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Conserved domains on  [gi|2024409239|ref|XP_025006416|]
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7-dehydrocholesterol reductase isoform X1 [Gallus gallus]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 50-474 2.29e-90

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 281.64  E-value: 2.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239  50 PLIVYYFimscdqYQCSLTDPLINLLMGNKHLSDIWN--KTPSLTY--------TAAGIYAAWVAFQVILYVFVPdfchk 119
Cdd:pfam01222  21 PVFMLYL------NGCSGFFMLMFFLPKSFDIAVLMNfiKDPSLMVfpglewerYLWTVFLLWYFFQAVFYLTLP----- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 120 flpgyvGGVQEGAVTPAGVVNKYEINGLQAWIITHVLwFANAYYFHYFSPTIIFDNWIPLLWCANILGYVVSTFAMIKGY 199
Cdd:pfam01222  90 ------GKVVEGLPLSNGRKLPYKINAFWSFLLTLAA-IGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAIYLYVRSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 200 FFPTNAKDC--KFTGNFFYDYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGHVTNSMILVNVLQG 277
Cdd:pfam01222 163 KAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLNQL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 278 IYVLDYFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQL-CTANAIGILALGLVGYYIFRMTNHQ 356
Cdd:pfam01222 242 LYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELgWSTYAVAIYALLLCGYYIFRSANSQ 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 357 KDLFRRTNGNCKIwgKKPDYIEcsymsvdgTKYYSKLLTSGFWGWARHFNYTGDLMGSLAYCLTCGFEHILPYFYIVYMT 436
Cdd:pfam01222 322 KNNFRTNPADPKL--IYLKYIQ--------TKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFA 391

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2024409239 437 ILLTHRCIRDEHRCYSKYGKDWKRYTAAVPYRLIPGLF 474
Cdd:pfam01222 392 VLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
50-474 2.29e-90

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 281.64  E-value: 2.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239  50 PLIVYYFimscdqYQCSLTDPLINLLMGNKHLSDIWN--KTPSLTY--------TAAGIYAAWVAFQVILYVFVPdfchk 119
Cdd:pfam01222  21 PVFMLYL------NGCSGFFMLMFFLPKSFDIAVLMNfiKDPSLMVfpglewerYLWTVFLLWYFFQAVFYLTLP----- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 120 flpgyvGGVQEGAVTPAGVVNKYEINGLQAWIITHVLwFANAYYFHYFSPTIIFDNWIPLLWCANILGYVVSTFAMIKGY 199
Cdd:pfam01222  90 ------GKVVEGLPLSNGRKLPYKINAFWSFLLTLAA-IGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAIYLYVRSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 200 FFPTNAKDC--KFTGNFFYDYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGHVTNSMILVNVLQG 277
Cdd:pfam01222 163 KAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLNQL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 278 IYVLDYFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQL-CTANAIGILALGLVGYYIFRMTNHQ 356
Cdd:pfam01222 242 LYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELgWSTYAVAIYALLLCGYYIFRSANSQ 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 357 KDLFRRTNGNCKIwgKKPDYIEcsymsvdgTKYYSKLLTSGFWGWARHFNYTGDLMGSLAYCLTCGFEHILPYFYIVYMT 436
Cdd:pfam01222 322 KNNFRTNPADPKL--IYLKYIQ--------TKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFA 391

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2024409239 437 ILLTHRCIRDEHRCYSKYGKDWKRYTAAVPYRLIPGLF 474
Cdd:pfam01222 392 VLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 391-473 1.64e-05

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 44.00  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 391 SKLLTSGFWGWARHFNYTGDLMGSLAYCLTCGfeHILPYFYIVYMTILLTHRCIRDEHRCYSKYGKDWKRYTAAVPyRLI 470
Cdd:COG2020    34 HRLVTTGPYRYVRHPMYLGFLLLLLGLALLLG--SLLALLLALLLLLLYVLRIRREERRLRARFGEEYRAYAARVP-RLI 110


                  ...
gi 2024409239 471 PGL 473
Cdd:COG2020   111 PRL 113
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
50-474 2.29e-90

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 281.64  E-value: 2.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239  50 PLIVYYFimscdqYQCSLTDPLINLLMGNKHLSDIWN--KTPSLTY--------TAAGIYAAWVAFQVILYVFVPdfchk 119
Cdd:pfam01222  21 PVFMLYL------NGCSGFFMLMFFLPKSFDIAVLMNfiKDPSLMVfpglewerYLWTVFLLWYFFQAVFYLTLP----- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 120 flpgyvGGVQEGAVTPAGVVNKYEINGLQAWIITHVLwFANAYYFHYFSPTIIFDNWIPLLWCANILGYVVSTFAMIKGY 199
Cdd:pfam01222  90 ------GKVVEGLPLSNGRKLPYKINAFWSFLLTLAA-IGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAIYLYVRSL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 200 FFPTNAKDC--KFTGNFFYDYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGHVTNSMILVNVLQG 277
Cdd:pfam01222 163 KAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLNQL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 278 IYVLDYFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQL-CTANAIGILALGLVGYYIFRMTNHQ 356
Cdd:pfam01222 242 LYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELgWSTYAVAIYALLLCGYYIFRSANSQ 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 357 KDLFRRTNGNCKIwgKKPDYIEcsymsvdgTKYYSKLLTSGFWGWARHFNYTGDLMGSLAYCLTCGFEHILPYFYIVYMT 436
Cdd:pfam01222 322 KNNFRTNPADPKL--IYLKYIQ--------TKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFA 391

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2024409239 437 ILLTHRCIRDEHRCYSKYGKDWKRYTAAVPYRLIPGLF 474
Cdd:pfam01222 392 VLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 391-473 1.64e-05

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 44.00  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024409239 391 SKLLTSGFWGWARHFNYTGDLMGSLAYCLTCGfeHILPYFYIVYMTILLTHRCIRDEHRCYSKYGKDWKRYTAAVPyRLI 470
Cdd:COG2020    34 HRLVTTGPYRYVRHPMYLGFLLLLLGLALLLG--SLLALLLALLLLLLYVLRIRREERRLRARFGEEYRAYAARVP-RLI 110


                  ...
gi 2024409239 471 PGL 473
Cdd:COG2020   111 PRL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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