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Conserved domains on  [gi|1389908296|ref|XP_024920960|]
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plectin-like isoform X13 [Cynoglossus semilaevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 815-891 1.16e-39

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


:

Pssm-ID: 465730  Cd Length: 78  Bit Score: 142.74  E-value: 1.16e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  815 SWQYLMRDIHIIKTWNISMFKTLRVEEYRLALRNLEQHYQDFLRDSQDSQMFGAEDRMQVESNYNKANQHYNTMVTS 891
Cdd:pfam18373    2 SWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
PTZ00121 super family cl31754
MAEBL; Provisional
 1244-2057 1.17e-35

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 151.06  E-value: 1.17e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1244 VNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKE-EERRKMAEIQAELDKQKQMAEAHAKSVAKAEqealelkm 1322
Cdd:PTZ00121  1060 AEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKaEEAKKTETGKAEEARKAEEAKKKAEDARKAE-------- 1131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1323 kmkeEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAEL 1402
Cdd:PTZ00121  1132 ----EARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARK 1207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1403 QELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQA 1482
Cdd:PTZ00121  1208 AEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE 1287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1483 EEEKIRQIRVVEEVAQksaATQLQTKAmsfsEQTTKLEESLKKEQgnvlKLQEEADKLKKQQKEANTAREEAEQELEiwr 1562
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKK---ADEAKKKA----EEAKKADEAKKKAE----EAKKKADAAKKKAEEAKKAAEAAKAEAE--- 1353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1563 QKANEALRLRLQAEEEAQKKSHAQEEAEkqklEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEC 1642
Cdd:PTZ00121  1354 AAADEAEAAEEKAEAAEKKKEEAKKKAD----AAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1643 IRlKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLE-----DELNKVRSEMDSLLQMKINAEKASmvntEKSKQLLE 1717
Cdd:PTZ00121  1430 KK-KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEeakkaDEAKKKAEEAKKADEAKKKAEEAK----KKADEAKK 1504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1718 SEALKMKqlADEAARmrsvAEEAKKQRQIAEEEAARQRSEAEKILKEKLA-AINEATRLKT-----EAEMALKAKEAENE 1791
Cdd:PTZ00121  1505 AAEAKKK--ADEAKK----AEEAKKADEAKKAEEAKKADEAKKAEEKKKAdELKKAEELKKaeekkKAEEAKKAEEDKNM 1578

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1792 RLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDS-----ELGRQKNIVEETLKQKKVVEEEIHiiKINFHKASK 1866
Cdd:PTZ00121  1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAkikaeELKKAEEEKKKVEQLKKKEAEEKK--KAEELKKAE 1656

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1867 EKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEE----VERLK 1942
Cdd:PTZ00121  1657 EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEnkikAEEAK 1736

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1943 KKAEDANKQKEKAEKEAEKqvvlaKEAAQKCTAAEQKAQDVLSKNKEDVLAQE--------------KLRDEFENAKKL- 2007
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEE-----KKKIAHLKKEEEKKAEEIRKEKEAVIEEEldeedekrrmevdkKIKDIFDNFANIi 1811

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2008 -------------AQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQR 2057
Cdd:PTZ00121  1812 eggkegnlvindsKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEK 1874
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 111-172 8.21e-35

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21189:

Pssm-ID: 469584  Cd Length: 105  Bit Score: 130.20  E-value: 8.21e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21189     44 PDLIDFRSVRNQSNRENLENAFNVAEKEFGVTRLLDPEDVDVPEPDEKSIITYVSSLYDVFP 105
PTZ00121 super family cl31754
MAEBL; Provisional
 1667-2531 5.56e-34

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 145.67  E-value: 5.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1667 KNEVNSTEKQR---KQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQllESEALKMKQLADEAARMRSV------- 1736
Cdd:PTZ00121  1063 KAHVGQDEGLKpsyKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEE--ARKAEEAKKKAEDARKAEEArkaedar 1140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1737 -AEEAKKQRQIAEEEAARQRSEAEKI---LKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAA 1812
Cdd:PTZ00121  1141 kAEEARKAEDAKRVEIARKAEDARKAeeaRKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKA 1220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1813 QHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKlkgiADETQKS-KLK 1891
Cdd:PTZ00121  1221 EDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK----AEEKKKAdEAK 1296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1892 AEEEAEKLKKLAAEEERRRKEAEEKVKritaaEEEAARQCKAAQEEVERLKKKAEdANKQKEKAEKEAEKQVVLAKEAAQ 1971
Cdd:PTZ00121  1297 KAEEKKKADEAKKKAEEAKKADEAKKK-----AEEAKKKADAAKKKAEEAKKAAE-AAKAEAEAAADEAEAAEEKAEAAE 1370

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1972 KCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAAlLRQKAEE---AEKQKKAAEnEAAKQAK 2048
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADE-AKKKAEEkkkADEAKKKAE-EAKKADE 1448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2049 AQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKEltvvklqldetdkqkvlldQELQ 2128
Cdd:PTZ00121  1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-------------------AEAK 1509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2129 RVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKmkslAEEAGRLSVEAEET 2208
Cdd:PTZ00121  1510 KKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKK----AEEDKNMALRKAEE 1585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2209 ARQRQiaesnlaeqralaEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEgfqkslea 2288
Cdd:PTZ00121  1586 AKKAE-------------EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-------- 1644

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2289 ERKRQLEASAEAEKLKLRVKELSlaqTKAEDEakkfKKQADEVKAQlQRTEKHTTEIVVQKLETQrlqstREADDLKSAI 2368
Cdd:PTZ00121  1645 EKKKAEELKKAEEENKIKAAEEA---KKAEED----KKKAEEAKKA-EEDEKKAAEALKKEAEEA-----KKAEELKKKE 1711

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2369 ADleeerkklkkeaeeLQRKSKEMANAqqEQIEQQKAElqqsfltekglLLKREKEVEGEKKRFEKQLEDEMKKAKALKD 2448
Cdd:PTZ00121  1712 AE--------------EKKKAEELKKA--EEENKIKAE-----------EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK 1764

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2449 EQErqrKLMEEERKKLQAIMDEAVrKQKEAEEEMKNKQREMDVLDKKRLEQEKQlAEENKKLREQLQTFEISSKTVSQTK 2528
Cdd:PTZ00121  1765 EEE---KKAEEIRKEKEAVIEEEL-DEEDEKRRMEVDKKIKDIFDNFANIIEGG-KEGNLVINDSKEMEDSAIKEVADSK 1839


                   ...
gi 1389908296 2529 ESQ 2531
Cdd:PTZ00121  1840 NMQ 1842
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 713-779 7.12e-21

SH3 domain; This entry represents an SH3 domain.


:

Pssm-ID: 407754  Cd Length: 65  Bit Score: 88.86  E-value: 7.12e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  713 QLKPRNptTPLKGKMPIQAVCDFKQMEITVHRGDECALLNNSNPFKWQVLNDTGSEASVPSICFLVP 779
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3961-3999 4.19e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 71.59  E-value: 4.19e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3961 LLEAQIATGGIIDPQESHRLPVETAYERGLFDEEMNEIL 3999
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 537-727 1.83e-14

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 75.56  E-value: 1.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  537 QLHAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAF 616
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  617 TAALQTQWSWLLQLCCCIETHLKENTAHFQFFTDVKEAEEKLKKMQDTMKRKYTCDrsiTVTRLEDLLQDAADEKEQLAE 696
Cdd:cd00176     81 LEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGK---DLESVEELLKKHKELEEELEA 157

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1389908296  697 FKTNLEALKRRAKTVIQLKPRNPTTPLKGKM 727
Cdd:cd00176    158 HEPRLKSLNELAEELLEEGHPDADEEIEEKL 188
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2978-3016 2.67e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.28  E-value: 2.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2978 FLEAQAATGFVIDPIKNERVPVDEAVKSGLVGPEIHERL 3016
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3642-3680 1.98e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 66.97  E-value: 1.98e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3642 LLEAQAATGFMIDPVKDELLTVDEAVRKGLVGPELHDKL 3680
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3385-3421 6.50e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 65.43  E-value: 6.50e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1389908296 3385 LLEAQLATGGIIDPASSHRVPTDVAIQRGYFSKQMAK 3421
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3309-3347 1.38e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.66  E-value: 1.38e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3309 LLEAQAATGFITDPVKDKKCSVDDAVKEGIVGPELHEKL 3347
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2652-2690 1.74e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.27  E-value: 1.74e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2652 LLEAQAASGFIVDPVKNKFLSVDEAVKDKVIGPELHDRL 2690
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4231-4269 4.24e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.12  E-value: 4.24e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 4231 LLEAQACTGGIIDPNTGEKFSVVDAMNKGLVDKIMVDRI 4269
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2728-2766 1.41e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 61.57  E-value: 1.41e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2728 FLDVQLATGGIIDPVNSHRVPLQTAYSQGQFDADMNKKL 2766
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3718-3756 1.48e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 61.57  E-value: 1.48e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3718 LLEAQNATGGYMDPEYYFRLPIDVAMQRGYINKETHERL 3756
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3054-3092 6.66e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 59.65  E-value: 6.66e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3054 LLEAQLSTGGIVDPVKSYRIPHEVACKRGYFDDKMSKTL 3092
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3885-3923 1.97e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 58.49  E-value: 1.97e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3885 LLEAQAATGYVIDPIKNLKLNVTEAVKMGIVGTEFKDKL 3923
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4307-4345 6.86e-09

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 53.87  E-value: 6.86e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 4307 FLEVQYLTGGLIEPDATNRVAIDEAVKKGTLDARTAQKL 4345
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4062-4090 4.95e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.86  E-value: 4.95e-07
                           10        20
                   ....*....|....*....|....*....
gi 1389908296 4062 IVDPESGKEMSVYEAYQKGLIDHQTYLEL 4090
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
2689-2725 1.08e-05

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 1.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2689 RLLSAERAATGFKDPYTGAKISLFEAMNKGLIEKEQA 2725
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3015-3051 1.12e-05

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 1.12e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3015 RLLSAEKAVSGYHDPYTGKKVSLFEALKLGLIKKDHG 3051
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3847-3885 1.19e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 45.01  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3847 YLEGSSCIAGVYVESSKDRLSIYQAMKKNMIRPGTAFEL 3885
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3346-3382 2.62e-05

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.62e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3346 KLLSAEKAITGYRDPYTGNKISLFQAMKKELVLREHA 3382
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
4195-4228 1.08e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  4195 EETGPIAGILDTDTLEKVSVTEAIHRNLVDNITG 4228
Cdd:smart00250    5 EAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2941-2976 2.17e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 41.16  E-value: 2.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1389908296 2941 LQGTPSIAGILDEPTKEKMPFYQAMKKEFLSPETAL 2976
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
PLEC smart00250
Plectin repeat;
3922-3953 5.51e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 5.51e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1389908296  3922 KLVSAERAVTGYKDPYSGKVISLFQAMKKGLI 3953
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
PRK01156 super family cl30905
chromosome segregation protein; Provisional
 990-1467 8.04e-03

chromosome segregation protein; Provisional


The actual alignment was detected with superfamily member PRK01156:

Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.58  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  990 LRSELDLTLKKMEQVYGLSSVYLDKLKTVDVVIRNTADAEETLKNYEARLRDV-SKVPSEQKEVEKHRS-QMKSMRSEAE 1067
Cdd:PRK01156   209 DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAeSDLSMELEKNNYYKElEERHMKIIND 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1068 ADQVMFDRLQDDLRKATTVHDKmTRIHSERDADLEHYRQLVNGL---------LERWQAVFAQIELRLRELDLLGRHMNS 1138
Cdd:PRK01156   289 PVYKNRNYINDYFKYKNDIENK-KQILSNIDAEINKYHAIIKKLsvlqkdyndYIKKKSRYDDLNNQILELEGYEMDYNS 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1139 YRDSYEWLIRWLTEARQRQEKIQAvPISDSRALREQLTDE-KKLLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYK 1217
Cdd:PRK01156   368 YLKSIESLKKKIEEYSKNIERMSA-FISEILKIQEIDPDAiKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNM 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1218 A-LQDPIASPLKKPKM-ECASDDIIQEYVNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEK--ASEKLKE--EERRKMAE 1291
Cdd:PRK01156   447 EmLNGQSVCPVCGTTLgEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEylESEEINKsiNEYNKIES 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1292 IQAEL----DKQKQMAEAHAKSVAKAEQ------EALELK-------------------MKMKEEASKRQDvaaDAEKQK 1342
Cdd:PRK01156   527 ARADLedikIKINELKDKHDKYEEIKNRykslklEDLDSKrtswlnalavislidietnRSRSNEIKKQLN---DLESRL 603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSLSDQEIKSKNQQLeDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEA---------- 1412
Cdd:PRK01156   604 QEIEIGFPDDKSYIDKSIREIENEA-NNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEItsrindiedn 682

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1413 -EKLRKAAQD-EAERLRKQVAEETQRKKNAEDElKRKSDAEK--EAAKQKQRALDDLQK 1467
Cdd:PRK01156   683 lKKSRKALDDaKANRARLESTIEILRTRINELS-DRINDINEtlESMKKIKKAIGDLKR 740
PLEC smart00250
Plectin repeat;
4343-4380 9.19e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 36.69  E-value: 9.19e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4343 QKLRDVSAYSKYLTCPKTKLKISYKDAMERSMTEEGTG 4380
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 815-891 1.16e-39

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 142.74  E-value: 1.16e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  815 SWQYLMRDIHIIKTWNISMFKTLRVEEYRLALRNLEQHYQDFLRDSQDSQMFGAEDRMQVESNYNKANQHYNTMVTS 891
Cdd:pfam18373    2 SWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
PTZ00121 PTZ00121
MAEBL; Provisional
 1244-2057 1.17e-35

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 151.06  E-value: 1.17e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1244 VNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKE-EERRKMAEIQAELDKQKQMAEAHAKSVAKAEqealelkm 1322
Cdd:PTZ00121  1060 AEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKaEEAKKTETGKAEEARKAEEAKKKAEDARKAE-------- 1131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1323 kmkeEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAEL 1402
Cdd:PTZ00121  1132 ----EARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARK 1207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1403 QELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQA 1482
Cdd:PTZ00121  1208 AEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE 1287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1483 EEEKIRQIRVVEEVAQksaATQLQTKAmsfsEQTTKLEESLKKEQgnvlKLQEEADKLKKQQKEANTAREEAEQELEiwr 1562
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKK---ADEAKKKA----EEAKKADEAKKKAE----EAKKKADAAKKKAEEAKKAAEAAKAEAE--- 1353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1563 QKANEALRLRLQAEEEAQKKSHAQEEAEkqklEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEC 1642
Cdd:PTZ00121  1354 AAADEAEAAEEKAEAAEKKKEEAKKKAD----AAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1643 IRlKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLE-----DELNKVRSEMDSLLQMKINAEKASmvntEKSKQLLE 1717
Cdd:PTZ00121  1430 KK-KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEeakkaDEAKKKAEEAKKADEAKKKAEEAK----KKADEAKK 1504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1718 SEALKMKqlADEAARmrsvAEEAKKQRQIAEEEAARQRSEAEKILKEKLA-AINEATRLKT-----EAEMALKAKEAENE 1791
Cdd:PTZ00121  1505 AAEAKKK--ADEAKK----AEEAKKADEAKKAEEAKKADEAKKAEEKKKAdELKKAEELKKaeekkKAEEAKKAEEDKNM 1578

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1792 RLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDS-----ELGRQKNIVEETLKQKKVVEEEIHiiKINFHKASK 1866
Cdd:PTZ00121  1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAkikaeELKKAEEEKKKVEQLKKKEAEEKK--KAEELKKAE 1656

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1867 EKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEE----VERLK 1942
Cdd:PTZ00121  1657 EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEnkikAEEAK 1736

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1943 KKAEDANKQKEKAEKEAEKqvvlaKEAAQKCTAAEQKAQDVLSKNKEDVLAQE--------------KLRDEFENAKKL- 2007
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEE-----KKKIAHLKKEEEKKAEEIRKEKEAVIEEEldeedekrrmevdkKIKDIFDNFANIi 1811

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2008 -------------AQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQR 2057
Cdd:PTZ00121  1812 eggkegnlvindsKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEK 1874
CH_PLEC-like_rpt2 cd21189
second calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family ...
 111-172 8.21e-35

second calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family includes plectin, dystonin and microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1). Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It could also bind muscle proteins such as actin to membrane complexes in muscle. Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409038  Cd Length: 105  Bit Score: 130.20  E-value: 8.21e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21189     44 PDLIDFRSVRNQSNRENLENAFNVAEKEFGVTRLLDPEDVDVPEPDEKSIITYVSSLYDVFP 105
PTZ00121 PTZ00121
MAEBL; Provisional
 1667-2531 5.56e-34

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 145.67  E-value: 5.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1667 KNEVNSTEKQR---KQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQllESEALKMKQLADEAARMRSV------- 1736
Cdd:PTZ00121  1063 KAHVGQDEGLKpsyKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEE--ARKAEEAKKKAEDARKAEEArkaedar 1140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1737 -AEEAKKQRQIAEEEAARQRSEAEKI---LKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAA 1812
Cdd:PTZ00121  1141 kAEEARKAEDAKRVEIARKAEDARKAeeaRKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKA 1220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1813 QHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKlkgiADETQKS-KLK 1891
Cdd:PTZ00121  1221 EDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK----AEEKKKAdEAK 1296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1892 AEEEAEKLKKLAAEEERRRKEAEEKVKritaaEEEAARQCKAAQEEVERLKKKAEdANKQKEKAEKEAEKQVVLAKEAAQ 1971
Cdd:PTZ00121  1297 KAEEKKKADEAKKKAEEAKKADEAKKK-----AEEAKKKADAAKKKAEEAKKAAE-AAKAEAEAAADEAEAAEEKAEAAE 1370

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1972 KCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAAlLRQKAEE---AEKQKKAAEnEAAKQAK 2048
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADE-AKKKAEEkkkADEAKKKAE-EAKKADE 1448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2049 AQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKEltvvklqldetdkqkvlldQELQ 2128
Cdd:PTZ00121  1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-------------------AEAK 1509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2129 RVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKmkslAEEAGRLSVEAEET 2208
Cdd:PTZ00121  1510 KKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKK----AEEDKNMALRKAEE 1585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2209 ARQRQiaesnlaeqralaEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEgfqkslea 2288
Cdd:PTZ00121  1586 AKKAE-------------EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-------- 1644

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2289 ERKRQLEASAEAEKLKLRVKELSlaqTKAEDEakkfKKQADEVKAQlQRTEKHTTEIVVQKLETQrlqstREADDLKSAI 2368
Cdd:PTZ00121  1645 EKKKAEELKKAEEENKIKAAEEA---KKAEED----KKKAEEAKKA-EEDEKKAAEALKKEAEEA-----KKAEELKKKE 1711

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2369 ADleeerkklkkeaeeLQRKSKEMANAqqEQIEQQKAElqqsfltekglLLKREKEVEGEKKRFEKQLEDEMKKAKALKD 2448
Cdd:PTZ00121  1712 AE--------------EKKKAEELKKA--EEENKIKAE-----------EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK 1764

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2449 EQErqrKLMEEERKKLQAIMDEAVrKQKEAEEEMKNKQREMDVLDKKRLEQEKQlAEENKKLREQLQTFEISSKTVSQTK 2528
Cdd:PTZ00121  1765 EEE---KKAEEIRKEKEAVIEEEL-DEEDEKRRMEVDKKIKDIFDNFANIIEGG-KEGNLVINDSKEMEDSAIKEVADSK 1839


                   ...
gi 1389908296 2529 ESQ 2531
Cdd:PTZ00121  1840 NMQ 1842
growth_prot_Scy NF041483
polarized growth protein Scy;
1266-2518 6.06e-31

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 134.95  E-value: 6.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEEERRKMAEIQAELdkqkqmaeaHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNI 1345
Cdd:NF041483    91 DAERELRDARAQTQRILQEHAEHQARLQAEL---------HTEAVQRRQQLDQELAERRQTVESHVNENVAWAEQLRART 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1346 QQELQHLKSLSDQEIksknqqlEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAaEAEKLRKAAQDEAer 1425
Cdd:NF041483   162 ESQARRLLDESRAEA-------EQALAAARAEAERLAEEARQRLGSEAESARAEAEAILRRARK-DAERLLNAASTQA-- 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1426 lrkqvaeetQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKirqirVVEEvAQKSAATQL 1505
Cdd:NF041483   232 ---------QEATDHAEQLRSSTAAESDQARRQAAELSRAAEQRMQEAEEALREARAEAEK-----VVAE-AKEAAAKQL 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1506 QTkAMSFSEQTTKleesLKKEQgnVLKLQEEAdklkkqQKEANTAREEAEQ-------ELEIWRQKANEALRlRLQAEEE 1578
Cdd:NF041483   297 AS-AESANEQRTR----TAKEE--IARLVGEA------TKEAEALKAEAEQaladaraEAEKLVAEAAEKAR-TVAAEDT 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1579 AQKKSHAQEEAEKQKLEAERDAKK--RGKAEEAALKQKEnAEKELDKQRKFAEQIAQQKLSA---------------EQE 1641
Cdd:NF041483   363 AAQLAKAARTAEEVLTKASEDAKAttRAAAEEAERIRRE-AEAEADRLRGEAADQAEQLKGAakddtkeyraktvelQEE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1642 CIRLKADfehAEQQRGLLDNELQRLKNE-----VNSTEKQRKQLEDELNKVRSEMDSLLQ-MKINAEKASMVNTEKSKQL 1715
Cdd:NF041483   442 ARRLRGE---AEQLRAEAVAEGERIRGEarreaVQQIEEAARTAEELLTKAKADADELRStATAESERVRTEAIERATTL 518

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1716 LESEALKMKQLADEAARMRSVAEE-AKKQRQIAEEEAARQRSEAEKILKEKLA-AINEATRLKTEAEMALKAKE------ 1787
Cdd:NF041483   519 RRQAEETLERTRAEAERLRAEAEEqAEEVRAAAERAARELREETERAIAARQAeAAEELTRLHTEAEERLTAAEealada 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1788 -AENERLKRQAEEEAYQrklLEDQAAqhkqdieEKITQLQTSSDSElgrqknivEETLKQKKVVEeeihiikinfhkASK 1866
Cdd:NF041483   599 rAEAERIRREAAEETER---LRTEAA-------ERIRTLQAQAEQE--------AERLRTEAAAD------------ASA 648

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1867 EKADLESELKKLKG-IADETQKSKLKAEEEAEKLKklAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQE--------- 1936
Cdd:NF041483   649 ARAEGENVAVRLRSeAAAEAERLKSEAQESADRVR--AEAAAAAERVGTEAAEALAAAQEEAARRRREAEEtlgsaraea 726

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1937 --EVERLKKKAEDANKQKEKAEKEAEKQVV-LAKEAAQKCT----AAEQKAQDVlsknkedvlaqeklRDEFENAKKLAQ 2009
Cdd:NF041483   727 dqERERAREQSEELLASARKRVEEAQAEAQrLVEEADRRATelvsAAEQTAQQV--------------RDSVAGLQEQAE 792

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2010 EAEKAkekaekeaalLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRkeaeeeaarrAAAEAAALKQKQQADAemskhk 2089
Cdd:NF041483   793 EEIAG----------LRSAAEHAAERTRTEAQEEADRVRSDAYAERER----------ASEDANRLRREAQEET------ 846

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2090 kEAEQALQQKSqvekeltvVKLQLDETDKQKVLLDQELQRVKGEVNDAFkqkSQVEVELARVRIQM-EELVKLKLKIEEE 2168
Cdd:NF041483   847 -EAAKALAERT--------VSEAIAEAERLRSDASEYAQRVRTEASDTL---ASAEQDAARTRADArEDANRIRSDAAAQ 914

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2169 NRRLMQKDKDSTQKLLAE---EAEKMKSLA-EEAGRLSVEAEETARQRQIAESNLAEQ-RALAEKILKekmQAIQEATKL 2243
Cdd:NF041483   915 ADRLIGEATSEAERLTAEaraEAERLRDEArAEAERVRADAAAQAEQLIAEATGEAERlRAEAAETVG---SAQQHAERI 991

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2244 KAEAEKLqkqKDQAQETAKRLQEDKQQIQQRLDKETEgfqkslEAERKRQLEASAEAEKLKLRV-----KELSLAQTKAE 2318
Cdd:NF041483   992 RTEAERV---KAEAAAEAERLRTEAREEADRTLDEAR------KDANKRRSEAAEQADTLITEAaaeadQLTAKAQEEAL 1062

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2319 DEAKKFKKQADE-VKAQLQRTEKHTTEIVVQKlETQRLQSTREADDL-------KSAIADLEEERKKLKKEA-----EEL 2385
Cdd:NF041483  1063 RTTTEAEAQADTmVGAARKEAERIVAEATVEG-NSLVEKARTDADELlvgarrdATAIRERAEELRDRITGEieelhERA 1141

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2386 QRKSKEMANAQQEQIEQ--QKAELQQSFLTEKGLLLKREKEVEGEKKRFekqleDEMKKAKALKDEQERQRKLMEEERKK 2463
Cdd:NF041483  1142 RRESAEQMKSAGERCDAlvKAAEEQLAEAEAKAKELVSDANSEASKVRI-----AAVKKAEGLLKEAEQKKAELVREAEK 1216

                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2464 LQAimdEAVRkqkEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLrEQLQTFE 2518
Cdd:NF041483  1217 IKA---EAEA---EAKRTVEEGKRELDVLVRRREDINAEISRVQDVL-EALESFE 1264
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1270-1901 3.97e-30

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 131.98  E-value: 3.97e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1270 RLED--DEKAS--EKLKEEER--RKMAEIQAELDKQKQMAEAHAKSVAKAEQEALElkmkmkEEASKRQDVAADAEKQKQ 1343
Cdd:COG1196    190 RLEDilGELERqlEPLERQAEkaERYRELKEELKELEAELLLLKLRELEAELEELE------AELEELEAELEELEAELA 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1344 NIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIeeeihiiriqlekttahkaksEAELQELRDRAAEAEKLRKAAQDEA 1423
Cdd:COG1196    264 ELEAELEELR----LELEELELELEEAQAEEYEL---------------------LAELARLEQDIARLEERRRELEERL 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1424 ERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQkykmQAEEAERRMKQAEEEKIRQIRvveevAQKSAAT 1503
Cdd:COG1196    319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA----EAEEALLEAEAELAEAEEELE-----ELAEELL 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1504 QLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIwRQKANEALRLRLQAEEEAQKKS 1583
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE-AAEEEAELEEEEEALLELLAEL 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1584 HAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNEL 1663
Cdd:COG1196    469 LEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1664 QRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASmvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQ 1743
Cdd:COG1196    549 QNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAA----ALARGAIGAAVDLVASDLREADARYYVLGDTLLG 624

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1744 RQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKIT 1823
Cdd:COG1196    625 RTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEE 704

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1824 QLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINfhkASKEKADLESELKKLKGIADETQksklkAEEEAEKLKK 1901
Cdd:COG1196    705 EERELAEAEEERLEEELEEEALEEQLEAEREELLEEL---LEEEELLEEEALEELPEPPDLEE-----LERELERLER 774
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1428-2334 3.16e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.86  E-value: 3.16e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1428 KQVAEETQRK-KNAEDELKRKSDAEKEAAKQkqralddLQKYKMQAEEAER-RMKQAEEEKIR---QIRVVEEVAQKSAA 1502
Cdd:TIGR02168  171 KERRKETERKlERTRENLDRLEDILNELERQ-------LKSLERQAEKAERyKELKAELRELElalLVLRLEELREELEE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1503 TQLQTKAM-----SFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEE 1577
Cdd:TIGR02168  244 LQEELKEAeeeleELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1578 EaqkkshaQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRG 1657
Cdd:TIGR02168  324 Q-------LEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1658 LLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSL----LQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARM 1733
Cdd:TIGR02168  397 SLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAelkeLQAELEELEEELEELQEELERLEEALEELREELEEAEQA 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1734 RSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENerlKRQAEEEAYQRKLLEDQAAQ 1813
Cdd:TIGR02168  477 LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDE---GYEAAIEAALGGRLQAVVVE 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1814 HKQDIEEKITQLqtsSDSELGRQKNIVEETLKQKKVVEEEIHIIKiNFHKASKEKADLESELKKLKG----------IAD 1883
Cdd:TIGR02168  554 NLNAAKKAIAFL---KQNELGRVTFLPLDSIKGTEIQGNDREILK-NIEGFLGVAKDLVKFDPKLRKalsyllggvlVVD 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1884 ETQksklkaeeEAEKLKKLAAEEERRRKEAEEKVKR---ITAAEEEAARQCKAAQEEVERLKKKAEdankqkekaekeae 1960
Cdd:TIGR02168  630 DLD--------NALELAKKLRPGYRIVTLDGDLVRPggvITGGSAKTNSSILERRREIEELEEKIE-------------- 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1961 kqvvlakEAAQKCTAAEQKAQDVLSKnkedvlaQEKLRDEFENAKKLAQEaekakekaekeaalLRQKAEEAEKQKKAAE 2040
Cdd:TIGR02168  688 -------ELEEKIAELEKALAELRKE-------LEELEEELEQLRKELEE--------------LSRQISALRKDLARLE 739

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2041 NEAAKQAKAQNDTEKQRKEAEeeaarraaaeaaalKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQK 2120
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELE--------------AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2121 VLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEEnrrlmqkdkdstqklLAEEAEKMKSLAEEAGR 2200
Cdd:TIGR02168  806 DELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSED---------------IESLAAEIEELEELIEE 870

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2201 LSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQEtakRLQEDKQQIQQRLDKETE 2280
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLEL---RLEGLEVRIDNLQERLSE 947

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 2281 GFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTK-------AEDEAKKFKKQADEVKAQ 2334
Cdd:TIGR02168  948 EYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQ 1008
growth_prot_Scy NF041483
polarized growth protein Scy;
1407-2510 1.63e-25

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 117.23  E-value: 1.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1407 DRAAEAEKLRKAAQDEAERLRkqvaeetqrkKNAEDELkrksdaeKEAAKQKQRALDDL--QKYKMQAE---EAERRMKQ 1481
Cdd:NF041483    69 DIGYQAEQLLRNAQIQADQLR----------ADAEREL-------RDARAQTQRILQEHaeHQARLQAElhtEAVQRRQQ 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1482 AEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQ-----QKEANTAREEAEQ 1556
Cdd:NF041483   132 LDQELAERRQTVESHVNENVAWAEQLRARTESQARRLLDESRAEAEQALAAARAEAERLAEEarqrlGSEAESARAEAEA 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1557 eleIWRQKANEALRLRLQAEEEAQK-KSHAQ----------EEAEKQKLEAERDAKKRGKAEEAALKQkenAEKELDKQR 1625
Cdd:NF041483   212 ---ILRRARKDAERLLNAASTQAQEaTDHAEqlrsstaaesDQARRQAAELSRAAEQRMQEAEEALRE---ARAEAEKVV 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1626 KFAEQIAQQKLSAEQECirlkadfehAEQQRGLLDNELQRLKNE-VNSTEKQRKQLEDELNKVRSEMDSLLQMKinAEKA 1704
Cdd:NF041483   286 AEAKEAAAKQLASAESA---------NEQRTRTAKEEIARLVGEaTKEAEALKAEAEQALADARAEAEKLVAEA--AEKA 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1705 SMVNTEKS-----KQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKE-KLAAIN-------- 1770
Cdd:NF041483   355 RTVAAEDTaaqlaKAARTAEEVLTKASEDAKATTRAAAEEAERIRREAEAEADRLRGEAADQAEQlKGAAKDdtkeyrak 434

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1771 ------EATRLKTEAEMALKAKEAENERLKRQAEEEAYQR-----KLLEDQAAQHKQDIEEkiTQLQTSSDSELGRQKNI 1839
Cdd:NF041483   435 tvelqeEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQieeaaRTAEELLTKAKADADE--LRSTATAESERVRTEAI 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1840 ---------VEETLKQKKvVEEEIHIIKINfHKASKEKADLESELKKLKgiADETQKSKLKAEEEAEKLKKLAAEEErrr 1910
Cdd:NF041483   513 erattlrrqAEETLERTR-AEAERLRAEAE-EQAEEVRAAAERAARELR--EETERAIAARQAEAAEELTRLHTEAE--- 585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1911 keaeekvKRITAAEE-------EAARQCKAAQEEVERLkkKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDV 1983
Cdd:NF041483   586 -------ERLTAAEEaladaraEAERIRREAAEETERL--RTEAAERIRTLQAQAEQEAERLRTEAAADASAARAEGENV 656

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1984 LSKNKEDVLAQ-EKLRDEFENAKKlaqeaekakekaekeaallRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKeaee 2062
Cdd:NF041483   657 AVRLRSEAAAEaERLKSEAQESAD-------------------RVRAEAAAAAERVGTEAAEALAAAQEEAARRRR---- 713

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2063 eaarraaaeaaalkqkqQADAEMSKHKKEAEQALQQ-KSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQK 2141
Cdd:NF041483   714 -----------------EAEETLGSARAEADQERERaREQSEELLASARKRVEEAQAEAQRLVEEADRRATELVSAAEQT 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2142 SQ-VEVELARVRIQM-EELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEA-EETARQRQIAESN 2218
Cdd:NF041483   777 AQqVRDSVAGLQEQAeEEIAGLRSAAEHAAERTRTEAQEEADRVRSDAYAERERASEDANRLRREAqEETEAAKALAERT 856

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2219 LAEQRALAEKILKEK---------------MQAIQEATKLKAEA-EKLQKQKDQAQETAKRL------QEDKQQIQQRLD 2276
Cdd:NF041483   857 VSEAIAEAERLRSDAseyaqrvrteasdtlASAEQDAARTRADArEDANRIRSDAAAQADRLigeatsEAERLTAEARAE 936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2277 KETEGFQKSLEAERKR----------QLEASAEAEKLKLRVKE-LSLAQTKAE---DEAKKFKKQADEVKAQLQRTEKHT 2342
Cdd:NF041483   937 AERLRDEARAEAERVRadaaaqaeqlIAEATGEAERLRAEAAEtVGSAQQHAErirTEAERVKAEAAAEAERLRTEAREE 1016

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2343 TEIVVQklETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIE------QQKAELQQSFLTEKG 2416
Cdd:NF041483  1017 ADRTLD--EARKDANKRRSEAAEQADTLITEAAAEADQLTAKAQEEALRTTTEAEAQADtmvgaaRKEAERIVAEATVEG 1094

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2417 LLLkrekeVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAimdeavRKQKEAEEEMKNKQREMDVLDKKR 2496
Cdd:NF041483  1095 NSL-----VEKARTDADELLVGARRDATAIRERAEELRDRITGEIEELHE------RARRESAEQMKSAGERCDALVKAA 1163

                         1210
                   ....*....|....
gi 1389908296 2497 LEQEKQLAEENKKL 2510
Cdd:NF041483  1164 EEQLAEAEAKAKEL 1177
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1607-2534 3.00e-25

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 116.22  E-value: 3.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1607 EEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNK 1686
Cdd:pfam02463  172 KEALKKLIEETENLAELIIDLEELKLQELKLKEQA---KKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1687 VRSEMDSLLQmKINAEKASMvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKL 1766
Cdd:pfam02463  249 EQEEIESSKQ-EIEKEEEKL---AQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1767 AAINEATRLKTEAEMALKAKEaENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQ 1846
Cdd:pfam02463  325 KAEKELKKEKEEIEELEKELK-ELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1847 KKVVEEEIHIIKINFHKASKEKadlESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEE 1926
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEK---KEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLV 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1927 AARQCKaaQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLaqeKLRDEFENAKK 2006
Cdd:pfam02463  481 KLQEQL--ELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVA---ISTAVIVEVSA 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2007 LAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMS 2086
Cdd:pfam02463  556 TADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2087 KHKKEAeqalqqKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIE 2166
Cdd:pfam02463  636 KLKESA------KAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREK 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2167 EENRRLMQKDKDSTQKLLAEEAEKmkslaeeagrlsvEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAE 2246
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDK-------------INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKEL 776

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2247 AEKLQKQKDQAQETAKRLQEdkqqiqqrldketegfqKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKK 2326
Cdd:pfam02463  777 AEEREKTEKLKVEEEKEEKL-----------------KAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELA 839

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QaDEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAE 2406
Cdd:pfam02463  840 L-ELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENE 918

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2407 LQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQER-QRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNK 2485
Cdd:pfam02463  919 IEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRlLLAKEELGKVNLMAIEEFEEKEERYNKDELEKE 998

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*....
gi 1389908296 2486 QREMDVLDKKRLEQEkqlaEENKKLREQLQTFEISSKTVSQTKESQTVS 2534
Cdd:pfam02463  999 RLEEEKKKLIRAIIE----ETCQRLKEFLELFVSINKGWNKVFFYLELG 1043
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1671-2470 1.17e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 110.92  E-value: 1.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1671 NSTEKQRKQLEDELNKVRSEMDSLlqmKINAEKAsmvntEKSKQLleSEALKMKQLADEAARMRSvAEEAKKQRQIAEEE 1750
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSL---ERQAEKA-----ERYKEL--KAELRELELALLVLRLEE-LREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1751 AARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQtssd 1830
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE---- 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1831 sELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIAD---ETQKSKLKAEEEAE-----KLKKL 1902
Cdd:TIGR02168  327 -ELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEeqlETLRSKVAQLELQIaslnnEIERL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1903 AAEEERRRKEAEEKVKRITAAEEEAAR-QCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQ 1981
Cdd:TIGR02168  406 EARLERLEDRRERLQQEIEELLKKLEEaELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1982 DVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEkeaaLLRQKAEEAEKQKKAAE--------------NEAAKQA 2047
Cdd:TIGR02168  486 QLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILG----VLSELISVDEGYEAAIEaalggrlqavvvenLNAAKKA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2048 KA---QNDTEKQ-----RKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAE-----------------QALQQKSQV 2102
Cdd:TIGR02168  562 IAflkQNELGRVtflplDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvddldNALELAKKL 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2103 EKELTVVKLQLD-------------ETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEEL----VKLKLKI 2165
Cdd:TIGR02168  642 RPGYRIVTLDGDlvrpggvitggsaKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELeeelEQLRKEL 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2166 EEENRRLmqkdkDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKA 2245
Cdd:TIGR02168  722 EELSRQI-----SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2246 EAEKLQKQKDQAQETAKRLQEDKQQIQQRLD---KETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAK 2322
Cdd:TIGR02168  797 ELKALREALDELRAELTLLNEEAANLRERLEsleRRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2323 KFKKQADEVKAQLQ--RTEKHTTEIVVQKLETQRLQSTREADDLKSAIADleeerkklkkeaeelqrkskemANAQQEQI 2400
Cdd:TIGR02168  877 ALLNERASLEEALAllRSELEELSEELRELESKRSELRRELEELREKLAQ----------------------LELRLEGL 934

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2401 EQQKAELQQSFLTEKGLLL-----------KREKEVEGEKKRFEKQLE----------DEMKKAKALKDEQERQRKLMEE 2459
Cdd:TIGR02168  935 EVRIDNLQERLSEEYSLTLeeaealenkieDDEEEARRRLKRLENKIKelgpvnlaaiEEYEELKERYDFLTAQKEDLTE 1014

                          890
                   ....*....|.
gi 1389908296 2460 ERKKLQAIMDE 2470
Cdd:TIGR02168 1015 AKETLEEAIEE 1025
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1241-2107 1.47e-22

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 107.36  E-value: 1.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALEL 1320
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1321 -KMKMKEEASKRQDVAADAEKQKQN---------IQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEK 1390
Cdd:pfam02463  246 lRDEQEEIESSKQEIEKEEEKLAQVlkenkeeekEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1391 TTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQ----RALDDLQ 1466
Cdd:pfam02463  326 AEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEeeleLKSEEEK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKE 1546
Cdd:pfam02463  406 EAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQ 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1547 ANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRK 1626
Cdd:pfam02463  486 LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQK 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1627 FAEQIAQQKLSAEQECIRLKADFE----HAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAE 1702
Cdd:pfam02463  566 LVRALTELPLGARKLRLLIPKLKLplksIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKE 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1703 KASMVNTEKSKQLLESEALKMKQLADeaaRMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEma 1782
Cdd:pfam02463  646 SGLRKGVSLEEGLAEKSEVKASLSEL---TKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAE-- 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1783 lkakEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGR---QKNIVEETLKQKKVVEEEIHIIKI 1859
Cdd:pfam02463  721 ----ELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELslkEKELAEEREKTEKLKVEEEKEEKL 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1860 NFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVE 1939
Cdd:pfam02463  797 KAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1940 RLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQ----KAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAK 2015
Cdd:pfam02463  877 EELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKeneiEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKE 956

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2016 EKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADA---EMSKHKKEA 2092
Cdd:pfam02463  957 EEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLElfvSINKGWNKV 1036

                          890
                   ....*....|....*
gi 1389908296 2093 EQALQQKSQVEKELT 2107
Cdd:pfam02463 1037 FFYLELGGSAELRLE 1051
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1871-2470 3.55e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 3.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1871 LESELKKLKGIADETQKSK-LKAEE---EAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAE 1946
Cdd:COG1196    198 LERQLEPLERQAEKAERYReLKEELkelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELE 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1947 DANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLR 2026
Cdd:COG1196    278 ELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2027 QKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKEL 2106
Cdd:COG1196    358 AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2107 TVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDST-QKLLA 2185
Cdd:COG1196    438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKaALLLA 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2186 EEAEKMKSLAEEAGRLSVE--AEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLkaEAEKLQKQKDQAQETAKR 2263
Cdd:COG1196    518 GLRGLAGAVAVLIGVEAAYeaALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFL--PLDKIRARAALAAALARG 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2264 LQEDKQQIQQRLDKETEGFQKSLEA-------ERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQ 2336
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDtllgrtlVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2337 RTEKHTTEIVVQKL-ETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEK 2415
Cdd:COG1196    676 EAEAELEELAERLAeEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEE 755

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2416 GLLLKREKEVEGEKKRFEKQLE----------DEMKKAKALKDEQERQRKLMEEERKKLQAIMDE 2470
Cdd:COG1196    756 LPEPPDLEELERELERLEREIEalgpvnllaiEEYEELEERYDFLSEQREDLEEARETLEEAIEE 820
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 713-779 7.12e-21

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 88.86  E-value: 7.12e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  713 QLKPRNptTPLKGKMPIQAVCDFKQMEITVHRGDECALLNNSNPFKWQVLNDTGSEASVPSICFLVP 779
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
growth_prot_Scy NF041483
polarized growth protein Scy;
1520-2481 1.45e-17

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 91.04  E-value: 1.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALR------------LRLQAEeeaQKKSHAQE 1587
Cdd:NF041483     7 QESHRADDDHLSRFEAEMDRLKTEREKAVQHAEDLGYQVEVLRAKLHEARRslasrpaydgadIGYQAE---QLLRNAQI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1588 EAEKQKLEAERdakkrgkaeeaalkqkenaekELDKQRKFAEQIAQqklsaeqecirlkadfEHAEQQrglldnelQRLK 1667
Cdd:NF041483    84 QADQLRADAER---------------------ELRDARAQTQRILQ----------------EHAEHQ--------ARLQ 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1668 NEVNSTEKQRKQ-LEDELNKVRSEMDSLLQMKIN-AEKASMVNTEKSKQLL-ESEALKMKQLADEAARMRSVAEEAKkQR 1744
Cdd:NF041483   119 AELHTEAVQRRQqLDQELAERRQTVESHVNENVAwAEQLRARTESQARRLLdESRAEAEQALAAARAEAERLAEEAR-QR 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1745 QIAEEEAARqrSEAEKILK------EKL--AAINEATRLKTEAEMALKAKEAENERLKRQAEEeayqrklLEDQAAQHKQ 1816
Cdd:NF041483   198 LGSEAESAR--AEAEAILRrarkdaERLlnAASTQAQEATDHAEQLRSSTAAESDQARRQAAE-------LSRAAEQRMQ 268

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1817 DIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEihiikiNFHKASKEKADLESE-LKKLKGIADETQKSKLKAEEE 1895
Cdd:NF041483   269 EAEEALREARAEAEKVVAEAKEAAAKQLASAESANEQ------RTRTAKEEIARLVGEaTKEAEALKAEAEQALADARAE 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1896 AEKLkklaaeeerrrKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAekeaekqvvlAKEAAQKCTA 1975
Cdd:NF041483   343 AEKL-----------VAEAAEKARTVAAEDTAAQLAKAARTAEEVLTKASEDAKATTRAA----------AEEAERIRRE 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1976 AEQKAqDVLSKNKEDVLAQEK---LRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQND 2052
Cdd:NF041483   402 AEAEA-DRLRGEAADQAEQLKgaaKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQIEEAAR 480

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2053 TEKQrkeaeeeaarraaaeaaaLKQKQQADAEMSKHKKEAEQALQQKSQVEKElTVVKLQLDETdkqkvlldqeLQRVKG 2132
Cdd:NF041483   481 TAEE------------------LLTKAKADADELRSTATAESERVRTEAIERA-TTLRRQAEET----------LERTRA 531

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2133 EvndAFKQKSQVEVELARVRIQMEELVKlklKIEEENRRLMQkdkdstqkllAEEAEKmkslAEEAGRLSVEAEEtarQR 2212
Cdd:NF041483   532 E---AERLRAEAEEQAEEVRAAAERAAR---ELREETERAIA----------ARQAEA----AEELTRLHTEAEE---RL 588

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2213 QIAESNLAEQRALAEKILKEkmqAIQEATKLKAEA-EKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFqksleAERK 2291
Cdd:NF041483   589 TAAEEALADARAEAERIRRE---AAEETERLRTEAaERIRTLQAQAEQEAERLRTEAAADASAARAEGENV-----AVRL 660

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2292 RQlEASAEAEKLKLRVKEL-----SLAQTKAE---DEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADD 2363
Cdd:NF041483   661 RS-EAAAEAERLKSEAQESadrvrAEAAAAAErvgTEAAEALAAAQEEAARRRREAEETLGSARAEADQERERAREQSEE 739

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2364 -LKSAIADLEEERKKLKKEAEELQRKSKEMANAqQEQIEQQKAElqqsflTEKGLLLKREKEVEGEKKRFEKQLEDEMKK 2442
Cdd:NF041483   740 lLASARKRVEEAQAEAQRLVEEADRRATELVSA-AEQTAQQVRD------SVAGLQEQAEEEIAGLRSAAEHAAERTRTE 812

                          970       980       990
                   ....*....|....*....|....*....|....*....
gi 1389908296 2443 AkalKDEQERQRKLMEEERKKLQaimDEAVRKQKEAEEE 2481
Cdd:NF041483   813 A---QEEADRVRSDAYAERERAS---EDANRLRREAQEE 845
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3961-3999 4.19e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 71.59  E-value: 4.19e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3961 LLEAQIATGGIIDPQESHRLPVETAYERGLFDEEMNEIL 3999
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 537-727 1.83e-14

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 75.56  E-value: 1.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  537 QLHAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAF 616
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  617 TAALQTQWSWLLQLCCCIETHLKENTAHFQFFTDVKEAEEKLKKMQDTMKRKYTCDrsiTVTRLEDLLQDAADEKEQLAE 696
Cdd:cd00176     81 LEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGK---DLESVEELLKKHKELEEELEA 157

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1389908296  697 FKTNLEALKRRAKTVIQLKPRNPTTPLKGKM 727
Cdd:cd00176    158 HEPRLKSLNELAEELLEEGHPDADEEIEEKL 188
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2978-3016 2.67e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.28  E-value: 2.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2978 FLEAQAATGFVIDPIKNERVPVDEAVKSGLVGPEIHERL 3016
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3642-3680 1.98e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 66.97  E-value: 1.98e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3642 LLEAQAATGFMIDPVKDELLTVDEAVRKGLVGPELHDKL 3680
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3385-3421 6.50e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 65.43  E-value: 6.50e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1389908296 3385 LLEAQLATGGIIDPASSHRVPTDVAIQRGYFSKQMAK 3421
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3309-3347 1.38e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.66  E-value: 1.38e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3309 LLEAQAATGFITDPVKDKKCSVDDAVKEGIVGPELHEKL 3347
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2652-2690 1.74e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.27  E-value: 1.74e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2652 LLEAQAASGFIVDPVKNKFLSVDEAVKDKVIGPELHDRL 2690
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4231-4269 4.24e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.12  E-value: 4.24e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 4231 LLEAQACTGGIIDPNTGEKFSVVDAMNKGLVDKIMVDRI 4269
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2728-2766 1.41e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 61.57  E-value: 1.41e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2728 FLDVQLATGGIIDPVNSHRVPLQTAYSQGQFDADMNKKL 2766
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3718-3756 1.48e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 61.57  E-value: 1.48e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3718 LLEAQNATGGYMDPEYYFRLPIDVAMQRGYINKETHERL 3756
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3054-3092 6.66e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 59.65  E-value: 6.66e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3054 LLEAQLSTGGIVDPVKSYRIPHEVACKRGYFDDKMSKTL 3092
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
4229-4266 1.44e-10

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 58.65  E-value: 1.44e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4229 QRLLEAQACTGGIIDPNTGEKFSVVDAMNKGLVDKIMV 4266
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3885-3923 1.97e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 58.49  E-value: 1.97e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3885 LLEAQAATGYVIDPIKNLKLNVTEAVKMGIVGTEFKDKL 3923
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 442-631 2.49e-10

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 63.23  E-value: 2.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  442 LRYTQDLLGWVEENQRRVDEGEWGSDLPTVESLLGSHRGLHQCVEEFRSKIERAKADESQV---SPASKAAYRDYLGKLE 518
Cdd:cd00176      6 LRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLieeGHPDAEEIQERLEELN 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  519 LQYGKLLTSSKARLRYLD---QLHAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAV 595
Cdd:cd00176     86 QRWEELRELAEERRQRLEealDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSL 165

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1389908296  596 QTTGDKLLRDGHP-ARKTIEAFTAALQTQWSWLLQLC 631
Cdd:cd00176    166 NELAEELLEEGHPdADEEIEEKLEELNERWEELLELA 202
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1388-1809 1.42e-09

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 64.26  E-value: 1.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1388 LEKTTAHKAKSEAELqelrdraaeAEKLRKAAQDEAERLRKQVAEETqrKKNAEDElKRKSDAEKEAAKQKQralDDLQK 1467
Cdd:NF033838   101 LYELNVLKEKSEAEL---------TSKTKKELDAAFEQFKKDTLEPG--KKVAEAT-KKVEEAEKKAKDQKE---EDRRN 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1468 Y--------KMQAEEAERRMKQAEEEkirqirVVEEVAQKSaatqlqtkamsfseqttKLEESLKKEQGNVLKLQEEADK 1539
Cdd:NF033838   166 YptntyktlELEIAESDVEVKKAELE------LVKEEAKEP-----------------RDEEKIKQAKAKVESKKAEATR 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1540 LKKQQkeanTAREEAEQeleiwrqkanEALRLRLQAEEEAQKKSHAQEEAEKQKleaeRDAKKRGKAEEAALKQKENAEK 1619
Cdd:NF033838   223 LEKIK----TDREKAEE----------EAKRRADAKLKEAVEKNVATSEQDKPK----RRAKRGVLGEPATPDKKENDAK 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1620 ELDKQRKfAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRlknevNSTEKQRKQLEDELNKVRSEMDSLLQMKI 1699
Cdd:NF033838   285 SSDSSVG-EETLPSPSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRR-----NYPTNTYKTLELEIAESDVKVKEAELELV 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1700 NAEKASMVNTEKSKQLLESEALKMKqladEAARMrsvaEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEA 1779
Cdd:NF033838   359 KEEAKEPRNEEKIKQAKAKVESKKA----EATRL----EKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEK 430

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1389908296 1780 EMALKAKEAENERLKR---QAEEEAYQRKLLED 1809
Cdd:NF033838   431 PAPKPEKPAEQPKAEKpadQQAEEDYARRSEEE 463
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 111-173 6.51e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 56.53  E-value: 6.51e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296  111 PALIDMNQVYRQSNQ--ENLEQAFSVAERELGVTK-LLDPEDVDvpHPDEKSIITYVSSLYDVMPR 173
Cdd:pfam00307   46 PGLVDKKKLNKSEFDklENINLALDVAEKKLGVPKvLIEPEDLV--EGDNKSVLTYLASLFRRFQA 109
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4307-4345 6.86e-09

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 53.87  E-value: 6.86e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 4307 FLEVQYLTGGLIEPDATNRVAIDEAVKKGTLDARTAQKL 4345
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3959-3995 4.49e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 51.71  E-value: 4.49e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3959 IRLLEAQIATGGIIDPQESHRLPVETAYERGLFDEEM 3995
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4062-4090 4.95e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.86  E-value: 4.95e-07
                           10        20
                   ....*....|....*....|....*....
gi 1389908296 4062 IVDPESGKEMSVYEAYQKGLIDHQTYLEL 4090
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
539-631 5.11e-07

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 50.79  E-value: 5.11e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296   539 HAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAFTA 618
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLE 80

                            90
                    ....*....|...
gi 1389908296   619 ALQTQWSWLLQLC 631
Cdd:smart00150   81 ELNERWEELKELA 93
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1251-1534 6.14e-07

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 56.38  E-value: 6.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1251 SELMTLTNQYIKFIID---AQRRLEDDEKA---SEKLKEEERRKMAEI---QAEL---DKQKQMAEAHAKSVA-KAEQEA 1317
Cdd:NF012221  1538 SESSQQADAVSKHAKQddaAQNALADKERAeadRQRLEQEKQQQLAAIsgsQSQLestDQNALETNGQAQRDAiLEESRA 1617

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1318 L--ELKMKMKE-EASKRQDVAAD----------AEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIeeeihii 1384
Cdd:NF012221  1618 VtkELTTLAQGlDALDSQATYAGesgdqwrnpfAGGLLDRVQEQLDDAKKISGKQLADAKQRHVDNQQKVKDA------- 1690

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1385 riqLEKTTAHKAKSEAELQELRDRAAEAEKlrKAAQDEAERLRKQvaeetQRKKNAEdelkrkSDAEKEAAKQKQRALDD 1464
Cdd:NF012221  1691 ---VAKSEAGVAQGEQNQANAEQDIDDAKA--DAEKRKDDALAKQ-----NEAQQAE------SDANAAANDAQSRGEQD 1754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1465 LQKYKMQAEEAE---RRMKQAEEEKIRQIRV-----------VEEVAQKSAA--TQLQTKAMS-FSEQTTKLE-ESLKKE 1526
Cdd:NF012221  1755 ASAAENKANQAQadaKGAKQDESDKPNRQGAagsglsgkaysVEGVAEPGSHinPDSPAAADGrFSEGLTEQEqEALEGA 1834


                   ....*...
gi 1389908296 1527 QGNVLKLQ 1534
Cdd:NF012221  1835 TNAVNRLQ 1842
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2164-2513 7.32e-07

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 55.79  E-value: 7.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2164 KIEEENRRLMQKDKDSTQKLLAEEAEKMKSlaeEAGRLSVEAEETARQRQIAESNlAEQRALAEKILKEKMQ---AIQEA 2240
Cdd:NF033838    69 KILSEIQKSLDKRKHTQNVALNKKLSDIKT---EYLYELNVLKEKSEAELTSKTK-KELDAAFEQFKKDTLEpgkKVAEA 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2241 TKLKAEAEKlqKQKDQAQEtakrlqedkqqiqQRLDKETEGFqKSLEAERkrqleasAEAEkLKLRVKELSLAQTKAEDE 2320
Cdd:NF033838   145 TKKVEEAEK--KAKDQKEE-------------DRRNYPTNTY-KTLELEI-------AESD-VEVKKAELELVKEEAKEP 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2321 AKKFKKQADEVKAQLQRTEKHTTEivvqKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQ--E 2398
Cdd:NF033838   201 RDEEKIKQAKAKVESKKAEATRLE----KIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPatP 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2399 QIEQQKAELQQSFLTEKGL---LLKREKEV-EGEKKRFEKQledemKKAKALKDEQERQ-----RKLMEEE--------- 2460
Cdd:NF033838   277 DKKENDAKSSDSSVGEETLpspSLKPEKKVaEAEKKVEEAK-----KKAKDQKEEDRRNyptntYKTLELEiaesdvkvk 351

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2461 RKKLQAIMDEAVR-----KQKEAEEEMKNKQREMDVLD------KKRLEQEKQLAEENKKLREQ 2513
Cdd:NF033838   352 EAELELVKEEAKEprneeKIKQAKAKVESKKAEATRLEkiktdrKKAEEEAKRKAAEEDKVKEK 415
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1474-1853 5.13e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 53.30  E-value: 5.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 EAERRMKQAEEEKIRQI---RVVEEVAQKSAATQLQTKAMSFSEQTTKLE-------ESLKKEQGNVL---KLQEEADKL 1540
Cdd:NF012221  1468 DFARRAGLSTNNGIEVLwngEVVFASSGDASAWQQKTLKLTAKAGSNRLEfkgtghnDGLGYILDNVVatsESSQQADAV 1547

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1541 KKQQKEaNTAREEAEQEleiwrQKANEALRLRLQAEEEAQ----KKSHAQEEA-EKQKLEaerdakKRGKAEEAALKQKE 1615
Cdd:NF012221  1548 SKHAKQ-DDAAQNALAD-----KERAEADRQRLEQEKQQQlaaiSGSQSQLEStDQNALE------TNGQAQRDAILEES 1615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1616 NA-EKELDKQRKFAEQIAQQKLSAEQECIRLKADFehAEqqrGLLDNelqrlknevnstekqrkqledelnkVRSEMDsl 1694
Cdd:NF012221  1616 RAvTKELTTLAQGLDALDSQATYAGESGDQWRNPF--AG---GLLDR-------------------------VQEQLD-- 1663

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1695 lqmkiNAEKASMVNTEKSKQLLESEALKMKqlaDEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATR 1774
Cdd:NF012221  1664 -----DAKKISGKQLADAKQRHVDNQQKVK---DAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQ 1735

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1775 LKTEAEMALKAKEAENERLKRQAEEEAYQrklLEDQAAQHKQDIEEKITQlQTSSDSELGRQKNIVEETLKQKKVVEEE 1853
Cdd:NF012221  1736 AESDANAAANDAQSRGEQDASAAENKANQ---AQADAKGAKQDESDKPNR-QGAAGSGLSGKAYSVEGVAEPGSHINPD 1810
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 110-167 9.97e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 46.93  E-value: 9.97e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296   110 VPALIDMNQVYRQSNQ----ENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSL 167
Cdd:smart00033   40 SPGLVDKKKVAASLSRfkkiENINLALSFAEKLGGKVVLFEPEDLVEGPKLILGVIWTLISL 101
PLEC smart00250
Plectin repeat;
2689-2725 1.08e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 1.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2689 RLLSAERAATGFKDPYTGAKISLFEAMNKGLIEKEQA 2725
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3015-3051 1.12e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 1.12e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3015 RLLSAEKAVSGYHDPYTGKKVSLFEALKLGLIKKDHG 3051
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3847-3885 1.19e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 45.01  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3847 YLEGSSCIAGVYVESSKDRLSIYQAMKKNMIRPGTAFEL 3885
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3845-3882 2.11e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  3845 KKYLEGSSCIAGVYVESSKDRLSIYQAMKKNMIRPGTA 3882
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3385-3420 2.35e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.35e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1389908296  3385 LLEAQLATGGIIDPASSHRVPTDVAIQRGYFSKQMA 3420
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3346-3382 2.62e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.62e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3346 KLLSAEKAITGYRDPYTGNKISLFQAMKKELVLREHA 3382
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1387-1616 2.73e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 50.99  E-value: 2.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRA-AEAEKLRkaAQDEAERLRKQVAEeTQRKKNAEDE--LKRKSDAEKEAAKQKQRA-- 1461
Cdd:NF012221  1543 QADAVSKHAKQDDAAQNALADKErAEADRQR--LEQEKQQQLAAISG-SQSQLESTDQnaLETNGQAQRDAILEESRAvt 1619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1462 ---------LDDLQKYKMQAEEAERRMKQAEEEKIRQiRVVEEV--AQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNV 1530
Cdd:NF012221  1620 kelttlaqgLDALDSQATYAGESGDQWRNPFAGGLLD-RVQEQLddAKKISGKQLADAKQRHVDNQQKVKDAVAKSEAGV 1698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1531 LKLQEeadklKKQQKEANTAREEAEQEleiwrQKANEALRlrlqAEEEAQK-KSHAQEEAEKQKLEAERDAKKRG----- 1604
Cdd:NF012221  1699 AQGEQ-----NQANAEQDIDDAKADAE-----KRKDDALA----KQNEAQQaESDANAAANDAQSRGEQDASAAEnkanq 1764

                          250
                   ....*....|...
gi 1389908296 1605 -KAEEAALKQKEN 1616
Cdd:NF012221  1765 aQADAKGAKQDES 1777
PLEC smart00250
Plectin repeat;
4055-4083 2.87e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 2.87e-05
                            10        20
                    ....*....|....*....|....*....
gi 1389908296  4055 VRKRRVVIVDPESGKEMSVYEAYQKGLID 4083
Cdd:smart00250    6 AQSAIGGIIDPETGQKLSVEEALRRGLID 34
PLEC smart00250
Plectin repeat;
2976-3012 4.46e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 4.46e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2976 LNFLEAQAATGFVIDPIKNERVPVDEAVKSGLVGPEI 3012
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
SAC6 COG5069
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];
110-168 9.40e-05

Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];


Pssm-ID: 227401 [Multi-domain]  Cd Length: 612  Bit Score: 48.78  E-value: 9.40e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  110 VPALIDMNQVYRQSNQE--NLEQAFSVAERELGVTKLLDPEDV-DVPHPDEKSIITYVSSLY 168
Cdd:COG5069    168 RPDTLDPNVLDLQKKNKalNNFQAFENANKVIGIARLIGVEDIvNVSIPDERSIMTYVSWYI 229
PLEC smart00250
Plectin repeat;
4195-4228 1.08e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  4195 EETGPIAGILDTDTLEKVSVTEAIHRNLVDNITG 4228
Cdd:smart00250    5 EAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2941-2976 2.17e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 41.16  E-value: 2.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1389908296 2941 LQGTPSIAGILDEPTKEKMPFYQAMKKEFLSPETAL 2976
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
PLEC smart00250
Plectin repeat;
3642-3675 2.19e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.31  E-value: 2.19e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  3642 LLEAQAATGFMIDPVKDELLTVDEAVRKGLVGPE 3675
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 2433-2515 2.19e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 46.42  E-value: 2.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2433 EKQLEDEMKKAKALkdeqERQRKLMEEERKKLQAIMDEAVRKQKEA--------EEEMKNKQREMD-VLDKKRLEQEKQL 2503
Cdd:cd16269    197 EKEIEAERAKAEAA----EQERKLLEEQQRELEQKLEDQERSYEEHlrqlkekmEEERENLLKEQErALESKLKEQEALL 272

                           90
                   ....*....|..
gi 1389908296 2504 AEENKKLREQLQ 2515
Cdd:cd16269    273 EEGFKEQAELLQ 284
PLEC smart00250
Plectin repeat;
2652-2685 2.53e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 2.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  2652 LLEAQAASGFIVDPVKNKFLSVDEAVKDKVIGPE 2685
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
3716-3752 2.97e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 2.97e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3716 LRLLEAQNATGGYMDPEYYFRLPIDVAMQRGYINKET 3752
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PLEC smart00250
Plectin repeat;
3309-3342 3.06e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 3.06e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  3309 LLEAQAATGFITDPVKDKKCSVDDAVKEGIVGPE 3342
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 2034-2300 3.65e-04

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 47.14  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2034 KQKKAAENEAAKQAKAQNDteKQRkeaeeeaarraaaeaaaLKQ-KQQADAEMSKHKKEAE----QALQQKSQVEKEltV 2108
Cdd:NF012221  1552 KQDDAAQNALADKERAEAD--RQR-----------------LEQeKQQQLAAISGSQSQLEstdqNALETNGQAQRD--A 1610

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2109 VKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELA---RVRIQmEELVKLKLKIEEENRRLMQKDKDSTQKLla 2185
Cdd:NF012221  1611 ILEESRAVTKELTTLAQGLDALDSQATYAGESGDQWRNPFAgglLDRVQ-EQLDDAKKISGKQLADAKQRHVDNQQKV-- 1687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2186 eeaekMKSLAE-EAGrlsveAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLK----AEAEKLQKQKDQAQET 2260
Cdd:NF012221  1688 -----KDAVAKsEAG-----VAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAEsdanAAANDAQSRGEQDASA 1757

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1389908296 2261 AK----RLQEDKQQIQQRLDK--ETEGFQKSLEAERKRQLEASAEA 2300
Cdd:NF012221  1758 AEnkanQAQADAKGAKQDESDkpNRQGAAGSGLSGKAYSVEGVAEP 1803
PLEC smart00250
Plectin repeat;
2941-2975 4.57e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.54  E-value: 4.57e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1389908296  2941 LQGTPSIAGILDEPTKEKMPFYQAMKKEFLSPETA 2975
Cdd:smart00250    4 LEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2726-2762 4.85e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 4.85e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2726 TKFLDVQLATGGIIDPVNSHRVPLQTAYSQGQFDADM 2762
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 1395-1467 1.01e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 42.04  E-value: 1.01e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1395 KAKSEAELQELRdraAEAEKLRKAAQDEAERLRKQVAEETQRKKNaedelKRKSDAEKEAAKQKQRALDDLQK 1467
Cdd:cd06503     53 LAEYEEKLAEAR---AEAQEIIEEARKEAEKIKEEILAEAKEEAE-----RILEQAKAEIEQEKEKALAELRK 117
Spectrin pfam00435
Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in ...
 551-631 1.98e-03

Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteriztic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in multiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.


Pssm-ID: 395348 [Multi-domain]  Cd Length: 105  Bit Score: 40.76  E-value: 1.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  551 WLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAFTAALQTQWSWLLQL 630
Cdd:pfam00435   16 WIEEKEALLSSEDYGKDLESVQALLKKHKALEAELAAHQDRVEALNELAEKLIDEGHYASEEIQERLEELNERWEQLLEL 95


                   .
gi 1389908296  631 C 631
Cdd:pfam00435   96 A 96
PLEC smart00250
Plectin repeat;
4305-4342 2.46e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.23  E-value: 2.46e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4305 QRFLEVQYLTGGLIEPDATNRVAIDEAVKKGTLDARTA 4342
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4200-4231 3.00e-03

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 38.08  E-value: 3.00e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1389908296 4200 IAGILDTDTLEKVSVTEAIHRNLVDNITGQRL 4231
Cdd:pfam00681    8 TGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3922-3953 5.51e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 5.51e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1389908296  3922 KLVSAERAVTGYKDPYSGKVISLFQAMKKGLI 3953
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
PRK01156 PRK01156
chromosome segregation protein; Provisional
 990-1467 8.04e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.58  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  990 LRSELDLTLKKMEQVYGLSSVYLDKLKTVDVVIRNTADAEETLKNYEARLRDV-SKVPSEQKEVEKHRS-QMKSMRSEAE 1067
Cdd:PRK01156   209 DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAeSDLSMELEKNNYYKElEERHMKIIND 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1068 ADQVMFDRLQDDLRKATTVHDKmTRIHSERDADLEHYRQLVNGL---------LERWQAVFAQIELRLRELDLLGRHMNS 1138
Cdd:PRK01156   289 PVYKNRNYINDYFKYKNDIENK-KQILSNIDAEINKYHAIIKKLsvlqkdyndYIKKKSRYDDLNNQILELEGYEMDYNS 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1139 YRDSYEWLIRWLTEARQRQEKIQAvPISDSRALREQLTDE-KKLLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYK 1217
Cdd:PRK01156   368 YLKSIESLKKKIEEYSKNIERMSA-FISEILKIQEIDPDAiKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNM 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1218 A-LQDPIASPLKKPKM-ECASDDIIQEYVNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEK--ASEKLKE--EERRKMAE 1291
Cdd:PRK01156   447 EmLNGQSVCPVCGTTLgEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEylESEEINKsiNEYNKIES 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1292 IQAEL----DKQKQMAEAHAKSVAKAEQ------EALELK-------------------MKMKEEASKRQDvaaDAEKQK 1342
Cdd:PRK01156   527 ARADLedikIKINELKDKHDKYEEIKNRykslklEDLDSKrtswlnalavislidietnRSRSNEIKKQLN---DLESRL 603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSLSDQEIKSKNQQLeDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEA---------- 1412
Cdd:PRK01156   604 QEIEIGFPDDKSYIDKSIREIENEA-NNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEItsrindiedn 682

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1413 -EKLRKAAQD-EAERLRKQVAEETQRKKNAEDElKRKSDAEK--EAAKQKQRALDDLQK 1467
Cdd:PRK01156   683 lKKSRKALDDaKANRARLESTIEILRTRINELS-DRINDINEtlESMKKIKKAIGDLKR 740
PLEC smart00250
Plectin repeat;
4343-4380 9.19e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 36.69  E-value: 9.19e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4343 QKLRDVSAYSKYLTCPKTKLKISYKDAMERSMTEEGTG 4380
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 815-891 1.16e-39

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 142.74  E-value: 1.16e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  815 SWQYLMRDIHIIKTWNISMFKTLRVEEYRLALRNLEQHYQDFLRDSQDSQMFGAEDRMQVESNYNKANQHYNTMVTS 891
Cdd:pfam18373    2 SWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
PTZ00121 PTZ00121
MAEBL; Provisional
 1244-2057 1.17e-35

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 151.06  E-value: 1.17e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1244 VNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKE-EERRKMAEIQAELDKQKQMAEAHAKSVAKAEqealelkm 1322
Cdd:PTZ00121  1060 AEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKaEEAKKTETGKAEEARKAEEAKKKAEDARKAE-------- 1131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1323 kmkeEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAEL 1402
Cdd:PTZ00121  1132 ----EARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARK 1207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1403 QELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQA 1482
Cdd:PTZ00121  1208 AEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE 1287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1483 EEEKIRQIRVVEEVAQksaATQLQTKAmsfsEQTTKLEESLKKEQgnvlKLQEEADKLKKQQKEANTAREEAEQELEiwr 1562
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKK---ADEAKKKA----EEAKKADEAKKKAE----EAKKKADAAKKKAEEAKKAAEAAKAEAE--- 1353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1563 QKANEALRLRLQAEEEAQKKSHAQEEAEkqklEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEC 1642
Cdd:PTZ00121  1354 AAADEAEAAEEKAEAAEKKKEEAKKKAD----AAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1643 IRlKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLE-----DELNKVRSEMDSLLQMKINAEKASmvntEKSKQLLE 1717
Cdd:PTZ00121  1430 KK-KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEeakkaDEAKKKAEEAKKADEAKKKAEEAK----KKADEAKK 1504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1718 SEALKMKqlADEAARmrsvAEEAKKQRQIAEEEAARQRSEAEKILKEKLA-AINEATRLKT-----EAEMALKAKEAENE 1791
Cdd:PTZ00121  1505 AAEAKKK--ADEAKK----AEEAKKADEAKKAEEAKKADEAKKAEEKKKAdELKKAEELKKaeekkKAEEAKKAEEDKNM 1578

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1792 RLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDS-----ELGRQKNIVEETLKQKKVVEEEIHiiKINFHKASK 1866
Cdd:PTZ00121  1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAkikaeELKKAEEEKKKVEQLKKKEAEEKK--KAEELKKAE 1656

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1867 EKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEE----VERLK 1942
Cdd:PTZ00121  1657 EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEnkikAEEAK 1736

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1943 KKAEDANKQKEKAEKEAEKqvvlaKEAAQKCTAAEQKAQDVLSKNKEDVLAQE--------------KLRDEFENAKKL- 2007
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEE-----KKKIAHLKKEEEKKAEEIRKEKEAVIEEEldeedekrrmevdkKIKDIFDNFANIi 1811

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2008 -------------AQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQR 2057
Cdd:PTZ00121  1812 eggkegnlvindsKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEK 1874
CH_PLEC-like_rpt2 cd21189
second calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family ...
 111-172 8.21e-35

second calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family includes plectin, dystonin and microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1). Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It could also bind muscle proteins such as actin to membrane complexes in muscle. Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409038  Cd Length: 105  Bit Score: 130.20  E-value: 8.21e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21189     44 PDLIDFRSVRNQSNRENLENAFNVAEKEFGVTRLLDPEDVDVPEPDEKSIITYVSSLYDVFP 105
PTZ00121 PTZ00121
MAEBL; Provisional
 1411-2327 1.13e-34

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 147.98  E-value: 1.13e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1411 EAEKLRKAAQDEAERLRKQVAEETQRKKNAEDElkrksdAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEekirqI 1490
Cdd:PTZ00121  1059 KAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADE------ATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAED-----A 1127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1491 RVVEEVAQksaatqlqtkamsfSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQ--KEANTAR--EEAEQELEIwrQKAN 1566
Cdd:PTZ00121  1128 RKAEEARK--------------AEDARKAEEARKAEDAKRVEIARKAEDARKAEeaRKAEDAKkaEAARKAEEV--RKAE 1191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1567 EalrlrLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEaaLKQKENAEKELDKQRKfaeqiAQQKLSAEQECIRLK 1646
Cdd:PTZ00121  1192 E-----LRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEA--VKKAEEAKKDAEEAKK-----AEEERNNEEIRKFEE 1259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1647 ADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQleDELNKVRsEMDSLLQMKINAEKASMVNTEKSKqlleseALKMKQL 1726
Cdd:PTZ00121  1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKA--DEAKKAE-EKKKADEAKKKAEEAKKADEAKKK------AEEAKKK 1330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1727 ADEAARMrsvAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAEN--ERLKRQAEEEAYQR 1804
Cdd:PTZ00121  1331 ADAAKKK---AEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKkaDEAKKKAEEDKKKA 1407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1805 KLLEDQAAQHKQDIEEKITQLQTSSDSELgrqkniveetlkqKKVVEEeihiikinfhkasKEKADlesELKKLKGIADE 1884
Cdd:PTZ00121  1408 DELKKAAAAKKKADEAKKKAEEKKKADEA-------------KKKAEE-------------AKKAD---EAKKKAEEAKK 1458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1885 TQKSKLKAEE--EAEKLKKlaaeeerrrkeaeekvkritaaEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQ 1962
Cdd:PTZ00121  1459 AEEAKKKAEEakKADEAKK----------------------KAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAK 1516

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1963 VVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENE 2042
Cdd:PTZ00121  1517 KAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2043 AAKQAkaqnDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQkvl 2122
Cdd:PTZ00121  1597 VMKLY----EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK--- 1669

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2123 lDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLaeEAEKMKSLAEEAGRLS 2202
Cdd:PTZ00121  1670 -AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKI--KAEEAKKEAEEDKKKA 1746

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2203 VEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKlkaeaEKLQKQKDQAQETAKRLQEDKQQIQqrldketegf 2282
Cdd:PTZ00121  1747 EEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELD-----EEDEKRRMEVDKKIKDIFDNFANII---------- 1811

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 1389908296 2283 qkslEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQ 2327
Cdd:PTZ00121  1812 ----EGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKH 1852
PTZ00121 PTZ00121
MAEBL; Provisional
 1458-2442 3.36e-34

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 146.44  E-value: 3.36e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1458 KQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTkamsFSEQTTKLEESLKKEQGNVlklqEEA 1537
Cdd:PTZ00121  1043 KEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEA----TEEAFGKAEEAKKTETGKA----EEA 1114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1538 DKLKKQQKEANTAR--EEAEQELEIwrQKANEALRlrlqaEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKE 1615
Cdd:PTZ00121  1115 RKAEEAKKKAEDARkaEEARKAEDA--RKAEEARK-----AEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEV 1187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1616 NAEKELDKqrkfAEQIAQQKLSAEQECIRLKADFEHAEQQRGLldnELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLL 1695
Cdd:PTZ00121  1188 RKAEELRK----AEDARKAEAARKAEEERKAEEARKAEDAKKA---EAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEA 1260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1696 QMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSV--AEEAKKQrqiAEEeaARQRSEAEKILKEklaAINEAT 1773
Cdd:PTZ00121  1261 RMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKkkADEAKKK---AEE--AKKADEAKKKAEE---AKKKAD 1332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1774 RLKTEAEMALKAKEAenerlkRQAEEEAYQRKLledQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEE 1853
Cdd:PTZ00121  1333 AAKKKAEEAKKAAEA------AKAEAEAAADEA---EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED 1403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1854 ihiikinfhkasKEKADlesELKKLKGIADETQKSKLKAEE--EAEKLKKlaaeeerrrkeaeekvkritAAEEeaarqc 1931
Cdd:PTZ00121  1404 ------------KKKAD---ELKKAAAAKKKADEAKKKAEEkkKADEAKK--------------------KAEE------ 1442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1932 kaaQEEVERLKKKAEDANKqkekaekeaekqvvlAKEAAQKctAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEa 2011
Cdd:PTZ00121  1443 ---AKKADEAKKKAEEAKK---------------AEEAKKK--AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE- 1501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2012 ekakekaekeaalLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKE 2091
Cdd:PTZ00121  1502 -------------AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEE 1568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2092 AEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRR 2171
Cdd:PTZ00121  1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKK 1648

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2172 LMQKDKDSTQKLLAEEAEKMKslAEEAGRLSVE---AEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAE 2248
Cdd:PTZ00121  1649 AEELKKAEEENKIKAAEEAKK--AEEDKKKAEEakkAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEE 1726

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2249 KlqkQKDQAQETAKRLQEDKQQIQQRldKETEGFQKSLEAERKRQLEASAEAEKLKLRV--KELSLAQTKAEDEAKKFKK 2326
Cdd:PTZ00121  1727 E---NKIKAEEAKKEAEEDKKKAEEA--KKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieEELDEEDEKRRMEVDKKIK 1801

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QADEVKAQLQRTEKHTTEIVVQKLETQrLQSTREADDLKSAIADleeerkklkkeaeelQRKSKEMANAQQEQIEQQKAE 2406
Cdd:PTZ00121  1802 DIFDNFANIIEGGKEGNLVINDSKEME-DSAIKEVADSKNMQLE---------------EADAFEKHKFNKNNENGEDGN 1865

                          970       980       990
                   ....*....|....*....|....*....|....*.
gi 1389908296 2407 LQQSFLTEKGLLLKREKEVEgEKKRFEKQLEDEMKK 2442
Cdd:PTZ00121  1866 KEADFNKEKDLKEDDEEEIE-EADEIEKIDKDDIER 1900
PTZ00121 PTZ00121
MAEBL; Provisional
 1667-2531 5.56e-34

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 145.67  E-value: 5.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1667 KNEVNSTEKQR---KQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQllESEALKMKQLADEAARMRSV------- 1736
Cdd:PTZ00121  1063 KAHVGQDEGLKpsyKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEE--ARKAEEAKKKAEDARKAEEArkaedar 1140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1737 -AEEAKKQRQIAEEEAARQRSEAEKI---LKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAA 1812
Cdd:PTZ00121  1141 kAEEARKAEDAKRVEIARKAEDARKAeeaRKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKA 1220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1813 QHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKlkgiADETQKS-KLK 1891
Cdd:PTZ00121  1221 EDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK----AEEKKKAdEAK 1296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1892 AEEEAEKLKKLAAEEERRRKEAEEKVKritaaEEEAARQCKAAQEEVERLKKKAEdANKQKEKAEKEAEKQVVLAKEAAQ 1971
Cdd:PTZ00121  1297 KAEEKKKADEAKKKAEEAKKADEAKKK-----AEEAKKKADAAKKKAEEAKKAAE-AAKAEAEAAADEAEAAEEKAEAAE 1370

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1972 KCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAAlLRQKAEE---AEKQKKAAEnEAAKQAK 2048
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADE-AKKKAEEkkkADEAKKKAE-EAKKADE 1448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2049 AQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKEltvvklqldetdkqkvlldQELQ 2128
Cdd:PTZ00121  1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-------------------AEAK 1509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2129 RVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKmkslAEEAGRLSVEAEET 2208
Cdd:PTZ00121  1510 KKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKK----AEEDKNMALRKAEE 1585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2209 ARQRQiaesnlaeqralaEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEgfqkslea 2288
Cdd:PTZ00121  1586 AKKAE-------------EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE-------- 1644

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2289 ERKRQLEASAEAEKLKLRVKELSlaqTKAEDEakkfKKQADEVKAQlQRTEKHTTEIVVQKLETQrlqstREADDLKSAI 2368
Cdd:PTZ00121  1645 EKKKAEELKKAEEENKIKAAEEA---KKAEED----KKKAEEAKKA-EEDEKKAAEALKKEAEEA-----KKAEELKKKE 1711

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2369 ADleeerkklkkeaeeLQRKSKEMANAqqEQIEQQKAElqqsfltekglLLKREKEVEGEKKRFEKQLEDEMKKAKALKD 2448
Cdd:PTZ00121  1712 AE--------------EKKKAEELKKA--EEENKIKAE-----------EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK 1764

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2449 EQErqrKLMEEERKKLQAIMDEAVrKQKEAEEEMKNKQREMDVLDKKRLEQEKQlAEENKKLREQLQTFEISSKTVSQTK 2528
Cdd:PTZ00121  1765 EEE---KKAEEIRKEKEAVIEEEL-DEEDEKRRMEVDKKIKDIFDNFANIIEGG-KEGNLVINDSKEMEDSAIKEVADSK 1839


                   ...
gi 1389908296 2529 ESQ 2531
Cdd:PTZ00121  1840 NMQ 1842
CH_PLEC_rpt2 cd21238
second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also ...
 111-172 1.24e-33

second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. It can also bind muscle proteins such as actin to membrane complexes in muscle. Plectin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409087  Cd Length: 106  Bit Score: 127.06  E-value: 1.24e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21238     45 PMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMP 106
PTZ00121 PTZ00121
MAEBL; Provisional
 1667-2566 7.65e-33

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 141.82  E-value: 7.65e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1667 KNEVNSTEKQRKQL--EDELNKVRSEMDSLLQMKINAEKASmvnTEKSKQLLESEALKMKQLADEAARMRSV---AEEAK 1741
Cdd:PTZ00121  1052 IDGNHEGKAEAKAHvgQDEGLKPSYKDFDFDAKEDNRADEA---TEEAFGKAEEAKKTETGKAEEARKAEEAkkkAEDAR 1128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1742 KQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEeayQRKLLEDQAAQHKQDIE-- 1819
Cdd:PTZ00121  1129 KAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEE---VRKAEELRKAEDARKAEaa 1205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1820 ---EKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEihiikinfHKASKEKADLESELKKLKGIADETQKSKLKAEEEA 1896
Cdd:PTZ00121  1206 rkaEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEA--------KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEA 1277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1897 EKLKKLAAeeerrrkeaeekvkritAAEEEAARQCKAAQE--EVERLKKKAEDANKQKEKAEKeaekqvvlAKEAAQKCT 1974
Cdd:PTZ00121  1278 RKADELKK-----------------AEEKKKADEAKKAEEkkKADEAKKKAEEAKKADEAKKK--------AEEAKKKAD 1332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1975 AAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEE---AEKQKKAAENEAAKQAKAQN 2051
Cdd:PTZ00121  1333 AAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEkkkADEAKKKAEEDKKKADELKK 1412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2052 DTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKeltvvklqldetdkqkvlldQELQRVK 2131
Cdd:PTZ00121  1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKK--------------------AEEAKKA 1472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2132 GEVNDAFKQKSQVEvelarvriqmeelvKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKmkslAEEAgRLSVEAEETARQ 2211
Cdd:PTZ00121  1473 DEAKKKAEEAKKAD--------------EAKKKAEEAKKKADEAKKAAEAKKKADEAKK----AEEA-KKADEAKKAEEA 1533

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2212 RQIAESNLAEQRALAEKILKekmqaiQEATKlKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERK 2291
Cdd:PTZ00121  1534 KKADEAKKAEEKKKADELKK------AEELK-KAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2292 RQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEV-KAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIAD 2370
Cdd:PTZ00121  1607 MKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEED 1686

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2371 LEEERKklkkeaeelQRKSKEMANAQQEQIEQQKAELQQsflteKGLLLKREKEVEGEK-KRFEKQLEDEMKKAKALKDE 2449
Cdd:PTZ00121  1687 EKKAAE---------ALKKEAEEAKKAEELKKKEAEEKK-----KAEELKKAEEENKIKaEEAKKEAEEDKKKAEEAKKD 1752

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2450 QERQRKLmeEERKKLQAIMDEAVRKQKEAEEEmknkqREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKE 2529
Cdd:PTZ00121  1753 EEEKKKI--AHLKKEEEKKAEEIRKEKEAVIE-----EELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825

                          890       900       910
                   ....*....|....*....|....*....|....*..
gi 1389908296 2530 SQTVSVEKLVAVttvgTSKGVLNGSTEVDGVKKEGDS 2566
Cdd:PTZ00121  1826 EMEDSAIKEVAD----SKNMQLEEADAFEKHKFNKNN 1858
growth_prot_Scy NF041483
polarized growth protein Scy;
1266-2518 6.06e-31

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 134.95  E-value: 6.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEEERRKMAEIQAELdkqkqmaeaHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNI 1345
Cdd:NF041483    91 DAERELRDARAQTQRILQEHAEHQARLQAEL---------HTEAVQRRQQLDQELAERRQTVESHVNENVAWAEQLRART 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1346 QQELQHLKSLSDQEIksknqqlEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAaEAEKLRKAAQDEAer 1425
Cdd:NF041483   162 ESQARRLLDESRAEA-------EQALAAARAEAERLAEEARQRLGSEAESARAEAEAILRRARK-DAERLLNAASTQA-- 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1426 lrkqvaeetQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKirqirVVEEvAQKSAATQL 1505
Cdd:NF041483   232 ---------QEATDHAEQLRSSTAAESDQARRQAAELSRAAEQRMQEAEEALREARAEAEK-----VVAE-AKEAAAKQL 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1506 QTkAMSFSEQTTKleesLKKEQgnVLKLQEEAdklkkqQKEANTAREEAEQ-------ELEIWRQKANEALRlRLQAEEE 1578
Cdd:NF041483   297 AS-AESANEQRTR----TAKEE--IARLVGEA------TKEAEALKAEAEQaladaraEAEKLVAEAAEKAR-TVAAEDT 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1579 AQKKSHAQEEAEKQKLEAERDAKK--RGKAEEAALKQKEnAEKELDKQRKFAEQIAQQKLSA---------------EQE 1641
Cdd:NF041483   363 AAQLAKAARTAEEVLTKASEDAKAttRAAAEEAERIRRE-AEAEADRLRGEAADQAEQLKGAakddtkeyraktvelQEE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1642 CIRLKADfehAEQQRGLLDNELQRLKNE-----VNSTEKQRKQLEDELNKVRSEMDSLLQ-MKINAEKASMVNTEKSKQL 1715
Cdd:NF041483   442 ARRLRGE---AEQLRAEAVAEGERIRGEarreaVQQIEEAARTAEELLTKAKADADELRStATAESERVRTEAIERATTL 518

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1716 LESEALKMKQLADEAARMRSVAEE-AKKQRQIAEEEAARQRSEAEKILKEKLA-AINEATRLKTEAEMALKAKE------ 1787
Cdd:NF041483   519 RRQAEETLERTRAEAERLRAEAEEqAEEVRAAAERAARELREETERAIAARQAeAAEELTRLHTEAEERLTAAEealada 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1788 -AENERLKRQAEEEAYQrklLEDQAAqhkqdieEKITQLQTSSDSElgrqknivEETLKQKKVVEeeihiikinfhkASK 1866
Cdd:NF041483   599 rAEAERIRREAAEETER---LRTEAA-------ERIRTLQAQAEQE--------AERLRTEAAAD------------ASA 648

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1867 EKADLESELKKLKG-IADETQKSKLKAEEEAEKLKklAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQE--------- 1936
Cdd:NF041483   649 ARAEGENVAVRLRSeAAAEAERLKSEAQESADRVR--AEAAAAAERVGTEAAEALAAAQEEAARRRREAEEtlgsaraea 726

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1937 --EVERLKKKAEDANKQKEKAEKEAEKQVV-LAKEAAQKCT----AAEQKAQDVlsknkedvlaqeklRDEFENAKKLAQ 2009
Cdd:NF041483   727 dqERERAREQSEELLASARKRVEEAQAEAQrLVEEADRRATelvsAAEQTAQQV--------------RDSVAGLQEQAE 792

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2010 EAEKAkekaekeaalLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRkeaeeeaarrAAAEAAALKQKQQADAemskhk 2089
Cdd:NF041483   793 EEIAG----------LRSAAEHAAERTRTEAQEEADRVRSDAYAERER----------ASEDANRLRREAQEET------ 846

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2090 kEAEQALQQKSqvekeltvVKLQLDETDKQKVLLDQELQRVKGEVNDAFkqkSQVEVELARVRIQM-EELVKLKLKIEEE 2168
Cdd:NF041483   847 -EAAKALAERT--------VSEAIAEAERLRSDASEYAQRVRTEASDTL---ASAEQDAARTRADArEDANRIRSDAAAQ 914

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2169 NRRLMQKDKDSTQKLLAE---EAEKMKSLA-EEAGRLSVEAEETARQRQIAESNLAEQ-RALAEKILKekmQAIQEATKL 2243
Cdd:NF041483   915 ADRLIGEATSEAERLTAEaraEAERLRDEArAEAERVRADAAAQAEQLIAEATGEAERlRAEAAETVG---SAQQHAERI 991

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2244 KAEAEKLqkqKDQAQETAKRLQEDKQQIQQRLDKETEgfqkslEAERKRQLEASAEAEKLKLRV-----KELSLAQTKAE 2318
Cdd:NF041483   992 RTEAERV---KAEAAAEAERLRTEAREEADRTLDEAR------KDANKRRSEAAEQADTLITEAaaeadQLTAKAQEEAL 1062

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2319 DEAKKFKKQADE-VKAQLQRTEKHTTEIVVQKlETQRLQSTREADDL-------KSAIADLEEERKKLKKEA-----EEL 2385
Cdd:NF041483  1063 RTTTEAEAQADTmVGAARKEAERIVAEATVEG-NSLVEKARTDADELlvgarrdATAIRERAEELRDRITGEieelhERA 1141

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2386 QRKSKEMANAQQEQIEQ--QKAELQQSFLTEKGLLLKREKEVEGEKKRFekqleDEMKKAKALKDEQERQRKLMEEERKK 2463
Cdd:NF041483  1142 RRESAEQMKSAGERCDAlvKAAEEQLAEAEAKAKELVSDANSEASKVRI-----AAVKKAEGLLKEAEQKKAELVREAEK 1216

                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2464 LQAimdEAVRkqkEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLrEQLQTFE 2518
Cdd:NF041483  1217 IKA---EAEA---EAKRTVEEGKRELDVLVRRREDINAEISRVQDVL-EALESFE 1264
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1270-1901 3.97e-30

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 131.98  E-value: 3.97e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1270 RLED--DEKAS--EKLKEEER--RKMAEIQAELDKQKQMAEAHAKSVAKAEQEALElkmkmkEEASKRQDVAADAEKQKQ 1343
Cdd:COG1196    190 RLEDilGELERqlEPLERQAEkaERYRELKEELKELEAELLLLKLRELEAELEELE------AELEELEAELEELEAELA 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1344 NIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIeeeihiiriqlekttahkaksEAELQELRDRAAEAEKLRKAAQDEA 1423
Cdd:COG1196    264 ELEAELEELR----LELEELELELEEAQAEEYEL---------------------LAELARLEQDIARLEERRRELEERL 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1424 ERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQkykmQAEEAERRMKQAEEEKIRQIRvveevAQKSAAT 1503
Cdd:COG1196    319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA----EAEEALLEAEAELAEAEEELE-----ELAEELL 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1504 QLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIwRQKANEALRLRLQAEEEAQKKS 1583
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE-AAEEEAELEEEEEALLELLAEL 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1584 HAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNEL 1663
Cdd:COG1196    469 LEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1664 QRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASmvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQ 1743
Cdd:COG1196    549 QNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAA----ALARGAIGAAVDLVASDLREADARYYVLGDTLLG 624

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1744 RQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKIT 1823
Cdd:COG1196    625 RTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEE 704

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1824 QLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINfhkASKEKADLESELKKLKGIADETQksklkAEEEAEKLKK 1901
Cdd:COG1196    705 EERELAEAEEERLEEELEEEALEEQLEAEREELLEEL---LEEEELLEEEALEELPEPPDLEE-----LERELERLER 774
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1241-1820 1.62e-29

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 130.06  E-value: 1.62e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNLRTRYSEL-MTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALE 1319
Cdd:COG1196    213 ERYRELKEELKELeAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1320 LKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLsDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSE 1399
Cdd:COG1196    293 LLAELARLEQDIARLEERRRELEERLEELEEELAEL-EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1400 AELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRM 1479
Cdd:COG1196    372 AELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1480 KQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQgNVLKLQEEADKLKKQQKEANTAREEAEQELE 1559
Cdd:COG1196    452 AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEA-EADYEGFLEGVKAALLLAGLRGLAGAVAVLI 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1560 IWRQKANEALRLRLQAEEEAQkksHAQEEAEKQKLEAERDAKKRGKAEEAALkqkeNAEKELDKQRKFAEQIAQQKLSAE 1639
Cdd:COG1196    531 GVEAAYEAALEAALAAALQNI---VVEDDEVAAAAIEYLKAAKAGRATFLPL----DKIRARAALAAALARGAIGAAVDL 603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1640 QECIRLKADFEHAEQQRGLLDNELQRLKNEvnSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKAsmvnTEKSKQLLESE 1719
Cdd:COG1196    604 VASDLREADARYYVLGDTLLGRTLVAARLE--AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGS----RRELLAALLEA 677

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1720 ALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEE 1799
Cdd:COG1196    678 EAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELP 757

                          570       580
                   ....*....|....*....|.
gi 1389908296 1800 EAYQRKLLEDQAAQHKQDIEE 1820
Cdd:COG1196    758 EPPDLEELERELERLEREIEA 778
PTZ00121 PTZ00121
MAEBL; Provisional
 1028-1894 2.26e-27

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 123.71  E-value: 2.26e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1028 AEETLKNYEARLRDVSKVPSEQKEVEKHRSQMKSMRSE-----AEADQVMFDRLQDDLRKAttvhDKMTRIHSERDADLE 1102
Cdd:PTZ00121  1100 AEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEdarkaEEARKAEDAKRVEIARKA----EDARKAEEARKAEDA 1175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1103 HYRQLVNGLLERWQAvfaqielRLRELDLLGRHMNSYRDSYEwlIRWLTEARQRQEKIQAVPISDSRALREQLTDEKKll 1182
Cdd:PTZ00121  1176 KKAEAARKAEEVRKA-------EELRKAEDARKAEAARKAEE--ERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKK-- 1244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1183 GEIEKNKDKIDDCHKNAKAYidsvkdYEFQILTYKALQDPIASPLKKPKMECASDDIiqeyvnlrtRYSELMTLTNQYIK 1262
Cdd:PTZ00121  1245 AEEERNNEEIRKFEEARMAH------FARRQAAIKAEEARKADELKKAEEKKKADEA---------KKAEEKKKADEAKK 1309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1263 FIIDAQRRLEDDEKASE-KLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRqdvaADAEKQ 1341
Cdd:PTZ00121  1310 KAEEAKKADEAKKKAEEaKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKK----ADAAKK 1385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1342 KQNIQQELQHLKSLSdQEIKSKNQQLEDALVSRRKIEEEIHIIRiqlEKTTAHKAKSEAElqelrdRAAEAEKLRKAAQD 1421
Cdd:PTZ00121  1386 KAEEKKKADEAKKKA-EEDKKKADELKKAAAAKKKADEAKKKAE---EKKKADEAKKKAE------EAKKADEAKKKAEE 1455

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1422 --EAERLRKQvAEETQR----KKNAEDelKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEE 1495
Cdd:PTZ00121  1456 akKAEEAKKK-AEEAKKadeaKKKAEE--AKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEE 1532

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1496 VAQKSAATQlqtkamsfSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLrlqA 1575
Cdd:PTZ00121  1533 AKKADEAKK--------AEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKL---Y 1601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1576 EEEAQKKSHAQEEAEKQKLEAERDAK-KRGKAEEAALKQKENAEKELDKQRKFAEQiaQQKLSAEQECIRLKADFEHAEQ 1654
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKaEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIKAAEEAKKAEEDKKKAEE 1679

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1655 QRGllDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMR 1734
Cdd:PTZ00121  1680 AKK--AEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKK 1757

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1735 SVAEEAKKQRQIAEEeaarQRSEAEKILKEKLAAINEATRLKTE---------AEMALKAKEAENERLKRQAEEEAYQRK 1805
Cdd:PTZ00121  1758 KIAHLKKEEEKKAEE----IRKEKEAVIEEELDEEDEKRRMEVDkkikdifdnFANIIEGGKEGNLVINDSKEMEDSAIK 1833

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1806 LLEDQAAQHKQDIEEkITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESEL--KKLKGIAD 1883
Cdd:PTZ00121  1834 EVADSKNMQLEEADA-FEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIpnNNMAGKNN 1912

                          890
                   ....*....|.
gi 1389908296 1884 ETQKSKLKAEE 1894
Cdd:PTZ00121  1913 DIIDDKLDKDE 1923
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1428-2334 3.16e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.86  E-value: 3.16e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1428 KQVAEETQRK-KNAEDELKRKSDAEKEAAKQkqralddLQKYKMQAEEAER-RMKQAEEEKIR---QIRVVEEVAQKSAA 1502
Cdd:TIGR02168  171 KERRKETERKlERTRENLDRLEDILNELERQ-------LKSLERQAEKAERyKELKAELRELElalLVLRLEELREELEE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1503 TQLQTKAM-----SFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEE 1577
Cdd:TIGR02168  244 LQEELKEAeeeleELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1578 EaqkkshaQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRG 1657
Cdd:TIGR02168  324 Q-------LEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1658 LLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSL----LQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARM 1733
Cdd:TIGR02168  397 SLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAelkeLQAELEELEEELEELQEELERLEEALEELREELEEAEQA 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1734 RSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENerlKRQAEEEAYQRKLLEDQAAQ 1813
Cdd:TIGR02168  477 LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDE---GYEAAIEAALGGRLQAVVVE 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1814 HKQDIEEKITQLqtsSDSELGRQKNIVEETLKQKKVVEEEIHIIKiNFHKASKEKADLESELKKLKG----------IAD 1883
Cdd:TIGR02168  554 NLNAAKKAIAFL---KQNELGRVTFLPLDSIKGTEIQGNDREILK-NIEGFLGVAKDLVKFDPKLRKalsyllggvlVVD 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1884 ETQksklkaeeEAEKLKKLAAEEERRRKEAEEKVKR---ITAAEEEAARQCKAAQEEVERLKKKAEdankqkekaekeae 1960
Cdd:TIGR02168  630 DLD--------NALELAKKLRPGYRIVTLDGDLVRPggvITGGSAKTNSSILERRREIEELEEKIE-------------- 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1961 kqvvlakEAAQKCTAAEQKAQDVLSKnkedvlaQEKLRDEFENAKKLAQEaekakekaekeaalLRQKAEEAEKQKKAAE 2040
Cdd:TIGR02168  688 -------ELEEKIAELEKALAELRKE-------LEELEEELEQLRKELEE--------------LSRQISALRKDLARLE 739

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2041 NEAAKQAKAQNDTEKQRKEAEeeaarraaaeaaalKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQK 2120
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELE--------------AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2121 VLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEEnrrlmqkdkdstqklLAEEAEKMKSLAEEAGR 2200
Cdd:TIGR02168  806 DELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSED---------------IESLAAEIEELEELIEE 870

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2201 LSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQEtakRLQEDKQQIQQRLDKETE 2280
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLEL---RLEGLEVRIDNLQERLSE 947

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 2281 GFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTK-------AEDEAKKFKKQADEVKAQ 2334
Cdd:TIGR02168  948 EYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQ 1008
CH_DYST_rpt2 cd21239
second calponin homology (CH) domain found in dystonin and similar proteins; Dystonin, also ...
 111-172 4.38e-27

second calponin homology (CH) domain found in dystonin and similar proteins; Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. Dystonin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409088  Cd Length: 104  Bit Score: 108.15  E-value: 4.38e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAEReLGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21239     44 PDLIDMNTVAVQSNLANLEHAFYVAEK-LGVTRLLDPEDVDVSSPDEKSVITYVSSLYDVFP 104
PTZ00121 PTZ00121
MAEBL; Provisional
 1028-1825 8.39e-27

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 121.79  E-value: 8.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1028 AEETLKNYEARLRDVSKVPSEQKEVEKHRSQMKSMRSEaEADQVMFDRLQDDLRKATTVH--DKMTRIHSERDADLEHYR 1105
Cdd:PTZ00121  1136 AEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAE-DAKKAEAARKAEEVRKAEELRkaEDARKAEAARKAEEERKA 1214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1106 QLVNGLLERWQAVFAQIELRLRELDLLGRHMNSYRDSYEwlIRWLTEAR-----QRQEKIQAVPISDSRALRE------- 1173
Cdd:PTZ00121  1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEE--IRKFEEARmahfaRRQAAIKAEEARKADELKKaeekkka 1292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1174 ---QLTDEKKLLGEIEKN----------KDKIDDCHKNAKAYIDSVKDYEFQILTYKALQDPIASPLKKPKMECASDDII 1240
Cdd:PTZ00121  1293 deaKKAEEKKKADEAKKKaeeakkadeaKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK 1372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNlrtRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLK--EEERRKMAEIQAELDKQKQMAEAHAKsvAKAEQEAL 1318
Cdd:PTZ00121  1373 KEEAK---KKADAAKKKAEEKKKADEAKKKAEEDKKKADELKkaAAAKKKADEAKKKAEEKKKADEAKKK--AEEAKKAD 1447

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1319 ELKmKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKS 1398
Cdd:PTZ00121  1448 EAK-KKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE 1526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELR--DRAAEAEKLRKAAQ-DEAERLRK--QVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAE 1473
Cdd:PTZ00121  1527 AKKAEEAKkaDEAKKAEEKKKADElKKAEELKKaeEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 EAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAmsfSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREE 1553
Cdd:PTZ00121  1607 MKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKE---AEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKA 1683

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1554 AEQEleiwrQKANEALRlrlQAEEEAQKKshaqEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQ 1633
Cdd:PTZ00121  1684 EEDE-----KKAAEALK---KEAEEAKKA----EELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKK 1751

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1634 QklsaEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKsk 1713
Cdd:PTZ00121  1752 D----EEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK-- 1825

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1714 qllESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQ-----RSEAEKILKEKLAAINEATRLKTEAEMALKAKEA 1788
Cdd:PTZ00121  1826 ---EMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDgnkeaDFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902

                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 1389908296 1789 ENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQL 1825
Cdd:PTZ00121  1903 PNNNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIKI 1939
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1467-2135 9.91e-27

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 120.81  E-value: 9.91e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEE--EKIRQIRvvEEVAQksaatQLqtkamsfseqttkleESLKKEQGNVLK---LQEEADKLK 1541
Cdd:COG1196    169 KYKERKEEAERKLEATEEnlERLEDIL--GELER-----QL---------------EPLERQAEKAERyreLKEELKELE 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1542 KQQKEAntAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKEL 1621
Cdd:COG1196    227 AELLLL--KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDI 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1622 DKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQmKINA 1701
Cdd:COG1196    305 ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE-ELEE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1702 EKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEAtrlkTEAEM 1781
Cdd:COG1196    384 LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEE 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1782 ALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIhiikinf 1861
Cdd:COG1196    460 ALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV------- 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1862 hKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKlaaeeerrrkeaeekvKRITAAEEEAARQCKAAQEEVERL 1941
Cdd:COG1196    533 -EAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA----------------GRATFLPLDKIRARAALAAALARG 595

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1942 KKKAEDANKQKEKAEKEAEKQVVLAKEAaqkctAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKE 2021
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDTLL-----GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRREL 670

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2022 AALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQ 2101
Cdd:COG1196    671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEE 750

                          650       660       670
                   ....*....|....*....|....*....|....
gi 1389908296 2102 VEKELTVVKLQLDETDKQKVLLDQELQRvKGEVN 2135
Cdd:COG1196    751 EALEELPEPPDLEELERELERLEREIEA-LGPVN 783
CH_SYNE1_rpt2 cd21243
second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and ...
 111-172 3.55e-26

second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins; SYNE-1, also called nesprin-1, enaptin, KASH domain-containing protein 1 (KASH1), myocyte nuclear envelope protein 1 (MYNE-1), or nuclear envelope spectrin repeat protein 1, is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. SYNE-1 also acts as a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. SYNE-1 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409092  Cd Length: 109  Bit Score: 105.48  E-value: 3.55e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21243     48 PDLVDMESLKRRSNRENLETAFTVAEKELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKKYP 109
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1467-2330 3.76e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 119.39  E-value: 3.76e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRVVEEvaqksaatqlqtkamsfseqttkLEESLKKeqgnvLKLQ-EEADKLKKQQK 1545
Cdd:TIGR02168  169 KYKERRKETERKLERTRENLDRLEDILNE-----------------------LERQLKS-----LERQaEKAERYKELKA 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1546 EantaREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEeaALKQKENAEKELdkqr 1625
Cdd:TIGR02168  221 E----LRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSE--LEEEIEELQKEL---- 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1626 kfaeqiaqQKLSAEQEciRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQmkinaekas 1705
Cdd:TIGR02168  291 --------YALANEIS--RLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKE--------- 351

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1706 mvntekskqllesealKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMAlka 1785
Cdd:TIGR02168  352 ----------------ELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL--- 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1786 kEAENERLKRQAEEEayQRKLLEDQAAQHKQDIEEKITQLqtssdselgrqknivEETLKQKKVVEEEIHIIKINFHKAS 1865
Cdd:TIGR02168  413 -EDRRERLQQEIEEL--LKKLEEAELKELQAELEELEEEL---------------EELQEELERLEEALEELREELEEAE 474

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1866 KEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEE-------------------- 1925
Cdd:TIGR02168  475 QALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGyeaaieaalggrlqavvven 554

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1926 -EAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENA 2004
Cdd:TIGR02168  555 lNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNA 634

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2005 KKLAQEAEKAKEKAEKEAALL--------------------RQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEA 2064
Cdd:TIGR02168  635 LELAKKLRPGYRIVTLDGDLVrpggvitggsaktnssilerRREIEELEEKIEELEEKIAELEKALAELRKELEELEEEL 714

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2065 ARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNdafKQKSQV 2144
Cdd:TIGR02168  715 EQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE---ELEAQI 791

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2145 EVELARVRIQMEELVKLKLKIEEENRRLMQK--DKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQ 2222
Cdd:TIGR02168  792 EQLKEELKALREALDELRAELTLLNEEAANLreRLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEL 871

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2223 RALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKsLEAERKRQLEASAEAEK 2302
Cdd:TIGR02168  872 ESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSEEYS 950

                          890       900       910
                   ....*....|....*....|....*....|...
gi 1389908296 2303 LKL-----RVKELSLAQTKAEDEAKKFKKQADE 2330
Cdd:TIGR02168  951 LTLeeaeaLENKIEDDEEEARRRLKRLENKIKE 983
PTZ00121 PTZ00121
MAEBL; Provisional
 1923-2575 7.45e-26

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 118.71  E-value: 7.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1923 AEEEAARQCKAAQEE--VERLKKKAEDANKQKEKAEKEAEKQVVLAKEA-----------------AQKCTAAEQKAQDV 1983
Cdd:PTZ00121  1100 AEEAKKTETGKAEEArkAEEAKKKAEDARKAEEARKAEDARKAEEARKAedakrveiarkaedarkAEEARKAEDAKKAE 1179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1984 LSKNKEDVLAQEKLR--------------DEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQ--- 2046
Cdd:PTZ00121  1180 AARKAEEVRKAEELRkaedarkaeaarkaEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKfee 1259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2047 --------AKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHK----KEAEQALQQKSQVEKELTVVKLQLD 2114
Cdd:PTZ00121  1260 armahfarRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKaeeaKKADEAKKKAEEAKKKADAAKKKAE 1339

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2115 ETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVK----------LKLKIEEENRRLMQKDKDSTQKLL 2184
Cdd:PTZ00121  1340 EAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKkaeekkkadeAKKKAEEDKKKADELKKAAAAKKK 1419

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2185 AEEAEKMKSLAEEAGRLSVEAEETARQRQIAESnlAEQRALAEKILK--EKMQAIQEATKLKAEAEKLQKQKDQAQETAK 2262
Cdd:PTZ00121  1420 ADEAKKKAEEKKKADEAKKKAEEAKKADEAKKK--AEEAKKAEEAKKkaEEAKKADEAKKKAEEAKKADEAKKKAEEAKK 1497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2263 RLQEDKQQIQQRldKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHT 2342
Cdd:PTZ00121  1498 KADEAKKAAEAK--KKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEED 1575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2343 TEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKRE 2422
Cdd:PTZ00121  1576 KNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA 1655

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2423 KEVEGEKKRFE-KQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQ-REMDVLDKKRLEQE 2500
Cdd:PTZ00121  1656 EEENKIKAAEEaKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEElKKAEEENKIKAEEA 1735

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2501 KQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKL----VAVTTVGTSKGVLNGSTEVDgvKKEGDSPLSFEGIRE 2575
Cdd:PTZ00121  1736 KKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIrkekEAVIEEELDEEDEKRRMEVD--KKIKDIFDNFANIIE 1812
growth_prot_Scy NF041483
polarized growth protein Scy;
1407-2510 1.63e-25

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 117.23  E-value: 1.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1407 DRAAEAEKLRKAAQDEAERLRkqvaeetqrkKNAEDELkrksdaeKEAAKQKQRALDDL--QKYKMQAE---EAERRMKQ 1481
Cdd:NF041483    69 DIGYQAEQLLRNAQIQADQLR----------ADAEREL-------RDARAQTQRILQEHaeHQARLQAElhtEAVQRRQQ 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1482 AEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQ-----QKEANTAREEAEQ 1556
Cdd:NF041483   132 LDQELAERRQTVESHVNENVAWAEQLRARTESQARRLLDESRAEAEQALAAARAEAERLAEEarqrlGSEAESARAEAEA 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1557 eleIWRQKANEALRLRLQAEEEAQK-KSHAQ----------EEAEKQKLEAERDAKKRGKAEEAALKQkenAEKELDKQR 1625
Cdd:NF041483   212 ---ILRRARKDAERLLNAASTQAQEaTDHAEqlrsstaaesDQARRQAAELSRAAEQRMQEAEEALRE---ARAEAEKVV 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1626 KFAEQIAQQKLSAEQECirlkadfehAEQQRGLLDNELQRLKNE-VNSTEKQRKQLEDELNKVRSEMDSLLQMKinAEKA 1704
Cdd:NF041483   286 AEAKEAAAKQLASAESA---------NEQRTRTAKEEIARLVGEaTKEAEALKAEAEQALADARAEAEKLVAEA--AEKA 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1705 SMVNTEKS-----KQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKE-KLAAIN-------- 1770
Cdd:NF041483   355 RTVAAEDTaaqlaKAARTAEEVLTKASEDAKATTRAAAEEAERIRREAEAEADRLRGEAADQAEQlKGAAKDdtkeyrak 434

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1771 ------EATRLKTEAEMALKAKEAENERLKRQAEEEAYQR-----KLLEDQAAQHKQDIEEkiTQLQTSSDSELGRQKNI 1839
Cdd:NF041483   435 tvelqeEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQieeaaRTAEELLTKAKADADE--LRSTATAESERVRTEAI 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1840 ---------VEETLKQKKvVEEEIHIIKINfHKASKEKADLESELKKLKgiADETQKSKLKAEEEAEKLKKLAAEEErrr 1910
Cdd:NF041483   513 erattlrrqAEETLERTR-AEAERLRAEAE-EQAEEVRAAAERAARELR--EETERAIAARQAEAAEELTRLHTEAE--- 585

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1911 keaeekvKRITAAEE-------EAARQCKAAQEEVERLkkKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDV 1983
Cdd:NF041483   586 -------ERLTAAEEaladaraEAERIRREAAEETERL--RTEAAERIRTLQAQAEQEAERLRTEAAADASAARAEGENV 656

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1984 LSKNKEDVLAQ-EKLRDEFENAKKlaqeaekakekaekeaallRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKeaee 2062
Cdd:NF041483   657 AVRLRSEAAAEaERLKSEAQESAD-------------------RVRAEAAAAAERVGTEAAEALAAAQEEAARRRR---- 713

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2063 eaarraaaeaaalkqkqQADAEMSKHKKEAEQALQQ-KSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQK 2141
Cdd:NF041483   714 -----------------EAEETLGSARAEADQERERaREQSEELLASARKRVEEAQAEAQRLVEEADRRATELVSAAEQT 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2142 SQ-VEVELARVRIQM-EELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEA-EETARQRQIAESN 2218
Cdd:NF041483   777 AQqVRDSVAGLQEQAeEEIAGLRSAAEHAAERTRTEAQEEADRVRSDAYAERERASEDANRLRREAqEETEAAKALAERT 856

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2219 LAEQRALAEKILKEK---------------MQAIQEATKLKAEA-EKLQKQKDQAQETAKRL------QEDKQQIQQRLD 2276
Cdd:NF041483   857 VSEAIAEAERLRSDAseyaqrvrteasdtlASAEQDAARTRADArEDANRIRSDAAAQADRLigeatsEAERLTAEARAE 936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2277 KETEGFQKSLEAERKR----------QLEASAEAEKLKLRVKE-LSLAQTKAE---DEAKKFKKQADEVKAQLQRTEKHT 2342
Cdd:NF041483   937 AERLRDEARAEAERVRadaaaqaeqlIAEATGEAERLRAEAAEtVGSAQQHAErirTEAERVKAEAAAEAERLRTEAREE 1016

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2343 TEIVVQklETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIE------QQKAELQQSFLTEKG 2416
Cdd:NF041483  1017 ADRTLD--EARKDANKRRSEAAEQADTLITEAAAEADQLTAKAQEEALRTTTEAEAQADtmvgaaRKEAERIVAEATVEG 1094

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2417 LLLkrekeVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAimdeavRKQKEAEEEMKNKQREMDVLDKKR 2496
Cdd:NF041483  1095 NSL-----VEKARTDADELLVGARRDATAIRERAEELRDRITGEIEELHE------RARRESAEQMKSAGERCDALVKAA 1163

                         1210
                   ....*....|....
gi 1389908296 2497 LEQEKQLAEENKKL 2510
Cdd:NF041483  1164 EEQLAEAEAKAKEL 1177
CH_MACF1_rpt2 cd21240
second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, ...
 111-172 2.48e-25

second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins; MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. MACF1 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409089  Cd Length: 107  Bit Score: 103.20  E-value: 2.48e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAEReLGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21240     47 PDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFP 107
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1269-2031 2.81e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 2.81e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1269 RRLEDDEKASEKL-----KEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEeaskrqdvaadAEKQKQ 1343
Cdd:TIGR02168  216 KELKAELRELELAllvlrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSE-----------LEEEIE 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1344 NIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEA 1423
Cdd:TIGR02168  285 ELQKELYALA----NEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1424 ERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRAlddlqkyKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAAT 1503
Cdd:TIGR02168  361 EELEAELEELESRLEELEEQLETLRSKVAQLELQIASL-------NNEIERLEARLERLEDRRERLQQEIEELLKKLEEA 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1504 QLQTKAMSFSEqttkLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKs 1583
Cdd:TIGR02168  434 ELKELQAELEE----LEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGV- 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1584 hAQEEAEKQKLEAERD--------AKKRGKAEEAALK--------------------QKENAEK-----ELDKQRKFAEQ 1630
Cdd:TIGR02168  509 -KALLKNQSGLSGILGvlselisvDEGYEAAIEAALGgrlqavvvenlnaakkaiafLKQNELGrvtflPLDSIKGTEIQ 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1631 IAQQKLSAEQECIRLKAD--FEHAEQQRGLLDNELQRLK--NEVNSTEKQRKQLEDELNKVRSEMDSLLQ---MKINAEK 1703
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKdlVKFDPKLRKALSYLLGGVLvvDDLDNALELAKKLRPGYRIVTLDGDLVRPggvITGGSAK 667

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1704 ASMVNTEKSKQLLESEAlKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMAL 1783
Cdd:TIGR02168  668 TNSSILERRREIEELEE-KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1784 KAKEAENERLKRQAEEEAYQRKLLEdQAAQHKQDIEEKITQLQtssdSELGRQKNIVEETLKQKKVVEEEIHIIKINFHK 1863
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLE-EAEEELAEAEAEIEELE----AQIEQLKEELKALREALDELRAELTLLNEEAAN 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1864 ASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKK 1943
Cdd:TIGR02168  822 LRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSE 901

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1944 KAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKnkedvlAQEKLRDEFENAKKLAQEAEKAKEKAEKEAA 2023
Cdd:TIGR02168  902 ELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQER------LSEEYSLTLEEAEALENKIEDDEEEARRRLK 975


                   ....*...
gi 1389908296 2024 LLRQKAEE 2031
Cdd:TIGR02168  976 RLENKIKE 983
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1607-2534 3.00e-25

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 116.22  E-value: 3.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1607 EEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNK 1686
Cdd:pfam02463  172 KEALKKLIEETENLAELIIDLEELKLQELKLKEQA---KKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1687 VRSEMDSLLQmKINAEKASMvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKL 1766
Cdd:pfam02463  249 EQEEIESSKQ-EIEKEEEKL---AQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1767 AAINEATRLKTEAEMALKAKEaENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQ 1846
Cdd:pfam02463  325 KAEKELKKEKEEIEELEKELK-ELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1847 KKVVEEEIHIIKINFHKASKEKadlESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEE 1926
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEK---KEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLV 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1927 AARQCKaaQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLaqeKLRDEFENAKK 2006
Cdd:pfam02463  481 KLQEQL--ELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVA---ISTAVIVEVSA 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2007 LAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMS 2086
Cdd:pfam02463  556 TADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2087 KHKKEAeqalqqKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIE 2166
Cdd:pfam02463  636 KLKESA------KAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREK 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2167 EENRRLMQKDKDSTQKLLAEEAEKmkslaeeagrlsvEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAE 2246
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDK-------------INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKEL 776

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2247 AEKLQKQKDQAQETAKRLQEdkqqiqqrldketegfqKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKK 2326
Cdd:pfam02463  777 AEEREKTEKLKVEEEKEEKL-----------------KAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELA 839

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QaDEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAE 2406
Cdd:pfam02463  840 L-ELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENE 918

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2407 LQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQER-QRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNK 2485
Cdd:pfam02463  919 IEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRlLLAKEELGKVNLMAIEEFEEKEERYNKDELEKE 998

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*....
gi 1389908296 2486 QREMDVLDKKRLEQEkqlaEENKKLREQLQTFEISSKTVSQTKESQTVS 2534
Cdd:pfam02463  999 RLEEEKKKLIRAIIE----ETCQRLKEFLELFVSINKGWNKVFFYLELG 1043
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1241-1941 5.34e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 115.54  E-value: 5.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNLRTRYSEL-MTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELD-KQKQMAEAHAKsVAKAEQEAL 1318
Cdd:TIGR02168  213 ERYKELKAELRELeLALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEeLRLEVSELEEE-IEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1319 ELKMKmkeeaskrqdvAADAEKQKQNIQQELQHLkslsDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKS 1398
Cdd:TIGR02168  292 ALANE-----------ISRLEQQKQILRERLANL----ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDEL----KRKSDAEKEAAKQKQRALD--------DLQ 1466
Cdd:TIGR02168  357 EAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIerleARLERLEDRRERLQQEIEEllkkleeaELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRVVEEV-AQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQK 1545
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELrEELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1546 EANTAREEAEQELEI---WRQKANEALRLRLQA-----EEEAQKKSHAQEEAEKQK-----LEAERDAKKRGKAEEAaLK 1612
Cdd:TIGR02168  517 GLSGILGVLSELISVdegYEAAIEAALGGRLQAvvvenLNAAKKAIAFLKQNELGRvtflpLDSIKGTEIQGNDREI-LK 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1613 QKENAEKELDKQRKFAEQ---------------------IAQQKLSAEQECI------RLKAD----FEHAEQQRGLL-- 1659
Cdd:TIGR02168  596 NIEGFLGVAKDLVKFDPKlrkalsyllggvlvvddldnaLELAKKLRPGYRIvtldgdLVRPGgvitGGSAKTNSSILer 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1660 DNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQM-------------KINAEKASMVNTEKSKQLLESE------- 1719
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEEleqlrkeleelsrQISALRKDLARLEAEVEQLEERiaqlske 755

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1720 ----ALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEA---EMALKAKEAENER 1792
Cdd:TIGR02168  756 ltelEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAanlRERLESLERRIAA 835

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1793 LKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSelgrqkniVEETLKQKKVVEEEIHIIKINFHKASKEKADLE 1872
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE--------LEALLNERASLEEALALLRSELEELSEELRELE 907

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1873 SELKKLKGIADETQKSKLKAEEEAEKLK--------KLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERL 1941
Cdd:TIGR02168  908 SKRSELRRELEELREKLAQLELRLEGLEvridnlqeRLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1535-2373 1.16e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 114.38  E-value: 1.16e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1535 EEA---DKLKKQQKEANTAREEAEQEL--------EIWRQKAnealRLRLQAE--EEAQKKSHAQEEAEKQKLEAERDAK 1601
Cdd:TIGR02168  162 EEAagiSKYKERRKETERKLERTRENLdrledilnELERQLK----SLERQAEkaERYKELKAELRELELALLVLRLEEL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1602 KRgKAEEAALKQKENAEKELDKQRKFAEqiAQQKLSaEQECIRLKADFEHAEQQRGLLD--NELQRLKNEVNSTEKQRKQ 1679
Cdd:TIGR02168  238 RE-ELEELQEELKEAEEELEELTAELQE--LEEKLE-ELRLEVSELEEEIEELQKELYAlaNEISRLEQQKQILRERLAN 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1680 LEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLEsealKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAE 1759
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELKE----ELESLEAELEELEAELEELESRLEELEEQLETLRSKVA 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1760 KILKEKLAAINEATRLKTEAEMAlkakEAENERLKRQAEEEayQRKLLEDQAAQHKQDIEEKITQLqtssdselgrqkni 1839
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARLERL----EDRRERLQQEIEEL--LKKLEEAELKELQAELEELEEEL-------------- 449

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1840 vEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKR 1919
Cdd:TIGR02168  450 -EELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSEL 528

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1920 ITAAEE---------------------EAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQ 1978
Cdd:TIGR02168  529 ISVDEGyeaaieaalggrlqavvvenlNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLV 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1979 KAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALL--------------------RQKAEEAEKQKKA 2038
Cdd:TIGR02168  609 KFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDGDLVrpggvitggsaktnssilerRREIEELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2039 AENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDK 2118
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2119 QKVLLDQELQRVKGEVNdafKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQK--DKDSTQKLLAEEAEKMKSLAE 2196
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIE---ELEAQIEQLKEELKALREALDELRAELTLLNEEAANLreRLESLERRIAATERRLEDLEE 845

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2197 EAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLD 2276
Cdd:TIGR02168  846 QIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLA 925

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2277 KETEGFQKsLEAERKRQLEASAEAEKLklrvkELSLAQTKAEDEAKKFKKQADEVKaQLQRTEKHTTEIVVQKLETQRLQ 2356
Cdd:TIGR02168  926 QLELRLEG-LEVRIDNLQERLSEEYSL-----TLEEAEALENKIEDDEEEARRRLK-RLENKIKELGPVNLAAIEEYEEL 998

                          890
                   ....*....|....*..
gi 1389908296 2357 STREaDDLKSAIADLEE 2373
Cdd:TIGR02168  999 KERY-DFLTAQKEDLTE 1014
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1671-2470 1.17e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 110.92  E-value: 1.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1671 NSTEKQRKQLEDELNKVRSEMDSLlqmKINAEKAsmvntEKSKQLleSEALKMKQLADEAARMRSvAEEAKKQRQIAEEE 1750
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSL---ERQAEKA-----ERYKEL--KAELRELELALLVLRLEE-LREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1751 AARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQtssd 1830
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE---- 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1831 sELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIAD---ETQKSKLKAEEEAE-----KLKKL 1902
Cdd:TIGR02168  327 -ELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEeqlETLRSKVAQLELQIaslnnEIERL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1903 AAEEERRRKEAEEKVKRITAAEEEAAR-QCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQ 1981
Cdd:TIGR02168  406 EARLERLEDRRERLQQEIEELLKKLEEaELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1982 DVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEkeaaLLRQKAEEAEKQKKAAE--------------NEAAKQA 2047
Cdd:TIGR02168  486 QLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILG----VLSELISVDEGYEAAIEaalggrlqavvvenLNAAKKA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2048 KA---QNDTEKQ-----RKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAE-----------------QALQQKSQV 2102
Cdd:TIGR02168  562 IAflkQNELGRVtflplDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvddldNALELAKKL 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2103 EKELTVVKLQLD-------------ETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEEL----VKLKLKI 2165
Cdd:TIGR02168  642 RPGYRIVTLDGDlvrpggvitggsaKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELeeelEQLRKEL 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2166 EEENRRLmqkdkDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKA 2245
Cdd:TIGR02168  722 EELSRQI-----SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2246 EAEKLQKQKDQAQETAKRLQEDKQQIQQRLD---KETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAK 2322
Cdd:TIGR02168  797 ELKALREALDELRAELTLLNEEAANLRERLEsleRRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2323 KFKKQADEVKAQLQ--RTEKHTTEIVVQKLETQRLQSTREADDLKSAIADleeerkklkkeaeelqrkskemANAQQEQI 2400
Cdd:TIGR02168  877 ALLNERASLEEALAllRSELEELSEELRELESKRSELRRELEELREKLAQ----------------------LELRLEGL 934

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2401 EQQKAELQQSFLTEKGLLL-----------KREKEVEGEKKRFEKQLE----------DEMKKAKALKDEQERQRKLMEE 2459
Cdd:TIGR02168  935 EVRIDNLQERLSEEYSLTLeeaealenkieDDEEEARRRLKRLENKIKelgpvnlaaiEEYEELKERYDFLTAQKEDLTE 1014

                          890
                   ....*....|.
gi 1389908296 2460 ERKKLQAIMDE 2470
Cdd:TIGR02168 1015 AKETLEEAIEE 1025
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1241-2107 1.47e-22

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 107.36  E-value: 1.47e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALEL 1320
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1321 -KMKMKEEASKRQDVAADAEKQKQN---------IQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEK 1390
Cdd:pfam02463  246 lRDEQEEIESSKQEIEKEEEKLAQVlkenkeeekEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1391 TTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQ----RALDDLQ 1466
Cdd:pfam02463  326 AEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEeeleLKSEEEK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKE 1546
Cdd:pfam02463  406 EAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQ 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1547 ANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRK 1626
Cdd:pfam02463  486 LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQK 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1627 FAEQIAQQKLSAEQECIRLKADFE----HAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAE 1702
Cdd:pfam02463  566 LVRALTELPLGARKLRLLIPKLKLplksIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKE 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1703 KASMVNTEKSKQLLESEALKMKQLADeaaRMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEma 1782
Cdd:pfam02463  646 SGLRKGVSLEEGLAEKSEVKASLSEL---TKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAE-- 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1783 lkakEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGR---QKNIVEETLKQKKVVEEEIHIIKI 1859
Cdd:pfam02463  721 ----ELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELslkEKELAEEREKTEKLKVEEEKEEKL 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1860 NFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVE 1939
Cdd:pfam02463  797 KAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1940 RLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQ----KAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAK 2015
Cdd:pfam02463  877 EELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKeneiEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKE 956

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2016 EKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADA---EMSKHKKEA 2092
Cdd:pfam02463  957 EEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLElfvSINKGWNKV 1036

                          890
                   ....*....|....*
gi 1389908296 2093 EQALQQKSQVEKELT 2107
Cdd:pfam02463 1037 FFYLELGGSAELRLE 1051
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1774-2340 1.77e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.94  E-value: 1.77e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1774 RLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQtssdsELGRQKNIVEETLKQKKvveEE 1853
Cdd:COG1196    204 PLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELE-----ELEAELAELEAELEELR---LE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1854 IHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKlaaeeerRRKEAEEKVKRITAAEEEAARQCKA 1933
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE-------ELAELEEELEELEEELEELEEELEE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1934 AQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEK 2013
Cdd:COG1196    349 AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2014 AKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQ---KQQADAEMSKHKK 2090
Cdd:COG1196    429 ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARlllLLEAEADYEGFLE 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2091 EAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVR------IQMEELVKLKLK 2164
Cdd:COG1196    509 GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKagratfLPLDKIRARAAL 588

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2165 IEEENRRLMQKDKDSTQKLLAEEAEKMKSL-------------AEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILK 2231
Cdd:COG1196    589 AAALARGAIGAAVDLVASDLREADARYYVLgdtllgrtlvaarLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR 668

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2232 EKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELS 2311
Cdd:COG1196    669 ELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELL 748

                          570       580
                   ....*....|....*....|....*....
gi 1389908296 2312 LAQTKAEDEAkkfKKQADEVKAQLQRTEK 2340
Cdd:COG1196    749 EEEALEELPE---PPDLEELERELERLER 774
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1871-2470 3.55e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 3.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1871 LESELKKLKGIADETQKSK-LKAEE---EAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAE 1946
Cdd:COG1196    198 LERQLEPLERQAEKAERYReLKEELkelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELE 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1947 DANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLR 2026
Cdd:COG1196    278 ELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2027 QKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKEL 2106
Cdd:COG1196    358 AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2107 TVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDST-QKLLA 2185
Cdd:COG1196    438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKaALLLA 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2186 EEAEKMKSLAEEAGRLSVE--AEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLkaEAEKLQKQKDQAQETAKR 2263
Cdd:COG1196    518 GLRGLAGAVAVLIGVEAAYeaALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFL--PLDKIRARAALAAALARG 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2264 LQEDKQQIQQRLDKETEGFQKSLEA-------ERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQ 2336
Cdd:COG1196    596 AIGAAVDLVASDLREADARYYVLGDtllgrtlVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2337 RTEKHTTEIVVQKL-ETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEK 2415
Cdd:COG1196    676 EAEAELEELAERLAeEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEE 755

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2416 GLLLKREKEVEGEKKRFEKQLE----------DEMKKAKALKDEQERQRKLMEEERKKLQAIMDE 2470
Cdd:COG1196    756 LPEPPDLEELERELERLEREIEalgpvnllaiEEYEELEERYDFLSEQREDLEEARETLEEAIEE 820
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1399-2267 4.48e-22

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 105.82  E-value: 4.48e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSdAEKEAAKQKQRALDDLQKYKMQAE----- 1473
Cdd:pfam02463  197 LQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELL-RDEQEEIESSKQEIEKEEEKLAQVlkenk 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 EAERRMKQAEEEKIRQIRvvEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREE 1553
Cdd:pfam02463  276 EEEKEKKLQEEELKLLAK--EEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREA 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1554 AEQELEiwrqkanealrlrlQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQrkfaEQIAQ 1633
Cdd:pfam02463  354 EEEEEE--------------ELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLL----LELAR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1634 QKLSAEQECIRLKADFEHAEQQRGLLDnelQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSK 1713
Cdd:pfam02463  416 QLEDLLKEEKKEELEILEEEEESIELK---QGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSR 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1714 QLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEaaRQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERL 1793
Cdd:pfam02463  493 QKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHG--RLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRAL 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1794 KRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLqtssDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLES 1873
Cdd:pfam02463  571 TELPLGARKLRLLIPKLKLPLKSIAVLEIDPI----LNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKES 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1874 ELKKLKGIA-DETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQK 1952
Cdd:pfam02463  647 GLRKGVSLEeGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1953 ekaekeaekqvvlaKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEA 2032
Cdd:pfam02463  727 --------------VQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEK 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2033 EKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKqqadAEMSKHKKEAEQALQQKSQVEKELTVVKLQ 2112
Cdd:pfam02463  793 EEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEEL----ALELKEEQKLEKLAEEELERLEEEITKEEL 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2113 LDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMK 2192
Cdd:pfam02463  869 LQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEK 948

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2193 SLAEEAgRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQED 2267
Cdd:pfam02463  949 EKEENN-KEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEF 1022
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1336-2277 7.55e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 105.14  E-value: 7.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1336 ADAEKQKQNIQQELQHL-KSLSDQEIKSKNQQLEDALVSRRKIEEeihiiriQLEKTTAHKAKSEAELQELRDRAAEAEK 1414
Cdd:TIGR02168  209 AEKAERYKELKAELRELeLALLVLRLEELREELEELQEELKEAEE-------ELEELTAELQELEEKLEELRLEVSELEE 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1415 LRKAAQDEAERLRKQVAEETQRKKnaedelkrksdaekEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEkirqirvve 1494
Cdd:TIGR02168  282 EIEELQKELYALANEISRLEQQKQ--------------ILRERLANLERQLEELEAQLEELESKLDELAEE--------- 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1495 evaqksaATQLQTKAMSFSEQTTKLEESLKKEQGnvlKLQEEADKLKKQQKEANTAREEAEQELEiwRQKANEALRLRLQ 1574
Cdd:TIGR02168  339 -------LAELEEKLEELKEELESLEAELEELEA---ELEELESRLEELEEQLETLRSKVAQLEL--QIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1575 AEEEAQKKSHAQEEAEKQKLEaerdakkrgkaEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQ 1654
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELL-----------KKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQ 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1655 QRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMK-INAEKASMVNTEKSKQLLESEALkmkQLADEAARM 1733
Cdd:TIGR02168  476 ALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSgILGVLSELISVDEGYEAAIEAAL---GGRLQAVVV 552

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1734 RSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAEnerlkrQAEEEAyqRKLLEDQAAQ 1813
Cdd:TIGR02168  553 ENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLV------KFDPKL--RKALSYLLGG 624

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1814 HK--QDIEEKITQLqtssdSELGRQKNIVeeTLKQKKV---------VEEEIHII---KINFHKASKEKADLESELKKLK 1879
Cdd:TIGR02168  625 VLvvDDLDNALELA-----KKLRPGYRIV--TLDGDLVrpggvitggSAKTNSSIlerRREIEELEEKIEELEEKIAELE 697

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1880 GIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKea 1959
Cdd:TIGR02168  698 KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEE-- 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1960 ekqvvLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAA 2039
Cdd:TIGR02168  776 -----ELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEEL 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2040 ENEAAKQAKAQNDTEKQRkeaeeeaARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQ 2119
Cdd:TIGR02168  851 SEDIESLAAEIEELEELI-------EELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2120 KVLLDQELQRVKGEVNDAFKQKSqvevelARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLlaeeaekmkslaEEAG 2199
Cdd:TIGR02168  924 LAQLELRLEGLEVRIDNLQERLS------EEYSLTLEEAEALENKIEDDEEEARRRLKRLENKI------------KELG 985

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2200 RLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKlkaeaeklqkqkdqaqETAKRLQEDKQQIQQRLDK 2277
Cdd:TIGR02168  986 PVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDR----------------EARERFKDTFDQVNENFQR 1047
CH_SPTB_like_rpt2 cd21248
second calponin homology (CH) domain found in the beta-I spectrin-like subfamily; The beta-I ...
 111-168 9.94e-22

second calponin homology (CH) domain found in the beta-I spectrin-like subfamily; The beta-I spectrin-like family includes beta-I, -II, -III and -IV spectrins. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. Beta-I spectrin, also called spectrin beta chain, erythrocytic (SPTB), may be involved in anaemia pathogenesis. Beta-II spectrin, also called spectrin beta chain, non-erythrocytic 1 (SPTBN1), or fodrin beta chain, is a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Beta-III spectrin, also called spectrin beta chain, non-erythrocytic 2 (SPTBN2), or spinocerebellar ataxia 5 protein (SCA5), may play a crucial role as a longer actin-membrane cross-linker or fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. Beta-IV spectrin is also called spectrin, non-erythroid beta chain 3 (SPTBN3) or spectrin beta chain, non-erythrocytic 4 (SPTBN4). Its mutation associates with congenital myopathy, neuropathy, and central deafness. Members of this subfamily contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409097  Cd Length: 105  Bit Score: 92.84  E-value: 9.94e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21248     45 PDLIDYDKLSKSNALYNLQNAFNVAEQKLGLTKLLDPEDVNVEQPDEKSIITYVVTYY 102
CH_beta_spectrin_rpt2 cd21194
second calponin homology (CH) domain found in the beta spectrin family; The beta spectrin ...
 111-168 1.90e-21

second calponin homology (CH) domain found in the beta spectrin family; The beta spectrin family includes beta-I, -II, -III, -IV and -V spectrins. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. Beta-I spectrin, also called spectrin beta chain, erythrocytic (SPTB), may be involved in anaemia pathogenesis. Beta-II spectrin, also called spectrin beta chain, non-erythrocytic 1 (SPTBN1), or fodrin beta chain, is a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Beta-IV spectrin is also called spectrin, non-erythroid beta chain 3 (SPTBN3) or spectrin beta chain, non-erythrocytic 4 (SPTBN4). Its mutation associates with congenital myopathy, neuropathy, and central deafness. Beta-III spectrin is also called spectrin beta chain, non-erythrocytic 2 (SPTBN2), or spinocerebellar ataxia 5 protein (SCA5). Beta-V spectrin, also called spectrin beta chain, non-erythrocytic 5 (SPTBN5), is a mammalian ortholog of Drosophila beta H spectrin. Beta-III and Beta-V spectrins may play crucial roles as longer actin-membrane cross-linkers or fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409043  Cd Length: 105  Bit Score: 92.09  E-value: 1.90e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21194     45 PDLIDYNRLDPNDHLGNLNNAFDVAEQELGIAKLLDAEDVDVARPDEKSIMTYVASYY 102
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1430-2336 3.15e-21

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 103.13  E-value: 3.15e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1430 VAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEkirqirvvEEVAQKSAATQLQTka 1509
Cdd:pfam02463  164 GSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKL--------ELEEEYLLYLDYLK-- 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1510 msfsEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEA 1589
Cdd:pfam02463  234 ----LNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRK 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1590 EKQKLEAERDAKKRGKAEEAALKQKENAEkELDKQRKFAEQIAQQKLSAEQECIRLKadfEHAEQQRGLLDNELQRLKNE 1669
Cdd:pfam02463  310 VDDEEKLKESEKEKKKAEKELKKEKEEIE-ELEKELKELEIKREAEEEEEEELEKLQ---EKLEQLEEELLAKKKLESER 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1670 VNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMvNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEE 1749
Cdd:pfam02463  386 LSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLK-EEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDE 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1750 EAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKE-AENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTS 1828
Cdd:pfam02463  465 LELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKEsKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVA 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1829 SDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLK-----GIADETQKSKLKAEEEAEKLKKLA 1903
Cdd:pfam02463  545 ISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAvleidPILNLAQLDKATLEADEDDKRAKV 624

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1904 AEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDV 1983
Cdd:pfam02463  625 VEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKK 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1984 LSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEE 2063
Cdd:pfam02463  705 EQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTE 784

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2064 AARRAAAEAAALKQKQQADAEMSKHKKEAEQALQqksQVEKELTVVKLQLDETDKQKVLLDQELQrvKGEVNDAFKQKSQ 2143
Cdd:pfam02463  785 KLKVEEEKEEKLKAQEEELRALEEELKEEAELLE---EEQLLIEQEEKIKEEELEELALELKEEQ--KLEKLAEEELERL 859

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2144 VEVELARVRIQMEELVKLKLKIEEENRRLMQK-DKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQ 2222
Cdd:pfam02463  860 EEEITKEELLQELLLKEEELEEQKLKDELESKeEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEE 939

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2223 RALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEgfqKSLEAERKRQLEASAEaEK 2302
Cdd:pfam02463  940 LLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEK---ERLEEEKKKLIRAIIE-ET 1015

                          890       900       910
                   ....*....|....*....|....*....|....
gi 1389908296 2303 LKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQ 2336
Cdd:pfam02463 1016 CQRLKEFLELFVSINKGWNKVFFYLELGGSAELR 1049
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 713-779 7.12e-21

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 88.86  E-value: 7.12e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  713 QLKPRNptTPLKGKMPIQAVCDFKQMEITVHRGDECALLNNSNPFKWQVLNDTGSEASVPSICFLVP 779
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2024-2514 7.89e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.55  E-value: 7.89e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2024 LLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVE 2103
Cdd:COG1196    236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2104 KELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRL------MQKDK 2177
Cdd:COG1196    316 ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELaeelleALRAA 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2178 DSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQA 2257
Cdd:COG1196    396 AELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2258 QETAKRLQEDKQQIQQRLD------KETEGFQKSLEAERK---------------------RQLEASAEAEKLKLRVKEL 2310
Cdd:COG1196    476 EAALAELLEELAEAAARLLllleaeADYEGFLEGVKAALLlaglrglagavavligveaayEAALEAALAAALQNIVVED 555

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2311 SLAQTKAEDEAKKFKK------QADEVKAQLQRTEKHTT------------EIVVQKLETQRLQSTREADDLKSAIADLE 2372
Cdd:COG1196    556 DEVAAAAIEYLKAAKAgratflPLDKIRARAALAAALARgaigaavdlvasDLREADARYYVLGDTLLGRTLVAARLEAA 635

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2373 EERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALK--DEQ 2450
Cdd:COG1196    636 LRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAeaEEE 715

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2451 ERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQL 2514
Cdd:COG1196    716 RLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1680-2300 2.96e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 99.63  E-value: 2.96e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1680 LEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAK-------KQRQIAEEEAA 1752
Cdd:COG1196    191 LEDILGELERQLEPLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEaeleeleAELAELEAELE 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1753 RQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQtssdsE 1832
Cdd:COG1196    271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE-----E 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1833 LGRQKNIVEETLKQKKVVEEEIhiikinfHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKE 1912
Cdd:COG1196    346 LEEAEEELEEAEAELAEAEEAL-------LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1913 AEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDvlSKNKEDVL 1992
Cdd:COG1196    419 LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE--AAARLLLL 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1993 AQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAE--------NEAAKQAKAQNDTEKQRKEAEEEA 2064
Cdd:COG1196    497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALaaalqnivVEDDEVAAAAIEYLKAAKAGRATF 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2065 ARRAAAEAAALKQKQQADAEMSKH-------KKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGE---V 2134
Cdd:COG1196    577 LPLDKIRARAALAAALARGAIGAAvdlvasdLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEgegG 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2135 NDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQI 2214
Cdd:COG1196    657 SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREE 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2215 AESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQ-------AQETAKRLQEDKQQIQQRLD------KETEG 2281
Cdd:COG1196    737 LLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlgpvnllAIEEYEELEERYDFLSEQREdleearETLEE 816

                          650
                   ....*....|....*....
gi 1389908296 2282 FQKSLEAERKRQLEASAEA 2300
Cdd:COG1196    817 AIEEIDRETRERFLETFDA 835
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1280-1946 1.17e-19

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 97.73  E-value: 1.17e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1280 KLKEEERRKMAEIQAELDKQKQMA--------EAHAKSVAKAEQEALE--LKMKMKEEASKRQDVAADAEKQKQNIQQEL 1349
Cdd:TIGR00618  159 KAKSKEKKELLMNLFPLDQYTQLAlmefakkkSLHGKAELLTLRSQLLtlCTPCMPDTYHERKQVLEKELKHLREALQQT 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1350 QHLKSLSDQEIKSKNQQLedalvsrrKIEEEIHIIRIQLEKTTAHKAKSEaELQELRDRAAEAEKLrKAAQDEAERLRKQ 1429
Cdd:TIGR00618  239 QQSHAYLTQKREAQEEQL--------KKQQLLKQLRARIEELRAQEAVLE-ETQERINRARKAAPL-AAHIKAVTQIEQQ 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1430 VAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQirvveevAQKSAATQLQTKA 1509
Cdd:TIGR00618  309 AQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIR-------EISCQQHTLTQHI 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1510 MSFSEQTTKLEESLKKEQGNVLKLQEEAdklkkQQKEANTAREEAEQEleiwrQKANEALRLRLQAEEEAQKKSHAQEEA 1589
Cdd:TIGR00618  382 HTLQQQKTTLTQKLQSLCKELDILQREQ-----ATIDTRTSAFRDLQG-----QLAHAKKQQELQQRYAELCAAAITCTA 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1590 EKQKLE--AERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQqkLSAEQECIrLKADFEHAEQQRGLLDN------ 1661
Cdd:TIGR00618  452 QCEKLEkiHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLL--ELQEEPCP-LCGSCIHPNPARQDIDNpgpltr 528

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1662 --------------ELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQmKINAEKASMVNTEKSKQLLESEaLKMKQLA 1727
Cdd:TIGR00618  529 rmqrgeqtyaqletSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQ-CDNRSKEDIPNLQNITVRLQDL-TEKLSEA 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1728 DEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAineatrLKTEAEMALKAKEAENERLKRQAEEEAYQRKLL 1807
Cdd:TIGR00618  607 EDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTA------LHALQLTLTQERVREHALSIRVLPKELLASRQL 680

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1808 EDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQkkvveeeIHIIKINFHKASKEKADLESELKKLKGIADETQK 1887
Cdd:TIGR00618  681 ALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDRE-------FNEIENASSSLGSDLAAREDALNQSLKELMHQAR 753

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1888 SKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRitaaeeEAARQCKAAQEEVERLKKKAE 1946
Cdd:TIGR00618  754 TVLKARTEAHFNNNEEVTAALQTGAELSHLAA------EIQFFNRLREEDTHLLKTLEA 806
CH_SYNE2_rpt2 cd21244
second calponin homology (CH) domain found in synaptic nuclear envelope protein 2 (SYNE-2) and ...
 111-165 4.39e-19

second calponin homology (CH) domain found in synaptic nuclear envelope protein 2 (SYNE-2) and similar proteins; SYNE-2, also called nesprin-2, KASH domain-containing protein 2 (KASH2), nuclear envelope spectrin repeat protein 2, nucleus and actin connecting element protein, or protein NUANCE, is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. SYNE-2 also acts as a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. SYNE-2 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409093  Cd Length: 109  Bit Score: 85.27  E-value: 4.39e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVS 165
Cdd:cd21244     48 PGLVDMEKLKGRSNRENLEEAFRIAEQELKIPRLLEPEDVDVVNPDEKSIMTYVA 102
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2185-2506 5.09e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.77  E-value: 5.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2185 AEEAEKMKSLAEEAGRLsvEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRL 2264
Cdd:COG1196    209 AEKAERYRELKEELKEL--EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEA 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2265 QEDKQQIQQRLDKEtegfQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTE 2344
Cdd:COG1196    287 QAEEYELLAELARL----EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2345 IVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQ-QEQIEQQKAELQQSFLTEKGLLLKREK 2423
Cdd:COG1196    363 AEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLErLERLEEELEELEEALAELEEEEEEEEE 442

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2424 EVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQL 2503
Cdd:COG1196    443 ALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGL 522


                   ...
gi 1389908296 2504 AEE 2506
Cdd:COG1196    523 AGA 525
CH_SPTB_rpt2 cd21319
second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and ...
 111-168 7.71e-19

second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTB, also called beta-I spectrin, may be involved in anaemia pathogenesis. SPTB contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409168  Cd Length: 112  Bit Score: 85.06  E-value: 7.71e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21319     48 PDLVDFGKLKKSNARHNLEHAFNVAERQLGITKLLDPEDVFTENPDEKSIITYVVAFY 105
CH_SYNE-like_rpt2 cd21192
second calponin homology (CH) domain found in the synaptic nuclear envelope protein (SYNE) ...
 111-165 8.37e-19

second calponin homology (CH) domain found in the synaptic nuclear envelope protein (SYNE) family; The SYNE family includes SYNE-1, -2 and calmin. SYNE-1 (also called nesprin-1, enaptin, KASH domain-containing protein 1, KASH1, myocyte nuclear envelope protein 1, MYNE-1, or nuclear envelope spectrin repeat protein 1) and SYNE-2 (also called nesprin-2, KASH domain-containing protein 2, KASH2, nuclear envelope spectrin repeat protein 2, nucleus and actin connecting element protein, or protein NUANCE) may act redundantly. They are multi-isomeric modular proteins which form a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. They also act as components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409041  Cd Length: 107  Bit Score: 84.40  E-value: 8.37e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVS 165
Cdd:cd21192     46 PDLVDMKTVKNRSPRDNLELAFRIAEQHLNIPRLLEVEDVLVDKPDERSIMTYVS 100
CH_DMD-like_rpt2 cd21187
second calponin homology (CH) domain found in the dystrophin family; The dystrophin family ...
 111-172 1.00e-18

second calponin homology (CH) domain found in the dystrophin family; The dystrophin family includes dystrophin and its paralog, utrophin. Dystrophin, encoded by the DMD gene, is a large, submembrane cytoskeletal protein that is the main component of the dystrophin-glycoprotein complex (DGC) in skeletal muscles. It links the transmembrane DGC to the actin cytoskeleton through binding strongly to the cytoplasmic tail of beta-dystroglycan, the transmembrane subunit of a highly O-glycosylated cell-surface protein. Dystrophin is also involved in maintaining the structural integrity of cells, as well as in the formation of the blood-brain barrier (BBB). Utrophin, also called dystrophin-related protein 1 (DRP-1), is an autosomal dystrophin homolog that increases dystrophic muscle function and reduces pathology. It is broadly expressed in both the mRNA and protein levels, and occurs in the cerebrovascular endothelium. Utrophin forms the utrophin-glycoprotein complex (UGC) by interacting with dystroglycans (DGs) and sarcoglycan-dystroglycans, as well as sarcoglycan and sarcospan (SG-SSPN) subcomplexes. It may act as a scaffolding protein that stabilizes lipid microdomains and clusters mechanosensitive channel subunits, and link the F-actin cytoskeleton to the cell membrane via the associated glycoprotein complex. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409036  Cd Length: 104  Bit Score: 84.40  E-value: 1.00e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21187     43 PDLFDFDSLVKDSPESRLEHAFTVAHEHLGIEKLLDPEDVNVEQPDKKSILMYVTSLFQVLP 104
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1266-2363 3.08e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 93.32  E-value: 3.08e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLkEEERRKMAEIQAELDKQKQMAEAhAKSVAKAEQEALELKMK-MKEEASKRQDVAADAEKQKQN 1344
Cdd:pfam01576   79 ELESRLEEEEERSQQL-QNEKKKMQQHIQDLEEQLDEEEA-ARQKLQLEKVTTEAKIKkLEEDILLLEDQNSKLSKERKL 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1345 IQQELQHLKS-LSDQEIKSKNqqledalvsrrkieeeihiiriqlekTTAHKAKSEAELQELRDRAAEAEKLRkaaqdea 1423
Cdd:pfam01576  157 LEERISEFTSnLAEEEEKAKS--------------------------LSKLKNKHEAMISDLEERLKKEEKGR------- 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1424 ERLRKqvaeetqrkknaedeLKRKSDAEkeaAKQKQRALDDLQkykMQAEEAERRMKQAEEE-KIRQIRVVEEVAQKSAA 1502
Cdd:pfam01576  204 QELEK---------------AKRKLEGE---STDLQEQIAELQ---AQIAELRAQLAKKEEElQAALARLEEETAQKNNA 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1503 tqlqtkamsfseqttklEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRlRLQAEEEAQKK 1582
Cdd:pfam01576  263 -----------------LKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLD-TTAAQQELRSK 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1583 SHAQEEAEKQKLEAErdaKKRGKAEEAALKQKENA-----EKELDKQRKFAEQIAQQKLSAEQECIRLKADFE------- 1650
Cdd:pfam01576  325 REQEVTELKKALEEE---TRSHEAQLQEMRQKHTQaleelTEQLEQAKRNKANLEKAKQALESENAELQAELRtlqqakq 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1651 HAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASmVNTEKSKQLLESEALKMKQLADEA 1730
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKN-IKLSKDVSSLESQLQDTQELLQEE 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1731 ARMRsvAEEAKKQRQIAEEEAArqrseaekiLKEKLAAINEATRlktEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQ 1810
Cdd:pfam01576  481 TRQK--LNLSTRLRQLEDERNS---------LQEQLEEEEEAKR---NVERQLSTLQAQLSDMKKKLEEDAGTLEALEEG 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1811 AAQHKQDIEEKITQLQTSSDSelgrqkniVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKL 1890
Cdd:pfam01576  547 KKRLQRELEALTQQLEEKAAA--------YDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISA 618

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1891 KAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLkkkaedankqkekaekeaekqvVLAKEAA 1970
Cdd:pfam01576  619 RYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDL----------------------VSSKDDV 676

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1971 QKCTAAEQKAQDVLSKNKEDVLAQ-EKLRDEF---ENAKklaqeaekakekaekeaalLRQkaeEAEKQKKAAENEAAKQ 2046
Cdd:pfam01576  677 GKNVHELERSKRALEQQVEEMKTQlEELEDELqatEDAK-------------------LRL---EVNMQALKAQFERDLQ 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2047 AKAQNDTEKQRkeaeeeaarraaaeaAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQE 2126
Cdd:pfam01576  735 ARDEQGEEKRR---------------QLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQ 799

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2127 LQRVKGEVNDAfkQKSQVEVELARVRI------------QME-ELVKLK--LKIEEENRRLMQKDKDSTQKLLAEEAEKM 2191
Cdd:pfam01576  800 LKKLQAQMKDL--QRELEEARASRDEIlaqskesekklkNLEaELLQLQedLAASERARRQAQQERDELADEIASGASGK 877

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2192 KSLAEEAGRLSveaeetARQRQIAESNLAEQ---RALAEKILKEKMQAIQEATKLKAEAEKLQKQKD-------QAQETA 2261
Cdd:pfam01576  878 SALQDEKRRLE------ARIAQLEEELEEEQsntELLNDRLRKSTLQVEQLTTELAAERSTSQKSESarqqlerQNKELK 951

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2262 KRLQEDKQQIQQR-------LDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQAD----- 2329
Cdd:pfam01576  952 AKLQEMEGTVKSKfkssiaaLEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEkgnsr 1031

                         1130      1140      1150
                   ....*....|....*....|....*....|....*..
gi 1389908296 2330 --EVKAQLQRTEKHTTEIVVQKLETQR-LQSTREADD 2363
Cdd:pfam01576 1032 mkQLKRQLEEAEEEASRANAARRKLQReLDDATESNE 1068
CH_SPTBN5_rpt2 cd21249
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 5 (SPTBN5) ...
 111-168 4.94e-18

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 5 (SPTBN5) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN5, also called beta-V spectrin, is a mammalian ortholog of Drosophila beta H spectrin that may play a crucial role as a longer actin-membrane cross-linker or to fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. SPTBN5 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409098  Cd Length: 109  Bit Score: 82.60  E-value: 4.94e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21249     47 PDLIDYGSLRPDRPLYNLANAFLVAEQELGISQLLDPEDVAVPHPDERSIMTYVSLYY 104
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1552-2361 7.66e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 92.05  E-value: 7.66e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1552 EEAEQELEIWRQKANEalrLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQI 1631
Cdd:TIGR02169  180 EEVEENIERLDLIIDE---KRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1632 AQQKLSAEQECIRLKADFEHAEQQ-RGLLDNELQRLKNEVNSTEKQRKQLEdelnkvRSEMDSLLQMKINAEKASMVNTE 1710
Cdd:TIGR02169  257 TEEISELEKRLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLE------RSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1711 KSKQLLESEALKmKQLADEAARMRSVAEEAKKqrqiAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMaLKAKEAEN 1790
Cdd:TIGR02169  331 IDKLLAEIEELE-REIEEERKRRDKLTEEYAE----LKEELEDLRAELEEVDKEFAETRDELKDYREKLEK-LKREINEL 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1791 ERLKRQAEEEAYQrklLEDQAAQHKQDI---EEKITQLQTSSDS---ELGRQKNIVEETLKQKKVVEEEIHIIKINFHKA 1864
Cdd:TIGR02169  405 KRELDRLQEELQR---LSEELADLNAAIagiEAKINELEEEKEDkalEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRV 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1865 SKEKADLESELKKLkgiadETQKSKLKAEEE----AEKLKKLAAEEERRRKEAEEKVKR--ITAAEEEAARQCKA----- 1933
Cdd:TIGR02169  482 EKELSKLQRELAEA-----EAQARASEERVRggraVEEVLKASIQGVHGTVAQLGSVGEryATAIEVAAGNRLNNvvved 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1934 ---AQEEVERLK-KKAEDA-----NKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKnkedVLAQEKLRDEFENA 2004
Cdd:TIGR02169  557 davAKEAIELLKrRKAGRAtflplNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEPAFKY----VFGDTLVVEDIEAA 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2005 KKLAQEA-------------------EKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAA 2065
Cdd:TIGR02169  633 RRLMGKYrmvtlegelfeksgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELS 712

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2066 RRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDafkqksqVE 2145
Cdd:TIGR02169  713 DASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALND-------LE 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2146 VELARVRIQmeELVKLKLKIEEENRRLMQKDKDSTQKL----LAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESN--L 2219
Cdd:TIGR02169  786 ARLSHSRIP--EIQAELSKLEEEVSRIEARLREIEQKLnrltLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNgkK 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2220 AEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQ------KSLEAERKRQ 2293
Cdd:TIGR02169  864 EELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEaleeelSEIEDPKGED 943

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2294 LEASAE---AEKLKLRVKELSLA-------QTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIV--VQKLETQRLQSTREA 2361
Cdd:TIGR02169  944 EEIPEEelsLEDVQAELQRVEEEiralepvNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILerIEEYEKKKREVFMEA 1023
growth_prot_Scy NF041483
polarized growth protein Scy;
1520-2481 1.45e-17

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 91.04  E-value: 1.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALR------------LRLQAEeeaQKKSHAQE 1587
Cdd:NF041483     7 QESHRADDDHLSRFEAEMDRLKTEREKAVQHAEDLGYQVEVLRAKLHEARRslasrpaydgadIGYQAE---QLLRNAQI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1588 EAEKQKLEAERdakkrgkaeeaalkqkenaekELDKQRKFAEQIAQqklsaeqecirlkadfEHAEQQrglldnelQRLK 1667
Cdd:NF041483    84 QADQLRADAER---------------------ELRDARAQTQRILQ----------------EHAEHQ--------ARLQ 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1668 NEVNSTEKQRKQ-LEDELNKVRSEMDSLLQMKIN-AEKASMVNTEKSKQLL-ESEALKMKQLADEAARMRSVAEEAKkQR 1744
Cdd:NF041483   119 AELHTEAVQRRQqLDQELAERRQTVESHVNENVAwAEQLRARTESQARRLLdESRAEAEQALAAARAEAERLAEEAR-QR 197

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1745 QIAEEEAARqrSEAEKILK------EKL--AAINEATRLKTEAEMALKAKEAENERLKRQAEEeayqrklLEDQAAQHKQ 1816
Cdd:NF041483   198 LGSEAESAR--AEAEAILRrarkdaERLlnAASTQAQEATDHAEQLRSSTAAESDQARRQAAE-------LSRAAEQRMQ 268

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1817 DIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEihiikiNFHKASKEKADLESE-LKKLKGIADETQKSKLKAEEE 1895
Cdd:NF041483   269 EAEEALREARAEAEKVVAEAKEAAAKQLASAESANEQ------RTRTAKEEIARLVGEaTKEAEALKAEAEQALADARAE 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1896 AEKLkklaaeeerrrKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAekeaekqvvlAKEAAQKCTA 1975
Cdd:NF041483   343 AEKL-----------VAEAAEKARTVAAEDTAAQLAKAARTAEEVLTKASEDAKATTRAA----------AEEAERIRRE 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1976 AEQKAqDVLSKNKEDVLAQEK---LRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQND 2052
Cdd:NF041483   402 AEAEA-DRLRGEAADQAEQLKgaaKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQIEEAAR 480

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2053 TEKQrkeaeeeaarraaaeaaaLKQKQQADAEMSKHKKEAEQALQQKSQVEKElTVVKLQLDETdkqkvlldqeLQRVKG 2132
Cdd:NF041483   481 TAEE------------------LLTKAKADADELRSTATAESERVRTEAIERA-TTLRRQAEET----------LERTRA 531

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2133 EvndAFKQKSQVEVELARVRIQMEELVKlklKIEEENRRLMQkdkdstqkllAEEAEKmkslAEEAGRLSVEAEEtarQR 2212
Cdd:NF041483   532 E---AERLRAEAEEQAEEVRAAAERAAR---ELREETERAIA----------ARQAEA----AEELTRLHTEAEE---RL 588

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2213 QIAESNLAEQRALAEKILKEkmqAIQEATKLKAEA-EKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFqksleAERK 2291
Cdd:NF041483   589 TAAEEALADARAEAERIRRE---AAEETERLRTEAaERIRTLQAQAEQEAERLRTEAAADASAARAEGENV-----AVRL 660

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2292 RQlEASAEAEKLKLRVKEL-----SLAQTKAE---DEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADD 2363
Cdd:NF041483   661 RS-EAAAEAERLKSEAQESadrvrAEAAAAAErvgTEAAEALAAAQEEAARRRREAEETLGSARAEADQERERAREQSEE 739

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2364 -LKSAIADLEEERKKLKKEAEELQRKSKEMANAqQEQIEQQKAElqqsflTEKGLLLKREKEVEGEKKRFEKQLEDEMKK 2442
Cdd:NF041483   740 lLASARKRVEEAQAEAQRLVEEADRRATELVSA-AEQTAQQVRD------SVAGLQEQAEEEIAGLRSAAEHAAERTRTE 812

                          970       980       990
                   ....*....|....*....|....*....|....*....
gi 1389908296 2443 AkalKDEQERQRKLMEEERKKLQaimDEAVRKQKEAEEE 2481
Cdd:NF041483   813 A---QEEADRVRSDAYAERERAS---EDANRLRREAQEE 845
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1253-1902 1.46e-17

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 91.00  E-value: 1.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1253 LMTLTNQYIKFIIDAQRRLEDDEKAS---EKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEAS 1329
Cdd:pfam01576  178 LSKLKNKHEAMISDLEERLKKEEKGRqelEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETA 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1330 KRqdvaadAEKQKQNiqQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTahkaKSEAELQELRD-R 1408
Cdd:pfam01576  258 QK------NNALKKI--RELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTL----DTTAAQQELRSkR 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1409 AAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELkrksdaeKEAAKQKQRALDDLQKYKmQAEEAERRMKQAEEEKIR 1488
Cdd:pfam01576  326 EQEVTELKKALEEETRSHEAQLQEMRQKHTQALEEL-------TEQLEQAKRNKANLEKAK-QALESENAELQAELRTLQ 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1489 QIRVVEEVAQKSAATQLQTKAMSFSE---QTTKLEESLKKEQG---NVLKLQEEAD-KLKKQQKEANTAREEAE--QEL- 1558
Cdd:pfam01576  398 QAKQDSEHKRKKLEGQLQELQARLSEserQRAELAEKLSKLQSeleSVSSLLNEAEgKNIKLSKDVSSLESQLQdtQELl 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1559 -EIWRQKANEALRLRlQAEEEAQKKSHAQEEAEKQKLEAERdakkrgkaeeaalkQKENAEKELDKQRKFAEQIAQQKLS 1637
Cdd:pfam01576  478 qEETRQKLNLSTRLR-QLEDERNSLQEQLEEEEEAKRNVER--------------QLSTLQAQLSDMKKKLEEDAGTLEA 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1638 AEQECIRLKADFEHAEQQrglldneLQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKasmvNTEKSKQLLE 1717
Cdd:pfam01576  543 LEEGKKRLQRELEALTQQ-------LEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEK----KQKKFDQMLA 611

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1718 SEALKMKQLADEAARMRSVAEEaKKQRQI----AEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERL 1793
Cdd:pfam01576  612 EEKAISARYAEERDRAEAEARE-KETRALslarALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRAL 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1794 KRQAEEEAYQRKLLED--QAAQH-KQDIEEKITQLQTSSDSELGRQKNIVEET----LKQKKVVEEEIHIIKINFHKASK 1866
Cdd:pfam01576  691 EQQVEEMKTQLEELEDelQATEDaKLRLEVNMQALKAQFERDLQARDEQGEEKrrqlVKQVRELEAELEDERKQRAQAVA 770

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1389908296 1867 EKADLESELKKLKGIADETQKSKlkaEEEAEKLKKL 1902
Cdd:pfam01576  771 AKKKLELDLKELEAQIDAANKGR---EEAVKQLKKL 803
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1194-1881 2.79e-17

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 90.03  E-value: 2.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1194 DCHKNAKAYIDSVKDyEFQILTYKALQDPIASPLKKPKMEcasddiiQEYVNLRTRYSELMTLTNQYIKFIIDAQRRLED 1273
Cdd:TIGR00618  187 AKKKSLHGKAELLTL-RSQLLTLCTPCMPDTYHERKQVLE-------KELKHLREALQQTQQSHAYLTQKREAQEEQLKK 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1274 DEKASEKLKEEER-----RKMAEIQAELDKQKQMAE--AHAKSVAKAEQEAL----ELKMKMKEEASKRQDVAAdAEKQK 1342
Cdd:TIGR00618  259 QQLLKQLRARIEElraqeAVLEETQERINRARKAAPlaAHIKAVTQIEQQAQrihtELQSKMRSRAKLLMKRAA-HVKQQ 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSLSDQEIKSKNQQLEDALV----SRRKIEEEIHIIRIQ---------------LEKTTAHKAKSEAELQ 1403
Cdd:TIGR00618  338 SSIEEQRRLLQTLHSQEIHIRDAHEVATSIreisCQQHTLTQHIHTLQQqkttltqklqslckeLDILQREQATIDTRTS 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1404 ELRD---RAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAE---DELKRKSDAEKEAAKQKQRALddLQKYKMQAEEAER 1477
Cdd:TIGR00618  418 AFRDlqgQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKihlQESAQSLKEREQQLQTKEQIH--LQETRKKAVVLAR 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1478 RMKQAEEEKI--RQIRVVEEVAQKSAATQLQTKAMSFSEQT-TKLEESLKKEQGNVLKLQEEADKLKKQQKEAntarEEA 1554
Cdd:TIGR00618  496 LLELQEEPCPlcGSCIHPNPARQDIDNPGPLTRRMQRGEQTyAQLETSEEDVYHQLTSERKQRASLKEQMQEI----QQS 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1555 EQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERdAKKRGKAEEAALKQK----ENAEKELdKQRKFAEQ 1630
Cdd:TIGR00618  572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQH-ALLRKLQPEQDLQDVrlhlQQCSQEL-ALKLTALH 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1631 IAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMV-NT 1709
Cdd:TIGR00618  650 ALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENAsSS 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1710 EKSKQLLESEAL-----KMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRL--KTEAEMA 1782
Cdd:TIGR00618  730 LGSDLAAREDALnqslkELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLlkTLEAEIG 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1783 LKAKEAENERLKRQaeeeayqrKLLEDQAAQHKQDIEEKITQLqtssdSELGRQKNIVEETLKQkkvveeeihiikinFH 1862
Cdd:TIGR00618  810 QEIPSDEDILNLQC--------ETLVQEEEQFLSRLEEKSATL-----GEITHQLLKYEECSKQ--------------LA 862

                          730
                   ....*....|....*....
gi 1389908296 1863 KASKEKADLESELKKLKGI 1881
Cdd:TIGR00618  863 QLTQEQAKIIQLSDKLNGI 881
CH_SPTBN2_rpt2 cd21321
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) ...
 111-168 2.86e-17

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN2, also called beta-III spectrin, or spinocerebellar ataxia 5 protein (SCA5), probably plays an important role in the neuronal membrane skeleton. Mutations in SPTBN2 is associated with spinocerebellar ataxia type 5. SPTBN2 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409170  Cd Length: 119  Bit Score: 80.49  E-value: 2.86e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21321     48 PDLIDFETLKKSNAHYNLQNAFNVAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYY 105
CH_DMD_rpt2 cd21233
second calponin homology (CH) domain found in dystrophin and similar proteins; Dystrophin, ...
 111-173 8.37e-17

second calponin homology (CH) domain found in dystrophin and similar proteins; Dystrophin, encoded by the DMD gene, is a large, submembrane cytoskeletal protein that is the main component of the dystrophin-glycoprotein complex (DGC) in skeletal muscles. It links the transmembrane DGC to the actin cytoskeleton through binding strongly to the cytoplasmic tail of beta-dystroglycan, the transmembrane subunit of a highly O-glycosylated cell-surface protein. It is involved in maintaining the structural integrity of cells, as well as in the formation of the blood-brain barrier (BBB). Mutations in dystrophin lead to Duchenne muscular dystrophy (DMD). Moreover, dystrophin deficiency is associated with abnormal cerebral diffusion and perfusion, as well as in acute Trypanosoma cruzi infection. The dystrophin subfamily has been characterized by a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, dystrophin contains two syntrophin binding sites (SBSs) and a long N-terminal extension that comprises two actin-binding calponin homology (CH) domains, approximately 24 spectrin repeats (SRs) and a WW domain. The model corresponds to the second CH domain.


Pssm-ID: 409082  Cd Length: 111  Bit Score: 79.20  E-value: 8.37e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296  111 PALIDMNQVYRQSNQ-ENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMPR 173
Cdd:cd21233     43 PDLFDWNSVVSQQSAtERLDHAFNIARQHLGIEKLLDPEDVATAHPDKKSILMYVTSLFQVLPQ 106
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1026-1901 3.37e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.65  E-value: 3.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1026 ADAEETLKNYEARLRDVSKVPSeQKEVEKHRSQMKSMRSEAEADQVMFDRLQDDLRKATTVHDKMTRIHSERDADLEHYR 1105
Cdd:TIGR02168  209 AEKAERYKELKAELRELELALL-VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1106 QLVNGLLERWQAVFAQIELRLREldllgrhMNSYRDSYEWLIRWLTEARQRQEKiqavpisdsraLREQLTDEKKLLGEI 1185
Cdd:TIGR02168  288 KELYALANEISRLEQQKQILRER-------LANLERQLEELEAQLEELESKLDE-----------LAEELAELEEKLEEL 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1186 EKNKDKIDDCHKNAKAyidsvkdyefqiltykalqdpiasplKKPKMECASDDIIQEYVNLRTRYSELMTLTNQYIKFII 1265
Cdd:TIGR02168  350 KEELESLEAELEELEA--------------------------ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEE--------ERRKMAEIQAELDKQKQMAEAHAKSVAKAEqEALELKMKMKEEASKRQDvaaD 1337
Cdd:TIGR02168  404 RLEARLERLEDRRERLQQEieellkklEEAELKELQAELEELEEELEELQEELERLE-EALEELREELEEAEQALD---A 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1338 AEKQKQNIQQELQHLKSLsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTA--HKAKSEA---ELQELRDRAAEA 1412
Cdd:TIGR02168  480 AERELAQLQARLDSLERL--QENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEgyEAAIEAAlggRLQAVVVENLNA 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1413 EKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAkqkQRALDDLQKYKMQAEEAERRMKQaeeekirQIRV 1492
Cdd:TIGR02168  558 AKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGF---LGVAKDLVKFDPKLRKALSYLLG-------GVLV 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1493 VEEVAQksaATQLQtKAMSFSEQTTKLEESLKKEQGNVLklqeeadklkKQQKEANTAREEAEQELEIWRQKANEalrlr 1572
Cdd:TIGR02168  628 VDDLDN---ALELA-KKLRPGYRIVTLDGDLVRPGGVIT----------GGSAKTNSSILERRREIEELEEKIEE----- 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1573 lqAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHA 1652
Cdd:TIGR02168  689 --LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEL 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1653 EQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSlLQMKINAEKASMVNTEKSKQLLESEalkmkqlADEAAR 1732
Cdd:TIGR02168  767 EERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDE-LRAELTLLNEEAANLRERLESLERR-------IAATER 838

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1733 MRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAA 1812
Cdd:TIGR02168  839 RLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELE 918

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1813 QHKQDIEEKITQLQTssdSELGRQKNIveETLKQKKVVEEEIHIIKINFHKASKEKAdlESELKKLKGIADETQKSKLKA 1892
Cdd:TIGR02168  919 ELREKLAQLELRLEG---LEVRIDNLQ--ERLSEEYSLTLEEAEALENKIEDDEEEA--RRRLKRLENKIKELGPVNLAA 991


                   ....*....
gi 1389908296 1893 EEEAEKLKK 1901
Cdd:TIGR02168  992 IEEYEELKE 1000
CH_UTRN_rpt2 cd21234
second calponin homology (CH) domain found in utrophin and similar proteins; Utrophin, also ...
 111-172 5.86e-16

second calponin homology (CH) domain found in utrophin and similar proteins; Utrophin, also called dystrophin-related protein 1 (DRP-1), is an autosomal dystrophin homolog that increases dystrophic muscle function and reduces pathology. It is broadly expressed in both the mRNA and protein levels, and occurs in the cerebrovascular endothelium. Utrophin forms the utrophin-glycoprotein complex (UGC) by interacting with dystroglycans (DGs) and sarcoglycan-dystroglycans, as well as sarcoglycan and sarcospan (SG-SSPN) subcomplexes. It may act as a scaffolding protein that stabilizes lipid microdomains and clusters mechanosensitive channel subunits, and link the F-actin cytoskeleton to the cell membrane via the associated glycoprotein complex. Like dystrophin, utrophin has a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, it contains two syntrophin binding sites (SBSs) and a long N-terminal extension that comprises two actin-binding calponin homology (CH) domains, up to 24 spectrin repeats (SRs), and a WW domain. However, utrophin lacks the intrinsic microtubule binding activity of dystrophin SRs. This model corresponds to the second CH domain.


Pssm-ID: 409083 [Multi-domain]  Cd Length: 104  Bit Score: 76.53  E-value: 5.86e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21234     43 PDLFSWDKVVKMSPVERLEHAFSKAKNHLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLP 104
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2080-2494 6.93e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 85.50  E-value: 6.93e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2080 QADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLD--ETDKQKVLLDQELQRVKGEV---------NDAFKQKSQVEVEL 2148
Cdd:TIGR02169  167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLErlRREREKAERYQALLKEKREYegyellkekEALERQKEAIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2149 ARVRiqmEELVKLKLKIEEENRRLMQKdkdstQKLLAEEAEKMKSLAEEagrlsveaeetarqrqiaesnlaEQRALAEK 2228
Cdd:TIGR02169  247 ASLE---EELEKLTEEISELEKRLEEI-----EQLLEELNKKIKDLGEE-----------------------EQLRVKEK 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2229 ILKekmqaiqeatkLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDK---ETEGFQKSLEAERKRQLEASAEAEKLKl 2305
Cdd:TIGR02169  296 IGE-----------LEAEIASLERSIAEKERELEDAEERLAKLEAEIDKllaEIEELEREIEEERKRRDKLTEEYAELK- 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2306 rvKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQStrEADDLKSAIADleeerkklkkeaeel 2385
Cdd:TIGR02169  364 --EELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQE--ELQRLSEELAD--------------- 424

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2386 qrkskemANAQQEQIEQQKAELQqsflTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERqrklMEEERKKLQ 2465
Cdd:TIGR02169  425 -------LNAAIAGIEAKINELE----EEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDR----VEKELSKLQ 489

                          410       420
                   ....*....|....*....|....*....
gi 1389908296 2466 AIMDEAVRKQKEAEEEMKNKQREMDVLDK 2494
Cdd:TIGR02169  490 RELAEAEAQARASEERVRGGRAVEEVLKA 518
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1276-1941 1.20e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 84.73  E-value: 1.20e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1276 KASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQdvaadaekqkQNIQQELQHLKS- 1354
Cdd:TIGR02169  233 EALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQ----------LRVKEKIGELEAe 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1355 --LSDQEIKSKNQQLEDALVSRRKieeeihiIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAE 1432
Cdd:TIGR02169  303 iaSLERSIAEKERELEDAEERLAK-------LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEE 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1433 ETQRKKNAEDELK---RKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVaqksaatqLQTKA 1509
Cdd:TIGR02169  376 VDKEFAETRDELKdyrEKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEE--------KEDKA 447

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1510 MSFSEQTTKLE---ESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRL------------- 1573
Cdd:TIGR02169  448 LEIKKQEWKLEqlaADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEvlkasiqgvhgtv 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1574 ----QAEEEAQKkshAQEEAEKQKLEA-----ERDAK------KRGKAEEAA---LKQKENAEKELDKQRK--------- 1626
Cdd:TIGR02169  528 aqlgSVGERYAT---AIEVAAGNRLNNvvvedDAVAKeaiellKRRKAGRATflpLNKMRDERRDLSILSEdgvigfavd 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1627 ---FAEQIAqqklSAEQECIRLKADFEHAEQQRGLLDN------------------------------------ELQRLK 1667
Cdd:TIGR02169  605 lveFDPKYE----PAFKYVFGDTLVVEDIEAARRLMGKyrmvtlegelfeksgamtggsraprggilfsrsepaELQRLR 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1668 NEVNSTEKQRKQLEDELNKVRSEMDSLLQmKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAK------ 1741
Cdd:TIGR02169  681 ERLEGLKRELSSLQSELRRIENRLDELSQ-ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIenvkse 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1742 ----------KQRQIAEEEAAR---QRSEAEKILKEKLAAIN--EATRLKTEA-----EMALKAKEAENERLKRQAEEEA 1801
Cdd:TIGR02169  760 lkelearieeLEEDLHKLEEALndlEARLSHSRIPEIQAELSklEEEVSRIEArlreiEQKLNRLTLEKEYLEKEIQELQ 839

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1802 YQRKLLEDQAAQHKQDIEEKITQLQtSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGI 1881
Cdd:TIGR02169  840 EQRIDLKEQIKSIEKEIENLNGKKE-ELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKR 918

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1882 ADETqksKLKAEEEAEKLKKLAAEEERRRKEAEEkvkriTAAEEEAARQCKAAQEEVERL 1941
Cdd:TIGR02169  919 LSEL---KAKLEALEEELSEIEDPKGEDEEIPEE-----ELSLEDVQAELQRVEEEIRAL 970
CH_CLMN_rpt2 cd21245
second calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called ...
 111-172 1.20e-15

second calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Calmin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409094  Cd Length: 106  Bit Score: 75.60  E-value: 1.20e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVMP 172
Cdd:cd21245     45 PSLVDMRQALEKSPRENLEDAFRIAQESLGIPPLLEPEDVMVDSPDEQSIMTYVAQFLEHFP 106
CH_ACTN_rpt2 cd21216
second calponin homology (CH) domain found in the alpha-actinin family; The alpha-actinin ...
 111-168 1.30e-15

second calponin homology (CH) domain found in the alpha-actinin family; The alpha-actinin (ACTN) family includes alpha-actinin-1, -2, -3, and -4. They are F-actin cross-linking proteins which are thought to anchor actin to a variety of intracellular structures. ACTN1 mutations cause congenital macrothrombocytopenia. ACTN2 mutations are associated with cardiomyopathies, as well as skeletal muscle disorder. ACTN3 is critical in anchoring the myofibrillar actin filaments and plays a key role in muscle contraction. ACTN4 is associated with cell motility and cancer invasion. It is probably involved in vesicular trafficking via its association with the CART complex, which is necessary for efficient transferrin receptor recycling but not for epidermal growth factor receptor (EGFR) degradation. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409065  Cd Length: 115  Bit Score: 75.86  E-value: 1.30e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21216     53 PDLLDYDKLRKDDPRENLNLAFDVAEKHLDIPKMLDAEDiVNTPRPDERSVMTYVSCYY 111
CH_SPTBN4_rpt2 cd21322
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 4 (SPTBN4) ...
 111-168 1.99e-15

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 4 (SPTBN4) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN4, also called beta-IV spectrin, or spectrin, non-erythroid beta chain 3 (SPTBN3), is a novel spectrin isolated as an interactor of the receptor tyrosine phosphatase-like protein ICA512. Its mutation associates with congenital myopathy, neuropathy, and central deafness. SPTBN4 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409171  Cd Length: 130  Bit Score: 75.86  E-value: 1.99e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21322     60 PDLIDFSKLTKSNATYNLQQAFNTAEQHLGLTKLLDPEDVNMEAPDEKSIITYVVSFY 117
CH_SPTBN1_rpt2 cd21320
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) ...
 111-168 2.32e-15

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN1, also called beta-II spectrin, fodrin beta chain, or spectrin, non-erythroid beta chain 1, is also a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. SPTBN1 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409169  Cd Length: 108  Bit Score: 74.75  E-value: 2.32e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLY 168
Cdd:cd21320     45 PDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYY 102
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1480-2527 2.37e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 83.69  E-value: 2.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1480 KQAEE--EKIRQIRVVEEVAQKSAA--TQLQTKAMSFSEQTTKLEESLKKEQgnvlKLQEEADKL------KKQQKEANT 1549
Cdd:pfam01576    2 RQEEEmqAKEEELQKVKERQQKAESelKELEKKHQQLCEEKNALQEQLQAET----ELCAEAEEMrarlaaRKQELEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1550 AREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAER-DAKKRGKAEEAALKQKENAEKELDKQRKFA 1628
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKvTTEAKIKKLEEDILLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1629 EQ-IAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNS---TEKQRKQLEDELNKVRSEMdslLQMKINAEKA 1704
Cdd:pfam01576  158 EErISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGrqeLEKAKRKLEGESTDLQEQI---AELQAQIAEL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1705 SMVNTEKSKQLLESEALKMKQLADEAARMRSVAEeakKQRQIAE--EEAARQRSEAEKILKEKLAAINEATRLKTEAEMA 1782
Cdd:pfam01576  235 RAQLAKKEEELQAALARLEEETAQKNNALKKIRE---LEAQISElqEDLESERAARNKAEKQRRDLGEELEALKTELEDT 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1783 LKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEkITQLQTSSDSELGRQkniVEETLKQKKVVEEEIHIIKinfh 1862
Cdd:pfam01576  312 LDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQE-MRQKHTQALEELTEQ---LEQAKRNKANLEKAKQALE---- 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1863 kasKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRItaaeeeaarqckaaQEEVERLK 1942
Cdd:pfam01576  384 ---SENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKL--------------QSELESVS 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1943 KKAEDANKQKEKaekeaekqvvLAKEAAQkctaAEQKAQDVLSknkedvLAQEKLRDEFENAKKLAQEAEKAKEkaekea 2022
Cdd:pfam01576  447 SLLNEAEGKNIK----------LSKDVSS----LESQLQDTQE------LLQEETRQKLNLSTRLRQLEDERNS------ 500

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2023 alLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQV 2102
Cdd:pfam01576  501 --LQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRL 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2103 EKELTVVKLQLDET-------DKQKVLLDQELQRVKGEVNDAFKQKSQVEVElARVRiqmeELVKLKLKIEEENRRLMQK 2175
Cdd:pfam01576  579 QQELDDLLVDLDHQrqlvsnlEKKQKKFDQMLAEEKAISARYAEERDRAEAE-AREK----ETRALSLARALEEALEAKE 653

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2176 DKDSTQKLLAEEAEKMKSLAEEAGRlsvEAEETARQRQIAESNLAEQRALAEKiLKEKMQAIQEAtKLKAEAeKLQKQKD 2255
Cdd:pfam01576  654 ELERTNKQLRAEMEDLVSSKDDVGK---NVHELERSKRALEQQVEEMKTQLEE-LEDELQATEDA-KLRLEV-NMQALKA 727

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2256 QAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSL---AQTKAEDEA----KKFKKQA 2328
Cdd:pfam01576  728 QFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAqidAANKGREEAvkqlKKLQAQM 807

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2329 DEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLksaiadleeerkklkkeaeelqRKSKEMANA--QQEQIEQQKAE 2406
Cdd:pfam01576  808 KDLQRELEEARASRDEILAQSKESEKKLKNLEAELL----------------------QLQEDLAASerARRQAQQERDE 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2407 LQQ---SFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEE-------ERKKLQAimDEAVRKQK 2476
Cdd:pfam01576  866 LADeiaSGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQlttelaaERSTSQK--SESARQQL 943

                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2477 EAE-EEMKNKQREMDVLDKKRLEQ-----EKQLAEENKKLREQLQTFEISSKTVSQT 2527
Cdd:pfam01576  944 ERQnKELKAKLQEMEGTVKSKFKSsiaalEAKIAQLEEQLEQESRERQAANKLVRRT 1000
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1410-2106 3.11e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 83.48  E-value: 3.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1410 AEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAA------KQKQRALDDLQKYKMQAEEAERRMKQAE 1483
Cdd:TIGR00618  194 GKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQqshaylTQKREAQEEQLKKQQLLKQLRARIEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1484 ---------EEKIRQIRVVEEVAQKSAAT-----QLQTKAMSFSEQTTKLEESLKKEQGNV---LKLQEEADKLKKQQKE 1546
Cdd:TIGR00618  274 aqeavleetQERINRARKAAPLAAHIKAVtqieqQAQRIHTELQSKMRSRAKLLMKRAAHVkqqSSIEEQRRLLQTLHSQ 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1547 ANTAREEAEQELeIWRQKANEALRLRLQAEEEAQKKSHA------------QEEAEKQKLEAERDAKKRGKAEEAALKQK 1614
Cdd:TIGR00618  354 EIHIRDAHEVAT-SIREISCQQHTLTQHIHTLQQQKTTLtqklqslckeldILQREQATIDTRTSAFRDLQGQLAHAKKQ 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1615 ENAEKE-LDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKnEVNSTEKQRKQLEDELNKVRSEMDS 1693
Cdd:TIGR00618  433 QELQQRyAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQET-RKKAVVLARLLELQEEPCPLCGSCI 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1694 LLQMKINAEKASMVNTEKSKQLLEsealKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEAT 1773
Cdd:TIGR00618  512 HPNPARQDIDNPGPLTRRMQRGEQ----TYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIP 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1774 RLKTEAEMALKAKEAENERLKRQAEEEayQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQkkvvEEE 1853
Cdd:TIGR00618  588 NLQNITVRLQDLTEKLSEAEDMLACEQ--HALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQE----RVR 661

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1854 IHIIKINFHKASK------EKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEA 1927
Cdd:TIGR00618  662 EHALSIRVLPKELlasrqlALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDAL 741

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1928 ARQCKAAQEEverlkkkaedankqkekaekeaekqvvlAKEAAQKCTAAEQkaqdvlsKNKEDVLAQEKLRDEFENakkL 2007
Cdd:TIGR00618  742 NQSLKELMHQ----------------------------ARTVLKARTEAHF-------NNNEEVTAALQTGAELSH---L 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2008 AQEAEKAKEKAEKEAALLRQKaeEAEKQKKAAENEAAKQakAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSK 2087
Cdd:TIGR00618  784 AAEIQFFNRLREEDTHLLKTL--EAEIGQEIPSDEDILN--LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSK 859

                          730
                   ....*....|....*....
gi 1389908296 2088 HKKEAEQALQQKSQVEKEL 2106
Cdd:TIGR00618  860 QLAQLTQEQAKIIQLSDKL 878
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1273-1697 3.57e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 83.17  E-value: 3.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1273 DDEKASEKLKEEERRKmAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHL 1352
Cdd:PRK02224   308 DAEAVEARREELEDRD-EELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEI 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1353 KSLsDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQ------------ 1420
Cdd:PRK02224   387 EEL-EEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecgqpvegsp 465

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1421 --DEAERLRKQVAEETQRKKNAEDELKRKsDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVaq 1498
Cdd:PRK02224   466 hvETIEEDRERVEELEAELEDLEEEVEEV-EERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEEL-- 542

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1499 KSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANT------AREEAEQELEIWRQkanealRLR 1572
Cdd:PRK02224   543 RERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERirtllaAIADAEDEIERLRE------KRE 616

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1573 LQAEEEAQKKSHAQEEAE-KQKLEAERDakkrGKAEEAALKQKENAEKELDKqrkfaeqiaqqklsAEQECIRLKADFEH 1651
Cdd:PRK02224   617 ALAELNDERRERLAEKRErKRELEAEFD----EARIEEAREDKERAEEYLEQ--------------VEEKLDELREERDD 678

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1389908296 1652 AEQQRGLLDNELQRLknevNSTEKQRKQLE---DELNKVRSEMDSLLQM 1697
Cdd:PRK02224   679 LQAEIGAVENELEEL----EELRERREALEnrvEALEALYDEAEELESM 723
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1708-2472 3.62e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 83.09  E-value: 3.62e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1708 NTEKSKQLLEsEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKE 1787
Cdd:TIGR00618  161 KSKEKKELLM-NLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQ 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1788 AENERLkRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLqtssdSELGRQKNIVEETLKQKKVVEEEIHIIKINFhKASKE 1867
Cdd:TIGR00618  240 QSHAYL-TQKREAQEEQLKKQQLLKQLRARIEELRAQE-----AVLEETQERINRARKAAPLAAHIKAVTQIEQ-QAQRI 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1868 KADLESELKKLKGIADETQKSkLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQckaaQEEVERLKKKAED 1947
Cdd:TIGR00618  313 HTELQSKMRSRAKLLMKRAAH-VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQ----HTLTQHIHTLQQQ 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1948 ANKQKEKAEKEAEKQVVLAKEAAQkcTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQ 2027
Cdd:TIGR00618  388 KTTLTQKLQSLCKELDILQREQAT--IDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESA 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2028 KAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELT 2107
Cdd:TIGR00618  466 QSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEE 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2108 VVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVEL-------ARVRIQMEELVKLKLKIEEENRRLMQK--DKD 2178
Cdd:TIGR00618  546 DVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIpnlqnitVRLQDLTEKLSEAEDMLACEQHALLRKlqPEQ 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2179 STQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQ--------IAESNLAEQRALAEKILKEKMQAI--------QEATK 2242
Cdd:TIGR00618  626 DLQDVRLHLQQCSQELALKLTALHALQLTLTQERVrehalsirVLPKELLASRQLALQKMQSEKEQLtywkemlaQCQTL 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2243 LKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEgFQKSLEAERKRQLEASAEAEK---LKLRVKELSLAQ-TKAE 2318
Cdd:TIGR00618  706 LRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ-SLKELMHQARTVLKARTEAHFnnnEEVTAALQTGAElSHLA 784

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2319 DEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSaiADLEEERKKLKKEAEELQRKSKEMANAQQE 2398
Cdd:TIGR00618  785 AEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQ--FLSRLEEKSATLGEITHQLLKYEECSKQLA 862

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2399 QIEQQKAELQQsflTEKGLLLKREKEVEGEKKRFEKQLEDEM-KKAKALKDEQERQ---RKLMEEERKKLQAIMDEAV 2472
Cdd:TIGR00618  863 QLTQEQAKIIQ---LSDKLNGINQIKIQFDGDALIKFLHEITlYANVRLANQSEGRfhgRYADSHVNARKYQGLALLV 937
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1450-2469 4.00e-15

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 83.17  E-value: 4.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1450 AEKEAAKQKQRALDDLQKYkMQAEEAERRMKQAEEEKIRQIRVveevaQKSAATQLQTKAMSFSEQTTKLEESLKKEQGN 1529
Cdd:TIGR00606  166 SEGKALKQKFDEIFSATRY-IKALETLRQVRQTQGQKVQEHQM-----ELKYLKQYKEKACEIRDQITSKEAQLESSREI 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1530 VLKLQEEADKLKKQQKEANTARE---EAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEaEKQKLEAERDAKKRGKA 1606
Cdd:TIGR00606  240 VKSYENELDPLKNRLKEIEHNLSkimKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDE-QLNDLYHNHQRTVREKE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1607 EEAALKQKE----NAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEV-------NSTEK 1675
Cdd:TIGR00606  319 RELVDCQREleklNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPfserqikNFHTL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1676 QRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKK----QRQIAEEEA 1751
Cdd:TIGR00606  399 VIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQlegsSDRILELDQ 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1752 ARQRSEAEKILKEKlaaiNEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQhkqdiEEKITQLQTSSDS 1831
Cdd:TIGR00606  479 ELRKAERELSKAEK----NSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQ-----MEMLTKDKMDKDE 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1832 ELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLkgiadetQKSKLKAEEEAEKLKKLAAEEERRRK 1911
Cdd:TIGR00606  550 QIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL-------NKELASLEQNKNHINNELESKEEQLS 622

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1912 EAEEKVKRITAaeeeaarqCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTA----------AEQKAQ 1981
Cdd:TIGR00606  623 SYEDKLFDVCG--------SQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSccpvcqrvfqTEAELQ 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1982 DVLSK-NKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEA 2060
Cdd:TIGR00606  695 EFISDlQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLL 774

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2061 EEEAARRAaaeaaaLKQKQQADAEMskhkkeAEQALQQKSQVEKELTVVKLQLDETDkqkvlLDQELQRVKGEVNDafkq 2140
Cdd:TIGR00606  775 GTIMPEEE------SAKVCLTDVTI------MERFQMELKDVERKIAQQAAKLQGSD-----LDRTVQQVNQEKQE---- 833

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2141 ksqvevelarvriQMEELVKLKLKIEEeNRRLMQKDKDSTQKLlaeeaekmKSLAEEAGRLSVEAEETARQRQIAESNLA 2220
Cdd:TIGR00606  834 -------------KQHELDTVVSKIEL-NRKLIQDQQEQIQHL--------KSKTNELKSEKLQIGTNLQRRQQFEEQLV 891

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2221 EQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQ---AQETAKRLQEDKQQIQQRLDKETEGFQKSLEaerkrqleas 2297
Cdd:TIGR00606  892 ELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEElisSKETSNKKAQDKVNDIKEKVKNIHGYMKDIE---------- 961

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2298 aeaeklklrvkelSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEI------VVQKLETQRLQSTREADDLKSAIADL 2371
Cdd:TIGR00606  962 -------------NKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKInedmrlMRQDIDTQKIQERWLQDNLTLRKREN 1028

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2372 EEERKKLKKEAEELQrkSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLedemkKAKALKDEQE 2451
Cdd:TIGR00606 1029 ELKEVEEELKQHLKE--MGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKEL-----REPQFRDAEE 1101

                         1050
                   ....*....|....*...
gi 1389908296 2452 RQRKLMEEERKKLQAIMD 2469
Cdd:TIGR00606 1102 KYREMMIVMRTTELVNKD 1119
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3961-3999 4.19e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 71.59  E-value: 4.19e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3961 LLEAQIATGGIIDPQESHRLPVETAYERGLFDEEMNEIL 3999
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1344-1672 4.55e-15

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 82.48  E-value: 4.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1344 NIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQElrdRAAEAEKLRKAAQD-E 1422
Cdd:pfam17380  285 SERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAME---RERELERIRQEERKrE 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1423 AERLRKQ-VAEETQRKKnaedELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEkIRQIRVVEEVAQKSA 1501
Cdd:pfam17380  362 LERIRQEeIAMEISRMR----ELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVE-MEQIRAEQEEARQRE 436

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1502 ATQLQTKAMSFSEQTtKLEESLKKEQGNVLKLQEEADKLKKQQKEantaREEAEqeleiwRQKANEALRLRLQAEEEAQK 1581
Cdd:pfam17380  437 VRRLEEERAREMERV-RLEEQERQQQVERLRQQEEERKRKKLELE----KEKRD------RKRAEEQRRKILEKELEERK 505

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1582 KSHAQEEAEKQKLEAERDAK--------KRGKAEEAALKQKENAEKeldkqrkfaEQIAQQKLSAEQECIRLKADFEHAE 1653
Cdd:pfam17380  506 QAMIEEERKRKLLEKEMEERqkaiyeeeRRREAEEERRKQQEMEER---------RRIQEQMRKATEERSRLEAMERERE 576

                          330
                   ....*....|....*....
gi 1389908296 1654 QQRGLLDNELQRLKNEVNS 1672
Cdd:pfam17380  577 MMRQIVESEKARAEYEATT 595
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1452-1946 4.98e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.42  E-value: 4.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1452 KEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQK--------SAATQLQTKAMSFSEQTTKLEESL 1523
Cdd:PRK03918   168 GEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSElpelreelEKLEKEVKELEELKEEIEELEKEL 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1524 KKEQGNVLKLQEEADKLKKQQKEANTAREEAEQ---ELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDA 1600
Cdd:PRK03918   248 ESLEGSKRKLEEKIRELEERIEELKKEIEELEEkvkELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIE 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1601 KKRGKAEEAALKQKENAEKELDKQRKFAEqiAQQKLSAEQECIRLKADFEHAEQQRGllDNELQRLKNEVNSTEKQRKQL 1680
Cdd:PRK03918   328 ERIKELEEKEERLEELKKKLKELEKRLEE--LEERHELYEEAKAKKEELERLKKRLT--GLTPEKLEKELEELEKAKEEI 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1681 EDELNKVRSEMDSLLQMKINAEKASM---------------VNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQ 1745
Cdd:PRK03918   404 EEEISKITARIGELKKEIKELKKAIEelkkakgkcpvcgreLTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELR 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1746 ------IAEEEAARQRSEAEKI--LKEKLAAINeATRLKTEAEMALKAKE------AENERLKRQAEE-EAYQRKLLE-- 1808
Cdd:PRK03918   484 elekvlKKESELIKLKELAEQLkeLEEKLKKYN-LEELEKKAEEYEKLKEkliklkGEIKSLKKELEKlEELKKKLAEle 562

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1809 ---DQAAQHKQDIEEKITQLQTSS----DSELGRQKNIVEETLKQKKVV------EEEIHIIKINFHKASKEKADLESEL 1875
Cdd:PRK03918   563 kklDELEEELAELLKELEELGFESveelEERLKELEPFYNEYLELKDAEkelereEKELKKLEEELDKAFEELAETEKRL 642

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1876 KKLKGIADETQKSklKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAE 1946
Cdd:PRK03918   643 EELRKELEELEKK--YSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKK 711
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1266-1844 1.08e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 81.24  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEEE--------RRKMAEIQAELDK---QKQMAEA---HAKSVAKAEQEALELKMKMKEEASKR 1331
Cdd:PRK02224   184 DQRGSLDQLKAQIEEKEEKDlherlnglESELAELDEEIERyeeQREQAREtrdEADEVLEEHEERREELETLEAEIEDL 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1332 QDVAADAEKQKQNIQQELQHLKslsdqeiksknQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAE 1411
Cdd:PRK02224   264 RETIAETEREREELAEEVRDLR-----------ERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEE 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1412 AEKLRKAAQDEAERLRKQVA---EETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKykmQAEEAERRMKQAEEEKIR 1488
Cdd:PRK02224   333 CRVAAQAHNEEAESLREDADdleERAEELREEAAELESELEEAREAVEDRREEIEELEE---EIEELRERFGDAPVDLGN 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1489 QIRVVEEVAQKSAATQlqtkamsfsEQTTKLEESLKKEQGNVlklqEEADKLKKQQK--EANTAREEAE--QELEIWRQK 1564
Cdd:PRK02224   410 AEDFLEELREERDELR---------EREAELEATLRTARERV----EEAEALLEAGKcpECGQPVEGSPhvETIEEDRER 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1565 ANEALRLRLQAEEEaqkkshaqEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIR 1644
Cdd:PRK02224   477 VEELEAELEDLEEE--------VEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAE 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1645 LKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNtEKSKQLLESEALKMK 1724
Cdd:PRK02224   549 LEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLR-EKREALAELNDERRE 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1725 QLADEAARMRSVAEEAKKQRQiaeEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEeayqR 1804
Cdd:PRK02224   628 RLAEKRERKRELEAEFDEARI---EEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRER----R 700

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 1389908296 1805 KLLEDQaAQHKQDIEEKITQLQTSS---DSELgRQKNIveETL 1844
Cdd:PRK02224   701 EALENR-VEALEALYDEAEELESMYgdlRAEL-RQRNV--ETL 739
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2248-2538 1.78e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.75  E-value: 1.78e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2248 EKLQKQKDQAQEtAKRLQEDKQQIQQRL--------DKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAED 2319
Cdd:COG1196    203 EPLERQAEKAER-YRELKEELKELEAELlllklrelEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELEL 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2320 EAKKFKKQADEVKAQLQRTEKhttEIVVQKLETQRLQSTREADDLKsaiADLEEERKKLKKEAEELQRKSKEMANAQQEQ 2399
Cdd:COG1196    282 ELEEAQAEEYELLAELARLEQ---DIARLEERRRELEERLEELEEE---LAELEEELEELEEELEELEEELEEAEEELEE 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2400 IEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAE 2479
Cdd:COG1196    356 AEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2480 EEMKNKQREMDVLDKK-RLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKL 2538
Cdd:COG1196    436 EEEEEEEALEEAAEEEaELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 537-727 1.83e-14

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 75.56  E-value: 1.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  537 QLHAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAF 616
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  617 TAALQTQWSWLLQLCCCIETHLKENTAHFQFFTDVKEAEEKLKKMQDTMKRKYTCDrsiTVTRLEDLLQDAADEKEQLAE 696
Cdd:cd00176     81 LEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGK---DLESVEELLKKHKELEEELEA 157

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1389908296  697 FKTNLEALKRRAKTVIQLKPRNPTTPLKGKM 727
Cdd:cd00176    158 HEPRLKSLNELAEELLEEGHPDADEEIEEKL 188
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1308-2136 2.59e-14

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 80.15  E-value: 2.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1308 KSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKS--KNQQLEDALVSRRkieeEIHIIR 1385
Cdd:pfam05483    9 KSFNKCTEDDFEFPFAKSNLSKNGENIDSDPAFQKLNFLPMLEQVANSGDCHYQEglKDSDFENSEGLSR----LYSKLY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1386 IQLEKTTAHKAKSEAELQELRDRAAEAEKL----RKAAQD---EAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQK 1458
Cdd:pfam05483   85 KEAEKIKKWKVSIEAELKQKENKLQENRKIieaqRKAIQElqfENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETC 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1459 QRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEE--VAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVlklQEE 1536
Cdd:pfam05483  165 ARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEElrVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDK---EKQ 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1537 ADKLKKQQKEANTAREEAEQELEIWRQKANE-ALRLRLQAE---EEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALK 1612
Cdd:pfam05483  242 VSLLLIQITEKENKMKDLTFLLEESRDKANQlEEKTKLQDEnlkELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1613 QKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQqrgLLDNELQRLKNevnsTEKQRKQLEDELNKVRSEMD 1692
Cdd:pfam05483  322 ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEE---LLRTEQQRLEK----NEDQLKIITMELQKKSSELE 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1693 SLLQMKINAEkasmVNTEKSKQLLESEalkmKQLADEAARMRSVAEEAK-KQRQIAEEEAARQRSEAEKILKEKLAAINE 1771
Cdd:pfam05483  395 EMTKFKNNKE----VELEELKKILAED----EKLLDEKKQFEKIAEELKgKEQELIFLLQAREKEIHDLEIQLTAIKTSE 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1772 ATRLKTEAEMAlkaKEAENERLKRQAEEEAYQRKLLEDQaaqhkqdieeKITQLQTSSDSELGRQKNIVEETLKQKKVVE 1851
Cdd:pfam05483  467 EHYLKEVEDLK---TELEKEKLKNIELTAHCDKLLLENK----------ELTQEASDMTLELKKHQEDIINCKKQEERML 533

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1852 EEIHIIKinfHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQC 1931
Cdd:pfam05483  534 KQIENLE---EKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNI 610

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1932 KAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKedvLAQEKLRDEFENAKKLAQEA 2011
Cdd:pfam05483  611 EELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKK---ISEEKLLEEVEKAKAIADEA 687

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2012 EKAkekaekeaallrQKAEEAEKQKKAAENEA-AKQAKAQNDtekqrkeaeeeaarraaaeaaalKQKQQADAEMSKHKK 2090
Cdd:pfam05483  688 VKL------------QKEIDKRCQHKIAEMVAlMEKHKHQYD-----------------------KIIEERDSELGLYKN 732

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 1389908296 2091 EAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVND 2136
Cdd:pfam05483  733 KEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKE 778
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2978-3016 2.67e-14

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 69.28  E-value: 2.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2978 FLEAQAATGFVIDPIKNERVPVDEAVKSGLVGPEIHERL 3016
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1402-1902 4.10e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 79.70  E-value: 4.10e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1402 LQELRDRAAEA----EKLRKAAQDEAERLRKQVAEetqrkKNAEDELKRKSDAEKEAAKQKqralDDLQKYKMQAEEAER 1477
Cdd:PRK02224   164 LEEYRERASDArlgvERVLSDQRGSLDQLKAQIEE-----KEEKDLHERLNGLESELAELD----EEIERYEEQREQARE 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1478 RMKQAE------EEKIRQIRVVEEVAQKSAAtqlqTKAMSFSEQTTkLEESLKKEQGNVLKLQEE--------------A 1537
Cdd:PRK02224   235 TRDEADevleehEERREELETLEAEIEDLRE----TIAETEREREE-LAEEVRDLRERLEELEEErddllaeaglddadA 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1538 DKLKKQQKEANTAREEAEQELEIWRQKA----NEALRLR---LQAEEEAQKKSHAQEEAEKQKLEAERDAKKRG------ 1604
Cdd:PRK02224   310 EAVEARREELEDRDEELRDRLEECRVAAqahnEEAESLRedaDDLEERAEELREEAAELESELEEAREAVEDRReeieel 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1605 -KAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAE------------------------------ 1653
Cdd:PRK02224   390 eEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARerveeaealleagkcpecgqpvegsphvet 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1654 -----QQRGLLDNELQRLKNEVNSTEKQRKQLEDeLNKVRSEMDSLLQMKINAEKAsmvnTEKSKQLLESEALKMKQLAD 1728
Cdd:PRK02224   470 ieedrERVEELEAELEDLEEEVEEVEERLERAED-LVEAEDRIERLEERREDLEEL----IAERRETIEEKRERAEELRE 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1729 EAARMRSVAEEAKKQRQIAEEEAARQRSEAeKILKEKLAAINEA-TRLKTEAEMALKAKEAENERLKRQAEEEAYQRKll 1807
Cdd:PRK02224   545 RAAELEAEAEEKREAAAEAEEEAEEAREEV-AELNSKLAELKERiESLERIRTLLAAIADAEDEIERLREKREALAEL-- 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1808 EDQAAQHKQDIEEKITQLQTSSDSELgrqkniVEETLKQKKVVEEEIhiikinfhkaskekADLESELKKLKGIADETQK 1887
Cdd:PRK02224   622 NDERRERLAEKRERKRELEAEFDEAR------IEEAREDKERAEEYL--------------EQVEEKLDELREERDDLQA 681

                          570
                   ....*....|....*
gi 1389908296 1888 SKLKAEEEAEKLKKL 1902
Cdd:PRK02224   682 EIGAVENELEELEEL 696
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1533-2356 1.55e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.85  E-value: 1.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1533 LQEEADKLKKQQKEANTAREEAEQELEIWRQKANEaLRLRLQaeeEAQKKSHAQEEAEKQKLEAERDAKKRGKAE----E 1608
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVID-LQTKLQ---EMQMERDAMADIRRRESQSQEDLRNQLQNTvhelE 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1609 AALKQKENAEKELDKQrkfAEQIAQQKLSAE---QECIRLKADFEHAEQQR----------------GLLDNELQRLKNE 1669
Cdd:pfam15921  156 AAKCLKEDMLEDSNTQ---IEQLRKMMLSHEgvlQEIRSILVDFEEASGKKiyehdsmstmhfrslgSAISKILRELDTE 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1670 VNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKasmvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEE 1749
Cdd:pfam15921  233 ISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQ------DRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1750 EAARQRSEAEKILKEKLAAINEatrLKTEAEMALKAKEAENERLKRQ---AEEEAYQRKLLEDQAAQHKQDIEEKITQLQ 1826
Cdd:pfam15921  307 QARNQNSMYMRQLSDLESTVSQ---LRSELREAKRMYEDKIEELEKQlvlANSELTEARTERDQFSQESGNLDDQLQKLL 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1827 TSSDSelgRQKNIVEETLKQKKVVEEEIHiIKINFHKASKEKADLESELKKLKGIAdETQKSKLKAEEEAEklkklaAEE 1906
Cdd:pfam15921  384 ADLHK---REKELSLEKEQNKRLWDRDTG-NSITIDHLRRELDDRNMEVQRLEALL-KAMKSECQGQMERQ------MAA 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1907 ERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANkqkekaekeaekqvvlaKEAAQKCTAAEQKAQDVLSK 1986
Cdd:pfam15921  453 IQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSE-----------------RTVSDLTASLQEKERAIEAT 515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1987 NKEDVlaqeKLRDEFEnakklaqeaekakekaEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDtekqrkeaeeeaar 2066
Cdd:pfam15921  516 NAEIT----KLRSRVD----------------LKLQELQHLKNEGDHLRNVQTECEALKLQMAEKD-------------- 561

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2067 raaAEAAALKQKQQADAEM-SKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDafkqksqVE 2145
Cdd:pfam15921  562 ---KVIEILRQQIENMTQLvGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSD-------LE 631

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2146 VELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKL--LAEEAEKMK-SLAEEAGRLSVEAEETARQRQIAESNLAEQ 2222
Cdd:pfam15921  632 LEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELnsLSEDYEVLKrNFRNKSEEMETTTNKLKMQLKSAQSELEQT 711

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2223 RALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQE---DKQQIQQRLDKETEGFQKSLEAERKRQLEASAE 2299
Cdd:pfam15921  712 RNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEamtNANKEKHFLKEEKNKLSQELSTVATEKNKMAGE 791

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2300 AEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQ-KLETQRLQ 2356
Cdd:pfam15921  792 LEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVRLKLQhTLDVKELQ 849
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1612-2478 1.63e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.80  E-value: 1.63e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1612 KQKENAEKELDKQRKFAE----QIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKV 1687
Cdd:TIGR02169  205 REREKAERYQALLKEKREyegyELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDL 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1688 RSEMDSLLQMKINAEKASMVNTEKSKQLLESEAlkmkqladeaarmrsvaEEAKKQRQIAEEEAARQRSEAEKILKEkla 1767
Cdd:TIGR02169  285 GEEEQLRVKEKIGELEAEIASLERSIAEKEREL-----------------EDAEERLAKLEAEIDKLLAEIEELERE--- 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1768 aINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQtssdsELGRQKNIVEETLKQK 1847
Cdd:TIGR02169  345 -IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREIN-----ELKRELDRLQEELQRL 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1848 kvvEEEIHIIKINFHKASKEKADLESELKKLkgiADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEA 1927
Cdd:TIGR02169  419 ---SEELADLNAAIAGIEAKINELEEEKEDK---ALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQREL 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1928 AR---QCKAAQEEVeRLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKC--TAAEQKAQDVLSKNkeDVLAQEKLrdEFE 2002
Cdd:TIGR02169  493 AEaeaQARASEERV-RGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAieVAAGNRLNNVVVED--DAVAKEAI--ELL 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2003 NAKKLAQEAEKAKEKAEKEAALLRQKAE-----------EAEKQKKAA-----------EN-EAAKQAKAQN-----DTE 2054
Cdd:TIGR02169  568 KRRKAGRATFLPLNKMRDERRDLSILSEdgvigfavdlvEFDPKYEPAfkyvfgdtlvvEDiEAARRLMGKYrmvtlEGE 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2055 KQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAeqalqqksqVEKELTVVKLQLDETDKQKVLLDQELQRVKGEV 2134
Cdd:TIGR02169  648 LFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEG---------LKRELSSLQSELRRIENRLDELSQELSDASRKI 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2135 NDAFKQKSQVEVELARVRIQMEELVKLKLKIEEEnrrlMQKDKDSTQKLLAEEAEKMKSLAEeagrlsVEAEETARQRQI 2214
Cdd:TIGR02169  719 GEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQE----IENVKSELKELEARIEELEEDLHK------LEEALNDLEARL 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2215 AESNLAEQRALAEKILKEkmqaIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQL 2294
Cdd:TIGR02169  789 SHSRIPEIQAELSKLEEE----VSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKE 864

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2295 EASAEAEKLKLRVKELslaqtkaEDEAKKFKKQADEVKAQLQRTEKHtteivVQKLETQRLQSTREADDLKSAIADLEEE 2374
Cdd:TIGR02169  865 ELEEELEELEAALRDL-------ESRLGDLKKERDELEAQLRELERK-----IEELEAQIEKKRKRLSELKAKLEALEEE 932

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2375 RKKLKKEAEELQRKSKEMANAqqEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFekqledemkkakalkDEQERQR 2454
Cdd:TIGR02169  933 LSEIEDPKGEDEEIPEEELSL--EDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRL---------------DELKEKR 995

                          890       900
                   ....*....|....*....|....
gi 1389908296 2455 KLMEEERKKLQAIMDEAVRKQKEA 2478
Cdd:TIGR02169  996 AKLEEERKAILERIEEYEKKKREV 1019
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3642-3680 1.98e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 66.97  E-value: 1.98e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3642 LLEAQAATGFMIDPVKDELLTVDEAVRKGLVGPELHDKL 3680
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1688-2529 2.18e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.42  E-value: 2.18e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1688 RSEMDSLL-QMKINAEKASMVNTEKSKQLLESEALKMKQLADEAArmrSVAE-EAKKQRQIAEEEAARQRSE-AEKILKE 1764
Cdd:TIGR02169  119 LSEIHDFLaAAGIYPEGYNVVLQGDVTDFISMSPVERRKIIDEIA---GVAEfDRKKEKALEELEEVEENIErLDLIIDE 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1765 KlaaINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQ---HKQDIEEKITQLqTSSDSELGRQKNIVE 1841
Cdd:TIGR02169  196 K---RQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAierQLASLEEELEKL-TEEISELEKRLEEIE 271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1842 ETLKQ-----KKVVEEEIHIIKinfhkasKEKADLESELKKLKGIADEtqkSKLKAEEEAEKLKKLAAEEERRRKEAEEK 1916
Cdd:TIGR02169  272 QLLEElnkkiKDLGEEEQLRVK-------EKIGELEAEIASLERSIAE---KERELEDAEERLAKLEAEIDKLLAEIEEL 341

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1917 VKRItaaeEEAARQCKAAQEEVERLKKKAEDAnkqkekaekeaekqvvlakeaaqkctaaEQKAQDVLSKNKEDVLAQEK 1996
Cdd:TIGR02169  342 EREI----EEERKRRDKLTEEYAELKEELEDL----------------------------RAELEEVDKEFAETRDELKD 389

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1997 LRDEFEnakKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAArraaaeaaalk 2076
Cdd:TIGR02169  390 YREKLE---KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEW----------- 455

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2077 QKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQElQRVKGEVNDAFKQKSQVEVELARVRIQME 2156
Cdd:TIGR02169  456 KLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEER-VRGGRAVEEVLKASIQGVHGTVAQLGSVG 534

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2157 ELVKLKLKIEEENRR---LMQKDKDSTQ--KLLAEEA---------EKMKSLAEEAGRLS-----------VEAEETAR- 2210
Cdd:TIGR02169  535 ERYATAIEVAAGNRLnnvVVEDDAVAKEaiELLKRRKagratflplNKMRDERRDLSILSedgvigfavdlVEFDPKYEp 614

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2211 ------QRQIAESNLAEQRALAEKI--------LKEKMQAIQE-ATKLKAEAEKLQKQKDQAQETAKRLQEdkqqiqqrL 2275
Cdd:TIGR02169  615 afkyvfGDTLVVEDIEAARRLMGKYrmvtlegeLFEKSGAMTGgSRAPRGGILFSRSEPAELQRLRERLEG--------L 686

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2276 DKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEkhtteivvQKLETQRl 2355
Cdd:TIGR02169  687 KRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLE--------QEIENVK- 757

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2356 qstREADDLKSAIADLeeerkklkkeaeelqrksKEMANAQQEQIEQQKAELQQSFLTEKGLLLK-------------RE 2422
Cdd:TIGR02169  758 ---SELKELEARIEEL------------------EEDLHKLEEALNDLEARLSHSRIPEIQAELSkleeevsriearlRE 816

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2423 KEVEGEKKRFEKQ-LEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEK 2501
Cdd:TIGR02169  817 IEQKLNRLTLEKEyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA 896

                          890       900
                   ....*....|....*....|....*...
gi 1389908296 2502 QLAEENKKLREQLQTFEISSKTVSQTKE 2529
Cdd:TIGR02169  897 QLRELERKIEELEAQIEKKRKRLSELKA 924
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1241-1825 2.52e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 77.26  E-value: 2.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNLRTRYSELMTLtnqyikfiiDAQRRLEDDEKASEKLKEEERRkmaeIQAELDKQKQMAEAHAKSVAKAEQEALEL 1320
Cdd:COG4913    262 ERYAAARERLAELEYL---------RAALRLWFAQRRLELLEAELEE----LRAELARLEAELERLEARLDALREELDEL 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1321 kmkmkeeaskRQDVAADAEKQKQNIQQELQHLKSLSDqEIKSKNQQLEDALVS-RRKIEEEIHIIRIQLEKTTAHKAKSE 1399
Cdd:COG4913    329 ----------EAQIRGNGGDRLEQLEREIERLERELE-ERERRRARLEALLAAlGLPLPASAEEFAALRAEAAALLEALE 397

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1400 AELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALD---DLqkykMQAEEAE 1476
Cdd:COG4913    398 EELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAELPfvgEL----IEVRPEE 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1477 RRMKQAEEEKIRQIR---VVEEVAQKSAA-----TQLQTKAmsfseQTTKLEESLKKEQGNVLKLQEEADKLkkqQKEAN 1548
Cdd:COG4913    474 ERWRGAIERVLGGFAltlLVPPEHYAAALrwvnrLHLRGRL-----VYERVRTGLPDPERPRLDPDSLAGKL---DFKPH 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1549 TAREEAEQEL-----------------------------------EIWRQKA----------NEALRLRLQAEEEAQKKS 1583
Cdd:COG4913    546 PFRAWLEAELgrrfdyvcvdspeelrrhpraitragqvkgngtrhEKDDRRRirsryvlgfdNRAKLAALEAELAELEEE 625

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1584 HAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirlKADFEHAEQQRGLLDNEL 1663
Cdd:COG4913    626 LAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDAS----SDDLAALEEQLEELEAEL 701

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1664 QRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEkasmvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQ 1743
Cdd:COG4913    702 EELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAE-------DLARLELRALLEERFAAALGDAVERELRENLEER 774

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1744 RQIAEEEAARQRSEAEKILKE--------------KLAAINEA----TRLKTEaemALKAKEAE-NERLKRQAEEEayqR 1804
Cdd:COG4913    775 IDALRARLNRAEEELERAMRAfnrewpaetadldaDLESLPEYlallDRLEED---GLPEYEERfKELLNENSIEF---V 848

                          650       660
                   ....*....|....*....|.
gi 1389908296 1805 KLLEDQAAQHKQDIEEKITQL 1825
Cdd:COG4913    849 ADLLSKLRRAIREIKERIDPL 869
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1804-2519 4.40e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 76.25  E-value: 4.40e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1804 RKLLEDQA--AQHKQDIEEKITQLQTSSDSeLGRQKNIVEETLKQKKVVEEEIHI-IKINFHKASKEKADLESELKKLKG 1880
Cdd:TIGR02168  158 RAIFEEAAgiSKYKERRKETERKLERTREN-LDRLEDILNELERQLKSLERQAEKaERYKELKAELRELELALLVLRLEE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1881 IADETQKSKLKAEEEAEKLKKLAAEEERrrkeAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAE 1960
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQE----LEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1961 KQVVLAKEAAQKCTAAEQKAQDVL-----SKNKEDVLAQEK--LRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAE 2033
Cdd:TIGR02168  313 NLERQLEELEAQLEELESKLDELAeelaeLEEKLEELKEELesLEAELEELEAELEELESRLEELEEQLETLRSKVAQLE 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2034 KQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQadAEMSKHKKEAEQALQQKSQVEKELTVVKLQL 2113
Cdd:TIGR02168  393 LQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQ--AELEELEEELEELQEELERLEEALEELREEL 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2114 DETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKL---------KLKIEEENRRLMQKD-KDSTQKL 2183
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsgilgvlseLISVDEGYEAAIEAAlGGRLQAV 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2184 LAEEAEKMKSLAE-----EAGRLSVEAEETARQRQIaESNLAEQRALAEKILKEKMQAIQEATKLK-------------- 2244
Cdd:TIGR02168  551 VVENLNAAKKAIAflkqnELGRVTFLPLDSIKGTEI-QGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvd 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2245 --AEAEKLQKQKD----------------------------QAQETAKRLQEDKQQIQQRLDKETEGfQKSLEAERKRQL 2294
Cdd:TIGR02168  630 dlDNALELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEELEEKIAEL-EKALAELRKELE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2295 EASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQklETQRLQSTREADDLKSAIADLEEE 2374
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE--IEELEERLEEAEEELAEAEAEIEE 786

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2375 RKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKR---EKEVEGEKKRFEKQLEDEMKKAKALKDEQE 2451
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIaatERRLEDLEEQIEELSEDIESLAAEIEELEE 866

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 2452 RQRKLmEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKL---REQLQTFEI 2519
Cdd:TIGR02168  867 LIEEL-ESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEV 936
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3385-3421 6.50e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 65.43  E-value: 6.50e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1389908296 3385 LLEAQLATGGIIDPASSHRVPTDVAIQRGYFSKQMAK 3421
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1171-1820 7.36e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 75.60  E-value: 7.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1171 LREQLTDEKKLLGEIEKNKDkiddchknakayidsvkdyefqiltykalqdpiasplkkpKMECASDDIIQEYVNLRTRY 1250
Cdd:pfam01576  192 LEERLKKEEKGRQELEKAKR----------------------------------------KLEGESTDLQEQIAELQAQI 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1251 SELMTLTNQYIKFIIDAQRRLEDDEKAseklKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMK---MKEE 1327
Cdd:pfam01576  232 AELRAQLAKKEEELQAALARLEEETAQ----KNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEEleaLKTE 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1328 ASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDAlvsRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELrd 1407
Cdd:pfam01576  308 LEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEM---RQKHTQALEELTEQLEQAKRNKANLEKAKQAL-- 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1408 raaeaEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEeki 1487
Cdd:pfam01576  383 -----ESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEG--- 454

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1488 RQIRVVEEVAqkSAATQLQTKAMSFSEQT-TKLEESLKKEQgnvlkLQEEADKLKKQQKEANTAREEAEQELEIWRQ--- 1563
Cdd:pfam01576  455 KNIKLSKDVS--SLESQLQDTQELLQEETrQKLNLSTRLRQ-----LEDERNSLQEQLEEEEEAKRNVERQLSTLQAqls 527

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1564 ---KANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQK-ENAEKELD-----------KQRKFA 1628
Cdd:pfam01576  528 dmkKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQElDDLLVDLDhqrqlvsnlekKQKKFD 607

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1629 EQIAQQKLSAEQ---ECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLedelnkvRSEMDSLLQMKINAEKaS 1705
Cdd:pfam01576  608 QMLAEEKAISARyaeERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQL-------RAEMEDLVSSKDDVGK-N 679

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1706 MVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAK---------------KQRQIAEEEAARQRSEAEKILKEKLAAIN 1770
Cdd:pfam01576  680 VHELERSKRALEQQVEEMKTQLEELEDELQATEDAKlrlevnmqalkaqfeRDLQARDEQGEEKRRQLVKQVRELEAELE 759

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1771 EATRLKTEA-------EMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEE 1820
Cdd:pfam01576  760 DERKQRAQAvaakkklELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEE 816
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1259-1555 7.65e-13

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 75.16  E-value: 7.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1259 QYIKFIIDAQRRLEDDEKasEKLKE-EERRKMAEI----QAELDKQKQMAEAHAKSVAKAEQEALELKM---KMKEEASK 1330
Cdd:pfam17380  289 QQEKFEKMEQERLRQEKE--EKAREvERRRKLEEAekarQAEMDRQAAIYAEQERMAMERERELERIRQeerKRELERIR 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1331 RQDVAADAEKQKqniqqELQHLKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELR---- 1406
Cdd:pfam17380  367 QEEIAMEISRMR-----ELERLQ----MERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARqrev 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1407 -----DRAAEAEKLRKAA-----------QDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKM 1470
Cdd:pfam17380  438 rrleeERAREMERVRLEEqerqqqverlrQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKL 517

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1471 QAEEAERRMKQAEEEKIRQIRVVEEVAQKSAAT--QLQTKAMSFSEQTTKLeESLKKEQgnvlklqeeadKLKKQQKEAN 1548
Cdd:pfam17380  518 LEKEMEERQKAIYEEERRREAEEERRKQQEMEErrRIQEQMRKATEERSRL-EAMERER-----------EMMRQIVESE 585


                   ....*..
gi 1389908296 1549 TAREEAE 1555
Cdd:pfam17380  586 KARAEYE 592
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1259-1949 7.71e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.54  E-value: 7.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1259 QYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKE-----EASK--R 1331
Cdd:pfam15921   82 EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNtvhelEAAKclK 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1332 QDVAADAEKQKQNIQQ-ELQHLKSLsdQEIKSKNQQLEDAlvSRRKIEEEIHIIRIQLEKTTAHKAKS----EAELQELR 1406
Cdd:pfam15921  162 EDMLEDSNTQIEQLRKmMLSHEGVL--QEIRSILVDFEEA--SGKKIYEHDSMSTMHFRSLGSAISKIlrelDTEISYLK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1407 DR----AAEAEKLRKAAQDEAERLRKQ------------------VAEETQRKKNAEDELKRKSDAEKEAAKQKQ----R 1460
Cdd:pfam15921  238 GRifpvEDQLEALKSESQNKIELLLQQhqdrieqliseheveitgLTEKASSARSQANSIQSQLEIIQEQARNQNsmymR 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1461 ALDDLQKYKMQAEEAERRMKQAEEEKIRQIRvVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKL 1540
Cdd:pfam15921  318 QLSDLESTVSQLRSELREAKRMYEDKIEELE-KQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1541 KKQQKEA------------NTAREEAEQELEIWRQkanEALRLRLqaeeeaqkKSHAQEEAEKQKleaerdAKKRGKAEE 1608
Cdd:pfam15921  397 KEQNKRLwdrdtgnsitidHLRRELDDRNMEVQRL---EALLKAM--------KSECQGQMERQM------AAIQGKNES 459

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1609 AALKQKENAEKELDKQ--RKFAEQIAQQKL---SAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDE 1683
Cdd:pfam15921  460 LEKVSSLTAQLESTKEmlRKVVEELTAKKMtleSSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNE 539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1684 LNKVRSemdslLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQrqiAEEEAARQRSEAE--KI 1761
Cdd:pfam15921  540 GDHLRN-----VQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQ---LEKEINDRRLELQefKI 611

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1762 LKEKL-AAINEATRLKTEAEM-ALKAKEAENERLKRQaeeeayqrklledqaaqhkQDIEEKITQLQtssdselgrqkNI 1839
Cdd:pfam15921  612 LKDKKdAKIRELEARVSDLELeKVKLVNAGSERLRAV-------------------KDIKQERDQLL-----------NE 661

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1840 VEETLKQKKVVEEEIHIIKINFHKASKEkadLESELKKLKGiadETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKR 1919
Cdd:pfam15921  662 VKTSRNELNSLSEDYEVLKRNFRNKSEE---METTTNKLKM---QLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQ 735

                          730       740       750
                   ....*....|....*....|....*....|
gi 1389908296 1920 ITAAEEeaarQCKAAQEEVERLKKKAEDAN 1949
Cdd:pfam15921  736 ITAKRG----QIDALQSKIQFLEEAMTNAN 761
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1169-1826 1.00e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 1.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1169 RALREQLTDEKK--LLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYKALQDpiASPLKKPKMECASDDIIQEYVNL 1246
Cdd:TIGR02168  216 KELKAELRELELalLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLE--ELRLEVSELEEEIEELQKELYAL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1247 RTRYSELmtltNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKE 1326
Cdd:TIGR02168  294 ANEISRL----EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEE 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1327 EASKRQDVAADAEKQKQNIQQELQHLKSLSDQeIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKttAHKAKSEAELQELR 1406
Cdd:TIGR02168  370 LESRLEELEEQLETLRSKVAQLELQIASLNNE-IERLEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAELEELE 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1407 DRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKS-----------------DAEKEAAKQKQR--------- 1460
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQarldslerlqenlegfsEGVKALLKNQSGlsgilgvls 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1461 --------------------------------------------------ALDDLQKYKMQAEEAERRMKQAE------- 1483
Cdd:TIGR02168  527 elisvdegyeaaieaalggrlqavvvenlnaakkaiaflkqnelgrvtflPLDSIKGTEIQGNDREILKNIEGflgvakd 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1484 ----EEKIR--------QIRVVEEVAQksaATQLQTK-------------------AMSFSEQTT------------KLE 1520
Cdd:TIGR02168  607 lvkfDPKLRkalsyllgGVLVVDDLDN---ALELAKKlrpgyrivtldgdlvrpggVITGGSAKTnssilerrreieELE 683

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1521 ESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEA-------------LRLRLQAEEEAQKKSHAQE 1587
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALrkdlarleaeveqLEERIAQLSKELTELEAEI 763

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1588 EAEKQKLEAERDAKKRGKAEEAALKQK---------------ENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHA 1652
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQieqlkeelkalrealDELRAELTLLNEEAANLRERLESLERRIAATERRLEDL 843

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1653 EQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSlLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEA-- 1730
Cdd:TIGR02168  844 EEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAS-LEEALALLRSELEELSEELRELESKRSELRRELEELre 922

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1731 --ARMRSVAEEAKKQR-QIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEmALKAKEAENERLKRQAEEEAYQRKLL 1807
Cdd:TIGR02168  923 klAQLELRLEGLEVRIdNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLK-RLENKIKELGPVNLAAIEEYEELKER 1001

                          810
                   ....*....|....*....
gi 1389908296 1808 EDQAAQHKQDIEEKITQLQ 1826
Cdd:TIGR02168 1002 YDFLTAQKEDLTEAKETLE 1020
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1519-1947 1.01e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 74.80  E-value: 1.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1519 LEESLKKEQGNVLKLQEEADKLKKQQ-KEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEK-QKLEA 1596
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKElKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKlEKLLQ 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1597 ERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLD-NELQRLKNEVNSTEK 1675
Cdd:COG4717    127 LLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATeEELQDLAEELEELQQ 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1676 QRKQLEDELNKVRSEMDSLLQmKINAEKASMVNTEKSKQLLESEAL---------------------------------- 1721
Cdd:COG4717    207 RLAELEEELEEAQEELEELEE-ELEQLENELEAAALEERLKEARLLlliaaallallglggsllsliltiagvlflvlgl 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1722 -------KMKQLADEAARMRSVAEEAKKQRqIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLK 1794
Cdd:COG4717    286 lallfllLAREKASLGKEAEELQALPALEE-LEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQ 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1795 RQAEEEAYQRKLLEDQA------------AQHKQDIEEKITQLQTSSDSELGRQKNIVEETlkQKKVVEEEIHIIKINFH 1862
Cdd:COG4717    365 LEELEQEIAALLAEAGVedeeelraaleqAEEYQELKEELEELEEQLEELLGELEELLEAL--DEEELEEELEELEEELE 442

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1863 KASKEKADLESELKKLkgiadETQKSKLKAEEEAEKLKklaaeeerrrKEAEEKVKRITAAEEEAARqCKAAQEEVERLK 1942
Cdd:COG4717    443 ELEEELEELREELAEL-----EAELEQLEEDGELAELL----------QELEELKAELRELAEEWAA-LKLALELLEEAR 506


                   ....*
gi 1389908296 1943 KKAED 1947
Cdd:COG4717    507 EEYRE 511
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1832-2538 1.02e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 1.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1832 ELGRQKNIVEETLKQKKVVEEE---IHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLaaeeer 1908
Cdd:TIGR02168  142 EQGKISEIIEAKPEERRAIFEEaagISKYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERY------ 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1909 rrkeaeekvKRITAAEEEA-----ARQCKAAQEEVERLKKKAedankqkekaekeaekqvvlaKEAAQKCTAAEQKAQDV 1983
Cdd:TIGR02168  216 ---------KELKAELRELelallVLRLEELREELEELQEEL---------------------KEAEEELEELTAELQEL 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1984 LSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQakaqndtekqrkeaeee 2063
Cdd:TIGR02168  266 EEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEEL----------------- 328

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2064 aarraaaeaaaLKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQ 2143
Cdd:TIGR02168  329 -----------ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS 397

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2144 VEVELARVRIQMEELvklklkiEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQR 2223
Cdd:TIGR02168  398 LNNEIERLEARLERL-------EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREEL 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2224 ALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLD------KETEGFQKSLEA--------- 2288
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGvlseliSVDEGYEAAIEAalggrlqav 550

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2289 ------ERKRQLEASAEAEKLKLRVKELSLAQ-TKAEDEAKKFKKQADEVKAQLQRTEKHTTEIvvQKLETQRLQSTREA 2361
Cdd:TIGR02168  551 vvenlnAAKKAIAFLKQNELGRVTFLPLDSIKgTEIQGNDREILKNIEGFLGVAKDLVKFDPKL--RKALSYLLGGVLVV 628

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2362 DDLKSAIADLEEERKKL--------------------KKEAEELQRKSKEMANAQQE-----------QIEQQKAELQQS 2410
Cdd:TIGR02168  629 DDLDNALELAKKLRPGYrivtldgdlvrpggvitggsAKTNSSILERRREIEELEEKieeleekiaelEKALAELRKELE 708

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2411 FLTEKGLLLKREKE--------VEGEKKRFEK---QLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAE 2479
Cdd:TIGR02168  709 ELEEELEQLRKELEelsrqisaLRKDLARLEAeveQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2480 EEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKL 2538
Cdd:TIGR02168  789 AQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1260-1896 1.33e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.72  E-value: 1.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1260 YIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKmkmkeeaskrqdvaadae 1339
Cdd:PRK03918   173 EIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELE------------------ 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1340 kqkqniqqelqhlkslsdqEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKaksEAELQELRDRAAEAEKLRKAA 1419
Cdd:PRK03918   235 -------------------ELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL---KKEIEELEEKVKELKELKEKA 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1420 qDEAERLRKQVAEETQRKKNAEDELKRKSdaekEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRqirvveevaqk 1499
Cdd:PRK03918   293 -EEYIKLSEFYEEYLDELREIEKRLSRLE----EEINGIEERIKELEEKEERLEELKKKLKELEKRLEE----------- 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1500 saatqLQTKAMSFSEQTTKLE--ESLKKEQGNvlklqEEADKLKKQQKEANTAREEAEQELEIWRQKANE------ALRL 1571
Cdd:PRK03918   357 -----LEERHELYEEAKAKKEelERLKKRLTG-----LTPEKLEKELEELEKAKEEIEEEISKITARIGElkkeikELKK 426

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1572 RLQAEEEAQKK----------SHAQEEAEKQKLEAERDAKKRGKAEEA---ALKQKENAEKELDKQRKFA--EQIAQQKL 1636
Cdd:PRK03918   427 AIEELKKAKGKcpvcgrelteEHRKELLEEYTAELKRIEKELKEIEEKerkLRKELRELEKVLKKESELIklKELAEQLK 506

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1637 SAEQECirLKADFEHAEQQRglldNELQRLKNEVNSTEKQRKQLEDELNkvrsemdsllqmKINAEKASMVNTEKSKQLL 1716
Cdd:PRK03918   507 ELEEKL--KKYNLEELEKKA----EEYEKLKEKLIKLKGEIKSLKKELE------------KLEELKKKLAELEKKLDEL 568

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1717 ESEalkMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQ 1796
Cdd:PRK03918   569 EEE---LAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEEL 645

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1797 AEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKinfhKASKEKADLESELK 1876
Cdd:PRK03918   646 RKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE----KAKKELEKLEKALE 721

                          650       660
                   ....*....|....*....|
gi 1389908296 1877 KLKGIADETQKSKLKAEEEA 1896
Cdd:PRK03918   722 RVEELREKVKKYKALLKERA 741
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3309-3347 1.38e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.66  E-value: 1.38e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3309 LLEAQAATGFITDPVKDKKCSVDDAVKEGIVGPELHEKL 3347
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2652-2690 1.74e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 64.27  E-value: 1.74e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2652 LLEAQAASGFIVDPVKNKFLSVDEAVKDKVIGPELHDRL 2690
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1245-1847 2.00e-12

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 74.02  E-value: 2.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1245 NLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDkqkqmAEAHAKSVAKAEQEALELKMKM 1324
Cdd:pfam07111   52 SLELEGSQALSQQAELISRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELD-----ALAVAEKAGQAEAEGLRAALAG 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1325 KEEASKRQDVAAdaekqkqniQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAElqe 1404
Cdd:pfam07111  127 AEMVRKNLEEGS---------QRELEEIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLETKRAGEAKQLAE--- 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1405 lrdraaeaeklrkaAQDEAERLRKQVAE------------ETQRKKNAEDELKRKSDAEKEAAKQK--------QRALDD 1464
Cdd:pfam07111  195 --------------AQKEAELLRKQLSKtqeeleaqvtlvESLRKYVGEQVPPEVHSQTWELERQElldtmqhlQEDRAD 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1465 LQK---------------YKMQAEEAERRMKQA---EEEKIRQIR-VVEEVAQKSAATQLQTKAmsfseQTTKLEESLKK 1525
Cdd:pfam07111  261 LQAtvellqvrvqslthmLALQEEELTRKIQPSdslEPEFPKKCRsLLNRWREKVFALMVQLKA-----QDLEHRDSVKQ 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1526 EQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKAnEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGK 1605
Cdd:pfam07111  336 LRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSA-KGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQ 414

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1606 A---------EEAALK------------QKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKAD----FEHAEQQRGLLD 1660
Cdd:pfam07111  415 IwlettmtrvEQAVARipslsnrlsyavRKVHTIKGLMARKVALAQLRQESCPPPPPAPPVDADlsleLEQLREERNRLD 494

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1661 NELQR----LKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKinaeKASMVNTeksKQLLESEALKMKQLADEAARMRsv 1736
Cdd:pfam07111  495 AELQLsahlIQQEVGRAREQGEAERQQLSEVAQQLEQELQRA----QESLASV---GQQLEVARQGQQESTEEAASLR-- 565

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1737 aEEAKKQRQIAEEEAARQRSEAEKILKEKLA----AINEATRLKTEAEMALKAKEAENERLKRQAEEeayQRKLLEDQAA 1812
Cdd:pfam07111  566 -QELTQQQEIYGQALQEKVAEVETRLREQLSdtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQE---LRRLQDEARK 641

                          650       660       670
                   ....*....|....*....|....*....|....*
gi 1389908296 1813 QHKQDIEEKItqlqtssdSELGRQKNIVEETLKQK 1847
Cdd:pfam07111  642 EEGQRLARRV--------QELERDKNLMLATLQQE 668
CH_MICALL2 cd21253
calponin homology (CH) domain found in MICAL-like protein 2 and similar proteins; MICAL-like ...
 111-168 2.14e-12

calponin homology (CH) domain found in MICAL-like protein 2 and similar proteins; MICAL-like protein 2 (MICAL-L2), also called junctional Rab13-binding protein (JRAB), or molecule interacting with CasL-like 2, acts as an effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecule transport to the plasma membrane, and actin cytoskeleton reorganization. It regulates the endocytic recycling of occludins, claudins, and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. Members of this subfamily contain a single copy of CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409102  Cd Length: 106  Bit Score: 66.22  E-value: 2.14e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21253     44 PDLIDFDSLSKENVYENNKLAFTVAEKELGIPALLDAEDmVALKVPDKLSILTYVSQYY 102
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 2222-2515 2.65e-12

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 73.23  E-value: 2.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2222 QRALAEKILKEKMQaiqeatklKAEAEKLQKQKDQ-AQETAKR--LQEDKQQIQQRLDKetegfQKSLEAERKR-QLEAS 2297
Cdd:pfam17380  281 QKAVSERQQQEKFE--------KMEQERLRQEKEEkAREVERRrkLEEAEKARQAEMDR-----QAAIYAEQERmAMERE 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2298 AEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHttEIVVQKLETQRLQSTREADdlksaiadleeERKK 2377
Cdd:pfam17380  348 RELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKN--ERVRQELEAARKVKILEEE-----------RQRK 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2378 LKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEgekkRFEKQLEDEMKKAKALKDEQERQRKLM 2457
Cdd:pfam17380  415 IQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVE----RLRQQEEERKRKKLELEKEKRDRKRAE 490

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 2458 EEERKKLQAIMDEavRKQKEAEEEMKNKQREMDVLDKKRL---EQEKQLAEENKKLREQLQ 2515
Cdd:pfam17380  491 EQRRKILEKELEE--RKQAMIEEERKRKLLEKEMEERQKAiyeEERRREAEEERRKQQEME 549
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1276-1901 4.07e-12

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 72.83  E-value: 4.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1276 KASEKLK--EEERRKMAEIQAELDKQ-KQMAEAHAKSVAKAEQEALELKMKMKEEASKrqdvaadaekqkqniqqeLQHL 1352
Cdd:pfam05483  166 RSAEKTKkyEYEREETRQVYMDLNNNiEKMILAFEELRVQAENARLEMHFKLKEDHEK------------------IQHL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1353 KSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEkttahkakseaelqELRDRAAEAEKLRKAAQDEAERLRKQVAE 1432
Cdd:pfam05483  228 EEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLE--------------ESRDKANQLEEKTKLQDENLKELIEKKDH 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1433 ETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYkmqAEEAERRMKQAEEEKIRQIRVVEEVaqKSAATQLQTKAMSF 1512
Cdd:pfam05483  294 LTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQL---TEEKEAQMEELNKAKAAHSFVVTEF--EATTCSLEELLRTE 368

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1513 SEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREE-----AEQELEIWRQKANEALRLRLQAEEEAQKKSHAQE 1587
Cdd:pfam05483  369 QQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEElkkilAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAR 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1588 EAEKQKLEAERDAKKrgKAEEAALKQKENAEKELDKQR-KFAEQIAQ-QKLSAEQECIRLKAD---FEHAEQQRGLLDNE 1662
Cdd:pfam05483  449 EKEIHDLEIQLTAIK--TSEEHYLKEVEDLKTELEKEKlKNIELTAHcDKLLLENKELTQEASdmtLELKKHQEDIINCK 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1663 LQ--RLKNEVNSTEKQRKQLEDELNKVRSEmdslLQMKINAEKASMVNTEKSKQLLESEALK----MKQLADEAARMRSV 1736
Cdd:pfam05483  527 KQeeRMLKQIENLEEKEMNLRDELESVREE----FIQKGDEVKCKLDKSEENARSIEYEVLKkekqMKILENKCNNLKKQ 602

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1737 AEEAKKQRQIAEEE--AARQRSEAE-------KILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQA-EEEAYQRKL 1806
Cdd:pfam05483  603 IENKNKNIEELHQEnkALKKKGSAEnkqlnayEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKlLEEVEKAKA 682

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1807 LEDQAAQHKQDI----EEKITQLQTSSDSELGRQKNIVEETlkqkkvvEEEIHIIKINFHKASKEKADLESELKKLKGIA 1882
Cdd:pfam05483  683 IADEAVKLQKEIdkrcQHKIAEMVALMEKHKHQYDKIIEER-------DSELGLYKNKEQEQSSAKAALEIELSNIKAEL 755

                          650
                   ....*....|....*....
gi 1389908296 1883 DETQKSKLKAEEEAEKLKK 1901
Cdd:pfam05483  756 LSLKKQLEIEKEEKEKLKM 774
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4231-4269 4.24e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 63.12  E-value: 4.24e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 4231 LLEAQACTGGIIDPNTGEKFSVVDAMNKGLVDKIMVDRI 4269
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1290-1750 4.73e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.49  E-value: 4.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1290 AEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAAdAEKQKQNIQQELQHLKSLSDQeiKSKNQQLED 1369
Cdd:COG4717     53 KEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEE-LEEELEELEAELEELREELEK--LEKLLQLLP 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1370 ALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSD 1449
Cdd:COG4717    130 LYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLA 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1450 AEKEAAKQKQRALDDLQKYKMQAEEAERRmkQAEEEKIRQIRVV------------EEVAQKSAATQLQTKAMSFSEQTT 1517
Cdd:COG4717    210 ELEEELEEAQEELEELEEELEQLENELEA--AALEERLKEARLLlliaaallallgLGGSLLSLILTIAGVLFLVLGLLA 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1518 KLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAE 1597
Cdd:COG4717    288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEE 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1598 RDAKKRGKAEEAALKQKENAEKELDKQRKFaEQIAQQKLSAEQECIRLKADFEHAEQQRGL--LDNELQRLKNEVNSTEK 1675
Cdd:COG4717    368 LEQEIAALLAEAGVEDEEELRAALEQAEEY-QELKEELEELEEQLEELLGELEELLEALDEeeLEEELEELEEELEELEE 446

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 1676 QRKQLEDELNKVRSEMDSLLQMKINAEKasmvnteksKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEE 1750
Cdd:COG4717    447 ELEELREELAELEAELEQLEEDGELAEL---------LQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1996-2541 4.94e-12

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 72.45  E-value: 4.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1996 KLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEaarraaaeaaaL 2075
Cdd:pfam05483  216 KLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDEN-----------L 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEAEQALQQKSQVEKELtvvKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQM 2155
Cdd:pfam05483  285 KELIEKKDHLTKELEDIKMSLQRSMSTQKAL---EEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2156 EELVKlklkieeenrrlmqkdkdSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRalaeKILKEKMQ 2235
Cdd:pfam05483  362 EELLR------------------TEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELK----KILAEDEK 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2236 AIQEATKLKAEAEKLQKQKdqaQETAKRLQEDKQQI-------------QQRLDKETEGFQKSLEAERKRQLEASAEAEK 2302
Cdd:pfam05483  420 LLDEKKQFEKIAEELKGKE---QELIFLLQAREKEIhdleiqltaiktsEEHYLKEVEDLKTELEKEKLKNIELTAHCDK 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2303 LKLRVKELS-------LAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVvQKLETQRLQSTREADDLKSAIADLEEER 2375
Cdd:pfam05483  497 LLLENKELTqeasdmtLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR-DELESVREEFIQKGDEVKCKLDKSEENA 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2376 KKLKKEAEELQ-------------RKSKEMANAQQEQIEQQKAELQQSFLTEKGLLL-------KREKEVEGEKKRFEKQ 2435
Cdd:pfam05483  576 RSIEYEVLKKEkqmkilenkcnnlKKQIENKNKNIEELHQENKALKKKGSAENKQLNayeikvnKLELELASAKQKFEEI 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2436 LEDEMKKAKALKDEQERqrklMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENK------K 2509
Cdd:pfam05483  656 IDNYQKEIEDKKISEEK----LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDselglyK 731

                          570       580       590
                   ....*....|....*....|....*....|...
gi 1389908296 2510 LREQLQ-TFEISSKTVSQTKESQTVSVEKLVAV 2541
Cdd:pfam05483  732 NKEQEQsSAKAALEIELSNIKAELLSLKKQLEI 764
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2728-2766 1.41e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 61.57  E-value: 1.41e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 2728 FLDVQLATGGIIDPVNSHRVPLQTAYSQGQFDADMNKKL 2766
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3718-3756 1.48e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 61.57  E-value: 1.48e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3718 LLEAQNATGGYMDPEYYFRLPIDVAMQRGYINKETHERL 3756
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1400-1835 1.79e-11

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 71.14  E-value: 1.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1400 AELQELRDRAAEAEKLRKAAqdeaerlRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYkMQAeeaerrM 1479
Cdd:COG3096    278 NERRELSERALELRRELFGA-------RRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLV-QTA------L 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1480 KQAEeeKIrqIRVVEEVAQKSAATQLQtkamsfSEQTTKLEESLKKEQGNVLKLQEEADKLKKQ----------QKEANT 1549
Cdd:COG3096    344 RQQE--KI--ERYQEDLEELTERLEEQ------EEVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyqqaldvQQTRAI 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1550 AREEAEQELEiwrqKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELdkqRKFAE 1629
Cdd:COG3096    414 QYQQAVQALE----KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELV---CKIAG 486

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1630 QI-AQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEdELNKvrsemdsllQMKINAEKASMVN 1708
Cdd:COG3096    487 EVeRSQAWQTARELLRRYRSQQALAQRLQQLRAQLAELEQRLRQQQNAERLLE-EFCQ---------RIGQQLDAAEELE 556

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1709 TEKSKQllesEAlkmkQLADEAARMRSVAEEAKKQRQiAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEA 1788
Cdd:COG3096    557 ELLAEL----EA----QLEELEEQAAEAVEQRSELRQ-QLEQLRARIKELAARAPAWLAAQDALERLREQSGEALADSQE 627

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 1789 ENERLKRQAEEEAyQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGR 1835
Cdd:COG3096    628 VTAAMQQLLERER-EATVERDELAARKQALESQIERLSQPGGAEDPR 673
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2076-2306 2.17e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 69.02  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQM 2155
Cdd:COG4942     27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2156 EELVKLKLKIEEENR---RLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQiaesNLAEQRALAEKILKE 2232
Cdd:COG4942    107 AELLRALYRLGRQPPlalLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA----ELEAERAELEALLAE 182

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2233 KMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLR 2306
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGKLP 256
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1417-1641 2.42e-11

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 68.72  E-value: 2.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1417 KAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLqKYKMQAEEAERRMKQAEEEKIRQIRVVEEV 1496
Cdd:TIGR02794   46 GAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEEKQKQAEEA 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1497 AQKSAAtqlqtkamsfsEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEqeleiwRQKANEAlrlrlQAE 1576
Cdd:TIGR02794  125 KAKQAA-----------EAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAK------KKAEAEA-----KAK 182

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1577 EEAQKKshAQEEAEKQKLEAerdAKKRGKAEEAALKQKENAEK-ELDKQRKFAEQIAQQKLSAEQE 1641
Cdd:TIGR02794  183 AEAEAK--AKAEEAKAKAEA---AKAKAAAEAAAKAEAEAAAAaAAEAERKADEAELGDIFGLASG 243
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1838-2506 4.16e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 69.71  E-value: 4.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1838 NIVEETLKQKKVVEEEIHIIKinFHKASKEKADLESELKKLKgiadETQKSKLKAEEEAEKLKKlaaEEERRRKEAEEKV 1917
Cdd:PRK03918   139 AILESDESREKVVRQILGLDD--YENAYKNLGEVIKEIKRRI----ERLEKFIKRTENIEELIK---EKEKELEEVLREI 209

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1918 KRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDV--LSKNKEDVLAQE 1995
Cdd:PRK03918   210 NEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIeeLEEKVKELKELK 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1996 KLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKeaEEEAARRAAAEAAAL 2075
Cdd:PRK03918   290 EKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEK--RLEELEERHELYEEA 367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQqadAEMSKHKKEAEqalqqksqvEKELTVVKLQLDETDKQKVLLDQELQRVKGEvndafkqKSQVEVELARVRIQM 2155
Cdd:PRK03918   368 KAKK---EELERLKKRLT---------GLTPEKLEKELEELEKAKEEIEEEISKITAR-------IGELKKEIKELKKAI 428

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2156 EELVKLKLKIEEENRRLMQKDKdstQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRAL-AEKILKEKM 2234
Cdd:PRK03918   429 EELKKAKGKCPVCGRELTEEHR---KELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELiKLKELAEQL 505

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2235 QAIQEATKlKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDketegfqkslEAERKRQLEASAEAEKLKLRVKELSLAQ 2314
Cdd:PRK03918   506 KELEEKLK-KYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKK----------ELEKLEELKKKLAELEKKLDELEEELAE 574

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2315 TKAEDEAKKFkKQADEVKAQLQRTEKHTTEIVVQKLETQRLQST-READDLKSAIADLeeerkklkkeaeelqRKSKEMA 2393
Cdd:PRK03918   575 LLKELEELGF-ESVEELEERLKELEPFYNEYLELKDAEKELEREeKELKKLEEELDKA---------------FEELAET 638

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2394 NAQQEQIEQQKAELQQSFLTE-----KGLLLKREKEVEGEKKRFEkQLEDEMKKAKALKDEQERQRKLMEEERKKLqaim 2468
Cdd:PRK03918   639 EKRLEELRKELEELEKKYSEEeyeelREEYLELSRELAGLRAELE-ELEKRREEIKKTLEKLKEELEEREKAKKEL---- 713

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1389908296 2469 dEAVRKQKEAEEEMKNKQREMDVLDKKR-LEQEKQLAEE 2506
Cdd:PRK03918   714 -EKLEKALERVEELREKVKKYKALLKERaLSKVGEIASE 751
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1261-1821 4.84e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 69.37  E-value: 4.84e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1261 IKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQ---MAEAHAKSVAKAEQEALELKMK----MKEEASKRQD 1333
Cdd:pfam05483  259 LTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEdikMSLQRSMSTQKALEEDLQIATKticqLTEEKEAQME 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1334 VAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAE 1413
Cdd:pfam05483  339 ELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDE 418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1414 KLrkaaQDEAERLRKqVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQaeEAERRMKQAEEEKIRQIrvv 1493
Cdd:pfam05483  419 KL----LDEKKQFEK-IAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLK--EVEDLKTELEKEKLKNI--- 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1494 eEVAQKSAATQLQTKAMsfSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKanealrLRL 1573
Cdd:pfam05483  489 -ELTAHCDKLLLENKEL--TQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREE------FIQ 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1574 QAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAAlkqkENAEKELDKQRKFAEQIAQqklsaeqecirlkadfehae 1653
Cdd:pfam05483  560 KGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKNKNIEELHQ-------------------- 615

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1654 qqrglldnELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQM---KINAEKASMVNTEKSKQLLESEALKMKQLADEA 1730
Cdd:pfam05483  616 --------ENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKfeeIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEA 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1731 ARMRSVAEEaKKQRQIAEEEA--ARQRSEAEKILKEKLAAI-------NEATRLKTEAEMALKAKEAENERLKRQAEEEA 1801
Cdd:pfam05483  688 VKLQKEIDK-RCQHKIAEMVAlmEKHKHQYDKIIEERDSELglyknkeQEQSSAKAALEIELSNIKAELLSLKKQLEIEK 766

                          570       580
                   ....*....|....*....|
gi 1389908296 1802 YQRKLLEDQAAQHKQDIEEK 1821
Cdd:pfam05483  767 EEKEKLKMEAKENTAILKDK 786
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 2181-2521 5.89e-11

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 69.00  E-value: 5.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2181 QKLLAEEAEKMKSLAEEAGRLSVEAEETARQ----RQIAESNLAEQRALAEKilkEKMQAIQE--ATKLKAEAEKLQKQK 2254
Cdd:pfam17380  281 QKAVSERQQQEKFEKMEQERLRQEKEEKAREverrRKLEEAEKARQAEMDRQ---AAIYAEQErmAMERERELERIRQEE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2255 DQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQ-LEAsaeAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKA 2333
Cdd:pfam17380  358 RKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQeLEA---ARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQ 434

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2334 QLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEerkklkkeaeelqrKSKEManaQQEQIEQQKAELQQSFLT 2413
Cdd:pfam17380  435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKR--------------KKLEL---EKEKRDRKRAEEQRRKIL 497

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2414 EKGLLLKREKEVEGEKKRfeKQLEDEMKKAKALKDEQERQRKLMEEERKKLQaiMDEAVRKQKEAEEEMKNKQReMDVLD 2493
Cdd:pfam17380  498 EKELEERKQAMIEEERKR--KLLEKEMEERQKAIYEEERRREAEEERRKQQE--MEERRRIQEQMRKATEERSR-LEAME 572

                          330       340
                   ....*....|....*....|....*...
gi 1389908296 2494 KKRlEQEKQLAEENKKLREQLQTFEISS 2521
Cdd:pfam17380  573 RER-EMMRQIVESEKARAEYEATTPITT 599
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1650-2346 5.96e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.89  E-value: 5.96e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1650 EHAEQQrglLDNELQRLKNEVNSTEKQRKQLEDELNKvRSEMDSLLQMKINAEKASmVNTEKSKQLLESEalKMKQLADE 1729
Cdd:TIGR04523   32 DTEEKQ---LEKKLKTIKNELKNKEKELKNLDKNLNK-DEEKINNSNNKIKILEQQ-IKDLNDKLKKNKD--KINKLNSD 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1730 AARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEaemaLKAKEAENERLKRQAEEEAYQRKLLED 1809
Cdd:TIGR04523  105 LSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKE----LEKLNNKYNDLKKQKEELENELNLLEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1810 QaaqhKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINfHKASKEKADLESELKKLKGIADETQKSK 1889
Cdd:TIGR04523  181 E----KLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQN-NQLKDNIEKKQQEINEKTTEISNTQTQL 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1890 LKAEEEAEKLKKlaaeeerrrkeaeekvkritaaeeeaarQCKAAQEEVERLKKKAEDANKQkekaekeaekqvvLAKEA 1969
Cdd:TIGR04523  256 NQLKDEQNKIKK----------------------------QLSEKQKELEQNNKKIKELEKQ-------------LNQLK 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1970 AQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENA---------------KKLAQEAEKAKEKAEKEAALLRQKAEEAEK 2034
Cdd:TIGR04523  295 SEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQisqnnkiisqlneqiSQLKKELTNSESENSEKQRELEEKQNEIEK 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2035 QKKaaENEAAKQAKAQ-----NDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVV 2109
Cdd:TIGR04523  375 LKK--ENQSYKQEIKNlesqiNDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVK 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2110 KLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAE 2189
Cdd:TIGR04523  453 ELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESE 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2190 KMKslaeeagrlsVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEatkLKAEAEKLQKQKDQAQETAKRLQEDKQ 2269
Cdd:TIGR04523  533 KKE----------KESKISDLEDELNKDDFELKKENLEKEIDEKNKEIEE---LKQTQKSLKKKQEEKQELIDQKEKEKK 599

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2270 QIQQRLDKETEgfqksLEAERKRQLE-ASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIV 2346
Cdd:TIGR04523  600 DLIKEIEEKEK-----KISSLEKELEkAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESK 672
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3054-3092 6.66e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 59.65  E-value: 6.66e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3054 LLEAQLSTGGIVDPVKSYRIPHEVACKRGYFDDKMSKTL 3092
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1395-1644 7.18e-11

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 67.18  E-value: 7.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1395 KAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEEtQRKKNAEDELKRKSDAEKEAAKQKQRALDDlqkyKMQAEE 1474
Cdd:TIGR02794   63 AKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAE-KAAKQAEQAAKQAEEKQKQAEEAKAKQAAE----AKAKAE 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1475 AERRMKQAEEEKIRQirvvEEVAQKSAATQLQTKAmsfseqttklEESLKKEqgnvlklqeEADKLKKQQKEANTAREEA 1554
Cdd:TIGR02794  138 AEAERKAKEEAAKQA----EEEAKAKAAAEAKKKA----------EEAKKKA---------EAEAKAKAEAEAKAKAEEA 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1555 EQELEIWRQKanealrlrlqAEEEAQKKShAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQ 1634
Cdd:TIGR02794  195 KAKAEAAKAK----------AAAEAAAKA-EAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSEVDK 263

                          250
                   ....*....|
gi 1389908296 1635 KLSAEQECIR 1644
Cdd:TIGR02794  264 YAAIIQQAIQ 273
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1749-2531 7.45e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 68.93  E-value: 7.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1749 EEAA------RQRSEAEKilkeKLAAINEA-TRLkteaEMALKAKEAENERLKRQAEE-EAYQRKLLEDQAAQH---KQD 1817
Cdd:TIGR02168  162 EEAAgiskykERRKETER----KLERTRENlDRL----EDILNELERQLKSLERQAEKaERYKELKAELRELELallVLR 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1818 IEEKITQLQTSsDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAE 1897
Cdd:TIGR02168  234 LEELREELEEL-QEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1898 KLKKlaaeeerrrkeaeeKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAE 1977
Cdd:TIGR02168  313 NLER--------------QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELE 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1978 QKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQR 2057
Cdd:TIGR02168  379 EQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELER 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2058 KeaeeeaarraaaeaaalkqkQQADAEMSKHKKEAEQALQQKSQvekeltvvklQLDETDKQKVLLDQELQRVKGE---V 2134
Cdd:TIGR02168  459 L--------------------EEALEELREELEEAEQALDAAER----------ELAQLQARLDSLERLQENLEGFsegV 508

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2135 NDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQK--DKDSTQKLLAEEAEKMKSLaeeaGRLSVEAEETARQR 2212
Cdd:TIGR02168  509 KALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAvvVENLNAAKKAIAFLKQNEL----GRVTFLPLDSIKGT 584

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2213 QIaESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQ------KDQAQETAKRLQEDKQQIQQRLDKETEGFQKSL 2286
Cdd:TIGR02168  585 EI-QGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGvlvvddLDNALELAKKLRPGYRIVTLDGDLVRPGGVITG 663

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2287 EAERKRQ--LEASAEAEKLKLRVKELslaqtkaEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQStreaddl 2364
Cdd:TIGR02168  664 GSAKTNSsiLERRREIEELEEKIEEL-------EEKIAELEKALAELRKELEELEEELEQLRKELEELSRQIS------- 729

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2365 ksaiadleeerkklkkeaeeLQRKSKEMANAQQEQIEQQKAELQqsfltekglllKREKEVEGEKKRFEKQLEDEMKKAK 2444
Cdd:TIGR02168  730 --------------------ALRKDLARLEAEVEQLEERIAQLS-----------KELTELEAEIEELEERLEEAEEELA 778

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2445 ALkdeqerqrklmEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTV 2524
Cdd:TIGR02168  779 EA-----------EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847


                   ....*..
gi 1389908296 2525 SQTKESQ 2531
Cdd:TIGR02168  848 EELSEDI 854
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2075-2514 8.06e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.55  E-value: 8.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2075 LKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKvlldQELQRVKGEVNDAFKQKSQVEVELARVRIQ 2154
Cdd:PRK03918   185 IKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEV----KELEELKEEIEELEKELESLEGSKRKLEEK 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2155 MEELVKLKLKIEEENRRLMQKDKDSTQ------------KLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQ 2222
Cdd:PRK03918   261 IRELEERIEELKKEIEELEEKVKELKElkekaeeyiklsEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERL 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2223 RALAEKI---------LKEKMQAIQEATKLKAEAEKLQKQK-----DQAQETAKRLQEDKQQIQQRLDKETE--GFQKSL 2286
Cdd:PRK03918   341 EELKKKLkelekrleeLEERHELYEEAKAKKEELERLKKRLtgltpEKLEKELEELEKAKEEIEEEISKITAriGELKKE 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2287 EAERKRQLEASAEA--------------------EKLKLRVKELSLAQTKAEDEAKKFKKQADEVKA------------- 2333
Cdd:PRK03918   421 IKELKKAIEELKKAkgkcpvcgrelteehrkellEEYTAELKRIEKELKEIEEKERKLRKELRELEKvlkkeseliklke 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2334 ---QLQRTEKHTTEIVVQKLEtqrlQSTREADDLKSAIADLEEERKKLKKEAEELQ--RKSKEMANAQQEQIEQQKAELQ 2408
Cdd:PRK03918   501 laeQLKELEEKLKKYNLEELE----KKAEEYEKLKEKLIKLKGEIKSLKKELEKLEelKKKLAELEKKLDELEEELAELL 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2409 QSfLTEKGL-----LLKREKEVEGEKKRF------EKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKE 2477
Cdd:PRK03918   577 KE-LEELGFesveeLEERLKELEPFYNEYlelkdaEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKK 655

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 1389908296 2478 -AEEEMKNKQREMDVLDKKRLEQEKQLaEENKKLREQL 2514
Cdd:PRK03918   656 ySEEEYEELREEYLELSRELAGLRAEL-EELEKRREEI 692
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1387-1809 8.61e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.26  E-value: 8.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRK--QVAEETQRKKNAEDELKRKsDAEKEAAKQKQRALDD 1464
Cdd:COG4717     82 EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKllQLLPLYQELEALEAELAEL-PERLEELEERLEELRE 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1465 LQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQtkamSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQ 1544
Cdd:COG4717    161 LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE----ELQQRLAELEEELEEAQEELEELEEELEQLENEL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1545 KEANTAREEAEQE--------------------------------------LEIWRQKANEALRLRLQAEEEAQKKSHAQ 1586
Cdd:COG4717    237 EAAALEERLKEARlllliaaallallglggsllsliltiagvlflvlgllaLLFLLLAREKASLGKEAEELQALPALEEL 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1587 EEAEKQKLEAERDAKKRGKAEEA--ALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNelq 1664
Cdd:COG4717    317 EEEELEELLAALGLPPDLSPEELleLLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQ--- 393

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1665 rlKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMkinaekasmVNTEKSKQLLESEALKMKQLADEAARMRsvAEEAKKQR 1744
Cdd:COG4717    394 --AEEYQELKEELEELEEQLEELLGELEELLEA---------LDEEELEEELEELEEELEELEEELEELR--EELAELEA 460

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 1745 QIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKeaenERLKRQAEEEaYQRKLLED 1809
Cdd:COG4717    461 ELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELL----EEAREEYREE-RLPPVLER 520
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1387-1695 1.12e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 68.56  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDaEKEAAKQKQRALD--- 1463
Cdd:TIGR02169  689 ELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ-EIENVKSELKELEari 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1464 -----DLQKYKMQAEEAERRMKQAEEEKI-RQIRVVEEVAQK--SAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQE 1535
Cdd:TIGR02169  768 eeleeDLHKLEEALNDLEARLSHSRIPEIqAELSKLEEEVSRieARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKE 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1536 EADKLKKQQKEANTAREEAEQELEiwrqkanealrlRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEeaaLKQKE 1615
Cdd:TIGR02169  848 QIKSIEKEIENLNGKKEELEEELE------------ELEAALRDLESRLGDLKKERDELEAQLRELERKIEE---LEAQI 912

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1616 NAEKELDKQRKFAEQIAQQKLS-------AEQECIRLKADFEHAEQQRGLLDNELQRLK-------NEVNSTEKQRKQLE 1681
Cdd:TIGR02169  913 EKKRKRLSELKAKLEALEEELSeiedpkgEDEEIPEEELSLEDVQAELQRVEEEIRALEpvnmlaiQEYEEVLKRLDELK 992

                          330
                   ....*....|....
gi 1389908296 1682 DELNKVRSEMDSLL 1695
Cdd:TIGR02169  993 EKRAKLEEERKAIL 1006
CH_SpAIN1-like_rpt2 cd21291
second calponin homology (CH) domain found in Schizosaccharomyces pombe alpha-actinin-like ...
 111-168 1.19e-10

second calponin homology (CH) domain found in Schizosaccharomyces pombe alpha-actinin-like protein 1 and similar proteins; Schizosaccharomyces pombe alpha-actinin-like protein 1 (SpAIN1) binds to actin and is involved in actin-ring formation and organization. It plays a role in cytokinesis and is involved in septation. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409140  Cd Length: 115  Bit Score: 61.78  E-value: 1.19e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDV-DVPHPDEKSIITYVSSLY 168
Cdd:cd21291     53 PDLIDYDKLDKKDHRGNMQLAFDIASKEIGIPQLLDVEDVcDVAKPDERSIMTYVAYYF 111
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1596-1829 1.33e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 66.71  E-value: 1.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1596 AERDAKKRGKAE-EAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTE 1674
Cdd:COG4942     17 AQADAAAEAEAElEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1675 KQRKQLEDELNKVrseMDSLLQMKINAEKASMVNTEKSKQLLESEALkMKQLADeaARMRSVAEEAKKQRQIAE--EEAA 1752
Cdd:COG4942     97 AELEAQKEELAEL---LRALYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAP--ARREQAEELRADLAELAAlrAELE 170

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1753 RQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSS 1829
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
PLEC smart00250
Plectin repeat;
4229-4266 1.44e-10

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 58.65  E-value: 1.44e-10
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4229 QRLLEAQACTGGIIDPNTGEKFSVVDAMNKGLVDKIMV 4266
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1164-1901 1.56e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 68.15  E-value: 1.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1164 PISDSRALREQLTD---EKKLLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYKALQDPIASplkKPKMECASDDII 1240
Cdd:TIGR00606  164 PLSEGKALKQKFDEifsATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITS---KEAQLESSREIV 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVN----LRTRYSELMTLTNQYIKfIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQ-KQMAEAHAKSVAKAEQ 1315
Cdd:TIGR00606  241 KSYENeldpLKNRLKEIEHNLSKIMK-LDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQlNDLYHNHQRTVREKER 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1316 EALELKMKMKEEASKRQDVaaDAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHK 1395
Cdd:TIGR00606  320 ELVDCQRELEKLNKERRLL--NQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHT 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1396 AKSEAElqelRDRAAEAEKLRKAAQDEaERLRKQVAEETQRKKNAedeLKRKSDAEKEAAKQKQRALDDLQKYKMQAEEA 1475
Cdd:TIGR00606  398 LVIERQ----EDEAKTAAQLCADLQSK-ERLKQEQADEIRDEKKG---LGRTIELKKEILEKKQEELKFVIKELQQLEGS 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1476 ERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQkeaNTAREEAE 1555
Cdd:TIGR00606  470 SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQME---MLTKDKMD 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1556 QELEIWRQKANEALRLRLQAEEEAQKKS-----HAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQR-KFAE 1629
Cdd:TIGR00606  547 KDEQIRKIKSRHSDELTSLLGYFPNKKQledwlHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLsSYED 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1630 QIAQQKLSAEQECI--RLKADFEHAEQQRGLL-------------------------------DNELQ----RLKNEVNS 1672
Cdd:TIGR00606  627 KLFDVCGSQDEESDleRLKEEIEKSSKQRAMLagatavysqfitqltdenqsccpvcqrvfqtEAELQefisDLQSKLRL 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1673 TEKQRKQLEDELNKVRSEMDSLLqmkINAEKASMVNTEKSKQLLESEAlKMKQLADEAARMRSVAEEAKKQRQ--IAEEE 1750
Cdd:TIGR00606  707 APDKLKSTESELKKKEKRRDEML---GLAPGRQSIIDLKEKEIPELRN-KLQKVNRDIQRLKNDIEEQETLLGtiMPEEE 782

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1751 AAR--------------QRSEAEKILkEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQhKQ 1816
Cdd:TIGR00606  783 SAKvcltdvtimerfqmELKDVERKI-AQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQ-IQ 860

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1817 DIEEKITQLQT---SSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAE 1893
Cdd:TIGR00606  861 HLKSKTNELKSeklQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQ 940


                   ....*...
gi 1389908296 1894 EEAEKLKK 1901
Cdd:TIGR00606  941 DKVNDIKE 948
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1403-1848 1.57e-10

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 67.77  E-value: 1.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1403 QELRDraAEAEKlrKAAQDEaerlrkqVAEETQRKKNAEDElkRKSDAEKeaAKQKQRALDDLQKYKMQAeeaeRRMKQA 1482
Cdd:PRK10929    30 QELEQ--AKAAK--TPAQAE-------IVEALQSALNWLEE--RKGSLER--AKQYQQVIDNFPKLSAEL----RQQLNN 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1483 EEEKIRQIRvveevaQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQeleiwr 1562
Cdd:PRK10929    91 ERDEPRSVP------PNMSTDALEQEILQVSSQLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIER------ 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1563 qkanealrlRLQAeeeAQKKSHAQEEAEKQKLeaerdakkrgKAEEAALKQKENaekELDkqrkfaeqIAQqkLSA--EQ 1640
Cdd:PRK10929   159 ---------RLQT---LGTPNTPLAQAQLTAL----------QAESAALKALVD---ELE--------LAQ--LSAnnRQ 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1641 ECIRLKADFEHAEQQRglLDNELQRLKNEVNStekQRKQledelnkvrsemdsllqmkiNAEKAsmvnTEKSKQLLESEA 1720
Cdd:PRK10929   204 ELARLRSELAKKRSQQ--LDAYLQALRNQLNS---QRQR--------------------EAERA----LESTELLAEQSG 254

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1721 LKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKIL--KEKLAAINEATRLKTEAEM---ALKAKEA------E 1789
Cdd:PRK10929   255 DLPKSIVAQFKINRELSQALNQQAQRMDLIASQQRQAASQTLqvRQALNTLREQSQWLGVSNAlgeALRAQVArlpempK 334

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1790 NERLKRQAEEEAYQRKLLEDQAAQHKQDieekiTQLQTSSDSEL-GRQKNIVEETLKQKK 1848
Cdd:PRK10929   335 PQQLDTEMAQLRVQRLRYEDLLNKQPQL-----RQIRQADGQPLtAEQNRILDAQLRTQR 389
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2084-2512 1.71e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.78  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2084 EMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSqvevELARVRIQMEELVKLKL 2163
Cdd:PRK03918   173 EIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK----ELEELKEEIEELEKELE 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2164 KIEEENRRLMQKDKDsTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAEsnlaeqraLAEKILKEKMQAIQEATKL 2243
Cdd:PRK03918   249 SLEGSKRKLEEKIRE-LEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSE--------FYEEYLDELREIEKRLSRL 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2244 KAEAEKLQKQKDQAQETAKRLQEDKQQIQQrLDKETEGFQKSLEA-ERKRQLEAsaEAEKLKLRVKELSLAQTKAE-DEA 2321
Cdd:PRK03918   320 EEEINGIEERIKELEEKEERLEELKKKLKE-LEKRLEELEERHELyEEAKAKKE--ELERLKKRLTGLTPEKLEKElEEL 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2322 KKFKKQ-ADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQqEQI 2400
Cdd:PRK03918   397 EKAKEEiEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEIE-EKE 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2401 EQQKAELqqsflTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAE- 2479
Cdd:PRK03918   476 RKLRKEL-----RELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEk 550

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1389908296 2480 -EEMKNKQREmdvLDKKRLEQEKQLAEENKKLRE 2512
Cdd:PRK03918   551 lEELKKKLAE---LEKKLDELEEELAELLKELEE 581
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1865-2516 1.80e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 67.69  E-value: 1.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1865 SKEKADLESELKKL---KGIADETQKSKLKAEEEAEKLKK---LAAEEERRRKEAEEKVKRITAAE----EEAARQCKAA 1934
Cdd:TIGR00618  162 SKEKKELLMNLFPLdqyTQLALMEFAKKKSLHGKAELLTLrsqLLTLCTPCMPDTYHERKQVLEKElkhlREALQQTQQS 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1935 QEEVERLKKKAEDANKQKEkaekeaekqvvLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRdEFENAKKLAQEAEKA 2014
Cdd:TIGR00618  242 HAYLTQKREAQEEQLKKQQ-----------LLKQLRARIEELRAQEAVLEETQERINRARKAAP-LAAHIKAVTQIEQQA 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2015 KEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQ 2094
Cdd:TIGR00618  310 QRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKT 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2095 ALQQKSQVEKELTvvkLQLDETDKQKVLLDQELQRVKGEVNDAFKQK--SQVEVELARVRIQmEELVKLKLKIEEENRrL 2172
Cdd:TIGR00618  390 TLTQKLQSLCKEL---DILQREQATIDTRTSAFRDLQGQLAHAKKQQelQQRYAELCAAAIT-CTAQCEKLEKIHLQE-S 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2173 MQKDKDSTQKLLAEEA----EKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQA-IQEATKLKAEA 2247
Cdd:TIGR00618  465 AQSLKEREQQLQTKEQihlqETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRgEQTYAQLETSE 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2248 EKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLE-AERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKK 2326
Cdd:TIGR00618  545 EDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEdIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPE 624

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAiadleEERKKLKKEAEELQRKSKEMANaQQEQIEQQKAE 2406
Cdd:TIGR00618  625 QDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHAL-----SIRVLPKELLASRQLALQKMQS-EKEQLTYWKEM 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2407 LQQsflteKGLLLKREKEVEGEKKRFEKQLEDEMKKAKA-----LKDEQERQRKLMEEERKKLQAimdeavrkqKEAEEE 2481
Cdd:TIGR00618  699 LAQ-----CQTLLRELETHIEEYDREFNEIENASSSLGSdlaarEDALNQSLKELMHQARTVLKA---------RTEAHF 764

                          650       660       670
                   ....*....|....*....|....*....|....*
gi 1389908296 2482 MKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQT 2516
Cdd:TIGR00618  765 NNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTH 799
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1440-1699 1.82e-10

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 66.02  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1440 AEDELKRKSDAEKEAAKQKQRALDDLQKykmQAEEAERRmKQAEEEKIRQIRvveevaQKSAAtqlqtkamsfsEQTTKL 1519
Cdd:TIGR02794   48 VAQQANRIQQQKKPAAKKEQERQKKLEQ---QAEEAEKQ-RAAEQARQKELE------QRAAA-----------EKAAKQ 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQgnvLKLQEEADKLKKQQKEANTAREEAEQEleiwRQKANEALRlrlQAEEEAQKKshAQEEAEKQKLEAERD 1599
Cdd:TIGR02794  107 AEQAAKQA---EEKQKQAEEAKAKQAAEAKAKAEAEAE----RKAKEEAAK---QAEEEAKAK--AAAEAKKKAEEAKKK 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1600 AKKRGKAEEAALKQK--ENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQR 1677
Cdd:TIGR02794  175 AEAEAKAKAEAEAKAkaEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARG 254

                          250       260
                   ....*....|....*....|..
gi 1389908296 1678 KQLEDELNKVRSEMDSLLQMKI 1699
Cdd:TIGR02794  255 AAAGSEVDKYAAIIQQAIQQNL 276
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3885-3923 1.97e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 58.49  E-value: 1.97e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3885 LLEAQAATGYVIDPIKNLKLNVTEAVKMGIVGTEFKDKL 3923
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 2099-2529 2.08e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 67.44  E-value: 2.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2099 KSQVEKELTVVKLQLDETDKQKVLLDQELQRvkgEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKD 2178
Cdd:pfam05483  203 RVQAENARLEMHFKLKEDHEKIQHLEEEYKK---EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKL 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2179 STQKLlAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQkdqAQ 2258
Cdd:pfam05483  280 QDENL-KELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTE---FE 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2259 ETAKRLQEDKQQIQQRLDKETEGFQ--------KSLEAERKRQLEASAEAEKLKLrvKELSLAQTKAEDEAKKFKKQADE 2330
Cdd:pfam05483  356 ATTCSLEELLRTEQQRLEKNEDQLKiitmelqkKSSELEEMTKFKNNKEVELEEL--KKILAEDEKLLDEKKQFEKIAEE 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2331 VKA---------QLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEerkklkkeaeelqRKSKEMANAQQEQIE 2401
Cdd:pfam05483  434 LKGkeqelifllQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKL-------------KNIELTAHCDKLLLE 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2402 QQKAELQQSFLTekgLLLKREKE----VEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKE 2477
Cdd:pfam05483  501 NKELTQEASDMT---LELKKHQEdiinCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARS 577

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2478 AEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLRE-QLQTFEISSKTVSQTKE 2529
Cdd:pfam05483  578 IEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEElHQENKALKKKGSAENKQ 630
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 1389-1640 2.29e-10

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 66.90  E-value: 2.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1389 EKTTAHKAKS--EAELQEL-RDRAAEAEKLRKAAQDEAERLRKQVAEetqrkknAEDELKRKSDAEKEAAKQKQRALDDl 1465
Cdd:PRK05035   444 EKKKAEEAKArfEARQARLeREKAAREARHKKAAEARAAKDKDAVAA-------ALARVKAKKAAATQPIVIKAGARPD- 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1466 QKYKMQAEEAERRMKQAEEEKIRQirvVEEVAQKSAA-------TQLQTKAMSFSEQTTKLEESLKKEQgnVLKLQEEAd 1538
Cdd:PRK05035   516 NSAVIAAREARKAQARARQAEKQA---AAAADPKKAAvaaaiarAKAKKAAQQAANAEAEEEVDPKKAA--VAAAIARA- 589

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1539 KLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAE 1618
Cdd:PRK05035   590 KAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAKARKAAQQQANAEP 669

                          250       260
                   ....*....|....*....|....*.
gi 1389908296 1619 KELDKQRK--FAEQIA--QQKLSAEQ 1640
Cdd:PRK05035   670 EEAEDPKKaaVAAAIAraKAKKAAQQ 695
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2076-2526 2.42e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.97  E-value: 2.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVevelarvriqM 2155
Cdd:TIGR04523  239 QEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQD----------W 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2156 EELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQrqiaesnLAEQRALAEKILKEKMQ 2235
Cdd:TIGR04523  309 NKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRE-------LEEKQNEIEKLKKENQS 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2236 AIQEATKLKAEAEKLQKQKDQAQETAkrlqedkqqiqQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQT 2315
Cdd:TIGR04523  382 YKQEIKNLESQINDLESKIQNQEKLN-----------QQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDS 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2316 KAEDEAKKFKKQADEVKAQLQrtekhTTEIVVQKLETQRLQSTREADDLKSAIadleeerkklkkeaeelqrkskEMANA 2395
Cdd:TIGR04523  451 VKELIIKNLDNTRESLETQLK-----VLSRSINKIKQNLEQKQKELKSKEKEL----------------------KKLNE 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2396 QQEQIEQQKAELQQsfltEKGLLLKREKEVEGEKKRFEKQLEDemKKAKALKDEQERQRKLMEEERKKLQaimdEAVRKQ 2475
Cdd:TIGR04523  504 EKKELEEKVKDLTK----KISSLKEKIEKLESEKKEKESKISD--LEDELNKDDFELKKENLEKEIDEKN----KEIEEL 573

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 2476 KEAEEEMKNKQREMDvldkkrlEQEKQLAEENKKLREQLQTFEISSKTVSQ 2526
Cdd:TIGR04523  574 KQTQKSLKKKQEEKQ-------ELIDQKEKEKKDLIKEIEEKEKKISSLEK 617
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2075-2518 2.46e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.71  E-value: 2.46e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2075 LKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVkgevnDAFKQKSQVEVELARVRIQ 2154
Cdd:COG4717     73 LKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL-----PLYQELEALEAELAELPER 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2155 MEELvklKLKIEEENRRLMQKDKdstqkLLAEEAEKMKSLAEEAGRLSVEAEETARQrqiaesnLAEQRalaEKILKEKM 2234
Cdd:COG4717    148 LEEL---EERLEELRELEEELEE-----LEAELAELQEELEELLEQLSLATEEELQD-------LAEEL---EELQQRLA 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2235 QAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAE-AEKLKLRVKELSLA 2313
Cdd:COG4717    210 ELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTiAGVLFLVLGLLALL 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2314 QTKAEDEAKKFKKQADEVKAQLQRtekhtteivvQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMA 2393
Cdd:COG4717    290 FLLLAREKASLGKEAEELQALPAL----------EELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEEL 359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2394 NAQ--QEQIEQQKAELQQSF-------LTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRklMEEERKKL 2464
Cdd:COG4717    360 EEElqLEELEQEIAALLAEAgvedeeeLRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEE--LEEELEEL 437

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2465 QAimdeavrKQKEAEEEMKNKQREmdvldKKRLEQEKQLAEENKKLREQLQTFE 2518
Cdd:COG4717    438 EE-------ELEELEEELEELREE-----LAELEAELEQLEEDGELAELLQELE 479
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 442-631 2.49e-10

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 63.23  E-value: 2.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  442 LRYTQDLLGWVEENQRRVDEGEWGSDLPTVESLLGSHRGLHQCVEEFRSKIERAKADESQV---SPASKAAYRDYLGKLE 518
Cdd:cd00176      6 LRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLieeGHPDAEEIQERLEELN 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  519 LQYGKLLTSSKARLRYLD---QLHAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAV 595
Cdd:cd00176     86 QRWEELRELAEERRQRLEealDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSL 165

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1389908296  596 QTTGDKLLRDGHP-ARKTIEAFTAALQTQWSWLLQLC 631
Cdd:cd00176    166 NELAEELLEEGHPdADEEIEEKLEELNERWEELLELA 202
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1436-2058 2.86e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.97  E-value: 2.86e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1436 RKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEaerrMKQAEEEKIRQIRvVEEVAQKSAATQLQTKAMSFSEQ 1515
Cdd:TIGR04523   30 KQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEE----KINNSNNKIKILE-QQIKDLNDKLKKNKDKINKLNSD 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1516 TTKLEESLKKEQGNVLKLQEEADKLKKQQKEANtareeaEQELEIwrqkANEALRLrlqaEEEAQKKSHAQEEAEKQKLE 1595
Cdd:TIGR04523  105 LSKINSEIKNDKEQKNKLEVELNKLEKQKKENK------KNIDKF----LTEIKKK----EKELEKLNNKYNDLKKQKEE 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1596 AERDAKKrgkaeeaALKQKENAEKELDKQRKfAEQIAQQKLSAEQECIR----LKADFEHAEQQRGLLDN-------ELQ 1664
Cdd:TIGR04523  171 LENELNL-------LEKEKLNIQKNIDKIKN-KLLKLELLLSNLKKKIQknksLESQISELKKQNNQLKDniekkqqEIN 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1665 RLKNEVNSTEKQRKQLEDELNKVRSEMDSlLQMKINAEKASMVNTEKSKQLLESEALKMKQLAdEAARMRSVAEEAKKQR 1744
Cdd:TIGR04523  243 EKTTEISNTQTQLNQLKDEQNKIKKQLSE-KQKELEQNNKKIKELEKQLNQLKSEISDLNNQK-EQDWNKELKSELKNQE 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1745 qiaeeeaaRQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQ 1824
Cdd:TIGR04523  321 --------KKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQ 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1825 -----LQTSSDSELGRQKNIVEETLKQ-KKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEK 1898
Cdd:TIGR04523  393 indleSKIQNQEKLNQQKDEQIKKLQQeKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKV 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1899 LKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKaekeaekqvvLAKEAAQKCTAAEQ 1978
Cdd:TIGR04523  473 LSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEK----------LESEKKEKESKISD 542

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1979 KAQDVLSKNkeDVLAQEKLRDEF----ENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTE 2054
Cdd:TIGR04523  543 LEDELNKDD--FELKKENLEKEIdeknKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELE 620


                   ....
gi 1389908296 2055 KQRK 2058
Cdd:TIGR04523  621 KAKK 624
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2103-2522 2.91e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.58  E-value: 2.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2103 EKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLmqkdkdstQK 2182
Cdd:TIGR04523   81 EQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKK--------EK 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2183 LLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAE---QRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQE 2259
Cdd:TIGR04523  153 ELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKiknKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKD 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2260 TAKRLQEDKQQIQQRLDKETEGFQ--KSLEAERKRQLEA-SAEAEKLKLRVKELS--LAQTKAEDEAKKFKKQAD---EV 2331
Cdd:TIGR04523  233 NIEKKQQEINEKTTEISNTQTQLNqlKDEQNKIKKQLSEkQKELEQNNKKIKELEkqLNQLKSEISDLNNQKEQDwnkEL 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2332 KAQLQRTEKHTTEIvvqklETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEmanaQQEQIEQQKAElQQSF 2411
Cdd:TIGR04523  313 KSELKNQEKKLEEI-----QNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEE----KQNEIEKLKKE-NQSY 382

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2412 LTEKGLLLKREKEVEGE---KKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNkqre 2488
Cdd:TIGR04523  383 KQEIKNLESQINDLESKiqnQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKN---- 458

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1389908296 2489 mdvLDKKRLEQEKQLAEENKKLREQLQTFEISSK 2522
Cdd:TIGR04523  459 ---LDNTRESLETQLKVLSRSINKIKQNLEQKQK 489
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1402-1622 2.99e-10

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 65.60  E-value: 2.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1402 LQELRDRAAEAEKLR-KAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDlQKykmQAEEAERRMK 1480
Cdd:PRK09510    67 QQQQQKSAKRAEEQRkKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALK-QK---QAEEAAAKAA 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1481 QAEEEKIRQIRVVEEVAQKSAAtqlqtkamsfseqttklEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEqelei 1560
Cdd:PRK09510   143 AAAKAKAEAEAKRAAAAAKKAA-----------------AEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAK----- 200

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 1561 wrQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELD 1622
Cdd:PRK09510   201 --KKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVD 260
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1446-1890 3.25e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.33  E-value: 3.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1446 RKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKK 1525
Cdd:COG4717     64 RKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAE 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1526 EQGNVLKLQEEADKLKKQQKEantaREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGK 1605
Cdd:COG4717    144 LPERLEELEERLEELRELEEE----LEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1606 AEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRL------KADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQ 1679
Cdd:COG4717    220 EELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLallglgGSLLSLILTIAGVLFLVLGLLALLFLLLAREKAS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1680 LEDELNKVR--SEMDSLLQMKINAEKAS-MVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEA--ARQ 1754
Cdd:COG4717    300 LGKEAEELQalPALEELEEEELEELLAAlGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAllAEA 379

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1755 RSEAEKILKEKLAAINEATRLK---TEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQhkQDIEEKITQLQTssds 1831
Cdd:COG4717    380 GVEDEEELRAALEQAEEYQELKeelEELEEQLEELLGELEELLEALDEEELEEELEELEEEL--EELEEELEELRE---- 453

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1832 ELGRQKNIVEETLKQKKVVE--EEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKL 1890
Cdd:COG4717    454 ELAELEAELEQLEEDGELAEllQELEELKAELRELAEEWAALKLALELLEEAREEYREERL 514
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1830-2518 7.34e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.86  E-value: 7.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1830 DSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLEsELKKLKGIADETQ-----KSKLKAEEEAEKLKK--- 1901
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAE-RYQALLKEKREYEgyellKEKEALERQKEAIERqla 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1902 -LAAEEERRRKEAEEKVKRITAAE----EEAARQCKAAQEEVERLKKKAEDankqKEKAEKEAEKQVVLAKEAAQKCTAA 1976
Cdd:TIGR02169  248 sLEEELEKLTEEISELEKRLEEIEqlleELNKKIKDLGEEEQLRVKEKIGE----LEAEIASLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1977 EQKAQDVLSKNKEDVlaqEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQ 2056
Cdd:TIGR02169  324 LAKLEAEIDKLLAEI---EELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKRE 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2057 RkeaeeeaARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKL-------QLDETDKQKVLLDQELQR 2129
Cdd:TIGR02169  401 I-------NELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALeikkqewKLEQLAADLSKYEQELYD 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2130 VKGEVNDAFKQKSQVEVELARV---RIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAG-RLS--- 2202
Cdd:TIGR02169  474 LKEEYDRVEKELSKLQRELAEAeaqARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGnRLNnvv 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2203 VEAEETA-------RQRQIAE----------------------------------------------------SNLAEQR 2223
Cdd:TIGR02169  554 VEDDAVAkeaiellKRRKAGRatflplnkmrderrdlsilsedgvigfavdlvefdpkyepafkyvfgdtlvvEDIEAAR 633

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2224 ALAEKI--------LKEKMQAI-----------QEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLD-------- 2276
Cdd:TIGR02169  634 RLMGKYrmvtlegeLFEKSGAMtggsraprggiLFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDelsqelsd 713

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2277 --KETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQR 2354
Cdd:TIGR02169  714 asRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRI 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2355 LQSTREADDLK------SAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEgE 2428
Cdd:TIGR02169  794 PEIQAELSKLEeevsriEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE-E 872

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2429 KKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQE-------- 2500
Cdd:TIGR02169  873 LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEeipeeels 952

                          810
                   ....*....|....*....
gi 1389908296 2501 -KQLAEENKKLREQLQTFE 2518
Cdd:TIGR02169  953 lEDVQAELQRVEEEIRALE 971
CH_MICALL1 cd21252
calponin homology (CH) domain found in MICAL-like protein 1; MICAL-like protein 1 (MICAL-L1), ...
 111-168 7.44e-10

calponin homology (CH) domain found in MICAL-like protein 1; MICAL-like protein 1 (MICAL-L1), also called molecule interacting with Rab13 (MIRab13), is a probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. It is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. It may be involved in a late step of receptor-mediated endocytosis regulating endocytosed-EGF receptor trafficking. Alternatively, it may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. MICAL-L1 may indirectly play a role in neurite outgrowth. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409101  Cd Length: 107  Bit Score: 59.11  E-value: 7.44e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21252     43 PDLIDFDSLSKDNVYENNRLAFEVAERELGIPALLDPEDmVSMKVPDCLSIMTYVSQYY 101
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 2084-2515 9.54e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 65.38  E-value: 9.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2084 EMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKL 2163
Cdd:TIGR00618  160 AKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQ 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2164 KIEEENRRL--MQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAEsnLAEQRALAEKILKEKMQAIQEAT 2241
Cdd:TIGR00618  240 QSHAYLTQKreAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAP--LAAHIKAVTQIEQQAQRIHTELQ 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2242 KLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRqlEASAEAEKLKLRVKELSLAQTKAEDE- 2320
Cdd:TIGR00618  318 SKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIR--EISCQQHTLTQHIHTLQQQKTTLTQKl 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2321 ----AKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMAN-- 2394
Cdd:TIGR00618  396 qslcKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQql 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2395 AQQEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFE-----------------------KQLEDEMKKAKALKDEQE 2451
Cdd:TIGR00618  476 QTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNparqdidnpgpltrrmqrgeqtyAQLETSEEDVYHQLTSER 555

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2452 RQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDK---KRLEQEKQLAEENKKLREQLQ 2515
Cdd:TIGR00618  556 KQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDlteKLSEAEDMLACEQHALLRKLQ 622
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1415-1826 9.85e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.79  E-value: 9.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1415 LRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVE 1494
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1495 EVAQKSAATQLQTKAMSFSEQTTKLEESLKKeqgnvlkLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRlRLQ 1574
Cdd:COG4717    127 LLPLYQELEALEAELAELPERLEELEERLEE-------LRELEEELEELEAELAELQEELEELLEQLSLATEEELQ-DLA 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1575 AEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIA---------------------- 1632
Cdd:COG4717    199 EELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAallallglggsllsliltiagv 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1633 ------------QQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVN-STEKQRKQLEDELNKVRSEMDSLLQMKI 1699
Cdd:COG4717    279 lflvlgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGlPPDLSPEELLELLDRIEELQELLREAEE 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1700 NAEKASMVNTEKSKQLLeseaLKMKQLADEAArMRSVAEEAKKQRQIAEE--EAARQRSEAEKILKEKLAAINEATRLKT 1777
Cdd:COG4717    359 LEEELQLEELEQEIAAL----LAEAGVEDEEE-LRAALEQAEEYQELKEEleELEEQLEELLGELEELLEALDEEELEEE 433

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1778 EAEMALKAKEAENER---LKRQAEEEAYQRKLLEDQAAQH-KQDIEEKITQLQ 1826
Cdd:COG4717    434 LEELEEELEELEEELeelREELAELEAELEQLEEDGELAElLQELEELKAELR 486
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 2181-2502 1.16e-09

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 63.40  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2181 QKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQET 2260
Cdd:pfam13868   34 IKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEE 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2261 AKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEklkLRVKELSLAQTKAEDEAKKFKKQADEVKaqlqrtEK 2340
Cdd:pfam13868  114 DQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREED---ERILEYLKEKAEREEEREAEREEIEEEK------ER 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2341 HTTEIVVQKLETQRLQSTREADDLKSAIADLeeerkklkkeaeelQRKSKEMANAQQEQIEQQKAELQQSFLTEKGL-LL 2419
Cdd:pfam13868  185 EIARLRAQQEKAQDEKAERDELRAKLYQEEQ--------------ERKERQKEREEAEKKARQRQELQQAREEQIELkER 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2420 KREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDE---AVRKQKEAEEEMKNKQREMDVLDKKR 2496
Cdd:pfam13868  251 RLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEEreeQRAAEREEELEEGERLREEEAERRER 330


                   ....*.
gi 1389908296 2497 LEQEKQ 2502
Cdd:pfam13868  331 IEEERQ 336
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1456-1879 1.27e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.68  E-value: 1.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1456 KQKQRALDDL------QKYKMQAEEAE---RRMKQAEEEKIRQIRvvEEVAQKSAA------TQLQTKAMSFSEQTTKLE 1520
Cdd:PRK02224   149 SDRQDMIDDLlqlgklEEYRERASDARlgvERVLSDQRGSLDQLK--AQIEEKEEKdlherlNGLESELAELDEEIERYE 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1521 EslKKEQGNVLKlqEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDA 1600
Cdd:PRK02224   227 E--QREQARETR--DEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1601 KKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQL 1680
Cdd:PRK02224   303 GLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDR 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1681 EDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEE----------- 1749
Cdd:PRK02224   383 REEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAgkcpecgqpve 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1750 -----EAARQRSEAEKILKEKLAAINEA-TRLKTEAEMALKAKEAEnerlkRQAEEEAYQRKLLEDQAAQHKQDIEEKIT 1823
Cdd:PRK02224   463 gsphvETIEEDRERVEELEAELEDLEEEvEEVEERLERAEDLVEAE-----DRIERLEERREDLEELIAERRETIEEKRE 537

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1824 QLQtssdsELGRQKNIVEETLKQKKVVEEEIHiikINFHKASKEKADLESELKKLK 1879
Cdd:PRK02224   538 RAE-----ELRERAAELEAEAEEKREAAAEAE---EEAEEAREEVAELNSKLAELK 585
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2152-2566 1.27e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.99  E-value: 1.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2152 RIQMEELV---KLKLKIEEENRRLMQKdKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEK 2228
Cdd:pfam02463  155 RLEIEEEAagsRLKRKKKEALKKLIEE-TENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2229 ILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAErkrqlEASAEAEKLKLRVK 2308
Cdd:pfam02463  234 LNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKE-----EEELKSELLKLERR 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2309 ELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKhttEIVVQKLETQRLQSTREADDLksaiADLEEERKKLKKEAEELQRK 2388
Cdd:pfam02463  309 KVDDEEKLKESEKEKKKAEKELKKEKEEIEEL---EKELKELEIKREAEEEEEEEL----EKLQEKLEQLEEELLAKKKL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2389 SKEMANAQQEQIEQQKAELqqsfltekgllLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQaim 2468
Cdd:pfam02463  382 ESERLSSAAKLKEEELELK-----------SEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLT--- 447

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2469 deaVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKLVAVTTVGTSK 2548
Cdd:pfam02463  448 ---EEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524

                          410
                   ....*....|....*...
gi 1389908296 2549 GVLNGSTEVDGVKKEGDS 2566
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYK 542
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
1992-2405 1.28e-09

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 64.63  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1992 LAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAE 2071
Cdd:COG5281     15 AAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAAALAEDAAAAAAA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2072 AAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARV 2151
Cdd:COG5281     95 AEAALAALAAAALALAAAALAEAALAAAAAAAAAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAALAAAAAAAAAAAAAAA 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2152 RIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILK 2231
Cdd:COG5281    175 AAAALAAASAAAAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAAASAAAQALAALAAAA 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2232 EKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRvKELS 2311
Cdd:COG5281    255 AAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQALAAAAAAAAAQLAAAAAAAAQALRAAAQ-ALAA 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2312 LAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKE 2391
Cdd:COG5281    334 LAQRALAAAALAAAAQEAALAAAAAALQAALEAAAAAAAAELAAAGDWAAGAKAALAEYADSATNVAAQVAQAATSAFSG 413

                          410
                   ....*....|....
gi 1389908296 2392 MANAQQEQIEQQKA 2405
Cdd:COG5281    414 LTDALAGAVTTGKL 427
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1388-1809 1.42e-09

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 64.26  E-value: 1.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1388 LEKTTAHKAKSEAELqelrdraaeAEKLRKAAQDEAERLRKQVAEETqrKKNAEDElKRKSDAEKEAAKQKQralDDLQK 1467
Cdd:NF033838   101 LYELNVLKEKSEAEL---------TSKTKKELDAAFEQFKKDTLEPG--KKVAEAT-KKVEEAEKKAKDQKE---EDRRN 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1468 Y--------KMQAEEAERRMKQAEEEkirqirVVEEVAQKSaatqlqtkamsfseqttKLEESLKKEQGNVLKLQEEADK 1539
Cdd:NF033838   166 YptntyktlELEIAESDVEVKKAELE------LVKEEAKEP-----------------RDEEKIKQAKAKVESKKAEATR 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1540 LKKQQkeanTAREEAEQeleiwrqkanEALRLRLQAEEEAQKKSHAQEEAEKQKleaeRDAKKRGKAEEAALKQKENAEK 1619
Cdd:NF033838   223 LEKIK----TDREKAEE----------EAKRRADAKLKEAVEKNVATSEQDKPK----RRAKRGVLGEPATPDKKENDAK 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1620 ELDKQRKfAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRlknevNSTEKQRKQLEDELNKVRSEMDSLLQMKI 1699
Cdd:NF033838   285 SSDSSVG-EETLPSPSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRR-----NYPTNTYKTLELEIAESDVKVKEAELELV 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1700 NAEKASMVNTEKSKQLLESEALKMKqladEAARMrsvaEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEA 1779
Cdd:NF033838   359 KEEAKEPRNEEKIKQAKAKVESKKA----EATRL----EKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEK 430

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1389908296 1780 EMALKAKEAENERLKR---QAEEEAYQRKLLED 1809
Cdd:NF033838   431 PAPKPEKPAEQPKAEKpadQQAEEDYARRSEEE 463
Caldesmon pfam02029
Caldesmon;
1272-1626 1.43e-09

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 64.12  E-value: 1.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1272 EDDEKASEKLKE----EERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQN-IQ 1346
Cdd:pfam02029    1 IEDEEEAARERRrrarEERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKrLQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1347 QELQHLK---------SLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRK 1417
Cdd:pfam02029   81 EALERQKefdptiadeKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1418 AAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRalddLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVA 1497
Cdd:pfam02029  161 DKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRG----HPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQER 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1498 QKSAATQLQTkamsfsEQttKLEESLKKEQGnvlKLQEEADKLKKQQkeantarEEAEQELEIWRQKANEalRLRLQAEE 1577
Cdd:pfam02029  237 EEEAEVFLEA------EQ--KLEELRRRRQE---KESEEFEKLRQKQ-------QEAELELEELKKKREE--RRKLLEEE 296

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 1578 EAQKKshaQEEAEKQKLEAERdaKKRGKAE------EAALKQKENAEKELDKQRK 1626
Cdd:pfam02029  297 EQRRK---QEEAERKLREEEE--KRRMKEEierrraEAAEKRQKLPEDSSSEGKK 346
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1266-1556 1.94e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.31  E-value: 1.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEAS--------------KR 1331
Cdd:TIGR02168  705 KELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEErleeaeeelaeaeaEI 784

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1332 QDVAADAEKQKQNIQQELQHLKSLSDQ------EIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQEL 1405
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAEltllneEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEEL 864

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1406 RDRAAEAEKLRKAAQDEaerlRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEE 1485
Cdd:TIGR02168  865 EELIEELESELEALLNE----RASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1486 KIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLE--ESLKKEQGNV--------LKLQEEADKLKKQQKEANTAREEAE 1555
Cdd:TIGR02168  941 LQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKrlENKIKELGPVnlaaieeyEELKERYDFLTAQKEDLTEAKETLE 1020


                   .
gi 1389908296 1556 Q 1556
Cdd:TIGR02168 1021 E 1021
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1284-1648 1.98e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 64.32  E-value: 1.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1284 EERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKeeaskrqdvaaDAEKQKQNIQQELQHLkslsDQEIKSK 1363
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELS-----------DASRKIGEIEKEIEQL----EQEEEKL 735

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1364 NQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAE-KLR----KAAQDEAERLRKQVAEETQRKK 1438
Cdd:TIGR02169  736 KERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEaRLShsriPEIQAELSKLEEEVSRIEARLR 815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1439 NAEDELKRKSDAEKEAAKQKQraldDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAAT--QLQTKAMSFSEQT 1516
Cdd:TIGR02169  816 EIEQKLNRLTLEKEYLEKEIQ----ELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAAlrDLESRLGDLKKER 891

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1517 TKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELeiwrqkanEALRLRLQAEEEAQKKSHAQEEAEKQKLEA 1596
Cdd:TIGR02169  892 DELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEEL--------SEIEDPKGEDEEIPEEELSLEDVQAELQRV 963

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 1597 ERDAKKRGKAEEAALKQKENAEKELDKQRKfaeqiAQQKLSAEQECIRLKAD 1648
Cdd:TIGR02169  964 EEEIRALEPVNMLAIQEYEEVLKRLDELKE-----KRAKLEEERKAILERIE 1010
CH_FLN-like_rpt2 cd21184
second calponin homology (CH) domain found in the filamin family; The filamin family includes ...
 111-166 2.74e-09

second calponin homology (CH) domain found in the filamin family; The filamin family includes filamin-A (FLN-A), filamin-B (FLN-B) and filamin-C (FLN-C). Filamins function to anchor various transmembrane proteins to the actin cytoskeleton. FLN-A is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-B is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton and may also promote orthogonal branching of actin filaments as well as link actin filaments to membrane glycoproteins. FLN-C, also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. This family also includes Drosophila melanogaster protein jitterbug (Jbug), which is an actin-meshwork organizing protein containing three copies of the CH domain. Other members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409033  Cd Length: 103  Bit Score: 57.25  E-value: 2.74e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296  111 PALIDMN-QVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSS 166
Cdd:cd21184     41 PGLIPDNeSLDKENPLENATKAMDIAEEELGIPKIITPEDMVSPNVDELSVMTYLSY 97
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1176-1884 2.98e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 2.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1176 TDEKKLLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYKalqdpiaSPLKKPKMECASDDIIQEYVNLR-TRYSELM 1254
Cdd:TIGR04523   82 QQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLE-------VELNKLEKQKKENKKNIDKFLTEiKKKEKEL 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1255 TLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMaeahAKSVAKAEQEALELKMKMKEEASKRQDV 1334
Cdd:TIGR04523  155 EKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELL----LSNLKKKIQKNKSLESQISELKKQNNQL 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1335 aadaEKQKQNIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRdraAEAEK 1414
Cdd:TIGR04523  231 ----KDNIEKKQQEINEKT----TEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLK---SEISD 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1415 LRKAAQDEaerLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVE 1494
Cdd:TIGR04523  300 LNNQKEQD---WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLK 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1495 EVAQ--KSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEalrLR 1572
Cdd:TIGR04523  377 KENQsyKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSV---KE 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1573 LQAEEEAQKKSHAQEEAEKQKLEAerdakkrgKAEEAALKQKenaEKELDKQRKFAEQIAQQKLSAEQECIRLKadfeha 1652
Cdd:TIGR04523  454 LIIKNLDNTRESLETQLKVLSRSI--------NKIKQNLEQK---QKELKSKEKELKKLNEEKKELEEKVKDLT------ 516

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1653 eQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSllqmkinaekasmVNTEKSKQLLESEALKMKQLADEAar 1732
Cdd:TIGR04523  517 -KKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKK-------------ENLEKEIDEKNKEIEELKQTQKSL-- 580

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1733 mrsvaeeAKKQRQiAEEEAARQRSEAEKILKEklaaINEATRLKTEAEMALKAKEAENERL----------KRQAEEEAY 1802
Cdd:TIGR04523  581 -------KKKQEE-KQELIDQKEKEKKDLIKE----IEEKEKKISSLEKELEKAKKENEKLssiiknikskKNKLKQEVK 648

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1803 QRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEiHIIKINFHKASKEKADLESELKKLKGIA 1882
Cdd:TIGR04523  649 QIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITR-MIRIKDLPKLEEKYKEIEKELKKLDEFS 727


                   ..
gi 1389908296 1883 DE 1884
Cdd:TIGR04523  728 KE 729
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2159-2519 3.81e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 63.16  E-value: 3.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2159 VKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQ 2238
Cdd:PRK03918   170 VIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELES 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2239 EATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQ--RLDKETEGFQKsLEAERKRQLEASAEAEKLKLRVKELSLAQTK 2316
Cdd:PRK03918   250 LEGSKRKLEEKIRELEERIEELKKEIEELEEKVKElkELKEKAEEYIK-LSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2317 AEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTR-EADDLKSAIADleeerkklkkeaeelqrKSKEMANA 2395
Cdd:PRK03918   329 RIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKeELERLKKRLTG-----------------LTPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2396 QQEQIEQQKAELQQSFLTekglLLKREKEVEGEKKRFEKQLEdEMKKAK-------ALKDEQERQRkLMEEERKKLQAIM 2468
Cdd:PRK03918   392 ELEELEKAKEEIEEEISK----ITARIGELKKEIKELKKAIE-ELKKAKgkcpvcgRELTEEHRKE-LLEEYTAELKRIE 465

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2469 DEaVRKQKEAEEEMKNKQREMD--VLDKKRLEQEKQLAEENKKLREQLQTFEI 2519
Cdd:PRK03918   466 KE-LKEIEEKERKLRKELRELEkvLKKESELIKLKELAEQLKELEEKLKKYNL 517
mukB PRK04863
chromosome partition protein MukB;
1405-1780 4.18e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 63.44  E-value: 4.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1405 LRDRAAEAEKLRKAAQDEAERL--RKQVAEETQRKKNAEDELKRKSDAEKE--------------------AAKQKQRAL 1462
Cdd:PRK04863   275 MRHANERRVHLEEALELRRELYtsRRQLAAEQYRLVEMARELAELNEAESDleqdyqaasdhlnlvqtalrQQEKIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1463 DDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQ--KSAATQL----------QTKAMSFSEQTTKLEESLKKEQGNV 1530
Cdd:PRK04863   355 ADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEevDELKSQLadyqqaldvqQTRAIQYQQAVQALERAKQLCGLPD 434

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1531 L---KLQEEADKLKKQQKEANTAREEAEQEL----EIWRQ--KANEALRlRLQAE-EEAQKKSHAQE---EAEKQKLEAE 1597
Cdd:PRK04863   435 LtadNAEDWLEEFQAKEQEATEELLSLEQKLsvaqAAHSQfeQAYQLVR-KIAGEvSRSEAWDVAREllrRLREQRHLAE 513

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1598 RDAKKRGKAEEaaLKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQR 1677
Cdd:PRK04863   514 QLQQLRMRLSE--LEQRLRQQQRAERLLAEFCKRLGKNLDDEDE---LEQLQEELEARLESLSESVSEARERRMALRQQL 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1678 KQLEDELNKVRSEMDSLLQMKinaEKASMVNTEKSKQLLESEALkmkqlaDEAarMRSVAEEAKKQRQIAEEEAARQRSE 1757
Cdd:PRK04863   589 EQLQARIQRLAARAPAWLAAQ---DALARLREQSGEEFEDSQDV------TEY--MQQLLERERELTVERDELAARKQAL 657

                          410       420
                   ....*....|....*....|...
gi 1389908296 1758 AEKILKEKLAAINEATRLKTEAE 1780
Cdd:PRK04863   658 DEEIERLSQPGGSEDPRLNALAE 680
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1273-1519 5.26e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 5.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1273 DDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEeaskRQDVAADAEKQKQNIQQELQHL 1352
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA----LEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1353 KslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQEL-RDRAAEAEKLRkAAQDEAERLRKQVA 1431
Cdd:COG4942     96 R----AELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLaPARREQAEELR-ADLAELAALRAELE 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1432 EETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKyKMQAEEAERRMKQAEEEKIRqiRVVEEVAQKSAATQLQTKAMS 1511
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEK-ELAELAAELAELQQEAEELE--ALIARLEAEAAAAAERTPAAG 247


                   ....*...
gi 1389908296 1512 FSEQTTKL 1519
Cdd:COG4942    248 FAALKGKL 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2090-2328 6.22e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.32  E-value: 6.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2090 KEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRiqmEELVKLKLKIEEen 2169
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALE---AELAELEKEIAE-- 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2170 rrlMQKDKDSTQKLLAE---EAEKMKSLAEEAGRLSVE-AEETARQRQIAESNLAEQRALAEKILKEKmqaiqeatklkA 2245
Cdd:COG4942     95 ---LRAELEAQKEELAEllrALYRLGRQPPLALLLSPEdFLDAVRRLQYLKYLAPARREQAEELRADL-----------A 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2246 EAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFK 2325
Cdd:COG4942    161 ELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240


                   ...
gi 1389908296 2326 KQA 2328
Cdd:COG4942    241 ERT 243
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 111-173 6.51e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 56.53  E-value: 6.51e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296  111 PALIDMNQVYRQSNQ--ENLEQAFSVAERELGVTK-LLDPEDVDvpHPDEKSIITYVSSLYDVMPR 173
Cdd:pfam00307   46 PGLVDKKKLNKSEFDklENINLALDVAEKKLGVPKvLIEPEDLV--EGDNKSVLTYLASLFRRFQA 109
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1473-1882 6.68e-09

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 62.08  E-value: 6.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1473 EEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTARE 1552
Cdd:pfam09731   52 GEDPPLAPKPKTFRPLQPSVVSAVTGESKEPKEEKKQVKIPRQSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEKALE 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1553 EAEQELEiwrQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAK------KRGKAEEAALKQKENAEKELDKQRK 1626
Cdd:pfam09731  132 EVLKEAI---SKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISRekatdsALQKAEALAEKLKEVINLAKQSEEE 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1627 FA-EQIAQQKLSAEQECIRLKADFEhaeqqrglldnELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLL-QMKINAEKA 1704
Cdd:pfam09731  209 AApPLLDAAPETPPKLPEHLDNVEE-----------KVEKAQSLAKLVDQYKELVASERIVFQQELVSIFpDIIPVLKED 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1705 SMVNTEKSKQLLESEALKMKQLADEAARMRsVAEEAKKQRQIAEEEAARQRSEAEKI--LKEKLAAINEATRLKTEAEMA 1782
Cdd:pfam09731  278 NLLSNDDLNSLIAHAHREIDQLSKKLAELK-KREEKHIERALEKQKEELDKLAEELSarLEEVRAADEAQLRLEFERERE 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1783 LKAKEAENE---RLKRQAEE-EAYQRKLLEDQAAQ----HKQDIEEKITQLQTSSDSELGRQK---NIVEETLKQKKVVE 1851
Cdd:pfam09731  357 EIRESYEEKlrtELERQAEAhEEHLKDVLVEQEIElqreFLQDIKEKVEEERAGRLLKLNELLanlKGLEKATSSHSEVE 436

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1389908296 1852 EE----------IHIIKINFHKAS--KEKADLESELKKLKGIA 1882
Cdd:pfam09731  437 DEnrkaqqlwlaVEALRSTLEDGSadSRPRPLVRELKALKELA 479
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1619-2510 6.77e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 62.76  E-value: 6.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1619 KELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLL---DNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLL 1695
Cdd:TIGR00606  186 KALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQItskEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIM 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1696 QM--KINAEKASMVNTEKSKQLLESEALKMKQLADEaaRMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEAT 1773
Cdd:TIGR00606  266 KLdnEIKALKSRKKQMEKDNSELELKMEKVFQGTDE--QLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKT 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1774 RLKTE-AEMALKAKEAENERLKRQAEEEAYQRKLlEDQAAQHKQDIEEKITQLQT-----SSDSELGRQKNIVE----ET 1843
Cdd:TIGR00606  344 ELLVEqGRLQLQADRHQEHIRARDSLIQSLATRL-ELDGFERGPFSERQIKNFHTlvierQEDEAKTAAQLCADlqskER 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1844 LKQKKVVEEEIHIiKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAA 1923
Cdd:TIGR00606  423 LKQEQADEIRDEK-KGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKK 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1924 EEEAARQCKAaqeEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKctaaEQKAQDVLSKNKEDVLAQEKlrdEFEN 2003
Cdd:TIGR00606  502 EVKSLQNEKA---DLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDK----DEQIRKIKSRHSDELTSLLG---YFPN 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2004 AKKLAQEAEKakekaekeaalLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQkQQADA 2083
Cdd:TIGR00606  572 KKQLEDWLHS-----------KSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGS-QDEES 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2084 EMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVkgevndaFKQKSQVEvELARVRIQMEELVKLKL 2163
Cdd:TIGR00606  640 DLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV-------FQTEAELQ-EFISDLQSKLRLAPDKL 711

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2164 KIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQralaEKILKEKMQAIQEATKL 2243
Cdd:TIGR00606  712 KSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQ----ETLLGTIMPEEESAKVC 787

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2244 KAEAEKLQKQKDQAQETAKRLQedkqqiQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKK 2323
Cdd:TIGR00606  788 LTDVTIMERFQMELKDVERKIA------QQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQH 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2324 FKKQADEVKAQlqRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEqiEQQ 2403
Cdd:TIGR00606  862 LKSKTNELKSE--KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKET--SNK 937

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2404 KAELQQSFLTEK-----GLLLKREKEVEGEKKRFEKQLEDEMKKAKA-LKDEQERQRKLMEEERKKLQAIMDEAVR---- 2473
Cdd:TIGR00606  938 KAQDKVNDIKEKvknihGYMKDIENKIQDGKDDYLKQKETELNTVNAqLEECEKHQEKINEDMRLMRQDIDTQKIQerwl 1017

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*...
gi 1389908296 2474 -----------KQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKL 2510
Cdd:TIGR00606 1018 qdnltlrkrenELKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDL 1065
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4307-4345 6.86e-09

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 53.87  E-value: 6.86e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 4307 FLEVQYLTGGLIEPDATNRVAIDEAVKKGTLDARTAQKL 4345
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1246-1600 7.51e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.39  E-value: 7.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1246 LRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMaeahaksvakaEQEALELKMKMK 1325
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSL-----------EQEIENVKSELK 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1326 EEASKRQDVAADAEKqkqnIQQELQHLK-SLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQE 1404
Cdd:TIGR02169  762 ELEARIEELEEDLHK----LEEALNDLEaRLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQE 837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1405 LRDRAAEAEKLRKAAQDEAERLRKQVAEetqrkknAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEE 1484
Cdd:TIGR02169  838 LQEQRIDLKEQIKSIEKEIENLNGKKEE-------LEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEA 910

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1485 EkirqirvVEEvaQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVlklqEEADKLKKQQKEantaREEAEQELEiwrqk 1564
Cdd:TIGR02169  911 Q-------IEK--KRKRLSELKAKLEALEEELSEIEDPKGEDEEIP----EEELSLEDVQAE----LQRVEEEIR----- 968

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1389908296 1565 ANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDA 1600
Cdd:TIGR02169  969 ALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKA 1004
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2115-2518 8.01e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 62.36  E-value: 8.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2115 ETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELvklklkieEENRRLMQKDKDSTQKLLAEEAEK---M 2191
Cdd:PRK02224   182 LSDQRGSLDQLKAQIEEKEEKDLHERLNGLESELAELDEEIERY--------EEQREQARETRDEADEVLEEHEERreeL 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2192 KSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKD----QAQETAKRLQED 2267
Cdd:PRK02224   254 ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREeledRDEELRDRLEEC 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2268 KQQIQQrldketegFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVV 2347
Cdd:PRK02224   334 RVAAQA--------HNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPV 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2348 Q--KLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQR-----------------KSKEMANAQQEQIEQQKAEL- 2407
Cdd:PRK02224   406 DlgNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagkcpecgqpvegsPHVETIEEDRERVEELEAELe 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2408 ----QQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMK 2483
Cdd:PRK02224   486 dleeEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEE 565

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1389908296 2484 NKQREMDVLDKkrLEQEKQlaeENKKLREQLQTFE 2518
Cdd:PRK02224   566 EAEEAREEVAE--LNSKLA---ELKERIESLERIR 595
CH_MICALL cd21197
calponin homology (CH) domain found in the MICAL-like protein family; The MICAL-L family ...
 93-168 8.91e-09

calponin homology (CH) domain found in the MICAL-like protein family; The MICAL-L family includes MICAL-L1 and MICAL-L2. MICAL-L1, also called molecule interacting with Rab13 (MIRab13), is a probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. It is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. It may be involved in a late step of receptor-mediated endocytosis regulating endocytosed-EGF receptor trafficking. Alternatively, it may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. MICAL-L1 may indirectly play a role in neurite outgrowth. MICAL-L2, also called junctional Rab13-binding protein (JRAB), or molecule interacting with CasL-like 2, acts as an effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecule transport to the plasma membrane, and actin cytoskeleton reorganization. It regulates the endocytic recycling of occludins, claudins, and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. Members of this family contain a single copy of CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409046  Cd Length: 105  Bit Score: 56.01  E-value: 8.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296   93 QEQAQSYRGHYVQRVTRV---------------PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPD 156
Cdd:cd21197     10 RRQCEGYPGVNITNLTSSfrdglafcailhrhrPELIDFHSLKKDNWLENNRLAFRVAETSLGIPALLDAEDmVTMHVPD 89

                           90
                   ....*....|..
gi 1389908296  157 EKSIITYVSSLY 168
Cdd:cd21197     90 RLSIITYVSQYY 101
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1461-1691 8.97e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 62.24  E-value: 8.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1461 ALDDLQKYKMQAEEAERRMKQAEEeKIRQIRVVEEVAQKSAATQlqtkamsfsEQTTKLEESlkKEQGNVLKLQEEADKL 1540
Cdd:COG4913    226 AADALVEHFDDLERAHEALEDARE-QIELLEPIRELAERYAAAR---------ERLAELEYL--RAALRLWFAQRRLELL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1541 KKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQK------ 1614
Cdd:COG4913    294 EAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALlaalgl 373

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1615 --ENAEKELDKQRkfaEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEM 1691
Cdd:COG4913    374 plPASAEEFAALR---AEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAL 449
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1266-1465 9.66e-09

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 60.98  E-value: 9.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEEERRKMAEIQ---AELDKQKQMAEAHAKSVAKAEQEALElKMKMKEEASKRQDVAADAEKQK 1342
Cdd:PRK09510    73 SAKRAEEQRKKKEQQQAEELQQKQAAEQerlKQLEKERLAAQEQKKQAEEAAKQAAL-KQKQAEEAAAKAAAAAKAKAEA 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKieeeihiiriQLEKTTAHKAKSEAElqelrdRAAEAEKLRKAAQD- 1421
Cdd:PRK09510   152 EAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKK----------KAEAEAAAKAAAEAK------KKAEAEAKKKAAAEa 215

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 1422 --EAERLRKQVAEETQRKKNAEDELKRKSDA-EKEAAKQKQRALDDL 1465
Cdd:PRK09510   216 kkKAAAEAKAAAAKAAAEAKAAAEKAAAAKAaEKAAAAKAAAEVDDL 262
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1279-1731 1.07e-08

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 61.76  E-value: 1.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1279 EKLKEEERRKMAEIQA------ELDKQ----KQMAEAHAKSVAKAEQ---------EALELKMKMKEEA-SKRQDVAADA 1338
Cdd:pfam10174  292 DQLKQELSKKESELLAlqtkleTLTNQnsdcKQHIEVLKESLTAKEQraailqtevDALRLRLEEKESFlNKKTKQLQDL 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1339 EKQKQNIQQELQHLKSLSDQE------IKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHkakSEAELQELRDRAAEA 1412
Cdd:pfam10174  372 TEEKSTLAGEIRDLKDMLDVKerkinvLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSN---TDTALTTLEEALSEK 448

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1413 EKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAekeaakqkqralddlqkykMQAEEAERrmkqaeeekirqirv 1492
Cdd:pfam10174  449 ERIIERLKEQREREDRERLEELESLKKENKDLKEKVSA-------------------LQPELTEK--------------- 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1493 veevaqKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIwrqkaneALRLR 1572
Cdd:pfam10174  495 ------ESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTNPEI-------NDRIR 561

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1573 LQAEEEAQKKshaqEEAEKQKLEAERDAKKRGKAE-EAALKQKENAEKELDKQRKFAEQ-IAQQKLSAEQECIRLKAdfe 1650
Cdd:pfam10174  562 LLEQEVARYK----EESGKAQAEVERLLGILREVEnEKNDKDKKIAELESLTLRQMKEQnKKVANIKHGQQEMKKKG--- 634

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1651 haeqqRGLLDNELQRLKNEV-NSTEKQRKQLEDELNKVRSEMDSlLQMKIN------AEKASMVNT---EKSKQLleSEA 1720
Cdd:pfam10174  635 -----AQLLEEARRREDNLAdNSQQLQLEELMGALEKTRQELDA-TKARLSstqqslAEKDGHLTNlraERRKQL--EEI 706

                          490
                   ....*....|.
gi 1389908296 1721 LKMKQLADEAA 1731
Cdd:pfam10174  707 LEMKQEALLAA 717
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2236-2509 1.10e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 1.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2236 AIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKetegFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQT 2315
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2316 KAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVqkletqrLQSTREADDLKSAIAdleeerkklkkeaeelqrkSKEMANA 2395
Cdd:COG4942     94 ELRAELEAQKEELAELLRALYRLGRQPPLALL-------LSPEDFLDAVRRLQY-------------------LKYLAPA 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2396 QQEQIEQQKAELQQsfLTEKglllkrekevegekkrfEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQ 2475
Cdd:COG4942    148 RREQAEELRADLAE--LAAL-----------------RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKEL 208

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1389908296 2476 KEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKK 2509
Cdd:COG4942    209 AELAAELAELQQEAEELEALIARLEAEAAAAAER 242
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1926-2304 1.19e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 61.68  E-value: 1.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1926 EAARQCKAAQEEVERLKK-KAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENA 2004
Cdd:pfam17380  286 ERQQQEKFEKMEQERLRQeKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERI 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2005 KKLAQEAEKAKEKAEKEAALLRQKAEEAEKQkkaaENEAAKQAKAQnDTEKQRKEaeeeaarraaaeaaalkqkQQADAE 2084
Cdd:pfam17380  366 RQEEIAMEISRMRELERLQMERQQKNERVRQ----ELEAARKVKIL-EEERQRKI-------------------QQQKVE 421

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2085 MSKHKKEAEQALQQKSQV---EKELTVVKLQLDETDKQkvlldQELQRVKgevndafkqksQVEVELARVRIQMEELVKL 2161
Cdd:pfam17380  422 MEQIRAEQEEARQREVRRleeERAREMERVRLEEQERQ-----QQVERLR-----------QQEEERKRKKLELEKEKRD 485

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2162 KLKIEEENRRLMQKDKdstqkllaeEAEKMKSLAEEAGRLSVEAEETARQRQIAESnlaEQRALAEKiLKEKMQAIQeat 2241
Cdd:pfam17380  486 RKRAEEQRRKILEKEL---------EERKQAMIEEERKRKLLEKEMEERQKAIYEE---ERRREAEE-ERRKQQEME--- 549

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2242 klkaEAEKLQKQKDQAQETAKRLQEdkqqiqqrLDKETEGFQKSLEAERKRQ-LEASAEAEKLK 2304
Cdd:pfam17380  550 ----ERRRIQEQMRKATEERSRLEA--------MEREREMMRQIVESEKARAeYEATTPITTIK 601
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1592-2057 1.62e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 1.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1592 QKLEAERDA--KKRGKAEEAALKQKENAEKELDKQRKFAEQIAQqklsAEQECIRLKADFEHAEQQRGLLDNELQRLKNE 1669
Cdd:COG4717     49 ERLEKEADElfKPQGRKPELNLKELKELEEELKEAEEKEEEYAE----LQEELEELEEELEELEAELEELREELEKLEKL 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1670 VN--STEKQRKQLEDELNKVRSEMDSLLQmkinaekasmvntekskqllesealKMKQLADEAARMRSVAEEAKKQRQIA 1747
Cdd:COG4717    125 LQllPLYQELEALEAELAELPERLEELEE-------------------------RLEELRELEEELEELEAELAELQEEL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1748 EEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEayqRKLLEDQAAQHKQDIEEKITQLQT 1827
Cdd:COG4717    180 EELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQL---ENELEAAALEERLKEARLLLLIAA 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1828 SSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIAdetQKSKLKAEEEAEKLKKLAAEEE 1907
Cdd:COG4717    257 ALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALP---ALEELEEEELEELLAALGLPPD 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1908 RRRKEAEEKVKRITAAEEEAARQCKAAQE-EVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSK 1986
Cdd:COG4717    334 LSPEELLELLDRIEELQELLREAEELEEElQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEE 413

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1987 NKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQR 2057
Cdd:COG4717    414 LLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAE 484
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2124-2334 1.76e-08

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 60.23  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2124 DQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRLmQKDKDSTQKLLAEEAEKMKSLAEEAGRLSV 2203
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEAL-QAEIDKLQAEIAEAEAEIEERREELGERAR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2204 EAEETARQRQIAE--------SNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRL 2275
Cdd:COG3883     94 ALYRSGGSVSYLDvllgsesfSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2276 DKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQ 2334
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1456-1638 1.80e-08

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 60.27  E-value: 1.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1456 KQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIrvveevaQKSAATQLQTKAmsfseqttklEESLKKEQGNVLKLQE 1535
Cdd:COG2268    180 EDENNYLDALGRRKIAEIIRDARIAEAEAERETEI-------AIAQANREAEEA----------ELEQEREIETARIAEA 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1536 EADKLKKQ---QKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALK 1612
Cdd:COG2268    243 EAELAKKKaeeRREAETARAEAEAAYEIAEANAEREVQRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAE 322

                          170       180
                   ....*....|....*....|....*.
gi 1389908296 1613 QKENAEKELDKQRKFAEQIAQQKLSA 1638
Cdd:COG2268    323 AEAEAEAEAIRAKGLAEAEGKRALAE 348
CH_ACTN3_rpt2 cd21289
second calponin homology (CH) domain found in alpha-actinin-3; Alpha-actinin-3 (ACTN3), also ...
 111-168 2.01e-08

second calponin homology (CH) domain found in alpha-actinin-3; Alpha-actinin-3 (ACTN3), also called alpha-actinin skeletal muscle isoform 3, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN3 is a bundling protein. It is critical in anchoring the myofibrillar actin filaments and plays a key role in muscle contraction. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409138  Cd Length: 124  Bit Score: 55.50  E-value: 2.01e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21289     53 PDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDiVNTPKPDEKAIMTYVSCFY 111
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1494-2283 2.61e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 60.62  E-value: 2.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1494 EEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQ-----------EEADKLKKQQKEANTAREEAEQELEIWR 1562
Cdd:pfam12128  221 QQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNTLESAELRLShlhfgyksdetLIASRQEERQETSAELNQLLRTLDDQWK 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1563 QKANEaLRLRLQAEEEA-QKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQiAQQKLSAEQE 1641
Cdd:pfam12128  301 EKRDE-LNGELSAADAAvAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTG-KHQDVTAKYN 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1642 CIRLKADFEHAeqqRGLLDNElQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINaekasmvNTEKSKQLLESEAL 1721
Cdd:pfam12128  379 RRRSKIKEQNN---RDIAGIK-DKLAKIREARDRQLAVAEDDLQALESELREQLEAGKL-------EFNEEEYRLKSRLG 447

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1722 KMKQLADEAarmrSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERL--KRQAEE 1799
Cdd:pfam12128  448 ELKLRLNQA----TATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLeeRQSALD 523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1800 EAYQR---------KLLEDQAAQHKQDIEEKITQ---LQTSSDSELGRQKNIVEETLKQKKVVEEEIHIikinfhkasKE 1867
Cdd:pfam12128  524 ELELQlfpqagtllHFLRKEAPDWEQSIGKVISPellHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDV---------PE 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1868 KADLESELKKLKGIADETqkskLKAEEEaeklkklaaeeerrrkeaeekvkRITAAEEEAArqckAAQEEVERLKKKAED 1947
Cdd:pfam12128  595 WAASEEELRERLDKAEEA----LQSARE-----------------------KQAAAEEQLV----QANGELEKASREETF 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1948 ANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLrdefeNAKKLAQEAEKAKEKAEKEAALLRQ 2027
Cdd:pfam12128  644 ARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQ-----LDKKHQAWLEEQKEQKREARTEKQA 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2028 KAEEAEKQKKAAEnEAAKQAKAQndTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELT 2107
Cdd:pfam12128  719 YWQVVEGALDAQL-ALLKAAIAA--RRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVL 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2108 VVKLQLDETdkqkvlLDQELQRVKGEVNDAFKQKSQVEVELARvriqMEELVKLKLKIEEENRrlmqKDKDSTQKLLAEE 2187
Cdd:pfam12128  796 RYFDWYQET------WLQRRPRLATQLSNIERAISELQQQLAR----LIADTKLRRAKLEMER----KASEKQQVRLSEN 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2188 AEKMKSLAEEAGRLSVEAEETARQRQIAESNlaeqRALAEkiLKEKMQAIQEATKLKAEAEKLQKQKDQAQ---ETAKRL 2264
Cdd:pfam12128  862 LRGLRCEMSKLATLKEDANSEQAQGSIGERL----AQLED--LKLKRDYLSESVKKYVEHFKNVIADHSGSglaETWESL 935

                          810       820
                   ....*....|....*....|..
gi 1389908296 2265 QEDKQQI---QQRLDKETEGFQ 2283
Cdd:pfam12128  936 REEDHYQndkGIRLLDYRKLVP 957
CH_CTX_rpt2 cd21226
second calponin homology (CH) domain found in cortexillin; Cortexillins are actin-bundling ...
 110-171 2.62e-08

second calponin homology (CH) domain found in cortexillin; Cortexillins are actin-bundling proteins that play a critical role in regulating cell morphology and actin cytoskeleton reorganization. They play a major role in cytokinesis and contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409075  Cd Length: 103  Bit Score: 54.39  E-value: 2.62e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  110 VPALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSLYDVM 171
Cdd:cd21226     42 DPELFKQAAIEQMDAEARLNLAFDFAEKKLGIPKLLEAEDVMTGNPDERSIVLYTSLFYHAF 103
CH_ACTN1_rpt2 cd21287
second calponin homology (CH) domain found in alpha-actinin-1; Alpha-actinin-1 (ACTN1), also ...
 111-168 2.79e-08

second calponin homology (CH) domain found in alpha-actinin-1; Alpha-actinin-1 (ACTN1), also called alpha-actinin cytoskeletal isoform, or non-muscle alpha-actinin-1, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN1 is a bundling protein. Its mutations cause congenital macrothrombocytopenia. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409136  Cd Length: 124  Bit Score: 55.09  E-value: 2.79e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21287     53 PELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDiVGTARPDEKAIMTYVSSFY 111
PRK12704 PRK12704
phosphodiesterase; Provisional
 1601-1802 2.86e-08

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 59.79  E-value: 2.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1601 KKRGKAEEAALKQKENAEKEldkqrkfAEQIAQQKLS-AEQECIRLKADFEhaeqqrglldNELQRLKNEVNSTEKQRKQ 1679
Cdd:PRK12704    31 AKIKEAEEEAKRILEEAKKE-------AEAIKKEALLeAKEEIHKLRNEFE----------KELRERRNELQKLEKRLLQ 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1680 LEDELNKvrsEMDSLlqmkinaekasmvntEKSKQLLESEALKMKQLADEAARMRSVAEEA-KKQRQIAEEEAARQRSEA 1758
Cdd:PRK12704    94 KEENLDR---KLELL---------------EKREEELEKKEKELEQKQQELEKKEEELEELiEEQLQELERISGLTAEEA 155

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1389908296 1759 EKILKEKLaaineatRLKTEAEMALKAKEAENErLKRQAEEEAY 1802
Cdd:PRK12704   156 KEILLEKV-------EEEARHEAAVLIKEIEEE-AKEEADKKAK 191
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2080-2321 3.32e-08

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 59.07  E-value: 3.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2080 QADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELV 2159
Cdd:COG3883     13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2160 klklkieeenrRLMQKDKDSTQKLLA-EEAEkmkSLAEEAGRLSVEAEETARQRQIAESnLAEQRALAEKILKEKMQAIQ 2238
Cdd:COG3883     93 -----------RALYRSGGSVSYLDVlLGSE---SFSDFLDRLSALSKIADADADLLEE-LKADKAELEAKKAELEAKLA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2239 EATKLKAEAEK----LQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQ 2314
Cdd:COG3883    158 ELEALKAELEAakaeLEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237


                   ....*..
gi 1389908296 2315 TKAEDEA 2321
Cdd:COG3883    238 AAAAAAA 244
PRK12704 PRK12704
phosphodiesterase; Provisional
 1394-1602 3.33e-08

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 59.79  E-value: 3.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1394 HKAKSEAELQELRdraAEAEKLRKAAQDEAERLRKQVAEETQrkknaEDELKRKSDAEKEAaKQKQRALDDLqkykmqae 1473
Cdd:PRK12704    25 RKKIAEAKIKEAE---EEAKRILEEAKKEAEAIKKEALLEAK-----EEIHKLRNEFEKEL-RERRNELQKL-------- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 eaERRMKQAEEekirqirvveevaqksaatQLQTKamsfSEQTTKLEESLKKEQGNVLKLQEEadkLKKQQKEANTAREE 1553
Cdd:PRK12704    88 --EKRLLQKEE-------------------NLDRK----LELLEKREEELEKKEKELEQKQQE---LEKKEEELEELIEE 139

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1554 AEQELE----IWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKK 1602
Cdd:PRK12704   140 QLQELErisgLTAEEAKEILLEKVEEEARHEAAVLIKEIEEEAKEEADKKAKE 192
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 1318-1877 3.49e-08

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 59.66  E-value: 3.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1318 LELKmKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQ-EIKSKNQQLEDAlvSRRKIEEEIHIIRIQLEKTTAHKA 1396
Cdd:pfam05701   42 LELE-KVQEEIPEYKKQSEAAEAAKAQVLEELESTKRLIEElKLNLERAQTEEA--QAKQDSELAKLRVEEMEQGIADEA 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1397 K--SEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEE 1474
Cdd:pfam05701  119 SvaAKAQLEVAKARHAAAVAELKSVKEELESLRKEYASLVSERDIAIKRAEEAVSASKEIEKTVEELTIELIATKESLES 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1475 AERRMKQAEEEKIRqirvveevaqksaatqlqtKAMSFSEQTTKLEESLKkeqgnvlKLQEEADKLKKQQkeanTAREEA 1554
Cdd:pfam05701  199 AHAAHLEAEEHRIG-------------------AALAREQDKLNWEKELK-------QAEEELQRLNQQL----LSAKDL 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1555 EQELEiwrqkANEALRLRLQAEEEAQKKSHAQEEAEKQKLEaerdaKKRGKAEEAALKQkenAEKELDKQRKFAEqiaqq 1634
Cdd:pfam05701  249 KSKLE-----TASALLLDLKAELAAYMESKLKEEADGEGNE-----KKTSTSIQAALAS---AKKELEEVKANIE----- 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1635 KLSAEQECIRLKAdfehaeqqrGLLDNELQRLKNEVNSTeKQRK--------QLEDELNKVRSEMdSLLQMKINAEKASM 1706
Cdd:pfam05701  311 KAKDEVNCLRVAA---------ASLRSELEKEKAELASL-RQREgmasiavsSLEAELNRTKSEI-ALVQAKEKEAREKM 379

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1707 VNTEKSKQLLESEALKMKQLAdEAARmrsvaEEAKKQRQIAEE-EAARQRSEA--EKILKEKLAAiNEATRLKTEAEMAL 1783
Cdd:pfam05701  380 VELPKQLQQAAQEAEEAKSLA-QAAR-----EELRKAKEEAEQaKAAASTVESrlEAVLKEIEAA-KASEKLALAAIKAL 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1784 KAKEAENE----------------------RLKRQAEEEAYQRklledqaaqhkqdIEEKITQLQTSSDSELgRQKNIVE 1841
Cdd:pfam05701  453 QESESSAEstnqedsprgvtlsleeyyelsKRAHEAEELANKR-------------VAEAVSQIEEAKESEL-RSLEKLE 518

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1389908296 1842 ETLKQKKVVEEEIHIIKINFHKASKEKADLESELKK 1877
Cdd:pfam05701  519 EVNREMEERKEALKIALEKAEKAKEGKLAAEQELRK 554
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1629-2355 3.90e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.74  E-value: 3.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1629 EQIAQQKLSAEQECIRlKADFEHAEQQRGL---LDNELQRLKNEVNSTEKQRKQLEDELNKVRSemdsLLQMKINAEKAS 1705
Cdd:pfam05483   51 EQVANSGDCHYQEGLK-DSDFENSEGLSRLyskLYKEAEKIKKWKVSIEAELKQKENKLQENRK----IIEAQRKAIQEL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1706 MVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEmALKA 1785
Cdd:pfam05483  126 QFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFE-ELRV 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1786 kEAENERLKR--QAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNI---VEETLKQKKVVEEEIHIIKIN 1860
Cdd:pfam05483  205 -QAENARLEMhfKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLtflLEESRDKANQLEEKTKLQDEN 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1861 FHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVER 1940
Cdd:pfam05483  284 LKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEE 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1941 LKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEK 2020
Cdd:pfam05483  364 LLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIF 443

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2021 EAALLRQKAEEAEKQ---KKAAENEAAKQA---KAQNDTEKQRKEAEEEAARRAAAEAAALKQ----------KQQADae 2084
Cdd:pfam05483  444 LLQAREKEIHDLEIQltaIKTSEEHYLKEVedlKTELEKEKLKNIELTAHCDKLLLENKELTQeasdmtlelkKHQED-- 521

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2085 MSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQkvlLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVK---- 2160
Cdd:pfam05483  522 IINCKKQEERMLKQIENLEEKEMNLRDELESVREE---FIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENkcnn 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2161 LKLKIEEENRRL--MQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEeTARQRQIAESNLAEQRALAEKILKEKM-QAI 2237
Cdd:pfam05483  599 LKKQIENKNKNIeeLHQENKALKKKGSAENKQLNAYEIKVNKLELELA-SAKQKFEEIIDNYQKEIEDKKISEEKLlEEV 677

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2238 QEATKLKAEAEKLQKQKDqaqetaKRLQEDKQQIQQRLDKETEGFQKSLEaerkrqlEASAEAEKLKLRVKELSLAQTKA 2317
Cdd:pfam05483  678 EKAKAIADEAVKLQKEID------KRCQHKIAEMVALMEKHKHQYDKIIE-------ERDSELGLYKNKEQEQSSAKAAL 744

                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 1389908296 2318 EDEAKKFKKQADEVKAQLQrtekhtteivVQKLETQRL 2355
Cdd:pfam05483  745 EIELSNIKAELLSLKKQLE----------IEKEEKEKL 772
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1983-2531 3.95e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.08  E-value: 3.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1983 VLSKNKEDVLAQ-EKLRDEFENAKK-LAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEA 2060
Cdd:TIGR02169  227 ELLKEKEALERQkEAIERQLASLEEeLEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASL 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2061 EEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQ 2140
Cdd:TIGR02169  307 ERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDE 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2141 KSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKL------LAEEAEKMKSLAEEAGRLSVEAEETARQRQI 2214
Cdd:TIGR02169  387 LKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIagieakINELEEEKEDKALEIKKQEWKLEQLAADLSK 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2215 AESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQ---QRLDKETEGFQKSLEAERK 2291
Cdd:TIGR02169  467 YEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHgtvAQLGSVGERYATAIEVAAG 546

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2292 RQLEA--------SAEAEKLKLRVK--------------ELSLAQTKAEDEAKKF--------KKQADEVKAQLQRTekh 2341
Cdd:TIGR02169  547 NRLNNvvveddavAKEAIELLKRRKagratflplnkmrdERRDLSILSEDGVIGFavdlvefdPKYEPAFKYVFGDT--- 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2342 tteIVVQKLETQRLQS-------------------TREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQ--I 2400
Cdd:TIGR02169  624 ---LVVEDIEAARRLMgkyrmvtlegelfeksgamTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELrrI 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2401 EQQKAELQQSFLTEKGLLLKREKEVE---GEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVR---- 2473
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEqleQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKleea 780

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2474 ----KQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVsQTKESQ 2531
Cdd:TIGR02169  781 lndlEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI-QELQEQ 841
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1416-1634 4.21e-08

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 59.19  E-value: 4.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1416 RKAAQDEAERLRKQVAE----ETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKmqAEEAERRMKQAEEEKIRQir 1491
Cdd:pfam15709  328 REQEKASRDRLRAERAEmrrlEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRR--FEEIRLRKQRLEEERQRQ-- 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1492 vveEVAQKSAATQLQTKamsfSEQTTKLEESLKKeqgnvlKLQEEadKLKKQQKEANTAREEAEQELEIWRQKANEALRL 1571
Cdd:pfam15709  404 ---EEEERKQRLQLQAA----QERARQQQEEFRR------KLQEL--QRKKQQEEAERAEAEKQRQKELEMQLAEEQKRL 468

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1572 RLQAEEEaqkkshaQEEAEKQKLEAErdAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQ 1634
Cdd:pfam15709  469 MEMAEEE-------RLEYQRQKQEAE--EKARLEAEERRQKEEEAARLALEEAMKQAQEQARQ 522
PLEC smart00250
Plectin repeat;
3959-3995 4.49e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 51.71  E-value: 4.49e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3959 IRLLEAQIATGGIIDPQESHRLPVETAYERGLFDEEM 3995
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2148-2518 4.54e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.40  E-value: 4.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2148 LARVRIQMEELVKLKLKIEEENRRLMQKdkdsTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQI-----AESNLAEQ 2222
Cdd:COG4717     48 LERLEKEADELFKPQGRKPELNLKELKE----LEEELKEAEEKEEEYAELQEELEELEEELEELEAEleelrEELEKLEK 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2223 RALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEK 2302
Cdd:COG4717    124 LLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2303 LKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKhtteivVQKLETQR------------LQSTREADDLKSAIAD 2370
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAAL------EERLKEARlllliaaallalLGLGGSLLSLILTIAG 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2371 LEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKA------ELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAK 2444
Cdd:COG4717    278 VLFLVLGLLALLFLLLAREKASLGKEAEELQALPAleeleeEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAE 357

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2445 ALkdEQERQRKLMEEERKKL----QAIMDEAVRKQKEAEEEMKNKQREMDVLdkkrleqEKQLAEENKKLREQLQTFE 2518
Cdd:COG4717    358 EL--EEELQLEELEQEIAALlaeaGVEDEEELRAALEQAEEYQELKEELEEL-------EEQLEELLGELEELLEALD 426
CH_ACTN4_rpt2 cd21290
second calponin homology (CH) domain found in alpha-actinin-4; Alpha-actinin-4 (ACTN4), also ...
 111-168 4.92e-08

second calponin homology (CH) domain found in alpha-actinin-4; Alpha-actinin-4 (ACTN4), also called non-muscle alpha-actinin 4, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. It is associated with cell motility and cancer invasion. ACTN4 is probably involved in vesicular trafficking via its association with the CART complex, which is necessary for efficient transferrin receptor recycling but not for epidermal growth factor receptor (EGFR) degradation. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409139  Cd Length: 125  Bit Score: 54.32  E-value: 4.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21290     56 PELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDiVNTARPDEKAIMTYVSSFY 114
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1388-1893 4.95e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 59.85  E-value: 4.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1388 LEKTTAHKAKSEAELQElrdraaeaEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQK 1467
Cdd:pfam12128  258 LRLSHLHFGYKSDETLI--------ASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALED 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1468 YKMQAEEAERRMKQAEEEKIRQIRvvEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQgNVLKLQEEADKLKKQQKEA 1547
Cdd:pfam12128  330 QHGAFLDADIETAAADQEQLPSWQ--SELENLEERLKALTGKHQDVTAKYNRRRSKIKEQ-NNRDIAGIKDKLAKIREAR 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1548 NTAREEAEQELEiwrqkaneALRLRLQAEEEAQKKShAQEEAEKQKLEAErDAKKR---GKAEEAALKQKENAEKELDKQ 1624
Cdd:pfam12128  407 DRQLAVAEDDLQ--------ALESELREQLEAGKLE-FNEEEYRLKSRLG-ELKLRlnqATATPELLLQLENFDERIERA 476

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1625 RKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQ------------RKQL---EDELNKV-- 1687
Cdd:pfam12128  477 REEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhflRKEApdwEQSIGKVis 556

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1688 -----RSEMD------------SLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAarmRSVAEEAKKQ------- 1743
Cdd:pfam12128  557 pellhRTDLDpevwdgsvggelNLYGVKLDLKRIDVPEWAASEEELRERLDKAEEALQSA---REKQAAAEEQlvqange 633

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1744 --RQIAEEEAARQrseAEKILKEKLAaineatRLKTEAEMALKAKEAENERLKRQAEEE----AYQRKLLEDqaaQHKQD 1817
Cdd:pfam12128  634 leKASREETFART---ALKNARLDLR------RLFDEKQSEKDKKNKALAERKDSANERlnslEAQLKQLDK---KHQAW 701

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1818 IEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINfHKA--SKEKADLESELKKLkGIaDETQKSKLKAE 1893
Cdd:pfam12128  702 LEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSG-AKAelKALETWYKRDLASL-GV-DPDVIAKLKRE 776
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1393-1827 4.97e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.54  E-value: 4.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1393 AHKAKSEAELQELRDRAA--EAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELK----RKSDAEKEAAKQKQRALDDLQ 1466
Cdd:COG4913    265 AAARERLAELEYLRAALRlwFAQRRLELLEAELEELRAELARLEAELERLEARLDalreELDELEAQIRGNGGDRLEQLE 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAA--TQLQTKAMSFSEQTTKLEEslkkeqgnvlKLQEEADKLKKQQ 1544
Cdd:COG4913    345 REIERLERELEERERRRARLEALLAALGLPLPASAEefAALRAEAAALLEALEEELE----------ALEEALAEAEAAL 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1545 KEANTAREEAEQELEIWRQKAN----EALRLRLQAEEEAQKKS------------HAQEE-----AEK------------ 1591
Cdd:COG4913    415 RDLRRELRELEAEIASLERRKSnipaRLLALRDALAEALGLDEaelpfvgelievRPEEErwrgaIERvlggfaltllvp 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1592 ----------------------QKLEAERDAKKRGKAEEAALKQK----EN-----AEKELDKQRKFA-----EQIAQQK 1635
Cdd:COG4913    495 pehyaaalrwvnrlhlrgrlvyERVRTGLPDPERPRLDPDSLAGKldfkPHpfrawLEAELGRRFDYVcvdspEELRRHP 574

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1636 LSAEQEC-IRLKAD-FEH---------------AEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMK 1698
Cdd:COG4913    575 RAITRAGqVKGNGTrHEKddrrrirsryvlgfdNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLA 654

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1699 ------INAEKASMVNTEKSKQL--LESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEaekilkeklaaIN 1770
Cdd:COG4913    655 eyswdeIDVASAEREIAELEAELerLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKE-----------LE 723

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1771 EATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQT 1827
Cdd:COG4913    724 QAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRA 780
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1286-1696 5.47e-08

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 59.43  E-value: 5.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1286 RRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMkeeASKRQDVaadaeKQKQniqQELQHLKSLSDQEIKSKNQ 1365
Cdd:PRK10246   425 RQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAAL---NEMRQRY-----KEKT---QQLADVKTICEQEARIKDL 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1366 QLEDALVSRRKIEEeihiiriqLEKTTAHKAKSEAELQELRD---RAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAED 1442
Cdd:PRK10246   494 EAQRAQLQAGQPCP--------LCGSTSHPAVEAYQALEPGVnqsRLDALEKEVKKLGEEGAALRGQLDALTKQLQRDES 565

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1443 ELKRKSDAEKEAAKQKQRAL----------DDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAAT-QLQTKAMS 1511
Cdd:PRK10246   566 EAQSLRQEEQALTQQWQAVCaslnitlqpqDDIQPWLDAQEEHERQLRLLSQRHELQGQIAAHNQQIIQYQqQIEQRQQQ 645

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1512 FSEQTTKLEESLKKEQGNVLKL---QEEADKLKKQQKEANTAREEAEQ---------------------ELEIWRQKANE 1567
Cdd:PRK10246   646 LLTALAGYALTLPQEDEEASWLatrQQEAQSWQQRQNELTALQNRIQQltplletlpqsddlphseetvALDNWRQVHEQ 725

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1568 ALRL-------RLQAEEEAQKKSHAQ---EEAEKQKLEAERDAKKRGKAEEAAL----KQKENAEKELDKQRKFAEQiAQ 1633
Cdd:PRK10246   726 CLSLhsqlqtlQQQDVLEAQRLQKAQaqfDTALQASVFDDQQAFLAALLDEETLtqleQLKQNLENQRQQAQTLVTQ-TA 804

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1634 QKLSAEQ----ECIRLKADFEHAEQQRGLLDnelQRLKNEVNSTEKQRKQL-EDELNkvRSEMDSLLQ 1696
Cdd:PRK10246   805 QALAQHQqhrpDGLDLTVTVEQIQQELAQLA---QQLRENTTRQGEIRQQLkQDADN--RQQQQALMQ 867
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1286-1554 5.81e-08

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 58.73  E-value: 5.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1286 RRKMAEIQAELDKQKQMAEAHA-KSVAKAEQEALELKMKMKEEASKRQDVAADAEKQ--KQNIQQELQHLKSLSDQEIKS 1362
Cdd:COG2268    191 RRKIAEIIRDARIAEAEAERETeIAIAQANREAEEAELEQEREIETARIAEAEAELAkkKAEERREAETARAEAEAAYEI 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1363 KNQQLEDALvsrrKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAErlrkqvAEETQRKKNAED 1442
Cdd:COG2268    271 AEANAEREV----QRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAEAEAEAE------AEAIRAKGLAEA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1443 ELKRksdAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAeeEKIRQIRVVEEVAQKSAATQLQTKAMsfseqtTKLEES 1522
Cdd:COG2268    341 EGKR---ALAEAWNKLGDAAILLMLIEKLPEIAEAAAKPL--EKIDKITIIDGGNGGNGAGSAVAEAL------APLLES 409

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1389908296 1523 LKKEQGnvLKLQEEADKLKKQQKEANTAREEA 1554
Cdd:COG2268    410 LLEETG--LDLPGLLKGLTGAGAAAPAGEPAE 439
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1287-1634 5.86e-08

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 58.73  E-value: 5.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1287 RKMAEIQAELdkqKQMAEAHAKSVAKaeqealelKMKMKEEASKRQDVAadaEKQKQNIQQELQ----HLKSLSDQEIKS 1362
Cdd:COG2268    116 RDPEEIEELA---EEKLEGALRAVAA--------QMTVEELNEDREKFA---EKVQEVAGTDLAknglELESVAITDLED 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1363 KNQQLeDALvSRRKIEEEihiiriqleKTTAHKAKSEAElQELRDRAAEAEKLRKAAQDEAERlrkqvaeetqrkknaed 1442
Cdd:COG2268    182 ENNYL-DAL-GRRKIAEI---------IRDARIAEAEAE-RETEIAIAQANREAEEAELEQER----------------- 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1443 ELKRKSDAEKEAAKQKQRAlddlqkykmqaeEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAmsfseqttklees 1522
Cdd:COG2268    233 EIETARIAEAEAELAKKKA------------EERREAETARAEAEAAYEIAEANAEREVQRQLEIAE------------- 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1523 lkkeqgnvlklQEEADKLKKQQKEantaREEAEQELEIwrQKANEALRLRLQAEEEAqkkshaqeEAEKQKLEAERDAKK 1602
Cdd:COG2268    288 -----------REREIELQEKEAE----REEAELEADV--RKPAEAEKQAAEAEAEA--------EAEAIRAKGLAEAEG 342

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1389908296 1603 RGKAEEAALKQKENAEKE--LDKQRKFAEQIAQQ 1634
Cdd:COG2268    343 KRALAEAWNKLGDAAILLmlIEKLPEIAEAAAKP 376
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1274-1515 5.98e-08

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 58.28  E-value: 5.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1274 DEKASEKLKEEERRKMAEIQAELDKQKQMAEahaksvakaeQEalelkmKMKEEASKRQdvaADAEKQKQNIQQElqhlk 1353
Cdd:PRK09510    69 QQQKSAKRAEEQRKKKEQQQAEELQQKQAAE----------QE------RLKQLEKERL---AAQEQKKQAEEAA----- 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1354 slsdQEIKSKNQQLEDAlvsrrkieeeihiiriqlEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEE 1433
Cdd:PRK09510   125 ----KQAALKQKQAEEA------------------AAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAE 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1434 TQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRqirvveevAQKSAATQLQTKAMSFS 1513
Cdd:PRK09510   183 AKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAA--------AEKAAAAKAAEKAAAAK 254


                   ..
gi 1389908296 1514 EQ 1515
Cdd:PRK09510   255 AA 256
Caldesmon pfam02029
Caldesmon;
1449-1766 8.38e-08

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 58.34  E-value: 8.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1449 DAEKEAAKQKQRalddlqkykmQAEEAERRMKQaEEEKIRQIRVVEEVAQKSAATQLQTKAMS----------FSEQTTK 1518
Cdd:pfam02029    2 EDEEEAARERRR----------RAREERRRQKE-EEEPSGQVTESVEPNEHNSYEEDSELKPSgqggldeeeaFLDRTAK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1519 LEESLKKEQGNVLKLQEEADKLKKQQKE--ANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKShaQEEAEKQKLEA 1596
Cdd:pfam02029   71 REERRQKRLQEALERQKEFDPTIADEKEsvAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIRE--KEYQENKWSTE 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1597 ERDAKKRGKAEEaalkQKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRglldnelqRLKNEVNSTEKQ 1676
Cdd:pfam02029  149 VRQAEEEGEEEE----DKSEEAEEVPTENFAKEEVKDEKIKKEKK---VKYESKVFLDQK--------RGHPEVKSQNGE 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1677 RKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEK-------SKQLLESEAL-KMKQLADEAA-----------RMRSVA 1737
Cdd:pfam02029  214 EEVTKLKVTTKRRQGGLSQSQEREEEAEVFLEAEQkleelrrRRQEKESEEFeKLRQKQQEAEleleelkkkreERRKLL 293

                          330       340
                   ....*....|....*....|....*....
gi 1389908296 1738 EEAKKQRQIAEEEAARQRSEAEKILKEKL 1766
Cdd:pfam02029  294 EEEEQRRKQEEAERKLREEEEKRRMKEEI 322
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1517-1878 8.39e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 58.37  E-value: 8.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1517 TKLEESLKkEQGNVLKLQEEADKLKKQQKEAntaREEAEQELEIWRQkaneALRLRLQ-AEEEAQKKSHAQEEAEKQKLE 1595
Cdd:pfam07888   34 NRLEECLQ-ERAELLQAQEAANRQREKEKER---YKRDREQWERQRR----ELESRVAeLKEELRQSREKHEELEEKYKE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1596 AERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEK 1675
Cdd:pfam07888  106 LSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1676 QRKQLEDELNKVRSEMD----SLLQMKINAEKASMVNTEKSKQLLESEALKmkqladeaARMRSVAEEAKKQRQIAE--- 1748
Cdd:pfam07888  186 ELRSLSKEFQELRNSLAqrdtQVLQLQDTITTLTQKLTTAHRKEAENEALL--------EELRSLQERLNASERKVEglg 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1749 ---EEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEA----ENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEK 1821
Cdd:pfam07888  258 eelSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRArwaqERETLQQSAEADKDRIEKLSAELQRLEERLQEE 337

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1822 ITQLQtSSDSELGRQKNIveeTLKQKKVVEEEIHIIKINFHKASKEKADLESELKKL 1878
Cdd:pfam07888  338 RMERE-KLEVELGREKDC---NRVQLSESRRELQELKASLRVAQKEKEQLQAEKQEL 390
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1454-1626 8.63e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 56.47  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1454 AAKQKQRALDDLQKYKMQAEEAERRMKQAEEEkirqirvVEEVAQKSAAtqLQTKAMSFSEQTTKLEESLKKEQGNVLKL 1533
Cdd:COG1579      1 AMPEDLRALLDLQELDSELDRLEHRLKELPAE-------LAELEDELAA--LEARLEAAKTELEDLEKEIKRLELEIEEV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1534 QEEADKLKKQQKEANTARE--EAEQELEIW--RQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKrgKAEEA 1609
Cdd:COG1579     72 EARIKKYEEQLGNVRNNKEyeALQKEIESLkrRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKK--AELDE 149

                          170
                   ....*....|....*..
gi 1389908296 1610 ALKQKENAEKELDKQRK 1626
Cdd:COG1579    150 ELAELEAELEELEAERE 166
CH_MICAL_EHBP-like cd22198
calponin homology (CH) domain found in the MICAL and EHBP families; This group is composed of ...
 111-170 8.94e-08

calponin homology (CH) domain found in the MICAL and EHBP families; This group is composed of the molecule interacting with CasL protein (MICAL) and EH domain-binding protein (EHBP) families. MICAL is a large, multidomain, cytosolic protein with a single LIM domain, a calponin homology (CH) domain and a flavoprotein monooxygenase (MO) domain. In Drosophila, MICAL is expressed in axons, interacts with the neuronal A (PlexA) receptor and is required for Semaphorin 1a (Sema-1a)-PlexA-mediated repulsive axon guidance. The LIM and CH domains mediate interactions with the cytoskeleton, cytoskeletal adaptor proteins, and other signaling proteins. The flavoprotein MO is required for semaphorin-plexin repulsive axon guidance during axonal pathfinding in the Drosophila neuromuscular system. The EHBP family includes EHBP1 and EHBP1-like protein (EHBP1L1). EHBP1 is a regulator of endocytic recycling and may play a role in actin reorganization by linking clathrin-mediated endocytosis to the actin cytoskeleton. It may act as an effector of small GTPases, including RAB-10 (Rab10), and play a role in vesicle trafficking. EHBP proteins contain a single CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409188  Cd Length: 105  Bit Score: 53.06  E-value: 8.94e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLYDV 170
Cdd:cd22198     43 PDLIDFSSLDPENIAENNQLAFDVAEQELGIPPVMTGQEmASLAVPDKLSMVSYLSQFYEA 103
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1334-1593 9.47e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 9.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1334 VAADAEKQKQNIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAE 1413
Cdd:COG4942     14 AAAAQADAAAEAEAELEQLQ----QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1414 KLRKAAQDEAERLRKQVAEE--TQRKKNAEDELKRKSDAEkeAAKQKQRALDDLQKYkmqaeeAERRMKQAEEekirqir 1491
Cdd:COG4942     90 KEIAELRAELEAQKEELAELlrALYRLGRQPPLALLLSPE--DFLDAVRRLQYLKYL------APARREQAEE------- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1492 vveevaQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRL 1571
Cdd:COG4942    155 ------LRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228

                          250       260
                   ....*....|....*....|....
gi 1389908296 1572 --RLQAEEEAQKKSHAQEEAEKQK 1593
Cdd:COG4942    229 iaRLEAEAAAAAERTPAAGFAALK 252
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1466-1676 1.09e-07

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 57.51  E-value: 1.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1466 QKYKMQAEEAERRMKQAEEEKirqirvvEEVAQKSAATQLQTKAMsfsEQTTKLEESLKKEQGNVLKL----QEEADKLK 1541
Cdd:PRK09510    69 QQQKSAKRAEEQRKKKEQQQA-------EELQQKQAAEQERLKQL---EKERLAAQEQKKQAEEAAKQaalkQKQAEEAA 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1542 KQQKEANTAREEAEQE-LEIWRQKANEALRLRLQAEEEAQKKSHAQEEAE-KQKLEAERDAKKRGKAeEAALKQKENAEK 1619
Cdd:PRK09510   139 AKAAAAAKAKAEAEAKrAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEaEAAAKAAAEAKKKAEA-EAKKKAAAEAKK 217

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1620 ELDKQRKFAEQ--IAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQ 1676
Cdd:PRK09510   218 KAAAEAKAAAAkaAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTG 276
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1632-1831 1.20e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 1.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1632 AQQKLSAEQECIR-LKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLlQMKINAEKASMVNTE 1710
Cdd:COG4942     25 AEAELEQLQQEIAeLEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAEL-EKEIAELRAELEAQK 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1711 KSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAEN 1790
Cdd:COG4942    104 EELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAEL 183

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1389908296 1791 ERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDS 1831
Cdd:COG4942    184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEE 224
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1606-1854 1.22e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.39  E-value: 1.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1606 AEEAALKQKENAEKeLDKQRKFAEQIAQQKLSAE-QECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDEL 1684
Cdd:COG4913    240 AHEALEDAREQIEL-LEPIRELAERYAAARERLAeLEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1685 NKVRSEMDSLLQmkinaekasmvntekskQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKE 1764
Cdd:COG4913    319 DALREELDELEA-----------------QIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEE 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1765 KLAAINEATRLKTEAemalkakeaenERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQtssdselGRQKNIVEETL 1844
Cdd:COG4913    382 FAALRAEAAALLEAL-----------EEELEALEEALAEAEAALRDLRRELRELEAEIASLE-------RRKSNIPARLL 443

                          250
                   ....*....|
gi 1389908296 1845 KQKKVVEEEI 1854
Cdd:COG4913    444 ALRDALAEAL 453
Caldesmon pfam02029
Caldesmon;
1314-1650 1.24e-07

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 57.96  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1314 EQEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLS------DQEIKSKNQQLEDalvSRRKIEEEIHIIRIQ 1387
Cdd:pfam02029   12 RRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGqggldeEEAFLDRTAKREE---RRQKRLQEALERQKE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1388 LEKTTAHKAKSEAElQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKnaEDELKRKSDAEKEAAKQKQralddlQK 1467
Cdd:pfam02029   89 FDPTIADEKESVAE-RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREK--EYQENKWSTEVRQAEEEGE------EE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1468 YKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEA 1547
Cdd:pfam02029  160 EDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1548 NTAREEAEQELEIWRQKANEAlrlrlqAEEEAQKKSHAQEEAEkqkLEAERDAKKRgkaeeaalKQKENAEKELDKQRKF 1627
Cdd:pfam02029  240 AEVFLEAEQKLEELRRRRQEK------ESEEFEKLRQKQQEAE---LELEELKKKR--------EERRKLLEEEEQRRKQ 302

                          330       340
                   ....*....|....*....|...
gi 1389908296 1628 AEqiAQQKLSAEQECIRLKADFE 1650
Cdd:pfam02029  303 EE--AERKLREEEEKRRMKEEIE 323
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1520-1679 1.31e-07

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 57.71  E-value: 1.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEeeAQKKSHAQEEAEKQKLEAERD 1599
Cdd:pfam05262  209 QEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAKNLPKPAD--TSSPKEDKQVAENQKREIEKA 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1600 AKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKlsaeqecirlkadfeHAEQQRGLLD--NELQRLKNEVNSTEKQR 1677
Cdd:pfam05262  287 QIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDK---------------ELEAQKKREPvaEDLQKTKPQVEAQPTSL 351


                   ..
gi 1389908296 1678 KQ 1679
Cdd:pfam05262  352 NE 353
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1275-1485 1.53e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 56.78  E-value: 1.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1275 EKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQdvAADAEKQKQNiqqelqhlks 1354
Cdd:TIGR02794   79 EAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKA--EAEAERKAKE---------- 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1355 lsdqeiKSKNQQLEDALVSrrkieeeihiiriqlEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDE----AERLRKQV 1430
Cdd:TIGR02794  147 ------EAAKQAEEEAKAK---------------AAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEakakAEAAKAKA 205

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 1431 AEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEE 1485
Cdd:TIGR02794  206 AAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSE 260
mukB PRK04863
chromosome partition protein MukB;
1520-1880 1.65e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 58.04  E-value: 1.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQGNVLKLQEEADklkkQQKEANTAREEAEQELEIWRQKANEALRL-----RLQAE-EEAQKKSHAQEEA--EK 1591
Cdd:PRK04863   299 RRQLAAEQYRLVEMARELA----ELNEAESDLEQDYQAASDHLNLVQTALRQqekieRYQADlEELEERLEEQNEVveEA 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1592 QKLEAERDAKKRgKAEEAAL---KQKENAEKELDKQRKFAEQI--AQQKLSAEQECIRLK-----------ADFEHAEQQ 1655
Cdd:PRK04863   375 DEQQEENEARAE-AAEEEVDelkSQLADYQQALDVQQTRAIQYqqAVQALERAKQLCGLPdltadnaedwlEEFQAKEQE 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1656 rglLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSllqmkINAEKASmvntEKSKQLLEsEALKMKQLADEAARMRS 1735
Cdd:PRK04863   454 ---ATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGE-----VSRSEAW----DVARELLR-RLREQRHLAEQLQQLRM 520

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1736 VAEEAKkQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALkakeaenERLKRQAEEEAYQRKLLEDQAAQHK 1815
Cdd:PRK04863   521 RLSELE-QRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARL-------ESLSESVSEARERRMALRQQLEQLQ 592

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1816 QDIEE---KITQLQTSSDSeLGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKG 1880
Cdd:PRK04863   593 ARIQRlaaRAPAWLAAQDA-LARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDE 659
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1308-1968 1.85e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.81  E-value: 1.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1308 KSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNIQQ---ELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHII 1384
Cdd:pfam05483   85 KEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQElqfENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETC 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1385 RIQLEKTTAHKAKSEAELQELRDRAAEAEK-------LRKAAQDEAERLRKQVAEETQRKKNAEDELKRK-SDAEKEAA- 1455
Cdd:pfam05483  165 ARSAEKTKKYEYEREETRQVYMDLNNNIEKmilafeeLRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEiNDKEKQVSl 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1456 -----KQKQRALDDLQkykMQAEEAERRMKQAEEEKIRQIRVVEEVAQKS--AATQLQTKAMSFSEQTTK---LEESLKK 1525
Cdd:pfam05483  245 lliqiTEKENKMKDLT---FLLEESRDKANQLEEKTKLQDENLKELIEKKdhLTKELEDIKMSLQRSMSTqkaLEEDLQI 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1526 EQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRL---RLQAEEEAQKKSHAQEEAEKQKLEAERDAKK 1602
Cdd:pfam05483  322 ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTeqqRLEKNEDQLKIITMELQKKSSELEEMTKFKN 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1603 RGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLkadFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLED 1682
Cdd:pfam05483  402 NKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFL---LQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKT 478

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1683 ELNK----------------------VRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMK--QLADEaarMRSVAE 1738
Cdd:pfam05483  479 ELEKeklknieltahcdklllenkelTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKemNLRDE---LESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1739 EAKKQRQ-------IAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKE---AENERLKRQAEEE-----AYQ 1803
Cdd:pfam05483  556 EFIQKGDevkckldKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEelhQENKALKKKGSAEnkqlnAYE 635

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1804 RKL--LEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGI 1881
Cdd:pfam05483  636 IKVnkLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 715

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1882 ADETQKSKlkaEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLkkkaedankqkekaEKEAEK 1961
Cdd:pfam05483  716 YDKIIEER---DSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKL--------------KMEAKE 778


                   ....*..
gi 1389908296 1962 QVVLAKE 1968
Cdd:pfam05483  779 NTAILKD 785
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1629-2287 1.90e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.93  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1629 EQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQ----RLKNEVNSTEKQRKQLEDELN-----------KVRSEMDS 1693
Cdd:pfam12128  247 QQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQetsaELNQLLRTLDDQWKEKRDELNgelsaadaavaKDRSELEA 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1694 LLQMKINAEKAsmvNTEKSKQLLESEALKMKQLADEAARM-------RSVAEEAKKQRQIAEEEAARQRSEaekiLKEKL 1766
Cdd:pfam12128  327 LEDQHGAFLDA---DIETAAADQEQLPSWQSELENLEERLkaltgkhQDVTAKYNRRRSKIKEQNNRDIAG----IKDKL 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1767 AAINEA-TRLKTEAEMALKAKEAE-NERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKItqlqtssdselgrqknIVEETL 1844
Cdd:pfam12128  400 AKIREArDRQLAVAEDDLQALESElREQLEAGKLEFNEEEYRLKSRLGELKLRLNQAT----------------ATPELL 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1845 KQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKklaaeeerrrkeaeekvkriTAAE 1924
Cdd:pfam12128  464 LQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQ--------------------SALD 523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1925 EEAARQCKAAQEEVERLKKKAEDANKQKEKaekeaekqvVLAKEAAQKC------TAAEQKAQDVLSKNKEDVLA----- 1993
Cdd:pfam12128  524 ELELQLFPQAGTLLHFLRKEAPDWEQSIGK---------VISPELLHRTdldpevWDGSVGGELNLYGVKLDLKRidvpe 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1994 ----QEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKqkkaaENEAAKQAKAQND------TEKQRKEAEEE 2063
Cdd:pfam12128  595 waasEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASR-----EETFARTALKNARldlrrlFDEKQSEKDKK 669

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2064 AARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQ-----LDETDKQKVLLDQELQRVKGEVNDAF 2138
Cdd:pfam12128  670 NKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAywqvvEGALDAQLALLKAAIAARRSGAKAEL 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2139 KQ-KSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDST-----------------QKLLAEEAEKMKSLAEEAGR 2200
Cdd:pfam12128  750 KAlETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQevlryfdwyqetwlqrrPRLATQLSNIERAISELQQQ 829

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2201 LSVEAEETARQRQIAESNLAEQRALAEKIlkekmqaIQEATKLKAEAEKLQKQK-----DQAQETAKRLQEDKQQIQQRL 2275
Cdd:pfam12128  830 LARLIADTKLRRAKLEMERKASEKQQVRL-------SENLRGLRCEMSKLATLKedansEQAQGSIGERLAQLEDLKLKR 902

                          730
                   ....*....|..
gi 1389908296 2276 DKETEGFQKSLE 2287
Cdd:pfam12128  903 DYLSESVKKYVE 914
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1509-1732 1.99e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1509 AMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIwRQKANEALRLRLQAEEEAQKKSHAQEE 1588
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAA-LARRIRALEQELAALEAELAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1589 AEKQKLEAERD--------AKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRGLLD 1660
Cdd:COG4942     94 ELRAELEAQKEelaellraLYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEE---LRADLAELAALRAELE 170

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 1661 NELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSlLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAAR 1732
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLAR-LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1388-1738 2.73e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 57.27  E-value: 2.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1388 LEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQrkknAEDELKRKsdaekeaAKQKQRALDDLQK 1467
Cdd:COG3096    356 LEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQ----ALDVQQTR-------AIQYQQAVQALEK 424

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1468 YKMQAEEAERRMKQAEeekirqirvvEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKlkkqQKEA 1547
Cdd:COG3096    425 ARALCGLPDLTPENAE----------DYLAAFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELVCKIAG----EVER 490

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1548 NTAREEAEQELEIWRQKANEALRLR-LQAE-EEAQKKSHAQEEAEKQkleAERDAKKRGKAEEAALkQKENAEKELDKQR 1625
Cdd:COG3096    491 SQAWQTARELLRRYRSQQALAQRLQqLRAQlAELEQRLRQQQNAERL---LEEFCQRIGQQLDAAE-ELEELLAELEAQL 566

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1626 kfaEQIAQQKLSAEQECIRLKADFEHAEQQRGLL----------DNELQRLKNEVNSTekqrkqLEDelnkvRSEMDSLL 1695
Cdd:COG3096    567 ---EELEEQAAEAVEQRSELRQQLEQLRARIKELaarapawlaaQDALERLREQSGEA------LAD-----SQEVTAAM 632

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 1696 QMKINAEKASMVNTEKS---KQLLESEALKMKQLA-DEAARMRSVAE 1738
Cdd:COG3096    633 QQLLEREREATVERDELaarKQALESQIERLSQPGgAEDPRLLALAE 679
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1279-1636 2.93e-07

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 56.08  E-value: 2.93e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1279 EKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEaskRQDVAADAEKQKQNIQQELQhlkslsdq 1358
Cdd:pfam13868   26 AQIAEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRY---RQELEEQIEEREQKRQEEYE-------- 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1359 eiksknQQLEDALVSRRKIEEEIHIIRIQLEKttahKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKK 1438
Cdd:pfam13868   95 ------EKLQEREQMDEIVERIQEEDQAEAEE----KLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEK 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1439 NAEDELKRKSDAEKEAAKQKQRAlddlqkyKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKamsfsEQTTK 1518
Cdd:pfam13868  165 AEREEEREAEREEIEEEKEREIA-------RLRAQQEKAQDEKAERDELRAKLYQEEQERKERQKEREEA-----EKKAR 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1519 LEESLKKEQgnvlkLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEAlrlRLQAEEEAQKKSHAQEEAEKQKLEAER 1598
Cdd:pfam13868  233 QRQELQQAR-----EEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIE---QEEAEKRRMKRLEHRRELEKQIEEREE 304

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1389908296 1599 dakKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKL 1636
Cdd:pfam13868  305 ---QRAAEREEELEEGERLREEEAERRERIEEERQKKL 339
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2178-2370 2.94e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 2.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2178 DSTQKLLAEEAEKMKSLA---EEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQ-EATKLKAEAEKLQKQ 2253
Cdd:COG4913    238 ERAHEALEDAREQIELLEpirELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRaELARLEAELERLEAR 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2254 KDQAQEtakRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAqtkAEDEAKKFKKQADEVKA 2333
Cdd:COG4913    318 LDALRE---ELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLP---LPASAEEFAALRAEAAA 391

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1389908296 2334 QLQRTEKHTTEIVVQ--KLETQRLQSTREADDLKSAIAD 2370
Cdd:COG4913    392 LLEALEEELEALEEAlaEAEAALRDLRRELRELEAEIAS 430
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1340-1901 3.96e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.57  E-value: 3.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1340 KQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAA 1419
Cdd:TIGR04523   50 KNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKL 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1420 QDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIR---QIRVVEEV 1496
Cdd:TIGR04523  130 EKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKlelLLSNLKKK 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1497 AQKSaaTQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADK-------LKKQQKEANTAREEAEQELEIWRQK----- 1564
Cdd:TIGR04523  210 IQKN--KSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNtqtqlnqLKDEQNKIKKQLSEKQKELEQNNKKikele 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1565 ------ANEALRLRLQAEEEAQKKSHAQ-EEAEKQKLEAERDAKKRGKA------------EEAALKQKENAEK--ELDK 1623
Cdd:TIGR04523  288 kqlnqlKSEISDLNNQKEQDWNKELKSElKNQEKKLEEIQNQISQNNKIisqlneqisqlkKELTNSESENSEKqrELEE 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1624 QRKFAEQIAQQKLSAEQECIRLKAD-------FEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQ 1696
Cdd:TIGR04523  368 KQNEIEKLKKENQSYKQEIKNLESQindleskIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTN 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1697 mKINAEKASMVNTEKSKQLLESealKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEaEKILKEKLAAINEATRLK 1776
Cdd:TIGR04523  448 -QDSVKELIIKNLDNTRESLET---QLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEE-KKELEEKVKDLTKKISSL 522

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1777 TEAEMALKAKEAENERLKRQAEEE------AYQRKLLEDQAAQHKQDIEEkITQLQTSSDSELGRQKNIVEETLKQKKVV 1850
Cdd:TIGR04523  523 KEKIEKLESEKKEKESKISDLEDElnkddfELKKENLEKEIDEKNKEIEE-LKQTQKSLKKKQEEKQELIDQKEKEKKDL 601

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1851 EEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKK 1901
Cdd:TIGR04523  602 IKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKE 652
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 1341-1636 4.00e-07

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 55.81  E-value: 4.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1341 QKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTtAHKAKSEAELQELRDR----AAEAEKLR 1416
Cdd:pfam15558   18 KEEQRMRELQQQAALAWEELRRRDQKRQETLERERRLLLQQSQEQWQAEKE-QRKARLGREERRRADRrekqVIEKESRW 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1417 KAAQDEAERLRKQ-----VAEETQRKKNAEDELKrksdaEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEkirQIR 1491
Cdd:pfam15558   97 REQAEDQENQRQEkleraRQEAEQRKQCQEQRLK-----EKEEELQALREQNSLQLQERLEEACHKRQLKEREE---QKK 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1492 VVEEVAQKSAATQLQTKAMSFSEQTTK------LEESLKKEQGN--------VLKLQEEADKLKKQQKEANTAREEAEQE 1557
Cdd:pfam15558  169 VQENNLSELLNHQARKVLVDCQAKAEEllrrlsLEQSLQRSQENyeqlveerHRELREKAQKEEEQFQRAKWRAEEKEEE 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1558 LEIWrqkanealrLRLQAEEEAQKKSHAQEEAEKQKLE-AERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKL 1636
Cdd:pfam15558  249 RQEH---------KEALAELADRKIQQARQVAHKTVQDkAQRARELNLEREKNHHILKLKVEKEEKCHREGIKEAIKKKE 319
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1396-1626 4.16e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 55.61  E-value: 4.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1396 AKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELkrksdaekeaaKQKQRALDDLQKykmQAEEA 1475
Cdd:COG3883     12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAEL-----------EALQAEIDKLQA---EIAEA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1476 ERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLE--ESLKKEQGNVLKLQEEA-DKLKKQQKEANTARE 1552
Cdd:COG3883     78 EAEIEERREELGERARALYRSGGSVSYLDVLLGSESFSDFLDRLSalSKIADADADLLEELKADkAELEAKKAELEAKLA 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 1553 EAEQeleiwRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRK 1626
Cdd:COG3883    158 ELEA-----LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAA 226
CH_ACTN2_rpt2 cd21288
second calponin homology (CH) domain found in alpha-actinin-2; Alpha-actinin-2 (ACTN2), also ...
 111-168 4.40e-07

second calponin homology (CH) domain found in alpha-actinin-2; Alpha-actinin-2 (ACTN2), also called alpha-actinin skeletal muscle isoform 2, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN2 is a bundling protein. Its mutations are associated with cardiomyopathies, as well as skeletal muscle disorder. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409137  Cd Length: 124  Bit Score: 51.61  E-value: 4.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21288     53 PDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDiVNTPKPDERAIMTYVSCFY 111
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1387-1603 4.82e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.54  E-value: 4.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQ 1466
Cdd:COG4942     28 ELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 K-----YKMQAEEAERRMKQAEE--EKIRQIRVVEEVAQksaatQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADK 1539
Cdd:COG4942    108 EllralYRLGRQPPLALLLSPEDflDAVRRLQYLKYLAP-----ARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 1540 LKKQQKEANTAREEAEQELEIWRQKANEalrlrLQAEEEAQKKSHAQEEAEKQKLEAERDAKKR 1603
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAE-----LAAELAELQQEAEELEALIARLEAEAAAAAE 241
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4062-4090 4.95e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 48.86  E-value: 4.95e-07
                           10        20
                   ....*....|....*....|....*....
gi 1389908296 4062 IVDPESGKEMSVYEAYQKGLIDHQTYLEL 4090
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
539-631 5.11e-07

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 50.79  E-value: 5.11e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296   539 HAFVVAATKELMWLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAFTA 618
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLE 80

                            90
                    ....*....|...
gi 1389908296   619 ALQTQWSWLLQLC 631
Cdd:smart00150   81 ELNERWEELKELA 93
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1258-2464 5.21e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 56.60  E-value: 5.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1258 NQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEAL--ELKMKMKEEA------- 1328
Cdd:TIGR01612  616 NEYIKKAIDLKKIIENNNAYIDELAKISPYQVPEHLKNKDKIYSTIKSELSKIYEDDIDALynELSSIVKENAidntedk 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1329 SKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIriQLEKTTAHKAKSEAEL-QELRD 1407
Cdd:TIGR01612  696 AKLDDLKSKIDKEYDKIQNMETATVELHLSNIENKKNELLDIIVEIKKHIHGEINK--DLNKILEDFKNKEKELsNKIND 773

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1408 RAAEAEKLRKAAQDEAErLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKykmqaeeAERRMKQAEEEKI 1487
Cdd:TIGR01612  774 YAKEKDELNKYKSKISE-IKNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFK-------IINEMKFMKDDFL 845

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1488 RQIRVVEEVaQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLklQEEADKLKKQQKEANTAREEAEQELEIWRqKANE 1567
Cdd:TIGR01612  846 NKVDKFINF-ENNCKEKIDSEHEQFAELTNKIKAEISDDKLNDY--EKKFNDSKSLINEINKSIEEEYQNINTLK-KVDE 921

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1568 ALRLrLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQK-----ENAEKELDKqrKFAEQIAQQKLSAEQEC 1642
Cdd:TIGR01612  922 YIKI-CENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDKfdntlIDKINELDK--AFKDASLNDYEAKNNEL 998

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1643 IRLKADFehaeqQRGLLDNELQRLKNEVNSTEKQRKQLE---DELNKVRSEMDSLLQMKI-NAEKASMVNTEKSKQLLES 1718
Cdd:TIGR01612  999 IKYFNDL-----KANLGKNKENMLYHQFDEKEKATNDIEqkiEDANKNIPNIEIAIHTSIyNIIDEIEKEIGKNIELLNK 1073

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1719 EALKMKQLAdeAARMRSVAEEAKKQR--QIAEEEAARQRSEAEKI------LKEKL-AAINEATRLKTEAEMALKAKEAE 1789
Cdd:TIGR01612 1074 EILEEAEIN--ITNFNEIKEKLKHYNfdDFGKEENIKYADEINKIkddiknLDQKIdHHIKALEEIKKKSENYIDEIKAQ 1151

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1790 NERLKRQAEEEAYQrklledqaaQHKQDIEEKITQLQTSSDselgRQKNIVEETlkqKKVVEEeihIIKInfhkaSKEKA 1869
Cdd:TIGR01612 1152 INDLEDVADKAISN---------DDPEEIEKKIENIVTKID----KKKNIYDEI---KKLLNE---IAEI-----EKDKT 1207

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1870 DLEselkKLKGIADETQKS--KLKAEEEAEKLKKlaaeeerrrkeaeekvkritaaEEEAARQCKAAQEEVERLKKKAED 1947
Cdd:TIGR01612 1208 SLE----EVKGINLSYGKNlgKLFLEKIDEEKKK----------------------SEHMIKAMEAYIEDLDEIKEKSPE 1261

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1948 ANKQKEKAEKEAEKQVVLakeaaqKCTAAEQKAQDVLSKNKEdvlaqEKLRDEFENAKKLAQEAEKAKEKaekeaallrq 2027
Cdd:TIGR01612 1262 IENEMGIEMDIKAEMETF------NISHDDDKDHHIISKKHD-----ENISDIREKSLKIIEDFSEESDI---------- 1320

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2028 kaeeaekqkkaaeneaakqakaqNDTEKQRkeaeeeaarraaaeaaalkQKQQADAEmsKHKKEAEQALQQKSQVEKELT 2107
Cdd:TIGR01612 1321 -----------------------NDIKKEL-------------------QKNLLDAQ--KHNSDINLYLNEIANIYNILK 1356

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2108 VVKLQ--LDETDKQKVLLDQELQRVKGEVNdafkqKSQVEVELARVRIQMEELvklKLKIEEEnrrLMQKDKDSTQKLLA 2185
Cdd:TIGR01612 1357 LNKIKkiIDEVKEYTKEIEENNKNIKDELD-----KSEKLIKKIKDDINLEEC---KSKIEST---LDDKDIDECIKKIK 1425

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2186 EEaeKMKSLAEEAGRLSV--EAEETARQRQIAESNLAEQRALAEKILK-EKMQAIQEA----TKLKAEAEKLQKQKDQAQ 2258
Cdd:TIGR01612 1426 EL--KNHILSEESNIDTYfkNADENNENVLLLFKNIEMADNKSQHILKiKKDNATNDHdfniNELKEHIDKSKGCKDEAD 1503

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2259 ETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASA-EAEKLKLRVKEL----SLAQTKAEDEAKKFKKQADEVKA 2333
Cdd:TIGR01612 1504 KNAKAIEKNKELFEQYKKDVTELLNKYSALAIKNKFAKTKkDSEIIIKEIKDAhkkfILEAEKSEQKIKEIKKEKFRIED 1583

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2334 QLQRTEKHTTEIV-----VQKLETQRLQST----------READDLKSAIA----DLEEERKKLKKEAEELQRKSKEMAN 2394
Cdd:TIGR01612 1584 DAAKNDKSNKAAIdiqlsLENFENKFLKISdikkkindclKETESIEKKISsfsiDSQDTELKENGDNLNSLQEFLESLK 1663

                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 2395 AQQEQIEQQKAELQQsfLTEKglLLKREKEVEGEKKRFEKQLEDEMKK-AKALKDEQERQRKLMEEERKKL 2464
Cdd:TIGR01612 1664 DQKKNIEDKKKELDE--LDSE--IEKIEIDVDQHKKNYEIGIIEKIKEiAIANKEEIESIKELIEPTIENL 1730
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1309-1879 5.73e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 55.90  E-value: 5.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1309 SVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQeIKSKNQQLEDALVSRRKIEEEIHIIRIQL 1388
Cdd:pfam05557    7 SKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKR-IRLLEKREAEAEEALREQAELNRLKKKYL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1389 EktTAHKAKSEAELQElrdraAEAEKLRKAAQDEAERLRKQVAE---ETQRKKNAEDELKRKSDAEKEAAKQKQRALDDL 1465
Cdd:pfam05557   86 E--ALNKKLNEKESQL-----ADAREVISCLKNELSELRRQIQRaelELQSTNSELEELQERLDLLKAKASEAEQLRQNL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1466 QKYKMQAEEAERRMKQAEEEkirqirvveevAQKSAATQLQTKAMsfseqttkleeslKKEQGNVLKLQEEADKLKKQQK 1545
Cdd:pfam05557  159 EKQQSSLAEAEQRIKELEFE-----------IQSQEQDSEIVKNS-------------KSELARIPELEKELERLREHNK 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1546 EANTAREEAeqelEIWRQKANEaLRLRLQAEEEAQKKShAQEEAEKQKLEAERDA-KKRGKAEEAALKQKENAekeldkq 1624
Cdd:pfam05557  215 HLNENIENK----LLLKEEVED-LKRKLEREEKYREEA-ATLELEKEKLEQELQSwVKLAQDTGLNLRSPEDL------- 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1625 RKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNE-------LQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQM 1697
Cdd:pfam05557  282 SRRIEQLQQREIVLKEENSSLTSSARQLEKARRELEQElaqylkkIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1698 KINAEKaSMVNTEKSKQLLEsealKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRS-----EAEKILKEKLAAINEA 1772
Cdd:pfam05557  362 LESYDK-ELTMSNYSPQLLE----RIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQqaqtlERELQALRQQESLADP 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1773 TRLKTEAEmALKAK----EAENERLKRQAEE---EAYQRKLLEDQ--------------AAQHKQDIEEKITQLQtssdS 1831
Cdd:pfam05557  437 SYSKEEVD-SLRRKletlELERQRLREQKNElemELERRCLQGDYdpkktkvlhlsmnpAAEAYQQRKNQLEKLQ----A 511

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 1389908296 1832 ELGRQKNIVEE-TLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLK 1879
Cdd:pfam05557  512 EIERLKRLLKKlEDDLEQVLRLPETTSTMNFKEVLDLRKELESAELKNQ 560
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1251-1534 6.14e-07

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 56.38  E-value: 6.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1251 SELMTLTNQYIKFIID---AQRRLEDDEKA---SEKLKEEERRKMAEI---QAEL---DKQKQMAEAHAKSVA-KAEQEA 1317
Cdd:NF012221  1538 SESSQQADAVSKHAKQddaAQNALADKERAeadRQRLEQEKQQQLAAIsgsQSQLestDQNALETNGQAQRDAiLEESRA 1617

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1318 L--ELKMKMKE-EASKRQDVAAD----------AEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIeeeihii 1384
Cdd:NF012221  1618 VtkELTTLAQGlDALDSQATYAGesgdqwrnpfAGGLLDRVQEQLDDAKKISGKQLADAKQRHVDNQQKVKDA------- 1690

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1385 riqLEKTTAHKAKSEAELQELRDRAAEAEKlrKAAQDEAERLRKQvaeetQRKKNAEdelkrkSDAEKEAAKQKQRALDD 1464
Cdd:NF012221  1691 ---VAKSEAGVAQGEQNQANAEQDIDDAKA--DAEKRKDDALAKQ-----NEAQQAE------SDANAAANDAQSRGEQD 1754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1465 LQKYKMQAEEAE---RRMKQAEEEKIRQIRV-----------VEEVAQKSAA--TQLQTKAMS-FSEQTTKLE-ESLKKE 1526
Cdd:NF012221  1755 ASAAENKANQAQadaKGAKQDESDKPNRQGAagsglsgkaysVEGVAEPGSHinPDSPAAADGrFSEGLTEQEqEALEGA 1834


                   ....*...
gi 1389908296 1527 QGNVLKLQ 1534
Cdd:NF012221  1835 TNAVNRLQ 1842
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 2227-2512 6.53e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 55.34  E-value: 6.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2227 EKILKEKMQAIQEATKLKAEAEKLQKQKDqAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLR 2306
Cdd:pfam15709  214 ESKAEKKSELISKGKKTGAKRKRTQKERN-LEVAAELSGPDVINSKETEDASERGAFSSDSVVEDPWLSSKYDAEESQVS 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2307 VKELSLAQtkaedeakkfkkQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQ 2386
Cdd:pfam15709  293 IDGRSSPT------------QTFVVTGNMESEEERSEEDPSKALLEKREQEKASRDRLRAERAEMRRLEVERKRREQEEQ 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2387 RKSKEmanAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRfekQLEDEMKKAKALKDEQERQRKLMEEERKKLQA 2466
Cdd:pfam15709  361 RRLQQ---EQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQR---QEEEERKQRLQLQAAQERARQQQEEFRRKLQE 434

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1389908296 2467 IMDEavRKQKEAEEEMKNKQRemdvldkkRLEQEKQLAEENKKLRE 2512
Cdd:pfam15709  435 LQRK--KQQEEAERAEAEKQR--------QKELEMQLAEEQKRLME 470
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2164-2513 7.32e-07

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 55.79  E-value: 7.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2164 KIEEENRRLMQKDKDSTQKLLAEEAEKMKSlaeEAGRLSVEAEETARQRQIAESNlAEQRALAEKILKEKMQ---AIQEA 2240
Cdd:NF033838    69 KILSEIQKSLDKRKHTQNVALNKKLSDIKT---EYLYELNVLKEKSEAELTSKTK-KELDAAFEQFKKDTLEpgkKVAEA 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2241 TKLKAEAEKlqKQKDQAQEtakrlqedkqqiqQRLDKETEGFqKSLEAERkrqleasAEAEkLKLRVKELSLAQTKAEDE 2320
Cdd:NF033838   145 TKKVEEAEK--KAKDQKEE-------------DRRNYPTNTY-KTLELEI-------AESD-VEVKKAELELVKEEAKEP 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2321 AKKFKKQADEVKAQLQRTEKHTTEivvqKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQ--E 2398
Cdd:NF033838   201 RDEEKIKQAKAKVESKKAEATRLE----KIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPatP 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2399 QIEQQKAELQQSFLTEKGL---LLKREKEV-EGEKKRFEKQledemKKAKALKDEQERQ-----RKLMEEE--------- 2460
Cdd:NF033838   277 DKKENDAKSSDSSVGEETLpspSLKPEKKVaEAEKKVEEAK-----KKAKDQKEEDRRNyptntYKTLELEiaesdvkvk 351

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2461 RKKLQAIMDEAVR-----KQKEAEEEMKNKQREMDVLD------KKRLEQEKQLAEENKKLREQ 2513
Cdd:NF033838   352 EAELELVKEEAKEprneeKIKQAKAKVESKKAEATRLEkiktdrKKAEEEAKRKAAEEDKVKEK 415
Caldesmon pfam02029
Caldesmon;
1420-1819 7.35e-07

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 55.26  E-value: 7.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1420 QDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRmkqaeeekirqirvveevaqk 1499
Cdd:pfam02029    4 EEEAARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEE--------------------- 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1500 saatqlqtkamSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKE--ANTAREEAEQELEIWRQKANEALRLRLQAEE 1577
Cdd:pfam02029   63 -----------AFLDRTAKREERRQKRLQEALERQKEFDPTIADEKEsvAERKENNEEEENSSWEKEEKRDSRLGRYKEE 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1578 EAQKKShaQEEAEKQKLEAERDAKKRGKAEEaalkQKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRg 1657
Cdd:pfam02029  132 ETEIRE--KEYQENKWSTEVRQAEEEGEEEE----DKSEEAEEVPTENFAKEEVKDEKIKKEKK---VKYESKVFLDQK- 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1658 lldnelqRLKNEVNStekqrKQLEDELNKVRSEMDSLLQMKINAEKASmvntEKSKQLLESEALKmkqladeaarmrsva 1737
Cdd:pfam02029  202 -------RGHPEVKS-----QNGEEEVTKLKVTTKRRQGGLSQSQERE----EEAEVFLEAEQKL--------------- 250

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1738 EEAKKQRQIAEEEaarqrsEAEKILKEKLAAINEATRLKTEAEMALKAKEAEnERLKRQAEEEAYQRKllEDQAAQHKQD 1817
Cdd:pfam02029  251 EELRRRRQEKESE------EFEKLRQKQQEAELELEELKKKREERRKLLEEE-EQRRKQEEAERKLRE--EEEKRRMKEE 321


                   ..
gi 1389908296 1818 IE 1819
Cdd:pfam02029  322 IE 323
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 2076-2563 7.51e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 55.89  E-value: 7.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEAEQALQQ-KSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEvNDAFKQKS-----QVEVELA 2149
Cdd:pfam15921  306 EQARNQNSMYMRQLSDLESTVSQlRSELREAKRMYEDKIEELEKQLVLANSELTEARTE-RDQFSQESgnlddQLQKLLA 384

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2150 RVRIQMEELVKLKlkieEENRRLMQKDKDSTQKLlaeeaekmkslaeeaGRLSVEAEETARQRQIAESNLAEQRALAEKI 2229
Cdd:pfam15921  385 DLHKREKELSLEK----EQNKRLWDRDTGNSITI---------------DHLRRELDDRNMEVQRLEALLKAMKSECQGQ 445

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2230 LKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQED---KQQIQQRLDKETEGFQKSLEaERKRQLEAS-AEAEKLKL 2305
Cdd:pfam15921  446 MERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEltaKKMTLESSERTVSDLTASLQ-EKERAIEATnAEITKLRS 524

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2306 RV----KELSLAQTKaEDEAKKFKKQADEVKAQLQRTEKhTTEIVVQKLE--TQRL-QSTREADDLKSaiadleeerkkl 2378
Cdd:pfam15921  525 RVdlklQELQHLKNE-GDHLRNVQTECEALKLQMAEKDK-VIEILRQQIEnmTQLVgQHGRTAGAMQV------------ 590

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2379 kkeaeelqrkskEMANAQQEqIEQQKAELQQSfltekgLLLKREKEveGEKKRFEKQLED-EMKKAKALKDEQERQRKLM 2457
Cdd:pfam15921  591 ------------EKAQLEKE-INDRRLELQEF------KILKDKKD--AKIRELEARVSDlELEKVKLVNAGSERLRAVK 649

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2458 EEERKKlqaimDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEK 2537
Cdd:pfam15921  650 DIKQER-----DQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGH 724

                          490       500
                   ....*....|....*....|....*.
gi 1389908296 2538 LVAVtTVGTSKGVLNGSTEVDGVKKE 2563
Cdd:pfam15921  725 AMKV-AMGMQKQITAKRGQIDALQSK 749
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1534-1669 7.70e-07

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 54.88  E-value: 7.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1534 QEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKShAQEEAEKQ-KLEAERDAKKRGKAEEAALK 1612
Cdd:COG2268    210 RETEIAIAQANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAET-ARAEAEAAyEIAEANAEREVQRQLEIAER 288

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1613 QKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADfEHAEQQ----RGLLDNELQRLKNE 1669
Cdd:COG2268    289 EREIELQEKEAEREEAELEADVRKPAEAEKQAAEAE-AEAEAEairaKGLAEAEGKRALAE 348
Caldesmon pfam02029
Caldesmon;
1399-1763 8.58e-07

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 55.26  E-value: 8.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKrksDAEKEAAKQKQRALDDLQKykmQAEEAERR 1478
Cdd:pfam02029    5 EEAARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELK---PSGQGGLDEEEAFLDRTAK---REERRQKR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1479 MKQAEEEkirqirvveevaQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTaREEAEQEl 1558
Cdd:pfam02029   79 LQEALER------------QKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIRE-KEYQENK- 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1559 eiWRQKANealrlrlQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQklsA 1638
Cdd:pfam02029  145 --WSTEVR-------QAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQN---G 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1639 EQECIRLKadFEHAEQQRGLLDNELQRLKNEV-----NSTEKQRKQLEDelnKVRSEMDSLLQMKINAE------KASMv 1707
Cdd:pfam02029  213 EEEVTKLK--VTTKRRQGGLSQSQEREEEAEVfleaeQKLEELRRRRQE---KESEEFEKLRQKQQEAEleleelKKKR- 286

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1708 ntEKSKQLLESEALKMKQLADEaarmRSVAEEAKKQRQiaEEEAARQRSEA-EKILK 1763
Cdd:pfam02029  287 --EERRKLLEEEEQRRKQEEAE----RKLREEEEKRRM--KEEIERRRAEAaEKRQK 335
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1652-1822 8.94e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.39  E-value: 8.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1652 AEQQRGLLDneLQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQmKINAEKASMVNTEKSKQLLESEalkMKQLADEAA 1731
Cdd:COG1579      3 PEDLRALLD--LQELDSELDRLEHRLKELPAELAELEDELAALEA-RLEAAKTELEDLEKEIKRLELE---IEEVEARIK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1732 RMRSVAEEAKKQRQIA-----EEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKL 1806
Cdd:COG1579     77 KYEEQLGNVRNNKEYEalqkeIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEA 156

                          170
                   ....*....|....*.
gi 1389908296 1807 LEDQAAQHKQDIEEKI 1822
Cdd:COG1579    157 ELEELEAEREELAAKI 172
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2025-2529 1.03e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.16  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2025 LRQKAEEAEKQKKAAENEAAKQAKAQndtEKQRKEAEeeaarraaaeaaalkqkqqadaemsKHKKEAEQALQQKSQVEK 2104
Cdd:COG4717     51 LEKEADELFKPQGRKPELNLKELKEL---EEELKEAE-------------------------EKEEEYAELQEELEELEE 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2105 ELTVVKLQLDETDKQKVLLDQELQRVkgevnDAFKQKSQVEVELARVRIQMEElvkLKLKIEEENRRLMQKdkdstQKLL 2184
Cdd:COG4717    103 ELEELEAELEELREELEKLEKLLQLL-----PLYQELEALEAELAELPERLEE---LEERLEELRELEEEL-----EELE 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2185 AEEAEKMKSLAEEAGRLSVEAEETARQrqiaesnLAEQRalaEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRL 2264
Cdd:COG4717    170 AELAELQEELEELLEQLSLATEEELQD-------LAEEL---EELQQRLAELEEELEEAQEELEELEEELEQLENELEAA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2265 QEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAE-AEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRtekhtt 2343
Cdd:COG4717    240 ALEERLKEARLLLLIAAALLALLGLGGSLLSLILTiAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPAL------ 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2344 eivvQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQ--QEQIEQQKAELQQSF-------LTE 2414
Cdd:COG4717    314 ----EELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEElqLEELEQEIAALLAEAgvedeeeLRA 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2415 KGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRklMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDK 2494
Cdd:COG4717    390 ALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEE--LEEELEELEEELEELEEELEELREELAELEAELEQLEE 467

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1389908296 2495 -----KRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKE 2529
Cdd:COG4717    468 dgelaELLQELEELKAELRELAEEWAALKLALELLEEARE 507
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1241-1620 1.08e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.16  E-value: 1.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1241 QEYVNLRTRYSELMTLTNQyIKFIIDAQRRLEDDEKASEKLKEEERR------KMAEIQAELDKQKQMAEAHAKSVAKAE 1314
Cdd:COG4717    102 EELEELEAELEELREELEK-LEKLLQLLPLYQELEALEAELAELPERleeleeRLEELRELEEELEELEAELAELQEELE 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1315 QEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQ------- 1387
Cdd:COG4717    181 ELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ----EELEELEEELEQLENELEAAALEERLKEARlllliaa 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1388 ----LEKTTAHKAKSEAELQEL-----------RDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEK 1452
Cdd:COG4717    257 allaLLGLGGSLLSLILTIAGVlflvlgllallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSP 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1453 EAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQ-----IRVVEEVAQKSAATQLQtKAMSFSEQTTKLEESLKKEQ 1527
Cdd:COG4717    337 EELLELLDRIEELQELLREAEELEEELQLEELEQEIAallaeAGVEDEEELRAALEQAE-EYQELKEELEELEEQLEELL 415

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1528 GNVLKLQEEADK--LKKQQKEANTAREEAEQELEIWRQK--ANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKR 1603
Cdd:COG4717    416 GELEELLEALDEeeLEEELEELEEELEELEEELEELREElaELEAELEQLEEDGELAELLQELEELKAELRELAEEWAAL 495

                          410
                   ....*....|....*..
gi 1389908296 1604 GKAEEAALKQKENAEKE 1620
Cdd:COG4717    496 KLALELLEEAREEYREE 512
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1617-1813 1.19e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 54.07  E-value: 1.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1617 AEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQ 1696
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERAR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1697 -MKINAEKASMVNtekskQLLESEAL---------------KMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEK 1760
Cdd:COG3883     94 aLYRSGGSVSYLD-----VLLGSESFsdfldrlsalskiadADADLLEELKADKAELEAKKAELEAKLAELEALKAELEA 168

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1761 ILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQ 1813
Cdd:COG3883    169 AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2076-2267 1.21e-06

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 54.43  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEAEQA--LQQKSQVE----KELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAfkQKSQVEVELA 2149
Cdd:PRK09510    70 QQKSAKRAEEQRKKKEQQQAeeLQQKQAAEqerlKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEA--AAKAAAAAKA 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2150 RVRIQMEELVKLKLKIEEENRRLMQKDKDSTQ----KLLAEEAEKMKSLAEEAGRLSVEAEETARQrqiaesnLAEQRAL 2225
Cdd:PRK09510   148 KAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAaaeaKKKAEAEAAAKAAAEAKKKAEAEAKKKAAA-------EAKKKAA 220

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1389908296 2226 AEKilkeKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQED 2267
Cdd:PRK09510   221 AEA----KAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
CH_FLN_rpt2 cd21230
second calponin homology (CH) domain found in filamins; The filamin family includes filamin-A ...
 125-165 1.31e-06

second calponin homology (CH) domain found in filamins; The filamin family includes filamin-A (FLN-A), filamin-B (FLN-B) and filamin-C (FLN-C). Filamins function to anchor various transmembrane proteins to the actin cytoskeleton. FLN-A is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-B is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton and may also promote orthogonal branching of actin filaments as well as link actin filaments to membrane glycoproteins. FLN-C, also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Members of this family contain two copies of the CH domain. The model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409079  Cd Length: 103  Bit Score: 49.69  E-value: 1.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1389908296  125 QENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVS 165
Cdd:cd21230     56 LENATEAMQLAEDWLGVPQLITPEEIINPNVDEMSVMTYLS 96
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1390-1687 1.31e-06

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 54.76  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1390 KTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSD----AEKEAAKQKQRALDDL 1465
Cdd:pfam09731   94 QSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDdaiqAVKAHTDSLKEASDTA 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1466 QKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTkleESLKKEQGNVLKLQEEADKLKKQQK 1545
Cdd:pfam09731  174 EISREKATDSALQKAEALAEKLKEVINLAKQSEEEAAPPLLDAAPETPPKLP---EHLDNVEEKVEKAQSLAKLVDQYKE 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1546 EANTAREEAEQELE---------------IWRQKAN----------EALRLRLQaEEEAQKKSHAQEEAEKQKLE----- 1595
Cdd:pfam09731  251 LVASERIVFQQELVsifpdiipvlkednlLSNDDLNsliahahreiDQLSKKLA-ELKKREEKHIERALEKQKEEldkla 329

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1596 -----------AERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLS---AEQEcIRLKADF-----EHAEQQR 1656
Cdd:pfam09731  330 eelsarleevrAADEAQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKdvlVEQE-IELQREFlqdikEKVEEER 408

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1389908296 1657 GLLDNELQRLKNEVNSTEKQ---RKQLEDELNKV 1687
Cdd:pfam09731  409 AGRLLKLNELLANLKGLEKAtssHSEVEDENRKA 442
mukB PRK04863
chromosome partition protein MukB;
2163-2518 1.32e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.96  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2163 LKIEEENRRL------MQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLA---EQRALAEKI---- 2229
Cdd:PRK04863   275 MRHANERRVHleealeLRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNlvqTALRQQEKIeryq 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2230 ---------LKEKMQAIQEATKLKAEAEKlqkQKDQAQETAKRLQEDKQQIQQRLD---KETEGFQKSLEA-ERKRQL-- 2294
Cdd:PRK04863   355 adleeleerLEEQNEVVEEADEQQEENEA---RAEAAEEEVDELKSQLADYQQALDvqqTRAIQYQQAVQAlERAKQLcg 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2295 EASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKhtTEIVVQKL--ETQRLQSTREAddlKSAIADLE 2372
Cdd:PRK04863   432 LPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQ--AYQLVRKIagEVSRSEAWDVA---RELLRRLR 506

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2373 EERKKLKKEAEELQRkskeMANAQQEQIEQQKAE-LQQSFLTEKGLLLKREKEVEGEKKRFEKQLED---EMKKAKALKD 2448
Cdd:PRK04863   507 EQRHLAEQLQQLRMR----LSELEQRLRQQQRAErLLAEFCKRLGKNLDDEDELEQLQEELEARLESlseSVSEARERRM 582

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2449 EQERQRKLMEEERKKLQAI------MDEAV-RKQKEAEEEMKNKQREMDVLdKKRLEQEKQLAEENKKLREQLQTFE 2518
Cdd:PRK04863   583 ALRQQLEQLQARIQRLAARapawlaAQDALaRLREQSGEEFEDSQDVTEYM-QQLLERERELTVERDELAARKQALD 658
Caldesmon pfam02029
Caldesmon;
2125-2482 1.34e-06

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 54.49  E-value: 1.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2125 QELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEENRRL---MQKDKDSTQKLLAEEAEKMKSLAEEAGRL 2201
Cdd:pfam02029   17 EERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFldrTAKREERRQKRLQEALERQKEFDPTIADE 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2202 SVEAEETARQRQIAESNLAEQRalaEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQqiqqrldketeg 2281
Cdd:pfam02029   97 KESVAERKENNEEEENSSWEKE---EKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEED------------ 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2282 fqKSLEAERKRQLEASAEAEKLKLRVKELslaqtKAEDEAKKF---KKQADEVKAQlqRTEKHTTEIVVQKLETQRLQST 2358
Cdd:pfam02029  162 --KSEEAEEVPTENFAKEEVKDEKIKKEK-----KVKYESKVFldqKRGHPEVKSQ--NGEEEVTKLKVTTKRRQGGLSQ 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2359 READDLKSAiadlEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELqqsfltEKGLLLKREKEVEGEKKRFEKQLED 2438
Cdd:pfam02029  233 SQEREEEAE----VFLEAEQKLEELRRRRQEKESEEFEKLRQKQQEAEL------ELEELKKKREERRKLLEEEEQRRKQ 302

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1389908296 2439 EMKKAKALKDEQERQRKlMEEERKKLQAimdeAVRKQKEAEEEM 2482
Cdd:pfam02029  303 EEAERKLREEEEKRRMK-EEIERRRAEA----AEKRQKLPEDSS 341
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 2133-2321 1.41e-06

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 54.24  E-value: 1.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2133 EVNDAFKQKSQVEVELARVRIQMEELvklklKIEEENRRLMQKDKDSTQKllAEEAEKMKSLAEEAGRLSVEAEETARQR 2212
Cdd:pfam05262  181 KVVEALREDNEKGVNFRRDMTDLKER-----ESQEDAKRAQQLKEELDKK--QIDADKAQQKADFAQDNADKQRDEVRQK 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2213 QIAESNLAEQRALAEKILKEKMQAIQeatklKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGF--QKSLEAER 2290
Cdd:pfam05262  254 QQEAKNLPKPADTSSPKEDKQVAENQ-----KREIEKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEaeDKELEAQK 328

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1389908296 2291 KRqLEASAEAEKLKLRVKelslAQTKAEDEA 2321
Cdd:pfam05262  329 KR-EPVAEDLQKTKPQVE----AQPTSLNED 354
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1893-2280 1.50e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 54.13  E-value: 1.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1893 EEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQK 1972
Cdd:pfam07888   37 EECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1973 ctaaeqkaQDVLSKNKEDvlAQEKLRDEFENAKKLAQEAEKAKEKAEKeaalLRQKAEEAEKQKKAAENE-AAKQAKAQN 2051
Cdd:pfam07888  117 --------KDALLAQRAA--HEARIRELEEDIKTLTQRVLERETELER----MKERAKKAGAQRKEEEAErKQLQAKLQQ 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2052 dTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKkeaeQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVK 2131
Cdd:pfam07888  183 -TEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT----QKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLG 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2132 GEVNDAFKQKSQVEVELARVRIQMEE----LVKLKLKIEEENRRlMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEE 2207
Cdd:pfam07888  258 EELSSMAAQRDRTQAELHQARLQAAQltlqLADASLALREGRAR-WAQERETLQQSAEADKDRIEKLSAELQRLEERLQE 336

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2208 TARQRQIAESNLAEQRALAEKILKEKMQAIQEatkLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETE 2280
Cdd:pfam07888  337 ERMEREKLEVELGREKDCNRVQLSESRRELQE---LKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVAD 406
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2025-2515 1.60e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.54  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2025 LRQKAEEAEKQKKA---AENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQA-DAEMSKHKKEAEQALQQKS 2100
Cdd:COG4913    240 AHEALEDAREQIELlepIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEElRAELARLEAELERLEARLD 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2101 QVEKELTVVKLQLDETDkqkvllDQELQRVKGEVNDAFKQKSQVEVELARvriQMEELVKLKLKIEEEnRRLMQKDKDST 2180
Cdd:COG4913    320 ALREELDELEAQIRGNG------GDRLEQLEREIERLERELEERERRRAR---LEALLAALGLPLPAS-AEEFAALRAEA 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2181 QKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKI---LKEKMQAIQEATKLKAE-----AEKLQ- 2251
Cdd:COG4913    390 AALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparLLALRDALAEALGLDEAelpfvGELIEv 469

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2252 KQKDQAQETA----------------KRLQE-----DKQQIQQRLDkeTEGFQKSLEAERKRQLEASAEAEKLKLRVKEL 2310
Cdd:COG4913    470 RPEEERWRGAiervlggfaltllvppEHYAAalrwvNRLHLRGRLV--YERVRTGLPDPERPRLDPDSLAGKLDFKPHPF 547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2311 S------LAQTKA------EDEAKKFKK---QADEVKAQLQRTEKHTTEIV-------------VQKLETQRLQSTREAD 2362
Cdd:COG4913    548 RawleaeLGRRFDyvcvdsPEELRRHPRaitRAGQVKGNGTRHEKDDRRRIrsryvlgfdnrakLAALEAELAELEEELA 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2363 DLKSAIADLEEERKKLKKEAEELQRKSK--------EMANAQQEQIEQQKAELQQSF--LTEkglLLKREKEVEGEKKRF 2432
Cdd:COG4913    628 EAEERLEALEAELDALQERREALQRLAEyswdeidvASAEREIAELEAELERLDASSddLAA---LEEQLEELEAELEEL 704

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2433 EKQLEDEMKKAKALKDEQERqrklMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLRE 2512
Cdd:COG4913    705 EEELDELKGEIGRLEKELEQ----AEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRA 780


                   ...
gi 1389908296 2513 QLQ 2515
Cdd:COG4913    781 RLN 783
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1165-1598 1.60e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1165 ISDSRALREQLTDEKKLLGEIEKNKDKIDDCHKNAKAYIDSVKDyefQILTYKALQDPIASPL--KKPKMECASDDIIQE 1242
Cdd:TIGR04523  210 IQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQT---QLNQLKDEQNKIKKQLseKQKELEQNNKKIKEL 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1243 YVNLRTRYSELMTLTNQYIKfiiDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKM 1322
Cdd:TIGR04523  287 EKQLNQLKSEISDLNNQKEQ---DWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQR 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1323 KMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSD--QEIKSKNQQLEDALvsrRKIEEEIHIIRIQLEKTTAHKAKSEA 1400
Cdd:TIGR04523  364 ELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESkiQNQEKLNQQKDEQI---KKLQQEKELLEKEIERLKETIIKNNS 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1401 ELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKsdaeKEAAKQKQRALDDLQKYKMQAEEAERRMK 1480
Cdd:TIGR04523  441 EIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQK----QKELKSKEKELKKLNEEKKELEEKVKDLT 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1481 QAEEEKIRQIRVVEevaqkSAATQLQTKAMSFSEQTTKLEESLKKEQ--GNVLKLQEEADKLKKQQKEANTAREEAEQEL 1558
Cdd:TIGR04523  517 KKISSLKEKIEKLE-----SEKKEKESKISDLEDELNKDDFELKKENleKEIDEKNKEIEELKQTQKSLKKKQEEKQELI 591

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1389908296 1559 EiwrQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAER 1598
Cdd:TIGR04523  592 D---QKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEK 628
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1403-1705 1.66e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.84  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1403 QELRDRAAEAEKLRKAAQDEAERLRKQVA------EETQRK--------KNAEDELKRKSDAEKEAAKQKQRALddlqky 1468
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVqangelEKASREetfartalKNARLDLRRLFDEKQSEKDKKNKAL------ 673

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1469 kmqaeeaERRMKQAEeekirqirvveevaqksaatqlqtkamsfsEQTTKLEESLKKeqgNVLKLQEEADKLKKQQKEAN 1548
Cdd:pfam12128  674 -------AERKDSAN------------------------------ERLNSLEAQLKQ---LDKKHQAWLEEQKEQKREAR 713

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1549 TAREEAEQELEIWRQKANEALRLRLQAEEEAQKkshAQEEAEKQklEAERDAKKRGKAEEAALKQK---ENAEKELDKQR 1625
Cdd:pfam12128  714 TEKQAYWQVVEGALDAQLALLKAAIAARRSGAK---AELKALET--WYKRDLASLGVDPDVIAKLKreiRTLERKIERIA 788

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1626 KFAEQIAQ----QKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEV-----------NSTEKQRKQLEDELNKVRSE 1690
Cdd:pfam12128  789 VRRQEVLRyfdwYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTklrraklemerKASEKQQVRLSENLRGLRCE 868

                          330
                   ....*....|....*
gi 1389908296 1691 MDSLLQMKINAEKAS 1705
Cdd:pfam12128  869 MSKLATLKEDANSEQ 883
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1349-1683 1.80e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 54.13  E-value: 1.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1349 LQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRK 1428
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1429 QVAEEtqrkknaedelKRKSDAEKEAAKQKQRALDDLQK---YKMQAEEAE-RRMKQAEEEKIRQIRVVEEVAQKSAATQ 1504
Cdd:pfam07888  112 ELSEE-----------KDALLAQRAAHEARIRELEEDIKtltQRVLERETElERMKERAKKAGAQRKEEEAERKQLQAKL 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1505 LQTKA--MSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWR---------QKANEALRLRL 1573
Cdd:pfam07888  181 QQTEEelRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRslqerlnasERKVEGLGEEL 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1574 qaEEEAQKKSHAQEEAEKQKLEAE-------------RDAKKRGKAEEAALKQkeNAEKELDKQRKFAEQIAQ-QKLSAE 1639
Cdd:pfam07888  261 --SSMAAQRDRTQAELHQARLQAAqltlqladaslalREGRARWAQERETLQQ--SAEADKDRIEKLSAELQRlEERLQE 336

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1640 QECIRLKADFEHAEQ------QRGLLDNELQRLKNEVNSTEKQRKQLEDE 1683
Cdd:pfam07888  337 ERMEREKLEVELGREkdcnrvQLSESRRELQELKASLRVAQKEKEQLQAE 386
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 2198-2540 2.14e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 53.99  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2198 AGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKL----------KAEAEKLQKQKDQAQETAKRLQED 2267
Cdd:pfam07111   58 SQALSQQAELISRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELdalavaekagQAEAEGLRAALAGAEMVRKNLEEG 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2268 KQQI--------QQRLDKETEGFQKSLE--AERKRQLEASAEAEKLKL--RVKELSLAQTKAEDEAKKFKKQADEVKAQL 2335
Cdd:pfam07111  138 SQREleeiqrlhQEQLSSLTQAHEEALSslTSKAEGLEKSLNSLETKRagEAKQLAEAQKEAELLRKQLSKTQEELEAQV 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2336 QRTE---KHTTEIVVQKLETQRLQSTREA--DDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIE--QQKAELQ 2408
Cdd:pfam07111  218 TLVEslrKYVGEQVPPEVHSQTWELERQEllDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRkiQPSDSLE 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2409 QSFLTEKGLLLKREKE-VEGEKKRFEKQLEDEMKKAKALKDE-QERQRKLMEEERKklQAIMDEAVR-KQKEAEEE---M 2482
Cdd:pfam07111  298 PEFPKKCRSLLNRWREkVFALMVQLKAQDLEHRDSVKQLRGQvAELQEQVTSQSQE--QAILQRALQdKAAEVEVErmsA 375

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2483 KNKQREMDVLDKKRLEQEKQLAEENKKLReqlqtFEISSKTVSQTK-ESQTVSVEKLVA 2540
Cdd:pfam07111  376 KGLQMELSRAQEARRRQQQQTASAEEQLK-----FVVNAMSSTQIWlETTMTRVEQAVA 429
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1265-1573 2.17e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 53.00  E-value: 2.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1265 IDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQN 1344
Cdd:pfam13868   45 LDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEK 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1345 IQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAE 1424
Cdd:pfam13868  125 QRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERD 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1425 RLRKQVAEETQRKKNAEdelkrksdAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQ 1504
Cdd:pfam13868  205 ELRAKLYQEEQERKERQ--------KEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEI 276

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1505 LQtkamsfsEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRL 1573
Cdd:pfam13868  277 EQ-------EEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 996-1886 2.27e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 54.28  E-value: 2.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  996 LTLKKMEQVYGLSSVYLDKLKTVDVVIRNTADAEEtlkNYEARLRDVSK--------VPSEQKEVEKHRSQMKSMRSEAE 1067
Cdd:TIGR00606  196 QTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKE---AQLESSREIVKsyeneldpLKNRLKEIEHNLSKIMKLDNEIK 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1068 ADQVMFDRLQDDLRKATTVHDKMTRIHSERDADLEHYRQLVNGLLERwqaVFAQIELRLRELDLLGRHMNSYRDSYEWLI 1147
Cdd:TIGR00606  273 ALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKER---ELVDCQRELEKLNKERRLLNQEKTELLVEQ 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1148 RWLT-EARQRQEKIQAvpiSDSRALREQLTDEKKLLGEIEKNKDKIDDCHK--------NAKAYIDSVKDYEFQILTYKA 1218
Cdd:TIGR00606  350 GRLQlQADRHQEHIRA---RDSLIQSLATRLELDGFERGPFSERQIKNFHTlvierqedEAKTAAQLCADLQSKERLKQE 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1219 LQDPIasplkKPKMECASDDIIQEYVNLRTRYSELmtltnqyiKFIIDAQRRLEDDEKASEKLKEEERRKMAEIqaELDK 1298
Cdd:TIGR00606  427 QADEI-----RDEKKGLGRTIELKKEILEKKQEEL--------KFVIKELQQLEGSSDRILELDQELRKAEREL--SKAE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1299 QKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQniQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIE 1378
Cdd:TIGR00606  492 KNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQ--MEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYF 569

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1379 EEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQR------KKNAEDELKRKSDAEK 1452
Cdd:TIGR00606  570 PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKlfdvcgSQDEESDLERLKEEIE 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1453 EAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSaaTQLQTKAMSFSEQTTKLEESLKKE------ 1526
Cdd:TIGR00606  650 KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFI--SDLQSKLRLAPDKLKSTESELKKKekrrde 727

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1527 -------QGNVL--------KLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRL--------RLQAEEEAQKKS 1583
Cdd:TIGR00606  728 mlglapgRQSIIdlkekeipELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCltdvtimeRFQMELKDVERK 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1584 HAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKAD---FEHAEQQRGLLD 1660
Cdd:TIGR00606  808 IAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEklqIGTNLQRRQQFE 887

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1661 NELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMkiNAEKASMVNTEKSKQLLESEALKmKQLADEAARMRSVAEEa 1740
Cdd:TIGR00606  888 EQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQE--KEELISSKETSNKKAQDKVNDIK-EKVKNIHGYMKDIENK- 963

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1741 kkqrqiAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEmalkakeaENERLKRQAEEEAYQR-KLLEDQAAQHKqdIE 1819
Cdd:TIGR00606  964 ------IQDGKDDYLKQKETELNTVNAQLEECEKHQEKIN--------EDMRLMRQDIDTQKIQeRWLQDNLTLRK--RE 1027

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1820 EKITQLQTSSDSELGR--QKNIVEETLKQKKvVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQ 1886
Cdd:TIGR00606 1028 NELKEVEEELKQHLKEmgQMQVLQMKQEHQK-LEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQ 1095
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1401-1875 2.40e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.15  E-value: 2.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1401 ELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAE-DELKRKSDAEKEAAKQKQRALDDLQKYKMQA-----EE 1474
Cdd:COG4913    263 RYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAElARLEAELERLEARLDALREELDELEAQIRGNggdrlEQ 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1475 AERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAM--SFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTARE 1552
Cdd:COG4913    343 LEREIERLERELEERERRRARLEALLAALGLPLPASaeEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELR 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1553 EAEQELEIWRQKAN----EALRLRLQAEEEAQKKS------------HAQEE-----AEK-------------------- 1591
Cdd:COG4913    423 ELEAEIASLERRKSnipaRLLALRDALAEALGLDEaelpfvgelievRPEEErwrgaIERvlggfaltllvppehyaaal 502

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1592 --------------QKLEAERDAKKRGKAEEAALKQK----EN-----AEKELDKQRKFA-----EQIAQQKLSAEQEC- 1642
Cdd:COG4913    503 rwvnrlhlrgrlvyERVRTGLPDPERPRLDPDSLAGKldfkPHpfrawLEAELGRRFDYVcvdspEELRRHPRAITRAGq 582

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1643 IRLKAD-FEHAEQQRGLLDNELQRlknevnSTEKQRKQLEDELNKVRSEMDSLlqmkinaekasmvntEKSKQLLESEAL 1721
Cdd:COG4913    583 VKGNGTrHEKDDRRRIRSRYVLGF------DNRAKLAALEAELAELEEELAEA---------------EERLEALEAELD 641

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1722 KMKQLADEAARMRSVAEEAKKQRQIAEEEAArqrseaekiLKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEA 1801
Cdd:COG4913    642 ALQERREALQRLAEYSWDEIDVASAEREIAE---------LEAELERLDASSDDLAALEEQLEELEAELEELEEELDELK 712

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1802 YQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQ---KKVVEEEIHIIKINFHKASKEKADLESEL 1875
Cdd:COG4913    713 GEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAalgDAVERELRENLEERIDALRARLNRAEEEL 789
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1753-2361 2.66e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 53.89  E-value: 2.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1753 RQRSEAEKILKEKLAAINEatrlKTEAEMALKAKEAENERLKRQAEEEAYQRKllEDQAAQHKQDIEEKITQLqtssdse 1832
Cdd:PRK02224   180 RVLSDQRGSLDQLKAQIEE----KEEKDLHERLNGLESELAELDEEIERYEEQ--REQARETRDEADEVLEEH------- 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1833 lgrqknivEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEklkklaaeeerrrke 1912
Cdd:PRK02224   247 --------EERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAG--------------- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1913 aeekvkrITAAEEEAArqcKAAQEEVERLKKKAEDAnkqkekaekeAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVL 1992
Cdd:PRK02224   304 -------LDDADAEAV---EARREELEDRDEELRDR----------LEECRVAAQAHNEEAESLREDADDLEERAEELRE 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1993 AQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEa 2072
Cdd:PRK02224   364 EAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERV- 442

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2073 aalkQKQQADAEMSKHkKEAEQALQQKSQVEKeltvvklqLDETDKQKVLLDQELQRVKGEVNDafkqksqVEVELARVr 2152
Cdd:PRK02224   443 ----EEAEALLEAGKC-PECGQPVEGSPHVET--------IEEDRERVEELEAELEDLEEEVEE-------VEERLERA- 501

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2153 iqmEELVKLKLKIE--EENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNlAEQRALAEKIL 2230
Cdd:PRK02224   502 ---EDLVEAEDRIErlEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEE-AEEAREEVAEL 577

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2231 KEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKslEAERKRQLEASAEA---EKLKLRV 2307
Cdd:PRK02224   578 NSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAE--KRERKRELEAEFDEariEEAREDK 655

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2308 KELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREA 2361
Cdd:PRK02224   656 ERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEA 709
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1989-2473 3.05e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.62  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1989 EDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRA 2068
Cdd:COG4717     48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2069 AAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKV-LLDQELQRVKGEVNDAFKQKSQVEVE 2147
Cdd:COG4717    128 LPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEeLLEQLSLATEEELQDLAEELEELQQR 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2148 LARVRiqmEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAE 2227
Cdd:COG4717    208 LAELE---EELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLG 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2228 KILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLE-AERKRQLEASAEAEKLKLR 2306
Cdd:COG4717    285 LLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDrIEELQELLREAEELEEELQ 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2307 VKE--------LSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLeeerkkl 2378
Cdd:COG4717    365 LEEleqeiaalLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEEL------- 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2379 kkeaeelqRKSKEMANAQQEQIEQQKAELQQ--SFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKL 2456
Cdd:COG4717    438 --------EEELEELEEELEELREELAELEAelEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEY 509

                          490
                   ....*....|....*..
gi 1389908296 2457 MEEerkKLQAIMDEAVR 2473
Cdd:COG4717    510 REE---RLPPVLERASE 523
PRK07735 PRK07735
NADH-quinone oxidoreductase subunit C;
1399-1655 3.40e-06

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 236081 [Multi-domain]  Cd Length: 430  Bit Score: 53.06  E-value: 3.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELRDRAAEAEKLRkAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERR 1478
Cdd:PRK07735     4 EKDLEDLKKEAARRAKEE-ARKRLVAKHGAEISKLEEENREKEKALPKNDDMTIEEAKRRAAAAAKAKAAALAKQKREGT 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1479 MKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQEL 1558
Cdd:PRK07735    83 EEVTEEEKAKAKAKAAAAAKAKAAALAKQKREGTEEVTEEEKAAAKAKAAAAAKAKAAALAKQKREGTEEVTEEEEETDK 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1559 EIWRQKANEALRLR---LQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAAL-KQKEN-----AEKELDKQRKFAE 1629
Cdd:PRK07735   163 EKAKAKAAAAAKAKaaaLAKQKAAEAGEGTEEVTEEEKAKAKAKAAAAAKAKAAALaKQKASqgngdSGDEDAKAKAIAA 242

                          250       260
                   ....*....|....*....|....*.
gi 1389908296 1630 QIAQQKLSAEQECIRLKADFEHAEQQ 1655
Cdd:PRK07735   243 AKAKAAAAARAKTKGAEGKKEEEPKQ 268
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1979-2263 3.47e-06

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 53.11  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1979 KAQDVLSKNKEDvLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEK--- 2055
Cdd:pfam05667  204 VVPSLLERNAAE-LAAAQEWEEEWNSQGLASRLTPEEYRKRKRTKLLKRIAEQLRSAALAGTEATSGASRSAQDLAElls 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2056 ------QRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSqvEKELTVVKLQLDETDKQKVLLDQELQR 2129
Cdd:pfam05667  283 sfsgssTTDTGLTKGSRFTHTEKLQFTNEAPAATSSPPTKVETEEELQQQR--EEELEELQEQLEDLESSIQELEKEIKK 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2130 VKGEVndafkqkSQVEVELARVRIQMEEL---VKLK------LKIEEENRRLMQKD-KDSTQKL--LAEEAEKMKS-LAE 2196
Cdd:pfam05667  361 LESSI-------KQVEEELEELKEQNEELekqYKVKkktldlLPDAEENIAKLQALvDASAQRLveLAGQWEKHRVpLIE 433

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2197 EAGRLSVeaeetarqrQIAESNLAEQRALAE-KILKEKMQAIQEATKLKAEAEK-LQKQKDQAQETAKR 2263
Cdd:pfam05667  434 EYRALKE---------AKSNKEDESQRKLEEiKELREKIKEVAEEAKQKEELYKqLVAEYERLPKDVSR 493
CH_EHBP cd21198
calponin homology (CH) domain found in the EH domain-binding protein (EHBP) family; The EHBP ...
 111-168 3.53e-06

calponin homology (CH) domain found in the EH domain-binding protein (EHBP) family; The EHBP family includes EHBP1 and EHBP1-like protein (EHBP1L1). EHBP1 is a regulator of endocytic recycling and may play a role in actin reorganization by linking clathrin-mediated endocytosis to the actin cytoskeleton. It may act as an effector of small GTPases, including RAB-10 (Rab10), and play a role in vesicle trafficking. EHBP1 is associated with aggressive prostate cancer and insulin-stimulated trafficking and cell migration. EHBP1L1 may also act as Rab effector protein and play a role in vesicle trafficking. It coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409047  Cd Length: 105  Bit Score: 48.58  E-value: 3.53e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAErELGVTKLLDPEDV---DVphPDEKSIITYVSSLY 168
Cdd:cd21198     44 PDLIDFSSLSPHDIKENCKLAFDAAA-KLGIPRLLDPADMvllSV--PDKLSVMTYLHQIR 101
Rabaptin pfam03528
Rabaptin;
1404-1790 3.81e-06

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 52.80  E-value: 3.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1404 ELRDRAAEAEKLRKaaqdEAERLRKQVAEETQRKK--------NAEDELKRKSDAEKEAakqkQRALDDLQKYKMQAeea 1475
Cdd:pfam03528    5 DLQQRVAELEKENA----EFYRLKQQLEAEFNQKRakfkelylAKEEDLKRQNAVLQEA----QVELDALQNQLALA--- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1476 errmkQAEEEKIRQIRVVEEVAQKSAATQLQTKamsFSEQTTKLEeSLKKEQGNVLKLQEEAdKLKKQQKEANTAREEAE 1555
Cdd:pfam03528   74 -----RAEMENIKAVATVSENTKQEAIDEVKSQ---WQEEVASLQ-AIMKETVREYEVQFHR-RLEQERAQWNQYRESAE 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1556 QELEIWRQKANEAlrlrlQAEEEAQKK-SHAQEEAEKQkleaeRDAKKRGKAEEAALKQK-ENAEKELDKQRKFAEQIAQ 1633
Cdd:pfam03528  144 REIADLRRRLSEG-----QEEENLEDEmKKAQEDAEKL-----RSVVMPMEKEIAALKAKlTEAEDKIKELEASKMKELN 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1634 QKLSAEQECirlKADFEhaeQQRGLLDNELQRLKNEvnsTEKQRKQLEDELNKVRSEMDSLLQMKINAEKAsmvntekSK 1713
Cdd:pfam03528  214 HYLEAEKSC---RTDLE---MYVAVLNTQKSVLQED---AEKLRKELHEVCHLLEQERQQHNQLKHTWQKA-------ND 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1714 QLLESEALKMKQLadeaARMRSV--------AEEAKKQRQIAEEEA-ARQRSEAEKILKEKLAAINEATRLKTEAEMALK 1784
Cdd:pfam03528  278 QFLESQRLLMRDM----QRMESVltseqlrqVEEIKKKDQEEHKRArTHKEKETLKSDREHTVSIHAVFSPAGVETSAPL 353


                   ....*.
gi 1389908296 1785 AKEAEN 1790
Cdd:pfam03528  354 SNVEEQ 359
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1239-1896 4.14e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 53.54  E-value: 4.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1239 IIQEYVNLRTRYSEL--MTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKqkqmAEAHAKSVAKAEQE 1316
Cdd:COG5022    792 KWRLFIKLQPLLSLLgsRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIQKFGR----SLKAKKRFSLLKKE 867

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1317 ALELKMKMKEEASKRQDVaadaEKQKQNiqQELQHLKSLS---DQEIKSKNQQLEDalvSRRKIEEEIHIIRIQLEKtta 1393
Cdd:COG5022    868 TIYLQSAQRVELAERQLQ----ELKIDV--KSISSLKLVNlelESEIIELKKSLSS---DLIENLEFKTELIARLKK--- 935

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1394 HKAKSEAELQELRdraaEAEKLRKAAQD-EAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQA 1472
Cdd:COG5022    936 LLNNIDLEEGPSI----EYVKLPELNKLhEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGAL 1011

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1473 EEAERRMKQaeeekiRQIRVVEevaqksaatqlQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTARE 1552
Cdd:COG5022   1012 QESTKQLKE------LPVEVAE-----------LQSASKIISSESTELSILKPLQKLKGLLLLENNQLQARYKALKLRRE 1074

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1553 -EAEQELEIWRQKANEALRLRLQA-EEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQ 1630
Cdd:COG5022   1075 nSLLDDKQLYQLESTENLLKTINVkDLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQL 1154

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1631 IA-----QQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNStekqrkqLEDELNKVRSEMDSLLQMKI---NAE 1702
Cdd:COG5022   1155 ELdglfwEANLEALPSPPPFAALSEKRLYQSALYDEKSKLSSSEVND-------LKNELIALFSKIFSGWPRGDklkKLI 1227

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1703 KASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKqrqiaeeeaARQRSEAEKILKEKLAAI--NEATRLKTEAE 1780
Cdd:COG5022   1228 SEGWVPTEYSTSLKGFNNLNKKFDTPASMSNEKLLSLLNS---------IDNLLSSYKLEEEVLPATinSLLQYINVGLF 1298

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1781 MALKAKEAENERlkRQAEEEAYQRKLLEDQAAQHK-QDIEEKITQLQTSSDSELGRQKNIveETLKQKKVVEEEIHIIKI 1859
Cdd:COG5022   1299 NALRTKASSLRW--KSATEVNYNSEELDDWCREFEiSDVDEELEELIQAVKVLQLLKDDL--NKLDELLDACYSLNPAEI 1374

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1389908296 1860 NFHKASKEKADLESELKK--LKGIADETQKSKLKAEEEA 1896
Cdd:COG5022   1375 QNLKSRYDPADKENNLPKeiLKKIEALLIKQELQLSLEG 1413
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1387-1669 4.17e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 52.23  E-value: 4.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVaEETQRKKNAEDELKRKSDAEKeaakqKQRALDDLQ 1466
Cdd:pfam13868   60 EEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQM-DEIVERIQEEDQAEAEEKLEK-----QRQLREEID 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRvveevaqkSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKE 1546
Cdd:pfam13868  134 EFNEEQAEWKELEKEEEREEDERIL--------EYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERDE 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1547 ANTAREEAEQElEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRG------KAEEAALKQKENAEKE 1620
Cdd:pfam13868  206 LRAKLYQEEQE-RKERQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEfermlrKQAEDEEIEQEEAEKR 284

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1621 LDKQRKFAEQIAQQKLSAEQECIRLKAD-FEHAEQQRGLLDNELQRLKNE 1669
Cdd:pfam13868  285 RMKRLEHRRELEKQIEEREEQRAAEREEeLEEGERLREEEAERRERIEEE 334
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 1269-1554 4.19e-06

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 53.03  E-value: 4.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1269 RRLEDDEKASEKLKE--EERrkmaeiQAELDKQKQMAEAHAKsvAKAEQEAlelkmkmkeeASKRQDVAADAEKQKQNIQ 1346
Cdd:PRK05035   439 RAIEQEKKKAEEAKArfEAR------QARLEREKAAREARHK--KAAEARA----------AKDKDAVAAALARVKAKKA 500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1347 QELQhlKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERL 1426
Cdd:PRK05035   501 AATQ--PIVIKAGARPDNSAVIAAREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPK 578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1427 RKQVAEETQRKKNaedelKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAerRMKQAEEEKIRQIRVVEEVAQKSAATQlq 1506
Cdd:PRK05035   579 KAAVAAAIARAKA-----KKAAQQAASAEPEEQVAEVDPKKAAVAAAIA--RAKAKKAEQQANAEPEEPVDPRKAAVA-- 649

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1389908296 1507 tKAMSFSeqttkleESLKKEQGNVLKLQEEADKLKKQQKEANTAREEA 1554
Cdd:PRK05035   650 -AAIARA-------KARKAAQQQANAEPEEAEDPKKAAVAAAIARAKA 689
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1399-1559 4.81e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.08  E-value: 4.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQ-----KQRALDDLQKykmQAE 1473
Cdd:COG1579     23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQlgnvrNNKEYEALQK---EIE 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 EAERRMKQAEEEkirQIRVVEEVAQKSAATQLQTKAMSfseqttKLEESLKKEQGnvlKLQEEADKLKKQQKEANTAREE 1553
Cdd:COG1579    100 SLKRRISDLEDE---ILELMERIEELEEELAELEAELA------ELEAELEEKKA---ELDEELAELEAELEELEAEREE 167


                   ....*.
gi 1389908296 1554 AEQELE 1559
Cdd:COG1579    168 LAAKIP 173
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1474-1853 5.13e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 53.30  E-value: 5.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 EAERRMKQAEEEKIRQI---RVVEEVAQKSAATQLQTKAMSFSEQTTKLE-------ESLKKEQGNVL---KLQEEADKL 1540
Cdd:NF012221  1468 DFARRAGLSTNNGIEVLwngEVVFASSGDASAWQQKTLKLTAKAGSNRLEfkgtghnDGLGYILDNVVatsESSQQADAV 1547

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1541 KKQQKEaNTAREEAEQEleiwrQKANEALRLRLQAEEEAQ----KKSHAQEEA-EKQKLEaerdakKRGKAEEAALKQKE 1615
Cdd:NF012221  1548 SKHAKQ-DDAAQNALAD-----KERAEADRQRLEQEKQQQlaaiSGSQSQLEStDQNALE------TNGQAQRDAILEES 1615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1616 NA-EKELDKQRKFAEQIAQQKLSAEQECIRLKADFehAEqqrGLLDNelqrlknevnstekqrkqledelnkVRSEMDsl 1694
Cdd:NF012221  1616 RAvTKELTTLAQGLDALDSQATYAGESGDQWRNPF--AG---GLLDR-------------------------VQEQLD-- 1663

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1695 lqmkiNAEKASMVNTEKSKQLLESEALKMKqlaDEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATR 1774
Cdd:NF012221  1664 -----DAKKISGKQLADAKQRHVDNQQKVK---DAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQ 1735

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1775 LKTEAEMALKAKEAENERLKRQAEEEAYQrklLEDQAAQHKQDIEEKITQlQTSSDSELGRQKNIVEETLKQKKVVEEE 1853
Cdd:NF012221  1736 AESDANAAANDAQSRGEQDASAAENKANQ---AQADAKGAKQDESDKPNR-QGAAGSGLSGKAYSVEGVAEPGSHINPD 1810
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 1412-1766 5.52e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 51.84  E-value: 5.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1412 AEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRksdaEKEAAKQKQRALDDLQKykmQAEEAERRMKQAEEEKIRQIR 1491
Cdd:pfam13868   29 AEKKRIKAEEKEEERRLDEMMEEERERALEEEEEK----EEERKEERKRYRQELEE---QIEEREQKRQEEYEEKLQERE 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1492 VVEEVAQKsaatqlqtkamsfseqttkleeslkkeqgnvLKLQEEADKLKKQQKEANTARE--EAEQELEIWRQKANEAL 1569
Cdd:pfam13868  102 QMDEIVER-------------------------------IQEEDQAEAEEKLEKQRQLREEidEFNEEQAEWKELEKEEE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1570 RLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELdkqrkfAEQIAQQKLSAEQECIRLKADF 1649
Cdd:pfam13868  151 REEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAE------RDELRAKLYQEEQERKERQKER 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1650 EHAEQQRGLLDNELQRLKNEVnstEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADE 1729
Cdd:pfam13868  225 EEAEKKARQRQELQQAREEQI---ELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEE 301

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1389908296 1730 AARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKL 1766
Cdd:pfam13868  302 REEQRAAEREEELEEGERLREEEAERRERIEEERQKK 338
CH_jitterbug-like_rpt2 cd21229
second calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and ...
 121-165 6.02e-06

second calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and similar proteins; Protein jitterbug (Jbug) is an actin-meshwork organizing protein. It is required to maintain the shape and cell orientation of the Drosophila notum epithelium during flight muscle attachment to tendon cells. Jbug contains three copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409078  Cd Length: 105  Bit Score: 47.77  E-value: 6.02e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1389908296  121 RQSNQENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVS 165
Cdd:cd21229     54 PSNSLENCRRAMDLAKREFNIPMVLSPEDLSSPHLDELSGMTYLS 98
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1691-2232 6.13e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.46  E-value: 6.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1691 MDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEE-AKKQRQIAEEEAARQRSEAEKILKEKLAAI 1769
Cdd:COG4717     48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEElEELEEELEELEAELEELREELEKLEKLLQL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1770 NEATRLKTEAEMALKAKEAENERLKRQAEEeayqRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKV 1849
Cdd:COG4717    128 LPLYQELEALEAELAELPERLEELEERLEE----LRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1850 VEEEIHIIKINFHKASKEKADLESELKKLkgiadetqKSKLKAEEEAEKLKKLAAEEERrrkeaeekvkritaaeeeAAR 1929
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQL--------ENELEAAALEERLKEARLLLLI------------------AAA 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1930 QCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQkctaAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQ 2009
Cdd:COG4717    258 LLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKAS----LGKEAEELQALPALEELEEEELEELLAALGLPPD 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2010 EAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQrkeaeeeaarraAAEAAALKQKQQADAEMSKHK 2089
Cdd:COG4717    334 LSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAG------------VEDEEELRAALEQAEEYQELK 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2090 KEAEQAlqqKSQVEKELTVVKLQLDETDKQKvlLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELvklklkieEEN 2169
Cdd:COG4717    402 EELEEL---EEQLEELLGELEELLEALDEEE--LEEELEELEEELEELEEELEELREELAELEAELEQL--------EED 468

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2170 RRLMQKdkdstQKLLAEEAEKMKSLAEEAGRLSVEAE--ETARQRQIaESNLAEQRALAEKILKE 2232
Cdd:COG4717    469 GELAEL-----LQELEELKAELRELAEEWAALKLALEllEEAREEYR-EERLPPVLERASEYFSR 527
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1611-1812 6.56e-06

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 51.73  E-value: 6.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1611 LKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirlkadfehAEQQRglldneLQRLKNEVNSTEKQRKQLEDELNKVRSE 1690
Cdd:PRK09510    67 QQQQQKSAKRAEEQRKKKEQQQAEELQQKQA----------AEQER------LKQLEKERLAAQEQKKQAEEAAKQAALK 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1691 MDsllqmkiNAEKASMVNTEKSKQLLESEAlkmKQLADEAARmrsVAEEAKKQrqiAEEEAARQRSEAEKILKEKLAAIN 1770
Cdd:PRK09510   131 QK-------QAEEAAAKAAAAAKAKAEAEA---KRAAAAAKK---AAAEAKKK---AEAEAAKKAAAEAKKKAEAEAAAK 194

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1389908296 1771 EATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAA 1812
Cdd:PRK09510   195 AAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKA 236
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
2109-2315 7.17e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 52.33  E-value: 7.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2109 VKLQLDETDKQKVLLDQELQRVKGEVNDA------FKQKS-------QVEVELARVRIQMEELVKLKLKIEEENRRLmqk 2175
Cdd:COG3206    166 LELRREEARKALEFLEEQLPELRKELEEAeaaleeFRQKNglvdlseEAKLLLQQLSELESQLAEARAELAEAEARL--- 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2176 dkDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAES------------NLAEQRALAEKILKEKMQAIQEATK- 2242
Cdd:COG3206    243 --AALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELsarytpnhpdviALRAQIAALRAQLQQEAQRILASLEa 320

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2243 ----LKAEAEKLQKQKDQAQETAKRLQEdKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQT 2315
Cdd:COG3206    321 eleaLQAREASLQAQLAQLEARLAELPE-LEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVIDPAVV 396
PRK12704 PRK12704
phosphodiesterase; Provisional
 1713-1874 7.59e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 52.09  E-value: 7.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1713 KQLLESEALKMKQLAD---EAARMRsvAEEAKKQRQI-AEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEA 1788
Cdd:PRK12704    26 KKIAEAKIKEAEEEAKrilEEAKKE--AEAIKKEALLeAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1789 ENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQT--SSDSELGRQ--KNIVEETLKqKKVVEEEIHIIKiNFHKA 1864
Cdd:PRK12704   104 LLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQelERISGLTAEeaKEILLEKVE-EEARHEAAVLIK-EIEEE 181

                          170
                   ....*....|
gi 1389908296 1865 SKEKADLESE 1874
Cdd:PRK12704   182 AKEEADKKAK 191
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1499-1696 7.67e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 52.33  E-value: 7.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1499 KSAATQLQTKAMSFSEQTTKLEESLK--KEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANealRLRLQAE 1576
Cdd:COG3206    174 RKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLA---ALRAQLG 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1577 EEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAE-KELDKQRkfAEQIAQQKLSAEQECIRLKADFEHAEQQ 1655
Cdd:COG3206    251 SGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDvIALRAQI--AALRAQLQQEAQRILASLEAELEALQAR 328

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1389908296 1656 RGLLDNELQRLKNEV---NSTEKQRKQLEDELNKVRSEMDSLLQ 1696
Cdd:COG3206    329 EASLQAQLAQLEARLaelPELEAELRRLEREVEVARELYESLLQ 372
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1399-1694 8.01e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 52.65  E-value: 8.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1399 EAELQELRDRAAEAEKLRKAAQDEAERLRKQVaeetqrkknaedelkrksdaekEAAKQKQRALDDLQKYKM-------- 1470
Cdd:COG3096    835 EAELAALRQRRSELERELAQHRAQEQQLRQQL----------------------DQLKEQLQLLNKLLPQANlladetla 892

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1471 -QAEEAERRMKQAEEEK--IRQirvveevaQKSAATQLQTKAMSFsEQTTKLEESLKKEqgnVLKLQEEADKLKKQ---- 1543
Cdd:COG3096    893 dRLEELREELDAAQEAQafIQQ--------HGKALAQLEPLVAVL-QSDPEQFEQLQAD---YLQAKEQQRRLKQQifal 960

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1544 ----QKEANTAREEAEQELEIwRQKANEALRLRL-QAEEEAQKKSHAQEEAEKQKLEAerdakkrgKAEEAALKQKENAe 1618
Cdd:COG3096    961 sevvQRRPHFSYEDAVGLLGE-NSDLNEKLRARLeQAEEARREAREQLRQAQAQYSQY--------NQVLASLKSSRDA- 1030

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1619 keldKQRKFAEqiAQQKLSAeqecIRLKADFEHAEQQRGlldnELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSL 1694
Cdd:COG3096   1031 ----KQQTLQE--LEQELEE----LGVQADAEAEERARI----RRDELHEELSQNRSRRSQLEKQLTRCEAEMDSL 1092
PRK12704 PRK12704
phosphodiesterase; Provisional
 1573-1778 8.06e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 52.09  E-value: 8.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1573 LQAEEEAQK-KSHAQEEAEKQKLEAERDAKkrgkaeEAALKQKENAEKEL-DKQRKFAEQiaqqklsaEQeciRLKADFE 1650
Cdd:PRK12704    34 KEAEEEAKRiLEEAKKEAEAIKKEALLEAK------EEIHKLRNEFEKELrERRNELQKL--------EK---RLLQKEE 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1651 HAEQQRGLLDNELQRLKNEVNSTEKQRKQLEdelnKVRSEMDSLLQMKINA-EKASMVNTEKSKQLLesealkMKQLADE 1729
Cdd:PRK12704    97 NLDRKLELLEKREEELEKKEKELEQKQQELE----KKEEELEELIEEQLQElERISGLTAEEAKEIL------LEKVEEE 166

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1730 AarmrsVAEEAKKQRQIaEEEAarqRSEAEKILKEKLA-AIneaTRLKTE 1778
Cdd:PRK12704   167 A-----RHEAAVLIKEI-EEEA---KEEADKKAKEILAqAI---QRCAAD 204
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 2028-2360 8.28e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.82  E-value: 8.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2028 KAEEAEKQKKAAENEAAKQAKAQND---TEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEK 2104
Cdd:pfam07888   48 QAQEAANRQREKEKERYKRDREQWErqrRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAH 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2105 ELTVVKLQLD-ETDKQKVLL-DQELQRVKGEVNDAFKQKSQVEVElarvriqmEELVKLKLKIEEENRRLMQKDKDSTQK 2182
Cdd:pfam07888  128 EARIRELEEDiKTLTQRVLErETELERMKERAKKAGAQRKEEEAE--------RKQLQAKLQQTEEELRSLSKEFQELRN 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2183 LLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKmqaiQEATKLKAEAEKLQKQKDQAQ---- 2258
Cdd:pfam07888  200 SLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASE----RKVEGLGEELSSMAAQRDRTQaelh 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2259 --------------ETAKRLQEDKQQIQQrldkETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKF 2324
Cdd:pfam07888  276 qarlqaaqltlqlaDASLALREGRARWAQ----ERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELGRE 351

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1389908296 2325 KkqaDEVKAQLQRTEKHTTEI-----VVQKLETQRLQSTRE 2360
Cdd:pfam07888  352 K---DCNRVQLSESRRELQELkaslrVAQKEKEQLQAEKQE 389
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1747-2515 8.28e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 52.43  E-value: 8.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1747 AEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAEnerLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQ 1826
Cdd:pfam15921   72 GKEHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVID---LQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQ 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1827 TSSdSELGRQKNIVEETLKQKKV--------------VEEEIHIIKINFHKASKEKA----------------------- 1869
Cdd:pfam15921  149 NTV-HELEAAKCLKEDMLEDSNTqieqlrkmmlshegVLQEIRSILVDFEEASGKKIyehdsmstmhfrslgsaiskilr 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1870 DLESELKKLKG--IADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAAR---QCKAAQEEVERLKKK 1944
Cdd:pfam15921  228 ELDTEISYLKGriFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSarsQANSIQSQLEIIQEQ 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1945 AEDANKQKEKAEKEAEKQVvlakeaaqkctaaeqkaqdvlsknkedvlaqEKLRDEFENAKKLAQeaekakekaekeaal 2024
Cdd:pfam15921  308 ARNQNSMYMRQLSDLESTV-------------------------------SQLRSELREAKRMYE--------------- 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2025 lrQKAEEAEKQKKAAENEAAkQAKAQNDTEKQRKEAEEeaarraaaeaaalKQKQQADAEMSKHKKEAEQALQQKSQVEK 2104
Cdd:pfam15921  342 --DKIEELEKQLVLANSELT-EARTERDQFSQESGNLD-------------DQLQKLLADLHKREKELSLEKEQNKRLWD 405

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2105 ELTVVKLQLDETDKQKVLLDQELQRVKGEVNdAFKQKSQVEVELARVRIQ-----MEELVKLKLKIEEENRRLMQKDKDS 2179
Cdd:pfam15921  406 RDTGNSITIDHLRRELDDRNMEVQRLEALLK-AMKSECQGQMERQMAAIQgknesLEKVSSLTAQLESTKEMLRKVVEEL 484

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2180 T-QKLLAEEAEKMKSlaeeagRLSVEAEETARQRQIAESNLAEQRALAEkiLKekmqaIQEATKLKAEAEKLQKQkdQAQ 2258
Cdd:pfam15921  485 TaKKMTLESSERTVS------DLTASLQEKERAIEATNAEITKLRSRVD--LK-----LQELQHLKNEGDHLRNV--QTE 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2259 ETAKRLQ-EDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLaqtkaedEAKKFKKQADEVKAQLQR 2337
Cdd:pfam15921  550 CEALKLQmAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRL-------ELQEFKILKDKKDAKIRE 622

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2338 TEKHTTEIVVQKLE-----TQRLQSTREA--------DDLKSAIADLEEERKKLKKEAEELQRKSKEM---ANAQQEQIE 2401
Cdd:pfam15921  623 LEARVSDLELEKVKlvnagSERLRAVKDIkqerdqllNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMettTNKLKMQLK 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2402 QQKAELQQSFLTEKGL----------LLKREKEVEGEKKRFEKqLEDEMKKAKALKDEQERQRKLMEEERKKL-QAIMDE 2470
Cdd:pfam15921  703 SAQSELEQTRNTLKSMegsdghamkvAMGMQKQITAKRGQIDA-LQSKIQFLEEAMTNANKEKHFLKEEKNKLsQELSTV 781

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2471 AVRKQKEA---------EEEMKNKQREMDV-LDKKRLE----QEKQLAEENKKLREQLQ 2515
Cdd:pfam15921  782 ATEKNKMAgelevlrsqERRLKEKVANMEVaLDKASLQfaecQDIIQRQEQESVRLKLQ 840
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2081-2482 8.90e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 52.35  E-value: 8.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2081 ADAEMSKHKKEAEQAlqQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVK 2160
Cdd:PRK02224   307 ADAEAVEARREELED--RDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRRE 384

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2161 LKLKIEEENRRLMQKDKDSTQKLlAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEK------------ 2228
Cdd:PRK02224   385 EIEELEEEIEELRERFGDAPVDL-GNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAgkcpecgqpveg 463

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2229 -----ILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQqRLDKETEGFQKSLEAERKRQLEASAEAEKL 2303
Cdd:PRK02224   464 sphveTIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIE-RLEERREDLEELIAERRETIEEKRERAEEL 542

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2304 KLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIvvqKLETQRLQSTREADDLKSAIADLEEERKKLKKEAE 2383
Cdd:PRK02224   543 RERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAEL---KERIESLERIRTLLAAIADAEDEIERLREKREALA 619

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2384 ELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKE----VEGEKKRFEKQLEDEMKKAKALKDEQERQRKLmEE 2459
Cdd:PRK02224   620 ELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEyleqVEEKLDELREERDDLQAEIGAVENELEELEEL-RE 698

                          410       420
                   ....*....|....*....|....*
gi 1389908296 2460 ERKKLQAIMD--EAVRKQKEAEEEM 2482
Cdd:PRK02224   699 RREALENRVEalEALYDEAEELESM 723
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2193-2407 9.37e-06

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 51.35  E-value: 9.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2193 SLAEEAGRLSvEAEETARQRQIAESNLAEQRA--LAEKILKEKmqaiQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQ 2270
Cdd:PRK09510    59 AVVEQYNRQQ-QQQKSAKRAEEQRKKKEQQQAeeLQQKQAAEQ----ERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQ 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2271 IQQRLDKETEGFQKSLEAERKRQLEASAEAEklklrvkelSLAQTKAEDEAKKfkKQADEVKAQLQRTEKHTTEIVVQKL 2350
Cdd:PRK09510   134 AEEAAAKAAAAAKAKAEAEAKRAAAAAKKAA---------AEAKKKAEAEAAK--KAAAEAKKKAEAEAAAKAAAEAKKK 202

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2351 ETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAEL 2407
Cdd:PRK09510   203 AEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEV 259
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 110-167 9.97e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 46.93  E-value: 9.97e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296   110 VPALIDMNQVYRQSNQ----ENLEQAFSVAERELGVTKLLDPEDVDVPHPDEKSIITYVSSL 167
Cdd:smart00033   40 SPGLVDKKKVAASLSRfkkiENINLALSFAEKLGGKVVLFEPEDLVEGPKLILGVIWTLISL 101
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1450-1705 1.03e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1450 AEKEAAKQKQRALDDLQKykmQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQlqtkamsfsEQTTKLEESLKKEQGN 1529
Cdd:COG4942     17 AQADAAAEAEAELEQLQQ---EIAELEKELAALKKEEKALLKQLAALERRIAALA---------RRIRALEQELAALEAE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1530 VLKLQEEADKLKKQQKEanTAREEAEQELEIWRQKANEALRLRLQAEEEAQkkshaqeeaekqkleAERDA---KKRGKA 1606
Cdd:COG4942     85 LAELEKEIAELRAELEA--QKEELAELLRALYRLGRQPPLALLLSPEDFLD---------------AVRRLqylKYLAPA 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1607 EEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLdneLQRLKNEVNSTEKQRKQLEDELNK 1686
Cdd:COG4942    148 RREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKL---LARLEKELAELAAELAELQQEAEE 224

                          250
                   ....*....|....*....
gi 1389908296 1687 VRSEMDSLLQMKINAEKAS 1705
Cdd:COG4942    225 LEALIARLEAEAAAAAERT 243
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1788-1900 1.05e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 51.75  E-value: 1.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1788 AENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQ-KKVVEEEIHIIKI---NFHK 1863
Cdd:PRK00409   523 ASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKEaKKEADEIIKELRQlqkGGYA 602

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1389908296 1864 ASKEKaDLESELKKLKGIADETQKSKLKAEEEAEKLK 1900
Cdd:PRK00409   603 SVKAH-ELIEARKRLNKANEKKEKKKKKQKEKQEELK 638
PLEC smart00250
Plectin repeat;
2689-2725 1.08e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 1.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2689 RLLSAERAATGFKDPYTGAKISLFEAMNKGLIEKEQA 2725
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3015-3051 1.12e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.78  E-value: 1.12e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3015 RLLSAEKAVSGYHDPYTGKKVSLFEALKLGLIKKDHG 3051
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2174-2344 1.17e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 50.96  E-value: 1.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2174 QKDKDSTQKLLAE--EAEKMKSLAEEAGRL-SVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQ-EATKLKAEAEK 2249
Cdd:PRK09510    74 AKRAEEQRKKKEQqqAEELQQKQAAEQERLkQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAaAAAKAKAEAEA 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2250 lqkqkDQAQETAKRLQEDKQQiqqrldKETEGFQKSLEAERKRQLEASAEAeklklrvkelslaqtKAEDEAKKFKKQAD 2329
Cdd:PRK09510   154 -----KRAAAAAKKAAAEAKK------KAEAEAAKKAAAEAKKKAEAEAAA---------------KAAAEAKKKAEAEA 207

                          170
                   ....*....|....*
gi 1389908296 2330 EVKAQLQRTEKHTTE 2344
Cdd:PRK09510   208 KKKAAAEAKKKAAAE 222
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 3847-3885 1.19e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 45.01  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1389908296 3847 YLEGSSCIAGVYVESSKDRLSIYQAMKKNMIRPGTAFEL 3885
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 1437-1696 1.22e-05

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 49.99  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1437 KKNAEDELKRKsdAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEkIRQIRvvEEVAQKSAATQLQTKAMSFSEQT 1516
Cdd:pfam12795    6 EKAKLDEAAKK--KLLQDLQQALSLLDKIDASKQRAAAYQKALDDAPAE-LRELR--QELAALQAKAEAAPKEILASLSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1517 TKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEaLRLRLQAEEEAQKkshAQEEAEKQKLEA 1596
Cdd:pfam12795   81 EELEQRLLQTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQRLQQ-IRNRLNGPAPPGE---PLSEAQRWALQA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1597 ERdakkrgkaeeAALKQkenaekELDKQRKfaeqiAQQKLSAEQECIRLKADFEHAEQQRglLDNELQRLKNEVNS---- 1672
Cdd:pfam12795  157 EL----------AALKA------QIDMLEQ-----ELLSNNNRQDLLKARRDLLTLRIQR--LEQQLQALQELLNEkrlq 213

                          250       260
                   ....*....|....*....|....*
gi 1389908296 1673 -TEKQRKQLEDELNKVRSEMDSLLQ 1696
Cdd:pfam12795  214 eAEQAVAQTEQLAEEAAGDHPLVQQ 238
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1354-1526 1.23e-05

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 51.16  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1354 SLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAelQELRDRAAEAEKLRKAAQDEAERLRKQVAEE 1433
Cdd:pfam05262  176 SISDKKVVEALREDNEKGVNFRRDMTDLKERESQEDAKRAQQLKEEL--DKKQIDADKAQQKADFAQDNADKQRDEVRQK 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1434 TQRKKNAEDELKRKSDAEKE--AAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAAtQLQTKAMS 1511
Cdd:pfam05262  254 QQEAKNLPKPADTSSPKEDKqvAENQKREIEKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKEL-EAQKKREP 332

                          170
                   ....*....|....*
gi 1389908296 1512 FSEQTTKLEESLKKE 1526
Cdd:pfam05262  333 VAEDLQKTKPQVEAQ 347
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1022-1582 1.40e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.60  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1022 IRNTADAEETLKNYEARL----RDVSKVPSEQKEVEKHRSQMKSMRSEAEADQVMFDRLQDDLRKATTVHDKMTRIHSER 1097
Cdd:PRK03918   185 IKRTENIEELIKEKEKELeevlREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIREL 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1098 DADLEHYRQLVNGLLERWQAVfAQIELRLRELDLLGRHMNSYRDSYEWLIRWLTEARQRQEKIQAVpISDSRALREQLTD 1177
Cdd:PRK03918   265 EERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER-IKELEEKEERLEE 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1178 EKKLLGEIEKNKDKIDDchknakayidSVKDYEfqilTYKALQDPIASpLKKPKMECASDDIIQEYVNLRTRYSELMTLT 1257
Cdd:PRK03918   343 LKKKLKELEKRLEELEE----------RHELYE----EAKAKKEELER-LKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1258 NQYIKFIIDAQRRLEDDEKASEKLK---------------EEERRKMAEIQAELDK-QKQMAEAHAK-SVAKAEQEALEL 1320
Cdd:PRK03918   408 SKITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteEHRKELLEEYTAELKRiEKELKEIEEKeRKLRKELRELEK 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1321 KMKMKEEASKRQDVAadaeKQKQNIQQELqhlKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEA 1400
Cdd:PRK03918   488 VLKKESELIKLKELA----EQLKELEEKL---KKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1401 ---ELQELRDRAAEAEK-LRKAAQDEAERLRKQVAE------ETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKM 1470
Cdd:PRK03918   561 lekKLDELEEELAELLKeLEELGFESVEELEERLKElepfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1471 QAEEAERRMKQAE----EEKIRQIRvveevaqkSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKE 1546
Cdd:PRK03918   641 RLEELRKELEELEkkysEEEYEELR--------EEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKE 712

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1389908296 1547 ANTArEEAEQELEIWRQKaneALRLRLQAEEEAQKK 1582
Cdd:PRK03918   713 LEKL-EKALERVEELREK---VKKYKALLKERALSK 744
CH_SMTNB cd21259
calponin homology (CH) domain found in smoothelin-B and similar proteins; Smoothelins are ...
 111-168 1.49e-05

calponin homology (CH) domain found in smoothelin-B and similar proteins; Smoothelins are actin-binding cytoskeletal proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. The human SMTN gene encodes smoothelin-A and smoothelin-B. This model corresponds to the single CH domain of smoothelin-B. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409108  Cd Length: 112  Bit Score: 46.91  E-value: 1.49e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21259     44 PEAFDYSQLSPQNRRHNFEVAFSSAEKHADCPQLLDVEDmVRMREPDWKCVYTYIQEFY 102
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1864-2524 1.53e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 51.38  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1864 ASKEKADLESELKKLKG--IADETQKSKLKaEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERL 1941
Cdd:pfam12128  249 EFNTLESAELRLSHLHFgyKSDETLIASRQ-EERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAL 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1942 ---KKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAA-EQKAQDVLSKNKedvlAQEKLRDEfENAKKLAQEAEKAKEK 2017
Cdd:pfam12128  328 edqHGAFLDADIETAAADQEQLPSWQSELENLEERLKAlTGKHQDVTAKYN----RRRSKIKE-QNNRDIAGIKDKLAKI 402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2018 AekeaallrqkaEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALK--------------QKQQADA 2083
Cdd:pfam12128  403 R-----------EARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKlrlnqatatpelllQLENFDE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2084 EMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAfkqksqvevelarvriqMEELVKLKL 2163
Cdd:pfam12128  472 RIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDEL-----------------ELQLFPQAG 534

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2164 KIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETA-----RQRQI-------AESNLAEQRALAEKIL- 2230
Cdd:pfam12128  535 TLLHFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELNLygvklDLKRIdvpewaaSEEELRERLDKAEEALq 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2231 --KEKMQAIQEA-TKLKAEAEKLQKQK-------DQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEaERKRQLEasAEA 2300
Cdd:pfam12128  615 saREKQAAAEEQlVQANGELEKASREEtfartalKNARLDLRRLFDEKQSEKDKKNKALAERKDSAN-ERLNSLE--AQL 691

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2301 EKLKLRVKELSLAQTKAEDEAKKFKKQADEVkaqLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKK 2380
Cdd:pfam12128  692 KQLDKKHQAWLEEQKEQKREARTEKQAYWQV---VEGALDAQLALLKAAIAARRSGAKAELKALETWYKRDLASLGVDPD 768

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2381 EAEELQRKSKEMaNAQQEQIEQQKAE-------LQQSFLTEKGLLLKREKEVEGEKKRFEKQLedemkkaKALKDEQERQ 2453
Cdd:pfam12128  769 VIAKLKREIRTL-ERKIERIAVRRQEvlryfdwYQETWLQRRPRLATQLSNIERAISELQQQL-------ARLIADTKLR 840

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2454 RKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQR--------EMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTV 2524
Cdd:pfam12128  841 RAKLEMERKASEKQQVRLSENLRGLRCEMSKLATlkedanseQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKNV 919
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 2208-2514 1.57e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 50.30  E-value: 1.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2208 TARQRQIAEsnlAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLE 2287
Cdd:pfam13868   22 KERDAQIAE---KKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQ 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2288 AERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVvqkLETQRLQSTREADdlksa 2367
Cdd:pfam13868   99 EREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERI---LEYLKEKAEREEE----- 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2368 iadleeeRKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQsfltekgLLLKREKEvEGEKKRFEKQLEDEMKKAKALK 2447
Cdd:pfam13868  171 -------REAEREEIEEEKEREIARLRAQQEKAQDEKAERDE-------LRAKLYQE-EQERKERQKEREEAEKKARQRQ 235

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2448 DEQERQRKLMEEERKKLQaimdEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQL 2514
Cdd:pfam13868  236 ELQQAREEQIELKERRLA----EEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQ 298
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1396-1486 1.61e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 51.37  E-value: 1.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1396 AKSEAELQELRDRAAEAEKLRKaaqdEAERLRKQVAEETQRKKNAEDELKRKSDAE--------KEAAKQKQRALDDLQK 1467
Cdd:PRK00409   523 ASLEELERELEQKAEEAEALLK----EAEKLKEELEEKKEKLQEEEDKLLEEAEKEaqqaikeaKKEADEIIKELRQLQK 598

                           90       100
                   ....*....|....*....|....*
gi 1389908296 1468 YKM------QAEEAERRMKQAEEEK 1486
Cdd:PRK00409   599 GGYasvkahELIEARKRLNKANEKK 623
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1022-1846 1.70e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 51.59  E-value: 1.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1022 IRNTADaEETLKNYEARLRDVSKVPSEQKEVEKHRSQMKSMRSEAEADQVMFDRLQDDLR-KATTVHDKMT----RIHSE 1096
Cdd:TIGR01612  801 IDNIKD-EDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCKeKIDSEHEQFAeltnKIKAE 879

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1097 -RDADLEHYRQLVNGllerwqaVFAQIELRLRELDLLGRHMNSYR--DSYEWLIRWLTEARQRQEKIQAVpisdsraLRE 1173
Cdd:TIGR01612  880 iSDDKLNDYEKKFND-------SKSLINEINKSIEEEYQNINTLKkvDEYIKICENTKESIEKFHNKQNI-------LKE 945

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1174 QLTDEKKLLGE---IEKN-KDKIDDCHKNAKAYID------SVKDYEFQILTYKALQDPIASPLKKPK----------ME 1233
Cdd:TIGR01612  946 ILNKNIDTIKEsnlIEKSyKDKFDNTLIDKINELDkafkdaSLNDYEAKNNELIKYFNDLKANLGKNKenmlyhqfdeKE 1025

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1234 CASDDIIQEYVNLRTRYSELMTLTNQYIKFIID--------------------AQRRLEDDEKASEKLK--------EEE 1285
Cdd:TIGR01612 1026 KATNDIEQKIEDANKNIPNIEIAIHTSIYNIIDeiekeigkniellnkeileeAEINITNFNEIKEKLKhynfddfgKEE 1105

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1286 RRKMA----EIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADA---------EKQKQNIQQELQHL 1352
Cdd:TIGR01612 1106 NIKYAdeinKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDVADKAisnddpeeiEKKIENIVTKIDKK 1185

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1353 KSLSDQ---------EIKSKNQQLEDalVSRRKIEEEIHIIRIQLEKTTAHKAKSE----------AELQELRDRAAEAE 1413
Cdd:TIGR01612 1186 KNIYDEikkllneiaEIEKDKTSLEE--VKGINLSYGKNLGKLFLEKIDEEKKKSEhmikameayiEDLDEIKEKSPEIE 1263

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1414 KLRKAAQDEAERLR-------KQVAEETQRKKNAED--ELKRKSDAEKEAAKQKQRALD---DLQKYKMQAEEAERRMKQ 1481
Cdd:TIGR01612 1264 NEMGIEMDIKAEMEtfnishdDDKDHHIISKKHDENisDIREKSLKIIEDFSEESDINDikkELQKNLLDAQKHNSDINL 1343

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1482 AEEE--------KIRQIR-VVEEVaqKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVlKLQEEADKLK----------- 1541
Cdd:TIGR01612 1344 YLNEianiynilKLNKIKkIIDEV--KEYTKEIEENNKNIKDELDKSEKLIKKIKDDI-NLEECKSKIEstlddkdidec 1420

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1542 -KQQKEANTAREEAEQELEIWRQKA---NEALRLRLQAEEEAQKKSHAQEEAEK-----------QKLEAERDAKKRGKA 1606
Cdd:TIGR01612 1421 iKKIKELKNHILSEESNIDTYFKNAdenNENVLLLFKNIEMADNKSQHILKIKKdnatndhdfniNELKEHIDKSKGCKD 1500

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1607 EEAALKQKENAEKELDKQRKFAEQIAQQKLSAeqecIRLKADFEHAEQQRGLLDNELQRLKN----EVNSTEKQRKQLED 1682
Cdd:TIGR01612 1501 EADKNAKAIEKNKELFEQYKKDVTELLNKYSA----LAIKNKFAKTKKDSEIIIKEIKDAHKkfilEAEKSEQKIKEIKK 1576

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1683 ElnKVRSEMDSllqMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKqrQIAEEEAARQRSEaekiL 1762
Cdd:TIGR01612 1577 E--KFRIEDDA---AKNDKSNKAAIDIQLSLENFENKFLKISDIKKKINDCLKETESIEK--KISSFSIDSQDTE----L 1645

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1763 KEKLAAINEatrLKTEAEmALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIE----EKITQLQTSSDSELGRQKN 1838
Cdd:TIGR01612 1646 KENGDNLNS---LQEFLE-SLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNYEigiiEKIKEIAIANKEEIESIKE 1721


                   ....*...
gi 1389908296 1839 IVEETLKQ 1846
Cdd:TIGR01612 1722 LIEPTIEN 1729
PRK11637 PRK11637
AmiB activator; Provisional
 1329-1582 1.81e-05

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 50.46  E-value: 1.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1329 SKRQDVaadAEKQKqNIQQELQHLKSLSDQeIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKseaelqeLRDR 1408
Cdd:PRK11637    51 SIQQDI---AAKEK-SVRQQQQQRASLLAQ-LKKQEEAISQASRKLRETQNTLNQLNKQIDELNASIAK-------LEQQ 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1409 AAEAEKLRKAAQDEAERLRKQVA-------EETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEaerrmKQ 1481
Cdd:PRK11637   119 QAAQERLLAAQLDAAFRQGEHTGlqlilsgEESQRGERILAYFGYLNQARQETIAELKQTREELAAQKAELEE-----KQ 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1482 AEEEKIrqirvveeVAQKSAATQLQTKAMSFSEQT-TKLEESLKKEQGNVLKL-QEEA---DKLKKQQKEantAREEAEQ 1556
Cdd:PRK11637   194 SQQKTL--------LYEQQAQQQKLEQARNERKKTlTGLESSLQKDQQQLSELrANESrlrDSIARAERE---AKARAER 262

                          250       260
                   ....*....|....*....|....*.
gi 1389908296 1557 EleiwrqkANEALRLRlQAEEEAQKK 1582
Cdd:PRK11637   263 E-------AREAARVR-DKQKQAKRK 280
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 2123-2477 2.11e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 51.21  E-value: 2.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2123 LDQELQRVKGEVNDAfkQKSQVEVELARVRIQMEElvklklKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEagRLS 2202
Cdd:PRK10929    28 ITQELEQAKAAKTPA--QAEIVEALQSALNWLEER------KGSLERAKQYQQVIDNFPKLSAELRQQLNNERDE--PRS 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2203 VEAEETARqrqiaesnlaeqrALAEKILKEKMQAIQEATKLKAEAEKLQKQKD------QAQETAKRLQEDkqqIQQRLd 2276
Cdd:PRK10929    98 VPPNMSTD-------------ALEQEILQVSSQLLEKSRQAQQEQDRAREISDslsqlpQQQTEARRQLNE---IERRL- 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2277 ketEGFQKSLEAERKRQLEA-SAEAEKLKLRVKELSLAQTKAED-------EAKKFKKQADEVKAQLQRTEKHTTEIVVQ 2348
Cdd:PRK10929   161 ---QTLGTPNTPLAQAQLTAlQAESAALKALVDELELAQLSANNrqelarlRSELAKKRSQQLDAYLQALRNQLNSQRQR 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2349 KLEtQRLQSTR----EADDLKSAIADlEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQ--SFLTEKGLLLKrE 2422
Cdd:PRK10929   238 EAE-RALESTEllaeQSGDLPKSIVA-QFKINRELSQALNQQAQRMDLIASQQRQAASQTLQVRQalNTLREQSQWLG-V 314

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 2423 KEVEGEKKRFE----------KQLEDEMKK--AKALK--DEQERQRKLMEEERKKLQA-------IMDEAVRKQKE 2477
Cdd:PRK10929   315 SNALGEALRAQvarlpempkpQQLDTEMAQlrVQRLRyeDLLNKQPQLRQIRQADGQPltaeqnrILDAQLRTQRE 390
PLEC smart00250
Plectin repeat;
3845-3882 2.11e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  3845 KKYLEGSSCIAGVYVESSKDRLSIYQAMKKNMIRPGTA 3882
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Granin pfam01271
Granin (chromogranin or secretogranin);
1273-1770 2.12e-05

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 50.80  E-value: 2.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1273 DDEKASEKLKEEERRKMAEIQAELDKQKQmAEAHAKSVAKAE---QEALELKMKMKEEASKRQDVAADAEKQKQNIQQEL 1349
Cdd:pfam01271   69 EASHLSSRSRDGLSDEDMQIITEALRQAE-NEPGGHSRENQPyalQVEKEFKTDHSDDYETQQWEEEKLKHMRFPLRYEE 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1350 QHLKSLSDQEIKSKNQQLedalvsrrkieeeIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLrkaAQDEAERLRKQ 1429
Cdd:pfam01271  148 NSEEKHSEREGELSEVFE-------------NPRSQATLKKVFEEVSRLDTPSKQKREKSDEREKS---SQESGEDTYRQ 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1430 --VAEETQRKKNAEDElkrksDAEKEaakqkqralddlqkyKMQAEEAERRMKQaEEEKIRQIrvvEEVAQKSAATQLQT 1507
Cdd:pfam01271  212 enIPQEDQVGPEDQEP-----SEEGE---------------EDATQEEVKRSRP-RTHHGRSL---PDESSRGGQLGLEE 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1508 KAMSFSEQTTKLEESLKKEQGNVLKLqEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRL--RLQAEEEAQKK--- 1582
Cdd:pfam01271  268 EASEEEEEYGEESRGLSAVQTYLLRL-VNARGRGRSEKRAERERSEESEEEELKRASPYEELEItaNLQIPPSEEERmlk 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1583 ----SHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDK--QRKFAEQIAQQ-------KLSAEQECIRLKADF 1649
Cdd:pfam01271  347 kagrSPRGRVDEAGALEALEALEEKRKLDLDHSRVFESSEDGAPRapQGAWVEALRNYlsygeegMEGKWNQQGPYFPNE 426

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1650 EHAEQQRGLLDNELQRLKNE-------VNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSkqlLESEALK 1722
Cdd:pfam01271  427 ENREEARFRLPQYLGELSNPwedpkqwKPSDFERKELTADKFLEGEEENEYTLSMKNSFPEYNYDGYEKR---VPSPGLD 503

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 1723 MKQLADEAAR---------------MRSVAEEAKKQRQIA--EEEAARQRSEAEKILKEKLAAIN 1770
Cdd:pfam01271  504 LKRQYDPVARedqllhyrkkssefpDFYDSEEKKEPPVGAekEEDSANRQTRDEDKELENLAAMD 568
PRK11281 PRK11281
mechanosensitive channel MscK;
1290-1702 2.19e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 51.07  E-value: 2.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1290 AEIQAELD---KQKQmAEAHAKSVAKAEQEALEL---KMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSK 1363
Cdd:PRK11281    39 ADVQAQLDalnKQKL-LEAEDKLVQQDLEQTLALldkIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRET 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1364 -----NQQLEDALVSRRkieeeihiiriqlekttahkakseAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKK 1438
Cdd:PRK11281   118 lstlsLRQLESRLAQTL------------------------DQLQNAQNDLAEYNSQLVSLQTQPERAQAALYANSQRLQ 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1439 NAEDELKrKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRM-------------KQAEEEKIRQIRVVEEVAqksaatQL 1505
Cdd:PRK11281   174 QIRNLLK-GGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKslegntqlqdllqKQRDYLTARIQRLEHQLQ------LL 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1506 QT----KAMSFSEQTTKLEESLKKEQgnvlklQEEADKLKKQQKEANTareEAEQELEIWRQKANEALRLRLQAeeeaqk 1581
Cdd:PRK11281   247 QEainsKRLTLSEKTVQEAQSQDEAA------RIQANPLVAQELEINL---QLSQRLLKATEKLNTLTQQNLRV------ 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1582 kshaqeeaeKQKLE----AERDAKKRGKAEEAAL-------KQKENAEKeLDKQRKFAEQIAQqklsaeqecIRLKAdFE 1650
Cdd:PRK11281   312 ---------KNWLDrltqSERNIKEQISVLKGSLllsrilyQQQQALPS-ADLIEGLADRIAD---------LRLEQ-FE 371

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1651 hAEQQRGLL-------DNELQRLKNEVNSTEKQ--------RKQLEDELNKvrsEMDSLLQMKINAE 1702
Cdd:PRK11281   372 -INQQRDALfqpdayiDKLEAGHKSEVTDEVRDallqlldeRRELLDQLNK---QLNNQLNLAINLQ 434
PLEC smart00250
Plectin repeat;
3385-3420 2.35e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.35e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1389908296  3385 LLEAQLATGGIIDPASSHRVPTDVAIQRGYFSKQMA 3420
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2076-2531 2.38e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 50.94  E-value: 2.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEaEQALQQKSQVEKELTVVKLQLDETDkqkvLLDQELQRVKGEvndafKQKSQVEVELARVRIQM 2155
Cdd:pfam01576   99 KKMQQHIQDLEEQLDE-EEAARQKLQLEKVTTEAKIKKLEED----ILLLEDQNSKLS-----KERKLLEERISEFTSNL 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2156 EElvklklkiEEENRRLMQKDKDSTQKLLAEEAEKMKSlaEEAGRLSVEAEETARQRQIAE--SNLAEQRALAEKILKEK 2233
Cdd:pfam01576  169 AE--------EEEKAKSLSKLKNKHEAMISDLEERLKK--EEKGRQELEKAKRKLEGESTDlqEQIAELQAQIAELRAQL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2234 MQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQrlDKETEGFQKSLEAERKRQLEASAEAEKLKL-------- 2305
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQE--DLESERAARNKAEKQRRDLGEELEALKTELedtldtta 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2306 --------RVKELSLAQTKAEDEAKKFKKQADEV-KAQLQRTEKHTTEIVVQKLETQRLQSTREAddLKSAIADLEEERK 2376
Cdd:pfam01576  317 aqqelrskREQEVTELKKALEEETRSHEAQLQEMrQKHTQALEELTEQLEQAKRNKANLEKAKQA--LESENAELQAELR 394

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2377 KLKKEAEELQRKSKEMANAQQE-QIEQQKAELQQSFLTEKGLLLKREKE-VEGEKKRFEKQLEDEMKKAKALKDE-QERQ 2453
Cdd:pfam01576  395 TLQQAKQDSEHKRKKLEGQLQElQARLSESERQRAELAEKLSKLQSELEsVSSLLNEAEGKNIKLSKDVSSLESQlQDTQ 474

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2454 RKLMEEERKKLQAimdeaVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQ 2531
Cdd:pfam01576  475 ELLQEETRQKLNL-----STRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGK 547
PLEC smart00250
Plectin repeat;
3346-3382 2.62e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.01  E-value: 2.62e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3346 KLLSAEKAITGYRDPYTGNKISLFQAMKKELVLREHA 3382
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1534-1725 2.69e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.84  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1534 QEEADKLKKQQKEANTAREEAEQELEiwRQKANEA----LRLRLQAEEEAQKKSHAQEEAEKQKLEAERdAKKRGKAEEA 1609
Cdd:TIGR02794   57 QQKKPAAKKEQERQKKLEQQAEEAEK--QRAAEQArqkeLEQRAAAEKAAKQAEQAAKQAEEKQKQAEE-AKAKQAAEAK 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1610 ALKQKENAEKELDKQRKFAEQIAQQKLSAE----QECIRLKADFEHAEQQrgllDNELQRLKNEVNSTEKQRKQLEDELN 1685
Cdd:TIGR02794  134 AKAEAEAERKAKEEAAKQAEEEAKAKAAAEakkkAEEAKKKAEAEAKAKA----EAEAKAKAEEAKAKAEAAKAKAAAEA 209

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1389908296 1686 KVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQ 1725
Cdd:TIGR02794  210 AAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQ 249
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1580-1789 2.72e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 49.80  E-value: 2.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1580 QKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirlKADFEHAEQQRgll 1659
Cdd:PRK09510    70 QQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQ----KQAEEAAAKAA--- 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1660 dnELQRLKnevnsTEKQRKQLEDELNKVRSEMDsllqmKINAEKASMVNTEKSKQLLESEAlkmKQLADEAARMRSVAEE 1739
Cdd:PRK09510   143 --AAAKAK-----AEAEAKRAAAAAKKAAAEAK-----KKAEAEAAKKAAAEAKKKAEAEA---AAKAAAEAKKKAEAEA 207

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1740 AKKQRQIAEEEAARQ-RSEAEKILKEKLAAINEATRLKTEAEMALKAKEAE 1789
Cdd:PRK09510   208 KKKAAAEAKKKAAAEaKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1387-1616 2.73e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 50.99  E-value: 2.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRA-AEAEKLRkaAQDEAERLRKQVAEeTQRKKNAEDE--LKRKSDAEKEAAKQKQRA-- 1461
Cdd:NF012221  1543 QADAVSKHAKQDDAAQNALADKErAEADRQR--LEQEKQQQLAAISG-SQSQLESTDQnaLETNGQAQRDAILEESRAvt 1619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1462 ---------LDDLQKYKMQAEEAERRMKQAEEEKIRQiRVVEEV--AQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNV 1530
Cdd:NF012221  1620 kelttlaqgLDALDSQATYAGESGDQWRNPFAGGLLD-RVQEQLddAKKISGKQLADAKQRHVDNQQKVKDAVAKSEAGV 1698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1531 LKLQEeadklKKQQKEANTAREEAEQEleiwrQKANEALRlrlqAEEEAQK-KSHAQEEAEKQKLEAERDAKKRG----- 1604
Cdd:NF012221  1699 AQGEQ-----NQANAEQDIDDAKADAE-----KRKDDALA----KQNEAQQaESDANAAANDAQSRGEQDASAAEnkanq 1764

                          250
                   ....*....|...
gi 1389908296 1605 -KAEEAALKQKEN 1616
Cdd:NF012221  1765 aQADAKGAKQDES 1777
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 2192-2406 2.77e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 49.84  E-value: 2.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2192 KSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKilkekmQAIQEATKLKAEAEKLQKQKD--QAQETAKRLQEDKQ 2269
Cdd:TIGR02794   46 GAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEK------QRAAEQARQKELEQRAAAEKAakQAEQAAKQAEEKQK 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2270 QIQQRLDKETEGFQKSLEAERKRQLEA----SAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTE-KHTTE 2344
Cdd:TIGR02794  120 QAEEAKAKQAAEAKAKAEAEAERKAKEeaakQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEaKAKAE 199

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2345 IVVQKLETqrlQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAE 2406
Cdd:TIGR02794  200 AAKAKAAA---EAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAG 258
PLEC smart00250
Plectin repeat;
4055-4083 2.87e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.62  E-value: 2.87e-05
                            10        20
                    ....*....|....*....|....*....
gi 1389908296  4055 VRKRRVVIVDPESGKEMSVYEAYQKGLID 4083
Cdd:smart00250    6 AQSAIGGIIDPETGQKLSVEEALRRGLID 34
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2239-2496 2.90e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 2.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2239 EATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQ--QRLDKETEGFQKSL-EAERKRQLEASAEAEKLKLRVKELSLAQT 2315
Cdd:COG4913    219 EEPDTFEAADALVEHFDDLERAHEALEDAREQIEllEPIRELAERYAAAReRLAELEYLRAALRLWFAQRRLELLEAELE 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2316 KAEDEAKKFKKQADEVKAQLQRTEKHtteivVQKLETQRLQS-TREADDLKSAIADleeerkklkkeaeelqrkskemAN 2394
Cdd:COG4913    299 ELRAELARLEAELERLEARLDALREE-----LDELEAQIRGNgGDRLEQLEREIER----------------------LE 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2395 AQQEQIEQQKAELQQsFLTEKGLllkrekEVEGEKKRFEKQLEdemkKAKALKDEQERQRKLMEEERkklqaimDEAVRK 2474
Cdd:COG4913    352 RELEERERRRARLEA-LLAALGL------PLPASAEEFAALRA----EAAALLEALEEELEALEEAL-------AEAEAA 413

                          250       260
                   ....*....|....*....|..
gi 1389908296 2475 QKEAEEEMKNKQREMDVLDKKR 2496
Cdd:COG4913    414 LRDLRRELRELEAEIASLERRK 435
CH_MICAL2_3-like cd21195
calponin homology (CH) domain found in molecule interacting with CasL protein 2 (MICAL-2), ...
 111-170 3.26e-05

calponin homology (CH) domain found in molecule interacting with CasL protein 2 (MICAL-2), MICAL-3, and similar proteins; Molecule interacting with CasL protein (MICAL) is a large, multidomain, cytosolic protein with a single LIM domain, a calponin homology (CH) domain and a flavoprotein monooxygenase (MO) domain. In Drosophila, MICAL is expressed in axons, interacts with the neuronal A (PlexA) receptor and is required for Semaphorin 1a (Sema-1a)-PlexA-mediated repulsive axon guidance. The LIM and CH domains mediate interactions with the cytoskeleton, cytoskeletal adaptor proteins, and other signaling proteins. The flavoprotein MO is required for semaphorin-plexin repulsive axon guidance during axonal pathfinding in the Drosophila neuromuscular system. In addition, MICAL functions to interact with Rab13 and Rab8 to coordinate the assembly of tight junctions and adherens junctions in epithelial cells. Thus, MICAL is also called junctional Rab13-binding protein (JRAB). Members of this family, which includes MICAL-2, MICAL-3, and similar proteins, contain one CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409044 [Multi-domain]  Cd Length: 110  Bit Score: 45.80  E-value: 3.26e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLD-PEDVDVPHPDEKSIITYVSSLYDV 170
Cdd:cd21195     47 PELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTgKEMASAQEPDKLSMVMYLSKFYEL 107
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1538-1902 3.64e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.12  E-value: 3.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1538 DKLKKQQKEANTAREEAEqeleiwrqkaNEALRLRLQAEEEAQKKSHAQEEAEK-QKLEAERDAKKRGKAEEAALKQK-- 1614
Cdd:pfam05557   16 NEKKQMELEHKRARIELE----------KKASALKRQLDRESDRNQELQKRIRLlEKREAEAEEALREQAELNRLKKKyl 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1615 ENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLkNEVNSTEKQRKQledELNKVRSEMDSL 1694
Cdd:pfam05557   86 EALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEEL-QERLDLLKAKAS---EAEQLRQNLEKQ 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1695 LQMKINAEkASMVNTEKSKQLLESEALKMKQLADEAARMRSVaeEAKKQRQIAEEEAARQRSEAEKILKEKLAAINeaTR 1774
Cdd:pfam05557  162 QSSLAEAE-QRIKELEFEIQSQEQDSEIVKNSKSELARIPEL--EKELERLREHNKHLNENIENKLLLKEEVEDLK--RK 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1775 LKTEAEMALKAKEAENERLKRQAEEEAYQrKLLEDQAAQHK--QDIEEKITQLQtSSDSELGRQKNIVEETLKQKKVVEE 1852
Cdd:pfam05557  237 LEREEKYREEAATLELEKEKLEQELQSWV-KLAQDTGLNLRspEDLSRRIEQLQ-QREIVLKEENSSLTSSARQLEKARR 314

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1853 EIHIIKINfhkASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKL 1902
Cdd:pfam05557  315 ELEQELAQ---YLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAI 361
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2296-2515 3.86e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 3.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2296 ASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKH--TTEIVVQKLETQRLQSTREADDLKSAIADlee 2373
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiaALARRIRALEQELAALEAELAELEKEIAE--- 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2374 erkklkkeaeelQRKSKEmanAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEgekkrfekQLEDEMKKAKALKDEQERQ 2453
Cdd:COG4942     95 ------------LRAELE---AQKEELAELLRALYRLGRQPPLALLLSPEDFL--------DAVRRLQYLKYLAPARREQ 151

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2454 RKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQ 2515
Cdd:COG4942    152 AEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAA 213
CH_SMTNL2 cd21261
calponin homology (CH) domain found in smoothelin-like protein 2; Smoothelin-like protein 2 ...
 111-169 4.08e-05

calponin homology (CH) domain found in smoothelin-like protein 2; Smoothelin-like protein 2 (SMTNL2) is highly expressed in skeletal muscle and could be associated with differentiating myocytes. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409110  Cd Length: 107  Bit Score: 45.73  E-value: 4.08e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDV--PHPDEKSIITYVSSLYD 169
Cdd:cd21261     44 PEAFDYDSLSPSNRKHNFELAFSMAEKLANCDRLIEVEDMMVmgRKPDPMCVFTYVQSLYN 104
PRK01156 PRK01156
chromosome segregation protein; Provisional
 2105-2504 4.33e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.90  E-value: 4.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2105 ELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIeeenrrlmqKDKDSTQKLL 2184
Cdd:PRK01156   198 ELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEI---------KTAESDLSME 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2185 AEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRL 2264
Cdd:PRK01156   269 LEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNDYIKKKSRY 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2265 QEDKQQIQQRLDKETE--GFQKSLEAERKRQLEASAEAEKLKlrvKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHT 2342
Cdd:PRK01156   349 DDLNNQILELEGYEMDynSYLKSIESLKKKIEEYSKNIERMS---AFISEILKIQEIDPDAIKKELNEINVKLQDISSKV 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2343 TEIvvqkleTQRLQSTRE-ADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQsfltekgllLKR 2421
Cdd:PRK01156   426 SSL------NQRIRALREnLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIRE---------IEI 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2422 EKEVEGEKKRFEKQLEDEMKKAKAlkDEQERQRKLMEEERKKLQAIMD-EAVRKQKEAE-EEMKNKQREMDV--LDKKRL 2497
Cdd:PRK01156   491 EVKDIDEKIVDLKKRKEYLESEEI--NKSINEYNKIESARADLEDIKIkINELKDKHDKyEEIKNRYKSLKLedLDSKRT 568


                   ....*..
gi 1389908296 2498 EQEKQLA 2504
Cdd:PRK01156   569 SWLNALA 575
PLEC smart00250
Plectin repeat;
2976-3012 4.46e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 4.46e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2976 LNFLEAQAATGFVIDPIKNERVPVDEAVKSGLVGPEI 3012
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1932-2410 4.61e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 4.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1932 KAAQEEVERLKKKAEdankqkekaekeaekqvVLA--KEAAQKCTAAEQKA---QDVLSKNK--EDVLAQEKLRDEFENA 2004
Cdd:COG4913    238 ERAHEALEDAREQIE-----------------LLEpiRELAERYAAARERLaelEYLRAALRlwFAQRRLELLEAELEEL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2005 KKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAE 2084
Cdd:COG4913    301 RAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAE 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2085 -MSKHKKEAEQALQQKSQVEKELTVvklQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVR----------- 2152
Cdd:COG4913    381 eFAALRAEAAALLEALEEELEALEE---ALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRdalaealglde 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2153 ---------IQMEE------------------------------------------LVKLKLKIEEENRRLMQKDKDS-T 2180
Cdd:COG4913    458 aelpfvgelIEVRPeeerwrgaiervlggfaltllvppehyaaalrwvnrlhlrgrLVYERVRTGLPDPERPRLDPDSlA 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2181 QKLLAEE----AEKMKSLAEEAGRLSVEAEET-----------------------------ARQRQIAESNlAEQRALAE 2227
Cdd:COG4913    538 GKLDFKPhpfrAWLEAELGRRFDYVCVDSPEElrrhpraitragqvkgngtrhekddrrriRSRYVLGFDN-RAKLAALE 616

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2228 KILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQE------DKQQIQQRLDketegfqkSLEAERKRQLEASAEAE 2301
Cdd:COG4913    617 AELAELEEELAEAEERLEALEAELDALQERREALQRLAEyswdeiDVASAEREIA--------ELEAELERLDASSDDLA 688

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2302 KLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRtekhtteivvqkLETQRLQSTREADDLKSAIADLEEERKKLKKE 2381
Cdd:COG4913    689 ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQ------------AEEELDELQDRLEAAEDLARLELRALLEERFA 756

                          570       580
                   ....*....|....*....|....*....
gi 1389908296 2382 AEELQRKSKEMANAQQEQIEQQKAELQQS 2410
Cdd:COG4913    757 AALGDAVERELRENLEERIDALRARLNRA 785
PRK12704 PRK12704
phosphodiesterase; Provisional
 1352-1501 4.69e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.39  E-value: 4.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1352 LKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAElQELRDRAAEAEKLRKAAQDEAERLRKQVA 1431
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFE-KELRERRNELQKLEKRLLQKEENLDRKLE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1432 EETQRKKNAEDELKRKSDAEKEAAKQK-------QRALDDLQKY-KMQAEEA-ERRMKQAEE----EKIRQIRVVEEVAQ 1498
Cdd:PRK12704   104 LLEKREEELEKKEKELEQKQQELEKKEeeleeliEEQLQELERIsGLTAEEAkEILLEKVEEearhEAAVLIKEIEEEAK 183


                   ...
gi 1389908296 1499 KSA 1501
Cdd:PRK12704   184 EEA 186
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
2105-2300 4.91e-05

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 49.10  E-value: 4.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2105 ELTVVKLQlDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVElARVRI----QMEELVKLKLKIEEENRRLMQKDKDsT 2180
Cdd:COG2268    170 ELESVAIT-DLEDENNYLDALGRRKIAEIIRDARIAEAEAERE-TEIAIaqanREAEEAELEQEREIETARIAEAEAE-L 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2181 QKLLAE---EAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQA 2257
Cdd:COG2268    247 AKKKAEerrEAETARAEAEAAYEIAEANAEREVQRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAEAEAE 326

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1389908296 2258 QEtakrlqedKQQIQQRLDKETEGFQKSLEAERKRQLEASAEA 2300
Cdd:COG2268    327 AE--------AEAIRAKGLAEAEGKRALAEAWNKLGDAAILLM 361
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1981-2539 5.73e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.66  E-value: 5.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1981 QDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAEneaAKQAKAQNDTEKQRKEA 2060
Cdd:TIGR00606  230 EAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELE---LKMEKVFQGTDEQLNDL 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2061 EEEAARRAAAEAAALKQKQQadaEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVN-DAFK 2139
Cdd:TIGR00606  307 YHNHQRTVREKERELVDCQR---ELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLElDGFE 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2140 QKSQVEvelarvrIQMEELVKLKlkieeenRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNL 2219
Cdd:TIGR00606  384 RGPFSE-------RQIKNFHTLV-------IERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEIL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2220 AEQRALAEKILKEKMQAIQEATK-LKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASA 2298
Cdd:TIGR00606  450 EKKQEELKFVIKELQQLEGSSDRiLELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNH 529

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2299 EAEKLKlrvKELSLAQTKAEDEAKKFK---KQADEVKAQL---------------QRTEKHTTE-------IVVQKLETQ 2353
Cdd:TIGR00606  530 HTTTRT---QMEMLTKDKMDKDEQIRKiksRHSDELTSLLgyfpnkkqledwlhsKSKEINQTRdrlaklnKELASLEQN 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2354 RLQSTREADDLK---SAIADLEEERKKLKKEAEELQRKSKEMANA-QQEQIEQQKAELQQSFLTEKGL-------LLKRE 2422
Cdd:TIGR00606  607 KNHINNELESKEeqlSSYEDKLFDVCGSQDEESDLERLKEEIEKSsKQRAMLAGATAVYSQFITQLTDenqsccpVCQRV 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2423 KEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKL-------QAIMDEAVRKQKEAEEEMKNKQREMDVLDKK 2495
Cdd:TIGR00606  687 FQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrQSIIDLKEKEIPELRNKLQKVNRDIQRLKND 766

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2496 RLEQEKQLAEENKKL--------------REQLQTFEISSKTVSQTKESQTVSVEKLV 2539
Cdd:TIGR00606  767 IEEQETLLGTIMPEEesakvcltdvtimeRFQMELKDVERKIAQQAAKLQGSDLDRTV 824
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1346-1643 5.75e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.75  E-value: 5.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1346 QQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAER 1425
Cdd:COG4372     12 RLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1426 LRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQL 1505
Cdd:COG4372     92 AQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQ 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1506 QTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHA 1585
Cdd:COG4372    172 ELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEEL 251

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1586 QEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECI 1643
Cdd:COG4372    252 LEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSL 309
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1272-1516 5.78e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 5.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1272 EDDEKASEKLKEEERRKMAEIQAELDKQKQmaeahakSVAKAEQEALELKMKMKEeaskrqdvaadAEKQKQNIQQELQH 1351
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQA-------ELEELNEEYNELQAELEA-----------LQAEIDKLQAEIAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1352 LKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAE-LQELRDRAAEAEKLRKAAQDEAERLRKQV 1430
Cdd:COG3883     77 AE----AEIEERREELGERARALYRSGGSVSYLDVLLGSESFSDFLDRLSaLSKIADADADLLEELKADKAELEAKKAEL 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1431 AEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAM 1510
Cdd:COG3883    153 EAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232


                   ....*.
gi 1389908296 1511 SFSEQT 1516
Cdd:COG3883    233 AAAAAA 238
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1516-1704 5.90e-05

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 49.23  E-value: 5.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1516 TTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEaeqeleiwrQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLE 1595
Cdd:pfam05262  179 DKKVVEALREDNEKGVNFRRDMTDLKERESQEDAKRAQ---------QLKEELDKKQIDADKAQQKADFAQDNADKQRDE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1596 AERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKlsAEQECIRLKADFEHAEQQrglldnelqrLKNEVNSTEK 1675
Cdd:pfam05262  250 VRQKQQEAKNLPKPADTSSPKEDKQVAENQKREIEKAQIE--IKKNDEEALKAKDHKAFD----------LKQESKASEK 317

                          170       180
                   ....*....|....*....|....*....
gi 1389908296 1676 QRKQLEDELNKVRSEMDSLLQMKINAEKA 1704
Cdd:pfam05262  318 EAEDKELEAQKKREPVAEDLQKTKPQVEA 346
CH_SMTNA cd21258
calponin homology (CH) domain found in smoothelin-A and similar proteins; Smoothelins are ...
 111-173 6.12e-05

calponin homology (CH) domain found in smoothelin-A and similar proteins; Smoothelins are actin-binding cytoskeletal proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. This model corresponds to the single CH domain of smoothelin-A. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409107  Cd Length: 111  Bit Score: 45.04  E-value: 6.12e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDV--PHPDEKSIITYVSSLYDVMPR 173
Cdd:cd21258     44 PDAFDYSQLSPQNRRQNFEVAFSAAEMLADCVPLVEVEDMMImgKKPDSKCVFTYVQSLYNHLRR 108
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1413-1683 6.24e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.61  E-value: 6.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1413 EKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQaeeAERRMKQAEEEKIRQIRv 1492
Cdd:TIGR00927  628 GDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIP---AERKGEQEGEGEIEAKE- 703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1493 vEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLR 1572
Cdd:TIGR00927  704 -ADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGE 782

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1573 LQAEEEAQKKShaqEEAEKQKLEAERDAKKRGKAEEaalkqkENAEKELDKQRKFAEQIAQQKLSAEQECiRLKADFEHA 1652
Cdd:TIGR00927  783 IQAGEDGEMKG---DEGAEGKVEHEGETEAGEKDEH------EGQSETQADDTEVKDETGEQELNAENQG-EAKQDEKGV 852

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1389908296 1653 EQQRGLL--DNELQRLKNEVNSTEKQRKQLEDE 1683
Cdd:TIGR00927  853 DGGGGSDggDSEEEEEEEEEEEEEEEEEEEEEE 885
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1417-1762 6.44e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.75  E-value: 6.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1417 KAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEV 1496
Cdd:COG4372     41 DKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEEL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1497 AQksaatqlqtkamsfseQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAE 1576
Cdd:COG4372    121 QK----------------ERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQA 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1577 EEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQR 1656
Cdd:COG4372    185 LDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELE 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1657 GLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSV 1736
Cdd:COG4372    265 LAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQ 344

                          330       340
                   ....*....|....*....|....*.
gi 1389908296 1737 AEEAKKQRQIAEEEAARQRSEAEKIL 1762
Cdd:COG4372    345 LLLVGLLDNDVLELLSKGAEAGVADG 370
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2434-2516 6.61e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 6.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2434 KQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQ 2513
Cdd:COG4942     30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEL 109


                   ...
gi 1389908296 2514 LQT 2516
Cdd:COG4942    110 LRA 112
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 1543-1620 6.71e-05

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 46.75  E-value: 6.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1543 QQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQ------KKSHAQEEAEKQKLEaERDAKKRGKAEEAALKQKEN 1616
Cdd:pfam06936   62 RQRSSDHSAATVDPDLVVKRQEALEASRLRMQEELDAQaekfkeKQKQLEEEKRRQKIE-MWESMQEGKSYKGNAKLAQE 140


                   ....
gi 1389908296 1617 AEKE 1620
Cdd:pfam06936  141 ETEE 144
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2253-2560 6.76e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 6.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2253 QKDQAQETAKRLQEDKQQIQQRLDKetegFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVK 2332
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDA----LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2333 AQLQRTEKHTTEIVVqkletqrLQSTREADDLKSAIADLeeerkklkkeaeelqrksKEMANAQQEQIEQQKAELQqsfl 2412
Cdd:COG3883     93 RALYRSGGSVSYLDV-------LLGSESFSDFLDRLSAL------------------SKIADADADLLEELKADKA---- 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2413 tekglllkrekevegEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVL 2492
Cdd:COG3883    144 ---------------ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAA 208

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2493 DKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKLVAVTTVGTSKGVLNGSTEVDGV 2560
Cdd:COG3883    209 EAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGAAGAAAGAAGAGA 276
CH_MICAL3 cd21251
calponin homology (CH) domain found in molecule interacting with CasL protein 3; MICAL-3 is a ...
 93-171 7.02e-05

calponin homology (CH) domain found in molecule interacting with CasL protein 3; MICAL-3 is a [F-actin]-monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). MICAL-3 seems to act as a Rab effector protein and plays a role in vesicle trafficking. It is involved in exocytic vesicle tethering and fusion. MICAL3 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409100 [Multi-domain]  Cd Length: 111  Bit Score: 44.94  E-value: 7.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296   93 QEQAQSYRGHYVQRVTRV---------------PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDV-DVPHPD 156
Cdd:cd21251     15 QRQTEGYAGVNVTDLTMSwksglalcaiihryrPDLIDFDSLDEQDVEKNNQLAFDIAEKEFGISPIMTGKEMaSVGEPD 94

                           90
                   ....*....|....*
gi 1389908296  157 EKSIITYVSSLYDVM 171
Cdd:cd21251     95 KLSMVMYLTQFYEMF 109
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1426-1862 7.02e-05

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 49.13  E-value: 7.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1426 LRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQ---AEEEKIRQIRVVEEVAQKSAA 1502
Cdd:pfam15964  319 VRSSLAEAQQRESSAYEQVKQAVQMTEEANFEKTKALIQCEQLKSELERQKERLEKelaSQQEKRAQEKEALRKEMKKER 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1503 TQLQTKAMSFSEqttkleeslkkeqgNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEAL-RLRLQAEEEAQK 1581
Cdd:pfam15964  399 EELGATMLALSQ--------------NVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMDVTKVCgEMRYQLNQTKMK 464

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1582 KshaqEEAEKQKLEAErdaKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDN 1661
Cdd:pfam15964  465 K----DEAEKEHREYR---TKTGRQLEIKDQEIEKLGLELSESKQRLEQAQQDAARAREECLKLTELLGESEHQLHLTRL 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1662 E----LQRLKNEVNSTEKQRKQLEDELNKvrsemdSLLQMKINAEKAsmVNTEKSkqLLESEALKMKQLADEAARMrsva 1737
Cdd:pfam15964  538 EkesiQQSFSNEAKAQALQAQQREQELTQ------KMQQMEAQHDKT--VNEQYS--LLTSQNTFIAKLKEECCTL---- 603

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1738 eeAKKQRQIAEeeaaRQRSEAEKILKEKLAAINEAtrlkteaemalkakeaenERLKRQAEEeayqrklLEDQAAQH--- 1814
Cdd:pfam15964  604 --AKKLEEITQ----KSRSEVEQLSQEKEYLQDRL------------------EKLQKRNEE-------LEEQCVQHgrm 652

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 1815 KQDIEEKITQL----QTSSdSELGRQKNIVEETLKQKKVVEEEIHIIKINFH 1862
Cdd:pfam15964  653 HERMKQRLRQLdkhcQATA-QQLVQLLSKQNQLFKERQNLTEEVQSLRSQVP 703
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1732-2532 7.13e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.27  E-value: 7.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1732 RMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMAlKAKEAENERLKRQaeeeayQRKLLEDQA 1811
Cdd:TIGR00606  190 TLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIV-KSYENELDPLKNR------LKEIEHNLS 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1812 AQHKqdIEEKITQLQTSsdsELGRQKNIVEETLKQKKV---VEEEIHIIKINFHKASKEK----ADLESELKKLkgiade 1884
Cdd:TIGR00606  263 KIMK--LDNEIKALKSR---KKQMEKDNSELELKMEKVfqgTDEQLNDLYHNHQRTVREKerelVDCQRELEKL------ 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1885 TQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRitaaeeEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVV 1964
Cdd:TIGR00606  332 NKERRLLNQEKTELLVEQGRLQLQADRHQEHIRAR------DSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQED 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1965 LAKEAAQKCTaaeqkaqDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAA 2044
Cdd:TIGR00606  406 EAKTAAQLCA-------DLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQ 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2045 KQAKAQNDTEKQRKEAEEEAARRAAAEAaalkQKQQADAEMSKhKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLD 2124
Cdd:TIGR00606  479 ELRKAERELSKAEKNSLTETLKKEVKSL----QNEKADLDRKL-RKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRK 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2125 QELQRV------------KGEVNDAF----KQKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLaeEA 2188
Cdd:TIGR00606  554 IKSRHSdeltsllgyfpnKKQLEDWLhsksKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLF--DV 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2189 EKMKSLAEEAGRLSVEAEETARQRQI--AESNLAEQRAL------------------AEKILKEKMQAIQEATKL----K 2244
Cdd:TIGR00606  632 CGSQDEESDLERLKEEIEKSSKQRAMlaGATAVYSQFITqltdenqsccpvcqrvfqTEAELQEFISDLQSKLRLapdkL 711

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2245 AEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQksleaERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKK- 2323
Cdd:TIGR00606  712 KSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELR-----NKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKv 786

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2324 ----------FKKQADEVK----AQLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKS 2389
Cdd:TIGR00606  787 cltdvtimerFQMELKDVErkiaQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKT 866

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2390 KEM---------ANAQQEQIEQQKAELQ---QSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLM 2457
Cdd:TIGR00606  867 NELkseklqigtNLQRRQQFEEQLVELStevQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDI 946

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 2458 EEERKKLQAIMDEAVRK-QKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQT 2532
Cdd:TIGR00606  947 KEKVKNIHGYMKDIENKiQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLT 1022
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1618-1772 7.16e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.61  E-value: 7.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1618 EKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRS--EMDSLL 1695
Cdd:COG1579     16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNnkEYEALQ 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1696 QmkinaEKASMvntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEA 1772
Cdd:COG1579     96 K-----EIESL---KRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 2433-2582 7.81e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 49.05  E-value: 7.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2433 EKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQ--------KEAEEEMKNKQREMDVLDKKRLEQ--EKQ 2502
Cdd:PRK00409   529 ERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAekeaqqaiKEAKKEADEIIKELRQLQKGGYASvkAHE 608

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2503 LAEENKKLREQLQTFEisSKTVSQTKESQTVSVEKLVAVTTVGtSKGvlngstEVDGVKKEGDSPLSFEGIREKVPAERL 2582
Cdd:PRK00409   609 LIEARKRLNKANEKKE--KKKKKQKEKQEELKVGDEVKYLSLG-QKG------EVLSIPDDKEAIVQAGIMKMKVPLSDL 679
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1803-2001 8.70e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 48.26  E-value: 8.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1803 QRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLK---QKKVVEEEIHIIKINfHKASKEKADLESELKKLK 1879
Cdd:PRK09510    70 QQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAaqeQKKQAEEAAKQAALK-QKQAEEAAAKAAAAAKAK 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1880 GIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEkvkritaAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEA 1959
Cdd:PRK09510   149 AEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAK-------KKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAA 221

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1389908296 1960 EKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEF 2001
Cdd:PRK09510   222 EAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLF 263
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
2220-2494 8.90e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.86  E-value: 8.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2220 AEQRALAEKILKEKMQAIQEATklkaeaekLQKQKDQAQETAKRLQEDKQQIQQRLDKetegFQKSLEAERKRQLEASAE 2299
Cdd:COG3206    144 SPDPELAAAVANALAEAYLEQN--------LELRREEARKALEFLEEQLPELRKELEE----AEAALEEFRQKNGLVDLS 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2300 AEKLKL--RVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEI----VVQKLETQRLQSTREADDLKSaiadlee 2373
Cdd:COG3206    212 EEAKLLlqQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELlqspVIQQLRAQLAELEAELAELSA------- 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2374 erkklkkeaeELQRKSKEMANAQQE------QIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEmkkakalk 2447
Cdd:COG3206    285 ----------RYTPNHPDVIALRAQiaalraQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL-------- 346

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 2448 DEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDK 2494
Cdd:COG3206    347 PELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVIDP 393
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
2201-2339 9.09e-05

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 48.12  E-value: 9.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2201 LSVEAEETARQRQIAESNLAEQRALAEKiLKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQE-DKQQI--QQRLDk 2277
Cdd:COG1566     74 ARLDPTDLQAALAQAEAQLAAAEAQLAR-LEAELGAEAEIAAAEAQLAAAQAQLDLAQRELERYQAlYKKGAvsQQELD- 151

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2278 etegfQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTK-AEDEAKKFKKQADEVKAQLQRTE 2339
Cdd:COG1566    152 -----EARAALDAAQAQLEAAQAQLAQAQAGLREEEELAaAQAQVAQAEAALAQAELNLARTT 209
SAC6 COG5069
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];
110-168 9.40e-05

Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];


Pssm-ID: 227401 [Multi-domain]  Cd Length: 612  Bit Score: 48.78  E-value: 9.40e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296  110 VPALIDMNQVYRQSNQE--NLEQAFSVAERELGVTKLLDPEDV-DVPHPDEKSIITYVSSLY 168
Cdd:COG5069    168 RPDTLDPNVLDLQKKNKalNNFQAFENANKVIGIARLIGVEDIvNVSIPDERSIMTYVSWYI 229
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1266-1639 9.41e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 49.03  E-value: 9.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1266 DAQRRLEDDEKASEKLKEEERRKMAEIQAeLDKQKQMAEAHAKSVAKAEQ----------EALELKMKMKEEASKRQDVA 1335
Cdd:PRK10246   527 VNQSRLDALEKEVKKLGEEGAALRGQLDA-LTKQLQRDESEAQSLRQEEQaltqqwqavcASLNITLQPQDDIQPWLDAQ 605

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1336 ADAEKQKQNIQQELQHLKSLSDQEikSKNQQLEDALVSRRkieeeiHIIRIQLEKTTAHKAKSEAELQELRDRAAEAeKL 1415
Cdd:PRK10246   606 EEHERQLRLLSQRHELQGQIAAHN--QQIIQYQQQIEQRQ------QQLLTALAGYALTLPQEDEEASWLATRQQEA-QS 676

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1416 RKAAQDEAERLRKQVAeetqRKKNAEDELKRKSDAEKEAAKQkqrALDDLQKYKMQ--AEEAERRMKQAEEEKIRQiRVV 1493
Cdd:PRK10246   677 WQQRQNELTALQNRIQ----QLTPLLETLPQSDDLPHSEETV---ALDNWRQVHEQclSLHSQLQTLQQQDVLEAQ-RLQ 748

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1494 EEVAQKSAATQlqtkAMSFSEQTTKLEESLKKEqgNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRL 1573
Cdd:PRK10246   749 KAQAQFDTALQ----ASVFDDQQAFLAALLDEE--TLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHRPDGLDLTV 822

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1574 QAEEeaqkkSHAQEEAEKQKLeaeRDAKKRGKAEEAALKQKENAEKEldkQRKFAEQIAQQKLSAE 1639
Cdd:PRK10246   823 TVEQ-----IQQELAQLAQQL---RENTTRQGEIRQQLKQDADNRQQ---QQALMQQIAQATQQVE 877
PRK12704 PRK12704
phosphodiesterase; Provisional
 1496-1640 9.44e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 48.62  E-value: 9.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1496 VAQKSAATQL---QTKAMSFSEQTTKLEESLKKEQgnVLKLQEEADKLkkqqkeantaREEAEQELEIWRQKANEALRlR 1572
Cdd:PRK12704    24 VRKKIAEAKIkeaEEEAKRILEEAKKEAEAIKKEA--LLEAKEEIHKL----------RNEFEKELRERRNELQKLEK-R 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1573 LQAEEEAQKKShaQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQqkLSAEQ 1640
Cdd:PRK12704    91 LLQKEENLDRK--LELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISG--LTAEE 154
PLEC smart00250
Plectin repeat;
4195-4228 1.08e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  4195 EETGPIAGILDTDTLEKVSVTEAIHRNLVDNITG 4228
Cdd:smart00250    5 EAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1572-1847 1.12e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.92  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1572 RLQAEEEAQKKshAQEEAEKQKLEAERDAKKRGKAEEAALKQKEnAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEh 1651
Cdd:TIGR02794   54 RIQQQKKPAAK--KEQERQKKLEQQAEEAEKQRAAEQARQKELE-QRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQA- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1652 AEQQRGLLDNELQRLKnevnstEKQRKQLEDElnkvrsemdsllqmkinaekasmvntekskqllesealkmkQLADEAA 1731
Cdd:TIGR02794  130 AEAKAKAEAEAERKAK------EEAAKQAEEE-----------------------------------------AKAKAAA 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1732 RMRSVAEEAKKQrqiAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQA 1811
Cdd:TIGR02794  163 EAKKKAEEAKKK---AEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFG 239

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1389908296 1812 AQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQK 1847
Cdd:TIGR02794  240 LASGSNAEKQGGARGAAAGSEVDKYAAIIQQAIQQN 275
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 2126-2565 1.18e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 48.20  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2126 ELQRVKGEVNDAFKQKSQVEVELARVRIQMEELV---KLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLS 2202
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKAsalKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKK 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2203 VEAEETARQRQIAESNLAEQRALAEKILKEkmqaiqeatkLKAEAEKLQKQKDQAQETAKRLQEdkqqIQQRLDKETEGF 2282
Cdd:pfam05557   83 KYLEALNKKLNEKESQLADAREVISCLKNE----------LSELRRQIQRAELELQSTNSELEE----LQERLDLLKAKA 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2283 Q-----------------------KSLEAERKRQLEASAEAEKLK---LRVKELSLAQTKAEDEAKKF----------KK 2326
Cdd:pfam05557  149 SeaeqlrqnlekqqsslaeaeqriKELEFEIQSQEQDSEIVKNSKselARIPELEKELERLREHNKHLnenienklllKE 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QADEVKAQLQRTEKHTTEIVVQKLETQRLQstREADDLKSAIADLEEERkklkkeaeelqrKSKEMANAQQEQIEQQKAE 2406
Cdd:pfam05557  229 EVEDLKRKLEREEKYREEAATLELEKEKLE--QELQSWVKLAQDTGLNL------------RSPEDLSRRIEQLQQREIV 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2407 LQQ---SFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQER-QRK--LMEEERKKLQAIMDEAVRKQKEAEE 2480
Cdd:pfam05557  295 LKEensSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRlQRRvlLLTKERDGYRAILESYDKELTMSNY 374

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2481 EMKNKQREMDVLDkkrLEQEKQLAEENKKLR-EQLQTFEISSKTVSQTKESQTVSVEKLVAVTTVGTSKgvlngsTEVDG 2559
Cdd:pfam05557  375 SPQLLERIEEAED---MTQKMQAHNEEMEAQlSVAEEELGGYKQQAQTLERELQALRQQESLADPSYSK------EEVDS 445


                   ....*.
gi 1389908296 2560 VKKEGD 2565
Cdd:pfam05557  446 LRRKLE 451
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1417-1902 1.29e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 48.36  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1417 KAAQDEAERLRKQVAEETQRKKNAEDELKRKS----------DAEKEAAKQKQRALDDLQKYKMQAEEAERRmKQAEEEK 1486
Cdd:PRK01156   193 KSSNLELENIKKQIADDEKSHSITLKEIERLSieynnamddyNNLKSALNELSSLEDMKNRYESEIKTAESD-LSMELEK 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1487 IRQIRVVEE---------------------------VAQKSAATQLQTKAMSFSEQTTKLEEsLKKEQGNVLKLQEEADK 1539
Cdd:PRK01156   272 NNYYKELEErhmkiindpvyknrnyindyfkykndiENKKQILSNIDAEINKYHAIIKKLSV-LQKDYNDYIKKKSRYDD 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1540 LKKQQKEA-------NTAREEAEQeLEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALK 1612
Cdd:PRK01156   351 LNNQILELegyemdyNSYLKSIES-LKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLN 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1613 QKENAEKE-LDKQRKFAEQiaqqkLSAEQECIRLKADF--EHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRS 1689
Cdd:PRK01156   430 QRIRALREnLDELSRNMEM-----LNGQSVCPVCGTTLgeEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKK 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1690 EMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEE------------------AKKQRQIAEEEA 1751
Cdd:PRK01156   505 RKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRykslkledldskrtswlnALAVISLIDIET 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1752 ARQRSEaekilkEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAY----QRKLLEDQAAQhKQDIEEKITQLQT 1827
Cdd:PRK01156   585 NRSRSN------EIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANnlnnKYNEIQENKIL-IEKLRGKIDNYKK 657

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 1828 SSDSELGRQKNIVEETLKQKKvVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKL 1902
Cdd:PRK01156   658 QIAEIDSIIPDLKEITSRIND-IEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKI 731
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1644-1898 1.30e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 47.21  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1644 RLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQmKINAEKASMVNTEKSKQLLESEALKM 1723
Cdd:COG1340     19 ELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNE-KVKELKEERDELNEKLNELREELDEL 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1724 KQLADEAARMRsvAEEAKKQRQIAEEEAARQRS----EAEKILKEKLAAINE-ATRLKTEAEMALKAKEAENE--RLKRQ 1796
Cdd:COG1340     98 RKELAELNKAG--GSIDKLRKEIERLEWRQQTEvlspEEEKELVEKIKELEKeLEKAKKALEKNEKLKELRAElkELRKE 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1797 AEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEetlKQKKVVEEEIHIIKInfhkaSKEKADLESELK 1876
Cdd:COG1340    176 AEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVE---AQEKADELHEEIIEL-----QKELRELRKELK 247

                          250       260
                   ....*....|....*....|..
gi 1389908296 1877 KLKGIADETQKSKLKAEEEAEK 1898
Cdd:COG1340    248 KLRKKQRALKREKEKEELEEKA 269
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1716-1943 1.50e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1716 LESEALKMKQLADEAARMRSVAEEAKKQRQIAEE-EAARQRSEAEKILKEKLAAINEATRLKTeAEMALKAKEAENERLK 1794
Cdd:COG4913    223 TFEAADALVEHFDDLERAHEALEDAREQIELLEPiRELAERYAAARERLAELEYLRAALRLWF-AQRRLELLEAELEELR 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1795 RQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSdselGRQKNIVEETLKQKKvveeeihiikinfhkasKEKADLESE 1874
Cdd:COG4913    302 AELARLEAELERLEARLDALREELDELEAQIRGNG----GDRLEQLEREIERLE-----------------RELEERERR 360

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1875 LKKLkgiADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKK 1943
Cdd:COG4913    361 RARL---EALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEA 426
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1879-2099 1.60e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.15  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1879 KGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAA--EEEAARQCKAAQEEVERLKKKAEdankqkekae 1956
Cdd:TIGR02794   60 KPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAkqAEQAAKQAEEKQKQAEEAKAKQA---------- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1957 keaekqvvlaKEAAQKCTA-AEQKAQDVLSKNKEdvlaQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQ 2035
Cdd:TIGR02794  130 ----------AEAKAKAEAeAERKAKEEAAKQAE----EEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2036 KKA------AENEAAKQA----KAQNDTEKQRKEAEEEAARRAAAEAAALKQKQ------QADAEMSKHKKEAEQALQQK 2099
Cdd:TIGR02794  196 AKAeaakakAAAEAAAKAeaeaAAAAAAEAERKADEAELGDIFGLASGSNAEKQggargaAAGSEVDKYAAIIQQAIQQN 275
mukB PRK04863
chromosome partition protein MukB;
1268-1949 1.62e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.03  E-value: 1.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1268 QRRLEDDEKASEKLKEEErrkmaEIQAELDKQKQMAEAHAKSvakAEQEALELKMKMKEeASKRQDVAADAEKQKQNIQQ 1347
Cdd:PRK04863   351 ERYQADLEELEERLEEQN-----EVVEEADEQQEENEARAEA---AEEEVDELKSQLAD-YQQALDVQQTRAIQYQQAVQ 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1348 ELQHLKSLSD-------------QEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEK------------------------ 1390
Cdd:PRK04863   422 ALERAKQLCGlpdltadnaedwlEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQayqlvrkiagevsrseawdvarel 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1391 -TTAHKAKSEAE-LQELRDRAAEAEKlRKAAQDEAERLRKQVAEETQRKKNAEDELkrksdaEKEAAKQKQRaLDDLQKY 1468
Cdd:PRK04863   502 lRRLREQRHLAEqLQQLRMRLSELEQ-RLRQQQRAERLLAEFCKRLGKNLDDEDEL------EQLQEELEAR-LESLSES 573

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1469 KmqAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTtklEESLKKEQGNVLKLQEEADKLKKQQKEAN 1548
Cdd:PRK04863   574 V--SEARERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQS---GEEFEDSQDVTEYMQQLLERERELTVERD 648

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1549 TAREEAEQ-ELEIWR---QKANEALRLRLQAE----------------EEAQKKS-------HA----QEEAEKQKLEAE 1597
Cdd:PRK04863   649 ELAARKQAlDEEIERlsqPGGSEDPRLNALAErfggvllseiyddvslEDAPYFSalygparHAivvpDLSDAAEQLAGL 728

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1598 RD---------------AKKRGKAEE--AALKQKENA-------------------EKELDKQRKFAEQIAQQ--KLSAE 1639
Cdd:PRK04863   729 EDcpedlyliegdpdsfDDSVFSVEEleKAVVVKIADrqwrysrfpevplfgraarEKRIEQLRAEREELAERyaTLSFD 808

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1640 -QECIRLKADFEH--------------------AEQQRGLLDNELQRLKNEVNSTEKQRKQLE---DELNKVRSEMDSL- 1694
Cdd:PRK04863   809 vQKLQRLHQAFSRfigshlavafeadpeaelrqLNRRRVELERALADHESQEQQQRSQLEQAKeglSALNRLLPRLNLLa 888

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1695 ---LQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEE-AKKQRQIAEEEAARQRSEAEKILkekLAAIN 1770
Cdd:PRK04863   889 detLADRVEEIREQLDEAEEAKRFVQQHGNALAQLEPIVSVLQSDPEQfEQLKQDYQQAQQTQRDAKQQAFA---LTEVV 965

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1771 E-ATRLKTEAEMALKAKEAE-NERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKiTQLQTSSDSELGRQKNIVEEtlkqkk 1848
Cdd:PRK04863   966 QrRAHFSYEDAAEMLAKNSDlNEKLRQRLEQAEQERTRAREQLRQAQAQLAQY-NQVLASLKSSYDAKRQMLQE------ 1038

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1849 vveeeihiikinfhkaskekadLESELKKLKGIADETQKSKLKAEEEaeKLKKLAAEEERRRKEAEEKVKRITAAEEEAA 1928
Cdd:PRK04863  1039 ----------------------LKQELQDLGVPADSGAEERARARRD--ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094

                          810       820
                   ....*....|....*....|.
gi 1389908296 1929 RQCKAAQEEVERLKKKAEDAN 1949
Cdd:PRK04863  1095 KKLRKLERDYHEMREQVVNAK 1115
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1612-1996 1.69e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 47.64  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1612 KQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSem 1691
Cdd:COG5185    142 KLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSES-- 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1692 dslLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEaarmrsvAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINE 1771
Cdd:COG5185    220 ---TLLEKAKEIINIEEALKGFQDPESELEDLAQTSDK-------LEKLVEQNTDLRLEKLGENAESSKRLNENANNLIK 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1772 ATRlKTEAEMALKAKEAENERLKRQAEEEAyQRKLLEDQAAQHKQDIEEKITQLQtssdSELGRQKNIVEEtlKQKKVVE 1851
Cdd:COG5185    290 QFE-NTKEKIAEYTKSIDIKKATESLEEQL-AAAEAEQELEESKRETETGIQNLT----AEIEQGQESLTE--NLEAIKE 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1852 EEIHIIKINFHKASKEKAD-LESELKKLKGIADETQKSKLKAEEE-AEKLKKLAAEEERRRKEAEEKVKRITAAEEEAAR 1929
Cdd:COG5185    362 EIENIVGEVELSKSSEELDsFKDTIESTKESLDEIPQNQRGYAQEiLATLEDTLKAADRQIEELQRQIEQATSSNEEVSK 441

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1930 QCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAK--EAAQKCTAAEQKAQDVLSKNKEDVLAQEK 1996
Cdd:COG5185    442 LLNELISELNKVMREADEESQSRLEEAYDEINRSVRSKkeDLNEELTQIESRVSTLKATLEKLRAKLER 510
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1372-1589 1.70e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 47.64  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1372 VSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQE--------LRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKnaEDE 1443
Cdd:pfam15709  350 VERKRREQEEQRRLQQEQLERAEKMREELELEQqrrfeeirLRKQRLEEERQRQEEEERKQRLQLQAAQERARQQ--QEE 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1444 LKRKsdaekeaakqkqraLDDLQKyKMQAEEAERrmkqAEEEKIRQirvveevaqksaatqlqtkamsfseqtTKLEESL 1523
Cdd:pfam15709  428 FRRK--------------LQELQR-KKQQEEAER----AEAEKQRQ---------------------------KELEMQL 461

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1524 KKEQGNVLKLQEEADKLKKQQKEanTAREEAEQELEIWRQKANEALRLrlqAEEEAQKKshAQEEA 1589
Cdd:pfam15709  462 AEEQKRLMEMAEEERLEYQRQKQ--EAEEKARLEAEERRQKEEEAARL---ALEEAMKQ--AQEQA 520
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2296-2569 1.71e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2296 ASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHtteivVQKLETQRLQSTREADDLKSAIADLeeer 2375
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE-----LEALQAEIDKLQAEIAEAEAEIEER---- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2376 kklkkeaeelQRKSKEMANAQQEQIEQQK-------AELQQSFLTEKGLLlkrekevegekKRFEKQLEDEMKKAKALKD 2448
Cdd:COG3883     85 ----------REELGERARALYRSGGSVSyldvllgSESFSDFLDRLSAL-----------SKIADADADLLEELKADKA 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2449 EQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTK 2528
Cdd:COG3883    144 ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAA 223

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1389908296 2529 ESQTVSVEKLVAVTTVGTSKGVLNGSTEVDGVKKEGDSPLS 2569
Cdd:COG3883    224 AAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGA 264
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1274-1455 1.80e-04

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 47.69  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1274 DEKASEKLKEEErrkmaeiQAELDKQKQMAEAHAKSvakaEQEALELKMKMKEEASKRQDVAAD-----------AEKQK 1342
Cdd:pfam05262  179 DKKVVEALREDN-------EKGVNFRRDMTDLKERE----SQEDAKRAQQLKEELDKKQIDADKaqqkadfaqdnADKQR 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSLSD----QEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAkseaelQELRDRAAEAEKLRKA 1418
Cdd:pfam05262  248 DEVRQKQQEAKNLPKpadtSSPKEDKQVAENQKREIEKAQIEIKKNDEEALKAKDHKA------FDLKQESKASEKEAED 321

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1389908296 1419 AQDEAERLRKQVAEETQRKKNaedELKRKSDAEKEAA 1455
Cdd:pfam05262  322 KELEAQKKREPVAEDLQKTKP---QVEAQPTSLNEDA 355
CH_SMTN-like cd21200
calponin homology (CH) domain found in the smoothelin family; The smoothelin family includes ...
 111-168 1.85e-04

calponin homology (CH) domain found in the smoothelin family; The smoothelin family includes smoothelin and smoothelin-like proteins. Smoothelins are actin-binding cytoskeletal proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. SMTNL1, also called calponin homology-associated smooth muscle protein (CHASM), plays a role in the regulation of contractile properties of both striated and smooth muscles. It can bind to calmodulin and tropomyosin. When it is unphosphorylated, SMTNL1 may inhibit myosin dephosphorylation. SMTNL2 is highly expressed in skeletal muscle and could be associated with differentiating myocytes. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409049  Cd Length: 107  Bit Score: 43.49  E-value: 1.85e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPEDVDV--PHPDEKSIITYVSSLY 168
Cdd:cd21200     44 PDAFDYSSLDPKNRRKNFELAFSTAEELADIAPLLEVEDMVRmgNRPDWKCVFTYVQSLY 103
Caldesmon pfam02029
Caldesmon;
2204-2515 1.92e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 47.55  E-value: 1.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2204 EAEETARQRqiaesnlaEQRALAEKI-LKEKMQAIQEATKLKAEAEKLQKQKDQ-AQETAKRLQEDKQQIQQRLDKETEG 2281
Cdd:pfam02029    3 DEEEAARER--------RRRAREERRrQKEEEEPSGQVTESVEPNEHNSYEEDSeLKPSGQGGLDEEEAFLDRTAKREER 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2282 FQKSLE--AERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTR 2359
Cdd:pfam02029   75 RQKRLQeaLERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2360 EADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQ--IEQQK-----AELQQSFLTEKGLLLKREKEVEGEKKRF 2432
Cdd:pfam02029  155 EGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESkvFLDQKrghpeVKSQNGEEEVTKLKVTTKRRQGGLSQSQ 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2433 EKQLEDEMKKAKALKDEQERQR--KLMEEERKKLQaimdeavRKQKEAEEEM---------KNKQREMDVLDKKRLEQEK 2501
Cdd:pfam02029  235 EREEEAEVFLEAEQKLEELRRRrqEKESEEFEKLR-------QKQQEAELELeelkkkreeRRKLLEEEEQRRKQEEAER 307

                          330
                   ....*....|....*.
gi 1389908296 2502 QLA--EENKKLREQLQ 2515
Cdd:pfam02029  308 KLReeEEKRRMKEEIE 323
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1150-1376 1.95e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1150 LTEARQRQEKIQAVPISDSRALREQLTDEKKLLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYKALQDPIASPLKK 1229
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1230 PKMECAsDDIIQEYVNlrTRYSELMTLTNQyiKFIIDAQRRLEDDEKASEKLKEEeRRKMAEIQAELDKQKQMAEAHAKS 1309
Cdd:COG4942    102 QKEELA-ELLRALYRL--GRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQ-AEELRADLAELAALRAELEAERAE 175

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1310 VAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSlSDQEIKSKNQQLEDALVSRRK 1376
Cdd:COG4942    176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ-EAEELEALIARLEAEAAAAAE 241
mukB PRK04863
chromosome partition protein MukB;
1404-2230 1.96e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.03  E-value: 1.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1404 ELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSD------AEKEAAKQKQRALDDLQKYKMQAEEAER 1477
Cdd:PRK04863   290 ELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDhlnlvqTALRQQEKIERYQADLEELEERLEEQNE 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1478 RMKQAEEEKIRQIRVVEEVAQ--KSAATQL----------QTKAMSFSEQTTKLEESLKKEQGNVL---KLQEEADKLKK 1542
Cdd:PRK04863   370 VVEEADEQQEENEARAEAAEEevDELKSQLadyqqaldvqQTRAIQYQQAVQALERAKQLCGLPDLtadNAEDWLEEFQA 449

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1543 QQKEANTAREEAEQEL----EIWRQ--KANEALRlRLQAE-EEAQKKSHAQE---EAEKQKLEAERDAKKRGKAEEaaLK 1612
Cdd:PRK04863   450 KEQEATEELLSLEQKLsvaqAAHSQfeQAYQLVR-KIAGEvSRSEAWDVAREllrRLREQRHLAEQLQQLRMRLSE--LE 526

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1613 QKENAEKELDKQRKFAEQIAQQKLSAEQEcirLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMD 1692
Cdd:PRK04863   527 QRLRQQQRAERLLAEFCKRLGKNLDDEDE---LEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAP 603

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1693 SLLQMKinaEKASMVNTEKSKQLLESEALkmkqlaDEAarMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEA 1772
Cdd:PRK04863   604 AWLAAQ---DALARLREQSGEEFEDSQDV------TEY--MQQLLERERELTVERDELAARKQALDEEIERLSQPGGSED 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1773 TRLKTEAEmalkakeaeneRLKRQAEEEAYQRKLLEDQA--------AQHK---QDIEEKITQLQT-------------- 1827
Cdd:PRK04863   673 PRLNALAE-----------RFGGVLLSEIYDDVSLEDAPyfsalygpARHAivvPDLSDAAEQLAGledcpedlyliegd 741

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1828 -------SSDSELGRQKNIVEETLKQ---KKVVEEEIhiikinFHKASKEK--ADLESElkklkgiADETQKSKLKAEEE 1895
Cdd:PRK04863   742 pdsfddsVFSVEELEKAVVVKIADRQwrySRFPEVPL------FGRAAREKriEQLRAE-------REELAERYATLSFD 808

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1896 AEKLKKLAAEEERRRKEAEEKVkrITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAekeaekqvvlAKEAAQKCTA 1975
Cdd:PRK04863   809 VQKLQRLHQAFSRFIGSHLAVA--FEADPEAELRQLNRRRVELERALADHESQEQQQRSQ----------LEQAKEGLSA 876

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1976 AEQKAQDVlsknkeDVLAQEKLRDEF----------ENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAEneaak 2045
Cdd:PRK04863   877 LNRLLPRL------NLLADETLADRVeeireqldeaEEAKRFVQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQ----- 945

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2046 QAKAQNDTEKQRK---------------EAEEEAARRAAAEAAALKQKQ-QADAEMSKHKKEAEQALQQKSQVEKELTvv 2109
Cdd:PRK04863   946 QAQQTQRDAKQQAfaltevvqrrahfsyEDAAEMLAKNSDLNEKLRQRLeQAEQERTRAREQLRQAQAQLAQYNQVLA-- 1023

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2110 KLQLDETDKQKVL--LDQELQRV-----KGEVNDAFKQKSQVEVELARVRIQMEELVKLKLKIEEE----NRRLMQKDKD 2178
Cdd:PRK04863  1024 SLKSSYDAKRQMLqeLKQELQDLgvpadSGAEERARARRDELHARLSANRSRRNQLEKQLTFCEAEmdnlTKKLRKLERD 1103

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 2179 STQ-KLLAEEAEKMKSLAEEAGRLSvEAEETARQRQIAESNLAEQRALAEKIL 2230
Cdd:PRK04863  1104 YHEmREQVVNAKAGWCAVLRLVKDN-GVERRLHRRELAYLSADELRSMSDKAL 1155
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 2213-2354 2.04e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2213 QIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLD------------KETE 2280
Cdd:COG1579     13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKkyeeqlgnvrnnKEYE 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2281 GFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQrTEKHTTEIVVQKLETQR 2354
Cdd:COG1579     93 ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD-EELAELEAELEELEAER 165
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 2075-2356 2.13e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 46.73  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2075 LKQKQQADAEMSKHKKEaeqalqqksqVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQ 2154
Cdd:pfam15905   61 LKKKSQKNLKESKDQKE----------LEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2155 MEELVK----LKLKIEEE-NRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKI 2229
Cdd:pfam15905  131 LLELTRvnelLKAKFSEDgTQKKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVST 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2230 LKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRlDKETEGFQKSLEAerkRQLEASAEAEKLKLRVKE 2309
Cdd:pfam15905  211 EKEKIEEKSETEKLLEYITELSCVSEQVEKYKLDIAQLEELLKEK-NDEIESLKQSLEE---KEQELSKQIKDLNEKCKL 286

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 2310 LslaQTKAEDEAKKFKKQADEVKAQLQRTEKhttEIVVQKLETQRLQ 2356
Cdd:pfam15905  287 L---ESEKEELLREYEEKEQTLNAELEELKE---KLTLEEQEHQKLQ 327
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 1453-1813 2.13e-04

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 47.33  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1453 EAAKQKQRALDDLQK----YKMQAEEAERRMKQAEEEKIRQIRVVEEvaqksaatqlqtkamsfseqttkLEESLKKEQG 1528
Cdd:pfam05701   35 ERRKLVELELEKVQEeipeYKKQSEAAEAAKAQVLEELESTKRLIEE-----------------------LKLNLERAQT 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1529 NVLKLQEEAD--KLKKQQKEANTAREE---AEQELEIWRQKANEALrlrlqAEEEAQKKSHAQEEAEKQKLEAERDAKKR 1603
Cdd:pfam05701   92 EEAQAKQDSElaKLRVEEMEQGIADEAsvaAKAQLEVAKARHAAAV-----AELKSVKEELESLRKEYASLVSERDIAIK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1604 gKAEEAALKQKE------------NAEKELDKQRKFAEQIAQQK-----LSAEQECIRLKADFEHAEQqrglldnELQRL 1666
Cdd:pfam05701  167 -RAEEAVSASKEiektveeltielIATKESLESAHAAHLEAEEHrigaaLAREQDKLNWEKELKQAEE-------ELQRL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1667 KNEVNSTEKQRKQLE---DELNKVRSEMDSLLQMKINAEKASMVNTEKS-----------KQLLESEALKMKQLADEAAR 1732
Cdd:pfam05701  239 NQQLLSAKDLKSKLEtasALLLDLKAELAAYMESKLKEEADGEGNEKKTstsiqaalasaKKELEEVKANIEKAKDEVNC 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1733 MRSVAE--EAKKQRQIAEEEAARQRSEAEKILKEKLAAinEATRLKTEAEMALKAKEAENERLKR------QAEEEAYQR 1804
Cdd:pfam05701  319 LRVAAAslRSELEKEKAELASLRQREGMASIAVSSLEA--ELNRTKSEIALVQAKEKEAREKMVElpkqlqQAAQEAEEA 396


                   ....*....
gi 1389908296 1805 KLLEdQAAQ 1813
Cdd:pfam05701  397 KSLA-QAAR 404
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2941-2976 2.17e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 41.16  E-value: 2.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1389908296 2941 LQGTPSIAGILDEPTKEKMPFYQAMKKEFLSPETAL 2976
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQ 37
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2039-2273 2.18e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2039 AENEAAKQAKAQNDTEKQRKeaeeeaarraaaeaAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDK 2118
Cdd:COG3883     14 ADPQIQAKQKELSELQAELE--------------AAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2119 QkvlLDQELQRVKGEVNDAFKQKSQVEVE------------LARVriqmeELVKlklKIEEENRRLMQKDKDSTQKLlae 2186
Cdd:COG3883     80 E---IEERREELGERARALYRSGGSVSYLdvllgsesfsdfLDRL-----SALS---KIADADADLLEELKADKAEL--- 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2187 eAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQE 2266
Cdd:COG3883    146 -EAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAA 224


                   ....*..
gi 1389908296 2267 DKQQIQQ 2273
Cdd:COG3883    225 AAAAAAA 231
PLEC smart00250
Plectin repeat;
3642-3675 2.19e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.31  E-value: 2.19e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  3642 LLEAQAATGFMIDPVKDELLTVDEAVRKGLVGPE 3675
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 2433-2515 2.19e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 46.42  E-value: 2.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2433 EKQLEDEMKKAKALkdeqERQRKLMEEERKKLQAIMDEAVRKQKEA--------EEEMKNKQREMD-VLDKKRLEQEKQL 2503
Cdd:cd16269    197 EKEIEAERAKAEAA----EQERKLLEEQQRELEQKLEDQERSYEEHlrqlkekmEEERENLLKEQErALESKLKEQEALL 272

                           90
                   ....*....|..
gi 1389908296 2504 AEENKKLREQLQ 2515
Cdd:cd16269    273 EEGFKEQAELLQ 284
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1367-1778 2.20e-04

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 47.59  E-value: 2.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1367 LEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRA-AEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELK 1445
Cdd:pfam15964  312 LMSALVSVRSSLAEAQQRESSAYEQVKQAVQMTEEANFEKTKAlIQCEQLKSELERQKERLEKELASQQEKRAQEKEALR 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1446 RKSDAEKEAAKQKQRALDDlqkykmQAEEAERRMKQAEEEKIRQIRVVEEvaqksAATQLQTKAMSFSEQTTKLEESLKK 1525
Cdd:pfam15964  392 KEMKKEREELGATMLALSQ------NVAQLEAQVEKVTREKNSLVSQLEE-----AQKQLASQEMDVTKVCGEMRYQLNQ 460

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1526 EQgnvLKLQEEADKLKKQQKEANTAREEAEQELEiwrqkanealRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGK 1605
Cdd:pfam15964  461 TK---MKKDEAEKEHREYRTKTGRQLEIKDQEIE----------KLGLELSESKQRLEQAQQDAARAREECLKLTELLGE 527

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1606 AEEAALKQKEnaEKElDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQ------ 1679
Cdd:pfam15964  528 SEHQLHLTRL--EKE-SIQQSFSNEAKAQALQAQQREQELTQKMQQMEAQHDKTVNEQYSLLTSQNTFIAKLKEecctla 604

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1680 --LEDELNKVRSEMDSLLQ----MKINAEKASMVNTEKSKQLLESEalKMKQladeaaRMRSVAEEAKKQRQIAEEEAAR 1753
Cdd:pfam15964  605 kkLEEITQKSRSEVEQLSQekeyLQDRLEKLQKRNEELEEQCVQHG--RMHE------RMKQRLRQLDKHCQATAQQLVQ 676

                          410       420
                   ....*....|....*....|....*
gi 1389908296 1754 QRSEAEKILKEKLAAINEATRLKTE 1778
Cdd:pfam15964  677 LLSKQNQLFKERQNLTEEVQSLRSQ 701
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1141-1584 2.23e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 2.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1141 DSYEWLIRWLTEARQRQEKIQAVpISDSRALREQLTDEKKLLG------EIEKNKDKIDDCHKNAKAYIDSVKDYEFQIL 1214
Cdd:COG4717     88 EEYAELQEELEELEEELEELEAE-LEELREELEKLEKLLQLLPlyqeleALEAELAELPERLEELEERLEELRELEEELE 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1215 TYKALQDPIASPLKKpKMECASDDIIQEYVNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEKASEKLKEEERRkmAEIQA 1294
Cdd:COG4717    167 ELEAELAELQEELEE-LLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEA--AALEE 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1295 ELDKQKQMAEAHAksvakaeqEALELKMKMKEEASKRQDVAADAekqkQNIQQELQHLKSLSDQEIKSKNQQLEDALVSR 1374
Cdd:COG4717    244 RLKEARLLLLIAA--------ALLALLGLGGSLLSLILTIAGVL----FLVLGLLALLFLLLAREKASLGKEAEELQALP 311

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1375 RKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKnaedeLKRKSDAEKEA 1454
Cdd:COG4717    312 ALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAL-----LAEAGVEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1455 AKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQgNVLKLQ 1534
Cdd:COG4717    387 LRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELE-AELEQL 465

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1535 EEADKLKKQQKEANTAREEAEQELEIWRqkaneALRLRLQAEEEAQKKSH 1584
Cdd:COG4717    466 EEDGELAELLQELEELKAELRELAEEWA-----ALKLALELLEEAREEYR 510
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1520-1690 2.31e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 47.25  E-value: 2.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQA-------EEEAQKKSHAQEEAEKQ 1592
Cdd:pfam15709  340 AERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRleeerqrQEEEERKQRLQLQAAQE 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1593 KLEAERDAKKRGKAEEAALKQKENAEK-ELDKQRKFAEQIaqqKLSAEQecirlKADFEHAEQQRglldNELQRLKNEvn 1671
Cdd:pfam15709  420 RARQQQEEFRRKLQELQRKKQQEEAERaEAEKQRQKELEM---QLAEEQ-----KRLMEMAEEER----LEYQRQKQE-- 485

                          170
                   ....*....|....*....
gi 1389908296 1672 stEKQRKQLEDELNKVRSE 1690
Cdd:pfam15709  486 --AEEKARLEAEERRQKEE 502
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 1720-1949 2.33e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 47.25  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1720 ALKMKQLADEAARMRSvaeEAKKQRQIAEEEA--ARQRSEAEKILKEKLAAINEA-TRLK-----------TEAEMALKA 1785
Cdd:PRK05035   440 AIEQEKKKAEEAKARF---EARQARLEREKAAreARHKKAAEARAAKDKDAVAAAlARVKakkaaatqpivIKAGARPDN 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1786 KEAENERLKRQAEEEAYQRKLLEDQAAQHKQD-IEEKITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINfhKA 1864
Cdd:PRK05035   517 SAVIAAREARKAQARARQAEKQAAAAADPKKAaVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAK--KA 594

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1865 SKEKADLESELKKLkgiADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKK 1944
Cdd:PRK05035   595 AQQAASAEPEEQVA---EVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAKARKAAQQQANAEPEE 671


                   ....*
gi 1389908296 1945 AEDAN 1949
Cdd:PRK05035   672 AEDPK 676
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1417-1835 2.44e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 47.49  E-value: 2.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1417 KAAQDEAERLRKQVA-----EETQRKKnAEDELKRKSDAEKEAAKQKQRA---------LDDLQKYKMQAEEAERRMKQA 1482
Cdd:PRK10246   194 KSARTELEKLQAQASgvallTPEQVQS-LTASLQVLTDEEKQLLTAQQQQqqslnwltrLDELQQEASRRQQALQQALAA 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1483 EEEKIRQIRVVEeVAQksAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWR 1562
Cdd:PRK10246   273 EEKAQPQLAALS-LAQ--PARQLRPHWERIQEQSAALAHTRQQIEEVNTRLQSTMALRARIRHHAAKQSAELQAQQQSLN 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1563 QKANEALRLRLQAEEEA--------QKKSHAQEE-------AEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQR-- 1625
Cdd:PRK10246   350 TWLAEHDRFRQWNNELAgwraqfsqQTSDREQLRqwqqqltHAEQKLNALPAITLTLTADEVAAALAQHAEQRPLRQRlv 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1626 ----------KFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNeVNSTEKQRKQLEDELNKVRSEMDSLL 1695
Cdd:PRK10246   430 alhgqivpqqKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKT-ICEQEARIKDLEAQRAQLQAGQPCPL 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1696 -----QMKINAEKASMVNTEKSKQL-LESEalkMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEaEKILKEKLAAI 1769
Cdd:PRK10246   509 cgstsHPAVEAYQALEPGVNQSRLDaLEKE---VKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQE-EQALTQQWQAV 584

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1770 NEATRLKTEAEMALKAKEAENERLKRQAEEEAyQRKLLEDQAAQHKQDI---EEKITQLQTSSDSELGR 1835
Cdd:PRK10246   585 CASLNITLQPQDDIQPWLDAQEEHERQLRLLS-QRHELQGQIAAHNQQIiqyQQQIEQRQQQLLTALAG 652
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1539-1901 2.45e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.82  E-value: 2.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1539 KLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAE 1618
Cdd:COG4372      7 KVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELN 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1619 KELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLK-------NEVNSTEKQRKQLEDELNKVRSEM 1691
Cdd:COG4372     87 EQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEaqiaelqSEIAEREEELKELEEQLESLQEEL 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1692 DSLLQMKINAEKASMVNtekskqllesealKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINE 1771
Cdd:COG4372    167 AALEQELQALSEAEAEQ-------------ALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGL 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1772 ATRLKTEAEMALKAKEAENERLK-RQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQKKVV 1850
Cdd:COG4372    234 ALSALLDALELEEDKEELLEEVIlKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGAL 313

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1851 EEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKK 1901
Cdd:COG4372    314 EDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAE 364
PLEC smart00250
Plectin repeat;
2652-2685 2.53e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 2.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  2652 LLEAQAASGFIVDPVKNKFLSVDEAVKDKVIGPE 2685
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 2091-2409 2.58e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 47.64  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2091 EAEQALQQKSQVEKELTvvkLQLDETDKQKVLLDQELQRVKGEVNDAfkqkSQVEVELARVRIQMEELVKLKlkieEENR 2170
Cdd:COG3096    358 ELTERLEEQEEVVEEAA---EQLAEAEARLEAAEEEVDSLKSQLADY----QQALDVQQTRAIQYQQAVQAL----EKAR 426

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2171 RLMQKDkDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKE--KMQAIQEATKLKAEAE 2248
Cdd:COG3096    427 ALCGLP-DLTPENAEDYLAAFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELVCKIAGEveRSQAWQTARELLRRYR 505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2249 KLQKQKDQAQETAKRLQEDKQQI--QQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKK 2326
Cdd:COG3096    506 SQQALAQRLQQLRAQLAELEQRLrqQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQ 585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QADEVKAQLQRTEK-----HTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKeaeelqrkSKEMANAQQEQIE 2401
Cdd:COG3096    586 QLEQLRARIKELAArapawLAAQDALERLREQSGEALADSQEVTAAMQQLLEREREATV--------ERDELAARKQALE 657


                   ....*...
gi 1389908296 2402 QQKAELQQ 2409
Cdd:COG3096    658 SQIERLSQ 665
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 1532-1639 2.63e-04

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 44.39  E-value: 2.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1532 KLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALrlrlqaeEEAQKKSHAQEEAEKQKLEAERDAKKRgKAEEAAL 1611
Cdd:COG0711     35 KIADGLAEAERAKEEAEAALAEYEEKLAEARAEAAEII-------AEARKEAEAIAEEAKAEAEAEAERIIA-QAEAEIE 106

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1389908296 1612 KQKENAEKELDKQ-----RKFAEQIAQQKLSAE 1639
Cdd:COG0711    107 QERAKALAELRAEvadlaVAIAEKILGKELDAA 139
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1424-1609 2.64e-04

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 46.92  E-value: 2.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1424 ERLRKQVAEETQRKKNAEDELKRKSdaeKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEvAQKSAAT 1503
Cdd:pfam05262  184 EALREDNEKGVNFRRDMTDLKERES---QEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQ-KQQEAKN 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1504 QLQTKAMSFSEQTTKLEESLKKEqgnVLKLQEEAdklkkqQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKS 1583
Cdd:pfam05262  260 LPKPADTSSPKEDKQVAENQKRE---IEKAQIEI------KKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKR 330

                          170       180
                   ....*....|....*....|....*.
gi 1389908296 1584 HAQEEaEKQKLEAERDAKKRGKAEEA 1609
Cdd:pfam05262  331 EPVAE-DLQKTKPQVEAQPTSLNEDA 355
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1312-1816 2.81e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 47.49  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1312 KAEQEALElkmKMKEEASkrqDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKT 1391
Cdd:PRK10246   194 KSARTELE---KLQAQAS---GVALLTPEQVQSLTASLQVLTDEEKQLLTAQQQQQQSLNWLTRLDELQQEASRRQQALQ 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1392 TAHKAKSEAELQELRDRAAE-AEKLRKAaqdeAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDdlQKYKM 1470
Cdd:PRK10246   268 QALAAEEKAQPQLAALSLAQpARQLRPH----WERIQEQSAALAHTRQQIEEVNTRLQSTMALRARIRHHAAK--QSAEL 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1471 QAEEAERRMKQAEEEKIRQIRvvEEVA--------QKSAATQLQTKAMSFSEQTTKL-------------EESLKKEQGN 1529
Cdd:PRK10246   342 QAQQQSLNTWLAEHDRFRQWN--NELAgwraqfsqQTSDREQLRQWQQQLTHAEQKLnalpaitltltadEVAAALAQHA 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1530 --------VLKLQEEADKLKKQQKEANTAREEAEQELeiwrQKANEALRLRLQ-----AEEEAQKKSHAQEEAEKQKLEA 1596
Cdd:PRK10246   420 eqrplrqrLVALHGQIVPQQKRLAQLQVAIQNVTQEQ----TQRNAALNEMRQrykekTQQLADVKTICEQEARIKDLEA 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1597 ERDAKKRGK-------AEEAALKQKENAEKELDKQRKfaEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNE 1669
Cdd:PRK10246   496 QRAQLQAGQpcplcgsTSHPAVEAYQALEPGVNQSRL--DALEKEVKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQE 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1670 VNSTEKQRKQLEDELNKVRSEMDSL----------------------LQMKINAEKASMVN----TEKSKQLLESE---- 1719
Cdd:PRK10246   574 EQALTQQWQAVCASLNITLQPQDDIqpwldaqeeherqlrllsqrheLQGQIAAHNQQIIQyqqqIEQRQQQLLTAlagy 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1720 ALKMKQLADEAARMRSVAEEAKK-QRQIAEEEAARQRSEAEKILKEKLAAINEATrlkTEAEMAL--KAKEAENERLKRQ 1796
Cdd:PRK10246   654 ALTLPQEDEEASWLATRQQEAQSwQQRQNELTALQNRIQQLTPLLETLPQSDDLP---HSEETVAldNWRQVHEQCLSLH 730

                          570       580
                   ....*....|....*....|.
gi 1389908296 1797 AEEEAYQRKL-LEDQAAQHKQ 1816
Cdd:PRK10246   731 SQLQTLQQQDvLEAQRLQKAQ 751
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1879-2103 2.85e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 46.72  E-value: 2.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1879 KGIADETQKSKLKAEEEAEKLKklaaeeerrrkeaeekvkritaaEEEAARQCKAAQEEVERL-----KKKAEDANKQKE 1953
Cdd:PRK09510    72 KSAKRAEEQRKKKEQQQAEELQ-----------------------QKQAAEQERLKQLEKERLaaqeqKKQAEEAAKQAA 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1954 KAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEdvlAQEKLRDEFENAKKLAQEAEKAKEKAEKEaallRQKAEEAE 2033
Cdd:PRK09510   129 LKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKAA---AEAKKKAEAEAAKKAAAEAKKKAEAEAAA----KAAAEAKK 201

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2034 KQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAaeaaalkqkqqADAEMSKHKKEAEQALQQKSQVE 2103
Cdd:PRK09510   202 KAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAA-----------AEKAAAAKAAEKAAAAKAAAEVD 260
mukB PRK04863
chromosome partition protein MukB;
2091-2364 2.92e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.26  E-value: 2.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2091 EAEQALQQKSQVEKEltvVKLQLDETDKQKVLLDQELQRVKGEVND-------------AFKQKSQVeVELARVRIQMEE 2157
Cdd:PRK04863   359 ELEERLEEQNEVVEE---ADEQQEENEARAEAAEEEVDELKSQLADyqqaldvqqtraiQYQQAVQA-LERAKQLCGLPD 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2158 LV--KLKLKIEEenrrLMQKDKDSTQKLLAEE-----AEKMKSLAEEAGRL------SVEAEETARQRQIAESNLAEQRA 2224
Cdd:PRK04863   435 LTadNAEDWLEE----FQAKEQEATEELLSLEqklsvAQAAHSQFEQAYQLvrkiagEVSRSEAWDVARELLRRLREQRH 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2225 LAEKI--LKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEK 2302
Cdd:PRK04863   511 LAEQLqqLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQ 590

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2303 LKLRVKEL------------SLAQTKAEDEAKKFKKQA-DEVKAQLQRTEKHTTEiVVQKLETQRLQSTREADDL 2364
Cdd:PRK04863   591 LQARIQRLaarapawlaaqdALARLREQSGEEFEDSQDvTEYMQQLLERERELTV-ERDELAARKQALDEEIERL 664
PLEC smart00250
Plectin repeat;
3716-3752 2.97e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 2.97e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  3716 LRLLEAQNATGGYMDPEYYFRLPIDVAMQRGYINKET 3752
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1325-1556 2.97e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 46.38  E-value: 2.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1325 KEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDAlvSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQE 1404
Cdd:TIGR02794   49 AQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKEL--EQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1405 lrdrAAEAEKLRKAaqdEAERLRKQvAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKykmqAEEAERRmKQAEE 1484
Cdd:TIGR02794  127 ----KQAAEAKAKA---EAEAERKA-KEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKA----KAEAEAK-AKAEE 193

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1485 EKIRQirvveEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQE-EADKLKKQQKEANTAREEAEQ 1556
Cdd:TIGR02794  194 AKAKA-----EAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGlASGSNAEKQGGARGAAAGSEV 261
PTZ00491 PTZ00491
major vault protein; Provisional
 1541-1694 3.01e-04

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 47.32  E-value: 3.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1541 KKQQKEANTAREEAEQE----LEiwRQKanealrLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKEN 1616
Cdd:PTZ00491   662 KSQEAAARHQAELLEQEargrLE--RQK------MHDKAKAEEQRTKLLELQAESAAVESSGQSRAEALAEAEARLIEAE 733

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1617 AEKELDKQRKFAEQIAQQklsAEQECIRLKADFEHAEQQRgllDNELQRlknevnstEKQRKQLEDELNKVRSEMDSL 1694
Cdd:PTZ00491   734 AEVEQAELRAKALRIEAE---AELEKLRKRQELELEYEQA---QNELEI--------AKAKELADIEATKFERIVEAL 797
Caldesmon pfam02029
Caldesmon;
1552-1902 3.02e-04

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 46.78  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1552 EEAEQELeiwRQKANEAlRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKK----RGKAEEAALKQKEnAEKELDKQRKF 1627
Cdd:pfam02029    5 EEAARER---RRRAREE-RRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKpsgqGGLDEEEAFLDRT-AKREERRQKRL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1628 AEQIAQQKlsaeqecirlkadfehaeqqrgLLDNELQRLKNEVNStEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMV 1707
Cdd:pfam02029   80 QEALERQK----------------------EFDPTIADEKESVAE-RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIR 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1708 NTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRqIAEEEAARQRSEAEKILKEKLAAINEATRLKTEA------EM 1781
Cdd:pfam02029  137 EKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTEN-FAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVksqngeEE 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1782 ALKAKEAENERLK-----RQAEEEAYQR----KLLEDQAAQHkQDIE----EKITQLQTSSDSELGRQKNIVEEtlkQKK 1848
Cdd:pfam02029  216 VTKLKVTTKRRQGglsqsQEREEEAEVFleaeQKLEELRRRR-QEKEseefEKLRQKQQEAELELEELKKKREE---RRK 291

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1849 VVEEEihiikinfhkasKEKADLESELKKLKGiadETQKSKLKAE------EEAEKLKKL 1902
Cdd:pfam02029  292 LLEEE------------EQRRKQEEAERKLRE---EEEKRRMKEEierrraEAAEKRQKL 336
PLEC smart00250
Plectin repeat;
3309-3342 3.06e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 3.06e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1389908296  3309 LLEAQAATGFITDPVKDKKCSVDDAVKEGIVGPE 3342
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1715-1949 3.07e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 3.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1715 LLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLK 1794
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1795 RQAEEeayqrklLEDQAAQHKQDIEEKITQLQTSSDSE----LGRQKNIVE-----ETLKQ-KKVVEEEIHIIKINFHKA 1864
Cdd:COG4942     90 KEIAE-------LRAELEAQKEELAELLRALYRLGRQPplalLLSPEDFLDavrrlQYLKYlAPARREQAEELRADLAEL 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1865 SKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKK 1944
Cdd:COG4942    163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242


                   ....*
gi 1389908296 1945 AEDAN 1949
Cdd:COG4942    243 TPAAG 247
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 1268-1501 3.24e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 46.86  E-value: 3.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1268 QRRLEDdekasEKLKEEERRKMAEiqAELDKQKQMAEAHAKSVAKAEQEALELKMKMK-EEASKRQDVAADAEKQKQNIQ 1346
Cdd:PRK05035   459 QARLER-----EKAAREARHKKAA--EARAAKDKDAVAAALARVKAKKAAATQPIVIKaGARPDNSAVIAAREARKAQAR 531

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1347 QELQhlKSLSDQEIKSKNQQLEDALV-SRRKIEEEIHIIRIQLEKTTAHKAKSEAELqelrdraAEAeKLRKAAQDEAER 1425
Cdd:PRK05035   532 ARQA--EKQAAAAADPKKAAVAAAIArAKAKKAAQQAANAEAEEEVDPKKAAVAAAI-------ARA-KAKKAAQQAASA 601

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1426 LRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALD--DLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSA 1501
Cdd:PRK05035   602 EPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEpvDPRKAAVAAAIARAKARKAAQQQANAEPEEAEDPKKAA 679
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
2076-2326 3.36e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.06  E-value: 3.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2076 KQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQK---SQVEVELARVR 2152
Cdd:COG1340     43 EKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELRKELAELNKAGgsiDKLRKEIERLE 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2153 IQMEELVklkLKIEEEnRRLMQKDKDSTQKLlaEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKE 2232
Cdd:COG1340    123 WRQQTEV---LSPEEE-KELVEKIKELEKEL--EKAKKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEE 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2233 KMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKetegFQKSLEAERKRQLEASaeaeklklRVKELSL 2312
Cdd:COG1340    197 MIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQKELRE----LRKELKKLRKKQRALK--------REKEKEE 264

                          250
                   ....*....|....
gi 1389908296 2313 AQTKAEDEAKKFKK 2326
Cdd:COG1340    265 LEEKAEEIFEKLKK 278
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 2034-2300 3.65e-04

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 47.14  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2034 KQKKAAENEAAKQAKAQNDteKQRkeaeeeaarraaaeaaaLKQ-KQQADAEMSKHKKEAE----QALQQKSQVEKEltV 2108
Cdd:NF012221  1552 KQDDAAQNALADKERAEAD--RQR-----------------LEQeKQQQLAAISGSQSQLEstdqNALETNGQAQRD--A 1610

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2109 VKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELA---RVRIQmEELVKLKLKIEEENRRLMQKDKDSTQKLla 2185
Cdd:NF012221  1611 ILEESRAVTKELTTLAQGLDALDSQATYAGESGDQWRNPFAgglLDRVQ-EQLDDAKKISGKQLADAKQRHVDNQQKV-- 1687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2186 eeaekMKSLAE-EAGrlsveAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLK----AEAEKLQKQKDQAQET 2260
Cdd:NF012221  1688 -----KDAVAKsEAG-----VAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAEsdanAAANDAQSRGEQDASA 1757

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1389908296 2261 AK----RLQEDKQQIQQRLDK--ETEGFQKSLEAERKRQLEASAEA 2300
Cdd:NF012221  1758 AEnkanQAQADAKGAKQDESDkpNRQGAAGSGLSGKAYSVEGVAEP 1803
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 1267-1525 4.01e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 45.90  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1267 AQRRLEDDEKASEKLKE----EERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMkeeaskrQDVAADAEKQK 1342
Cdd:pfam09787   16 AARILQSKEKLIASLKEgsgvEGLDSSTALTLELEELRQERDLLREEIQKLRGQIQQLRTEL-------QELEAQQQEEA 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSlsDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTahkakseaeLQE-LRDRAAEAEKlrkaaqd 1421
Cdd:pfam09787   89 ESSREQLQELEE--QLATERSARREAEAELERLQEELRYLEEELRRSKAT---------LQSrIKDREAEIEK------- 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1422 eaerLRKQVAEETQrKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYK----MQAEEAERRMKQAEEEKIRQIRVVEEVA 1497
Cdd:pfam09787  151 ----LRNQLTSKSQ-SSSSQSELENRLHQLTETLIQKQTMLEALSTEKnslvLQLERMEQQIKELQGEGSNGTSINMEGI 225

                          250       260
                   ....*....|....*....|....*...
gi 1389908296 1498 QKSAATQLQTKAMSFSEQTTKLEESLKK 1525
Cdd:pfam09787  226 SDGEGTRLRNVPGLFSESDSDRAGMYGK 253
PRK12704 PRK12704
phosphodiesterase; Provisional
 2212-2361 4.03e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.31  E-value: 4.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2212 RQIAESNLAEQRALAEKILKE---KMQAIQEATKLKAEaEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEA 2288
Cdd:PRK12704    26 KKIAEAKIKEAEEEAKRILEEakkEAEAIKKEALLEAK-EEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLEL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2289 ERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQ--------ADEVKAQ-LQRTE---KHTTEIVVQKLETQ-RL 2355
Cdd:PRK12704   105 LEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQElerisgltAEEAKEIlLEKVEeeaRHEAAVLIKEIEEEaKE 184


                   ....*.
gi 1389908296 2356 QSTREA 2361
Cdd:PRK12704   185 EADKKA 190
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1743-2426 4.18e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 46.76  E-value: 4.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1743 QRQIAEEEAARQrsEAEKILKEKLAA--------INEATRLKTEAEMALKAKEAENERLKRQA----EEEAYQRKLLEDQ 1810
Cdd:pfam12128  271 ETLIASRQEERQ--ETSAELNQLLRTlddqwkekRDELNGELSAADAAVAKDRSELEALEDQHgaflDADIETAAADQEQ 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1811 AAQHKQDIE--EKITQLQTSSDSEL-----GRQKNIVEETLKQKKVVEEEIHIIKinfHKASKEKADLESELKKLKG-IA 1882
Cdd:pfam12128  349 LPSWQSELEnlEERLKALTGKHQDVtakynRRRSKIKEQNNRDIAGIKDKLAKIR---EARDRQLAVAEDDLQALESeLR 425

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1883 DETQKSKLKAEEEAEKLKklaaeeeRRRKEAEEKVKRITAAEEEAARQcKAAQEEVERLKKKAEDANKQKEkaekeaekq 1962
Cdd:pfam12128  426 EQLEAGKLEFNEEEYRLK-------SRLGELKLRLNQATATPELLLQL-ENFDERIERAREEQEAANAEVE--------- 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1963 vvlakeAAQKctaaEQKAQDVLSKNKEDVLAQEKLRDEfENAKKLAQEAEKAKEKAEKEAALLRQkaeEAEKQKKAAENE 2042
Cdd:pfam12128  489 ------RLQS----ELRQARKRRDQASEALRQASRRLE-ERQSALDELELQLFPQAGTLLHFLRK---EAPDWEQSIGKV 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2043 AAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSkhkkeaEQALQQK-SQVEKELTVVKLQLDETDKQKV 2121
Cdd:pfam12128  555 ISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAAS------EEELRERlDKAEEALQSAREKQAAAEEQLV 628

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2122 LLDQELQRVKGEVNDAFKQKSQVEVELARVRIQMEElvkLKLKIEEENRRLMQKDKDSTQKLLAE----EAEKMKSLAEE 2197
Cdd:pfam12128  629 QANGELEKASREETFARTALKNARLDLRRLFDEKQS---EKDKKNKALAERKDSANERLNSLEAQlkqlDKKHQAWLEEQ 705

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2198 AGRLSVEAEETARQRQIAESNLAEQRA-LAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLD 2276
Cdd:pfam12128  706 KEQKREARTEKQAYWQVVEGALDAQLAlLKAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIE 785

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2277 KETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRtEKHTTEivvqKLETQRLQ 2356
Cdd:pfam12128  786 RIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEM-ERKASE----KQQVRLSE 860

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2357 STREADDLKSAIADLeeerkklkkeaeelqrksKEMANAQQEQ--IEQQKAELQQSFLTEKGLLLKREKEVE 2426
Cdd:pfam12128  861 NLRGLRCEMSKLATL------------------KEDANSEQAQgsIGERLAQLEDLKLKRDYLSESVKKYVE 914
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 2182-2507 4.26e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.87  E-value: 4.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2182 KLLAEEAEkmkSLAEEAGRLSVEAEETARQRQIAESNLAEQRALA-----EKILKEKMQAIQEATK-LKAEAEKLQKQKD 2255
Cdd:COG3096    788 EELRAERD---ELAEQYAKASFDVQKLQRLHQAFSQFVGGHLAVAfapdpEAELAALRQRRSELEReLAQHRAQEQQLRQ 864

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2256 QAQETAKRLQE-----------DKQQIQQRLDKETEGFQKSLEAER--KRQLEASAEAEKL--KLRVKELSLAQTKAEDE 2320
Cdd:COG3096    865 QLDQLKEQLQLlnkllpqanllADETLADRLEELREELDAAQEAQAfiQQHGKALAQLEPLvaVLQSDPEQFEQLQADYL 944

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2321 akkfkkQADEVKAQLQRTEKHTTEIVvqkletQRLQ--STREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQE 2398
Cdd:COG3096    945 ------QAKEQQRRLKQQIFALSEVV------QRRPhfSYEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAQA 1012

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2399 QIEQQKAELQQ---SFLTEKGLLlkreKEVEGEKKRFEKQLEDEMK-KAKALKDE------QERQRK-LMEEERKKLQAI 2467
Cdd:COG3096   1013 QYSQYNQVLASlksSRDAKQQTL----QELEQELEELGVQADAEAEeRARIRRDElheelsQNRSRRsQLEKQLTRCEAE 1088

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1389908296 2468 MDEAVRKQKEAEEEMKNkQREMDVLDKKRLEQEKQLAEEN 2507
Cdd:COG3096   1089 MDSLQKRLRKAERDYKQ-EREQVVQAKAGWCAVLRLARDN 1127
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2200-2514 4.30e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 4.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2200 RLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKEt 2279
Cdd:COG4372     14 SLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAA- 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2280 egfQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVVQKLETQRLQSTR 2359
Cdd:COG4372     93 ---QAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAAL 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2360 EADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDE 2439
Cdd:COG4372    170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2440 MKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQL 2514
Cdd:COG4372    250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLEL 324
PRK12705 PRK12705
hypothetical protein; Provisional
 2075-2241 4.53e-04

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 46.24  E-value: 4.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2075 LKQKQQADAEMSKHKKEA-EQALQQKSQVEKELTVVKLQLDETDKQKVLLD-QELQRvkgEVNDAFKQKSQVEVELARVR 2152
Cdd:PRK12705    25 LKKRQRLAKEAERILQEAqKEAEEKLEAALLEAKELLLRERNQQRQEARRErEELQR---EEERLVQKEEQLDARAEKLD 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2153 IQMEELVKLKLKIEEENRRLMQKDKDSTQKLlaEEAEKMKS---LAEEAGRLSVEAEETARQR--QIAESNLAEQRALAE 2227
Cdd:PRK12705   102 NLENQLEEREKALSARELELEELEKQLDNEL--YRVAGLTPeqaRKLLLKLLDAELEEEKAQRvkKIEEEADLEAERKAQ 179

                          170
                   ....*....|....
gi 1389908296 2228 KILKEKMQAIQEAT 2241
Cdd:PRK12705   180 NILAQAMQRIASET 193
PLEC smart00250
Plectin repeat;
2941-2975 4.57e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.54  E-value: 4.57e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1389908296  2941 LQGTPSIAGILDEPTKEKMPFYQAMKKEFLSPETA 2975
Cdd:smart00250    4 LEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1268-1865 4.76e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.48  E-value: 4.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1268 QRRLEDDEKASEKLKEEErrkmaEIQAELDKQKQMAEAHAKSvakAEQEALELKMKMK--EEASKRQDVAADAEKQKQNI 1345
Cdd:COG3096    350 ERYQEDLEELTERLEEQE-----EVVEEAAEQLAEAEARLEA---AEEEVDSLKSQLAdyQQALDVQQTRAIQYQQAVQA 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1346 QQELQHLKSLSD----------QEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEK--------------TTAHKAKSE-- 1399
Cdd:COG3096    422 LEKARALCGLPDltpenaedylAAFRAKEQQATEEVLELEQKLSVADAARRQFEKayelvckiageverSQAWQTAREll 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1400 ----------AELQELRDRAAEAEKlRKAAQDEAERLRKQVAEETQRKKNAEDELkrksDAEKEAAKQKQRALDDLQkyk 1469
Cdd:COG3096    502 rryrsqqalaQRLQQLRAQLAELEQ-RLRQQQNAERLLEEFCQRIGQQLDAAEEL----EELLAELEAQLEELEEQA--- 573

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1470 mqAEEAERRMK-QAEEEKIRQiRVVEEVAQKSAATQLQTKAMSFSEQTtklEESLKKEQGNVLKLQEEADKLKKQQKEAN 1548
Cdd:COG3096    574 --AEAVEQRSElRQQLEQLRA-RIKELAARAPAWLAAQDALERLREQS---GEALADSQEVTAAMQQLLEREREATVERD 647

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1549 TAREEAEQ-ELEIWRQKA---NEALRLRLQAE----------------EEAQKKS-------HA----QEEAEKQKLEA- 1596
Cdd:COG3096    648 ELAARKQAlESQIERLSQpggAEDPRLLALAErlggvllseiyddvtlEDAPYFSalygparHAivvpDLSAVKEQLAGl 727

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1597 ----------ERD----------AKKRGKAEEAALKQKE---------------NAEKELDKQRKFAEQIAQQ--KLSAE 1639
Cdd:COG3096    728 edcpedlyliEGDpdsfddsvfdAEELEDAVVVKLSDRQwrysrfpevplfgraAREKRLEELRAERDELAEQyaKASFD 807

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1640 -QECIRLKADFEH--------------------AEQQRglldNELQRLKNEVNSTEKQRKQ------------------- 1679
Cdd:COG3096    808 vQKLQRLHQAFSQfvgghlavafapdpeaelaaLRQRR----SELERELAQHRAQEQQLRQqldqlkeqlqllnkllpqa 883

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1680 -------LEDELNKVRSEMDSLLQ----MKINAEKASMVntEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQ----- 1743
Cdd:COG3096    884 nlladetLADRLEELREELDAAQEaqafIQQHGKALAQL--EPLVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQifals 961

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1744 ---------------RQIAE------------EEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAK-----EAENE 1791
Cdd:COG3096    962 evvqrrphfsyedavGLLGEnsdlneklrarlEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKqqtlqELEQE 1041

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1792 --RLKRQAEEEAyqrkllEDQAAQHKQDIEEKITQLQ---TSSDSELGRQKNIVEETLKQKKVVEEEIHIIK--INFHKA 1864
Cdd:COG3096   1042 leELGVQADAEA------EERARIRRDELHEELSQNRsrrSQLEKQLTRCEAEMDSLQKRLRKAERDYKQEReqVVQAKA 1115


                   .
gi 1389908296 1865 S 1865
Cdd:COG3096   1116 G 1116
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1525-2105 4.79e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.45  E-value: 4.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1525 KEQGNVLK-LQEEADKLKKQQKEANTARE--------EAEQELEIWRQK--ANEALRLRLQAEEEAQKKSHAQEEAEKQK 1593
Cdd:COG4913    248 REQIELLEpIRELAERYAAARERLAELEYlraalrlwFAQRRLELLEAEleELRAELARLEAELERLEARLDALREELDE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1594 LEAERDAKKrGKAEEAALKQKENAEKELDKQR----KFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNE 1669
Cdd:COG4913    328 LEAQIRGNG-GDRLEQLEREIERLERELEERErrraRLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEA 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1670 VNSTEKQRKQLEDELNKVRSEMDSLlqmkinaekasmvntEKSKQLLESEALKM-KQLADE----AARMRSVAEEAkkqr 1744
Cdd:COG4913    407 LAEAEAALRDLRRELRELEAEIASL---------------ERRKSNIPARLLALrDALAEAlgldEAELPFVGELI---- 467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1745 QIAEEEAARQRSeAEKILKeklaaiNEATRLKTEAEMALKAKEA-ENERLKRQ-------AEEEAYQRKLLEDQAAQHKQ 1816
Cdd:COG4913    468 EVRPEEERWRGA-IERVLG------GFALTLLVPPEHYAAALRWvNRLHLRGRlvyervrTGLPDPERPRLDPDSLAGKL 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1817 DIEEkiTQLQTSSDSELGRQKNIV----EETLKQ-KKVVEEEIHIikinfhKASKEKADleselkklKGIADETQKSKLK 1891
Cdd:COG4913    541 DFKP--HPFRAWLEAELGRRFDYVcvdsPEELRRhPRAITRAGQV------KGNGTRHE--------KDDRRRIRSRYVL 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1892 AEEEAEKLKKLAAEeerrrkeaeekVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEaekqvVLAKEAAQ 1971
Cdd:COG4913    605 GFDNRAKLAALEAE-----------LAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDE-----IDVASAER 668

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1972 KCTAAEQKAQDvLSKNKEDVLAQEKLRDEfenakklaqeaekakekaekeaalLRQKAEEAEKQKKAAENEAAKQAKAQN 2051
Cdd:COG4913    669 EIAELEAELER-LDASSDDLAALEEQLEE------------------------LEAELEELEEELDELKGEIGRLEKELE 723

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 2052 DTEKQRKEAEEEAARRAAAEAAALKQ---KQQADAEMSKHKKEAEQALQQKSQVEKE 2105
Cdd:COG4913    724 QAEEELDELQDRLEAAEDLARLELRAlleERFAAALGDAVERELRENLEERIDALRA 780
PLEC smart00250
Plectin repeat;
2726-2762 4.85e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 4.85e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1389908296  2726 TKFLDVQLATGGIIDPVNSHRVPLQTAYSQGQFDADM 2762
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1247-1641 4.85e-04

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 46.05  E-value: 4.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1247 RTRYSELMTLTNQYIKF---IIDAQRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMK 1323
Cdd:COG5278    106 QARLDELEALIDQWLAEleqVIALRRAGGLEAALALVRSGEGKALMDEIRARLLLLALALAALLLAAAALLLLLLALAAL 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1324 MKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQ 1403
Cdd:COG5278    186 LALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALALLLAALLLALLAALALAALLAA 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1404 ELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAE 1483
Cdd:COG5278    266 ALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAAALAALLALALATALAAAAAALA 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1484 EEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESlkkEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQ 1563
Cdd:COG5278    346 LLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGA---AEAVELEVLAIAAAAAAAAAEAAAAAAAAAAASAAEAL 422

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1564 KANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQE 1641
Cdd:COG5278    423 ELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAALAAAAAALAEAEAAAALAAAAALS 500
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1710-1940 5.19e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.61  E-value: 5.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1710 EKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAe 1789
Cdd:TIGR02794   69 RQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEE- 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1790 nerLKRQAEEEAyqrKLLEDQAAQHKQDIEEKITqlqtssdselgrqknivEETLKQKKVVEEeihiikinfhKASKEKA 1869
Cdd:TIGR02794  148 ---AAKQAEEEA---KAKAAAEAKKKAEEAKKKA-----------------EAEAKAKAEAEA----------KAKAEEA 194

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1870 DLESELKKLKGIADetqksklkAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEE--AARQCKAAQEEVER 1940
Cdd:TIGR02794  195 KAKAEAAKAKAAAE--------AAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGsnAEKQGGARGAAAGS 259
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1255-1531 5.46e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1255 TLTNQYIKFIIDAQRrlEDDEKASEKLKEEerrkMAEIQAELDKqkqmaeahaksvakAEQEALELKMKMKEEASKRQdv 1334
Cdd:COG3206    156 ALAEAYLEQNLELRR--EEARKALEFLEEQ----LPELRKELEE--------------AEAALEEFRQKNGLVDLSEE-- 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1335 AADAEKQKQNIQQELQHLKSLSdQEIKSKNQQLEDALvSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEK 1414
Cdd:COG3206    214 AKLLLQQLSELESQLAEARAEL-AEAEARLAALRAQL-GSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHP 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1415 LRKAAQDEAERLRKQVAEETQRkknaedeLKRKSDAEKEAAKQKQRALDDlqkykmQAEEAERRMKQAEEEKIRQIRVVE 1494
Cdd:COG3206    292 DVIALRAQIAALRAQLQQEAQR-------ILASLEAELEALQAREASLQA------QLAQLEARLAELPELEAELRRLER 358

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1389908296 1495 EV-AQKSAATQLQTKAmsfseQTTKLEESLKKEQGNVL 1531
Cdd:COG3206    359 EVeVARELYESLLQRL-----EEARLAEALTVGNVRVI 391
Nup88 pfam10168
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...
 1308-1554 5.49e-04

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.


Pssm-ID: 462975 [Multi-domain]  Cd Length: 713  Bit Score: 46.19  E-value: 5.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1308 KSVAKAEQEALELKMK----MKEEASKRQDVAadaekqkqniQQELQ-HLKSLSDQeiksKNQQLEDalvsrrkieeeih 1382
Cdd:pfam10168  524 KLSSPSPQECLQLLSRatqvFREEYLKKHDLA----------REEIQkRVKLLKLQ----KEQQLQE------------- 576

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1383 iiriqlekttahkakseaeLQELRDraaEAEKLRKAAQDEAERLR----KQvaEETQRK-----KNAEDELKRKSDAEKE 1453
Cdd:pfam10168  577 -------------------LQSLEE---ERKSLSERAEKLAEKYEeikdKQ--EKLMRRckkvlQRLNSQLPVLSDAERE 632

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1454 AAKQkqralddLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQksaatQLQTKAMSFSEqttkleeslkkEQGNVLK- 1532
Cdd:pfam10168  633 MKKE-------LETINEQLKHLANAIKQAKKKMNYQRYQIAKSQS-----IRKKSSLSLSE-----------KQRKTIKe 689

                          250       260
                   ....*....|....*....|...
gi 1389908296 1533 -LQEEADKLKKQQKEANTAREEA 1554
Cdd:pfam10168  690 iLKQLGSEIDELIKQVKDINKHV 712
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 1403-1525 6.22e-04

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 45.36  E-value: 6.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1403 QELRDRAAEAEKLRKAAQDEAERLRKQVAEEtqRKKNAEDELKRKSDAEKEAAKQKQRALddlqkyKMQAEEAERRMKQA 1482
Cdd:pfam07767  198 QELLQKAVEAEKKRLKEEEKLERVLEKIAES--AATAEAREEKRKTKAQRNKEKRRKEEE------REAKEEKALKKKLA 269

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1389908296 1483 EEEKIRQIRvvEEVAQKSAATQLQTKAMSFSEQTTKLEESLKK 1525
Cdd:pfam07767  270 QLERLKEIA--KEIAEKEKEREEKAEARKREKRKKKKEEKKLR 310
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2393-2540 6.37e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2393 ANAQQEQIEQQKAELQQsfltEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALkdeQERQRKLmEEERKKLQAIMDEAV 2472
Cdd:COG1196    237 LEAELEELEAELEELEA----ELEELEAELAELEAELEELRLELEELELELEEA---QAEEYEL-LAELARLEQDIARLE 308

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2473 RKQKEAEEEMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKLVA 2540
Cdd:COG1196    309 ERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 2213-2407 6.40e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.22  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2213 QIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQIQQRLDKETEgfQKSLEAERKR 2292
Cdd:TIGR02794   36 EIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKA--AKQAEQAAKQ 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2293 QLEASAEAEKLKLrvKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIvvqKLETQRLQSTREADDLKSAIADLE 2372
Cdd:TIGR02794  114 AEEKQKQAEEAKA--KQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEA---KKKAEEAKKKAEAEAKAKAEAEAK 188

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1389908296 2373 EERKKLKKEAEELQRKSKEMANAQQEQIEQQKAEL 2407
Cdd:TIGR02794  189 AKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAA 223
PTZ00491 PTZ00491
major vault protein; Provisional
 1650-1786 7.05e-04

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 45.78  E-value: 7.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1650 EHAEQQ-RGLLdnELQRLKNEVnSTEKQRKQLedelnkvrsemdslLQMKinAEKASMVNTEKSKQ--LLESEALKMKQL 1726
Cdd:PTZ00491   673 ELLEQEaRGRL--ERQKMHDKA-KAEEQRTKL--------------LELQ--AESAAVESSGQSRAeaLAEAEARLIEAE 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1727 AD-EAARMRSVAE------EAKKQRQIAEEEAARQRSEAE-KILKEKLAAINEATRLK---------TEAEMA-----LK 1784
Cdd:PTZ00491   734 AEvEQAELRAKALrieaeaELEKLRKRQELELEYEQAQNElEIAKAKELADIEATKFErivealgreTLIAIAragpeLQ 813


                   ..
gi 1389908296 1785 AK 1786
Cdd:PTZ00491   814 AK 815
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1389-1624 7.06e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.79  E-value: 7.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1389 EKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKK---------NAEDELKRKSDAEKEAAKQKQ 1459
Cdd:pfam05667  255 QLRSAALAGTEATSGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTEklqftneapAATSSPPTKVETEEELQQQRE 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1460 RALDDLQKykmQAEEAERRMKQAEEE------KIRQirVVEEVAQKSAATQLQTKAMSFSEQTTKLeesLKKEQGNVLKL 1533
Cdd:pfam05667  335 EELEELQE---QLEDLESSIQELEKEikklesSIKQ--VEEELEELKEQNEELEKQYKVKKKTLDL---LPDAEENIAKL 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1534 QEEADKLKkqQKEANTAREeaeqeleiWrqkanEALRLRLQAEEEAQKKSHAQEEAE-KQKLEAERDAKKRGKAEEAALK 1612
Cdd:pfam05667  407 QALVDASA--QRLVELAGQ--------W-----EKHRVPLIEEYRALKEAKSNKEDEsQRKLEEIKELREKIKEVAEEAK 471

                          250
                   ....*....|..
gi 1389908296 1613 QKENAEKELDKQ 1624
Cdd:pfam05667  472 QKEELYKQLVAE 483
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 2207-2408 7.10e-04

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 44.81  E-value: 7.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2207 ETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQ-KQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKS 2285
Cdd:pfam17045   57 EIGLLRQQLEELEKGKQELVAKYEQQLQKLQEELSKLKRSYEKLQrKQLKEAREEAKSREEDRSELSRLNGKLEEFRQKS 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2286 LEAERKR----QLEASAEAEKlKLRVKELSLAQTKAEDEAKKFKKQADE-VKAQLQR----TEKHTTEIVVQKLETQRLQ 2356
Cdd:pfam17045  137 LEWEQQRlqyqQQVASLEAQR-KALAEQSSLIQSAAYQVQLEGRKQCLEaSQSEIQRlrskLERAQDSLCAQELELERLR 215

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2357 StreaddLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQ 2408
Cdd:pfam17045  216 M------RVSELGDSNRKLLEEQQRLLEELRMSQRQLQVLQNELMELKATLQ 261
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1988-2305 7.23e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 7.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1988 KEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARR 2067
Cdd:COG5185    261 QNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQELEESKRETETGIQN 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2068 AAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDETDKQKVLLDQELQRVKGEVNDAF--------K 2139
Cdd:COG5185    341 LTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLedtlkaadR 420

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2140 QKSQVEVELARVRIQMEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSlaeeagRLSVEAEETARQRQIAESNL 2219
Cdd:COG5185    421 QIEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINR------SVRSKKEDLNEELTQIESRV 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2220 AEqralaekiLKEKMQaiQEATKLKAEAEKLQKQKDQAQETAKRLqEDKQQIQQRLDKETE----GFQKSLEAERKRQLE 2295
Cdd:COG5185    495 ST--------LKATLE--KLRAKLERQLEGVRSKLDQVAESLKDF-MRARGYAHILALENLipasELIQASNAKTDGQAA 563

                          330
                   ....*....|
gi 1389908296 2296 ASAEAEKLKL 2305
Cdd:COG5185    564 NLRTAVIDEL 573
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1494-1677 7.37e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 7.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1494 EEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALR--- 1570
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARaly 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1571 -------------------------LRLQAEEEAQKK-----SHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKE 1620
Cdd:COG3883     97 rsggsvsyldvllgsesfsdfldrlSALSKIADADADlleelKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1621 LDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQR 1677
Cdd:COG3883    177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
mukB PRK04863
chromosome partition protein MukB;
1290-1688 7.60e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.10  E-value: 7.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1290 AEIQAELDKQKQMA---EAHAKSVAKAEQEALELKMKMKEEASKRQDVAAdAEKQKQNIQQELQHLKSLsdqeiksknqq 1366
Cdd:PRK04863   897 EEIREQLDEAEEAKrfvQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQ-AQQTQRDAKQQAFALTEV----------- 964

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1367 ledalVSRRkieeeihiiriqlekttAHKAKSEA--------ELQE-LRDRAAEAEKLRKAAQDEAERLRKQVAEETQRK 1437
Cdd:PRK04863   965 -----VQRR-----------------AHFSYEDAaemlaknsDLNEkLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVL 1022

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1438 KNAEDELKRKSDAEKEAAKqkqraldDLQKYKMQA-EEAERRMKQAEEEKIRQIRvveevAQKSAATQLQTkamsfseQT 1516
Cdd:PRK04863  1023 ASLKSSYDAKRQMLQELKQ-------ELQDLGVPAdSGAEERARARRDELHARLS-----ANRSRRNQLEK-------QL 1083

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1517 TKLEESLKKEQGnvlklqeeadKLKKQQKEANTAREEAEQeleiwrQKANEALRLRLQAEEEAQKKSHAQEEAEkQKLEA 1596
Cdd:PRK04863  1084 TFCEAEMDNLTK----------KLRKLERDYHEMREQVVN------AKAGWCAVLRLVKDNGVERRLHRRELAY-LSADE 1146

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1597 ERDAkkRGKAEEAALKQKENAEKELDKQR-----KFAEQIAQ------QKLS--AEQECIRLKADFEHAEQqrglLDNEL 1663
Cdd:PRK04863  1147 LRSM--SDKALGALRLAVADNEHLRDVLRlsedpKRPERKVQfyiavyQHLRerIRQDIIRTDDPVEAIEQ----MEIEL 1220

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1389908296 1664 QRLKNEVNSTEKQ------------RKQLEDELNKVR 1688
Cdd:PRK04863  1221 SRLTEELTSREQKlaissesvaniiRKTIQREQNRIR 1257
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1503-1825 7.89e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 7.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1503 TQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKK 1582
Cdd:COG4372     48 EQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1583 SHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNE 1662
Cdd:COG4372    128 EQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1663 LQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKK 1742
Cdd:COG4372    208 LIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEA 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1743 QRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKI 1822
Cdd:COG4372    288 LEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGV 367


                   ...
gi 1389908296 1823 TQL 1825
Cdd:COG4372    368 ADG 370
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1729-1946 7.99e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.27  E-value: 7.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1729 EAARMRSVAEEAKKQRQIAEEEAARQRSEAE---KILKEKLAAINEATRLKTEAEMALKAKEAEnerLKRQAEEEAYQRK 1805
Cdd:pfam07888   42 ERAELLQAQEAANRQREKEKERYKRDREQWErqrRELESRVAELKEELRQSREKHEELEEKYKE---LSASSEELSEEKD 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1806 LLEDQAAQHKQDIEE------KITQLQTSSDSELGRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLK 1879
Cdd:pfam07888  119 ALLAQRAAHEARIREleedikTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELR 198

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1880 GIADETQKSKLKAEEEAEKLKKLAAEEerrrkeaeekvKRITAAEEEAARQCKAAQEEVERLKKKAE 1946
Cdd:pfam07888  199 NSLAQRDTQVLQLQDTITTLTQKLTTA-----------HRKEAENEALLEELRSLQERLNASERKVE 254
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1652-1934 8.08e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 8.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1652 AEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKvrsemdslLQMKINAEKASMVNTEKSKQLLESEalkMKQLADEAA 1731
Cdd:COG4942     25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAA--------LERRIAALARRIRALEQELAALEAE---LAELEKEIA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1732 RMRsvAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEAtrlktEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQA 1811
Cdd:COG4942     94 ELR--AELEAQKEELAELLRALYRLGRQPPLALLLSPEDFL-----DAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1812 AQHKQDIEEKITQLQtssdselgrqkniveetlkqkkvveeeihiikinfhKASKEKADLESELKKLKGIADETQKSKLK 1891
Cdd:COG4942    167 AELEAERAELEALLA------------------------------------ELEEERAALEALKAERQKLLARLEKELAE 210

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1389908296 1892 AEEEAEKLKKlaaeeerRRKEAEEKVKRITAAEEEAARQCKAA 1934
Cdd:COG4942    211 LAAELAELQQ-------EAEELEALIARLEAEAAAAAERTPAA 246
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 2179-2477 8.64e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.71  E-value: 8.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2179 STQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAE-QRAL--AEKI-------------LKEKMQAIQEATK 2242
Cdd:COG3096    296 GARRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLvQTALrqQEKIeryqedleelterLEEQEEVVEEAAE 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2243 LKAEAEKlqkQKDQAQETAKRLQEDKQQIQQRLD-KETEGFQKsleaerkRQ-LEASAEAEKLkLRVKELSLAQtkAEDE 2320
Cdd:COG3096    376 QLAEAEA---RLEAAEEEVDSLKSQLADYQQALDvQQTRAIQY-------QQaVQALEKARAL-CGLPDLTPEN--AEDY 442

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2321 AKKFKKQADEVKAQLQRTEkhtteivvQKL---ETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQ 2397
Cdd:COG3096    443 LAAFRAKEQQATEEVLELE--------QKLsvaDAARRQFEKAYELVCKIAGEVERSQAWQTARELLRRYRSQQALAQRL 514

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2398 EQIEQQKAELQQsfltekglLLKREKEVEGEKKRFEKQ----------LEDEMKKAKALKDEQERQRKLMEEERKKLQAI 2467
Cdd:COG3096    515 QQLRAQLAELEQ--------RLRQQQNAERLLEEFCQRigqqldaaeeLEELLAELEAQLEELEEQAAEAVEQRSELRQQ 586

                          330
                   ....*....|
gi 1389908296 2468 MDEAVRKQKE 2477
Cdd:COG3096    587 LEQLRARIKE 596
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2174-2533 9.06e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.89  E-value: 9.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2174 QKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQ 2253
Cdd:COG4372      9 GKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQ 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2254 KDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKA 2333
Cdd:COG4372     89 LQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAA 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2334 QLQRTEKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAELQQSFLT 2413
Cdd:COG4372    169 LEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDK 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2414 EKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKEAEEEMKNKQREMDVLD 2493
Cdd:COG4372    249 EELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKL 328

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1389908296 2494 KKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTV 2533
Cdd:COG4372    329 ELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVA 368
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 2403-2518 9.25e-04

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 44.59  E-value: 9.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2403 QKAELQQSFLTEKglllkreKEVEGEKKRFEKQL---EDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEAVRKQKE-- 2477
Cdd:pfam02841  173 KAEEVLQEFLQSK-------EAVEEAILQTDQALtakEKAIEAERAKAEAAEAEQELLREKQKEEEQMMEAQERSYQEhv 245

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2478 ------AEEEMKNKQREMD-VLDKKRLEQEKQLAE----ENKKLREQLQTFE 2518
Cdd:pfam02841  246 kqliekMEAEREQLLAEQErMLEHKLQEQEELLKEgfktEAESLQKEIQDLK 297
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 1429-1596 9.45e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 43.93  E-value: 9.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1429 QVAEETQRKKNAEDELKRKSDAEKE---AAKQKQRalddlqKYKMQAEEAERRMKQAEEEKiRQirvveEVAQKSAATQL 1505
Cdd:pfam13904   34 QSSSLTYARKLEGLKLERQPLEAYEnwlAAKQRQR------QKELQAQKEEREKEEQEAEL-RK-----RLAKEKYQEWL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1506 QTKAmsfsEQTTKLEESLKKEQGNvLKLQEEADKLKKQQKEantarEEAEQELEIWRQKANEALRLRLQAEEEAQKKSHA 1585
Cdd:pfam13904  102 QRKA----RQQTKKREESHKQKAA-ESASKSLAKPERKVSQ-----EEAKEVLQEWERKKLEQQQRKREEEQREQLKKEE 171

                          170
                   ....*....|.
gi 1389908296 1586 QEEAEKQKLEA 1596
Cdd:pfam13904  172 EEQERKQLAEK 182
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 1395-1467 1.01e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 42.04  E-value: 1.01e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1395 KAKSEAELQELRdraAEAEKLRKAAQDEAERLRKQVAEETQRKKNaedelKRKSDAEKEAAKQKQRALDDLQK 1467
Cdd:cd06503     53 LAEYEEKLAEAR---AEAQEIIEEARKEAEKIKEEILAEAKEEAE-----RILEQAKAEIEQEKEKALAELRK 117
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
2386-2506 1.03e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 44.86  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2386 QRKSKEMANAQQEQiEQQKAELQQSflTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKAlkdeqERQRKLMEEERKKLQ 2465
Cdd:COG2268    208 AERETEIAIAQANR-EAEEAELEQE--REIETARIAEAEAELAKKKAEERREAETARAEA-----EAAYEIAEANAEREV 279

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1389908296 2466 AIMDEAVRKQKEAEEEMKNKQREMDVLD---KKRLEQEKQLAEE 2506
Cdd:COG2268    280 QRQLEIAEREREIELQEKEAEREEAELEadvRKPAEAEKQAAEA 323
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
2167-2426 1.05e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2167 EENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAgrlsvEAEETARQRQIAESNLAEQRALAEKILKEkmqaiqeatklkae 2246
Cdd:COG3206    163 EQNLELRREEARKALEFLEEQLPELRKELEEA-----EAALEEFRQKNGLVDLSEEAKLLLQQLSE-------------- 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2247 aekLQKQKDQAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEAsaEAEKLKLRVKELSLAQTKAEDEAKKFKK 2326
Cdd:COG3206    224 ---LESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRA--QLAELEAELAELSARYTPNHPDVIALRA 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2327 QADEVKAQLQRTekhtTEIVVQKLETQRLQSTREADDLKSAIADleeerkklkkeaeeLQRKSKEMANAQQEQIE-QQKA 2405
Cdd:COG3206    299 QIAALRAQLQQE----AQRILASLEAELEALQAREASLQAQLAQ--------------LEARLAELPELEAELRRlEREV 360

                          250       260
                   ....*....|....*....|.
gi 1389908296 2406 ELQQSFLTEkglLLKREKEVE 2426
Cdd:COG3206    361 EVARELYES---LLQRLEEAR 378
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1670-2004 1.08e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.11  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1670 VNSTEKQRKQLEDELNKVRSEMDSLLQmkinaekasmvNTEKSKQLLESEALKMKQLADEAA----RMRSVAEEAKKQRQ 1745
Cdd:pfam17380  284 VSERQQQEKFEKMEQERLRQEKEEKAR-----------EVERRRKLEEAEKARQAEMDRQAAiyaeQERMAMERERELER 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1746 IAEEEAARqrsEAEKILKEKLAAinEATRLKtEAEMALKAKEAENERLkRQAEEEAYQRKLLEDQaaQHKQDIEEKITQL 1825
Cdd:pfam17380  353 IRQEERKR---ELERIRQEEIAM--EISRMR-ELERLQMERQQKNERV-RQELEAARKVKILEEE--RQRKIQQQKVEME 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1826 QTSSDSELGRQKNIveETLKQKKVVEEEihiikinfhKASKEKADLESELKKLKgiADETQKSKLKAEEEAEKLKKLAAE 1905
Cdd:pfam17380  424 QIRAEQEEARQREV--RRLEEERAREME---------RVRLEEQERQQQVERLR--QQEEERKRKKLELEKEKRDRKRAE 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1906 EERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAA--EQKAQDV 1983
Cdd:pfam17380  491 EQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKAteERSRLEA 570

                          330       340
                   ....*....|....*....|....
gi 1389908296 1984 LSKNKE---DVLAQEKLRDEFENA 2004
Cdd:pfam17380  571 MEREREmmrQIVESEKARAEYEAT 594
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2179-2370 1.09e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2179 STQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQiaesNLAEQRALAEKILKEKMQAIqEATKLKAEAEKLQKQKDQAQ 2258
Cdd:COG4913    607 DNRAKLAALEAELAELEEELAEAEERLEALEAELD----ALQERREALQRLAEYSWDEI-DVASAEREIAELEAELERLD 681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2259 ETAKRLQEDKQQIQQrLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQ-ADEVKAQLQR 2337
Cdd:COG4913    682 ASSDDLAALEEQLEE-LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAlLEERFAAALG 760

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1389908296 2338 TEKHTTeiVVQKLETQRLQSTREADDLKSAIAD 2370
Cdd:COG4913    761 DAVERE--LRENLEERIDALRARLNRAEEELER 791
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 2167-2275 1.13e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 41.83  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2167 EENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAE 2246
Cdd:pfam20492   12 EERLKQYEEETKKAQEELEESEETAEELEEERRQAEEEAERLEQKRQEAEEEKERLEESAEMEAEEKEQLEAELAEAQEE 91

                           90       100
                   ....*....|....*....|....*....
gi 1389908296 2247 AEKLQKQKDQAQETAKRLQEDKQQIQQRL 2275
Cdd:pfam20492   92 IARLEEEVERKEEEARRLQEELEEAREEE 120
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 2026-2370 1.14e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 45.13  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2026 RQKAEEAEKQKKAAENEAAK----QAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHK-----------K 2090
Cdd:pfam09731  100 EVAEEEKEATKDAAEAKAQLpkseQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKeasdtaeisreK 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2091 EAEQALQQKSQVEKEL--TVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVElarvriQMEELVKLKLKI-EE 2167
Cdd:pfam09731  180 ATDSALQKAEALAEKLkeVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKA------QSLAKLVDQYKElVA 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2168 ENRRLMQKDKDST-QKLLAEEAEKMKSLAEEAGRL--SVEAEETARQRQIAESNLAEQRALAEKILKekmqaiQEATKLK 2244
Cdd:pfam09731  254 SERIVFQQELVSIfPDIIPVLKEDNLLSNDDLNSLiaHAHREIDQLSKKLAELKKREEKHIERALEK------QKEELDK 327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2245 AEAEKLQKQKDQaqetakrLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQ---------- 2314
Cdd:pfam09731  328 LAEELSARLEEV-------RAADEAQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIelqreflqdi 400

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2315 -TKAEDEAKKFKKQADEVKAQLQRTEKHTTEIVV---QKLETQRLQSTREA--DDLKSAIAD 2370
Cdd:pfam09731  401 kEKVEEERAGRLLKLNELLANLKGLEKATSSHSEvedENRKAQQLWLAVEAlrSTLEDGSAD 462
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1784-2044 1.15e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1784 KAKEAENERLKRQAEEEAyqrklleDQAAQHKQDIEEKITQLQTSSDSELGRQKNiveetLKQKKVVEEEihiikinfhK 1863
Cdd:TIGR02794   46 GAVAQQANRIQQQKKPAA-------KKEQERQKKLEQQAEEAEKQRAAEQARQKE-----LEQRAAAEKA---------A 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1864 ASKEKADLESELKKlkgiadeTQKSKLKAEEEAEKLKKLAaeeerrrkeaeekvkritAAEEEAARQCKAAQEEVERLKK 1943
Cdd:TIGR02794  105 KQAEQAAKQAEEKQ-------KQAEEAKAKQAAEAKAKAE------------------AEAERKAKEEAAKQAEEEAKAK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1944 KAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAA 2023
Cdd:TIGR02794  160 AAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFG 239

                          250       260
                   ....*....|....*....|.
gi 1389908296 2024 LlrQKAEEAEKQKKAAENEAA 2044
Cdd:TIGR02794  240 L--ASGSNAEKQGGARGAAAG 258
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1387-1813 1.16e-03

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 44.90  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1387 QLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRkknaedelKRKSDAEKEAAKQKQRALDDLQ 1466
Cdd:COG5278    111 ELEALIDQWLAELEQVIALRRAGGLEAALALVRSGEGKALMDEIRARLLL--------LALALAALLLAAAALLLLLLAL 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKE 1546
Cdd:COG5278    183 AALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALALLLAALLLALLAALALAAL 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1547 ANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRK 1626
Cdd:COG5278    263 LAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAAALAALLALALATALAAAAA 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1627 FAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASM 1706
Cdd:COG5278    343 ALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAAAAAEAAAAAAAAAAASAAEAL 422

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1707 VNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAK 1786
Cdd:COG5278    423 ELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAALAAAAAALAEAEAAAALAAAAALSLA 502

                          410       420
                   ....*....|....*....|....*..
gi 1389908296 1787 EAENERLKRQAEEEAYQRKLLEDQAAQ 1813
Cdd:COG5278    503 LALAALLLAAAEAALAAALAAALASAE 529
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 1402-1634 1.16e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 44.20  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1402 LQELRDRAAEAEK------LRKAAQDEAERLRKQVAEETQRKKnaeDELKRKSdaEKEAAKQKQRALDDLqkykmqAEEA 1475
Cdd:pfam02841   67 LQELLDLHRDCEKeaiavfMKRSFKDENQEFQKELVELLEAKK---DDFLKQN--EEASSKYCSALLQDL------SEPL 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1476 ERRMKQAEEEK-------IRQIRVVEEVAQKSAATQLQTKAM--SFSEQTTKLEESLkkeqgnvLKLQEEADKLKKQQKE 1546
Cdd:pfam02841  136 EEKISQGTFSKpggyklfLEERDKLEAKYNQVPRKGVKAEEVlqEFLQSKEAVEEAI-------LQTDQALTAKEKAIEA 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1547 ANTAREEAEQELEIWRQKANEalrlrLQAEEEAQKKSHAQEEAE-KQKLEAERDAKKRGKAEEAALKQKENAEKELDKQR 1625
Cdd:pfam02841  209 ERAKAEAAEAEQELLREKQKE-----EEQMMEAQERSYQEHVKQlIEKMEAEREQLLAEQERMLEHKLQEQEELLKEGFK 283


                   ....*....
gi 1389908296 1626 KFAEQIAQQ 1634
Cdd:pfam02841  284 TEAESLQKE 292
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 2025-2540 1.23e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2025 LRQKAEEAEKQKKAAEN-----EAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQK 2099
Cdd:pfam05557   23 LEHKRARIELEKKASALkrqldRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKLNEKESQLADA 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2100 SQV----EKELTVVKLQLDETDKQKVLLDQELQRVKgEVNDAFKQK-SQVEVELARVRIQMEELVKLKLKIEEENRRLMQ 2174
Cdd:pfam05557  103 REVisclKNELSELRRQIQRAELELQSTNSELEELQ-ERLDLLKAKaSEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQS 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2175 KDKDSTQ-KLLAEEAEKMKSLAEEAGRLSVEAE---ETARQRQIAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKL 2250
Cdd:pfam05557  182 QEQDSEIvKNSKSELARIPELEKELERLREHNKhlnENIENKLLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQEL 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2251 QKQKDQAQETA------KRLQEDKQQIQQRldKETEGFQKSLEAERKRQLEASaeaekLKLRVKELSLAQTKAEDEAKKF 2324
Cdd:pfam05557  262 QSWVKLAQDTGlnlrspEDLSRRIEQLQQR--EIVLKEENSSLTSSARQLEKA-----RRELEQELAQYLKKIEDLNKKL 334

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2325 KKQaDEVKAQLQRT---------------EKHTTEIVVQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKS 2389
Cdd:pfam05557  335 KRH-KALVRRLQRRvllltkerdgyrailESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGY 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2390 KEMANAQQEQIE---QQKAELQQSFLTEKGLLLKRE-KEVEGEKKRFEKQledemkkakalKDEQErqrklMEEERKKLQ 2465
Cdd:pfam05557  414 KQQAQTLERELQalrQQESLADPSYSKEEVDSLRRKlETLELERQRLREQ-----------KNELE-----MELERRCLQ 477

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2466 AIMDEAVRKQKEAEEEMKNKQREmdvldkKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKLVA 2540
Cdd:pfam05557  478 GDYDPKKTKVLHLSMNPAAEAYQ------QRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVL 546
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 2386-2509 1.26e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.41  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2386 QRKSKEMANAQQE---QIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERK 2462
Cdd:PRK09510    68 QQQQKSAKRAEEQrkkKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKA 147

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 2463 KLQAIMDEAVRKQKEAEEEMKnKQREMDVLDKKRLEQEKQLAEENKK 2509
Cdd:PRK09510   148 KAEAEAKRAAAAAKKAAAEAK-KKAEAEAAKKAAAEAKKKAEAEAAA 193
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 1393-1467 1.30e-03

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 42.47  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1393 AHKAKSEAELQElrdraAEAEKLRKAAQDEAERLRKQVAEETQR-----KKNAEDELKR-KSDAEKEAAKQKQRALDDLQ 1466
Cdd:COG0711     43 AERAKEEAEAAL-----AEYEEKLAEARAEAAEIIAEARKEAEAiaeeaKAEAEAEAERiIAQAEAEIEQERAKALAELR 117


                   .
gi 1389908296 1467 K 1467
Cdd:COG0711    118 A 118
PRK12705 PRK12705
hypothetical protein; Provisional
 2173-2328 1.46e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 44.70  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2173 MQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNL--AEQRALAEKILKEKMQAIQEATKLKAEAEKL 2250
Cdd:PRK12705    28 RQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARRerEELQREEERLVQKEEQLDARAEKLDNLENQL 107

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 2251 QKQKDQAQETAKRLQEDKQQIQQRLdKETEGF-QKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQA 2328
Cdd:PRK12705   108 EEREKALSARELELEELEKQLDNEL-YRVAGLtPEQARKLLLKLLDAELEEEKAQRVKKIEEEADLEAERKAQNILAQA 185
PTZ00491 PTZ00491
major vault protein; Provisional
 1267-1370 1.56e-03

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 44.62  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1267 AQRRLEDDEKAseklkEEERRKMAEIQAELDKQKQ--MAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADAE--KQK 1342
Cdd:PTZ00491   684 ERQKMHDKAKA-----EEQRTKLLELQAESAAVESsgQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAEleKLR 758

                           90       100
                   ....*....|....*....|....*...
gi 1389908296 1343 QNIQQELQHLKSLSDQEIKsKNQQLEDA 1370
Cdd:PTZ00491   759 KRQELELEYEQAQNELEIA-KAKELADI 785
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1514-1941 1.56e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.81  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1514 EQTTKLEESLKKeQGNVLKLQEEADKLKKQQKEANTAREEAEQELEiwrQKANEALRLRlqaeEEAQKKSHAQEEAEK-- 1591
Cdd:pfam10174  158 ESIKKLLEMLQS-KGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLD---QKEKENIHLR----EELHRRNQLQPDPAKtk 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1592 --QKLEAERDAK----KRG--KAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAE---QECIRLKADFEHAEQQRGLLD 1660
Cdd:pfam10174  230 alQTVIEMKDTKisslERNirDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKfmkNKIDQLKQELSKKESELLALQ 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1661 NELQRLKNEvNSTEKQRKQLEDELNKVRSEMDSLLQMKINA------EKASMVNtEKSKQLLE---------SEALKMKQ 1725
Cdd:pfam10174  310 TKLETLTNQ-NSDCKQHIEVLKESLTAKEQRAAILQTEVDAlrlrleEKESFLN-KKTKQLQDlteekstlaGEIRDLKD 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1726 LADEAARMRSVAEeaKKQRQIAEEEAARQRSEAEkiLKEKLAAI-----NEATRLKTeAEMALKAKEAENERLKRQAEEE 1800
Cdd:pfam10174  388 MLDVKERKINVLQ--KKIENLQEQLRDKDKQLAG--LKERVKSLqtdssNTDTALTT-LEEALSEKERIIERLKEQRERE 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1801 AYQRKLLEDQAAQHKQDIEEKITQLQT------SSDSELGRQKNIVEETLKQKkvvEEEIHIIKINFHKASKEKADLESE 1874
Cdd:pfam10174  463 DRERLEELESLKKENKDLKEKVSALQPeltekeSSLIDLKEHASSLASSGLKK---DSKLKSLEIAVEQKKEECSKLENQ 539

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1389908296 1875 LKKLKGIADETQKSklkaEEEAEKLKKLAaeeerrrkeaeekvKRITAAEEEAARqckaAQEEVERL 1941
Cdd:pfam10174  540 LKKAHNAEEAVRTN----PEINDRIRLLE--------------QEVARYKEESGK----AQAEVERL 584
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1594-2040 1.56e-03

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 44.51  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1594 LEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNST 1673
Cdd:COG5278     78 LEPYEEARAEIDELLAELRSLTADNPEQQARLDELEALIDQWLAELEQVIALRRAGGLEAALALVRSGEGKALMDEIRAR 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1674 EKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAAR 1753
Cdd:COG5278    158 LLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAA 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1754 QRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKITQLQTSSDSEL 1833
Cdd:COG5278    238 LALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAA 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1834 GRQKNIVEETLKQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEA 1913
Cdd:COG5278    318 AAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAA 397

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1914 EEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLA 1993
Cdd:COG5278    398 AAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAAL 477

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1389908296 1994 QEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAE 2040
Cdd:COG5278    478 AAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALAAA 524
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1444-1667 1.73e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1444 LKRKSDAEKEAAKQKQRALDDlqkykmQAEEAERRMKQAEEEkirqirvVEEVAQKSAATQLQTKAMSFSEQTTKLEESL 1523
Cdd:COG3206    162 LEQNLELRREEARKALEFLEE------QLPELRKELEEAEAA-------LEEFRQKNGLVDLSEEAKLLLQQLSELESQL 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1524 KKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEA-LRLRLQAEEEAQKKSH-------AQEEAEKQKLE 1595
Cdd:COG3206    229 AEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAeLEAELAELSARYTPNHpdvialrAQIAALRAQLQ 308

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 1596 AERDAKKRG-KAEEAALKQKENA-EKELDKQRKFAEQIAQQklsaEQECIRLKADFEHAEQqrgLLDNELQRLK 1667
Cdd:COG3206    309 QEAQRILASlEAELEALQAREASlQAQLAQLEARLAELPEL----EAELRRLEREVEVARE---LYESLLQRLE 375
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1966-2138 1.76e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.03  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1966 AKEAAQKCTAAEQKAQDVlskNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAAENEAAK 2045
Cdd:PRK09510    89 AEELQQKQAAEQERLKQL---EKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKAAA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2046 QAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQ-----KSQVEKELTVVKLQLDETDKQK 2120
Cdd:PRK09510   166 EAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKaaaeaKAAAAKAAAEAKAAAEKAAAAK 245

                          170
                   ....*....|....*...
gi 1389908296 2121 VLLDQELQRVKGEVNDAF 2138
Cdd:PRK09510   246 AAEKAAAAKAAAEVDDLF 263
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1306-1626 1.76e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1306 HAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKslsdQEIKSKNQQLEDALVSRRKIEEEIHIIR 1385
Cdd:COG4372      4 LGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLR----EELEQAREELEQLEEELEQARSELEQLE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1386 IQLEKTtahkaksEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDL 1465
Cdd:COG4372     80 EELEEL-------NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEEL 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1466 QKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQK 1545
Cdd:COG4372    153 KELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLG 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1546 EANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQR 1625
Cdd:COG4372    233 LALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGA 312


                   .
gi 1389908296 1626 K 1626
Cdd:COG4372    313 L 313
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1458-1823 1.82e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 44.26  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1458 KQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEA 1537
Cdd:COG3064      6 EEKAAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEEAREAKAEAEQRAAELAAEAAKKLAEAEKA 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1538 DKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENA 1617
Cdd:COG3064     86 AAEAEKKAAAEKAKAAKEAEAAAAAEKAAAAAEKEKAEEAKRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAA 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1618 EKELDKQRKFAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQM 1697
Cdd:COG3064    166 AAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEAAL 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1698 KINAEKASMVNTEKSKQLLESEALKMKQLADEAARMRSVAEEAKKQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKT 1777
Cdd:COG3064    246 GGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLAAAAAAG 325

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1389908296 1778 EAEMALKAKEAENERLKRQAEEEAYQRKLLEDQAAQHKQDIEEKIT 1823
Cdd:COG3064    326 ALVVRGGGAASLEAALSLLAAGAAAAAAGAGALATGALGDALAAEA 371
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 2244-2495 1.92e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 44.55  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2244 KAEAeKLQKQKDQAQETAKRLQEDKqqiQQRLDKEtegfqkslEAERKRQLEASAEAeklklRVKELSLAQTKAEDEAKK 2323
Cdd:PRK05035   435 KAEI-RAIEQEKKKAEEAKARFEAR---QARLERE--------KAAREARHKKAAEA-----RAAKDKDAVAAALARVKA 497

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2324 FKKQADEVKAQLQRTEKHTTEIVVQ--------KLETQRLQSTREADDLKSAIA---------DLEEERKKLKKEAEELQ 2386
Cdd:PRK05035   498 KKAAATQPIVIKAGARPDNSAVIAArearkaqaRARQAEKQAAAAADPKKAAVAaaiarakakKAAQQAANAEAEEEVDP 577

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2387 RKSK---EMANAQQEQIEQQKAELQQSfltekglllkrekEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKK 2463
Cdd:PRK05035   578 KKAAvaaAIARAKAKKAAQQAASAEPE-------------EQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPR 644

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1389908296 2464 LQAIMDEAVR-KQKEAEEEMKNKQREMDVLDKK 2495
Cdd:PRK05035   645 KAAVAAAIARaKARKAAQQQANAEPEEAEDPKK 677
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 2266-2506 1.93e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 44.17  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2266 EDKQQIQQRLdKETEGFQKSLEAERKRQleasAEAEKLKLRVKELslaqtkaedeakkfkKQADEVKAQLQRTEKHTTEI 2345
Cdd:pfam15709  329 EQEKASRDRL-RAERAEMRRLEVERKRR----EQEEQRRLQQEQL---------------ERAEKMREELELEQQRRFEE 388

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2346 VvqKLETQRLQSTREaddlksaiadleeerkklkkeaeelQRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEV 2425
Cdd:pfam15709  389 I--RLRKQRLEEERQ-------------------------RQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQ 441

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2426 EgEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQaimdeavRKQKEAEE----EMKNKQREMDVLDKKRLEQEK 2501
Cdd:pfam15709  442 E-EAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEYQ-------RQKQEAEEkarlEAEERRQKEEEAARLALEEAM 513


                   ....*
gi 1389908296 2502 QLAEE 2506
Cdd:pfam15709  514 KQAQE 518
Spectrin pfam00435
Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in ...
 551-631 1.98e-03

Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteriztic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in multiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.


Pssm-ID: 395348 [Multi-domain]  Cd Length: 105  Bit Score: 40.76  E-value: 1.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  551 WLNEKEEEEVNYDWSDKNTNMTAKKDNYSGLMRELELREKKVNAVQTTGDKLLRDGHPARKTIEAFTAALQTQWSWLLQL 630
Cdd:pfam00435   16 WIEEKEALLSSEDYGKDLESVQALLKKHKALEAELAAHQDRVEALNELAEKLIDEGHYASEEIQERLEELNERWEQLLEL 95


                   .
gi 1389908296  631 C 631
Cdd:pfam00435   96 A 96
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1315-1578 2.15e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 2.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1315 QEALElKMKMKEEASKRQDVAADAEKQKQNIQQELQHLKSLSDQ--EIKSKNQQLEDALVSRRKIEEEihiiriqLEKTt 1392
Cdd:COG2433    379 EEALE-ELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQveRLEAEVEELEAELEEKDERIER-------LERE- 449

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1393 AHKAKSEAELQELRDRaaEAEKLRKaaqdEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQA 1472
Cdd:COG2433    450 LSEARSEERREIRKDR--EISRLDR----EIERLERELEEERERIEELKRKLERLKELWKLEHSGELVPVKVVEKFTKEA 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1473 -EEAERRMKQAEeekiRQIRVVEEV--AQKSAATQL---QTKAMSFSEQT-TKLEESLKKEQGNVLKLQE----EADKLk 1541
Cdd:COG2433    524 iRRLEEEYGLKE----GDVVYLRDAsgAGRSTAELLaeaGPRAVIVPGELsEAADEVLFEEGIPVLPAEDvtiqEVDDL- 598

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1389908296 1542 kqqkeANTAREEAEQELEIWRQKANEalRLRLQAEEE 1578
Cdd:COG2433    599 -----AVVDEEELEAAIEDWEERAEE--RRREKKAEM 628
PRK05759 PRK05759
F0F1 ATP synthase subunit B; Validated
 1532-1614 2.18e-03

F0F1 ATP synthase subunit B; Validated


Pssm-ID: 180240 [Multi-domain]  Cd Length: 156  Bit Score: 41.69  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1532 KLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEalrLRLQAEEEAQK-----KSHAQEEAEKQKLEAERDAKKRGKA 1606
Cdd:PRK05759    39 KIADGLAAAERAKKELELAQAKYEAQLAEARAEAAE---IIEQAKKRAAQiieeaKAEAEAEAARIKAQAQAEIEQERKR 115


                   ....*...
gi 1389908296 1607 EEAALKQK 1614
Cdd:PRK05759   116 AREELRKQ 123
CH_SMTNL1 cd21260
calponin homology (CH) domain found in smoothelin-like protein 1; Smoothelin-like protein 1 ...
 111-168 2.24e-03

calponin homology (CH) domain found in smoothelin-like protein 1; Smoothelin-like protein 1 (SMTNL1), also called calponin homology-associated smooth muscle protein (CHASM), plays a role in the regulation of contractile properties of both striated and smooth muscles. It can bind to calmodulin and tropomyosin. When it is unphosphorylated, SMTNL1 may inhibit myosin dephosphorylation. SMTNL1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409109  Cd Length: 116  Bit Score: 40.84  E-value: 2.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAERELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21260     44 PDAFDYAELDPANRRHNFTLAFSTAEKHADCAPLLEVEDmVRMSVPDSKCVYTYIQELY 102
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 1467-1791 2.26e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 44.17  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERrmKQAEEEKIR----QIRVVEEVAQKSAAtqLQTKAmsfseqttkleESLKKEQGNVLKLQEEADKLKK 1542
Cdd:PRK05035   435 KAEIRAIEQEK--KKAEEAKARfearQARLEREKAAREAR--HKKAA-----------EARAAKDKDAVAAALARVKAKK 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1543 QQKEANTArEEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAerdAKKRGKAEEAALKQK--ENAEKE 1620
Cdd:PRK05035   500 AAATQPIV-IKAGARPDNSAVIAAREARKAQARARQAEKQAAAAADPKKAAVAA---AIARAKAKKAAQQAAnaEAEEEV 575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1621 LDKQRKFAEQIAqqklsaeqeciRLKAdfEHAEQQrglldnelqrlkNEVNSTEKQRKQLEDELNKVRSEmdsllqmkIN 1700
Cdd:PRK05035   576 DPKKAAVAAAIA-----------RAKA--KKAAQQ------------AASAEPEEQVAEVDPKKAAVAAA--------IA 622

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1701 AEKASMVNTEKSKQLLESEALKMKQLADEAARMRsvaeeAKKQRQIAEEEAArqrSEAEKILKEKLAAineatrlkteAE 1780
Cdd:PRK05035   623 RAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAK-----ARKAAQQQANAEP---EEAEDPKKAAVAA----------AI 684

                          330
                   ....*....|.
gi 1389908296 1781 MALKAKEAENE 1791
Cdd:PRK05035   685 ARAKAKKAAQQ 695
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1400-1603 2.28e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 43.36  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1400 AELQELRDRAAEAEKLRKAAQDEAERL---RKQVAEETQRKKNAEDELKRKSD---AEKEAAKQKQRALDDLQkYKMQAE 1473
Cdd:COG1340     50 AQVKELREEAQELREKRDELNEKVKELkeeRDELNEKLNELREELDELRKELAelnKAGGSIDKLRKEIERLE-WRQQTE 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 ----EAERR-MKQAE--EEKIRQIRVVEEVAQK-----SAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLK 1541
Cdd:COG1340    129 vlspEEEKElVEKIKelEKELEKAKKALEKNEKlkelrAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELR 208

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 1542 KQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKKR 1603
Cdd:COG1340    209 KEADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEKAE 270
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1866-2327 2.29e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.99  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1866 KEKADLESELKKLKGIADETQKSKLKAEEEAEKLKKLAAEEERRRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKA 1945
Cdd:COG4717     53 KEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1946 EDANKQKEKAEKEAEKQVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKAEKEAAlL 2025
Cdd:COG4717    133 ELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAE-L 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2026 RQKAEEAEKQKKAAENEAAKQAKAQNDTEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKE 2105
Cdd:COG4717    212 EEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFL 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2106 LTVVKLQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRI-----QMEELVKLKLKIEEENRRLMQKD-KDS 2179
Cdd:COG4717    292 LLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELlelldRIEELQELLREAEELEEELQLEElEQE 371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2180 TQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEKILkekmqAIQEATKLKAEAEKLQKQKDQAQE 2259
Cdd:COG4717    372 IAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELL-----EALDEEELEEELEELEEELEELEE 446

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2260 TAKRLQEDKQQIQQRLdKETEGFQKSLEAERKRQlEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQ 2327
Cdd:COG4717    447 ELEELREELAELEAEL-EQLEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREE 512
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1275-1509 2.31e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 44.17  E-value: 2.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1275 EKASEKLKEEERRKMAEIQAELDKQKQMAEahaksvAKAEQEALELKMKMKEEASKRQDVAADAEK-QKQNIQQELQHlk 1353
Cdd:pfam15709  331 EKASRDRLRAERAEMRRLEVERKRREQEEQ------RRLQQEQLERAEKMREELELEQQRRFEEIRlRKQRLEEERQR-- 402

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1354 slsdQEIKSKNQQLEdalvsrrkieeeihiirIQLEKTTAHKAKSE--AELQELRdraaeaeklRKAAQDEAERlrkqVA 1431
Cdd:pfam15709  403 ----QEEEERKQRLQ-----------------LQAAQERARQQQEEfrRKLQELQ---------RKKQQEEAER----AE 448

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1432 EETQRKKNAEDELKRKSDAEKEAAKQKQralddlQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKA 1509
Cdd:pfam15709  449 AEKQRQKELEMQLAEEQKRLMEMAEEER------LEYQRQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQA 520
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 2256-2406 2.35e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.84  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2256 QAQETAKRLQEDKQQIQQRldketegfQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQL 2335
Cdd:pfam05262  207 ESQEDAKRAQQLKEELDKK--------QIDADKAQQKADFAQDNADKQRDEVRQKQQEAKNLPKPADTSSPKEDKQVAEN 278

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2336 QRTEKHTTEIVVQKLETQRLQST-READDLKSaiaDLEEERKKLKKEAEELQRKSKEMANAQQEQIEQQKAE 2406
Cdd:pfam05262  279 QKREIEKAQIEIKKNDEEALKAKdHKAFDLKQ---ESKASEKEAEDKELEAQKKREPVAEDLQKTKPQVEAQ 347
PLEC smart00250
Plectin repeat;
4305-4342 2.46e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.23  E-value: 2.46e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4305 QRFLEVQYLTGGLIEPDATNRVAIDEAVKKGTLDARTA 4342
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1356-1557 2.56e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1356 SDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAERLRKQVAE--- 1432
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErar 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1433 ETQRKKNAEDEL-------------------KRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVV 1493
Cdd:COG3883     94 ALYRSGGSVSYLdvllgsesfsdfldrlsalSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1494 EEV--AQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQE 1557
Cdd:COG3883    174 EAQqaEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 1268-1585 2.58e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 43.49  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1268 QRRLEDDEKASEKLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKmKMKEEASKRQdvaadaekQKQNIQQ 1347
Cdd:pfam15558   61 EQWQAEKEQRKARLGREERRRADRREKQVIEKESRWREQAEDQENQRQEKLERA-RQEAEQRKQC--------QEQRLKE 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1348 ELQHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTahKAKSEAELQELRDRAAEAEKLRKA--------A 1419
Cdd:pfam15558  132 KEEELQALREQNSLQLQERLEEACHKRQLKEREEQKKVQENNLSE--LLNHQARKVLVDCQAKAEELLRRLsleqslqrS 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1420 QDEAERLRKQVAEETQRKKNAEDELKRKSdaeKEAAKQKQRALDdlQKYKMQAEEAERRMKQAEEekirqirVVEEVAQK 1499
Cdd:pfam15558  210 QENYEQLVEERHRELREKAQKEEEQFQRA---KWRAEEKEEERQ--EHKEALAELADRKIQQARQ-------VAHKTVQD 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1500 SAAtqlqtkamsfseqttkleeslKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRLRLQAEEEA 1579
Cdd:pfam15558  278 KAQ---------------------RARELNLEREKNHHILKLKVEKEEKCHREGIKEAIKKKEQRSEQISREKEATLEEA 336


                   ....*.
gi 1389908296 1580 QKKSHA 1585
Cdd:pfam15558  337 RKTARA 342
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 1532-1624 2.82e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 40.88  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1532 KLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALrlrlqaeEEAQKKshAQEEAEKQKLEAERDAKK-RGKAEEAA 1610
Cdd:cd06503     34 KIAESLEEAEKAKEEAEELLAEYEEKLAEARAEAQEII-------EEARKE--AEKIKEEILAEAKEEAERiLEQAKAEI 104

                           90
                   ....*....|....
gi 1389908296 1611 LKQKENAEKELDKQ 1624
Cdd:cd06503    105 EQEKEKALAELRKE 118
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 1484-1735 2.83e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 42.89  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1484 EEKIRQIRVVeeVAQKSAATQLQTKAMSFSEQTTklEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQ 1563
Cdd:pfam17045    9 QELMKQIDIM--VAHKKSEWEGQTRALETRLDIR--EEELLSARNTLERKHKEIGLLRQQLEELEKGKQELVAKYEQQLQ 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1564 KANEALRLRLQAEEEAQKKS--HAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQQKLSAEQE 1641
Cdd:pfam17045   85 KLQEELSKLKRSYEKLQRKQlkEAREEAKSREEDRSELSRLNGKLEEFRQKSLEWEQQRLQYQQQVASLEAQRKALAEQS 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1642 CIRLKADF----EHAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLL--QMKINAEKasmvntEKSKQL 1715
Cdd:pfam17045  165 SLIQSAAYqvqlEGRKQCLEASQSEIQRLRSKLERAQDSLCAQELELERLRMRVSELGdsNRKLLEEQ------QRLLEE 238

                          250       260
                   ....*....|....*....|
gi 1389908296 1716 LESEALKMKQLADEAARMRS 1735
Cdd:pfam17045  239 LRMSQRQLQVLQNELMELKA 258
PRK12704 PRK12704
phosphodiesterase; Provisional
 2417-2531 2.84e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2417 LLLKR--EKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKlmeEERKKLQAIMDEAVRKQKE--AEEEMKNKQREmDVL 2492
Cdd:PRK12704    23 FVRKKiaEAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAK---EEIHKLRNEFEKELRERRNelQKLEKRLLQKE-ENL 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1389908296 2493 DKKRLE---QEKQLAEENKKLREQLQTFEISSKTVSQTKESQ 2531
Cdd:PRK12704    99 DRKLELlekREEELEKKEKELEQKQQELEKKEEELEELIEEQ 140
mukB PRK04863
chromosome partition protein MukB;
1335-1676 2.89e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 44.18  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1335 AADAEKQKQNIQQELQHL-KSLSDQEikSKNQQLEDALvsrrkieeeihiiriqlekttahkAKSEAELQELRDRAAEAE 1413
Cdd:PRK04863   832 EADPEAELRQLNRRRVELeRALADHE--SQEQQQRSQL------------------------EQAKEGLSALNRLLPRLN 885

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1414 KL-RKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAK--QKQRALDDLQKYKMQAEEAERRMKQaeeekirQI 1490
Cdd:PRK04863   886 LLaDETLADRVEEIREQLDEAEEAKRFVQQHGNALAQLEPIVSVlqSDPEQFEQLKQDYQQAQQTQRDAKQ-------QA 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1491 RVVEEVAQKSAAtqlqtkaMSFSEQttklEESLKKEQGNVlklqeeaDKLKKQQKEANTAREEAEQELEIWRQKANEALR 1570
Cdd:PRK04863   959 FALTEVVQRRAH-------FSYEDA----AEMLAKNSDLN-------EKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQ 1020

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1571 LR--LQAEEEAQKKSHAQEEAEKQKL------EAERDAKKRGKAEEAALKQKENAEKELDKQRKFAE---QIAQQKLSAE 1639
Cdd:PRK04863  1021 VLasLKSSYDAKRQMLQELKQELQDLgvpadsGAEERARARRDELHARLSANRSRRNQLEKQLTFCEaemDNLTKKLRKL 1100

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1389908296 1640 QEciRLKADFEHAEQQRGLLDNELQRLKNevNSTEKQ 1676
Cdd:PRK04863  1101 ER--DYHEMREQVVNAKAGWCAVLRLVKD--NGVERR 1133
46 PHA02562
endonuclease subunit; Provisional
 1417-1607 2.91e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 2.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1417 KAAQDEAERLRKQVAEETQRKKNAEDELKRKsdaEKEAAKQKQRALDDLQKYKMQAEEAERRMKqaeeeKIRQirvveEV 1496
Cdd:PHA02562   198 KTYNKNIEEQRKKNGENIARKQNKYDELVEE---AKTIKAEIEELTDELLNLVMDIEDPSAALN-----KLNT-----AA 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1497 AQKSAATQLQTKAMSFSEQTT---KLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEIWRQKANEALRL-- 1571
Cdd:PHA02562   265 AKIKSKIEQFQKVIKMYEKGGvcpTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELkn 344

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1389908296 1572 -----------------RLQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAE 1607
Cdd:PHA02562   345 kistnkqslitlvdkakKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSE 397
PRK11637 PRK11637
AmiB activator; Provisional
 2092-2343 2.99e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 43.53  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2092 AEQALQQKSQVEKeltvvkLQLDETDKQKVLLDQELQRvkGEVNDAFKQKSQVEVELAR-VRIQMEELVKLKLKIEEENR 2170
Cdd:PRK11637    39 SAHASDNRDQLKS------IQQDIAAKEKSVRQQQQQR--ASLLAQLKKQEEAISQASRkLRETQNTLNQLNKQIDELNA 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2171 RL--MQKDKDSTQKLLAEEAEKMKSLAEEAG-RLSVEAEETARQRQIaesnLAEQRALAekilkekmQAIQEA-TKLKAE 2246
Cdd:PRK11637   111 SIakLEQQQAAQERLLAAQLDAAFRQGEHTGlQLILSGEESQRGERI----LAYFGYLN--------QARQETiAELKQT 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2247 AEKLQKQKD---QAQETAKRLQEDKQQIQQRLDKETEGFQKSLEAerkrqLEASAEAEK---LKLRVKELSLAQT--KAE 2318
Cdd:PRK11637   179 REELAAQKAeleEKQSQQKTLLYEQQAQQQKLEQARNERKKTLTG-----LESSLQKDQqqlSELRANESRLRDSiaRAE 253

                          250       260       270
                   ....*....|....*....|....*....|
gi 1389908296 2319 DEAK----KFKKQADEVKA-QLQRTEKHTT 2343
Cdd:PRK11637   254 REAKaraeREAREAARVRDkQKQAKRKGST 283
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 4200-4231 3.00e-03

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 38.08  E-value: 3.00e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1389908296 4200 IAGILDTDTLEKVSVTEAIHRNLVDNITGQRL 4231
Cdd:pfam00681    8 TGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 2146-2332 3.09e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 43.66  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2146 VELARVRIQMEELvKLKLKIE--EENRRLMQKDKDSTQKLLaEEAEKMK-SLAEEAGRLSvEAEETARQRQiaesnlaEQ 2222
Cdd:PRK00409   504 IEEAKKLIGEDKE-KLNELIAslEELERELEQKAEEAEALL-KEAEKLKeELEEKKEKLQ-EEEDKLLEEA-------EK 573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2223 RAlaEKILKEkmqAIQEATKLKAEAEKLQKQKDQAQeTAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQL-------- 2294
Cdd:PRK00409   574 EA--QQAIKE---AKKEADEIIKELRQLQKGGYASV-KAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVgdevkyls 647

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 2295 --------------EASAEAEKLKLRVK--ELSLAQTKAEDEAKKFKKQADEVK 2332
Cdd:PRK00409   648 lgqkgevlsipddkEAIVQAGIMKMKVPlsDLEKIQKPKKKKKKKPKTVKPKPR 701
PRK11519 PRK11519
tyrosine-protein kinase Wzc;
1514-1673 3.16e-03

tyrosine-protein kinase Wzc;


Pssm-ID: 183173 [Multi-domain]  Cd Length: 719  Bit Score: 43.60  E-value: 3.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1514 EQTTKLEESLKKE--QGNVLKLQEEADK----LKKQQKEANTAREEAEQELEIWRQKaNEALRLRLQAEE--------EA 1579
Cdd:PRK11519   240 EQIRDILNSITRNylEQNIERKSEEASKslafLAQQLPEVRSRLDVAENKLNAFRQD-KDSVDLPLEAKAvldsmvniDA 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1580 QKKSHAQEEAEKQKLEAerdakKRGKAEEAALKQKENAEKELDKQRKFAEQIAQqklsAEQECIRLKADFEHAEQQRGLL 1659
Cdd:PRK11519   319 QLNELTFKEAEISKLYT-----KEHPAYRTLLEKRKALEDEKAKLNGRVTAMPK----TQQEIVRLTRDVESGQQVYMQL 389

                          170
                   ....*....|....
gi 1389908296 1660 DNELQRLKNEVNST 1673
Cdd:PRK11519   390 LNKQQELKITEAST 403
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 2191-2528 3.20e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 43.52  E-value: 3.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2191 MKSLAEEAGRLSVEAEETARQRQIAESNLAEQRALAEkilkEKMQAIQEATKLKAEAEKLQKQKDQAQ------ETAKRL 2264
Cdd:pfam05622   68 LEQLQEENFRLETARDDYRIKCEELEKEVLELQHRNE----ELTSLAEEAQALKDEMDILRESSDKVKkleatvETYKKK 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2265 QED----KQQIQQRLDKETEGFQK--SLEAERKRQLEASAEAEKLKLRVKELslaQTKAEDEAKKFKKQADEVKaqlQRT 2338
Cdd:pfam05622  144 LEDlgdlRRQVKLLEERNAEYMQRtlQLEEELKKANALRGQLETYKRQVQEL---HGKLSEESKKADKLEFEYK---KLE 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2339 EKHTTeivVQKlETQRLQSTREA-----DDLKSAIADLEEERKKLKkeaeelqrkskeMANAQQEQIEQQKAELQQSFLT 2413
Cdd:pfam05622  218 EKLEA---LQK-EKERLIIERDTlretnEELRCAQLQQAELSQADA------------LLSPSSDPGDNLAAEIMPAEIR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2414 EKGLLLKREKEVEGEKKrfEKQLEDEMKKAKALKDE-QERQRKLMEEERKKLQAIMD--EAVRKQKEAEEEMKNKQREMD 2490
Cdd:pfam05622  282 EKLIRLQHENKMLRLGQ--EGSYRERLTELQQLLEDaNRRKNELETQNRLANQRILElqQQVEELQKALQEQGSKAEDSS 359

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1389908296 2491 VLDKKRLEQEKQLAE---ENKKLREQLQTFEISSKTVSQTK 2528
Cdd:pfam05622  360 LLKQKLEEHLEKLHEaqsELQKKKEQIEELEPKQDSNLAQK 400
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 2388-2555 3.28e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.45  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2388 KSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEgEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAi 2467
Cdd:pfam05262  213 KRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVR-QKQQEAKNLPKPADTSSPKEDKQVAENQKREIEKAQIEI- 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2468 mdeavrkQKEAEEEMKNKQREMDVLDKKRLEQEKQlaEENKKLREQLQTFEISS---KTVSQTKESQTVSVEKLVAVTTV 2544
Cdd:pfam05262  291 -------KKNDEEALKAKDHKAFDLKQESKASEKE--AEDKELEAQKKREPVAEdlqKTKPQVEAQPTSLNEDAIDSSNP 361

                          170
                   ....*....|.
gi 1389908296 2545 GTSKGVLNGST 2555
Cdd:pfam05262  362 VYGLKVVDPIT 372
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1444-1748 3.39e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.41  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1444 LKRKSDAEKEAAKQ----KQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKL 1519
Cdd:COG5185    248 LAQTSDKLEKLVEQntdlRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQEL 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1520 EESLKKEQGNVLKLQEEADKLKKQQKEA-NTAREEAEQELEIWRQKANEALRLRLQAEEEAQKKS-----HAQEEAEKQK 1593
Cdd:COG5185    328 EESKRETETGIQNLTAEIEQGQESLTENlEAIKEEIENIVGEVELSKSSEELDSFKDTIESTKESldeipQNQRGYAQEI 407

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1594 LEAERDAKKRGKAE---------------EAALKQKENAEKELDKQRKFAEQIAQQKLSAEQecirlKADFEHAEQQRGL 1658
Cdd:COG5185    408 LATLEDTLKAADRQieelqrqieqatssnEEVSKLLNELISELNKVMREADEESQSRLEEAY-----DEINRSVRSKKED 482

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1659 LDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEA--LKMKQLADEAARMRSV 1736
Cdd:COG5185    483 LNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENLipASELIQASNAKTDGQA 562

                          330
                   ....*....|..
gi 1389908296 1737 AEEAKKQRQIAE 1748
Cdd:COG5185    563 ANLRTAVIDELT 574
CH_CYTS cd21199
calponin homology (CH) domain found in the cytospin family; The cytospin family includes ...
 111-168 3.40e-03

calponin homology (CH) domain found in the cytospin family; The cytospin family includes cytospin-A and cytospin-B. Cytospin-A, also called renal carcinoma antigen NY-REN-22, sperm antigen with calponin homology and coiled-coil domains 1-like, or SPECC1-like (SPECC1L) protein, is involved in cytokinesis and spindle organization. It may play a role in actin cytoskeleton organization and microtubule stabilization and hence, is required for proper cell adhesion and migration. Cytospin-B, also called nuclear structure protein 5 (NSP5), sperm antigen HCMOGT-1, or sperm antigen with calponin homology and coiled-coil domains 1 (SPECC1), is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with translocation t(5;17)(q33;p11.2). Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409048  Cd Length: 112  Bit Score: 40.04  E-value: 3.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296  111 PALIDMNQVYRQSNQENLEQAFSVAErELGVTKLLDPED-VDVPHPDEKSIITYVSSLY 168
Cdd:cd21199     51 PDKIPYSELNPQDKRRNFTLAFKAAE-SVGIPTTLTIDEmVSMERPDWQSVMSYVTAIY 108
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 2075-2538 3.48e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2075 LKQKQQADAEmsKHKKEAEQALQQKSQVEKELTVVKLQLD-------ETDKQKVLLDQELQRVKGEVNDAF-KQKSQVEV 2146
Cdd:pfam12128  331 HGAFLDADIE--TAAADQEQLPSWQSELENLEERLKALTGkhqdvtaKYNRRRSKIKEQNNRDIAGIKDKLaKIREARDR 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2147 ELARVRIQMEELvklklkiEEENRRLMQKDKDStqklLAEEAEKMKS-LAEEAGRLS--VEAEETARQRQIAESNLAEQR 2223
Cdd:pfam12128  409 QLAVAEDDLQAL-------ESELREQLEAGKLE----FNEEEYRLKSrLGELKLRLNqaTATPELLLQLENFDERIERAR 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2224 ALAEKILKEKMQAIQEATKLKA----EAEKLQKQKDQAQETAKRLQEDKQQIQQR-------LDKETEGFQKSLEAERKR 2292
Cdd:pfam12128  478 EEQEAANAEVERLQSELRQARKrrdqASEALRQASRRLEERQSALDELELQLFPQagtllhfLRKEAPDWEQSIGKVISP 557

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2293 QL-----------EASAEAEK----LKLRVKEL----SLAQTKA-EDEAKKFKKQADEVKAQLQRTEKHTTEIVVQkLET 2352
Cdd:pfam12128  558 ELlhrtdldpevwDGSVGGELnlygVKLDLKRIdvpeWAASEEElRERLDKAEEALQSAREKQAAAEEQLVQANGE-LEK 636

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2353 QRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKE---MANAQQEQIEQQK-----------AELQQSFLTEKGLL 2418
Cdd:pfam12128  637 ASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAErkdSANERLNSLEAQLkqldkkhqawlEEQKEQKREARTEK 716

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2419 LKREKEVEGEKKRFEKQLEDEMKKAKALKD------EQERQRKL------------MEEERKKLQAIMDEAVRKQKEAEE 2480
Cdd:pfam12128  717 QAYWQVVEGALDAQLALLKAAIAARRSGAKaelkalETWYKRDLaslgvdpdviakLKREIRTLERKIERIAVRRQEVLR 796

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 2481 EMKNKQREMDVLDKKRLEQEKQLAEENKKLREQLQTFEISSKTVSQTKESQTVSVEKL 2538
Cdd:pfam12128  797 YFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQ 854
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 1437-1549 3.70e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 40.31  E-value: 3.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1437 KKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERR-----MKQAEE-EKIRQIRvvEEVAQ-KSAATQLQTKA 1509
Cdd:pfam07926    3 LSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNyerelVLHAEDiKALQALR--EELNElKAEIAELKAEA 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1389908296 1510 MSFSEQTTKLEESLKKEQGnvlKLQEEADKLKKQQKEANT 1549
Cdd:pfam07926   81 ESAKAELEESEESWEEQKK---ELEKELSELEKRIEDLNE 117
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
 1325-1639 3.77e-03

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 43.13  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1325 KEEASKRQDVAADAEKQKQNIQQEL-----------QHLKSLSDQEIKSKNQQLEDALVSRRKIEEEIHIIRIQLEKTTA 1393
Cdd:pfam04747   14 QQLTNRRKNLGRVAKSQRNQFRQWLltavlpnsindQRKEAFASLELTEQPQQVEKVKKSEKKKAQKQIAKDHEAEQKVN 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1394 HKAKSEAELqelrdRAAEAEKLRKAAQdeaerlrkqvaEETQRKKNAEDELKRKSDAEKEAAKQKQRAlddlQKYKMQAE 1473
Cdd:pfam04747   94 AKKAAEKEA-----RRAEAEAKKRAAQ-----------EEEHKQWKAEQERIQKEQEKKEADLKKLQA----EKKKEKAV 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1474 EAERRMKQAEEEKIRQIRVVEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREE 1553
Cdd:pfam04747  154 KAEKAEKAEKTKKASTPAPVEEEIVVKKVANDRSAAPAPEPKTPTNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPAS 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1554 AEQELEIWRQKANEALRlrlQAEEEAQKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQ 1633
Cdd:pfam04747  234 VEQVVEQPKVVTEEPHQ---QAAPQEKKNKKNKRKSESENVPAASETPVEPVVETTPPASENQKKNKKDKKKSESEKVVE 310


                   ....*.
gi 1389908296 1634 QKLSAE 1639
Cdd:pfam04747  311 EPVQAE 316
SPFH_like_u3 cd03406
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 1389-1488 3.80e-03

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259804 [Multi-domain]  Cd Length: 293  Bit Score: 42.67  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1389 EKTtahKAKSEAELQELRDRAAEAEklRKAAQDEAERLRkQVAEETQRKKNAEDE-LKRKSDAEKEAAKQKQRALDDLQK 1467
Cdd:cd03406    174 EKT---KLLIAEQHQKVVEKEAETE--RKRAVIEAEKDA-EVAKIQMQQKIMEKEaEKKISEIEDEMHLAREKARADAEY 247

                           90       100
                   ....*....|....*....|.
gi 1389908296 1468 YKMqaeeaerrMKQAEEEKIR 1488
Cdd:cd03406    248 YRA--------LREAEANKLK 260
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1389-1594 3.91e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.88  E-value: 3.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1389 EKT--TAHKAKSEAELQELRdRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQ 1466
Cdd:pfam15905  116 EKTslSASVASLEKQLLELT-RVNELLKAKFSEDGTQKKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLE 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1467 KYKMQAEEAERRMKQAEEEKIRQ----IRVVEEVAQKSAATQlqtKAMSFSEQTTKLEESLKKEQGNVL----KLQEEAD 1538
Cdd:pfam15905  195 HSKGKVAQLEEKLVSTEKEKIEEksetEKLLEYITELSCVSE---QVEKYKLDIAQLEELLKEKNDEIEslkqSLEEKEQ 271

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 1539 KLKKQQKEANTAREEAEQELEIWRQKaNEALRLRLQAEEEAQKKSHAQEEAEKQKL 1594
Cdd:pfam15905  272 ELSKQIKDLNEKCKLLESEKEELLRE-YEEKEQTLNAELEELKEKLTLEEQEHQKL 326
PRK12705 PRK12705
hypothetical protein; Provisional
 1402-1602 3.96e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 43.16  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1402 LQELRDRAAEAEKLRKAAQDEAERLRKQVaeetqrkknaedELKRKSDAEKEAAKQKQRALDDLQKYKmqaeEAERRMKQ 1481
Cdd:PRK12705    25 LKKRQRLAKEAERILQEAQKEAEEKLEAA------------LLEAKELLLRERNQQRQEARREREELQ----REEERLVQ 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1482 AEEekirqirvveevaqksaatQLQTKAmsfsEQTTKLEEslkkeqgnvlKLQEEADKLKKQQKEANTAREEAEQELE-- 1559
Cdd:PRK12705    89 KEE-------------------QLDARA----EKLDNLEN----------QLEEREKALSARELELEELEKQLDNELYrv 135

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1389908296 1560 --IWRQKANEALRLRLQAEEEAQKKSHAQEEAEKQKLEAERDAKK 1602
Cdd:PRK12705   136 agLTPEQARKLLLKLLDAELEEEKAQRVKKIEEEADLEAERKAQN 180
PRK12705 PRK12705
hypothetical protein; Provisional
 1742-1888 4.24e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 43.16  E-value: 4.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1742 KQRQIAEEEAARQRSEAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAYQRK------------LLED 1809
Cdd:PRK12705    26 KKRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQREEERLVQKeeqldaraekldNLEN 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1810 Q---AAQHKQDIEEKITQLQTSSDSELGRQKNIVEETLKQK--KVVEEEIHIIKINFHKASKEKADLESELKKLKGIADE 1884
Cdd:PRK12705   106 QleeREKALSARELELEELEKQLDNELYRVAGLTPEQARKLllKLLDAELEEEKAQRVKKIEEEADLEAERKAQNILAQA 185


                   ....
gi 1389908296 1885 TQKS 1888
Cdd:PRK12705   186 MQRI 189
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 2185-2451 4.26e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 43.40  E-value: 4.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2185 AEEAEKMKslAEEAgRLSVEAEEtARQRQIAESNLAEQRALAEKILKEKMQAIQEA-----TKLKAEAEKLQKQKDQAQE 2259
Cdd:PRK05035   440 AIEQEKKK--AEEA-KARFEARQ-ARLEREKAAREARHKKAAEARAAKDKDAVAAAlarvkAKKAAATQPIVIKAGARPD 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2260 TAKRLQEDKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTE 2339
Cdd:PRK05035   516 NSAVIAAREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKKAA 595

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2340 KHTTEIVVQKLETqrlqstrEADDLKSAIAdleeerkkLKKEAEELQRKSKEMANAQQEQIEQQKAELQ------QSFLT 2413
Cdd:PRK05035   596 QQAASAEPEEQVA-------EVDPKKAAVA--------AAIARAKAKKAEQQANAEPEEPVDPRKAAVAaaiaraKARKA 660

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1389908296 2414 EKGLLLKREKEVEGEKKrfeKQLEDEMKKAKALKDEQE 2451
Cdd:PRK05035   661 AQQQANAEPEEAEDPKK---AAVAAAIARAKAKKAAQQ 695
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 2176-2363 4.31e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.07  E-value: 4.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2176 DKDSTQKLLaEEAEKMKSLAEEAGRL-SVEAEETARQRQIAESNLAEQRALAEKilkekmqAIQEATKLKAEAEKLQKQK 2254
Cdd:pfam05262  179 DKKVVEALR-EDNEKGVNFRRDMTDLkERESQEDAKRAQQLKEELDKKQIDADK-------AQQKADFAQDNADKQRDEV 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2255 DQAQETAKRLqEDKQQIQQRLDKETEGFQKSLEAErKRQLEASAEAEKLKlrvKELSLAQTKAEDEAKKFKKQADEVKAQ 2334
Cdd:pfam05262  251 RQKQQEAKNL-PKPADTSSPKEDKQVAENQKREIE-KAQIEIKKNDEEAL---KAKDHKAFDLKQESKASEKEAEDKELE 325

                          170       180
                   ....*....|....*....|....*....
gi 1389908296 2335 LQRTEKHTTEIVVQKLETQRLQSTREADD 2363
Cdd:pfam05262  326 AQKKREPVAEDLQKTKPQVEAQPTSLNED 354
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1500-1759 4.56e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 4.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1500 SAATQLQTKAmsfsEQTTKLEESLKKEQGNVLKLQEEADKLKKQQKEANTAREEAEQELEiwrqkanealrlrlQAEEEA 1579
Cdd:COG3883     13 FADPQIQAKQ----KELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEID--------------KLQAEI 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1580 QKKSHAQEEAEKQKLEAERDAKKRGKAE------------EAALKQKENAEKELDKQRKFAEQIAQQKLSAEQEcirlKA 1647
Cdd:COG3883     75 AEAEAEIEERREELGERARALYRSGGSVsyldvllgsesfSDFLDRLSALSKIADADADLLEELKADKAELEAK----KA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1648 DfehAEQQRGLLDNELQRLKNEVNSTEKQRKQLEDELNKVRSEMDSLLQMKINAEKASMVNTEKSKQLLESEALKMKQLA 1727
Cdd:COG3883    151 E---LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAA 227

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1389908296 1728 DEAARMRSVAEEAKKQRQIAEEEAARQRSEAE 1759
Cdd:COG3883    228 AAAAAAAAAAAAAAAAASAAGAGAAGAAGAAA 259
PRK07735 PRK07735
NADH-quinone oxidoreductase subunit C;
1267-1527 4.72e-03

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 236081 [Multi-domain]  Cd Length: 430  Bit Score: 43.05  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1267 AQRRLEDDEKASE-KLKEEERRKMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKMKMKEEASKRQDVAADAEKQKqni 1345
Cdd:PRK07735    28 AKHGAEISKLEEEnREKEKALPKNDDMTIEEAKRRAAAAAKAKAAALAKQKREGTEEVTEEEKAKAKAKAAAAAKAK--- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1346 QQELQHLKSLSDQEIKSknqqlEDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEAEKLRKAAQDEAER 1425
Cdd:PRK07735   105 AAALAKQKREGTEEVTE-----EEKAAAKAKAAAAAKAKAAALAKQKREGTEEVTEEEEETDKEKAKAKAAAAAKAKAAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1426 LRKQVAEEtqrkknAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRVVEEVAQKSAATQL 1505
Cdd:PRK07735   180 LAKQKAAE------AGEGTEEVTEEEKAKAKAKAAAAAKAKAAALAKQKASQGNGDSGDEDAKAKAIAAAKAKAAAAARA 253

                          250       260
                   ....*....|....*....|..
gi 1389908296 1506 QTKAMSFSEQTTKLEESLKKEQ 1527
Cdd:PRK07735   254 KTKGAEGKKEEEPKQEEPSVNQ 275
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 2386-2506 4.96e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.61  E-value: 4.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2386 QRKSKEMANAQQEQIEQQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQERQrKLMEEERKKLQ 2465
Cdd:pfam13904   67 QRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKSLAKPERK-VSQEEAKEVLQ 145

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1389908296 2466 AIMDEAVRKQKEAEEEMKNKQREmdvldKKRLEQE-KQLAEE 2506
Cdd:pfam13904  146 EWERKKLEQQQRKREEEQREQLK-----KEEEEQErKQLAEK 182
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1413-1590 5.12e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 42.68  E-value: 5.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1413 EKLRKAAQDEAERLRkqvaEETQRKKNAEDELKRKSDAEKEAAKQKQRALDDLQKYKMQAEEAERRMKQAEEEKIRQIRV 1492
Cdd:pfam05262  184 EALREDNEKGVNFRR----DMTDLKERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAKN 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1493 VEEVAQKSAATQLQTKAMSFSEQTTKLEESLKKEQGNVLKLQEE-ADKLKKQQKEANTAREEAEQELEIWRQKANEALRl 1571
Cdd:pfam05262  260 LPKPADTSSPKEDKQVAENQKREIEKAQIEIKKNDEEALKAKDHkAFDLKQESKASEKEAEDKELEAQKKREPVAEDLQ- 338

                          170
                   ....*....|....*....
gi 1389908296 1572 RLQAEEEAQKKSHAQEEAE 1590
Cdd:pfam05262  339 KTKPQVEAQPTSLNEDAID 357
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 2347-2514 5.14e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2347 VQKLETQRLQSTREADDLKSAIADLEEERKKLKKEAEELQRKSKEmANAQQEQIEQQKAELQQSFLTEKGLLLK----RE 2422
Cdd:COG1579     12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELED-LEKEIKRLELEIEEVEARIKKYEEQLGNvrnnKE 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2423 -----KEVEGEKKRfEKQLEDEMKKAKALKDEQERQRKLMEEERKKLQAIMDEavrKQKEAEEEMKNKQREMDVLDKKRL 2497
Cdd:COG1579     91 yealqKEIESLKRR-ISDLEDEILELMERIEELEEELAELEAELAELEAELEE---KKAELDEELAELEAELEELEAERE 166

                          170
                   ....*....|....*..
gi 1389908296 2498 EQEKQLAEENKKLREQL 2514
Cdd:COG1579    167 ELAAKIPPELLALYERI 183
PLEC smart00250
Plectin repeat;
3922-3953 5.51e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 5.51e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1389908296  3922 KLVSAERAVTGYKDPYSGKVISLFQAMKKGLI 3953
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
2204-2340 5.52e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 42.55  E-value: 5.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2204 EAEETARQrQIAESN--LAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQK------DQA---QETAKRLQEDKQQIQ 2272
Cdd:COG2268    207 EAERETEI-AIAQANreAEEAELEQEREIETARIAEAEAELAKKKAEERREAEtaraeaEAAyeiAEANAEREVQRQLEI 285

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1389908296 2273 QRLDKETEGFQKSLEAERKRQ---LEASAEAEKLKLRVKEL-----SLAQTKAEDEAKKFKKQADEVKAQLQRTEK 2340
Cdd:COG2268    286 AEREREIELQEKEAEREEAELeadVRKPAEAEKQAAEAEAEaeaeaIRAKGLAEAEGKRALAEAWNKLGDAAILLM 361
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 2075-2514 6.35e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.89  E-value: 6.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2075 LKQKQQADAEMSKHKKEAEQALQQKSQVEKELTvvklQLDETDKQKVLLDQELQRVKGEVNDAFKQKSQVEV-----ELA 2149
Cdd:pfam10174   58 LKEQYRVTQEENQHLQLTIQALQDELRAQRDLN----QLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHerqakELF 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2150 RVRIQMEELvklKLKIEEENRRLMQKDkDSTQKLLaeEAEKMKSLAEEAGrlsVEAEETARQRQIAESNLAEQRALAEKI 2229
Cdd:pfam10174  134 LLRKTLEEM---ELRIETQKQTLGARD-ESIKKLL--EMLQSKGLPKKSG---EEDWERTRRIAEAEMQLGHLEVLLDQK 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2230 LKEKMQAiqeatklkaeAEKLQKQKDQAQETAKrlqedKQQIQQRLD-KETegfqKSLEAERK-RQLEASAEAEK----L 2303
Cdd:pfam10174  205 EKENIHL----------REELHRRNQLQPDPAK-----TKALQTVIEmKDT----KISSLERNiRDLEDEVQMLKtnglL 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2304 KLRVKELSLAQTKAEDEAKKF-KKQADEVKAQLQRTEkhtTEIVV--QKLET---QRLQSTREADDLKSAIA--DLEEER 2375
Cdd:pfam10174  266 HTEDREEEIKQMEVYKSHSKFmKNKIDQLKQELSKKE---SELLAlqTKLETltnQNSDCKQHIEVLKESLTakEQRAAI 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2376 KKLKKEAEELQRKSKE-MANAQQEQIE---QQKAELQQSFLTEKGLLLKREKEVEGEKKRFEKQLEDEMKKAKALKDEQE 2451
Cdd:pfam10174  343 LQTEVDALRLRLEEKEsFLNKKTKQLQdltEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKE 422

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1389908296 2452 RQRKLMEEERKKLQAI--MDEAVRKQKEAEEEMKnKQREMDvlDKKRLEQEKQLAEENKKLREQL 2514
Cdd:pfam10174  423 RVKSLQTDSSNTDTALttLEEALSEKERIIERLK-EQRERE--DRERLEELESLKKENKDLKEKV 484
SPFH_like_u3 cd03406
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 2154-2257 6.50e-03

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259804 [Multi-domain]  Cd Length: 293  Bit Score: 41.90  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2154 QMEElVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEEAGRLSVEAEETARQRQI--AESNLAEQRALAE---- 2227
Cdd:cd03406    170 AMEA-EKTKLLIAEQHQKVVEKEAETERKRAVIEAEKDAEVAKIQMQQKIMEKEAEKKISEieDEMHLAREKARADaeyy 248

                           90       100       110
                   ....*....|....*....|....*....|
gi 1389908296 2228 KILKEKmqaiqEATKLKAEAEKLQKQKDQA 2257
Cdd:cd03406    249 RALREA-----EANKLKLTPEYLELKKYQA 273
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 2422-2489 6.75e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 39.87  E-value: 6.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1389908296 2422 EKEVEGEKKRFEKQLEDEMKKAKALKDEQERQRKLMEEERKK----LQAIMDEAVRKQKEAEEEMKNKQREM 2489
Cdd:pfam03938   21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEkeqeLQKKEQELQQLQQKAQQELQKKQQEL 92
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1501-1633 6.77e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 42.76  E-value: 6.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1501 AATQLQTKAMSFSEQTTKLEESLKKeqgnvlkLQEEADKLKKQQKEANTAR-EEAEQELEIWRQKANEalrlrLQAEEEA 1579
Cdd:COG0542    398 AAARVRMEIDSKPEELDELERRLEQ-------LEIEKEALKKEQDEASFERlAELRDELAELEEELEA-----LKARWEA 465

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1389908296 1580 QKKSHAQEEAEKQKLEAERDAKKRGKAEEAALKQKENAEKELDKQRKFAEQIAQ 1633
Cdd:COG0542    466 EKELIEEIQELKEELEQRYGKIPELEKELAELEEELAELAPLLREEVTEEDIAE 519
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 1757-1896 6.89e-03

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 42.74  E-value: 6.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1757 EAEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKrqaeeeayqrkllEDQAAQHKQDIEEKITQLQTSSDSELGRQ 1836
Cdd:TIGR00422  721 EAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYT-------------EAETAERLKLNAVDIKGAINFSEVEVVIE 787

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1837 KNIVEETLkQKKVVEEEIHIIKINFHKASKEKADLESELKKLKGiadETQKSKLKAEEEA 1896
Cdd:TIGR00422  788 KPEVTEAV-VELVPGFEIIIPVKGLINKAKELARLQKQLDKEKK---EVIRIEGKLENEG 843
PRK07352 PRK07352
F0F1 ATP synthase subunit B; Validated
 1540-1669 7.14e-03

F0F1 ATP synthase subunit B; Validated


Pssm-ID: 180941 [Multi-domain]  Cd Length: 174  Bit Score: 40.71  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1540 LKKQQKEANTAREEAEQELeiwrQKANEALrlrlqaEEEAQKKSHAQEEAEKQKLEAERDAK-------KRGKAEEAALK 1612
Cdd:PRK07352    48 LEERREAILQALKEAEERL----RQAAQAL------AEAQQKLAQAQQEAERIRADAKARAEairaeieKQAIEDMARLK 117

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1389908296 1613 QKENAEKELDKQRKFAE---QIAQQKLS-AEQEcirLKADFEHAEQQRgLLDNELQRLKNE 1669
Cdd:PRK07352   118 QTAAADLSAEQERVIAQlrrEAAELAIAkAESQ---LPGRLDEDAQQR-LIDRSIANLGGN 174
PRK01156 PRK01156
chromosome segregation protein; Provisional
 990-1467 8.04e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.58  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296  990 LRSELDLTLKKMEQVYGLSSVYLDKLKTVDVVIRNTADAEETLKNYEARLRDV-SKVPSEQKEVEKHRS-QMKSMRSEAE 1067
Cdd:PRK01156   209 DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAeSDLSMELEKNNYYKElEERHMKIIND 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1068 ADQVMFDRLQDDLRKATTVHDKmTRIHSERDADLEHYRQLVNGL---------LERWQAVFAQIELRLRELDLLGRHMNS 1138
Cdd:PRK01156   289 PVYKNRNYINDYFKYKNDIENK-KQILSNIDAEINKYHAIIKKLsvlqkdyndYIKKKSRYDDLNNQILELEGYEMDYNS 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1139 YRDSYEWLIRWLTEARQRQEKIQAvPISDSRALREQLTDE-KKLLGEIEKNKDKIDDCHKNAKAYIDSVKDYEFQILTYK 1217
Cdd:PRK01156   368 YLKSIESLKKKIEEYSKNIERMSA-FISEILKIQEIDPDAiKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNM 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1218 A-LQDPIASPLKKPKM-ECASDDIIQEYVNLRTRYSELMTLTNQYIKFIIDAQRRLEDDEK--ASEKLKE--EERRKMAE 1291
Cdd:PRK01156   447 EmLNGQSVCPVCGTTLgEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEylESEEINKsiNEYNKIES 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1292 IQAEL----DKQKQMAEAHAKSVAKAEQ------EALELK-------------------MKMKEEASKRQDvaaDAEKQK 1342
Cdd:PRK01156   527 ARADLedikIKINELKDKHDKYEEIKNRykslklEDLDSKrtswlnalavislidietnRSRSNEIKKQLN---DLESRL 603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1343 QNIQQELQHLKSLSDQEIKSKNQQLeDALVSRRKIEEEIHIIRIQLEKTTAHKAKSEAELQELRDRAAEA---------- 1412
Cdd:PRK01156   604 QEIEIGFPDDKSYIDKSIREIENEA-NNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEItsrindiedn 682

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1389908296 1413 -EKLRKAAQD-EAERLRKQVAEETQRKKNAEDElKRKSDAEK--EAAKQKQRALDDLQK 1467
Cdd:PRK01156   683 lKKSRKALDDaKANRARLESTIEILRTRINELS-DRINDINEtlESMKKIKKAIGDLKR 740
Caldesmon pfam02029
Caldesmon;
1727-2057 8.23e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.16  E-value: 8.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1727 ADEAARMRSVAEEAKKQRQIAEEEAARQRSE----AEKILKEKLAAINEATRLKTEAEMALKAKEAENERLKRQAEEEAY 1802
Cdd:pfam02029    4 EEEAARERRRRAREERRRQKEEEEPSGQVTEsvepNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLQEAL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1803 QR-KLLEDQAAQHKQDIEEKITQLQTSSDSELGRQKNIVEEtlkQKKVVEEEIHIIKINFHKASKEKADLESElkklkgi 1881
Cdd:pfam02029   84 ERqKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSR---LGRYKEEETEIREKEYQENKWSTEVRQAE------- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1882 aDETQKSKLKAEEEAEKLKklaaeeerrRKEAEEKVKRITAAEEEAARQCKAAQEEVERLKKKAEDANKQKEKAEKEAEK 1961
Cdd:pfam02029  154 -EEGEEEEDKSEEAEEVPT---------ENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTT 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1962 QVVLAKEAAQKCTAAEQKAQDVLSKNKEDVLA--QEKLRDEFENAKKLAQEAEKAKEKAEKEAALLRQKAEEAEKQKKAA 2039
Cdd:pfam02029  224 KRRQGGLSQSQEREEEAEVFLEAEQKLEELRRrrQEKESEEFEKLRQKQQEAELELEELKKKREERRKLLEEEEQRRKQE 303

                          330
                   ....*....|....*...
gi 1389908296 2040 EneaaKQAKAQNDTEKQR 2057
Cdd:pfam02029  304 E----AERKLREEEEKRR 317
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1674-1826 8.33e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 42.30  E-value: 8.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1674 EKQRKQLEDELNKVRSEMD-SLLQMKINAEKASMVNTEKSKQLLESEALKMK-QLADEAA-RMRSVAEEAKKQRQIAEEE 1750
Cdd:pfam05262  184 EALREDNEKGVNFRRDMTDlKERESQEDAKRAQQLKEELDKKQIDADKAQQKaDFAQDNAdKQRDEVRQKQQEAKNLPKP 263

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1389908296 1751 AARQRSEAEKILKEKLAAINEATRLKTE--AEMALKAKEAENERLKRQAEEeayQRKLLEDQAAQHKQDIEEKITQLQ 1826
Cdd:pfam05262  264 ADTSSPKEDKQVAENQKREIEKAQIEIKknDEEALKAKDHKAFDLKQESKA---SEKEAEDKELEAQKKREPVAEDLQ 338
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1539-1803 8.56e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 8.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1539 KLKKQQKEANTAREEAEQEL----EIWRQKANEALRLRLQAE--EEAQKKSHA-----QEEAEKQKLEAERDAKKRGKAE 1607
Cdd:COG3206    104 NLDEDPLGEEASREAAIERLrknlTVEPVKGSNVIEISYTSPdpELAAAVANAlaeayLEQNLELRREEARKALEFLEEQ 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1608 EAALKQK-ENAEKELDKQRK---------FAEQIAQQKLSAEQECIRLKADFEHAEQQRGLLDNELQRLKNEVNSTEKQR 1677
Cdd:COG3206    184 LPELRKElEEAEAALEEFRQknglvdlseEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSP 263

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1678 --KQLEDELNKVRSEMDSLLQmKINAEKASMVNTEKSKQLLEsealkmKQLADEAARmrsVAEEAKKQRQIAEEEAARQR 1755
Cdd:COG3206    264 viQQLRAQLAELEAELAELSA-RYTPNHPDVIALRAQIAALR------AQLQQEAQR---ILASLEAELEALQAREASLQ 333

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1756 SEAEKiLKEKLAAINEatrlkteaemalkaKEAENERLKRQAE--EEAYQ 1803
Cdd:COG3206    334 AQLAQ-LEARLAELPE--------------LEAELRRLEREVEvaRELYE 368
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1288-1467 8.82e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 8.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1288 KMAEIQAELDKQKQMAEAHAKSVAKAEQEALELKmkmkEEASKRQDVAADAEKQKQNIQQELQHLKSLsdqeIKSKNQQL 1367
Cdd:COG1579     11 DLQELDSELDRLEHRLKELPAELAELEDELAALE----ARLEAAKTELEDLEKEIKRLELEIEEVEAR----IKKYEEQL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1368 EDALVSRrkieeeihiIRIQLEKttahkakseaELQELRDRAAEAEKLRKAAQDEAERLRKQVAEETQRKKNAEDELKRK 1447
Cdd:COG1579     83 GNVRNNK---------EYEALQK----------EIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEK 143

                          170       180
                   ....*....|....*....|
gi 1389908296 1448 SDAEKEAAKQKQRALDDLQK 1467
Cdd:COG1579    144 KAELDEELAELEAELEELEA 163
PLEC smart00250
Plectin repeat;
4343-4380 9.19e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 36.69  E-value: 9.19e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1389908296  4343 QKLRDVSAYSKYLTCPKTKLKISYKDAMERSMTEEGTG 4380
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 2123-2355 9.20e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.13  E-value: 9.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2123 LDQELQRVKGEVNDAFKQKSQVEVELARVRIQ-----MEELVKLkLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAEE 2197
Cdd:PRK04778   254 IEKEIQDLKEQIDENLALLEELDLDEAEEKNEeiqerIDQLYDI-LEREVKARKYVEKNSDTLPDFLEHAKEQNKELKEE 332

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2198 AGRLS----VEAEETARQRQIaESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKLQKQKDQAQETAKRLQEDKQQI-- 2271
Cdd:PRK04778   333 IDRVKqsytLNESELESVRQL-EKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIEKEQEKLSEMLQGLrk 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2272 -QQRLDKETEGFQKSLEaERKRQLEASA-----EAEKLKLRVKELSLAQTKAEDEAKKF-----KKQADEVKAQLQRTEK 2340
Cdd:PRK04778   412 dELEAREKLERYRNKLH-EIKRYLEKSNlpglpEDYLEMFFEVSDEIEALAEELEEKPInmeavNRLLEEATEDVETLEE 490

                          250
                   ....*....|....*
gi 1389908296 2341 HTTEIVVQKLETQRL 2355
Cdd:PRK04778   491 ETEELVENATLTEQL 505
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
 1967-2349 9.80e-03

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 41.97  E-value: 9.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 1967 KEAAQKCTAAEQKAQDVLSKNKEDVLAQEKLRDEFENAKKLAQEAEKAKEKaekeaallrqKAEEAEKQKKAAENEAAKQ 2046
Cdd:pfam04747   52 KEAFASLELTEQPQQVEKVKKSEKKKAQKQIAKDHEAEQKVNAKKAAEKEA----------RRAEAEAKKRAAQEEEHKQ 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2047 AKAqndtEKQRKEAEEEAARRAAAEAAALKQKQQADAEMSKHKKEAEQALQQKSQVEKELTVVKLQLDET---------- 2116
Cdd:pfam04747  122 WKA----EQERIQKEQEKKEADLKKLQAEKKKEKAVKAEKAEKAEKTKKASTPAPVEEEIVVKKVANDRSaapapepktp 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2117 DKQKVLLDQELQRVKGEVNDAFKQKSQVEVELARVRIQmEELVKLKLKIEEENRRLMQKDKDSTQKLLAEEAEKMKSLAE 2196
Cdd:pfam04747  198 TNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPASVE-QVVEQPKVVTEEPHQQAAPQEKKNKKNKRKSESENVPAASE 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2197 EAGRLSVEAEETARQRQiAESNLAEQRALAEKILKEKMQAIQEATKLKAEAEKL---------QKQKDQAQET-AKRLQE 2266
Cdd:pfam04747  277 TPVEPVVETTPPASENQ-KKNKKDKKKSESEKVVEEPVQAEAPKSKKPTADDNMdfldfvtakEEPKDEPAETpAAPVEE 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389908296 2267 DKQQIQQRLDKETEGFQKSLEAERKRQLEASAEAEKLKLRVKELSLAQTKAEDEAKKFKKQADEVKAQLQRTEKHTTEIV 2346
Cdd:pfam04747  356 VVENVVENVVEKSTTPPATENKKKNKKDKKKSESEKVTEQPVESAPAPPQVEQVVETTPPASENKKKNKKDKKKSESEKA 435


                   ...
gi 1389908296 2347 VQK 2349
Cdd:pfam04747  436 VEE 438
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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