NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1570487694|ref|XP_027898882|]
View 

heparan sulfate glucosamine 3-O-sulfotransferase 2-like [Xiphophorus couchianus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
118-355 2.65e-45

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 155.96  E-value: 2.65e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 118 LPNALIVGVKKGGTRAVLEFIRIHPDVRALG--TEPHFFD-RNYDRGLDWYRGLMPRTLDSQI-TLEKTPS--YFVTREA 191
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEksEEPHLFNnHNRSPFLEWYPGDTYFDVAEGPvRLNALPSprIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 192 PHR--ISSMSHDTKLIVVVRNPVTRAISDYTQT----LSKKPDIPTFEELAFknqslglvdtSWNAIRIGMYILHLENWL 265
Cdd:pfam00685  81 LHLlpKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 266 QYFRLSQMHFVSGERLITDPAGEMGRVQDFLGLKR-----IITDKHFYFNRTKGFPCLKKPESSSQ-----PRCLGKSKg 335
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSKLPKEvspffRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1570487694 336 rtHVQIEQEVIEQLQEFYRP 355
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
118-355 2.65e-45

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 155.96  E-value: 2.65e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 118 LPNALIVGVKKGGTRAVLEFIRIHPDVRALG--TEPHFFD-RNYDRGLDWYRGLMPRTLDSQI-TLEKTPS--YFVTREA 191
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEksEEPHLFNnHNRSPFLEWYPGDTYFDVAEGPvRLNALPSprIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 192 PHR--ISSMSHDTKLIVVVRNPVTRAISDYTQT----LSKKPDIPTFEELAFknqslglvdtSWNAIRIGMYILHLENWL 265
Cdd:pfam00685  81 LHLlpKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 266 QYFRLSQMHFVSGERLITDPAGEMGRVQDFLGLKR-----IITDKHFYFNRTKGFPCLKKPESSSQ-----PRCLGKSKg 335
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSKLPKEvspffRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1570487694 336 rtHVQIEQEVIEQLQEFYRP 355
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
118-355 2.65e-45

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 155.96  E-value: 2.65e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 118 LPNALIVGVKKGGTRAVLEFIRIHPDVRALG--TEPHFFD-RNYDRGLDWYRGLMPRTLDSQI-TLEKTPS--YFVTREA 191
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEksEEPHLFNnHNRSPFLEWYPGDTYFDVAEGPvRLNALPSprIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 192 PHR--ISSMSHDTKLIVVVRNPVTRAISDYTQT----LSKKPDIPTFEELAFknqslglvdtSWNAIRIGMYILHLENWL 265
Cdd:pfam00685  81 LHLlpKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 266 QYFRLSQMHFVSGERLITDPAGEMGRVQDFLGLKR-----IITDKHFYFNRTKGFPCLKKPESSSQ-----PRCLGKSKg 335
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSKLPKEvspffRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1570487694 336 rtHVQIEQEVIEQLQEFYRP 355
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
123-298 4.16e-15

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 72.32  E-value: 4.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 123 IVGVKKGGTRAVLEFIRIHPDVRALGTEPHFFDRNYDRGLDW---YRGLMPRTLDSQITLEKTPSYFVTREAPHRIssms 199
Cdd:pfam13469   3 IVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIPRILALLQAWgksLEALARVPSYARWLCDKSPSHLFHLDLLLKA---- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570487694 200 H-DTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEELafknQSLGLVDTSWNAiriGMYILHlENWLQYFRlSQMHFVSG 278
Cdd:pfam13469  79 FpDAKFIHLHRDPVDTVISSYCSLFGFTLSSYSTAFL----RDIGLALARWSR---AYERLM-AARARVPP-GRFLDVRY 149

                         170       180
                  ....*....|....*....|
gi 1570487694 279 ERLITDPAGEMGRVQDFLGL 298
Cdd:pfam13469 150 EDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH