|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-376 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 595.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 170 SISGFICMGTSFVCLVLIKNEPSDVGLPNIEPGTTKGK-KGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQ 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLSLYGNPRHVLLLSMMAGMSVSMYLFRVTITSDSPK 328
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSE 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1394717157 329 LWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:cd17343 321 LFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVG 368
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-376 |
1.78e-125 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 366.32 E-value: 1.78e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 18 FVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 98 STVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP-IVAALMALSYDWRTTLSISGFIC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 177 MGTSFVCLVLIKNEPSDVGLPNIEP--------GTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQ 248
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEmpneepdgDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFRVTITSDspK 328
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAAN--P 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1394717157 329 LWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:TIGR00881 311 LMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLG 358
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-376 |
1.00e-99 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 299.96 E-value: 1.00e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 170 SISGFICMGTSFVCLVLIKNEPsdvglpniepgttkgkkglsgdhstlaelllsPYLWVLSSGYLVVFGVKTCCTDWGQL 249
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFRVtitSDSPKL 329
Cdd:cd17312 209 YLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--------LFGGRRAPIAVIYMLLMTLSLALFWF---FPHNKL 277
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1394717157 330 WILILGAIFGFSSYGPIALFGVIANE-SAPSNLCGTSHAIVALMANAG 376
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLG 325
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
2-376 |
3.34e-72 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 231.52 E-value: 3.34e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 2 MDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:PRK11663 13 IDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 82 SGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAL 161
Cdd:PRK11663 93 IGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIAL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 162 SYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNI--------EPGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGY 233
Cdd:PRK11663 173 HYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVgewrhdalELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 234 LVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMsv 313
Cdd:PRK11663 253 VLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK--------LFNGNRGPMNLIFAAGI-- 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1394717157 314 smyLFRVTITSDSPKLWILILGAIF---GFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:PRK11663 323 ---LLSVGSLWLMPFASYVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLG 385
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-376 |
2.83e-63 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 206.49 E-value: 2.83e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 170 SISGFICMGTSFVCLVLIKNEPsdvglpniepgttkgkkglsgdhstlaelllsPYLWVLSSGYLVVFGVKTCCTDWGQL 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVS---MYLFRVTitsds 326
Cdd:cd17488 209 YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--------LFKGNRGPMNLIFALGLLVSvgaLWLVPVH----- 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1394717157 327 pKLWIL-ILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:cd17488 276 -SYWLLaTCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLG 325
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-373 |
1.12e-59 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 198.23 E-value: 1.12e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVF----SWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA---LS 162
Cdd:cd17345 81 INILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLaifGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 163 YDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIE---------PGTTKGKKGLSGDHSTLAELLLSPYLWVLS--- 230
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEeykgdypeeADGEEEEQELSAWEIFVKYVLKNKLLWYIAian 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 231 -SGYLVVFGVktccTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMA 309
Cdd:cd17345 241 vFVYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK--------LFKGRRAPTGIIFMI 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394717157 310 GMSVSMylfrVTITSDSPKLWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMA 373
Cdd:cd17345 309 LVIVAL----IVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFG 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-376 |
7.63e-49 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.51 E-value: 7.63e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 3 DKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSS 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 83 GLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALS 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 163 YDWRTTLSISGFICMgtsfvclvliknepsdvglpniepgttkgkkglsgdhstlaeLLLSPYLWVLSSGYLVVFGVKTC 242
Cdd:COG2271 161 FGWRAAFLILGLPGL------------------------------------------LLALLRFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 243 CTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglslYGNPRHVLLLSMMAGMSVSMYLFRVTi 322
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLLALL- 268
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1394717157 323 tsdSPKLWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:COG2271 269 ---PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLG 319
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
2-376 |
2.26e-45 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 161.16 E-value: 2.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 2 MDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEiELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:TIGR00712 17 IDPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 82 SGLLLVGIVNVVFS---W-SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGG-LGPIVA 156
Cdd:TIGR00712 96 AGLILSAAVMLLMGfvpWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGiPPLLVL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 157 ALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIEP--------GTTKGKKGLSGDHSTLAELLLSPYLWV 228
Cdd:TIGR00712 176 LGMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEyrndypddYNEKAEQELTAKEIFMQYVLPNKLLWY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 229 LSSGYLVVFGVKTCCTDWGQLFLIQERGqSALVGSSYMSAL-EIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSM 307
Cdd:TIGR00712 256 IAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDK--------VFKGNRGATGVFF 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394717157 308 MAGMSVSMYLFRVTITSDSpkLWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:TIGR00712 327 MTLVTIAVIVYWMNPAGNP--LVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLG 393
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
2-371 |
8.07e-37 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 138.69 E-value: 8.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 2 MDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEiELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:PRK11273 19 IDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 82 SGLLLVGIVNVVFSW----SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL-GPIVA 156
Cdd:PRK11273 98 AGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 157 ALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIEPG--------TTKGKKGLSGDHSTLAELLLSPYLWV 228
Cdd:PRK11273 178 LGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYkndypddyNEKHEQELTAKQIFMQYVLPNKLLWY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 229 LSSGYLVVFGVKTCCTDWGQLFLiQERGQSALVGSSYMSAL-EIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSM 307
Cdd:PRK11273 258 IAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDK--------VFRGNRGATGVFF 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394717157 308 MAGMSVSMYLFRVTiTSDSPKLWILILGAIfGFSSYGPIALFGVIANESAPSNLCGTSHAIVAL 371
Cdd:PRK11273 329 MTLVTIATIVYWLN-PAGNPTVDMACMIVI-GFLIYGPVMLIGLHALELAPKKAAGTAAGFTGL 390
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-376 |
9.10e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 115.36 E-value: 9.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 9 YRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTT 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 169 LSISGFICMGTSFVCLVLIKNEPSDVGLPNiepgttkgkkglSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQ 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAA------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFRVTITSdspk 328
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLLALALGS---- 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1394717157 329 LWILILGAIFGFSSYGPI--ALFGVIANESAPSNLcGTSHAIVALMANAG 376
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGngAVFALVPDIFPTKNA-GAVYGLVGAAGGLG 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-376 |
3.76e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.82 E-value: 3.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 17 MFVGYTLYYFNRKTFSFVMP-AIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 96 WSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 176 CMGTSFVCLVLIKNEPSdvglpniePGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVkTCCTDWGQLFlIQER 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES--------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF-FGLLTYLPLY-QEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 256 GQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLslygnprhVLLLSMMAGMSVSMYLFRVTITSdspkLWILILG 335
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL--------LLALLLLILAALGLLLLSLTLSS----LWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1394717157 336 AIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-376 |
2.12e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.14 E-value: 2.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 7 SYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLL 86
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 87 VGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWR 166
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 167 TTLSISGFICmgtsFVCLVLIKnepsdVGLPNIEPGTTKGKKGlsgdhsTLAELLLSPYLWVLSSGYLVVFGVKTCCTDW 246
Cdd:COG2814 165 WVFLVNAVLA----LLALLLLL-----RLLPESRPAARARLRG------SLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 247 GQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFRVTITSds 326
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLLALAGSL-- 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1394717157 327 pkLWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:COG2814 297 --WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-376 |
3.18e-23 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 99.18 E-value: 3.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 170 SISGFICMGTSFVCLVLIknePSDVGLpniepgttkgkkglsgdhsTLAELLLSPYLWVLSSgylvvfgvktcctdWGQL 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT--------------WLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFrvtITSDSPKL 329
Cdd:cd17319 205 YLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR--------LLRGARRLVIIIGLLLAAVGLLLA---YLTTSPVV 273
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1394717157 330 WILILGAIFGFsSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:cd17319 274 AVILLSLAGFG-IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLG 319
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-376 |
6.33e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.65 E-value: 6.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 17 MFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSW 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 97 SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAAL--MALSYDWRTTLSISGF 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIlaSSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 175 ICMGTSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLSgdhstlaELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQE 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK-------RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 255 RGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLSLYGnprhvllLSMMAGMSVSMYLFRVTItsdspklWILIL 334
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG-------LLLMALGLALLLLAPSLL-------LLLLL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1394717157 335 GAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLG 341
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-364 |
3.89e-21 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 93.46 E-value: 3.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 36 PAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQG 115
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 116 LGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPsdvg 195
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 196 lpniEPGTTKGKKglSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLV 275
Cdd:cd17475 176 ----AASAATESA--STLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 276 GSIAAGYLSDRAVArvglslyGNPRHVLLLSM--MAGMSVSMYLFrvtitSDSPKLWILILGAIF-GFSSYGPIALFGVI 352
Cdd:cd17475 250 GRIGLGRVSDRVFG-------GRRRPVLVITAaiAAAALLVLSLL-----SPGTPLWLLVLLLILlGLFAIGWNGLYLTL 317
|
330
....*....|..
gi 1394717157 353 ANESAPSNLCGT 364
Cdd:cd17475 318 VAESAGPEQAGT 329
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-360 |
1.70e-19 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 89.72 E-value: 1.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVV 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 94 FSWS-----STVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAlsydwrTT 168
Cdd:PRK09556 111 FGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGA------NY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 169 L---SISGF------ICMGTSFVCLVLIKNEPSDVGLPNIEP--GTTKGKKGLSGDHSTLAE-------LLLSPYLWVLS 230
Cdd:PRK09556 185 FfdgHVIGMfifpsiIALIIGFIGLRYGSDSPEELGWGKAEEifGEPISEEDKETESTDMTKwqifveyVLKNPVIWLLC 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 231 SGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLslygnprhVLLLSM-MA 309
Cdd:PRK09556 265 FANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRAL--------VACIALaLI 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1394717157 310 GMSVSMYLFRVTITSDSPKLWILilgaifGFSSYGPIALFGVIANESAPSN 360
Cdd:PRK09556 337 IFTLGVYQHATSEYMYLASLFAL------GFLVFGPQLLIGVAAVGFVPKK 381
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-355 |
1.02e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 77.70 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 28 RKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLW 107
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 108 FLNGLAQ--GLGWPPCGKVLRKWFEPSQfGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLV 185
Cdd:cd17355 99 GLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 186 LIKNEPSDVGLPNIEPGTTKGKKglsgdhSTLAELLLSPYLWVLSSGYLVVfGVKTCCTDWGQLFLIQERGQSALVGSSY 265
Cdd:cd17355 178 LLRRRPADLALRAYDDASPASPG------STLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 266 MSALEIGGLVGSIAAGYLSDRavarvglslyGNPRHVLLLSMMAGMSVSMYLfrvtITSDSPKLWILILGAIFGFSSYGP 345
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDR----------YSPRRLLAASYALRALGLALL----LLLPFPPLALLLFAALFGLGWGAT 316
|
330
....*....|
gi 1394717157 346 IALFGVIANE 355
Cdd:cd17355 317 VPLTAALAAR 326
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-341 |
1.26e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.61 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 114 QGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSD 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 194 vglpniepgttkgkKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLiQERGQSALVGSSYMSALEIGG 273
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1394717157 274 LVGSIAAGYLSDRavarvglslYGNPRHVLLLsmMAGMSVSMYLFRVTITSDSPKLWILILGAIFGFS 341
Cdd:COG2807 264 IPGSLLVPLLADR---------LGDRRPLLLL--LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGL 320
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-344 |
1.61e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 1.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 13 IFTAMFVGYTLYYfnrkTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNV 92
Cdd:cd17325 1 LSLALFLDMLGYG----IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 93 VFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLsis 172
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 173 gFICMGTSFVCLVLIKnepsdVGLPNIEPGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLI 252
Cdd:cd17325 154 -LVCAALALLALVLAL-----LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 253 QERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFRVtitsdSPKLWIL 332
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPL-----ATSFWLL 291
|
330
....*....|..
gi 1394717157 333 ILGAIFGFSSYG 344
Cdd:cd17325 292 LLLLALLGLGLG 303
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
10-158 |
4.85e-12 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 66.57 E-value: 4.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEE---------------------IELDKDD----LGLITSSQSAAYAISK 64
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEwtpsnsntsielheetwnanpLFPSQDDaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 65 FISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVF------SGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWW 138
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180
....*....|....*....|
gi 1394717157 139 AILSTSMNLAGGLGPIVAAL 158
Cdd:cd17342 161 GLWSACASVGNIIGALLASS 180
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-347 |
1.52e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 65.33 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 17 MFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSW 96
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 97 SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA-LSYDWRTTLSISGFI 175
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 176 cmgtSFVCLVLIKnepsdVGLPNIEPGTTKGKKGLSGDHSTLAELLLS-----PYLWVLSSGYLVVFGVkTCCTDWGQLF 250
Cdd:cd17328 164 ----GVLLAILLL-----LFVREPPRGAAEGGVMAKSTATSFLADLKAlaknpSFILSTLGFTAVSFVT-GALAFWAPTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 251 LiqERGQSALVGSSYMSALE------IGGLVGSIAAGYLSDRAVARvglslygNPRHVLLLSMMaGMSVS---MYLFRVT 321
Cdd:cd17328 234 F--LRAFGVGDLSSADVGLIfgaitcIAGVLGVLLGGILADRLRRK-------TPRADPLVCAV-GLLAAapfLFLALVL 303
|
330 340
....*....|....*....|....*..
gi 1394717157 322 ITSDSPKLWILI-LGAIFGFSSYGPIA 347
Cdd:cd17328 304 ALSNLLLAWVLLfLGEFLLSLNWAPVF 330
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
10-191 |
1.58e-11 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 65.03 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFV-----------MPAIMEEIE---------LDKDD----LGLITSSQSAAYAISKF 65
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVksvlhpncsalIPPPNIVLNnttwcgwapFDGKNgtelLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 66 ISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSgLWF------LNGLAQGLGWPPCGKVLRKWFEPSQFGTWWA 139
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHS-LWYfvvvqiLAGLFQSTGWPSVVACVGNWFGKGKRGLIMG 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1394717157 140 ILSTSMNLAGGLGPIVAAlMALSYDWRTTLSISGFICMGTSFVC-LVLIKNEP 191
Cdd:cd17344 160 IWNSHTSVGNILGSLIAG-IFVSSAWGLSFIVPGIIIAAMGVLVfLFLVEHPP 211
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-364 |
3.72e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.86 E-value: 3.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVV 93
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 94 FSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA----LSYDWRTTL 169
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 170 SISGFicmgTSFVCLVLIKNEPsdvglpniEP---GTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCC--- 243
Cdd:cd17371 161 LLGAL----PALLVLFIRRFVK--------EPpqwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYygi 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 244 TDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglslYGNPRHVLLLSMMAGMSVSMYLFrvtiT 323
Cdd:cd17371 229 TTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF----L 295
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1394717157 324 SDSPKLwILILGAIFGFSSYGPIALFGVIANESAPSNLCGT 364
Cdd:cd17371 296 PLSPTL-ILILGFPLGFFASGPFSGMGAYLTELFPTAVRAT 335
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-286 |
5.12e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.33 E-value: 5.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 114 QGLGWPPCGKVLRkWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA---LSYDWRTTLSISGFICMGTSFVCLVlikne 190
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLLLLLALLFLR----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 191 psdVGLPNIEPGTTKGkkglSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALE 270
Cdd:COG0738 184 ---SKLPEIEEEEEEA----AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250
....*....|....*.
gi 1394717157 271 IGGLVGSIAAGYLSDR 286
Cdd:COG0738 257 GGMTIGRFLGGFLLKR 272
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
32-364 |
7.00e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.14 E-value: 7.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 32 SFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNG 111
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 112 LAQGLGWPPCgKVLRKWFEPSQF-GTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFIcmgTSFVCLVLIKNE 190
Cdd:TIGR00895 117 LGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIA---PLLLLLLLMRFL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 191 P----------------------------SDVGLPnIEPGTTKGKKGLSGDHSTLAELLLSPYLWVLSS-GYLVVFGVkt 241
Cdd:TIGR00895 193 PesidflvskrpetvrrivnaiapqmqaeAQSALP-EQKSTQGTKRSVFKALFQGKTARITVLLWLLYFmLLVGVYFL-- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 242 ccTDWGQlFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygNPRHVLLLSMMAGMSVSMYLFRVT 321
Cdd:TIGR00895 270 --TNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGSTLF 336
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1394717157 322 ITSDspklwILILGAIFGFSSYGPIALFGVIANESAPSNLCGT 364
Cdd:TIGR00895 337 SPTL-----LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRAT 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-187 |
1.10e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.59 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 12 VIFTAMFVGYTLYYFNRKTFSFVMpaiMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVN 91
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYA---AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 92 VVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSI 171
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 1394717157 172 SGFICMGTSFVCLVLI 187
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-360 |
1.14e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.19 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 114 QGLGWPPCGKVLRKwFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKnepsd 193
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 194 VGLPNIEPGTTKGKKGLSGDHSTLAELLLspyLWVLSSGYLVVFGVKTCCTdwgqlFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLL---LIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 274 LVGSIAAGYLSDRavarvglslyGNPRHVLLLSmMAGMSVSMYLFRVTitsdsPKLWILILGAIFGFSSYGPIALFGVIA 353
Cdd:cd17478 244 AIGTLIGGPLSDR----------FGRRRVIIAS-LLLAAPFLLLFLLT-----PGIWSYILLVLAGFLLFASFPVTVVLA 307
|
....*..
gi 1394717157 354 NESAPSN 360
Cdd:cd17478 308 QELLPGN 314
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-239 |
2.41e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.98 E-value: 2.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 170 SISGFIcmgtSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGV 239
Cdd:COG0477 172 LINAPL----GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-376 |
9.11e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.46 E-value: 9.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIE--LDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 92 VVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMN----LAGGLGPIVAALMALSYDWRT 167
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 168 TLSISGFICMGTsfvclvliknepsdvglpniepgttkgkkglsgdhstlaeLLLSPYLWVLSSGYLVVFGVKTCCTDWG 247
Cdd:cd17316 161 LFLIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 248 QLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFrvTITSDSP 327
Cdd:cd17316 201 PTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL--FYLLSGS 267
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1394717157 328 KLWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLG 316
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-360 |
3.91e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.48 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIknepsd 193
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 194 vglpniePGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17324 175 -------PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 274 LVGSIAAGYLSDRAVARVglslygnprhvlLLSMMAGMSVSMYLFrvTITSDSPKLWILILgAIFGFSSYGPIALFGVIA 353
Cdd:cd17324 248 VVGSPLAGRLADRGGRRA------------LLIALLLLAAALLLL--TLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRV 312
|
....*..
gi 1394717157 354 NESAPSN 360
Cdd:cd17324 313 LRLAPEA 319
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-188 |
8.35e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 8.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 12 VIFTAMFVGYTLYYFNRKTFSFVMPAIM-EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSAR--WLFSSGLLLVG 88
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTT 168
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|
gi 1394717157 169 LSISGFICMGTSFVCLVLIK 188
Cdd:COG2271 340 FLLLAALALLAALLALLLLR 359
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-297 |
1.19e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.09 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 47 DDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGwPPCGKVLR 126
Cdd:cd17333 31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 127 KWFEPSQFGTWWAILSTSMNLAGGLGP-IVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIEPGTtk 205
Cdd:cd17333 110 GALFEESSATRLNVLHGFFGLGALIGPlIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGA-- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 206 gkkglsgDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSD 285
Cdd:cd17333 188 -------FSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
250
....*....|..
gi 1394717157 286 RAVARVGLSLYG 297
Cdd:cd17333 261 RIKPHTLLVLSG 272
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-364 |
5.95e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 5.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALsYDWRTTLSISgFICMGTSFVCLVLIKNEPSd 193
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLL-AALIPVAFLAILFLLPEPK- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 194 vglpniepgtTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17474 178 ----------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 274 LVGSIAAGYLSDRAVarvglslygnPRHVLLLSMMAGMSVSMYLFRVTitsdsPKLWILILG-AIFGFSSYGPIALFGVI 352
Cdd:cd17474 248 ALGSLFVGRLLKKRF----------GARRILVIGLLLYALSLLLLGFV-----PSLALLLIAiVLFGLGLGLNLPLLTTL 312
|
330
....*....|..
gi 1394717157 353 ANESAPSNLCGT 364
Cdd:cd17474 313 VTELAPEEERGT 324
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-186 |
8.83e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 8.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIM-EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 89 IVNVVFSWSS-TVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIvaaLMALSYDWRT 167
Cdd:COG2223 283 LGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPL---LFGALLDATG 359
|
170
....*....|....*....
gi 1394717157 168 TLSISGFICMGTSFVCLVL 186
Cdd:COG2223 360 SYTAAFLVFAVLALVALVL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-208 |
8.90e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 8.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 26 FNRKTFSFVMPAIM----EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVT 101
Cdd:cd17329 10 LNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 102 VFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA-LSYDWRTTLSISGFICmgtS 180
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLlYSFRLLFLAAAVLFLL---A 166
|
170 180
....*....|....*....|....*...
gi 1394717157 181 FVCLVLIKNEPSDVGLPNIEPGTTKGKK 208
Cdd:cd17329 167 ALVLLFLLPETRPKRRAAEKTEILRGYK 194
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-186 |
9.35e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 9.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 49 LGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKW 128
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1394717157 129 FEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVL 186
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-344 |
2.29e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.12 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 32 SFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNG 111
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 112 LAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLsisgFICMGTSFVCLVLIKnep 191
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----LLGGVPPLILLPLLR--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 192 sdvglpniepgttkgkkglsgdhSTLAelllspyLWVLS-SGYLVVFGVKTcctdWGQLfLIQERGQSALVGSSYMSALE 270
Cdd:cd17365 172 -----------------------GTLL-------LWVTFfMGLLLVYLLNS----WLPK-LMVEAGYSLSQALTITLLLN 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394717157 271 IGGLVGSIAAGYLSDRavarvglslyGNPRHVLLLSMMAGMsVSMYLFrvtITSDSPKLWILILGAIFGFSSYG 344
Cdd:cd17365 217 IGGVIGSLLLGWLADR----------FGPKRVLALFFALGA-VSLALL---GVSPASLVLLYVLVFLAGACVNG 276
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-188 |
2.53e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.62 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 17 MFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSW 96
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 97 --SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGF 174
Cdd:cd17380 84 laYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170
....*....|....
gi 1394717157 175 ICMGTSFVCLVLIK 188
Cdd:cd17380 164 LGLLWALVWLIYLP 177
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-286 |
4.39e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 4.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 30 TFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARW-------LFSSGLLLVGIVNvvfswsSTVTV 102
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKailiggiLFGLGFILSAFAI------SLPLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 103 FSGLWFLNGLAQGLGWPPCGKVLRKWFePSQFGtwwaiLSTSMNLAG-GLG-----PIVAALMAlSYDWRTTLSISGFIC 176
Cdd:cd17353 95 FLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGslifsPLIAYLIN-TVGVPTTFLILGIIF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 177 MGTSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLSgdHSTLAELLLSPYLWVLssgYLVVFgvktCCTDWGQL------- 249
Cdd:cd17353 168 LIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR--DYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakp 238
|
250 260 270
....*....|....*....|....*....|....*..
gi 1394717157 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDR 286
Cdd:cd17353 239 IGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK 275
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-286 |
5.03e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.93 E-value: 5.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 12 VIFTAMFVGYTLYYFNRKTFS--FVMpAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISnaAVM-GMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTsmnlAGGLGPIVAALMALS------- 162
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYA----AAGLGSIFGGLLAYGvfkilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 163 ---YDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIE---------PGTTKGKKGLSGDHSTLAELLLSPYLWVLS 230
Cdd:cd17327 160 gglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEekelaverlRANQTGKGDQKFKWKQIKEAFKDPRTWLLF 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1394717157 231 SGYLVVFGVKTCCTdwGQLFLIQERGQSALVGSSYMS-ALEIGGLVGSIAAGYLSDR 286
Cdd:cd17327 240 LFFFCSQITNNGIS--NFLPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDR 294
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-376 |
1.19e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.70 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 35 MPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQ 114
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 115 GLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICmgtsFVCLVLIKNepsdv 194
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG----LVALLLART----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 195 glpniepgttkgkkgLSGdhSTLAELLLSpylwVLSSGYLVVFgvktcctdwgQLFLIQERGQSALVGSSYMSALEIGGL 274
Cdd:cd17321 170 ---------------FSG--AVLAAFLLG----AALGGLLFLL----------PLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 275 VGSIAAGYLSDRAVARvglslygnprhVLLLSMMAGMSVSMYLFRVTITSDSPKLWILILgAIFGFSSYGPIALFGVIAN 354
Cdd:cd17321 219 VAAPLAGRLADRFGPR-----------LVLVAGLLLTAVGLLLLALLGADSSVWLLLPGL-VLLGLGLGLFATPLTNAAL 286
|
330 340
....*....|....*....|..
gi 1394717157 355 ESAPSNLCGTSHAIVALMANAG 376
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLG 308
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-376 |
1.24e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWL-----FSSGLLLVG 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTT 168
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 169 LSISGfICMGTSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLS---GDHSTLAELLLSPYLWVLSSGYLVVFgvktcctd 245
Cdd:cd06173 161 FAINA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRylrRSPLLRLLLLALALFALLGGALTVLL-------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 246 wgqLFLIQERGQSALVGSSYMSALE-IGGLVGSIAAGYLSDRavarvglslygNPRHVLLLSMMAGMSVSMYLFRVtits 324
Cdd:cd06173 232 ---PLLAKEVLGGGAAGYGLLLAAFgVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGL---- 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1394717157 325 dSPKLWILILGAIFGFSSYGPI-ALFGVIANESAPSNLCGTSHAIVALMANAG 376
Cdd:cd06173 294 -SPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGA 345
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-151 |
1.85e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEI-ELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1394717157 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL 151
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
14-160 |
2.42e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEI-ELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNV 92
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1394717157 93 VFSW---SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLG-PIVAALMA 160
Cdd:cd17503 260 LLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGtALLATLLT 331
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-167 |
3.76e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.18 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 35 MPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLF--SSGLLLVGIVNVVFSWSSTVTVFSGLwfLNGL 112
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFltALALFTLGSLLCGLAPNLASLIIFRI--LQGF 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1394717157 113 AQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRT 167
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRW 151
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-186 |
4.90e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 4.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 13 IFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQ--MSARWLFSSGLLLVGIV 90
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 91 NVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLG-PIVAALMALSYDWRTTL 169
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDYDAAF 343
|
170
....*....|....*..
gi 1394717157 170 SISGFICMGTSFVCLVL 186
Cdd:cd17352 344 YFCGACLLLSGVLLFLL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-186 |
8.78e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.04 E-value: 8.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 50 GLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWF 129
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1394717157 130 EPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVL 186
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-176 |
1.32e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.50 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 47 DDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVtvfSGLW-----FLNGLAQGLGWPPC 121
Cdd:TIGR00894 76 ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG---GIALvvfcrVIQGLAQGSVSPAT 152
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1394717157 122 GKVLRKWFEPSQFGTWwailsTSMNLAG-GLGPIVAalmalsydwrttLSISGFIC 176
Cdd:TIGR00894 153 HKIIVKWAPPKERSRL-----LGMSTSGfQLGTFIF------------LPISGWLC 191
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-376 |
1.38e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17477 18 LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAlSYDWRTTLSISGFICMGTSFVCLVLIKNepsd 193
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAAVLLLLALVPLLLTRRAA---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 194 vglPNIEPGTtkgkkglSGDHSTLAELLLSPYLWVLSSGYLVvfgvkTCCTDWGQLFLIQErGQSALVGSSYMSALEIGG 273
Cdd:cd17477 173 ---PEIEEAE-------SISLRRLLRIAPLALLGAFVAGFLE-----GAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 274 LVGSIAAGYLSDRAvarvglslygNPRHVLLLSMMAGMSVSMYLFRVTITSdspkLWILILGAIFGFSSYGPIALFGVIA 353
Cdd:cd17477 237 LLLQWPLGWLADRF----------DRRRVLLGCALLGALAALLLPLVPGLP----LALLVLLFLWGGAAGPLYTLALALA 302
|
330 340
....*....|....*....|...
gi 1394717157 354 NESAPSNLCGTSHAIVALMANAG 376
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLG 325
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-176 |
2.57e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 45 DKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVN----VVFSWSSTVTVFsgLWFLNGLAQGLGWPP 120
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTlltpLAARGGYGALIV--LRILQGLAQGVTFPA 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1394717157 121 CGKVLRKWFEPSQFGTwwaiLSTSMNLAGGLGPIVaalmalsydwrtTLSISGFIC 176
Cdd:cd17318 132 MHALWAKWAPPLERSR----LTSIAYSGSQFGTVI------------AMPLSGFLC 171
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
16-192 |
2.71e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 16 AMFVGYTLYYFNRKTFSFVMPAIMEEIeLDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFS 95
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 96 WSSTVTVFSGLWFLNGLA---QGLGWPPCGKVLrkwfEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYD--WRTTLS 170
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGagtQGLGAAVASELV----PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFY 156
|
170 180
....*....|....*....|..
gi 1394717157 171 ISGFICmGTSFVCLVLIKNEPS 192
Cdd:cd06179 157 INAIFN-ALALILLFFFYHPPP 177
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
35-295 |
3.19e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.16 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 35 MPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQ 114
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 115 GLG---WPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGpivAALMALSYDWRTTLSISGFICMGTSfvcLVLIKNEP 191
Cdd:cd17393 102 GALdvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG---AAAIGAGVSPGVHLLAAAVLLLLAA---LVAIRALL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 192 SDVGLPNIEPGTTKGKKGLsgdhstlaeLLLSPYLWVLssGYLVVFG--VKTCCTDWGQLFLIQERGQSALVGSSYMSAL 269
Cdd:cd17393 176 PGTGEAAEDRPDGAGKPGF---------LLPNRLLLLL--GLLALAAalAEGAAADWSALYLRDVLGASAALAALGYAVF 244
|
250 260 270
....*....|....*....|....*....|
gi 1394717157 270 EIGGLVGSIAAGYL----SDRAVARVGLSL 295
Cdd:cd17393 245 SLAMTVGRLFGDRLvdrfGDVAVLRAGALL 274
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
11-344 |
3.48e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.10 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 11 TVIFTAMFVgytlyYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIV 90
Cdd:cd17323 3 IISFLTFVV-----TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 91 NVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTls 170
Cdd:cd17323 78 QIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWI-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 171 isGFICMGTSFVCLVLIknepsdvglpniepgttkgkkglsgdhstlaeLLLSPYLWVLSSGYLVVFGVKTCCTDWGQLF 250
Cdd:cd17323 156 --FWFLAIISGFCLILI--------------------------------FLFLPIVLLLGLYVGLVYAILYLFLTAFPYV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394717157 251 LIQERGQSAL-VGSSYMSALeIGGLVGSIAAGYLSDRAVARVGLSLYGNPR-HVLLLSMMAG---MSVSMYLFRVTITSD 325
Cdd:cd17323 202 FGEVYGFSPGeVGLMYLPIG-IGALIGSIIGGRLSDYYYRRLKKKNGGKPEpEARLPPAFIGaflFPIGLFIFGWTIYPH 280
|
330
....*....|....*....
gi 1394717157 326 SPKLWILILGAIFGFSSYG 344
Cdd:cd17323 281 IHWIVPIIGSAFFGFGLML 299
|
|
| |
