mediator of RNA polymerase II transcription subunit 27 isoform X1 [Bos taurus]
Protein Classification
mediator of RNA polymerase II transcription subunit 27( domain architecture ID 10569016)
mediator of RNA polymerase II transcription subunit 27 (Med27) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Med27 | pfam11571 | Mediator complex subunit 27; Mediator is a large complex of up to 33 proteins that is ... |
226-295 | 7.85e-28 | ||
Mediator complex subunit 27; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells. : Pssm-ID: 463298 Cd Length: 85 Bit Score: 103.14 E-value: 7.85e-28
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| Name | Accession | Description | Interval | E-value | ||
| Med27 | pfam11571 | Mediator complex subunit 27; Mediator is a large complex of up to 33 proteins that is ... |
226-295 | 7.85e-28 | ||
Mediator complex subunit 27; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells. Pssm-ID: 463298 Cd Length: 85 Bit Score: 103.14 E-value: 7.85e-28
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| Name | Accession | Description | Interval | E-value | ||
| Med27 | pfam11571 | Mediator complex subunit 27; Mediator is a large complex of up to 33 proteins that is ... |
226-295 | 7.85e-28 | ||
Mediator complex subunit 27; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells. Pssm-ID: 463298 Cd Length: 85 Bit Score: 103.14 E-value: 7.85e-28
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