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Conserved domains on  [gi|1488327314|ref|XP_026582457|]
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glycosyltransferase 8 domain-containing protein 2 [Pseudonaja textilis]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 52-337 6.63e-71

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06429:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 257  Bit Score: 221.49  E-value: 6.63e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  52 IPVVLcAAAGRMGATIAAINSIYTNTD-SNVLFYIVGIKSSIPHIRQWIENSIVKDIKFKIVEFNPMVLKGKI------- 123
Cdd:cd06429     1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVkvdslmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 124 --------RPDATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTRGHAAAFSDdcdlpsthemv 195
Cdd:cd06429    80 leseadtsNLKQRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 196 rsvgmqntymgfldyrkqtirdlgispstcTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAEnlySSTLAGGVATSPML 275
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488327314 276 IVFHGRYTSINPLWHVRHLGWSPDARysEHFLQEAKLLHWNGRYKPWGYPSGH--IDFWEKWFV 337
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPsyKELWEKYLS 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 52-337 6.63e-71

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 221.49  E-value: 6.63e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  52 IPVVLcAAAGRMGATIAAINSIYTNTD-SNVLFYIVGIKSSIPHIRQWIENSIVKDIKFKIVEFNPMVLKGKI------- 123
Cdd:cd06429     1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVkvdslmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 124 --------RPDATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTRGHAAAFSDdcdlpsthemv 195
Cdd:cd06429    80 leseadtsNLKQRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 196 rsvgmqntymgfldyrkqtirdlgispstcTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAEnlySSTLAGGVATSPML 275
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488327314 276 IVFHGRYTSINPLWHVRHLGWSPDARysEHFLQEAKLLHWNGRYKPWGYPSGH--IDFWEKWFV 337
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPsyKELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 53-324 1.86e-47

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 160.95  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  53 PVVLCAAAGRMGATIAAINSIYTNT-DSNVLFYIVGIKSSIPHIRQWIENSIVKDIKFKIVEFNPMVLKGKIRPDATRPE 131
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 132 LLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDcdlpsthemvrsvgmqnTYMGFLDYR 211
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 212 KQTIRDLGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYssTLAggvATSPMLIVFHGRYTSINPLWHV 291
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNENRTLW--KLG---DQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1488327314 292 RHLGWSPDARYSEHFLQEAKLLHWNGRYKPWGY 324
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPWLD 250
PLN02659 PLN02659
Probable galacturonosyltransferase
 115-322 4.89e-23

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 100.11  E-value: 4.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 115 NPMVLKGKIRpdATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDCDlpSTHEM 194
Cdd:PLN02659  311 KPHVIAAKLQ--ALSPKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GKVNGAVETCR--GEDKF 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 195 VRSVGMQNtymgFLDYRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYSSTLAggvATSPM 274
Cdd:PLN02659  386 VMSKKLKS----YLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKSDLSLWQLG---TLPPG 457

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1488327314 275 LIVFHGRYTSINPLWHVRHLGWSPDARYSEhfLQEAKLLHWNGRYKPW 322
Cdd:PLN02659  458 LIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPW 503
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 52-328 3.65e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 94.66  E-value: 3.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  52 IPVVLCAAAGRMGATIAAINSIYTNT-DSNVLFYIV--GIKS-SIPHIRQWIENSivkDIKFKIVEFNPMVLKG----KI 123
Cdd:COG1442     6 INIVFAIDDNYLPGLGVSIASLLENNpDRPYDFHILtdGLSDeNKERLEALAAKY---NVSIEFIDVDDELLKDlpvsKH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 124 RPDATrpellqplnFVRFYLP-LLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDCDLpsthemvrsvgmqn 202
Cdd:COG1442    83 ISKAT---------YYRLLIPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTV-------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 203 tyMGFLDYRKQTirdLGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYsstlaggvatsP----MLIVF 278
Cdd:COG1442   139 --TGSQKKRAKR---LGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVL 202

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1488327314 279 HGRYTSINPLW-----HVRHLGWSPDARYSEHFLQEAKLLHWNGRYKPWGYPSGH 328
Cdd:COG1442   203 GGKVKFLPPRYnyqysLYYELKDKSNKKELLEARKNPVIIHYTGPTKPWHKWCTH 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 52-337 6.63e-71

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 221.49  E-value: 6.63e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  52 IPVVLcAAAGRMGATIAAINSIYTNTD-SNVLFYIVGIKSSIPHIRQWIENSIVKDIKFKIVEFNPMVLKGKI------- 123
Cdd:cd06429     1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVkvdslmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 124 --------RPDATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTRGHAAAFSDdcdlpsthemv 195
Cdd:cd06429    80 leseadtsNLKQRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 196 rsvgmqntymgfldyrkqtirdlgispstcTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAEnlySSTLAGGVATSPML 275
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488327314 276 IVFHGRYTSINPLWHVRHLGWSPDARysEHFLQEAKLLHWNGRYKPWGYPSGH--IDFWEKWFV 337
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPsyKELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 53-324 1.86e-47

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 160.95  E-value: 1.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  53 PVVLCAAAGRMGATIAAINSIYTNT-DSNVLFYIVGIKSSIPHIRQWIENSIVKDIKFKIVEFNPMVLKGKIRPDATRPE 131
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 132 LLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDcdlpsthemvrsvgmqnTYMGFLDYR 211
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 212 KQTIRDLGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYssTLAggvATSPMLIVFHGRYTSINPLWHV 291
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNENRTLW--KLG---DQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1488327314 292 RHLGWSPDARYSEHFLQEAKLLHWNGRYKPWGY 324
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPWLD 250
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 54-324 1.68e-34

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 126.79  E-value: 1.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  54 VVLCAAAGRMGATIAAINSIYTNTDSNVLFYIvgIKSSIPH-IRQWIENsiVKDIKFKIVEFNPMVLKGKIRPDaTRPEL 132
Cdd:cd00505     4 VIVATGDEYLRGAIVLMKSVLRHRTKPLRFHV--LTNPLSDtFKAALDN--LRKLYNFNYELIPVDILDSVDSE-HLKRP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 133 LQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTRGHAAAFSDDCDlpsthemvrsvgmqnTYMGFLDYRK 212
Cdd:cd00505    79 IKIVTLTKLHLPNLVPDYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGD---------------RREGKYYRQK 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 213 QTIRDLgispsTCTFNPGVIVANMTEW-KHQRITKQLEKWMQKNVAENLYSSTLAGGVATSPMLIVFHgrytsINPLWHV 291
Cdd:cd00505   144 RSHLAG-----PDYFNSGVFVVNLSKErRNQLLKVALEKWLQSLSSLSGGDQDLLNTFFKQVPFIVKS-----LPCIWNV 213

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1488327314 292 RHLGWSPDARYSEHFLQEAKLLHWNGRYKPWGY 324
Cdd:cd00505   214 RLTGCYRSLNCFKAFVKNAKVIHFNGPTKPWNK 246
PLN02659 PLN02659
Probable galacturonosyltransferase
 115-322 4.89e-23

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 100.11  E-value: 4.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 115 NPMVLKGKIRpdATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDCDlpSTHEM 194
Cdd:PLN02659  311 KPHVIAAKLQ--ALSPKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GKVNGAVETCR--GEDKF 385

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 195 VRSVGMQNtymgFLDYRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYSSTLAggvATSPM 274
Cdd:PLN02659  386 VMSKKLKS----YLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKSDLSLWQLG---TLPPG 457

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1488327314 275 LIVFHGRYTSINPLWHVRHLGWSPDARYSEhfLQEAKLLHWNGRYKPW 322
Cdd:PLN02659  458 LIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPW 503
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 52-328 3.65e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 94.66  E-value: 3.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  52 IPVVLCAAAGRMGATIAAINSIYTNT-DSNVLFYIV--GIKS-SIPHIRQWIENSivkDIKFKIVEFNPMVLKG----KI 123
Cdd:COG1442     6 INIVFAIDDNYLPGLGVSIASLLENNpDRPYDFHILtdGLSDeNKERLEALAAKY---NVSIEFIDVDDELLKDlpvsKH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 124 RPDATrpellqplnFVRFYLP-LLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDCDLpsthemvrsvgmqn 202
Cdd:COG1442    83 ISKAT---------YYRLLIPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTV-------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 203 tyMGFLDYRKQTirdLGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYsstlaggvatsP----MLIVF 278
Cdd:COG1442   139 --TGSQKKRAKR---LGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVL 202

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1488327314 279 HGRYTSINPLW-----HVRHLGWSPDARYSEHFLQEAKLLHWNGRYKPWGYPSGH 328
Cdd:COG1442   203 GGKVKFLPPRYnyqysLYYELKDKSNKKELLEARKNPVIIHYTGPTKPWHKWCTH 257
PLN02742 PLN02742
Probable galacturonosyltransferase
 130-322 1.60e-21

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 95.61  E-value: 1.60e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 130 PELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLtRGHAAAFSDDCdLPSTHEmvrsvgmqntYMGFLD 209
Cdd:PLN02742  333 PKYLSMLNHLRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDL-HGNVNGAVETC-LETFHR----------YHKYLN 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 210 YRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYS-STLaggvatSPMLIVFHGRYTSINPL 288
Cdd:PLN02742  401 FSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVDRTLWKlGTL------PPGLLTFYGLTEPLDRR 473

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1488327314 289 WHVRHLGWSPDArySEHFLQEAKLLHWNGRYKPW 322
Cdd:PLN02742  474 WHVLGLGYDTNI--DPRLIESAAVLHFNGNMKPW 505
PLN02870 PLN02870
Probable galacturonosyltransferase
 113-335 1.26e-20

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 92.69  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 113 EFNPMVLKGKIRpdATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLtRGHAAAFSDDCDlpSTH 192
Cdd:PLN02870  308 ETTPRTFASKLQ--ARSPKYISLLNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDL-GGKVNGAVETCR--GED 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 193 EMVRSVGMQNtYMGFldyrKQTIRDLGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYSSTLAggvATS 272
Cdd:PLN02870  383 EWVMSKRFRN-YFNF----SHPLIAKNLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNLTMWKLG---TLP 454

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1488327314 273 PMLIVFHGRYTSINPLWHVRHLGWSPDARYSEhfLQEAKLLHWNGRYKPW---GYPsgHID-FWEKW 335
Cdd:PLN02870  455 PALIAFKGHVHPIDPSWHMLGLGYQSKTNIES--VKKAAVIHYNGQSKPWleiGFE--HLRpFWTKY 517
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 68-322 1.01e-19

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 86.88  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  68 AAINSIYTNTD-SNVLFYIV--GI-KSSIPHIRQWIE--NSIVKDIKFKIVEFNPMVLKGKIRPDATrpellqplnFVRF 141
Cdd:cd04194    17 VTIKSILANNSkRDYDFYILndDIsEENKKKLKELLKkyNSSIEFIKIDNDDFKFFPATTDHISYAT---------YYRL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 142 YLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDCdlpsthemvrsvgmqntymgFLDYRKQTIRDLGIS 221
Cdd:cd04194    88 LIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP--------------------FIEQEKKRKRRLGGY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 222 PSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYS--STLAggvatspmlIVFHGRYTSINPLW--HVRHLGWS 297
Cdd:cd04194   147 DDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIYPdqDILN---------AVLKDKILYLPPRYnfQTGFYYLL 217

                         250       260
                  ....*....|....*....|....*....
gi 1488327314 298 PDARYSEHFLQEA----KLLHWNGRYKPW 322
Cdd:cd04194   218 KKKSKEEQELEEArknpVIIHYTGSDKPW 246
PLN02867 PLN02867
Probable galacturonosyltransferase
 126-325 6.07e-19

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 87.65  E-value: 6.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 126 DATRPELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTRGHAAAFSD----DCDLPSthemvrsvgmq 201
Cdd:PLN02867  321 EALSPSCLSLLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDLNGKVVGAVVDswcgDNCCPG----------- 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 202 NTYMGFLDYRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLyssTLAGGVATSPMLIVFHGR 281
Cdd:PLN02867  390 RKYKDYLNFSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLKLSLNSGL---QLWQPGALPPALLAFKGH 465

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1488327314 282 YTSINPLWHVRHLGWSPdARYSEHFLQEAKLLHWNGRYKPW---GYP 325
Cdd:PLN02867  466 VHPIDPSWHVAGLGSRP-PEVPREILESAAVLHFSGPAKPWleiGFP 511
PLN02829 PLN02829
Probable galacturonosyltransferase
 130-335 1.34e-18

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 86.83  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 130 PELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLtRGHAAAFSDDCDlPSTHEMVRsvgmqntymgFLD 209
Cdd:PLN02829  437 PKYLSILNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDL-KGNVNGAVETCG-ESFHRFDR----------YLN 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 210 YRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYS-STLaggvatSPMLIVFHGRYTSINPL 288
Cdd:PLN02829  505 FSNPLISK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLNHDRQLWKlGTL------PPGLITFWKRTYPLDRS 577

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1488327314 289 WHVRHLGWSPDARYSEhfLQEAKLLHWNGRYKPW---GYPSgHIDFWEKW 335
Cdd:PLN02829  578 WHVLGLGYNPNVNQRD--IERAAVIHYNGNMKPWleiGIPK-YRNYWSKY 624
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 130-339 5.16e-18

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 85.38  E-value: 5.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 130 PELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLtRGHAAAFSDDCDlPSTHEMVRsvgmqntymgFLD 209
Cdd:PLN02910  455 PKYLSMLNHLRFYLPEVYPKLEKILFLDDDIVVQKDLTPLWSIDM-QGMVNGAVETCK-ESFHRFDK----------YLN 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 210 YRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYS-STLaggvatSPMLIVFHGRYTSINPL 288
Cdd:PLN02910  523 FSNPKISE-NFDPNACGWAFGMNMFDLKEWRKRNITGIYHYWQDLNEDRTLWKlGSL------PPGLITFYNLTYPLDRS 595

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1488327314 289 WHVRHLGWSPDARYSEhfLQEAKLLHWNGRYKPW------GYPSghidFWEKWFVPD 339
Cdd:PLN02910  596 WHVLGLGYDPALNQTE--IENAAVVHYNGNYKPWldlaiaKYKP----YWSRYVQYD 646
PLN02523 PLN02523
galacturonosyltransferase
 130-322 2.44e-17

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 83.00  E-value: 2.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 130 PELLQPLNFVRFYLPLLTHEHEKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDCdLPSTHEmvrsvgmqntYMGFLD 209
Cdd:PLN02523  357 PKYLSMLNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGLWKIDMD-GKVNGAVETC-FGSFHR----------YAQYLN 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 210 YRKQTIRDlGISPSTCTFNPGVIVANMTEWKHQRITKQLEKWMQKNVAENLYSS-TLaggvatSPMLIVFHGRYTSINPL 288
Cdd:PLN02523  425 FSHPLIKE-KFNPKACAWAYGMNIFDLDAWRREKCTEQYHYWQNLNENRTLWKLgTL------PPGLITFYSTTKPLDKS 497

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1488327314 289 WHVRHLGWSPDARYSEhfLQEAKLLHWNGRYKPW 322
Cdd:PLN02523  498 WHVLGLGYNPSISMDE--IRNAAVIHFNGNMKPW 529
PLN02718 PLN02718
Probable galacturonosyltransferase
 81-331 8.77e-15

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 75.31  E-value: 8.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314  81 VLFYIVGIKSSIPHIRQW----------IENSIVKDIKFKIVEFNPMVLKgkirPDATRPELLQPLNFVRFYLPLLTHEH 150
Cdd:PLN02718  343 IVFHVVTDSLNYPAISMWfllnppgkatIQILNIDDMNVLPADYNSLLMK----QNSHDPRYISALNHARFYLPDIFPGL 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 151 EKVIYLDDDVIVQGDIQDLYDMKLTrGHAAAFSDDC--DLPSTHEMvrsvgmqNTYMGFLDyrkqTIRDLGISPSTCTFN 228
Cdd:PLN02718  419 NKIVLFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCleGEPSFRSM-------DTFINFSD----PWVAKKFDPKACTWA 486

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 229 PGVIVANMTEWKHQRITKQLEKWMQKNVAENLYSS-TLAGGVATspmlivFHGRYTSINPLWHVRHLGWSPDARYSEhfL 307
Cdd:PLN02718  487 FGMNLFDLEEWRRQKLTSVYHKYLQLGVKRPLWKAgSLPIGWLT------FYNQTVALDKRWHVLGLGHESGVGASD--I 558

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1488327314 308 QEAKLLHWNGRYKPW---------GYPSGHIDF 331
Cdd:PLN02718  559 EQAAVIHYDGVMKPWldigigkykRYWNIHVPY 591
PLN02769 PLN02769
Probable galacturonosyltransferase
 142-322 6.86e-09

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 57.01  E-value: 6.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 142 YLPLLTHEH----------EKVIYLDDDVIVQGDIQDLY--DMKLTRGHAAAFsddCDLpsthemvrSVGMQNTYMGfld 209
Cdd:PLN02769  434 YLSVFSHSHfllpeifkklKKVVVLDDDVVVQRDLSFLWnlDMGGKVNGAVQF---CGV--------RLGQLKNYLG--- 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 210 yrkqtirDLGISPSTCTFNPGVIVANMTEWKHQRITK---QLEKWMQKNVAENLysstlaGGVATSPMLIVFHGRYTSIN 286
Cdd:PLN02769  500 -------DTNFDTNSCAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESL------RAAALPASLLTFQDLIYPLD 566

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1488327314 287 PLWHVRHLGWspDARYSEHFLQEAKLLHWNGRYKPW 322
Cdd:PLN02769  567 DRWVLSGLGH--DYGIDEQAIKKAAVLHYNGNMKPW 600
PRK15171 PRK15171
lipopolysaccharide 3-alpha-galactosyltransferase;
148-247 3.64e-05

lipopolysaccharide 3-alpha-galactosyltransferase;


Pssm-ID: 185093 [Multi-domain]  Cd Length: 334  Bit Score: 45.13  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488327314 148 HEHEKVIYLDDDVIVQGDIQDLYDMKLTRGHAAAFSDDCDLpsthemvrsvgmqntymGFLDYRKQTIRDLGISPStcTF 227
Cdd:PRK15171  119 DKTDKVLYLDADIACKGSIKELIDLDFAENEIAAVVAEGDA-----------------EWWSKRAQSLQTPGLASG--YF 179

                          90       100
                  ....*....|....*....|
gi 1488327314 228 NPGVIVANMTEWKHQRITKQ 247
Cdd:PRK15171  180 NSGFLLINIPAWAQENISAK 199
GT8_HUGT1_C_like cd06432
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ...
 151-194 2.52e-03

The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.


Pssm-ID: 133054  Cd Length: 248  Bit Score: 38.91  E-value: 2.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1488327314 151 EKVIYLDDDVIVQGDIQDLYDMKLtRGHAAAFSDDCDlpSTHEM 194
Cdd:cd06432    97 DKVIFVDADQIVRTDLKELMDMDL-KGAPYGYTPFCD--SRKEM 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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