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Conserved domains on  [gi|1435040549|ref|XP_025787354|]
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serine palmitoyltransferase 1 [Puma concolor]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 1-472 1.03e-167

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02822:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 481  Bit Score: 481.16  E-value: 1.03e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822    8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  70 VPPVSGD--HPALNYNVVSGPpshNIVVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLD 147
Cdd:PLN02822   82 IPPITEEmrPEPPVLESAAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 148 LEDRLAKFMQTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEIE 227
Cdd:PLN02822  159 CETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 228 DqknpRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISANM 307
Cdd:PLN02822  239 N----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAM 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 308 ENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGISGLKVVG 387
Cdd:PLN02822  315 GHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGS 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 388 ESFSPAFHLQLQESTGSREEDVKLLQEIVNHCMDRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTDEELERAARTI 464
Cdd:PLN02822  395 NTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESL 471


                  ....*...
gi 1435040549 465 KEVAQAVL 472
Cdd:PLN02822  472 KRVAASVL 479
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 1-472 1.03e-167

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 481.16  E-value: 1.03e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822    8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  70 VPPVSGD--HPALNYNVVSGPpshNIVVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLD 147
Cdd:PLN02822   82 IPPITEEmrPEPPVLESAAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 148 LEDRLAKFMQTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEIE 227
Cdd:PLN02822  159 CETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 228 DqknpRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISANM 307
Cdd:PLN02822  239 N----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAM 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 308 ENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGISGLKVVG 387
Cdd:PLN02822  315 GHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGS 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 388 ESFSPAFHLQLQESTGSREEDVKLLQEIVNHCMDRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTDEELERAARTI 464
Cdd:PLN02822  395 NTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESL 471


                  ....*...
gi 1435040549 465 KEVAQAVL 472
Cdd:PLN02822  472 KRVAASVL 479
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 2.43e-80

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 254.21  E-value: 2.43e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  84 VVSGPPSHNIVVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAII 163
Cdd:COG0156    23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 164 YSYGFATIASAIPAYSKRGDIVFVDRA--ACfaIQKGLQASRSDIQLFKHNDMADLERLLKEqeiedqknPRKARvtRRF 241
Cdd:COG0156   103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 242 IVVEGLY-MnTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGFCCG 320
Cdd:COG0156   171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGLE-DRVDIIMGTLSKALGSSGGFVAG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 321 RSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIsGLKvVGESFSPAFHLQLqe 400
Cdd:COG0156   249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIV-- 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1435040549 401 stgsreEDVKLLQEIVNHCMDRSIALTQARYlekeekclppPS-------IRVVVTVEQTDEELERAARTIKEVAQA 470
Cdd:COG0156   325 ------GDAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 2.18e-76

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 242.85  E-value: 2.18e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  98 KKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454     1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 178 YSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEqeiedqkNPRKARvtRRFIVVEGLYMNTGTICPL 257
Cdd:cd06454    81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHFGISIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454   152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 338 SASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIsGLKVVGESFSPAFHLQLqestgsreEDVKLLQEIVN 417
Cdd:cd06454   231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIG--------DDPAKAVAFSD 301

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1435040549 418 HCMDRSIALTQARY---LEKEEKclpppsIRVVVTVEQTDEELERAARTIKEV 467
Cdd:cd06454   302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 3.04e-24

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 103.54  E-value: 3.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  98 KKCVNFASFNFLGLLDdPRVKAAALvslrkyGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEE--------AIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDTL-PAVAKAEK------DALAGGTRNLYGPTDGHPELREALAKFLGRSPvlkldreaAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 170 TIASAIPAYSK-RGDIVFVDRAACFAIQKGLQASRSDIQLFK-------HNDMADLERLLKEQeiedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 242 IVVEGLYMNTGTICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsiDDIDLISAN-MENSLASIG-- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLA--EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 316 -GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIsGLKVVGeSFSPAF 394
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 395 HLQLqestGSREEDVKLLQEIVNHCmdrSIALTQARYLEKeekclpPPSIRVVVTVeQTDEELERAARTI 464
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 1-472 1.03e-167

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 481.16  E-value: 1.03e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822    8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  70 VPPVSGD--HPALNYNVVSGPpshNIVVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLD 147
Cdd:PLN02822   82 IPPITEEmrPEPPVLESAAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 148 LEDRLAKFMQTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEIE 227
Cdd:PLN02822  159 CETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 228 DqknpRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISANM 307
Cdd:PLN02822  239 N----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAM 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 308 ENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGISGLKVVG 387
Cdd:PLN02822  315 GHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGS 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 388 ESFSPAFHLQLQESTGSREEDVKLLQEIVNHCMDRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTDEELERAARTI 464
Cdd:PLN02822  395 NTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESL 471


                  ....*...
gi 1435040549 465 KEVAQAVL 472
Cdd:PLN02822  472 KRVAASVL 479
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 101-472 1.63e-113

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 339.96  E-value: 1.63e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 101 VNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIASAIPAYSK 180
Cdd:PLN03227    1 LNFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 181 RGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPEL 260
Cdd:PLN03227   81 RGDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQVRAQDVALKRKPTDQRRFLVVEGLYKNTGTLAPLKEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 261 VKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIS-IDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSA 339
Cdd:PLN03227  161 VALKEEFHYRLILDESFSFGTLGKSGRGSLEHAGLKpMVHAEIVTFSLENAFGSVGGMTVGSEEVVDHQRLSGSGYCFSA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 340 SLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIS---------GLKVVGESFSPAFHLQLQESTGSREED-V 409
Cdd:PLN03227  241 SAPPFLAKADATATAGELAGPQLLNRLHDSIANLYSTLTNSShpyalklrnRLVITSDPISPIIYLRLSDQEATRRTDeT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435040549 410 KLLQEIVNHCMDRSIALTQAR-YLEKEEKCLPPPSIRVVVTVEQTDEELERAARTIKEVAQAVL 472
Cdd:PLN03227  321 LILDQIAHHSLSEGVAVVSTGgHVKKFLQLVPPPCLRVVANASHTREDIDKLLTVLGEAVEAIL 384
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 2.43e-80

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 254.21  E-value: 2.43e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  84 VVSGPPSHNIVVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAII 163
Cdd:COG0156    23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 164 YSYGFATIASAIPAYSKRGDIVFVDRA--ACfaIQKGLQASRSDIQLFKHNDMADLERLLKEqeiedqknPRKARvtRRF 241
Cdd:COG0156   103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 242 IVVEGLY-MnTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGFCCG 320
Cdd:COG0156   171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGLE-DRVDIIMGTLSKALGSSGGFVAG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 321 RSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIsGLKvVGESFSPAFHLQLqe 400
Cdd:COG0156   249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIV-- 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1435040549 401 stgsreEDVKLLQEIVNHCMDRSIALTQARYlekeekclppPS-------IRVVVTVEQTDEELERAARTIKEVAQA 470
Cdd:COG0156   325 ------GDAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 2.18e-76

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 242.85  E-value: 2.18e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  98 KKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454     1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 178 YSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEqeiedqkNPRKARvtRRFIVVEGLYMNTGTICPL 257
Cdd:cd06454    81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHFGISIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454   152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 338 SASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIsGLKVVGESFSPAFHLQLqestgsreEDVKLLQEIVN 417
Cdd:cd06454   231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIG--------DDPAKAVAFSD 301

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1435040549 418 HCMDRSIALTQARY---LEKEEKclpppsIRVVVTVEQTDEELERAARTIKEV 467
Cdd:cd06454   302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
PLN02483 PLN02483
serine palmitoyltransferase
 96-471 7.46e-54

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 188.05  E-value: 7.46e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  96 NGKKCVNFASFNFLGLLD-----DPRVkaaaLVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFAT 170
Cdd:PLN02483   98 KTRRCLNLGSYNYLGFAAadeycTPRV----IESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYAT 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 171 IASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEIEDQknPRKARVTRRFIV-VEGLYM 249
Cdd:PLN02483  174 NSTIIPALIGKGGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLREQIAEGQ--PRTHRPWKKIIViVEGIYS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 250 NTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDIDLISANMENSLASIGGFCCGRSFVIDHQR 329
Cdd:PLN02483  252 MEGELCKLPEIVAVCKKYKAYVYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAGSKELIQYLK 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 330 LSGQGYCFSASL-PPLLAAAAIEALNIMEE---NPGIFSV--LREKCKRIHKALQGIsGLKVVGESFSPAFHLQLQESTG 403
Cdd:PLN02483  332 RTCPAHLYATSMsPPAVQQVISAIKVILGEdgtNRGAQKLaqIRENSNFFRSELQKM-GFEVLGDNDSPVMPIMLYNPAK 410

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435040549 404 ----SREedvkllqeivnhCMDRSIALTQARYlekeeKCLPP--PSIRVVVTVEQTDEELERAARTIKEVAQAV 471
Cdd:PLN02483  411 ipafSRE------------CLKQNVAVVVVGF-----PATPLllARARICISASHSREDLIKALEVISEVGDLV 467
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 84-468 3.69e-49

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 172.65  E-value: 3.69e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  84 VVSGPPSHNIVVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAII 163
Cdd:PRK05958   25 PREGGAGRWLVVDGRRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRLVTGNSPAHEALEEELAEWFGAERALL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 164 YSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLkeqeiedqknpRKARVTRRFIV 243
Cdd:PRK05958  105 FSSGYAANLAVLTALAGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVDALEALL-----------AKWRAGRALIV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 244 VEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsIDDIDLIS-ANMENSLASIGGFCCGRS 322
Cdd:PRK05958  174 TESVFSMDGDLAPLAELVALARRHGAWLLVDEAHGTGVLGPQGRGLAAEAGL-AGEPDVILvGTLGKALGSSGAAVLGSE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 323 FVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGISglKVVGESFSPAFHLQLqest 402
Cdd:PRK05958  253 TLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPERRERLAALIARLRAGLRALG--FQLMDSQSAIQPLIV---- 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435040549 403 GSREEDVKLLQeivnHCMDRSIALTqarylekeekCLPPPS-------IRVVVTVEQTDEELERAARTIKEVA 468
Cdd:PRK05958  327 GDNERALALAA----ALQEQGFWVG----------AIRPPTvpagtsrLRITLTAAHTEADIDRLLEALAEAL 385
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 84-343 7.78e-46

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 164.21  E-value: 7.78e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  84 VVSGPPSHNI-VVNGKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAI 162
Cdd:PRK06939   27 VITSPQGADItVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMASVRFICGTQDLHKELEEKLAKFLGTEDAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 163 IYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQeiedqknpRKARVTRRFI 242
Cdd:PRK06939  107 LYSSCFDANGGLFETLLGKEDAIISDALNHASIIDGVRLCKAKRYRYANNDMADLEAQLKEA--------KEAGARHKLI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 243 VVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLA-SIGGFCCGR 321
Cdd:PRK06939  179 ATDGVFSMDGDIAPLPEICDLADKYDALVMVDDSHAVGFVGENGRGTVEHFGVM-DRVDIITGTLGKALGgASGGYTAGR 257

                         250       260
                  ....*....|....*....|..
gi 1435040549 322 SFVIDHQRLSGQGYCFSASLPP 343
Cdd:PRK06939  258 KEVIDWLRQRSRPYLFSNSLAP 279
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 98-343 1.54e-30

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 122.27  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  98 KKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIASAIPA 177
Cdd:PRK13392   46 RRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAGAGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALST 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 178 YSKR--GDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEIEDQKnprkarvtrrFIVVEGLYMNTGTIC 255
Cdd:PRK13392  126 LGKLlpGCVILSDALNHASMIEGIRRSGAEKQVFRHNDLADLEEQLASVDPDRPK----------LIAFESVYSMDGDIA 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 256 PLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGY 335
Cdd:PRK13392  196 PIEAICDLADRYNALTYVDEVHAVGLYGARGGGIAERDGL-MDRIDMIQGTLAKAFGCLGGYIAASADLIDFVRSFAPGF 274


                  ....*...
gi 1435040549 336 CFSASLPP 343
Cdd:PRK13392  275 IFTTALPP 282
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 3.04e-24

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 103.54  E-value: 3.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  98 KKCVNFASFNFLGLLDdPRVKAAALvslrkyGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEE--------AIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDTL-PAVAKAEK------DALAGGTRNLYGPTDGHPELREALAKFLGRSPvlkldreaAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 170 TIASAIPAYSK-RGDIVFVDRAACFAIQKGLQASRSDIQLFK-------HNDMADLERLLKEQeiedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 242 IVVEGLYMNTGTICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRGVTEHFGIsiDDIDLISAN-MENSLASIG-- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLA--EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 316 -GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFSVLREKCKRIHKALQGIsGLKVVGeSFSPAF 394
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 395 HLQLqestGSREEDVKLLQEIVNHCmdrSIALTQARYLEKeekclpPPSIRVVVTVeQTDEELERAARTI 464
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
101-343 1.80e-18

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 86.99  E-value: 1.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 101 VNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIASAIPAYSK 180
Cdd:PRK07179   57 IILQSNDYLNLSGHPDIIKAQIAALQEEGDSLVMSAVFLHDDSPKPQFEKKLAAFTGFESCLLCQSGWAANVGLLQTIAD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 181 RGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLkeqeiedqknprkarvtRRF----IVVEGLYMNTGTICP 256
Cdd:PRK07179  137 PNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQI-----------------ERHgpgiIVVDSVYSTTGTIAP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 257 LPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYC 336
Cdd:PRK07179  200 LADIVDIAEEFGCVLVVDESHSLGTHGPQGAGLVAELGLT-SRVHFITASLAKAFAGRAGIITCPRELAEYVPFVSYPAI 278


                  ....*..
gi 1435040549 337 FSASLPP 343
Cdd:PRK07179  279 FSSTLLP 285
PRK07505 PRK07505
hypothetical protein; Provisional
 97-317 7.40e-18

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 85.42  E-value: 7.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  97 GKKCVNFASFNFLGLLDDPRVKAAALVSLRKYGV-GTCGPRGFYgTFDVHLDLEDRLAKFMQTEEAIIYSYGFAT----- 170
Cdd:PRK07505   45 GHTFVNFVSCSYLGLDTHPAIIEGAVDALKRTGSlHLSSSRTRV-RSQILKDLEEALSELFGASVLTFTSCSAAHlgilp 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 171 -IASAIPAYSKRGDIVFvDRAA--CFAIQKGLQASRSDIQLFKHNDMADLERLLKEQEiedqknprkarvtRRFIVVEGL 247
Cdd:PRK07505  124 lLASGHLTGGVPPHMVF-DKNAhaSLNILKGICADETEVETIDHNDLDALEDICKTNK-------------TVAYVADGV 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435040549 248 YmNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRG-VTEHFGISIDDIDLISANMENSLASIGGF 317
Cdd:PRK07505  190 Y-SMGGIAPVKELLRLQEKYGLFLYIDDAHGLSIYGKNGEGyVRSELDYRLNERTIIAASLGKAFGASGGV 259
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 101-294 1.37e-17

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 84.06  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 101 VNFASFNFLGLLDDPRVKAAALVSLRKY-------GVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIAS 173
Cdd:PRK05937    7 IDFVTNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 174 AIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIQLFKHNDMADLERLLKEQeiedqknpRKARVTRRFIVVEGLYMNTGT 253
Cdd:PRK05937   87 LCAHLSSVTDYVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLESC--------RQRSFGRIFIFVCSVYSFKGT 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1435040549 254 ICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFG 294
Cdd:PRK05937  159 LAPLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGFCHSLG 199
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 98-342 1.13e-15

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 78.95  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549  98 KKCVNFASFNFLGLLDDPRVKAAALVSLRKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMQTEEAIIYSYGFATIASAIPA 177
Cdd:PLN02955  102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAANMAAMVA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 178 YSKRGDIVFVD-------RAACF-------AIQKGLQ-ASR---SDIQLFKHNDMADLERLLKEQEIEdqknprkarvtR 239
Cdd:PLN02955  182 IGSVASLLAASgkplkneKVAIFsdalnhaSIIDGVRlAERqgnVEVFVYRHCDMYHLNSLLSSCKMK-----------R 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435040549 240 RFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISiDDIDLISANMENSLASIGGF-- 317
Cdd:PLN02955  251 KVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCE-ADVDLCVGTLSKAAGCHGGFia 329

                         250       260
                  ....*....|....*....|....*
gi 1435040549 318 CCGRSFVIDHQRlsGQGYCFSASLP 342
Cdd:PLN02955  330 CSKKWKQLIQSR--GRSFIFSTAIP 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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