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Conserved domains on  [gi|1622913461|ref|XP_028696823|]
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intraflagellar transport protein 140 homolog isoform X2 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 18610525)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 824-1082 1.18e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 1.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  824 LGNMGHARG--ARALRE----AEREPE-LEARV--AVLATQLGMLEDAEQLYRKCKRYD--------LLNRFYQAAGQWQ 886
Cdd:COG2956     48 LGNLYRRRGeyDRAIRIhqklLERDPDrAEALLelAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWE 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  887 KALKVAERHDRVHLRSTYHHY--AGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQY 964
Cdd:COG2956    128 KAIEVLERLLKLGPENAHAYCelAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AEL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  965 LESQGEMDAALHYYelaqdhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknair 1044
Cdd:COG2956    188 YLEQGDYEEAIAAL-------------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE------ 240

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1622913461 1045 lckENSLDDQLMNLALLSSPEDMIEAARYYEEKGMQMD 1082
Cdd:COG2956    241 ---LDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 3.19e-08

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKEQ 95
Cdd:COG2319    286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1622913461   96 HTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319    365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.72e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  973 AALHYYELAQDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956      7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1048 ENslDDQLMNLAllsspedmieaaryyeekgmqmdravMLYHKAGHFSKALELafttqqfaALQLIAEDLDetsDPALLA 1127
Cdd:COG2956     74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1128 RCSDFFIEHRQYERAVELLLAARKYRealqlclEQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIANCCMR---- 1201
Cdd:COG2956    115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                          250       260
                   ....*....|....*....|....*.
gi 1622913461 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956    184 LAELYLEQGDYEEA---IAALERALE 206
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 824-1082 1.18e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 1.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  824 LGNMGHARG--ARALRE----AEREPE-LEARV--AVLATQLGMLEDAEQLYRKCKRYD--------LLNRFYQAAGQWQ 886
Cdd:COG2956     48 LGNLYRRRGeyDRAIRIhqklLERDPDrAEALLelAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWE 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  887 KALKVAERHDRVHLRSTYHHY--AGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQY 964
Cdd:COG2956    128 KAIEVLERLLKLGPENAHAYCelAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AEL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  965 LESQGEMDAALHYYelaqdhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknair 1044
Cdd:COG2956    188 YLEQGDYEEAIAAL-------------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE------ 240

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1622913461 1045 lckENSLDDQLMNLALLSSPEDMIEAARYYEEKGMQMD 1082
Cdd:COG2956    241 ---LDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 3.19e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKEQ 95
Cdd:COG2319    286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1622913461   96 HTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319    365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-167 2.99e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 2.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   15 AGSPSHISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDK 93
Cdd:cd00200     51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622913461   94 EQHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKPLTHCIFRlpPPGEDLV 167
Cdd:cd00200    126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL 193
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 833-1233 3.44e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  833 ARALREAEREPELEARVAVLATQLGM--------------LEDAEQLYRKCKRYDLLNRF-YQAAGQWQKALKVAERhdr 897
Cdd:TIGR02917  380 EKAAEYLAKATELDPENAAARTQLGIsklsqgdpseaiadLETAAQLDPELGRADLLLILsYLRSGQFDKALAAAKK--- 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  898 vhLR-------STYHHYAGHLEASADCSRALSYYEKSdthrfevprmLS---EDLPSL-ELyvnkmkdktlwrwwAQYLE 966
Cdd:TIGR02917  457 --LEkkqpdnaSLHNLLGAIYLGKGDLAKAREAFEKA----------LSiepDFFPAAaNL--------------ARIDI 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  967 SQGEMDAALHYYElaqdhfSLVRIHcfqgnvqkaaqianeTGNLAASYHLARQYESQEEVGQAVHFYTRA-----QAFKN 1041
Cdd:TIGR02917  511 QEGNPDDAIQRFE------KVLTID---------------PKNLRAILALAGLYLRTGNEEEAVAWLEKAaelnpQEIEP 569

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1042 AIRLCKENSLDDQLMN-LALLSSPEDMI-EAARYYEEKGMqmdravmLYHKAGHFSKALElAFTtqqfaalQLIAEDLDE 1119
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKaLAILNEAADAApDSPEAWLMLGR-------AQLAAGDLNKAVS-SFK-------KLLALQPDS 634

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1120 tsdPALLARCSDFFIEHRQYERAvelllaARKYREALQL----CLEQNMSITEEMAEKMTV-AKDSSDLPEESRRE---L 1191
Cdd:TIGR02917  635 ---ALALLLLADAYAVMKNYAKA------ITSLKRALELkpdnTEAQIGLAQLLLAAKRTEsAKKIAKSLQKQHPKaalG 705

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1622913461 1192 LEQIANCCMRQGSYHLATKKYTQA-------GNKLKAMRALLKSGDTEK 1233
Cdd:TIGR02917  706 FELEGDLYLRQKDYPAAIQAYRKAlkrapssQNAIKLHRALLASGNTAE 754
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.72e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  973 AALHYYELAQDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956      7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1048 ENslDDQLMNLAllsspedmieaaryyeekgmqmdravMLYHKAGHFSKALELafttqqfaALQLIAEDLDetsDPALLA 1127
Cdd:COG2956     74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1128 RCSDFFIEHRQYERAVELLLAARKYRealqlclEQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIANCCMR---- 1201
Cdd:COG2956    115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                          250       260
                   ....*....|....*....|....*.
gi 1622913461 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956    184 LAELYLEQGDYEEA---IAALERALE 206
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 824-1082 1.18e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 1.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  824 LGNMGHARG--ARALRE----AEREPE-LEARV--AVLATQLGMLEDAEQLYRKCKRYD--------LLNRFYQAAGQWQ 886
Cdd:COG2956     48 LGNLYRRRGeyDRAIRIhqklLERDPDrAEALLelAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWE 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  887 KALKVAERHDRVHLRSTYHHY--AGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQY 964
Cdd:COG2956    128 KAIEVLERLLKLGPENAHAYCelAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AEL 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  965 LESQGEMDAALHYYelaqdhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknair 1044
Cdd:COG2956    188 YLEQGDYEEAIAAL-------------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE------ 240

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1622913461 1045 lckENSLDDQLMNLALLSSPEDMIEAARYYEEKGMQMD 1082
Cdd:COG2956    241 ---LDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 3.19e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKEQ 95
Cdd:COG2319    286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1622913461   96 HTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319    365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 877-1149 1.64e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  877 RFYQAAGQWQKALKVAERHDRVHLRSTYHHYA-GHL-EASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkd 954
Cdd:COG2956     16 LNYLLNGQPDKAIDLLEEALELDPETVEAHLAlGNLyRRRGEYDRAIRIHQK----------LLERDPDRAEALLEL--- 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  955 ktlwrwwAQYLESQGEMDAALHYYELAQD--------HFSLVRIHCFQGNVQKAAQIANE-----TGNLAASYHLARQYE 1021
Cdd:COG2956     83 -------AQDYLKAGLLDRAEELLEKLLEldpddaeaLRLLAEIYEQEGDWEKAIEVLERllklgPENAHAYCELAELYL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1022 SQEEVGQAVHFYTRA-QAFKNAIRLckenslddqLMNLA-LLSSPEDMIEAARYYEEKGMQMDRAVMLYHKAGHFSKALE 1099
Cdd:COG2956    156 EQGDYDEAIEALEKAlKLDPDCARA---------LLLLAeLYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLG 226

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1100 lafttQQFAALQLIAEDLDETSDPALLARCSDFFIEHRQYERAVELLLAA 1149
Cdd:COG2956    227 -----DPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
WD40 COG2319
WD40 repeat [General function prediction only];
16-139 3.11e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 3.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   16 GSPSHISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKE 94
Cdd:COG2319    247 GSVRSVAFSPDGRLLA----SGSADGTVRLWdLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622913461   95 QHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319    322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-167 2.99e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 2.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   15 AGSPSHISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDK 93
Cdd:cd00200     51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622913461   94 EQHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKPLTHCIFRlpPPGEDLV 167
Cdd:cd00200    126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL 193
WD40 COG2319
WD40 repeat [General function prediction only];
16-140 5.66e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 5.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   16 GSPSHISWHPVHPFLAVAyistTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKE 94
Cdd:COG2319    205 GAVRSVAFSPDGKLLASG----SADGTVRLWdLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622913461   95 QHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQRGRVQG 140
Cdd:COG2319    280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-139 3.11e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 3.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   16 GSPSHISWHPVHPFLAVAyistTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKE 94
Cdd:cd00200    136 DWVNSVAFSPDGTFVASS----SQDGTIKLWdLRTGKCV-ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622913461   95 QHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:cd00200    211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 833-1233 3.44e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  833 ARALREAEREPELEARVAVLATQLGM--------------LEDAEQLYRKCKRYDLLNRF-YQAAGQWQKALKVAERhdr 897
Cdd:TIGR02917  380 EKAAEYLAKATELDPENAAARTQLGIsklsqgdpseaiadLETAAQLDPELGRADLLLILsYLRSGQFDKALAAAKK--- 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  898 vhLR-------STYHHYAGHLEASADCSRALSYYEKSdthrfevprmLS---EDLPSL-ELyvnkmkdktlwrwwAQYLE 966
Cdd:TIGR02917  457 --LEkkqpdnaSLHNLLGAIYLGKGDLAKAREAFEKA----------LSiepDFFPAAaNL--------------ARIDI 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  967 SQGEMDAALHYYElaqdhfSLVRIHcfqgnvqkaaqianeTGNLAASYHLARQYESQEEVGQAVHFYTRA-----QAFKN 1041
Cdd:TIGR02917  511 QEGNPDDAIQRFE------KVLTID---------------PKNLRAILALAGLYLRTGNEEEAVAWLEKAaelnpQEIEP 569

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1042 AIRLCKENSLDDQLMN-LALLSSPEDMI-EAARYYEEKGMqmdravmLYHKAGHFSKALElAFTtqqfaalQLIAEDLDE 1119
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKaLAILNEAADAApDSPEAWLMLGR-------AQLAAGDLNKAVS-SFK-------KLLALQPDS 634

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1120 tsdPALLARCSDFFIEHRQYERAvelllaARKYREALQL----CLEQNMSITEEMAEKMTV-AKDSSDLPEESRRE---L 1191
Cdd:TIGR02917  635 ---ALALLLLADAYAVMKNYAKA------ITSLKRALELkpdnTEAQIGLAQLLLAAKRTEsAKKIAKSLQKQHPKaalG 705

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1622913461 1192 LEQIANCCMRQGSYHLATKKYTQA-------GNKLKAMRALLKSGDTEK 1233
Cdd:TIGR02917  706 FELEGDLYLRQKDYPAAIQAYRKAlkrapssQNAIKLHRALLASGNTAE 754
WD40 COG2319
WD40 repeat [General function prediction only];
35-139 4.08e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 4.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   35 ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKEQHTTPPTHTADIAVLSWSP 113
Cdd:COG2319     94 ASASADGTVRLWdLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                           90       100
                   ....*....|....*....|....*.
gi 1622913461  114 SGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319    173 DGKLLASGSDDGTVRLWDLATGKLLR 198
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 5.11e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 5.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   14 AAGSPSHISWHPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEV 85
Cdd:COG2319    108 ATGLLLRTLTGHTGAVRSVAFspdgktlASGSADGTVRLWdLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622913461   86 TVFNKQDKEQHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319    187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
860-1076 5.32e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 5.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  860 EDAEQLYRKCKRYDLLNRFYQAAGQWQKALKVAERHDRVH-LRSTYHHYAGHLEasadcsRALSYYEKsdthrfevprml 938
Cdd:COG0457      6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALyNLGLAYLRLGRYE------EALADYEQ------------ 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  939 sedlpSLELYVNkmkDKTLWRWWAQYLESQGEMDAALHYYE--------LAQDHFSLVRIHCFQGNVQKAAQ-----IAN 1005
Cdd:COG0457     68 -----ALELDPD---DAEALNNLGLALQALGRYEEALEDYDkaleldpdDAEALYNLGLALLELGRYDEAIEayeraLEL 139

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622913461 1006 ETGNLAASYHLARQYESQEEVGQAVHFYTRAQAFKNAIRLCKENSLDDQLMNLALLSSPEDMIEAARYYEE 1076
Cdd:COG0457    140 DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKK 210
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 785-894 6.64e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 6.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  785 IGDMDEAFKSI-KLIKSE----AVWENMARMCVKTQRLDVAKVCLgnmghargARALREAEREPELEARVAVLATQLGML 859
Cdd:COG4783     17 AGDYDEAEALLeKALELDpdnpEAFALLGEILLQLGDLDEAIVLL--------HEALELDPDEPEARLNLGLALLKAGDY 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1622913461  860 EDAEQLYRKCKR--------YDLLNRFYQAAGQWQKALKVAER 894
Cdd:COG4783     89 DEALALLEKALKldpehpeaYLRLARAYRALGRPDEAIAALEK 131
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 1.41e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   14 AAGSPSHISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDK 93
Cdd:COG2319     31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622913461   94 EQHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-139 4.84e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 4.84e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622913461   63 RVASLCWHPTRPVLAMGWETGEVTVFNKQDKEQHTTPPTHTADIAVLSWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 829-1091 5.94e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 43.75  E-value: 5.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  829 HARGARALRE------AEREPELEARVAVLATQL----GMLEDA----EQLYRKCKR----YDLLNRFYQAAGQWQKALK 890
Cdd:COG3071     61 QALGDYERRDeylaqaLELAPEAELAVLLTRAELlldqGQAEQAlatlEALRAGAPRhpqvLRLLLQAYRQLGDWEELLE 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  891 VAER------HDRVHLRSTYHH-YAGHLEASADCSRALsyyeksdthrfevpRMLSEDLPSLElyvnkMKDKTLWRWWAQ 963
Cdd:COG3071    141 LLPAlrkhkaLSAEEAQALERRaYLGLLRQAARDAEAL--------------KALWKALPRAE-----RRDPELAAAYAR 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  964 YLESQGEMDAALHYYELAQDHF---SLVRI--HCFQGNVQKAAQIAN-----ETGNLAASYHLARQYESQEEVGQAVHFY 1033
Cdd:COG3071    202 ALIALGDHDEAERLLREALKRQwdpRLVRLygRLQGGDPAKQLKRAEkwlkkHPNDPDLLLALGRLCLRNQLWGKAREYL 281

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622913461 1034 TRAqafknairlckenslddqlmnLALLSSPEDMIEAARYYEEKGmQMDRAVMLYHKA 1091
Cdd:COG3071    282 EAA---------------------LALRPSAEAYAELARLLEQLG-DPEEAAEHYRKA 317
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.72e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  973 AALHYYELAQDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956      7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1048 ENslDDQLMNLAllsspedmieaaryyeekgmqmdravMLYHKAGHFSKALELafttqqfaALQLIAEDLDetsDPALLA 1127
Cdd:COG2956     74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461 1128 RCSDFFIEHRQYERAVELLLAARKYRealqlclEQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIANCCMR---- 1201
Cdd:COG2956    115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                          250       260
                   ....*....|....*....|....*.
gi 1622913461 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956    184 LAELYLEQGDYEEA---IAALERALE 206
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
803-1055 3.10e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  803 VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEREPELEARVAVLATQLGMLEDAEQLYRKCKRYD------LLN 876
Cdd:COG0457     10 AYNNLGLAYRRLGRYEEAIEDY--------EKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpddaeaLNN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  877 R--FYQAAGQWQKALKVAERHDRVH--LRSTYHHYAGHLEASADCSRALSYYEKsdthrfevprmlsedlpSLELyvnKM 952
Cdd:COG0457     82 LglALQALGRYEEALEDYDKALELDpdDAEALYNLGLALLELGRYDEAIEAYER-----------------ALEL---DP 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461  953 KDKTLWRWWAQYLESQGEMDAALHYYELAQDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLARQYESQEEVGQAVHF 1032
Cdd:COG0457    142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221

                          250       260
                   ....*....|....*....|...
gi 1622913461 1033 YTRAQAFKNAIRLCKENSLDDQL 1055
Cdd:COG0457    222 LLLLALALLLALRLAALALYQYR 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-121 6.05e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 6.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622913461   19 SHISWHPVHPFLavayISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRPVLAMGWETGEVTVFNKQDKEQHT 97
Cdd:cd00200    181 NSVAFSPDGEKL----LSSSSDGTIKLWdLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                           90       100
                   ....*....|....*....|....
gi 1622913461   98 TPPTHTADIAVLSWSPSGNCLLSG 121
Cdd:cd00200    256 TLSGHTNSVTSLAWSPDGKRLASG 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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