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Conserved domains on  [gi|1418205691|ref|XP_025303867|]
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monoglyceride lipase isoform X1 [Canis lupus dingo]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 56-328 2.23e-104

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PHA02857:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 276  Bit Score: 307.20  E-value: 2.23e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  56 LVNADGQYLFCRYWKPPGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDVL 135
Cdd:PHA02857    5 MFNLDNDYIYCKYWKPITYPKALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 136 QHVDFMQKDYPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVlaNPESATTFKVLAAKVLNLVLPNMSLGPIDS 215
Cdd:PHA02857   85 QHVVTIKSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLV--NAEAVPRLNLLAAKLMGIFYPNKIVGKLCP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 216 SVLSRNKTEVDLYNSDPLICRAGLKVCFGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSqDKTL 295
Cdd:PHA02857  163 ESVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC-NREI 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1418205691 296 KIYEGAYHVLHKELPEVTNSVFREINMWVSQRI 328
Cdd:PHA02857  242 KIYEGAKHHLHKETDEVKKSVMKEIETWIFNRV 274
 
Name Accession Description Interval E-value
PHA02857 PHA02857
monoglyceride lipase; Provisional
 56-328 2.23e-104

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 307.20  E-value: 2.23e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  56 LVNADGQYLFCRYWKPPGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDVL 135
Cdd:PHA02857    5 MFNLDNDYIYCKYWKPITYPKALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 136 QHVDFMQKDYPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVlaNPESATTFKVLAAKVLNLVLPNMSLGPIDS 215
Cdd:PHA02857   85 QHVVTIKSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLV--NAEAVPRLNLLAAKLMGIFYPNKIVGKLCP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 216 SVLSRNKTEVDLYNSDPLICRAGLKVCFGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSqDKTL 295
Cdd:PHA02857  163 ESVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC-NREI 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1418205691 296 KIYEGAYHVLHKELPEVTNSVFREINMWVSQRI 328
Cdd:PHA02857  242 KIYEGAKHHLHKETDEVKKSVMKEIETWIFNRV 274
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 75-309 1.86e-92

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 275.25  E-value: 1.86e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  75 PKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDVLQHVDFMQKDYPGLPVFLLG 154
Cdd:pfam12146   3 PRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 155 HSMGGAIAILTAAERPSHFSGMVLISPLVLANPESATTFKVLAAKVLNLVLPNMSL-GPIDSSVLSRNKTEVDLYNSDPL 233
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLAPPILKLLAKLLGKLFPRLRVpNNLLPDSLSRDPEVVAAYAADPL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1418205691 234 ICRaGLKVCFGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVLHKEL 309
Cdd:pfam12146 163 VHG-GISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLNEP 237
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
55-326 1.93e-50

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 167.49  E-value: 1.93e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  55 HLVNADGQYLFCRYWKPPGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDV 134
Cdd:COG2267     7 TLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVDDL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 135 LQHVDFMQKDyPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVLANPESATTFKVLAAkvlnlvlpnmslgpid 214
Cdd:COG2267    87 RAALDALRAR-PGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADPLLGPSARWLRA---------------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 215 ssvlsrnktevdlynsdplicraglkvcfgiqllnavTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAkSQDKT 294
Cdd:COG2267   150 -------------------------------------LRLAEALARIDVPVLVLHGGADRVVPPEAARRLAARL-SPDVE 191

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1418205691 295 LKIYEGAYHVLHKELPEvtNSVFREINMWVSQ 326
Cdd:COG2267   192 LVLLPGARHELLNEPAR--EEVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 106-308 3.29e-05

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 45.16  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 106 VFAHDHVGHGQSEGE---RMVVSDFHVFIRDVLQHV--------------------DFMQKDYPGLPVFLLGHSMGGAIA 162
Cdd:TIGR01607  77 VYGLDLQGHGESDGLqnlRGHINCFDDLVYDVIQYMnrindsiilenetksddesyDIVNTKENRLPMYIIGLSMGGNIA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 163 ILT------AAERPSH--------FSGMVLISPLVLANPESATTFKVLAAKVLNLVLPNMSLGPIDSsvLSRNKTEVDLY 228
Cdd:TIGR01607 157 LRLlellgkSNENNDKlnikgcisLSGMISIKSVGSDDSFKFKYFYLPVMNFMSRVFPTFRISKKIR--YEKSPYVNDII 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 229 NSDPLICRAGLKVCFGIQLLNAVTRVE---RALPKlTLPFLLLQGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVL 305
Cdd:TIGR01607 235 KFDKFRYDGGITFNLASELIKATDTLDcdiDYIPK-DIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVI 313


                  ...
gi 1418205691 306 HKE 308
Cdd:TIGR01607 314 TIE 316
Esterase_713_like-2 cd12809
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 149-182 1.98e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214008  Cd Length: 280  Bit Score: 42.60  E-value: 1.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1418205691 149 PVFLLGHSMGGAIAILTAAERPSHFSGMVLISPL 182
Cdd:cd12809   172 PAILITHSQGGPFGWLAADARPDLVKAIVAIEPS 205
 
Name Accession Description Interval E-value
PHA02857 PHA02857
monoglyceride lipase; Provisional
 56-328 2.23e-104

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 307.20  E-value: 2.23e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  56 LVNADGQYLFCRYWKPPGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDVL 135
Cdd:PHA02857    5 MFNLDNDYIYCKYWKPITYPKALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 136 QHVDFMQKDYPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVlaNPESATTFKVLAAKVLNLVLPNMSLGPIDS 215
Cdd:PHA02857   85 QHVVTIKSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLV--NAEAVPRLNLLAAKLMGIFYPNKIVGKLCP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 216 SVLSRNKTEVDLYNSDPLICRAGLKVCFGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSqDKTL 295
Cdd:PHA02857  163 ESVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC-NREI 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1418205691 296 KIYEGAYHVLHKELPEVTNSVFREINMWVSQRI 328
Cdd:PHA02857  242 KIYEGAKHHLHKETDEVKKSVMKEIETWIFNRV 274
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 75-309 1.86e-92

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 275.25  E-value: 1.86e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  75 PKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDVLQHVDFMQKDYPGLPVFLLG 154
Cdd:pfam12146   3 PRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 155 HSMGGAIAILTAAERPSHFSGMVLISPLVLANPESATTFKVLAAKVLNLVLPNMSL-GPIDSSVLSRNKTEVDLYNSDPL 233
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLAPPILKLLAKLLGKLFPRLRVpNNLLPDSLSRDPEVVAAYAADPL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1418205691 234 ICRaGLKVCFGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVLHKEL 309
Cdd:pfam12146 163 VHG-GISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLNEP 237
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
55-326 1.93e-50

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 167.49  E-value: 1.93e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  55 HLVNADGQYLFCRYWKPPGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDV 134
Cdd:COG2267     7 TLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFDDYVDDL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 135 LQHVDFMQKDyPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVLANPESATTFKVLAAkvlnlvlpnmslgpid 214
Cdd:COG2267    87 RAALDALRAR-PGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADPLLGPSARWLRA---------------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 215 ssvlsrnktevdlynsdplicraglkvcfgiqllnavTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAkSQDKT 294
Cdd:COG2267   150 -------------------------------------LRLAEALARIDVPVLVLHGGADRVVPPEAARRLAARL-SPDVE 191

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1418205691 295 LKIYEGAYHVLHKELPEvtNSVFREINMWVSQ 326
Cdd:COG2267   192 LVLLPGARHELLNEPAR--EEVLAAILAWLER 221
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 57-327 1.71e-39

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 142.58  E-value: 1.71e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  57 VNADGQYLFCRYWKP-PGTPKALIFVSHGAGEHCGRYDE-LAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDV 134
Cdd:PLN02385   67 VNSRGVEIFSKSWLPeNSRPKAAVCFCHGYGDTCTFFFEgIARKIASSGYGVFAMDYPGFGLSEGLHGYIPSFDDLVDDV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 135 LQHVDFMQ--KDYPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLV-----LANPESATTFKVLAAKVLnlvlPN 207
Cdd:PLN02385  147 IEHYSKIKgnPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCkiaddVVPPPLVLQILILLANLL----PK 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 208 MSLGP----IDSSVLSRNKTEVDLYNsdpLIC---RAGLKVcfGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKG 280
Cdd:PLN02385  223 AKLVPqkdlAELAFRDLKKRKMAEYN---VIAykdKPRLRT--AVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSV 297

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1418205691 281 AYLLMESAKSQDKTLKIYEGAYH-VLHKELPEVTNSVFREINMWVSQR 327
Cdd:PLN02385  298 SKFLYEKASSSDKKLKLYEDAYHsILEGEPDEMIFQVLDDIISWLDSH 345
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 61-332 6.50e-36

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 132.59  E-value: 6.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  61 GQYLFCRYWKP--PGTPKALIFVSHGAGEHCG-RYDELAQMLVGLELLVFAHDHVGHGQSEGERMVVSDFHVFIRDVLQH 137
Cdd:PLN02298   42 GLSLFTRSWLPssSSPPRALIFMVHGYGNDISwTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAYVPNVDLVVEDCLSF 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 138 VDFMQKD--YPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVLANPESATTFKVlaAKVLNLV---LPNMSLGP 212
Cdd:PLN02298  122 FNSVKQReeFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRPPWPI--PQILTFVarfLPTLAIVP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 213 ----IDSSVLSRNKTEVDLYNsdPLICRAGLKVCFGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESA 288
Cdd:PLN02298  200 tadlLEKSVKVPAKKIIAKRN--PMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPDVSRALYEEA 277

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1418205691 289 KSQDKTLKIYEGAYH-VLHKELPEVTNSVFREINMWVSQRIGAAA 332
Cdd:PLN02298  278 KSEDKTIKIYDGMMHsLLFGEPDENIEIVRRDILSWLNERCTGKA 322
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 35-335 3.07e-34

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 129.63  E-value: 3.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  35 MPEESSPRRTPQSVPYqnlphlvNADGQYLFCRYWKP-PGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVG 113
Cdd:PLN02652  101 MVEDGEGTRWATSLFY-------GARRNALFCRSWAPaAGEMRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIG 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 114 HGQSEGERMVVSDFHVFIRDVLQHVDFMQKDYPGLPVFLLGHSMGGAIaILTAAERPS---HFSGMVLISPLVLANPESA 190
Cdd:PLN02652  174 HGGSDGLHGYVPSLDYVVEDTEAFLEKIRSENPGVPCFLFGHSTGGAV-VLKAASYPSiedKLEGIVLTSPALRVKPAHP 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 191 TTFKVlaAKVLNLVLPNMSLGPIDSS--VLSRNKTEVDLYNSDPLICRAGLKVCFGIQLLNAVTRVERALPKLTLPFLLL 268
Cdd:PLN02652  253 IVGAV--APIFSLVAPRFQFKGANKRgiPVSRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVL 330

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1418205691 269 QGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVLHKElPEvTNSVFREINMWVSQRIGAAAGTG 335
Cdd:PLN02652  331 HGTADRVTDPLASQDLYNEAASRHKDIKLYDGFLHDLLFE-PE-REEVGRDIIDWMEKRLDLVNGSA 395
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
72-316 1.10e-24

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 100.40  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  72 PGTPKALIFVsHGAGehCGRYD--ELAQMLVGLELLVFAHDHVGHGQSEGErMVVSDFHVFIRDVLQHVDFMQKDYPglP 149
Cdd:COG1647    12 EGGRKGVLLL-HGFT--GSPAEmrPLAEALAKAGYTVYAPRLPGHGTSPED-LLKTTWEDWLEDVEEAYEILKAGYD--K 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 150 VFLLGHSMGGAIAILTAAERPsHFSGMVLISPLVLANPESAttfkvLAAKVLNLVLPnmSLGPIDSSVLSRNKTEVDlYN 229
Cdd:COG1647    86 VIVIGLSMGGLLALLLAARYP-DVAGLVLLSPALKIDDPSA-----PLLPLLKYLAR--SLRGIGSDIEDPEVAEYA-YD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 230 SDPLICraglkvcfGIQLLNAVTRVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVLH--K 307
Cdd:COG1647   157 RTPLRA--------LAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITldK 228


                  ....*....
gi 1418205691 308 ELPEVTNSV 316
Cdd:COG1647   229 DREEVAEEI 237
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 47-304 1.06e-20

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 89.59  E-value: 1.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  47 SVPYQNLpHLVNADGQYLFCRYWKPPGTPKAL--IFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGERMVV 124
Cdd:COG1073     7 KVNKEDV-TFKSRDGIKLAGDLYLPAGASKKYpaVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPREE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 125 SDFHvfIRDVLQHVDFM--QKDYPGLPVFLLGHSMGGAIAILTAAERPsHFSGMVLISPlvLANPESAttFKVLAAKVLN 202
Cdd:COG1073    86 GSPE--RRDARAAVDYLrtLPGVDPERIGLLGISLGGGYALNAAATDP-RVKAVILDSP--FTSLEDL--AAQRAKEARG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 203 LVLPNMSLGPidssvlsrNKTEVDLYNSDplicraglkvcfgiqlLNAVTRVEralpKLTLPFLLLQGSADRLCDSKGAY 282
Cdd:COG1073   159 AYLPGVPYLP--------NVRLASLLNDE----------------FDPLAKIE----KISRPLLFIHGEKDEAVPFYMSE 210

                         250       260
                  ....*....|....*....|..
gi 1418205691 283 LLMEsAKSQDKTLKIYEGAYHV 304
Cdd:COG1073   211 DLYE-AAAEPKELLIVPGAGHV 231
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 54-319 5.64e-19

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 84.28  E-value: 5.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  54 PHLVNADGQYLFCRYWKPPGTPkaLIFVsHGAGEHCGRYDELAQMLvGLELLVFAHDHVGHGQSEGERMVVSdFHVFIRD 133
Cdd:COG0596     4 PRFVTVDGVRLHYREAGPDGPP--VVLL-HGLPGSSYEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYT-LDDLADD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 134 VLQHVDFMQKDypglPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVlanpesattfKVLAAkvlNLVLPNMSLGPI 213
Cdd:COG0596    79 LAALLDALGLE----RVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL----------AALAE---PLRRPGLAPEAL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 214 DSSVLSRNKTEvdlynsdplicraglkvcfgiqllnavtrVERALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKsqDK 293
Cdd:COG0596   142 AALLRALARTD-----------------------------LRERLARITVPTLVIWGEKDPIVPPALARRLAELLP--NA 190

                         250       260
                  ....*....|....*....|....*.
gi 1418205691 294 TLKIYEGAYHVLHKELPEVTNSVFRE 319
Cdd:COG0596   191 ELVVLPGAGHFPPLEQPEAFAAALRD 216
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
58-329 9.07e-19

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 83.91  E-value: 9.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  58 NADGQYLFCRYWKPPGTPKA-LIFVSHGAGEH-CGRYDELAQMLVGLELLVFAHDHVGHGQSEGERmvvsdFHVFIRDVL 135
Cdd:COG1506     4 SADGTTLPGWLYLPADGKKYpVVVYVHGGPGSrDDSFLPLAQALASRGYAVLAPDYRGYGESAGDW-----GGDEVDDVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 136 QHVDFM--QKDYPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPlvLANPESATTFKVLAAKVLNLVLPNMslgpi 213
Cdd:COG1506    79 AAIDYLaaRPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAG--VSDLRSYYGTTREYTERLMGGPWED----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 214 dssvlsrnktEVDLYNSDPLicraglkvcfgiqllnavtrveRALPKLTLPFLLLQGSADRLCDSKGAYLLMESAKSQ-- 291
Cdd:COG1506   152 ----------PEAYAARSPL----------------------AYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAgk 199

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1418205691 292 DKTLKIYEGAYHVLHKelpEVTNSVFREINMWVSQRIG 329
Cdd:COG1506   200 PVELLVYPGEGHGFSG---AGAPDYLERILDFLDRHLK 234
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 76-308 6.54e-13

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 67.53  E-value: 6.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  76 KALIFVsHGAGEHCGRYDELAQMLVGLELLVFAHDHVGHGQSEGeRMVVSDFHVFirDVLQHVDFMQKDYPGLPVFLLGH 155
Cdd:pfam00561   1 PPVLLL-HGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSR-PKAQDDYRTD--DLAEDLEYILEALGLEKVNLVGH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 156 SMGGAIAILTAAERPSHFSGMVLISPLVLAN-------------PESATTFKVLAAKVLNLVLPNMSLGPI---DSSVLS 219
Cdd:pfam00561  77 SMGGLIALAYAAKYPDRVKALVLLGALDPPHeldeadrfilalfPGFFDGFVADFAPNPLGRLVAKLLALLllrLRLLKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 220 RNKTEVDLYNSDPLIcrAGLKVCFGIQLLNAVTRVERA--LPKLTLPFLLLQGSADRLCDSKGAYLLmeSAKSQDKTLKI 297
Cdd:pfam00561 157 LPLLNKRFPSGDYAL--AKSLVTGALLFIETWSTELRAkfLGRLDEPTLIIWGDQDPLVPPQALEKL--AQLFPNARLVV 232

                         250
                  ....*....|.
gi 1418205691 298 YEGAYHVLHKE 308
Cdd:pfam00561 233 IPDAGHFAFLE 243
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 78-306 2.10e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 50.94  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  78 LIFVsHGAGEHcgrYDELAQmLVGLELLVFAHDHVGHGQSEGERMVVSDfhvfIRDVLQHVDFMQKDYPglpVFLLGHSM 157
Cdd:pfam12697   1 VVLV-HGAGLS---AAPLAA-LLAAGVAVLAPDLPGHGSSSPPPLDLAD----LADLAALLDELGAARP---VVLVGHSL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 158 GGAIAiLTAAERPSHFSgmVLISPLVLANPESATTFKVLAAKVLNLVLPNMSLGPIDSSVLSRNKTEVDLYNSDPLICRA 237
Cdd:pfam12697  69 GGAVA-LAAAAAALVVG--VLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALARLAA 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1418205691 238 GLKVCFGIQLlnavtrveRALPKLTLPFLLLqGSADRLCDskgAYLLMESAKSQDKTLKIYEGAYHVLH 306
Cdd:pfam12697 146 LLAALALLPL--------AAWRDLPVPVLVL-AEEDRLVP---ELAQRLLAALAGARLVVLPGAGHLPL 202
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
55-170 1.58e-06

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 48.42  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  55 HLVNADGQYLFCRYWKPPGT-PKALIFVSHGAGEHCGRYDELAQMLVGLELLVFA---HDHVGHGQSEGE---RMVVSDF 127
Cdd:COG0412     7 TIPTPDGVTLPGYLARPAGGgPRPGVVVLHEIFGLNPHIRDVARRLAAAGYVVLApdlYGRGGPGDDPDEaraLMGALDP 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1418205691 128 HVFIRDVLQHVDFM--QKDYPGLPVFLLGHSMGGAIAILTAAERP 170
Cdd:COG0412    87 ELLAADLRAALDWLkaQPEVDAGRVGVVGFCFGGGLALLAAARGP 131
PLN02578 PLN02578
hydrolase
 73-325 7.08e-06

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 47.14  E-value: 7.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  73 GTPKALIfvsHGAGE---HCgRYD--ELAQmlvglELLVFAHDHVGHGQSEgERMVVSDFHVFIRDVlqhVDFMqKDYPG 147
Cdd:PLN02578   86 GLPIVLI---HGFGAsafHW-RYNipELAK-----KYKVYALDLLGFGWSD-KALIEYDAMVWRDQV---ADFV-KEVVK 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 148 LPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPL------------VLANPESA-TTFKVLAAK------VLNLVLPNM 208
Cdd:PLN02578  152 EPAVLVGNSLGGFTALSTAVGYPELVAGVALLNSAgqfgsesrekeeAIVVEETVlTRFVVKPLKewfqrvVLGFLFWQA 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 209 SLGPIDSSVLS---RNKTEVDLY--------NSDP--------LICRAglkvcfgiqLLNAVT-RVERALPKLTLPFLLL 268
Cdd:PLN02578  232 KQPSRIESVLKsvyKDKSNVDDYlvesitepAADPnagevyyrLMSRF---------LFNQSRyTLDSLLSKLSCPLLLL 302

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1418205691 269 QGSADRLCDSKGAYLLmeSAKSQDKTLkIYEGAYHVLHKELPEVTNSVFREinmWVS 325
Cdd:PLN02578  303 WGDLDPWVGPAKAEKI--KAFYPDTTL-VNLQAGHCPHDEVPEQVNKALLE---WLS 353
PRK10749 PRK10749
lysophospholipase L2; Provisional
 91-303 8.76e-06

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 46.91  E-value: 8.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  91 RYDELAQMLVGLELLVFAHDHVGHGQS-----EGERMVVSDFHVFIRDVLQhvdFMQKDYPGLPV---FLLGHSMGGAIA 162
Cdd:PRK10749   69 KYAELAYDLFHLGYDVLIIDHRGQGRSgrlldDPHRGHVERFNDYVDDLAA---FWQQEIQPGPYrkrYALAHSMGGAIL 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 163 ILTAAERPSHFSGMVLISPL---VLANPESATTFKVLAAKVLNLVLPNMSLG-------PIDSSVLS----RNKTEVDLY 228
Cdd:PRK10749  146 TLFLQRHPGVFDAIALCAPMfgiVLPLPSWMARRILNWAEGHPRIRDGYAIGtgrwrplPFAINVLThsreRYRRNLRFY 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 229 NSDPLI---------CRAGLKVcfGIQLLNAVtrveralPKLTLPFLLLQGSADRLCDSKG------AYLLMESAKSQDK 293
Cdd:PRK10749  226 ADDPELrvggptyhwVRESILA--GEQVLAGA-------GDITTPLLLLQAEEERVVDNRMhdrfceARTAAGHPCEGGK 296

                         250
                  ....*....|
gi 1418205691 294 TLKIyEGAYH 303
Cdd:PRK10749  297 PLVI-KGAYH 305
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
130-181 2.00e-05

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 45.36  E-value: 2.00e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1418205691 130 FIRDVLQhvDFMQKDYPGLPVF--LLGHSMGGAIAILTAAERPSHFSGMVLISP 181
Cdd:COG2819   112 FLEEELK--PYIDKRYRTDPERtgLIGHSLGGLFSLYALLKYPDLFGRYIAISP 163
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 106-181 3.17e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 45.32  E-value: 3.17e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1418205691 106 VFAHDHVGHGQSeGERMVVSDFHVFIRDVLqhvDFMqkDYPGLP-VFLLGHSMGGAIAILTAAERPSHFSGMVLISP 181
Cdd:PRK14875  160 VIALDLPGHGAS-SKAVGAGSLDELAAAVL---AFL--DALGIErAHLVGHSMGGAVALRLAARAPQRVASLTLIAP 230
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 106-308 3.29e-05

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 45.16  E-value: 3.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 106 VFAHDHVGHGQSEGE---RMVVSDFHVFIRDVLQHV--------------------DFMQKDYPGLPVFLLGHSMGGAIA 162
Cdd:TIGR01607  77 VYGLDLQGHGESDGLqnlRGHINCFDDLVYDVIQYMnrindsiilenetksddesyDIVNTKENRLPMYIIGLSMGGNIA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 163 ILT------AAERPSH--------FSGMVLISPLVLANPESATTFKVLAAKVLNLVLPNMSLGPIDSsvLSRNKTEVDLY 228
Cdd:TIGR01607 157 LRLlellgkSNENNDKlnikgcisLSGMISIKSVGSDDSFKFKYFYLPVMNFMSRVFPTFRISKKIR--YEKSPYVNDII 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 229 NSDPLICRAGLKVCFGIQLLNAVTRVE---RALPKlTLPFLLLQGSADRLCDSKGAYLLMESAKSQDKTLKIYEGAYHVL 305
Cdd:TIGR01607 235 KFDKFRYDGGITFNLASELIKATDTLDcdiDYIPK-DIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVI 313


                  ...
gi 1418205691 306 HKE 308
Cdd:TIGR01607 314 TIE 316
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
71-303 4.37e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 44.71  E-value: 4.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  71 PPGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFAHDHVGH--GQSEGERMVVSDFHVF---------IRDVLQHVD 139
Cdd:COG4188    57 PAGGPFPLVVLSHGLGGSREGYAYLAEHLASHGYVVAAPDHPGSnaADLSAALDGLADALDPeelwerpldLSFVLDQLL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 140 FMQKDYPGLP-------VFLLGHSMGGAIAILTAAERPshfsgmvlisplvlanpeSATTFKVLAAKVLNLVLPNMSLGP 212
Cdd:COG4188   137 ALNKSDPPLAgrldldrIGVIGHSLGGYTALALAGARL------------------DFAALRQYCGKNPDLQCRALDLPR 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691 213 IDSSVlsrnktevdlynSDPLIcRAGLkvcfgiqLLNAVTR---VERALPKLTLPFLLLQGSADRlcDSKGAY---LLME 286
Cdd:COG4188   199 LAYDL------------RDPRI-KAVV-------ALAPGGSglfGEEGLAAITIPVLLVAGSADD--VTPAPDeqiRPFD 256

                         250
                  ....*....|....*..
gi 1418205691 287 SAKSQDKTLKIYEGAYH 303
Cdd:COG4188   257 LLPGADKYLLTLEGATH 273
YpfH COG0400
Predicted esterase [General function prediction only];
72-188 4.72e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 43.74  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  72 PGTPKALIFVSHGAGEHCGRYDELAQMLVGLELLVFA------HDHVGHG-----------QSEGERMVVSDFHVFIRDV 134
Cdd:COG0400     1 GGPAAPLVVLLHGYGGDEEDLLPLAPELALPGAAVLAprapvpEGPGGRAwfdlsflegreDEEGLAAAAEALAAFIDEL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1418205691 135 LQHVDFmqkdyPGLPVFLLGHSMGGAIAILTAAERPSHFSGMVLISPLVLANPE 188
Cdd:COG0400    81 EARYGI-----DPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPGEEA 129
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 71-191 1.49e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.68  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  71 PPGTPKALIFVSHGAG------EHCGRYDELA---QMLV----GLELL------VFAHDHVGHGQSEgermvvsdfHVFI 131
Cdd:COG3509    48 DGGAPLPLVVALHGCGgsaadfAAGTGLNALAdreGFIVvypeGTGRApgrcwnWFDGRDQRRGRDD---------VAFI 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1418205691 132 RDVLQHvdfMQKDYPGLP--VFLLGHSMGGAIAILTAAERPSHFSGMVLIS--PLVLANPESAT 191
Cdd:COG3509   119 AALVDD---LAARYGIDPkrVYVTGLSAGGAMAYRLACEYPDVFAAVAPVAglPYGAASDAACA 179
COG4099 COG4099
Predicted peptidase [General function prediction only];
67-194 1.76e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 42.26  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418205691  67 RYWKPPG-TPKA---LIFVSHGAGEhcgRYDEL-AQMLVGLELLVFAHDHVGHG------Q-SEGERMVVSDFHvfiRDV 134
Cdd:COG4099    36 RLYLPKGyDPGKkypLVLFLHGAGE---RGTDNeKQLTHGAPKFINPENQAKFPaivlapQcPEDDYWSDTKAL---DAV 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1418205691 135 LQHVDFMQKDYPGLP--VFLLGHSMGGAIAILTAAERPSHFSGMVLISPlvLANPESATTFK 194
Cdd:COG4099   110 LALLDDLIAEYRIDPdrIYLTGLSMGGYGTWDLAARYPDLFAAAVPICG--GGDPANAANLK 169
Esterase_713_like-2 cd12809
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 149-182 1.98e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214008  Cd Length: 280  Bit Score: 42.60  E-value: 1.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1418205691 149 PVFLLGHSMGGAIAILTAAERPSHFSGMVLISPL 182
Cdd:cd12809   172 PAILITHSQGGPFGWLAADARPDLVKAIVAIEPS 205
Lipase_3 cd00519
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ...
 127-168 4.20e-04

Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238287 [Multi-domain]  Cd Length: 229  Bit Score: 41.31  E-value: 4.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1418205691 127 FHVFIRDVLQHVDFMQKDYPGLPVFLLGHSMGGAIAILTAAE 168
Cdd:cd00519   107 YKSLYNQVLPELKSALKQYPDYKIIVTGHSLGGALASLLALD 148
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
131-168 7.29e-04

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 40.25  E-value: 7.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1418205691 131 IRDVLQHVDFMQKDYPGLPVFLLGHSMGGAIAILTAAE 168
Cdd:COG3571    63 DAAWRAVIAALRARLAGLPLVIGGKSMGGRVASMLAAE 100
Lipase cd00741
Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and ...
 127-168 1.24e-03

Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.


Pssm-ID: 238382 [Multi-domain]  Cd Length: 153  Bit Score: 39.02  E-value: 1.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1418205691 127 FHVFIRDVLQHVDFMQKD----YPGLPVFLLGHSMGGAIAILTAAE 168
Cdd:cd00741     3 FYKAARSLANLVLPLLKSalaqYPDYKIHVTGHSLGGALAGLAGLD 48
Lipase_3 pfam01764
Lipase (class 3);
145-193 2.99e-03

Lipase (class 3);


Pssm-ID: 396362 [Multi-domain]  Cd Length: 139  Bit Score: 37.63  E-value: 2.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1418205691 145 YPGLPVFLLGHSMGGAIAILTAAerpshfsgMVLISPLVLANPESATTF 193
Cdd:pfam01764  60 YPDYSIVVTGHSLGGALASLAAL--------DLVENGLRLSSRVTVVTF 100
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 130-183 3.49e-03

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 38.60  E-value: 3.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1418205691 130 FIRDVLqhVDFMQKDYPGLPVF--LLGHSMGGAIAILTAAERPSHFSGMVLISPLV 183
Cdd:pfam00756  92 FLTQEL--PPLLDANFPTAPDGraLAGQSMGGLGALYLALKYPDLFGSVSSFSPIL 145
PRK10673 PRK10673
esterase;
114-179 6.06e-03

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 37.79  E-value: 6.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1418205691 114 HGQSEgeRMVVSDFHVFIRDVLQHVDFMQKDypglPVFLLGHSMGGAIAILTAAERPSHFSGMVLI 179
Cdd:PRK10673   53 HGLSP--RDPVMNYPAMAQDLLDTLDALQIE----KATFIGHSMGGKAVMALTALAPDRIDKLVAI 112
Lip2 COG3675
Predicted lipase [Lipid transport and metabolism];
107-168 6.83e-03

Predicted lipase [Lipid transport and metabolism];


Pssm-ID: 442891 [Multi-domain]  Cd Length: 266  Bit Score: 37.81  E-value: 6.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1418205691 107 FAHDHVGHGQSEGerMVVSDFHVFIRDVLQH-VDFMQKDYPGLPVFLLGHSMGGAIAILTAAE 168
Cdd:COG3675    48 AAQVPYPFAKTGG--KVHRGFYRALQSLRELlEDALRPLSPGKRLYVTGHSLGGALATLAAAD 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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