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Conserved domains on  [gi|1622893351|ref|XP_028694608|]
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zinc finger protein 121 isoform X2 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-375 1.83e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 213 KPYECNECGKAYNRFYLLTEHFKT--HTEE--KPFECKV--CGKSFRSSSCLKNHFRIHTGIKPYKCK--ECGKAFTVSS 284
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 285 ------SLHNHVKIHTgEKPYEC--KDCGKAFATSSQLIEHIRTHTGEKP--YICKECGKTFRASSHLQKHVRIHTgEKP 354
Cdd:COG5048   368 nneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170       180
                  ....*....|....*....|.
gi 1622893351 355 YICNECGKAYNRFYLLTKHLK 375
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-257 5.70e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 114 YSTSHAVSVKVRTVEKPYECKECGKFFRYSSYLNSHMRT--HTGE--KPYECKE--CGKCFTVSSHLVEHVRIHTGEKPY 187
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 188 QCK-------------------------------------ECGRAFAGRSGLTKHVRIHTGEKPYECN--ECGKAYNRFY 228
Cdd:COG5048   353 KEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                         170       180
                  ....*....|....*....|....*....
gi 1622893351 229 LLTEHFKTHTEEKPFECKVCGKSFRSSSC 257
Cdd:COG5048   433 NLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-375 1.83e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 213 KPYECNECGKAYNRFYLLTEHFKT--HTEE--KPFECKV--CGKSFRSSSCLKNHFRIHTGIKPYKCK--ECGKAFTVSS 284
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 285 ------SLHNHVKIHTgEKPYEC--KDCGKAFATSSQLIEHIRTHTGEKP--YICKECGKTFRASSHLQKHVRIHTgEKP 354
Cdd:COG5048   368 nneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170       180
                  ....*....|....*....|.
gi 1622893351 355 YICNECGKAYNRFYLLTKHLK 375
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-257 5.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 114 YSTSHAVSVKVRTVEKPYECKECGKFFRYSSYLNSHMRT--HTGE--KPYECKE--CGKCFTVSSHLVEHVRIHTGEKPY 187
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 188 QCK-------------------------------------ECGRAFAGRSGLTKHVRIHTGEKPYECN--ECGKAYNRFY 228
Cdd:COG5048   353 KEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                         170       180
                  ....*....|....*....|....*....
gi 1622893351 229 LLTEHFKTHTEEKPFECKVCGKSFRSSSC 257
Cdd:COG5048   433 NLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-169 7.86e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.86e-05
                          10        20
                  ....*....|....*....|....*
gi 1622893351 145 YLNSHMRTHTGEKPYECKECGKCFT 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-281 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....
gi 1622893351 258 LKNHFRIHTGIKPYKCKECGKAFT 281
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 298-346 4.40e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622893351 298 PYECKDCGKAFATSSQLIEHIRTHTGEKpyICKECGKTFRASSHLQKHV 346
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-375 1.83e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 213 KPYECNECGKAYNRFYLLTEHFKT--HTEE--KPFECKV--CGKSFRSSSCLKNHFRIHTGIKPYKCK--ECGKAFTVSS 284
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 285 ------SLHNHVKIHTgEKPYEC--KDCGKAFATSSQLIEHIRTHTGEKP--YICKECGKTFRASSHLQKHVRIHTgEKP 354
Cdd:COG5048   368 nneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170       180
                  ....*....|....*....|.
gi 1622893351 355 YICNECGKAYNRFYLLTKHLK 375
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-312 3.85e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 157 KPYECKECGKCFTVSSHLVEHVR--IHTGE--KPYQCKE--CGRAFAGRSGLTKHVRIHTGEKPYECNEC-------GKA 223
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 224 YNRFYLLTEHFKTHTEEKPFECKV--CGKSFRSSSCLKNHFRIHT--GIKPYKCKECGKAFTVSSSLHNHVKIHTGEKPY 299
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|...
gi 1622893351 300 ECKDCGKAFATSS 312
Cdd:COG5048   448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-345 3.96e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 185 KPYQCKECGRAFAGRSGLTKHVR--IHTGE--KPYECNE--CGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCL 258
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 259 KN----HFRIHTGIKPYKCKECGKAFTVS-------SSLHNHVKIHTGEKPYECKDCGKAFATSSQLIEHIRTHTgEKPY 327
Cdd:COG5048   368 NNeppqSLQQYKDLKNDKKSETLSNSCIRnfkrdsnLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                         170
                  ....*....|....*...
gi 1622893351 328 ICKECGKTFRASSHLQKH 345
Cdd:COG5048   447 LLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-257 5.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 114 YSTSHAVSVKVRTVEKPYECKECGKFFRYSSYLNSHMRT--HTGE--KPYECKE--CGKCFTVSSHLVEHVRIHTGEKPY 187
Cdd:COG5048   273 SSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 188 QCK-------------------------------------ECGRAFAGRSGLTKHVRIHTGEKPYECN--ECGKAYNRFY 228
Cdd:COG5048   353 KEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                         170       180
                  ....*....|....*....|....*....
gi 1622893351 229 LLTEHFKTHTEEKPFECKVCGKSFRSSSC 257
Cdd:COG5048   433 NLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-169 7.86e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.86e-05
                          10        20
                  ....*....|....*....|....*
gi 1622893351 145 YLNSHMRTHTGEKPYECKECGKCFT 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-266 3.13e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 157 KPYECKECGKCFTVSSHLVEHVRIHTGEKPYQCKECGRA--FAGRSGLTKHVRIHTGEKPYEC----------------N 218
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622893351 219 ECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCLKNHFRIHT 266
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-281 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....
gi 1622893351 258 LKNHFRIHTGIKPYKCKECGKAFT 281
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-197 5.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.87e-04
                          10        20
                  ....*....|....*....|....*
gi 1622893351 173 HLVEHVRIHTGEKPYQCKECGRAFA 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*
gi 1622893351 202 LTKHVRIHTGEKPYECNECGKAYNR 226
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-310 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|..
gi 1622893351 289 HVKIHTGEKPYECKDCGKAFAT 310
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 3.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622893351 341 HLQKHVRIHTGEKPYICNECGKAYNR 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 299-321 3.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.60e-03
                          10        20
                  ....*....|....*....|...
gi 1622893351 299 YECKDCGKAFATSSQLIEHIRTH 321
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 3.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1622893351 230 LTEHFKTHTEEKPFECKVCGKSFRS 254
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-326 3.90e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 269 KPYKCKECGKAFTVSSSLHNHVKIHTGEKPYECKD--CGKAFATSSQLIEHIRTHTGEKP 326
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 131-153 3.93e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.93e-03
                          10        20
                  ....*....|....*....|...
gi 1622893351 131 YECKECGKFFRYSSYLNSHMRTH 153
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 298-346 4.40e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622893351 298 PYECKDCGKAFATSSQLIEHIRTHTGEKpyICKECGKTFRASSHLQKHV 346
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
PHA00733 PHA00733
hypothetical protein
 242-290 4.66e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 4.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622893351 242 PFECKVCGKSFRSSSCLKNHFRIHTGIKpyKCKECGKAFTVSSSLHNHV 290
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 239-322 5.71e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893351 239 EEKPFECKV--CGKSFRSSSCLKNHfRIHtgikpykcKECGKAFTVSSSLHNHVKIHTGEKPYECKDCGKAFATSSQLIE 316
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1622893351 317 HiRTHT 322
Cdd:COG5189   417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-306 7.20e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 7.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622893351 241 KPFECKVCGKSFRSSSCLKNHFRIHTGIKPYKC--KECGKAFTVSSSLHNHVKIHTGEKPYECKDCGK 306
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-358 8.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622893351 297 KPYECKDCGKAFATSSQLIEHIRTHTGEKPYIC--KECGKTFRASSHLQKHVRIHTGEKPYICN 358
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-377 9.44e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 9.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622893351 325 KPYICKECGKTFRASSHLQKHVRIHTGEKPYICN--ECGKAYNRFYLLTKHLKTH 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 327-349 9.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.89e-03
                          10        20
                  ....*....|....*....|...
gi 1622893351 327 YICKECGKTFRASSHLQKHVRIH 349
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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