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Conserved domains on  [gi|1387253737|ref|XP_024843391|]
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EF-hand calcium-binding domain-containing protein 4A isoform X2 [Bos taurus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
57-146 2.04e-08

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 52.49  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  57 APGAGEAQEEEgWEHGRTSGPLATMLEQAQELFLLCDKEAKGFITRHDLQGLQSDLPLTPEQLEAVFESLDQAHTGFLTA 136
Cdd:COG5126    44 TDGDGRISREE-FVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEADELFARLDTDGDGKISF 122

                          90
                  ....*....|
gi 1387253737 137 REFCLGLGKF 146
Cdd:COG5126   123 EEFVAAVRDY 132
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
57-146 2.04e-08

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 52.49  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  57 APGAGEAQEEEgWEHGRTSGPLATMLEQAQELFLLCDKEAKGFITRHDLQGLQSDLPLTPEQLEAVFESLDQAHTGFLTA 136
Cdd:COG5126    44 TDGDGRISREE-FVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEADELFARLDTDGDGKISF 122

                          90
                  ....*....|
gi 1387253737 137 REFCLGLGKF 146
Cdd:COG5126   123 EEFVAAVRDY 132
PRK12309 PRK12309
transaldolase;
85-144 1.22e-05

transaldolase;


Pssm-ID: 183426 [Multi-domain]  Cd Length: 391  Bit Score: 47.04  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  85 AQELFLLCDKEAKGFITRHDLQGlqSDlpltpeqleAVFESLDQAHTGFLTAREFCLGLG 144
Cdd:PRK12309  336 AQEIFRLYDLDGDGFITREEWLG--SD---------AVFDALDLNHDGKITPEEMRAGLG 384
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 86-143 5.16e-03

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 35.27  E-value: 5.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  86 QELFLLCDKEAKGFITRHDLQG--LQSDLPltPEQLEAVFESLDQAHTGFLTAREFCLGL 143
Cdd:cd00052     2 DQIFRSLDPDGDGLISGDEARPflGKSGLP--RSVLAQIWDLADTDKDGKLDKEEFAIAM 59
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
57-146 2.04e-08

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 52.49  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  57 APGAGEAQEEEgWEHGRTSGPLATMLEQAQELFLLCDKEAKGFITRHDLQGLQSDLPLTPEQLEAVFESLDQAHTGFLTA 136
Cdd:COG5126    44 TDGDGRISREE-FVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEADELFARLDTDGDGKISF 122

                          90
                  ....*....|
gi 1387253737 137 REFCLGLGKF 146
Cdd:COG5126   123 EEFVAAVRDY 132
PRK12309 PRK12309
transaldolase;
85-144 1.22e-05

transaldolase;


Pssm-ID: 183426 [Multi-domain]  Cd Length: 391  Bit Score: 47.04  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  85 AQELFLLCDKEAKGFITRHDLQGlqSDlpltpeqleAVFESLDQAHTGFLTAREFCLGLG 144
Cdd:PRK12309  336 AQEIFRLYDLDGDGFITREEWLG--SD---------AVFDALDLNHDGKITPEEMRAGLG 384
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 86-143 5.16e-03

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 35.27  E-value: 5.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253737  86 QELFLLCDKEAKGFITRHDLQG--LQSDLPltPEQLEAVFESLDQAHTGFLTAREFCLGL 143
Cdd:cd00052     2 DQIFRSLDPDGDGLISGDEARPflGKSGLP--RSVLAQIWDLADTDKDGKLDKEEFAIAM 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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