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Conserved domains on  [gi|1370484065|ref|XP_024309282|]
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importin subunit alpha-5 isoform X1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-516 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 582.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065  33 LQLRKQKREEQLFKRRNVATAEEETEEEVMSdggfHEAQISNMemapggviTSDMIEMIFSKSPEQQLSATQKFRKLLSK 112
Cdd:COG5064    34 VELRKQKREELLNKRRNLADVSEEAESSFIP----MEQQFYSE--------LPQLTQQLFSDDIEQQLQAVYKFRKLLSK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 113 EPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWA 192
Cdd:COG5064   102 ETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 193 LGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL 271
Cdd:COG5064   181 LGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 272 ADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPK 351
Cdd:COG5064   261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 352 ESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGS--AEQIKYLVELGCIKPLC 429
Cdd:COG5064   341 ENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLC 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 430 DLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE 509
Cdd:COG5064   421 DLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDA 500


                  ....*..
gi 1370484065 510 DSSIAPQ 516
Cdd:COG5064   501 VDELAPE 507
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-516 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 582.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065  33 LQLRKQKREEQLFKRRNVATAEEETEEEVMSdggfHEAQISNMemapggviTSDMIEMIFSKSPEQQLSATQKFRKLLSK 112
Cdd:COG5064    34 VELRKQKREELLNKRRNLADVSEEAESSFIP----MEQQFYSE--------LPQLTQQLFSDDIEQQLQAVYKFRKLLSK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 113 EPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWA 192
Cdd:COG5064   102 ETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 193 LGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL 271
Cdd:COG5064   181 LGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 272 ADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPK 351
Cdd:COG5064   261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 352 ESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGS--AEQIKYLVELGCIKPLC 429
Cdd:COG5064   341 ENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLC 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 430 DLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE 509
Cdd:COG5064   421 DLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDA 500


                  ....*..
gi 1370484065 510 DSSIAPQ 516
Cdd:COG5064   501 VDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 471-516 7.61e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 79.94  E-value: 7.61e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370484065 471 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 516
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 158-197 1.02e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.97  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1370484065  158 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 197
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-516 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 582.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065  33 LQLRKQKREEQLFKRRNVATAEEETEEEVMSdggfHEAQISNMemapggviTSDMIEMIFSKSPEQQLSATQKFRKLLSK 112
Cdd:COG5064    34 VELRKQKREELLNKRRNLADVSEEAESSFIP----MEQQFYSE--------LPQLTQQLFSDDIEQQLQAVYKFRKLLSK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 113 EPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWA 192
Cdd:COG5064   102 ETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 193 LGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL 271
Cdd:COG5064   181 LGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 272 ADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPK 351
Cdd:COG5064   261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 352 ESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGS--AEQIKYLVELGCIKPLC 429
Cdd:COG5064   341 ENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLC 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 430 DLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE 509
Cdd:COG5064   421 DLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDA 500


                  ....*..
gi 1370484065 510 DSSIAPQ 516
Cdd:COG5064   501 VDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 471-516 7.61e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 79.94  E-value: 7.61e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370484065 471 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 516
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-104 8.38e-19

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 80.66  E-value: 8.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065  10 RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVataeeeteeevmsdgGFHEAQISNMEMaPGGVITSDMIE 89
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNV---------------GAPSSSSSSAES-QLLESLPEMVQ 64

                          90
                  ....*....|....*
gi 1370484065  90 MIFSKSPEQQLSATQ 104
Cdd:pfam01749  65 GVNSDDPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 158-197 8.57e-12

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.78  E-value: 8.57e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1370484065 158 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 197
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 158-197 1.02e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.97  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1370484065  158 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 197
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 369-409 5.07e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.99  E-value: 5.07e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370484065 369 NRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATS 409
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
168-323 5.58e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.94  E-value: 5.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 168 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTmcrdyvldcniLPPLLQLFSKQNRLTmTRNAVWALSNLcrgKSPpp 247
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA-----------VPALLEALKDPDPEV-RAAAAEALGRI---GDP-- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370484065 248 efAKVSPCLNVLSWllfvSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 323
Cdd:COG1413    78 --EAVPALIAALKD----EDPEVRRAAAEALGRLGD------PAAVPA-----LLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 200-241 8.69e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 8.69e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370484065 200 STMCRDYVLDCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 241
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPD-EEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 285-325 2.02e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 2.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370484065 285 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT 325
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 412-452 4.21e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.29  E-value: 4.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370484065 412 SAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 452
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 285-324 8.51e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 8.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1370484065  285 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 324
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 143-196 6.41e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 43.51  E-value: 6.41e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370484065 143 LQFESAWVLTNIASGNSLQTRIVIQAgAVPIFIELLSSEFEDVQEQAVWALGNI 196
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 128-237 9.85e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 9.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 128 VARFVEFLKRKENCTLQFESAWVLTNIASgnslqtriviqAGAVPIFIELLSSEFEDVQEQAVWALGNIaGDSTMcrdyv 207
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 1370484065 208 ldcniLPPLLQLFSKQNRLTMTRNAVWALS 237
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 369-409 1.29e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1370484065  369 NRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATS 409
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 412-450 1.75e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.75e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370484065  412 SAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENI 450
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 200-241 1.85e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 1.85e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1370484065  200 STMCRDYVLDCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 241
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
230-404 2.53e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.15  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 230 RNAVWALSNLcrgkspppefaKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHND 309
Cdd:COG1413     3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD------PRAVPA-----LLEALKDPD 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 310 YKVVSPALRAVGNIvtGDDIQTQVILNcsalqsllhLLSSPKESIKKEACWTISNITagnraqiqtviDANIFPALISIL 389
Cdd:COG1413    61 PEVRAAAAEALGRI--GDPEAVPALIA---------ALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                         170
                  ....*....|....*
gi 1370484065 390 QTAEFRTRKEAAWAI 404
Cdd:COG1413   119 KDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
185-323 3.10e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.15  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484065 185 VQEQAVWALGNIAGDSTmcrdyvldcniLPPLLQLFSKQNRLTMtRNAVWALSNLCRGKSPPPefakvspclnvLSWLLF 264
Cdd:COG1413     1 VRRAAARALGRLGDPAA-----------VPALIAALADEDPDVR-AAAARALGRLGDPRAVPA-----------LLEALK 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370484065 265 VSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 323
Cdd:COG1413    58 DPDPEVRAAAAEALGRIGD------PEAVPA-----LIAALKDEDPEVRRAAAEALGRL 105
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 244-283 1.26e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1370484065 244 SPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSD 283
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-156 1.80e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 1.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1370484065 114 PNPPIDEVIStPGVVARFVEFLKrKENCTLQFESAWVLTNIAS 156
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 353-406 4.62e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 4.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370484065 353 SIKKEACWTISNITAGNRAQIQTVIDaNIFPALISILQTAEFRTRKEAAWAITN 406
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGR 54
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 185-239 5.41e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 5.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370484065 185 VQEQAVWALGNIAGDSTM-CRDYVLDcnILPPLLQLfSKQNRLTMTRNAVWALSNL 239
Cdd:pfam13513   3 VREAAALALGSLAEGGPDlLAPAVPE--LLPALLPL-LNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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