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Conserved domains on  [gi|1604835206|ref|XP_028436101|]
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protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 [Perca flavescens]

Protein Classification

DUF563 and FN3 domain-containing protein( domain architecture ID 10519000)

DUF563 and FN3 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_61 super family cl15705
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
411-523 3.04e-13

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


The actual alignment was detected with superfamily member COG4421:

Pssm-ID: 472831  Cd Length: 258  Bit Score: 70.38  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604835206 411 EDNKEKRDEYIVVfSRSAT--RLIVNEAELImALAQEFQMRVVTvsLEEQSFPGIVQVISGASMLVSMHGAQLITSLFLP 488
Cdd:COG4421   117 ATPPPAPPRRIYI-SRRDAsrRRILNEEELE-ALLEKYGFEIVD--PEELSFAEQIALFAEAEVIVGPHGAGLTNLVFCR 192
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1604835206 489 RGAAVVELFpfavnPEQYTP--YKTLATLPGMDLHYV 523
Cdd:COG4421   193 PGTKVIELF-----PPGYVNpyFWLLAALLGLRYYYL 224
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
634-712 1.59e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604835206 634 LTVSWQIPwnlKYLKVREVKYEVWIQEQGENTYMPY---ILPQQNYTFSeNIKPFTTYLVWVRCIfNKNLLGPFADVLMC 710
Cdd:cd00063    17 VTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLT-GLKPGTEYEFRVRAV-NGGGESPPSESVTV 91

                  ..
gi 1604835206 711 RT 712
Cdd:cd00063    92 TT 93
 
Name Accession Description Interval E-value
COG4421 COG4421
Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
411-523 3.04e-13

Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443536  Cd Length: 258  Bit Score: 70.38  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604835206 411 EDNKEKRDEYIVVfSRSAT--RLIVNEAELImALAQEFQMRVVTvsLEEQSFPGIVQVISGASMLVSMHGAQLITSLFLP 488
Cdd:COG4421   117 ATPPPAPPRRIYI-SRRDAsrRRILNEEELE-ALLEKYGFEIVD--PEELSFAEQIALFAEAEVIVGPHGAGLTNLVFCR 192
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1604835206 489 RGAAVVELFpfavnPEQYTP--YKTLATLPGMDLHYV 523
Cdd:COG4421   193 PGTKVIELF-----PPGYVNpyFWLLAALLGLRYYYL 224
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
421-494 6.79e-11

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


Pssm-ID: 428020  Cd Length: 124  Bit Score: 60.02  E-value: 6.79e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1604835206 421 IVVFSRSAT--RLIVNEAELIMALAQEFQmrVVTVSLEEQSFPGIVQVISGASMLVSMHGAQLITSLFLPRGAAVV 494
Cdd:pfam04577  51 YVYISRGDArrRRILNEDELEAALKKEYG--FEIVDPEKLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVVV 124
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
634-712 1.59e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604835206 634 LTVSWQIPwnlKYLKVREVKYEVWIQEQGENTYMPY---ILPQQNYTFSeNIKPFTTYLVWVRCIfNKNLLGPFADVLMC 710
Cdd:cd00063    17 VTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLT-GLKPGTEYEFRVRAV-NGGGESPPSESVTV 91

                  ..
gi 1604835206 711 RT 712
Cdd:cd00063    92 TT 93
 
Name Accession Description Interval E-value
COG4421 COG4421
Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
411-523 3.04e-13

Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443536  Cd Length: 258  Bit Score: 70.38  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604835206 411 EDNKEKRDEYIVVfSRSAT--RLIVNEAELImALAQEFQMRVVTvsLEEQSFPGIVQVISGASMLVSMHGAQLITSLFLP 488
Cdd:COG4421   117 ATPPPAPPRRIYI-SRRDAsrRRILNEEELE-ALLEKYGFEIVD--PEELSFAEQIALFAEAEVIVGPHGAGLTNLVFCR 192
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1604835206 489 RGAAVVELFpfavnPEQYTP--YKTLATLPGMDLHYV 523
Cdd:COG4421   193 PGTKVIELF-----PPGYVNpyFWLLAALLGLRYYYL 224
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
421-494 6.79e-11

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


Pssm-ID: 428020  Cd Length: 124  Bit Score: 60.02  E-value: 6.79e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1604835206 421 IVVFSRSAT--RLIVNEAELIMALAQEFQmrVVTVSLEEQSFPGIVQVISGASMLVSMHGAQLITSLFLPRGAAVV 494
Cdd:pfam04577  51 YVYISRGDArrRRILNEDELEAALKKEYG--FEIVDPEKLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVVV 124
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
634-712 1.59e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604835206 634 LTVSWQIPwnlKYLKVREVKYEVWIQEQGENTYMPY---ILPQQNYTFSeNIKPFTTYLVWVRCIfNKNLLGPFADVLMC 710
Cdd:cd00063    17 VTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLT-GLKPGTEYEFRVRAV-NGGGESPPSESVTV 91

                  ..
gi 1604835206 711 RT 712
Cdd:cd00063    92 TT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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