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Conserved domains on  [gi|1370486534|ref|XP_024309719|]
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methionine aminopeptidase 1 isoform X9 [Homo sapiens]

Protein Classification

M24 family metallopeptidase( domain architecture ID 320)

M24 family metallopeptidase cleaves amido-, imido-, or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP_MetAP super family cl00279
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 3-268 8.16e-172

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


The actual alignment was detected with superfamily member PLN03158:

Pssm-ID: 469704 [Multi-domain]  Cd Length: 396  Bit Score: 480.10  E-value: 8.16e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534   3 ESEQALKGTSQIKllSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTS 82
Cdd:PLN03158  126 EPNSDLQHSVEIK--TPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTS 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  83 VNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNII 162
Cdd:PLN03158  204 VNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVI 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 163 QKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQ 242
Cdd:PLN03158  284 NRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYARNKAVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQ 363

                         250       260
                  ....*....|....*....|....*.
gi 1370486534 243 FEHTLLVTDTGCEILTRRLDSARPHF 268
Cdd:PLN03158  364 FEHTLLVTETGVEVLTARLPSSPDVF 389
 
Name Accession Description Interval E-value
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 3-268 8.16e-172

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 480.10  E-value: 8.16e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534   3 ESEQALKGTSQIKllSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTS 82
Cdd:PLN03158  126 EPNSDLQHSVEIK--TPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTS 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  83 VNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNII 162
Cdd:PLN03158  204 VNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVI 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 163 QKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQ 242
Cdd:PLN03158  284 NRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYARNKAVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQ 363

                         250       260
                  ....*....|....*....|....*.
gi 1370486534 243 FEHTLLVTDTGCEILTRRLDSARPHF 268
Cdd:PLN03158  364 FEHTLLVTETGVEVLTARLPSSPDVF 389
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 22-259 2.45e-154

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 429.61  E-value: 2.45e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  22 IEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGD 101
Cdd:cd01086     1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 102 IVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHG 181
Cdd:cd01086    81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370486534 182 IHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTR 259
Cdd:cd01086   161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
14-260 4.61e-138

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 388.59  E-value: 4.61e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:COG0024     1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV 173
Cdd:COG0024    81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 VRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTG 253
Cdd:COG0024   161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                  ....*..
gi 1370486534 254 CEILTRR 260
Cdd:COG0024   241 PEILTLP 247
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 14-260 9.13e-118

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 337.40  E-value: 9.13e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV 173
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 VRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTG 253
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 1370486534 254 CEILTRR 260
Cdd:TIGR00500 241 PEILTER 247
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 23-251 7.22e-62

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 194.00  E-value: 7.22e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  23 EGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYpsplNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDI 102
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 103 VNVDITL-YRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFS-VVRSYCGH 180
Cdd:pfam00557  77 VLIDVGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370486534 181 GIHKLFHTAPNVPHYAKNkavGVMKSGHVFTIEPMIceggwqdetwpdgwtaVTRDGKRSAQFEHTLLVTD 251
Cdd:pfam00557 157 GIGLEVHEGPYISRGGDD---RVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 3-268 8.16e-172

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 480.10  E-value: 8.16e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534   3 ESEQALKGTSQIKllSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTS 82
Cdd:PLN03158  126 EPNSDLQHSVEIK--TPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTS 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  83 VNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNII 162
Cdd:PLN03158  204 VNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVI 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 163 QKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQ 242
Cdd:PLN03158  284 NRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYARNKAVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQ 363

                         250       260
                  ....*....|....*....|....*.
gi 1370486534 243 FEHTLLVTDTGCEILTRRLDSARPHF 268
Cdd:PLN03158  364 FEHTLLVTETGVEVLTARLPSSPDVF 389
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 22-259 2.45e-154

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 429.61  E-value: 2.45e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  22 IEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGD 101
Cdd:cd01086     1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 102 IVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHG 181
Cdd:cd01086    81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370486534 182 IHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTR 259
Cdd:cd01086   161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
14-260 4.61e-138

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 388.59  E-value: 4.61e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:COG0024     1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV 173
Cdd:COG0024    81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 VRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTG 253
Cdd:COG0024   161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240


                  ....*..
gi 1370486534 254 CEILTRR 260
Cdd:COG0024   241 PEILTLP 247
PRK05716 PRK05716
methionine aminopeptidase; Validated
 14-260 8.92e-138

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 387.95  E-value: 8.92e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:PRK05716    3 ITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIPS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV 173
Cdd:PRK05716   83 DKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFSV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 VRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTG 253
Cdd:PRK05716  163 VREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTEDG 242


                  ....*..
gi 1370486534 254 CEILTRR 260
Cdd:PRK05716  243 PEILTLR 249
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 14-260 9.13e-118

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 337.40  E-value: 9.13e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV 173
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 VRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTG 253
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*..
gi 1370486534 254 CEILTRR 260
Cdd:TIGR00500 241 PEILTER 247
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 14-260 4.58e-108

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 312.93  E-value: 4.58e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:PRK12896    8 MEIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV 173
Cdd:PRK12896   88 PRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSV 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 VRSYCGHGIHKLFHTAPNVPHYAKNKAVGV-MKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDT 252
Cdd:PRK12896  168 VRDLTGHGVGRSLHEEPSVILTYTDPLPNRlLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVVTRD 247


                  ....*...
gi 1370486534 253 GCEILTRR 260
Cdd:PRK12896  248 GPEILTDR 255
PRK12318 PRK12318
methionyl aminopeptidase;
14-258 6.09e-81

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 245.50  E-value: 6.09e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYN--FPKSCCTSVNEVICHGI 91
Cdd:PRK12318   41 IIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  92 PDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGF 171
Cdd:PRK12318  121 PNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGF 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 172 SVVRSYCGHGIHKLFHTAPNVPHYaKNKAVGVMKSGHVFTIEPMICEG---GWQDETwpDGWTAVTRDGKRSAQFEHTLL 248
Cdd:PRK12318  201 SVVDQFVGHGVGIKFHENPYVPHH-RNSSKIPLAPGMIFTIEPMINVGkkeGVIDPI--NHWEARTCDNQPSAQWEHTIL 277

                         250
                  ....*....|
gi 1370486534 249 VTDTGCEILT 258
Cdd:PRK12318  278 ITETGYEILT 287
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 23-251 7.22e-62

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 194.00  E-value: 7.22e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  23 EGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYpsplNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDI 102
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 103 VNVDITL-YRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFS-VVRSYCGH 180
Cdd:pfam00557  77 VLIDVGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370486534 181 GIHKLFHTAPNVPHYAKNkavGVMKSGHVFTIEPMIceggwqdetwpdgwtaVTRDGKRSAQFEHTLLVTD 251
Cdd:pfam00557 157 GIGLEVHEGPYISRGGDD---RVLEPGMVFTIEPGI----------------YFIPGWGGVRIEDTVLVTE 208
PRK12897 PRK12897
type I methionyl aminopeptidase;
8-259 1.61e-50

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 166.36  E-value: 1.61e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534   8 LKGTSQIKLLSsediEGMRLVCRLAREVldvaAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVI 87
Cdd:PRK12897    4 IKTKNEIDLMH----ESGKLLASCHREI----AKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEM 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  88 CHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQ 167
Cdd:PRK12897   76 CHAFPADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 168 ANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTL 247
Cdd:PRK12897  156 NEGFSVARDFTGHGIGKEIHEEPAIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTI 235

                         250
                  ....*....|..
gi 1370486534 248 LVTDTGCEILTR 259
Cdd:PRK12897  236 AITKDGPIILTK 247
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 22-254 1.61e-43

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 146.83  E-value: 1.61e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  22 IEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPlnyynfpkSCCTSVNEV--ICHGIPDRRPLQE 99
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPAG--------PTIVGSGARtaLPHYRPDDRRLQE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 100 GDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVR-SYC 178
Cdd:cd01066    73 GDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFgHRT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370486534 179 GHGIHKLFHTAPNVPHYAKnkavGVMKSGHVFTIEPMICEGGWqdetwpdgwtavtrdgkRSAQFEHTLLVTDTGC 254
Cdd:cd01066   153 GHGIGLEIHEPPVLKAGDD----TVLEPGMVFAVEPGLYLPGG-----------------GGVRIEDTVLVTEDGP 207
PRK07281 PRK07281
methionyl aminopeptidase;
14-258 4.41e-40

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 140.37  E-value: 4.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKLLSSEDIEGMRlvcRLAREVLDVAAG---MIKPGVTTEEIDHAVHLACIARNCYPSPL----NYYNFPKSCCTSVNEV 86
Cdd:PRK07281    2 ITLKSAREIEAMD---RAGDFLASIHIGlrdLIKPGVDMWEVEEYVRRRCKEENVLPLQIgvdgAMMDYPYATCCGLNDE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  87 ICHGIPDRRPLQEGDIVNVDITL------------------------YRNGYHGDLNET---FFVGEVDDGARKLVQTTY 139
Cdd:PRK07281   79 VAHAFPRHYILKEGDLLKVDMVLsepldksivdvsklnfdnveqmkkYTESYRGGLADScwaYAVGTPSDEVKNLMDVTK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 140 ECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEG 219
Cdd:PRK07281  159 EAMYRGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLREGMVLTIEPMINTG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1370486534 220 GWQ-DETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILT 258
Cdd:PRK07281  239 TWEiDTDMKTGWAHKTLDGGLSCQYEHQFVITKDGPVILT 278
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
14-259 3.78e-38

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 135.72  E-value: 3.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  14 IKllSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCypsplNYYNFPKSCCTSVNEVICHGIPD 93
Cdd:COG0006    73 IK--SPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGA-----EGPSFDTIVASGENAAIPHYTPT 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  94 RRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFsv 173
Cdd:COG0006   146 DRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGY-- 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 174 vRSY----CGHGIHKLFHTAPNVphYAKNKavGVMKSGHVFTIEPMIceggwqdetWPDGWTAVtrdgkRSaqfEHTLLV 249
Cdd:COG0006   224 -GEYfphgTGHGVGLDVHEGPQI--SPGND--RPLEPGMVFTIEPGI---------YIPGIGGV-----RI---EDTVLV 281

                         250
                  ....*....|
gi 1370486534 250 TDTGCEILTR 259
Cdd:COG0006   282 TEDGAEVLTR 291
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 22-259 1.36e-30

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 115.43  E-value: 1.36e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  22 IEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSplnyynFPKSCctSVNEVICHGIP---DRRPLQ 98
Cdd:cd01088     1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPA------FPVNL--SINECAAHYTPnagDDTVLK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  99 EGDIVNVDITLYRNGYHGDlneTFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYC 178
Cdd:cd01088    73 EGDVVKLDFGAHVDGYIAD---SAFTVDFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 179 GHGIHK-LFHTAPNVPHYaKNKAVGVMKSGHVFTIEP-------MICEGG------------------------------ 220
Cdd:cd01088   150 GHSIERyRLHAGKSIPNV-KGGEGTRLEEGDVYAIEPfattgkgYVHDGPecsiymlnrdkplrlprarklldviyenfg 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370486534 221 -------WQDETWPDGW-----------------TAVTRDGKRSAQFEHTLLVTDTGCEILTR 259
Cdd:cd01088   229 tlpfarrWLDRLGETKLlmalknlckagivypypVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 22-216 4.54e-28

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 106.82  E-value: 4.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  22 IEGMRLVCRLAREVLDVAAGMIKPGVTteEIDHAVHLACIARN---CYPSplnyynFPKSCCTSVNEVICHGIPDRRPLQ 98
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMT--EREVAAELEYFMRKlgaEGPS------FDTIVASGPNSALPHGVPSDRKIE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  99 EGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELG----NIIQKHAQANGFsvV 174
Cdd:cd01092    73 EGDLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDkaarDVIEEAGYGEYF--I 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1370486534 175 RSyCGHGIHKLFHTAPNVPHYAKnkavGVMKSGHVFTIEPMI 216
Cdd:cd01092   151 HR-TGHGVGLEVHEAPYISPGSD----DVLEEGMVFTIEPGI 187
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 22-259 3.89e-10

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 58.74  E-value: 3.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  22 IEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSplnyYNFPksCCTSVNEVICHGIPDRRPLQEGD 101
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLA----YSYI--VAAGSNAAILHYVHNDQPLKDGD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 102 IVNVDITLYRNGYHGDLNETFFV-GEVDDGARKLVQTTYECLMQAIDAVKPGVRYREL----GNIIQKH----------- 165
Cdd:cd01087    75 LVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhllaHRVLAEGlkelgilkgdv 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 166 AQANGFSVVRSYCGHGI-HKLFHTAPNVPHYAK-NKAVGVMKSGHVFTIEP---MICEGGWQDETWPDGwtavtrdGKRs 240
Cdd:cd01087   155 DEIVESGAYAKFFPHGLgHYLGLDVHDVGGYLRyLRRARPLEPGMVITIEPgiyFIPDLLDVPEYFRGG-------GIR- 226

                         250
                  ....*....|....*....
gi 1370486534 241 aqFEHTLLVTDTGCEILTR 259
Cdd:cd01087   227 --IEDDVLVTEDGPENLTR 243
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 80-258 7.51e-08

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 51.95  E-value: 7.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  80 CTSVNEVICHGIP----DRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDD-----GARKLVQTTYECLMQAIDAVK 150
Cdd:cd01089    62 CISVNNCVCHFSPlksdATYTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAEtpvtgKKADVIAAAHYALEAALRLLR 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 151 PGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNvphyaKNKAVGVMKSGHVFTIEPMIceggwqdetwpdgw 230
Cdd:cd01089   142 PGNQNSDITEAIQKVIVDYGCTPVEGVLSHQLKRVVSSGEG-----KAKLVECVKHGLLFPYPVLY-------------- 202

                         170       180
                  ....*....|....*....|....*...
gi 1370486534 231 tavTRDGKRSAQFEHTLLVTDTGCEILT 258
Cdd:cd01089   203 ---EKEGEVVAQFKLTVLLTPNGVTVLT 227
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 17-213 8.35e-08

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 52.79  E-value: 8.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  17 LSSEDIEGMRLVCRLAREVLDVAAGMIKPGVT----TEEIDHAVHLACIARNcypspLNY-YNFPKSCctSVNEVICHGI 91
Cdd:PTZ00053  153 LSEEQYQDLRRAAEVHRQVRRYAQSVIKPGVKlidiCERIESKSRELIEADG-----LKCgWAFPTGC--SLNHCAAHYT 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  92 P---DRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDgarKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQA 168
Cdd:PTZ00053  226 PntgDKTVLTYDDVCKLDFGTHVNGRIIDCAFTVAFNPKYD---PLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIES 302

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370486534 169 NGFSV---------VRSYCGHGIHK-LFHTAPNVPHYAKNKAVgVMKSGHVFTIE 213
Cdd:PTZ00053  303 YEVEIkgktypiksIRNLNGHSIGPyIIHGGKSVPIVKGGENT-RMEEGELFAIE 356
PRK09795 PRK09795
aminopeptidase; Provisional
 1-257 8.79e-07

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 49.55  E-value: 8.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534   1 MSESEQALKgtsQIKllSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIdhAVHLACIARNcypSPLNYYNFPKSCC 80
Cdd:PRK09795  117 VSATPDVLR---QIK--TPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREI--AAELEWFMRQ---QGAEKASFDTIVA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  81 TSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARK-----LVQTTYECLMQAIDAVKPGVRY 155
Cdd:PRK09795  187 SGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIVLQAQLAAISAIRPGVRC 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 156 RELGNIIQKHAQANGFSVVRSY-CGHGIHKLFHTAPNVphyaKNKAVGVMKSGHVFTIEPMICEGGwqdetwpdgwtavt 234
Cdd:PRK09795  267 QQVDDAARRVITEAGYGDYFGHnTGHAIGIEVHEDPRF----SPRDTTTLQPGMLLTVEPGIYLPG-------------- 328

                         250       260
                  ....*....|....*....|...
gi 1370486534 235 RDGKRsaqFEHTLLVTDTGCEIL 257
Cdd:PRK09795  329 QGGVR---IEDVVLVTPQGAEVL 348
PRK14576 PRK14576
putative endopeptidase; Provisional
 12-268 1.71e-06

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 48.47  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  12 SQIKLLSSE-DIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIArncYPSPlnyyNFPKSCCTSVNEVICHG 90
Cdd:PRK14576  172 NEIRMIKSPwEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMS---FPET----NFSRFNLISVGDNFSPK 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  91 I-PDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQAN 169
Cdd:PRK14576  245 IiADTTPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTS 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 170 GFS-VVRSYCGHGiHKLFHTAPNVPhYAKNKAVGVMKSGHVFTIEpmiceggwqdetwpdgwTAVTRDGKRSAQFEHTLL 248
Cdd:PRK14576  325 GLPhYNRGHLGHG-DGVFLGLEEVP-FVSTQATETFCPGMVLSLE-----------------TPYYGIGVGSIMLEDMIL 385

                         250       260
                  ....*....|....*....|
gi 1370486534 249 VTDTGCEILTRRLDSARPHF 268
Cdd:PRK14576  386 ITDSGFEFLSKLDRDLRRYF 405
PRK15173 PRK15173
peptidase; Provisional
 18-213 1.40e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 45.48  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  18 SSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNcypsplnYYNFPKSCCTSVNEVICHG-IPDRRP 96
Cdd:PRK15173   97 SPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKS-------ETHFSRFHLISVGADFSPKlIPSNTK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  97 LQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGF-SVVR 175
Cdd:PRK15173  170 ACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGLpNYNR 249

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370486534 176 SYCGHGiHKLFHTAPNVPhYAKNKAVGVMKSGHVFTIE 213
Cdd:PRK15173  250 GHLGHG-NGVFLGLEESP-FVSTHATESFTSGMVLSLE 285
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 95-216 2.16e-05

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 44.45  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  95 RPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVR----YRELGNIIQKHaqanG 170
Cdd:cd01090    75 RKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARckdiAAELNEMYREH----D 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370486534 171 FSVVRSYcGHGihklfHTAPNVPHYAKNKA--------VGVMKSGHVFTIEPMI 216
Cdd:cd01090   151 LLRYRTF-GYG-----HSFGVLSHYYGREAglelrediDTVLEPGMVVSMEPMI 198
PRK14575 PRK14575
putative peptidase; Provisional
 18-213 2.18e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 45.08  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  18 SSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNcypsplnYYNFPKSCCTSVNEVICHG-IPDRRP 96
Cdd:PRK14575  180 SPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKS-------ETHFSRFHLISVGADFSPKlIPSNTK 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  97 LQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGF-SVVR 175
Cdd:PRK14575  253 ACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGLpNYNR 332

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370486534 176 SYCGHGiHKLFHTAPNVPhYAKNKAVGVMKSGHVFTIE 213
Cdd:PRK14575  333 GHLGHG-NGVFLGLEESP-FVSTHATESFTSGMVLSLE 368
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 75-180 2.28e-05

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 45.26  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  75 FPKscCTSVNEVICHGIP----DRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDG-----ARKLVQTTYECLMQA 145
Cdd:TIGR00495  78 FPT--CISVNNCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEpvtgrKADVIAAAHLAAEAA 155

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1370486534 146 IDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGH 180
Cdd:TIGR00495 156 LRLVKPGNTNTQVTEAINKVAHSYGCTPVEGMLSH 190
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 18-258 3.13e-04

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 41.63  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  18 SSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACI---ARncYPSplnyYNfpksccTSV----NEVICHG 90
Cdd:PRK10879  175 SPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNrhgAR--YPS----YN------TIVgsgeNGCILHY 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534  91 IPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFV-GEVDDGARKLVQTTYECLMQAIDAVKPGVRYREL----------- 158
Cdd:PRK10879  243 TENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVtgevvrimvsg 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486534 159 --------GNIIQKHA-QANgfsvvRSYCGHGI-HKLFHTAPNVPHYAKNKAvGVMKSGHVFTIEPMICEGgwQDETWPD 228
Cdd:PRK10879  323 lvklgilkGDVDQLIAeNAH-----RPFFMHGLsHWLGLDVHDVGVYGQDRS-RILEPGMVLTVEPGLYIA--PDADVPE 394

                         250       260       270
                  ....*....|....*....|....*....|
gi 1370486534 229 GWTAVtrdGKRsaqFEHTLLVTDTGCEILT 258
Cdd:PRK10879  395 QYRGI---GIR---IEDDIVITETGNENLT 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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