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Conserved domains on  [gi|1444531830|ref|XP_025942674|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [Apteryx rowi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 102-327 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467703  Cd Length: 226  Bit Score: 502.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEYFFRETNNTAYVIWG 181
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHIYG 261
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1444531830 262 MINDTYCKSEGFRKVPYHYYEPGRDECEEYFLHENAPYGGHRFITEKKVFAKWAKKHTIIFTHPNW 327
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 102-327 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 502.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEYFFRETNNTAYVIWG 181
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHIYG 261
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1444531830 262 MINDTYCKSEGFRKVPYHYYEPGRDECEEYFLHENAPYGGHRFITEKKVFAKWAKKHTIIFTHPNW 327
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-317 2.82e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 99.22  E-value: 2.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPL-LLKNPEYFFRETNNTAYV-- 178
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDsKYGNLGFSHPRDPFVEFVlv 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 179 -------IWGP--FRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDrvqsGSYLSTGWFTLIL 249
Cdd:pfam00777 123 pfkgrdlLWLPafLTKGNVSRSLRVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLK----GRRPSTGLLMLSL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1444531830 250 AMDACYGIHIYGMINDtycksEGFRKVPYHYYEPGRDeceeyflHENAPYGGHRFITEKKVFAKWAKK 317
Cdd:pfam00777 199 ALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLLQKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 102-327 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 502.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEYFFRETNNTAYVIWG 181
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHIYG 261
Cdd:cd23975    81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1444531830 262 MINDTYCKSEGFRKVPYHYYEPGRDECEEYFLHENAPYGGHRFITEKKVFAKWAKKHTIIFTHPNW 327
Cdd:cd23975   161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 102-325 1.85e-128

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 365.80  E-value: 1.85e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPE-YFFRETNNTAYVIW 180
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAIlLLAGTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 181 GPFRNMRKDGNGIvYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHIY 260
Cdd:cd23965    81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1444531830 261 GMINDTYCKSEGFRKVPYHYYEPGR-DECEEYFLHENAPYGGHRFITEKKVFAKWAKKHTIIFTHP 325
Cdd:cd23965   160 GMVPENYCREHPNSKVPYHYYEPGGlKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 102-328 1.74e-119

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 343.38  E-value: 1.74e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEYFFRETNNTAYVIWG 181
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHIYG 261
Cdd:cd23977    81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1444531830 262 MINDTYCKSEGFRKVPYHYYEPGR-DECEEYFLHENAPYGGHRFITEKKVFAKWAKKHTIIFTHPNWT 328
Cdd:cd23977   161 MVSDSYCRNKNHSSVPYHYYEKGRlDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 102-327 7.13e-91

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 270.96  E-value: 7.13e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEYFFRETNNTAYVIWG 181
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHIYG 261
Cdd:cd23978    81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1444531830 262 MINDTYC-KSEGFRKVPYHYYEP-GRDECEEYFLHENAPYGG-HRFITEKKVFAKWAKKHTIIFTHPNW 327
Cdd:cd23978   161 MVPPNYCsKRPTPKKMPYHYYEPkGPDECVTYIQNEHGRRGNhHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 88-327 5.25e-90

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 269.04  E-value: 5.25e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830  88 GYINVKTQEPLQLDCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEY 167
Cdd:cd23976     1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 168 FFRETNNTAYVIWGPFRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTL 247
Cdd:cd23976    81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 248 ILAMDACYGIHIYGMINDTYCKSEGFRKVPYHYYEP-GRDECEEYFLHENAPYGG-HRFITEKKVFAKWAKKHTIIFTHP 325
Cdd:cd23976   161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPsGPDECTMYISHERGRKGShHRFITEKRVFANWARTFNIHFYQP 240


                  ..
gi 1444531830 326 NW 327
Cdd:cd23976   241 DW 242
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 105-314 5.68e-51

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 167.54  E-value: 5.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLLLKNPEYFF---RETNNTAYVIWG 181
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGChplPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRNMRKDgngivynmLKKTVDSYPAAKIYVTTE--KRMGYCDAVFKKETGKDrVQSGSYLSTGWFTLILAMDACYGIHI 259
Cdd:cd19952    81 AAAADFKR--------LKRRKKRHDNAVLLLTDPapDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1444531830 260 YGMINDTYCKsegfRKVPYHYYEPGRDECEeyflhenapYGGHRFITEKKVFAKW 314
Cdd:cd19952   152 YGFGVDSGHA----PKVPYHYYDLVEAEEG---------TAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-317 2.82e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 99.22  E-value: 2.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPL-LLKNPEYFFRETNNTAYV-- 178
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDsKYGNLGFSHPRDPFVEFVlv 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 179 -------IWGP--FRNMRKDGNGIVYNMLKKTVDSYPAAKIYVTTEKRMGYCDAVFKKETGKDrvqsGSYLSTGWFTLIL 249
Cdd:pfam00777 123 pfkgrdlLWLPafLTKGNVSRSLRVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLK----GRRPSTGLLMLSL 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1444531830 250 AMDACYGIHIYGMINDtycksEGFRKVPYHYYEPGRDeceeyflHENAPYGGHRFITEKKVFAKWAKK 317
Cdd:pfam00777 199 ALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLLQKLHKE 254
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 105-283 4.81e-19

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 85.01  E-value: 4.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTsvpLLLKNPEYFFRET--NNTAYVIWGP 182
Cdd:cd23968    48 CAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ---ILSKPEFNFLTDPlyRNVTLLVWDP 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 183 FRNmrkdgNGIVYNMLKKT-VDSYPAAKIY--VTTEKRMGYCDAVFKKETgKDRVQSGSYL-------STGWFTLILAMD 252
Cdd:cd23968   125 SSY-----NVNLEKWYKKPdFDFFPNYIKYrrRHPEEPFYLIDPRFLWRL-WDILQEYTPEkikpnppSSGFIGIVLMLH 198

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1444531830 253 ACYGIHIYGMI----NDTYCksegfrkvpyHYYEP 283
Cdd:cd23968   199 LCDWVDVYEYVpsvrQTDRC----------HYYDV 223
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 102-318 9.40e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 85.19  E-value: 9.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVS-HTSVPLLLKNPEYFFRET---NNTAY 177
Cdd:cd23973    83 CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTaHSITSSLMILQKRGFKNIpqdKDIKY 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 178 VIwgpFRNMRKDGNGIVYNMLKKTV---------------DSYPAAKIYVTTEKRMGYCdavfkketgKDRVQSGSYL-- 240
Cdd:cd23973   163 IL---FPEGPRDYQWLEALLKNKTIpsgayygrrprsyfsGDFTEDKYLVLHPDFLRYV---------KNRFLRSKTLkg 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 241 --------STGWFTLILAMDACYGIHIYGMIndtyckSEGFRKVPYHYYEpgRDECEEYFlhenapYGGHRFITEKKVfa 312
Cdd:cd23973   231 kywaiyrpTTGAFLLLTALHLCDTVSAYGFI------TEDYRKYPDHYYD--KKKTKLVF------YINHDFRLEKKL-- 294


                  ....*.
gi 1444531830 313 kWAKKH 318
Cdd:cd23973   295 -WKRLH 299
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 105-263 7.17e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 76.41  E-value: 7.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTsvplLLKNPEYFFreTNNTAY-----VI 179
Cdd:cd23986    52 CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHF--IDSSLYkdvilVA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 180 WGP---FRNMRKDGNGIVYNMLKKTVD---SYPAAKIYVTTEKRMGYCDAVFKKETgKDRVQSGSyLSTGWFTLILAMDA 253
Cdd:cd23986   126 WDPapySANLHKWYKKPDYNLFTPYVQyrkRNPNQPFYILHPKFIWQLWDIIQENT-QEKIQPNP-PSSGFIGILIMMSM 203

                         170
                  ....*....|
gi 1444531830 254 CYGIHIYGMI 263
Cdd:cd23986   204 CREVHVYEYI 213
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 102-285 1.68e-15

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 75.39  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVV---------SHTS---VPLLLKNPEYfF 169
Cdd:cd23966    77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMypesavdldPGVHlvlVPFKVLDLQW-L 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 170 RETNNTAYVIWGPFRnMRKdgngivynmlkktvdsypaaKIYVTTEKRMGYCDAVFK--KETGKDRvqSGSYLSTGWFTL 247
Cdd:cd23966   156 ISALTTGEITRTYTP-VKR--------------------FIKADKDKVLVINPAFIKyvHDNWTEH--HGRYPSTGFLAL 212

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1444531830 248 ILAMDACYGIHIYGMINDTYckseGFRkvpYHYYEPGR 285
Cdd:cd23966   213 IFALHICDEVSVFGFGADSK----GNW---HHYWEKNR 243
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 95-282 5.63e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 73.76  E-value: 5.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830  95 QEPLQLDCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSvplllknpeyfFRETNN 174
Cdd:cd23980    74 LEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPES-----------FRELAQ 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 175 TAYVIWGPFRNMrkDGNGIVYNMLKKTVD-SY-PA-AKIYVTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLILAM 251
Cdd:cd23980   143 NVSMILVPFKTL--DLEWVISATTTGTIShTYvPVpRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSL 220

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1444531830 252 DACYGIHIYGMINDtyckSEGFRkvpYHYYE 282
Cdd:cd23980   221 HVCDEVDLYGFGAD----SKGNW---HHYWE 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 105-284 7.23e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 73.45  E-value: 7.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTtvrvvSHTSV-PLLLKNPEYFFRETNNTA------- 176
Cdd:cd23963    66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKT-----NLTTLnPSILKRRYNSLKKNRDRDkflnrlk 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 177 ----YVIWGPfrnmrKDGNGIVYNMLKKTVDSYPAAKIYVTtekrMGYCDAV-------FKKETGKDRvqsgsYLSTGWF 245
Cdd:cd23963   141 eyngSILWYP-----KFSFKSSTNLLLKAARALKKNGLNLT----VVYSNPEhflavqkFWKRRGLEK-----RPSTGLY 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1444531830 246 TLILAMDACYGIHIYG----MINdtyckSEGfRKVPYHYYEPG 284
Cdd:cd23963   207 LVSLALTFCDEIHLYGfwpfPTD-----PNG-RPVPYHYYDDL 243
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 101-283 7.63e-15

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 71.94  E-value: 7.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 101 DCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPLllkNPEyffrETNNTAYVIW 180
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFR---DPE----EYDSDWLLVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 181 GPFRNM----------RKDGNGIVYnMLKKTVDS--YPAAKI-----YVTTEKRMgycDAVFKKETGKdrvQSGSYLSTG 243
Cdd:cd23967    74 VPFKSMdllwlqavikGKKPNGKGG-FWKKIATSvpKPPKKIrilnpYILQEAAF---DLIGLPMNGK---QGKNVPTTG 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1444531830 244 WFTLILAMDACYGIHIYGMINDTYCKsegfrKVPYHYYEP 283
Cdd:cd23967   147 IIAIVMALHYCDEVDIAGFGYDPSDP-----NAPLHYYDS 181
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 101-318 2.17e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 72.29  E-value: 2.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 101 DCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRV-------VSHTSVPLLLKNPEYFF--RE 171
Cdd:cd23964    81 RCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTffpeslhNSLLKHVPQDKDTKYLFipFK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 172 TNNTAYVI----WGPFRNMrKDGNGIVYNMLKKTVdsyPAAKIYVTTEKRMGYCDAVFKketgkdRVQSGSYLSTGWFTL 247
Cdd:cd23964   161 IRDYDYLDavlsGKPVPDG-CDKGKRPPPLFGPKL---NATNVRLLHPDFIRYLFNRWL------NSSTSYRPTTGALML 230

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1444531830 248 ILAMDACYGIHIYGMINDtycksegfRKVPYHYYEPGRdeceeyflHENAP-YGGHRFITEKKVfakWAKKH 318
Cdd:cd23964   231 LTALHTCDQVSVYGFGYD--------PRFSLHYYDKTF--------VKFTVfYANHDFTNERKL---WRKLH 283
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 101-282 9.40e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 68.92  E-value: 9.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 101 DCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVpllLKNPEYffrETNNTAYVIW 180
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESA---QFDPGI---ENDPDTLLVL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 181 GPFRNMrkDGNGIvYNML--KKTVD-----------SYPAAKIYVTTEKRMGycDAVFKKETGKDRVQSGSYLSTGWFTL 247
Cdd:cd23982    75 VPFKPL--DFYWL-YEILsnEKRVRkgfwkqppriwDANPKQIRILNPYYTY--VAATKLLQVPGQRKKKQKPTTGLLAI 149

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1444531830 248 ILAMDACYGIHIYGMindTYCKSeGFRKVPYHYYE 282
Cdd:cd23982   150 TLALHLCDEVHIAGF---GYPDN-GNSNQPIHYYN 180
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 93-285 3.37e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 68.74  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830  93 KTQEPLQldCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTvrvvSHTSVPLLLKNpeyffrET 172
Cdd:cd23979    73 RSWDPSR--CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT----HHFMYPESAKN------LP 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 173 NNTAYVIWgPFRNMrkDGNGIVYNMLKKTVD-SYPAAKIY--VTTEKRMGYCDAVFKKETGKDRVQSGSYLSTGWFTLIL 249
Cdd:cd23979   141 ANVSFVLV-PFKTL--DLLWITSALSTGQIRfTYAPVKQFlrVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFF 217

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1444531830 250 AMDACYGIHIYGMINDTycksegfRKVPYHYYEPGR 285
Cdd:cd23979   218 ALHVCDEVNVYGFGADS-------RGNWHHYWENNR 246
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 105-182 2.62e-12

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 65.88  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTsvplLLKNPEYFFRET---NNTAYVIWG 181
Cdd:cd23985    48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKFLKDslyNEGILIVWD 123


                  .
gi 1444531830 182 P 182
Cdd:cd23985   124 P 124
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 94-285 4.41e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 65.49  E-value: 4.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830  94 TQEPLQLDC-DLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRvvshTSVPLLL-KNPEYFFRE 171
Cdd:cd23970    59 EVSPFQNKHyNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSILeKYYNNLLTI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 172 TNNTAYviwgpFRNMRKDGNGIvynmLKKTVDSYPAAKIYVTT------EKR-------------MGYCDAVFKKETGKD 232
Cdd:cd23970   135 QDRNNF-----FLSLKKLDGAI----LWIPAFFFHTSATVTRTlvdffvEHRgqlkvqlawpgniMQHVNRYWKTKHLSP 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1444531830 233 RvqsgsYLSTGWFTLILAMDACYGIHIYGMIndTYCKSEGFRKVPYHYYEPGR 285
Cdd:cd23970   206 K-----RLSTGILMYTLASAICEEIHLYGFW--PFGFDPTGTPLPYHYYDKKG 251
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 102-282 3.61e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 61.69  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVpllLKNPEYFfrETNNTayVIWG 181
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI---FSDPSHY--DPNTT--VVLI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 182 PFRnmRKDGNGIVYNMLKKTVDSY-----PAAK-IYVTTEKRMgyCDAVFKKETGKD---------RVQSGSYLSTGWFT 246
Cdd:cd23984    75 PFK--PHDLRWLLDLLMGKKVSAKgfwkkPALNlIYKPNQIRI--LNPFILRIAAYEllhfpkrfpKEKKPKHPTTGIIA 150

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1444531830 247 LILAMDACYGIHIYGMindTYCKSEgfRKVPYHYYE 282
Cdd:cd23984   151 ITLALHICNEVHIAGF---KYDFSN--LNSTLHYYG 181
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 102-152 1.55e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 59.94  E-value: 1.55e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRV 152
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 101-160 2.65e-10

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 59.37  E-value: 2.65e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 101 DCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVSHTSVPL 160
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPK 60
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 102-154 3.03e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 57.46  E-value: 3.03e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVRVVS 154
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFS 136
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 105-285 4.51e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 56.65  E-value: 4.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTVrVVSHTSVPlllknPEYFFRETNNTAY------- 177
Cdd:cd23969    67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-TTMNPSVI-----PHAYGDLVNATDKekfverl 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 178 ------VIWGP-FrnMRKDGNG--------IVYNMLK-KTVdsYPAA-------KIYVTTEKRMgycdavfkketgkDRV 234
Cdd:cd23969   141 rqlgdsILWIPaF--VSKGGEEhvqwtneiILKHKLNvKTA--YPPLrlnhairGYWLTTKFRI-------------KRP 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1444531830 235 QSGSYLSTgwftliLAMDACYGIHIYGMI---NDTYCksegfRKVPYHYYEPGR 285
Cdd:cd23969   204 STGLLMYT------LATRFCDEIHLYGFYpfsEDGNG-----RAVKYHYYDNRK 246
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 102-295 1.94e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 54.83  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 102 CDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRT-----TVRVVSHTsvplLLKNPEYFFRET---N 173
Cdd:cd23972    82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNS----LISYWNLGFTRTpqgQ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 174 NTAYV-IWGPFRNmrkdgngivYNMLKKTVDSYPAAKIYVTTEKRMGY--CDAVFKK---------ETGKDRVQSGSYL- 240
Cdd:cd23972   158 DLQYIfIPSDIRD---------YVMLRSAILGVPVPEGLDKGDRPHKYfgPEASAKKfkllhpdfiSYLTDRFLKSKLLn 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1444531830 241 ---------STGWFTLILAMDACYGIHIYGMINDTYcksegfRKVPYHYYEPGRDECEEYFLHE 295
Cdd:cd23972   229 thyghlympSTGALMLLTALHTCDQVSAYGFITSNY------WKFSDHYYERKKKPLVFYANHD 286
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 105-319 1.62e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 51.88  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTvrvvshtsvpLLLKNPEYFFRetnntayvIWGPFR 184
Cdd:cd23988    67 CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSD----------FITMNPSVVQR--------AFGGFR 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 185 NmRKDGNGIVY--NMLKKTVDSYPAAKIYvTTEKRMGYCDAVFKKETGKDRVQ----------SGSYL---------STG 243
Cdd:cd23988   129 N-ESDREKFVHrlSMLNDSVLWIPAFMVK-GGEKHVEWVNALILKNKLKVRTAypslrlihavRGYWLtnkvnikrpSTG 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 244 WFTLILAMDACYGIHIYGMIndTYCKSEGFRKVPYHYYepgrDECE-EYFlhENApyGGHR----FITEKKVFAKWAKKH 318
Cdd:cd23988   207 LLMYTLATRFCDEIHLYGFW--PFPKDANGNPVKYHYY----DDLKyRYF--SNA--GPHRmpleFKTLNVLHNRGALKL 276


                  .
gi 1444531830 319 T 319
Cdd:cd23988   277 T 277
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 97-282 7.56e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 49.83  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830  97 PLQLDCDLCAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAP-TKGYEEDVGKRTTvrvvshtsvpLLLKNPEyffretnnt 175
Cdd:cd23989    58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQ----------LVTANPS--------- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 176 ayVIWGPFRNMRKDGNGIVYNMlKKTVDSY-------------PAAKIYVT-----TEKRMGYCDAVFKKETG---KDRV 234
Cdd:cd23989   119 --IIDKRFQNLLWSRKSFVESM-KVYGRSYiympafsmktgtdPSLRVYYTladvgANQTVLFANPNFLRNVGkfwKSKG 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1444531830 235 QSGSYLSTGWFTLILAMDACYGIHIYGMIndTYCKSEGFRKVPYHYYE 282
Cdd:cd23989   196 VHAKRLSTGLFLVSAALGLCEEVTIYGFW--PFSVDLDERTISHHYYD 241
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 105-282 8.23e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 49.55  E-value: 8.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKGYEEDVGKRTTvrvvshtsvpLLLKNPEYF---FRETNNTAY---- 177
Cdd:cd23987    67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTD----------LVTMNPSVVqraFEDLVNETWkekf 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 178 ----------VIWGPfRNMRKDGNGIVY----NMLKKTVD---SYPAAKIYVTTEkrmGYCdavfkkETGKDRVQSGsyl 240
Cdd:cd23987   137 lqrlqslngsILWIP-AFMAKGGEERVEwvndLILKHHINvrtAYPSLRLLHAVR---GYW------LTNKVHIKRP--- 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1444531830 241 STGWFTLILAMDACYGIHIYGMIndTYCKSEGFRKVPYHYYE 282
Cdd:cd23987   204 TTGLLMYTLATRFCNRIHLYGFW--PFPRDQNQNPVKYHYYD 243
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 105-282 5.61e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 43.97  E-value: 5.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKG-YEEDVGKRTTvrvvshtsvpLLLKNPEYFFRETNNTAYViWGPF 183
Cdd:cd23991    67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTN----------LVTANPSIISIKYAKLNER-RKPF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 184 RNmrkdgNGIVYN--MLKKTVDSYPAA-----KIYVTTEKRMGYCDAVFKKET--------GKDRVQSGSYLSTGWFTLI 248
Cdd:cd23991   136 LE-----TVSVYGdaFLLLPAFSYRSNtalsfKVYYTLEDFKAKQKVIFFHPIylkhlaqfWRSKGVQVYRLSTGLMITS 210

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1444531830 249 LAMDACYGIHIYGMIndTYCKSEGFRKVPYHYYE 282
Cdd:cd23991   211 AALELCEEVKLYGFW--PFSKNTEGKPISHHYYD 242
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 105-148 4.56e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 41.09  E-value: 4.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAPTKgYEEDVGKRT 148
Cdd:cd23971    67 CAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT 109
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 105-282 2.37e-03

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 39.05  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 105 CAIVSNSGQMAGQKVGAEIDKSSCIWRMNNAP-TKGYEEDVGKRTTVRVVSHTSVPLLL------KNPEYFFRETNNTAY 177
Cdd:cd23990    67 CAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITERFhklekwRRPFYEVLQVYENAS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1444531830 178 VIWGPFRNMRkdgNGIVYNMLKKTVDSYPAAKI-------YVTTEKRMGYCDAVFKKetgkdRVQSGSYLSTGwftlilA 250
Cdd:cd23990   147 VVLPAFYNTR---NTDVSIRVKYVLDDFESQQAvyyfhpqYLLNVSRFWLRQGVRAK-----RISSGLMLVTA------A 212

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1444531830 251 MDACYGIHIYGMINDTYCKSEGFrkVPYHYYE 282
Cdd:cd23990   213 LELCEEVHLYGFWAFPMNPSGIF--ITHHYYD 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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