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Conserved domains on  [gi|1370475440|ref|XP_024307354|]
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zinc finger protein 823 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-514 9.03e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 9.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440  77 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 153
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 154 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 231
Cdd:COG5048    86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 232 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 308
Cdd:COG5048   166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 309 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 379
Cdd:COG5048   236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 380 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 444
Cdd:COG5048   316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370475440 445 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 514
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-534 1.68e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475440 510 LLRHERIHTGEKPYECLQCGKAFTR 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-514 9.03e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 9.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440  77 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 153
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 154 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 231
Cdd:COG5048    86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 232 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 308
Cdd:COG5048   166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 309 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 379
Cdd:COG5048   236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 380 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 444
Cdd:COG5048   316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370475440 445 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 514
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-394 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....
gi 1370475440 371 FQRHERTHTGEKPYQCKQCGKAFS 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-534 1.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475440 510 LLRHERIHTGEKPYECLQCGKAFTR 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-514 9.03e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 9.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440  77 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 153
Cdd:COG5048     6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 154 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 231
Cdd:COG5048    86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 232 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 308
Cdd:COG5048   166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 309 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 379
Cdd:COG5048   236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 380 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 444
Cdd:COG5048   316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370475440 445 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 514
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-573 5.46e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 5.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 159 PYKCKLCGKAFVWPSLFHLHERTHTGEKPYEC--KQCSKAFPFYSSYLRHERIHTGEKAYEC-KQCSKAFPDYSTYLRHE 235
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 236 RTHTGEKPYKCTQCGKAFSCYYYTRLHERTHTGEQPYACKQCgkTFYHHTSFRRHMIRHTGDGPHKCKICGKgfdcPSSV 315
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN--NSSSVNTPQSNSLHPPLPANSLSKDPSS----NLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 316 RNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDGPQKCKICGkaFGCPSLFQRHERTHTGEKpyqckqcgkafsl 395
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS------------- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 396 agslrrHEATHTGVKPYKCQCGKAFSDLSSFQNHETTHTG-EKPYECKECGKAFSCFKYLSQHKRT--HTVE--KPYEC- 469
Cdd:COG5048   252 ------DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCp 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 470 -KTCRKAFSHFSNLKVHERIHSGEKPYECKEC-------GKAFSWLTCLLRHERIHTGEKPYECL--QCGKAFTRSRFLR 539
Cdd:COG5048   326 ySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1370475440 540 GHEKTHTGEKLYECK--ECGKALSSLRSLHRHKRTH 573
Cdd:COG5048   406 LHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-525 1.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 242 KPYKCTQCGKAFSCYYYTRLHERTHTGEQPYAC--KQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG--FDCPSSVRN 317
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 318 HETTHTgEKPYECKQCGKVLSHSSSFRSHMITHTGDGPQKCKICGKAFG----------------------CPSLFQRHE 375
Cdd:COG5048   112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 376 RTHTGEKPYQCKQCG----KAFSLAGSLRRHEAThTGVKPYKCQCGKAFSDLSSFQNHETthtgeKPYECKECGKAFSCF 451
Cdd:COG5048   191 NVSTSIPSSSENSPLsssySIPSSSSDQNLENSS-SSLPLTTNSQLSPKSLLSQSPSSLS-----SSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 452 KYLSQHKRTHTVE----------KPYECKTCRKAFSHFSNLKVHER--IHSGE--KPYECKE--CGKAFSWLTCLLRHER 515
Cdd:COG5048   265 LPTASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330
                  ....*....|
gi 1370475440 516 IHTGEKPYEC 525
Cdd:COG5048   345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-404 2.27e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 220 QCSKAFPDYSTYLRHERTHTG-EKPYKCTQCGKAFSCYYYTRLHERT--HTGE--QPYAC--KQCGKTFYHHTSFRRHMI 292
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475440 293 RHTGDGPHKCKICGKGFD-------CPSSVRNHETTHTGEKPYEC--KQCGKVLSHSSSFRSHMITHTGDGP--QKCKIC 361
Cdd:COG5048   345 LHTSISPAKEKLLNSSSKfspllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370475440 362 GKAFGCPSLFQRHERTHTGEKPYQCKQCGKAFSLAGSLRRHEA 404
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-394 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....
gi 1370475440 371 FQRHERTHTGEKPYQCKQCGKAFS 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475440 481 NLKVHERIHSGEKPYECKECGKAFS 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-255 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|...
gi 1370475440 233 RHERTHTGEKPYKCTQCGKAFSC 255
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
510-534 1.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475440 510 LLRHERIHTGEKPYECLQCGKAFTR 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 3.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475440 453 YLSQHKRTHTVEKPYECKTCRKAFSH 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-170 5.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.21e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475440 146 NLRRHMAAHHGDGPYKCKLCGKAFV 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 7.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475440 425 SFQNHETTHTGEKPYECKECGKAFSC 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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