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Conserved domains on  [gi|1484478098|ref|XP_026468030|]
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diamine acetyltransferase 2-like [Ctenocephalides felis]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
25-89 1.47e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 51.24  E-value: 1.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098  25 CAVAEDEHQyLVGYVIYFPIYIPRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRI 89
Cdd:COG3153    41 SLVAEDDGE-IVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAV 104
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
25-89 1.47e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 51.24  E-value: 1.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098  25 CAVAEDEHQyLVGYVIYFPIYIPRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRI 89
Cdd:COG3153    41 SLVAEDDGE-IVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAV 104
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 25-89 5.02e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.04  E-value: 5.02e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098 25 CAVAEDEHQyLVGYVIYFPIyiPRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRI 89
Cdd:cd04301    1 FLVAEDDGE-IVGFASLSPD--GSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-93 9.09e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 45.97  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484478098  12 LEKDGFGENPLFQCAVAEDEHqyLVGYVIYFPIYipRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRIDW 91
Cdd:pfam00583  23 LLEDWDEDASEGFFVAEEDGE--LVGFASLSIID--DEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFL 98


                  ..
gi 1484478098  92 RV 93
Cdd:pfam00583  99 EV 100
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
25-89 1.47e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 51.24  E-value: 1.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098  25 CAVAEDEHQyLVGYVIYFPIYIPRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRI 89
Cdd:COG3153    41 SLVAEDDGE-IVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAV 104
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 25-89 5.02e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.04  E-value: 5.02e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098 25 CAVAEDEHQyLVGYVIYFPIyiPRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRI 89
Cdd:cd04301    1 FLVAEDDGE-IVGFASLSPD--GSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
20-94 2.58e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 48.45  E-value: 2.58e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1484478098  20 NPLFQCAVAEDEHQyLVGYVIYFPiYIPRLG-KSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRIDWRVL 94
Cdd:COG1247    49 APGRPVLVAEEDGE-VVGFASLGP-FRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVL 122
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 37-94 8.99e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 45.42  E-value: 8.99e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1484478098 37 GYVIYFPIYIPRLGksmYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRIDWRVL 94
Cdd:COG0456    1 GFALLGLVDGGDEA---EIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVR 55
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-93 9.09e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 45.97  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484478098  12 LEKDGFGENPLFQCAVAEDEHqyLVGYVIYFPIYipRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRIDW 91
Cdd:pfam00583  23 LLEDWDEDASEGFFVAEEDGE--LVGFASLSIID--DEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFL 98


                  ..
gi 1484478098  92 RV 93
Cdd:pfam00583  99 EV 100
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 21-95 3.01e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 41.29  E-value: 3.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098 21 PLFQCAVAEDEHQyLVGYVIYFPIYiprLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRIDWRVLN 95
Cdd:pfam13508  1 PGGRFFVAEDDGK-IVGFAALLPLD---DEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTN 71
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 18-95 1.75e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 40.42  E-value: 1.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1484478098  18 GENPLFQCAVAEDEHQyLVGYVIYFPIYiprlGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSALDSDCLRIDWRVLN 95
Cdd:COG0454    29 GSLAGAEFIAVDDKGE-PIGFAGLRRLD----DKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLD 101
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 12-81 9.49e-05

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 38.43  E-value: 9.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484478098  12 LEKDGFGENPLFQCAVAEDEHQyLVGYVIYFPIYiprlGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSA 81
Cdd:COG1246    17 LIRPYALEEEIGEFWVAEEDGE-IVGCAALHPLD----EDLAELRSLAVHPDYRGRGIGRRLLEALLAEA 81
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 18-82 6.16e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.09  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1484478098  18 GENPLFqcaVAEDEHQyLVGYViyfpiyipRLGKSMYLQDLYVREQFRKLGIGRRLFTKVAQSAL 82
Cdd:pfam13673  29 GEYFFF---VAFEGGQ-IVGVI--------ALRDRGHISLLFVDPDYQGQGIGKALLEAVEDYAE 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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