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Conserved domains on  [gi|1370476713|ref|XP_024308464|]
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flagellum-associated coiled-coil domain-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
113-416 6.91e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 6.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSsemdlrcaEMKQNFENKNRELKEAhEAELSELENNY 192
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE--------ELEEELEQLRKELEEL-SRQISALRKDL 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  193 KAALKAEKLAAQEkLEEMGKEYKYLKNMFRTYQDSIyDEMEEKWSKQKAKWKK-DEKFERENILLQQKKKMTKKFEMESG 271
Cdd:TIGR02168  736 ARLEAEVEQLEER-IAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEElEAQIEQLKEELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  272 EEDKKinescsavFENFIQEKEELLKQHQSDTLQLEELRKTKEVpwRRDQINRHWHDVLQQLLLMQVMQEELHAQALILE 351
Cdd:TIGR02168  814 LLNEE--------AANLRERLESLERRIAATERRLEDLEEQIEE--LSEDIESLAAEIEELEELIEELESELEALLNERA 883
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370476713  352 SLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIhLKQKIISKNEEICE 416
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSE 947
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
113-416 6.91e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 6.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSsemdlrcaEMKQNFENKNRELKEAhEAELSELENNY 192
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE--------ELEEELEQLRKELEEL-SRQISALRKDL 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  193 KAALKAEKLAAQEkLEEMGKEYKYLKNMFRTYQDSIyDEMEEKWSKQKAKWKK-DEKFERENILLQQKKKMTKKFEMESG 271
Cdd:TIGR02168  736 ARLEAEVEQLEER-IAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEElEAQIEQLKEELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  272 EEDKKinescsavFENFIQEKEELLKQHQSDTLQLEELRKTKEVpwRRDQINRHWHDVLQQLLLMQVMQEELHAQALILE 351
Cdd:TIGR02168  814 LLNEE--------AANLRERLESLERRIAATERRLEDLEEQIEE--LSEDIESLAAEIEELEELIEELESELEALLNERA 883
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370476713  352 SLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIhLKQKIISKNEEICE 416
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSE 947
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
113-416 6.91e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 6.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSsemdlrcaEMKQNFENKNRELKEAhEAELSELENNY 192
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE--------ELEEELEQLRKELEEL-SRQISALRKDL 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  193 KAALKAEKLAAQEkLEEMGKEYKYLKNMFRTYQDSIyDEMEEKWSKQKAKWKK-DEKFERENILLQQKKKMTKKFEMESG 271
Cdd:TIGR02168  736 ARLEAEVEQLEER-IAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEElEAQIEQLKEELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  272 EEDKKinescsavFENFIQEKEELLKQHQSDTLQLEELRKTKEVpwRRDQINRHWHDVLQQLLLMQVMQEELHAQALILE 351
Cdd:TIGR02168  814 LLNEE--------AANLRERLESLERRIAATERRLEDLEEQIEE--LSEDIESLAAEIEELEELIEELESELEALLNERA 883
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370476713  352 SLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIhLKQKIISKNEEICE 416
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSE 947
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
127-343 7.47e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 7.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  127 ISDLEEQISELTAIIEQMNRDHQSAQKLLS------SEMDLRCAEMKQNFENKNRELKEAhEAELSELENNyKAALKAEK 200
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYalaneiSRLEQQKQILRERLANLERQLEEL-EAQLEELESK-LDELAEEL 339
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  201 LAAQEKLEEMGKEYKYLKNMFRTYQDsIYDEMEEKWSKQKAKW--KKDEKFEREN-------------ILLQQKKKMTKK 265
Cdd:TIGR02168  340 AELEEKLEELKEELESLEAELEELEA-ELEELESRLEELEEQLetLRSKVAQLELqiaslnneierleARLERLEDRRER 418
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476713  266 FEMESGEEDKKINES----CSAVFENFIQEKEELLKQHQSDTLQLEELRKT-KEVPWRRDQINRHWHDVLQQLLLMQVMQ 340
Cdd:TIGR02168  419 LQQEIEELLKKLEEAelkeLQAELEELEEELEELQEELERLEEALEELREElEEAEQALDAAERELAQLQARLDSLERLQ 498

                   ...
gi 1370476713  341 EEL 343
Cdd:TIGR02168  499 ENL 501
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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