ...
 422-498 1.01e-04

Anticodon binding domain of tRNAs; This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations.


Pssm-ID: 432758  Cd Length: 259  Bit Score: 44.13  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947310 422 VFVATPQKNFL-QERLKLITELWDAGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQEL----KEGIIKIRSVASRE 496
Cdd:pfam12745   8 VLVASFDASILrTTGVEILQELWAHGISADLAVDASYSPEDLVSRARDDGVSWIVIIKQQNKssdsKYKPLKVKNLLRKE 87


                  ..
gi 1622947310 497 EV 498
Cdd:pfam12745  88 DV 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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