mitochondrial enolase superfamily member 1 isoform X11 [Homo sapiens]
Protein Classification
enolase-like domain-containing protein( domain architecture ID 1750080)
enolase-like domain-containing protein is an enzyme characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| enolase_like super family | cl40480 | Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ... |
19-342 | 0e+00 | ||||||
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase. The actual alignment was detected with superfamily member cd03324: Pssm-ID: 477366 [Multi-domain] Cd Length: 415 Bit Score: 681.38 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||
| rTSbeta_L-fuconate_dehydratase | cd03324 | Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also ... |
19-342 | 0e+00 | ||||||
Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism. A member of this family, from Xanthomonas, has been characterized to be a L-fuconate dehydratase. rTS beta belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239440 [Multi-domain] Cd Length: 415 Bit Score: 681.38 E-value: 0e+00
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| RspA | COG4948 | L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ... |
14-349 | 6.02e-66 | ||||||
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway Pssm-ID: 443975 [Multi-domain] Cd Length: 359 Bit Score: 212.76 E-value: 6.02e-66
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| MR_MLE_C | pfam13378 | Enolase C-terminal domain-like; This domain appears at the C-terminus of many of the proteins ... |
122-345 | 4.56e-60 | ||||||
Enolase C-terminal domain-like; This domain appears at the C-terminus of many of the proteins that carry the MR_MLE_N pfam02746 domain. EC:4.2.1.40. Pssm-ID: 463862 [Multi-domain] Cd Length: 217 Bit Score: 192.78 E-value: 4.56e-60
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| MR_MLE | smart00922 | Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase (MR) ... |
119-217 | 9.35e-26 | ||||||
Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase (MR) and muconate lactonizing enzyme (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures.. This entry represents the C-terminal region of these proteins. Pssm-ID: 214914 [Multi-domain] Cd Length: 97 Bit Score: 99.28 E-value: 9.35e-26
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| PRK15440 | PRK15440 | L-rhamnonate dehydratase; Provisional |
145-282 | 7.48e-12 | ||||||
L-rhamnonate dehydratase; Provisional Pssm-ID: 185337 [Multi-domain] Cd Length: 394 Bit Score: 65.91 E-value: 7.48e-12
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| Name | Accession | Description | Interval | E-value | ||||||
| rTSbeta_L-fuconate_dehydratase | cd03324 | Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also ... |
19-342 | 0e+00 | ||||||
Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to mediate the down-regulation of thymidylate synthase protein by a novel intercellular signaling mechanism. A member of this family, from Xanthomonas, has been characterized to be a L-fuconate dehydratase. rTS beta belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239440 [Multi-domain] Cd Length: 415 Bit Score: 681.38 E-value: 0e+00
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| RspA | COG4948 | L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ... |
14-349 | 6.02e-66 | ||||||
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway Pssm-ID: 443975 [Multi-domain] Cd Length: 359 Bit Score: 212.76 E-value: 6.02e-66
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| MR_MLE_C | pfam13378 | Enolase C-terminal domain-like; This domain appears at the C-terminus of many of the proteins ... |
122-345 | 4.56e-60 | ||||||
Enolase C-terminal domain-like; This domain appears at the C-terminus of many of the proteins that carry the MR_MLE_N pfam02746 domain. EC:4.2.1.40. Pssm-ID: 463862 [Multi-domain] Cd Length: 217 Bit Score: 192.78 E-value: 4.56e-60
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| MR_like | cd03316 | Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup ... |
13-340 | 2.73e-59 | ||||||
Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD). Pssm-ID: 239432 [Multi-domain] Cd Length: 357 Bit Score: 195.52 E-value: 2.73e-59
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| MR_like_2 | cd03327 | Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this ... |
14-342 | 6.28e-34 | ||||||
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown. Pssm-ID: 239443 [Multi-domain] Cd Length: 341 Bit Score: 128.22 E-value: 6.28e-34
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| MR_like_3 | cd03328 | Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this ... |
12-278 | 3.88e-26 | ||||||
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown. Pssm-ID: 239444 [Multi-domain] Cd Length: 352 Bit Score: 107.11 E-value: 3.88e-26
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| MR_MLE | smart00922 | Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase (MR) ... |
119-217 | 9.35e-26 | ||||||
Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase (MR) and muconate lactonizing enzyme (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures.. This entry represents the C-terminal region of these proteins. Pssm-ID: 214914 [Multi-domain] Cd Length: 97 Bit Score: 99.28 E-value: 9.35e-26
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| enolase_like | cd00308 | Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ... |
125-291 | 8.19e-25 | ||||||
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase. Pssm-ID: 238188 [Multi-domain] Cd Length: 229 Bit Score: 100.86 E-value: 8.19e-25
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| MLE_like | cd03315 | Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this ... |
27-291 | 6.04e-16 | ||||||
Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can function as general acid/base catalysts, a Lys-X-Lys motif and another conserved lysine. Despite these conserved residues, the members of the MLE subgroup, like muconate lactonizing enzyme, o-succinylbenzoate synthase (OSBS) and N-acylamino acid racemase (NAAAR), catalyze different reactions. Pssm-ID: 239431 [Multi-domain] Cd Length: 265 Bit Score: 77.00 E-value: 6.04e-16
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| D-galactonate_dehydratase | cd03325 | D-galactonate dehydratase catalyses the dehydration of galactonate to ... |
27-284 | 1.23e-15 | ||||||
D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactonate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239441 [Multi-domain] Cd Length: 352 Bit Score: 76.98 E-value: 1.23e-15
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| mandelate_racemase | cd03321 | Mandelate racemase (MR) catalyzes the Mg2+-dependent 1,1-proton transfer reaction that ... |
128-350 | 5.67e-15 | ||||||
Mandelate racemase (MR) catalyzes the Mg2+-dependent 1,1-proton transfer reaction that interconverts the enantiomers of mandelic acid. MR is the first enzyme in the bacterial pathway that converts mandelic acid to benzoic acid and allows this pathway to utilize either enantiomer of mandelate. MR belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239437 [Multi-domain] Cd Length: 355 Bit Score: 75.21 E-value: 5.67e-15
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| OSBS | cd03320 | o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2, ... |
110-275 | 1.70e-13 | ||||||
o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway. Menaquinone is an essential cofactor for anaerobic growth in eubacteria and some archaea. OSBS belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239436 [Multi-domain] Cd Length: 263 Bit Score: 69.60 E-value: 1.70e-13
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| L-Ala-DL-Glu_epimerase | cd03319 | L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The ... |
32-233 | 6.42e-13 | ||||||
L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239435 [Multi-domain] Cd Length: 316 Bit Score: 68.75 E-value: 6.42e-13
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| MR_like_1 | cd03326 | Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this ... |
32-228 | 9.85e-13 | ||||||
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown. Pssm-ID: 239442 [Multi-domain] Cd Length: 385 Bit Score: 68.57 E-value: 9.85e-13
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| PRK15440 | PRK15440 | L-rhamnonate dehydratase; Provisional |
145-282 | 7.48e-12 | ||||||
L-rhamnonate dehydratase; Provisional Pssm-ID: 185337 [Multi-domain] Cd Length: 394 Bit Score: 65.91 E-value: 7.48e-12
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| PRK14017 | PRK14017 | galactonate dehydratase; Provisional |
32-348 | 7.15e-10 | ||||||
galactonate dehydratase; Provisional Pssm-ID: 184455 [Multi-domain] Cd Length: 382 Bit Score: 59.91 E-value: 7.15e-10
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| MLE | cd03318 | Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis, ... |
30-220 | 5.79e-09 | ||||||
Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived aromatics, catechol and protocatechuate, to citric acid cycle intermediates. Some bacterial species are also capable of dehalogenating chloroaromatic compounds by the action of chloromuconate lactonizing enzymes (Cl-MLEs). MLEs are members of the enolase superfamily characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and that is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239434 [Multi-domain] Cd Length: 365 Bit Score: 56.94 E-value: 5.79e-09
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| NAAAR | cd03317 | N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of ... |
31-348 | 8.46e-07 | ||||||
N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Pssm-ID: 239433 [Multi-domain] Cd Length: 354 Bit Score: 50.31 E-value: 8.46e-07
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| RspA | cd03322 | The starvation sensing protein RspA from E.coli and its homologs are lactonizing enzymes whose ... |
23-358 | 3.29e-06 | ||||||
The starvation sensing protein RspA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subfamily share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and catalytic residues, a partially conserved Lys-X-Lys motif and a conserved histidine-aspartate dyad. Pssm-ID: 239438 [Multi-domain] Cd Length: 361 Bit Score: 48.59 E-value: 3.29e-06
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| PRK02901 | PRK02901 | O-succinylbenzoate synthase; Provisional |
133-201 | 3.35e-06 | ||||||
O-succinylbenzoate synthase; Provisional Pssm-ID: 235084 [Multi-domain] Cd Length: 327 Bit Score: 48.43 E-value: 3.35e-06
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| MR_like_4 | cd03329 | Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this ... |
32-282 | 6.31e-06 | ||||||
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown. Pssm-ID: 239445 [Multi-domain] Cd Length: 368 Bit Score: 47.78 E-value: 6.31e-06
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| PLN02980 | PLN02980 | 2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ... |
125-208 | 1.95e-04 | ||||||
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding Pssm-ID: 215530 [Multi-domain] Cd Length: 1655 Bit Score: 43.69 E-value: 1.95e-04
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| PRK02714 | PRK02714 | o-succinylbenzoate synthase; |
109-205 | 6.33e-03 | ||||||
o-succinylbenzoate synthase; Pssm-ID: 235061 [Multi-domain] Cd Length: 320 Bit Score: 38.07 E-value: 6.33e-03
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| Blast search parameters | ||||
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