View
Concise Results
Standard Results
Full Results
phosphoribosylformylglycinamidine synthase isoform X1 [Homo sapiens]
Protein Classification
phosphoribosylformylglycinamidine synthase ( domain architecture ID 11493078 )
phosphoribosylformylglycinamidine synthase catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
List of domain hits
Name
Accession
Description
Interval
E-value
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
7-1333
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2200.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 7 F YVR PS GHE G AAPGHTRR KLQ G K L PEL Q GV ET E L CY N V N W TAEALPSA EE TKK L MW L F G CP L LLDD vare S W L LP G sndl 86
Cdd:TIGR01735 1 F LRG PS ALS G FRLEKLLQ KLQ T K V PEL T GV YA E F CY F V G W ESALTADE EE KLQ L LL L A G SV L EPPQ ---- S P L GR G ---- 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 87 LLEVGPRL NFST P T S TNIV S VC R AT GL GP VDR V E TT RRY R LS F AHP P S A E V EA I A L A T LHDRMTE QHF PH P I QS F SPE S M 166
Cdd:TIGR01735 73 LLEVGPRL GTIS P W S SKAT S IA R NC GL AK VDR I E RG RRY Y LS G AHP L S E E Q EA Q A A A L LHDRMTE SVL PH E I EA F ELF S V 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 167 PEPLN G - P I NI LG E GRLALEKANQELGLALD SWDL D FY TKRFQELQRNPS T VE AFDL AQ S NSEH S RH WF F KGQLHV DG Q K 245
Cdd:TIGR01735 153 PEPLN L t T I DV LG G GRLALEKANQELGLALD EDEI D YL TKRFQELQRNPS D VE LMMF AQ A NSEH C RH KI F NADWII DG K K 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 246 LVH SLF ES I M ST Q E SSNP N N V LKFC DNSS A I Q G KE V RF LRP ED PTRP SRF Q Q Q QG L R H VVFTA ETHN F PT GVC PF S GA T T 325
Cdd:TIGR01735 233 QDK SLF QM I K ST H E ANPE N T V SAYK DNSS V I E G HK V GR LRP DP PTRP EYR Q H Q ED L V H ILMKV ETHN H PT AIA PF P GA S T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 326 G T GG R IRD VQC TGRGA HVV AG TA G Y C FG NL H IPG YNL PWEDP s FQ Y P GNF A R PL EVA IEA SN GA SDYG N K FG E P V L A G FA 405
Cdd:TIGR01735 313 G A GG E IRD EGA TGRGA KPK AG LT G F C VS NL N IPG LEQ PWEDP - FQ K P ERI A S PL DIM IEA PL GA AAFN N E FG R P N L L G YF 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 406 R SLG L Q -- LP D GQ R R EWI KPIM FS GGIGS ME A D HI S K EAP EPG MEVVKV GGP VYR IG V GGGAASS v Q V Q G D NT S DLDF GA 483
Cdd:TIGR01735 392 R TFE L K as LP G GQ V R GYH KPIM LA GGIGS ID A E HI Q K GEI EPG ALLIVL GGP AML IG L GGGAASS - M V S G T NT A DLDF AS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 484 VQRG D PEME QKMNR VI RA C VEAPKG NPI C S L HD Q GAGG NG N V L K EL SDPA -- GA I I YTSRFQ L G DP T L NA LEIW GA E Y QE 561
Cdd:TIGR01735 471 VQRG N PEME RRCQE VI DR C WQLGEK NPI I S I HD V GAGG LS N A L P EL IHDG gr GA V I DLRAVP L D DP G L SP LEIW CN E S QE 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 562 SNA LL L R SP N RDFL T HVSA RERCP ACF VGT I TGD R R IV LVDD re C PVRRNGQGDAP PTPLPT PVDL E LE WV LGKMP RKEF 641
Cdd:TIGR01735 551 RYV LL V R AE N LEIF T AICE RERCP FAV VGT A TGD G R LT LVDD -- T PVRRNGQGDAP SHFPNN PVDL P LE VL LGKMP KMTR 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 642 F L QRK P PMLQPL AL PPGL SV H Q ALERVLRLPAVASKR Y L TNKV DRSVGGLVA QQ Q C VGP L QTPLADVAV V A L S HEELI G A 721
Cdd:TIGR01735 629 F V QRK A PMLQPL DI PPGL DL H E ALERVLRLPAVASKR F L ITIG DRSVGGLVA RD Q M VGP W QTPLADVAV T A A S FDTYT G E 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 722 A T A L GE Q P V K S LLDPK VA ARLAV A EA L TNL VF ALV T DL R DVK C S G NWM W AA KL PGE G AAL A DA CE A MVAVMA ALG V A VDG 801
Cdd:TIGR01735 709 A M A I GE R P P K A LLDPK AS ARLAV G EA I TNL AA ALV G DL S DVK L S A NWM A AA GH PGE D AAL Y DA VK A VSELCP ALG I A IPV 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 802 GKDSLSM AA R VG ---- T ET V R APGSLVISA Y A VC PD ITA TVTPDLKH PE G RG HLL Y V A L S PG QH RLGG T ALAQ C F S QLG E 877
Cdd:TIGR01735 789 GKDSLSM KT R WQ dnge T KS V T APGSLVISA F A PV PD VRK TVTPDLKH DK G DS HLL L V D L G PG KN RLGG S ALAQ V F G QLG G 868
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 878 HP PDLD L PE N L VRA F SIT QGL LKDR LL CSG HD V SDGGLVT C LLEMAFAG N CGL Q VD VPVPRVDVLS VLF A EE P G L V LE V Q 957
Cdd:TIGR01735 869 DC PDLD D PE R L KAF F AVM QGL VAEG LL LAY HD R SDGGLVT T LLEMAFAG H CGL D VD LDALGDSLFA VLF N EE L G A V IQ V A 948
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 958 E PDLA Q VL KRY R D AGL HC L E LG HTGEA G p H A M V R V SVNGA VV L E E PVG ELR AL WEETSFQL D RL QAE P R C VA EE ER GLR E 1037
Cdd:TIGR01735 949 K PDLA A VL ELL R A AGL TA L I LG IGTPT G - H P M I R I SVNGA TL L S E KRS ELR DI WEETSFQL Q RL RDN P E C AE EE FE GLR D 1027
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1038 R M GP SYC LP P TF PKASVPRE P G --- G PS P R VAILRE E G S NGDREMA D AF HL AGFE V WDV T M Q DL CS G AIG LD T FRG V A FV 1114
Cdd:TIGR01735 1028 R D GP GLK LP L TF DVNEDIAA P F ink G VK P K VAILRE Q G V NGDREMA A AF DR AGFE A WDV H M S DL LA G RVH LD E FRG L A AC 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1115 GGFSY A DVLG SA KGWA AAVT F H PR AGAELRR F R KRPDTFSLGVCNGCQ L L A - LL G W VG G DP N EDA aemgpdsqparpgl L 1193
Cdd:TIGR01735 1108 GGFSY G DVLG AG KGWA KSIL F N PR LRDQFQA F F KRPDTFSLGVCNGCQ M L S n LL E W IP G TE N WPH -------------- F 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1194 L R H N l S G R Y E S R W ASVRVG PG P AL MLRGM E G AV LPV WS AHGEGY V AFSSPELQAQ IE A R GLA P L HWA DDDGNPTE Q YPLN 1273
Cdd:TIGR01735 1174 V R N N - S E R F E A R V ASVRVG ES P SI MLRGM A G SR LPV AV AHGEGY A AFSSPELQAQ AD A S GLA A L RYI DDDGNPTE A YPLN 1252
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1274 PNGSPGG V AGI C SCDGR HLAV MPHPER AV R P WQ WA WRP PPF D TL T ts PWL Q LF I NARNW T 1333
Cdd:TIGR01735 1253 PNGSPGG I AGI T SCDGR VTIM MPHPER VF R A WQ NS WRP EDW D ED T -- PWL R LF R NARNW L 1310
Name
Accession
Description
Interval
E-value
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
7-1333
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2200.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 7 F YVR PS GHE G AAPGHTRR KLQ G K L PEL Q GV ET E L CY N V N W TAEALPSA EE TKK L MW L F G CP L LLDD vare S W L LP G sndl 86
Cdd:TIGR01735 1 F LRG PS ALS G FRLEKLLQ KLQ T K V PEL T GV YA E F CY F V G W ESALTADE EE KLQ L LL L A G SV L EPPQ ---- S P L GR G ---- 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 87 LLEVGPRL NFST P T S TNIV S VC R AT GL GP VDR V E TT RRY R LS F AHP P S A E V EA I A L A T LHDRMTE QHF PH P I QS F SPE S M 166
Cdd:TIGR01735 73 LLEVGPRL GTIS P W S SKAT S IA R NC GL AK VDR I E RG RRY Y LS G AHP L S E E Q EA Q A A A L LHDRMTE SVL PH E I EA F ELF S V 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 167 PEPLN G - P I NI LG E GRLALEKANQELGLALD SWDL D FY TKRFQELQRNPS T VE AFDL AQ S NSEH S RH WF F KGQLHV DG Q K 245
Cdd:TIGR01735 153 PEPLN L t T I DV LG G GRLALEKANQELGLALD EDEI D YL TKRFQELQRNPS D VE LMMF AQ A NSEH C RH KI F NADWII DG K K 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 246 LVH SLF ES I M ST Q E SSNP N N V LKFC DNSS A I Q G KE V RF LRP ED PTRP SRF Q Q Q QG L R H VVFTA ETHN F PT GVC PF S GA T T 325
Cdd:TIGR01735 233 QDK SLF QM I K ST H E ANPE N T V SAYK DNSS V I E G HK V GR LRP DP PTRP EYR Q H Q ED L V H ILMKV ETHN H PT AIA PF P GA S T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 326 G T GG R IRD VQC TGRGA HVV AG TA G Y C FG NL H IPG YNL PWEDP s FQ Y P GNF A R PL EVA IEA SN GA SDYG N K FG E P V L A G FA 405
Cdd:TIGR01735 313 G A GG E IRD EGA TGRGA KPK AG LT G F C VS NL N IPG LEQ PWEDP - FQ K P ERI A S PL DIM IEA PL GA AAFN N E FG R P N L L G YF 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 406 R SLG L Q -- LP D GQ R R EWI KPIM FS GGIGS ME A D HI S K EAP EPG MEVVKV GGP VYR IG V GGGAASS v Q V Q G D NT S DLDF GA 483
Cdd:TIGR01735 392 R TFE L K as LP G GQ V R GYH KPIM LA GGIGS ID A E HI Q K GEI EPG ALLIVL GGP AML IG L GGGAASS - M V S G T NT A DLDF AS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 484 VQRG D PEME QKMNR VI RA C VEAPKG NPI C S L HD Q GAGG NG N V L K EL SDPA -- GA I I YTSRFQ L G DP T L NA LEIW GA E Y QE 561
Cdd:TIGR01735 471 VQRG N PEME RRCQE VI DR C WQLGEK NPI I S I HD V GAGG LS N A L P EL IHDG gr GA V I DLRAVP L D DP G L SP LEIW CN E S QE 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 562 SNA LL L R SP N RDFL T HVSA RERCP ACF VGT I TGD R R IV LVDD re C PVRRNGQGDAP PTPLPT PVDL E LE WV LGKMP RKEF 641
Cdd:TIGR01735 551 RYV LL V R AE N LEIF T AICE RERCP FAV VGT A TGD G R LT LVDD -- T PVRRNGQGDAP SHFPNN PVDL P LE VL LGKMP KMTR 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 642 F L QRK P PMLQPL AL PPGL SV H Q ALERVLRLPAVASKR Y L TNKV DRSVGGLVA QQ Q C VGP L QTPLADVAV V A L S HEELI G A 721
Cdd:TIGR01735 629 F V QRK A PMLQPL DI PPGL DL H E ALERVLRLPAVASKR F L ITIG DRSVGGLVA RD Q M VGP W QTPLADVAV T A A S FDTYT G E 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 722 A T A L GE Q P V K S LLDPK VA ARLAV A EA L TNL VF ALV T DL R DVK C S G NWM W AA KL PGE G AAL A DA CE A MVAVMA ALG V A VDG 801
Cdd:TIGR01735 709 A M A I GE R P P K A LLDPK AS ARLAV G EA I TNL AA ALV G DL S DVK L S A NWM A AA GH PGE D AAL Y DA VK A VSELCP ALG I A IPV 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 802 GKDSLSM AA R VG ---- T ET V R APGSLVISA Y A VC PD ITA TVTPDLKH PE G RG HLL Y V A L S PG QH RLGG T ALAQ C F S QLG E 877
Cdd:TIGR01735 789 GKDSLSM KT R WQ dnge T KS V T APGSLVISA F A PV PD VRK TVTPDLKH DK G DS HLL L V D L G PG KN RLGG S ALAQ V F G QLG G 868
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 878 HP PDLD L PE N L VRA F SIT QGL LKDR LL CSG HD V SDGGLVT C LLEMAFAG N CGL Q VD VPVPRVDVLS VLF A EE P G L V LE V Q 957
Cdd:TIGR01735 869 DC PDLD D PE R L KAF F AVM QGL VAEG LL LAY HD R SDGGLVT T LLEMAFAG H CGL D VD LDALGDSLFA VLF N EE L G A V IQ V A 948
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 958 E PDLA Q VL KRY R D AGL HC L E LG HTGEA G p H A M V R V SVNGA VV L E E PVG ELR AL WEETSFQL D RL QAE P R C VA EE ER GLR E 1037
Cdd:TIGR01735 949 K PDLA A VL ELL R A AGL TA L I LG IGTPT G - H P M I R I SVNGA TL L S E KRS ELR DI WEETSFQL Q RL RDN P E C AE EE FE GLR D 1027
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1038 R M GP SYC LP P TF PKASVPRE P G --- G PS P R VAILRE E G S NGDREMA D AF HL AGFE V WDV T M Q DL CS G AIG LD T FRG V A FV 1114
Cdd:TIGR01735 1028 R D GP GLK LP L TF DVNEDIAA P F ink G VK P K VAILRE Q G V NGDREMA A AF DR AGFE A WDV H M S DL LA G RVH LD E FRG L A AC 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1115 GGFSY A DVLG SA KGWA AAVT F H PR AGAELRR F R KRPDTFSLGVCNGCQ L L A - LL G W VG G DP N EDA aemgpdsqparpgl L 1193
Cdd:TIGR01735 1108 GGFSY G DVLG AG KGWA KSIL F N PR LRDQFQA F F KRPDTFSLGVCNGCQ M L S n LL E W IP G TE N WPH -------------- F 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1194 L R H N l S G R Y E S R W ASVRVG PG P AL MLRGM E G AV LPV WS AHGEGY V AFSSPELQAQ IE A R GLA P L HWA DDDGNPTE Q YPLN 1273
Cdd:TIGR01735 1174 V R N N - S E R F E A R V ASVRVG ES P SI MLRGM A G SR LPV AV AHGEGY A AFSSPELQAQ AD A S GLA A L RYI DDDGNPTE A YPLN 1252
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1274 PNGSPGG V AGI C SCDGR HLAV MPHPER AV R P WQ WA WRP PPF D TL T ts PWL Q LF I NARNW T 1333
Cdd:TIGR01735 1253 PNGSPGG I AGI T SCDGR VTIM MPHPER VF R A WQ NS WRP EDW D ED T -- PWL R LF R NARNW L 1310
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
24-1332
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 1771.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 24 RK L Q G K LP - ELQGV ETE L C Y NV NWTAEA lp SAE ETKK L M WL FG --- C P - L L LDDVAR E SWLLP G S N DLLL EVGPRL N F S T 98
Cdd:PLN03206 5 RK V Q T K VS n DIVSI ETE Q C F NV GLESPL -- SAE KLET L K WL LR etf E P e N L GTESFL E AKKSE G L N AVVV EVGPRL S F T T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 99 PT STN I VS V C R A T GL GP V D R V E TT RRY R L SFAH P PSAEVEAIAL A TL HDRMTE QHF P H P IQ SF SPESM PEP LN g PINILG 178
Cdd:PLN03206 83 AW STN A VS I C S A C GL TE V T R L E RS RRY L L FSSS P LDESQINAFA A MV HDRMTE CVY P Q P LT SF ESGVV PEP VY - TVPVME 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 179 EGR L ALE KA N Q E L GLA L D SW DLD F YT KR F QE - LQ R N P ST VE A FD L AQSNSEHSRHWFF K G Q L HV DGQ KLVHS LF ESIMS T 257
Cdd:PLN03206 162 EGR A ALE EI N K E M GLA F D EQ DLD Y YT RL F RD d IK R D P TN VE L FD I AQSNSEHSRHWFF S G K L VI DGQ PMPKT LF QMVKD T 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 258 QE s S NPNN - V LK F C DNSSAI Q G KE V RF LRP ED P TR PS RFQQQQGLRHVVF TAETHNFP TG V C P FS GA T TG T GGRIRD VQC 336
Cdd:PLN03206 242 LK - A NPNN s V IG F K DNSSAI R G FV V QP LRP VS P GS PS PLAPVDRDLDILL TAETHNFP CA V A P YP GA E TG A GGRIRD THA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 337 TGRG AH VVAGTAGYC F GNL H I P G YNL PWED P SF Q YP G N F A R PL EVA I E ASNGASDYGNKFGEP VLA G FA R SL G LQ LP D G Q 416
Cdd:PLN03206 321 TGRG SF VVAGTAGYC V GNL R I E G SYA PWED S SF V YP S N L A S PL QIL I D ASNGASDYGNKFGEP LIQ G YT R TF G MR LP N G E 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 417 RREW I KPIMFSGGIG SMEAD H IS K EA P EP GM E VVK V GGP V YRIG V GGGAASS V q V Q G D N TSD LDF G AVQRGD P EM E QK MN 496
Cdd:PLN03206 401 RREW L KPIMFSGGIG QIDHT H LT K GE P DI GM L VVK I GGP A YRIG M GGGAASS M - V S G Q N DAE LDF N AVQRGD A EM S QK LY 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 497 RV I RACVE APKG NPI C S L HDQGAGGN G NV L KE LSD P A GA I I YTSRFQL GD P TL NA LEIWGAEYQE SN ALL LRSPN RD F L T 576
Cdd:PLN03206 480 RV V RACVE MGED NPI V S I HDQGAGGN C NV V KE IIY P K GA E I DIRAVVV GD H TL SV LEIWGAEYQE QD ALL IKPES RD L L Q 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 577 HVSA RERC PACFV GTI T G DR R I VLV d D REC P VRRNGQ G DA PP tpl P TP VDL E LE W VLG K MP R K E F FLQ R KPPM L Q PL AL P 656
Cdd:PLN03206 560 SICD RERC SMAVI GTI D G SG R V VLV - D SAA P EKCEAN G LP PP --- P PA VDL D LE K VLG D MP Q K T F EFK R VANK L E PL DI P 635
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 657 PG LS V HQ AL E RVLRLP A V A SKR Y LT N KVDR S V G GLVAQQQ C VGPLQ T PLADVAV V A LS H EE L I G A A T A L GEQP V K S L L DP 736
Cdd:PLN03206 636 PG IT V MD AL K RVLRLP S V C SKR F LT T KVDR C V T GLVAQQQ T VGPLQ I PLADVAV I A QT H TG L T G G A C A I GEQP I K G L V DP 715
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 737 K VA ARLAV A EALTNLV F A L VT D L R DVK C SGNWM W AAKL P GEGA ALA DA CE A MVAV M AA LGVA V DGGKDSLSMAA RV G T E T 816
Cdd:PLN03206 716 K AM ARLAV G EALTNLV W A K VT A L S DVK A SGNWM Y AAKL D GEGA DMY DA AV A LRDA M IE LGVA I DGGKDSLSMAA QA G G E V 795
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 817 V R APG S LVISAY AV CPDIT A TVTPDLK HP e GR G H LL Y V A L SP G QH RLGG T ALAQ CFS Q L G EHP PDLD LPEN L VR AF SI TQ 896
Cdd:PLN03206 796 V K APG N LVISAY VT CPDIT K TVTPDLK LG - DD G V LL H V D L GK G KR RLGG S ALAQ AYD Q I G DDC PDLD DVAY L KK AF EA TQ 874
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 897 G L LKD RL LCS GHD V SDGGLV TC LLEMAFAGNCG LQ VD V P VPRVDVLSV LFAEE P GLVLEV QEPD L AQ V LKRYRD AG LHCL 976
Cdd:PLN03206 875 D L IAK RL ISA GHD I SDGGLV VT LLEMAFAGNCG IN VD L P SSGHSAFET LFAEE L GLVLEV SRKN L DA V MEKLAA AG VTAE 954
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 977 EL G HT g E A G P ha MVR V S V N GA VV L E E PVGE LR AL WEETSFQL DR LQ AEPR CVA E E ER GL RE R MG P SYC L P -- P T F PKASV 1054
Cdd:PLN03206 955 VI G QV - T A S P -- LIE V K V D GA TC L S E KTAS LR DM WEETSFQL EK LQ RLES CVA Q E KE GL KS R KA P TWK L S ft P A F TDKKI 1031
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1055 PREPG gp S P R VAI L REEGSNGDREMA D AF HL AGFE V WDVTM Q DL CS G A I G LD T FRG VA FVGGFSYADVL G SAKGWA AAVT 1134
Cdd:PLN03206 1032 MNATS -- K P K VAI I REEGSNGDREMA A AF YA AGFE P WDVTM S DL LN G R I S LD D FRG IV FVGGFSYADVL D SAKGWA GSIR 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1135 F HPRAGAELRR F RK RPDTFSLGVCNGCQL L ALLGWV G G DPNEDAAEM G P D sq P AR P GLL lr HN L SGR Y E S R WA SV RVGPG 1214
Cdd:PLN03206 1110 F NEPLLQQFQE F YN RPDTFSLGVCNGCQL M ALLGWV P G PQVGGGLGA G G D -- P SQ P RFV -- HN E SGR F E C R FT SV TIEDS 1185
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1215 PA L ML R GMEG AV L P VW S AHGEG YVA F SSPELQAQIEARG LAP LHWA DDDG N PTEQYP L NPNGSP G G V A GI CS C DGRHLA V 1294
Cdd:PLN03206 1186 PA I ML K GMEG ST L G VW A AHGEG RAY F PDESVLDEVLKSN LAP VRYC DDDG E PTEQYP F NPNGSP L G I A AL CS P DGRHLA M 1265
1290 1300 1310 1320
....*....|....*....|....*....|....*....|
gi 1370471312 1295 MPHPER AVRP WQ WA W R P PPF -- D TLTT SPWL QL F I NAR N W 1332
Cdd:PLN03206 1266 MPHPER CFLM WQ FP W Y P KEW gv D PAGP SPWL KM F Q NAR E W 1305
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
177-1023
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 658.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 177 L GE GR L ALE K AN Q ELGLAL DSWDL D FYTKR fqe L Q RNP ST VE AFDLA Q SN SEH SRHWFFKGQ L hvdgqklvh SLFES ims 256
Cdd:COG0046 6 L EG GR E ALE E AN R ELGLAL SDDEY D YIVEI --- L G RNP TD VE LGMFS Q MW SEH CSYKSSNAL L --------- KSLPT --- 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 257 tqes SN P NNVLKFC DN SSAIQGKE vrflrpedptrpsrfqqqq GL r H VVF TA E T HN F P TGVC P FS GA T TG T GG R IRD VQ c 336
Cdd:COG0046 71 ---- EG P RVLSGPG DN AGVVDIGD ------------------- GL - A VVF KV E S HN H P SAIE P YQ GA A TG V GG I IRD IF - 125
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 337 t G R GA HVV AG TAGYC FGNL HI P G ynlpwedpsfqypgnf A R P LEVA I EASN G AS DYGN K FG E P VLA G FA R S lglqlp D GQ 416
Cdd:COG0046 126 - G M GA RPI AG LDSLR FGNL DQ P P ---------------- A S P RYIL I GVVA G IA DYGN C FG V P TVG G EV R F ------ D ES 182
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 417 RRE wi K P IMFS GG I G SME ADHI S K - E AP EP G ME VV K VGGP VY R I G V GG GAAS S V q VQ G DN t S D LD FG AVQ R GDP E ME QKM 495
Cdd:COG0046 183 YEG -- N P LVNA GG V G IIR ADHI F K a K AP GV G NK VV Y VGGP TG R D G I GG ATFA S E - EL G ED - S E LD RP AVQ V GDP F ME KRL 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 496 NRV I RACVEA pkg NP I CSLH D Q GAGG NGNVLK E LSDPA -- GA I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLRSPNRD 573
Cdd:COG0046 259 IEA I LELGDT --- GL I VGIQ D M GAGG LSSASS E MAAKG gl GA E I DLDKVP L RE P GMSPY EIW LS E S QE RML L VVKPEKLE 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 574 FLTHVSA R E R C PA CFV G TI T G D R R I V LV D DR E cpvrrngqgdapptplp T PV DL E L EWVL G KM P RKEFFLQ R k P PM L Q PL 653
Cdd:COG0046 336 EFEAIFE R W R L PA AVI G EV T D D G R L V VT D HG E ----------------- T VA DL P L DFLA G GA P KYHRPAK R - P AY L E PL 397
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 654 A LP PGLSVHQ AL E R V L RL P A VASK RY L TNKV DR S VGG LVAQQQ cvgplqt PL AD V AVV ALSHEEL i G A A TAL GE Q P VKS L 733
Cdd:COG0046 398 D LP EPIDLEE AL L R L L SS P N VASK EW L YRQY DR E VGG NTVRDP ------- GV AD A AVV RVDGTYK - G L A MST GE N P RYA L 469
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 734 LDP KVA AR L AVAEA LT NL VFALVTD L r DVKCSG NW MWAA K l P G E G A A L AD A CEAMVAVMA ALG VA V DG G KD SL SMAARV G 813
Cdd:COG0046 470 LDP YAG AR M AVAEA AR NL AAVGAEP L - AITDCL NW GNPE K - P E E M A Q L VE A VKGLADACR ALG IP V PS G NV SL YNETKD G 547
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 814 TETV ra P GSL VI S A YAVCP D ITA TVTPDLK HP egr G H LLY V a LSPGQHR LGG TAL AQ CFS QLG EH PPD L D l P E NLVRA F S 893
Cdd:COG0046 548 KVAI -- P PTP VI G A VGLVD D VRK TVTPDLK KE --- G D LLY L - IGETKNE LGG SEY AQ VLG QLG GE PPD V D - L E AEKAL F E 620
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 894 IT Q G L LKDR L LCSG HDVSDGGL VTC L L EMAFAG NC G LQ - VDVPVPRVDVLSV LF A E EP G - L V LE V QEP D LAQ V LKRYRD A 971
Cdd:COG0046 621 AV Q E L IREG L ILAA HDVSDGGL AVA L A EMAFAG GL G AD i DLDALGDLRPDAA LF S E SQ G r A V VQ V APE D AEA V EALLAE A 700
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|..
gi 1370471312 972 GL HCLEL G HTGEAG pha MVRVSVN G AVV L EEPVG ELR AL WEET sfq L D RL QA 1023
Cdd:COG0046 701 GL PAHVI G TVTGDD --- RLVIRRG G ETL L SLSLA ELR DA WEET --- L P RL RD 746
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1063-1332
2.06e-135
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 414.97
E-value: 2.06e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1063 PRVAILRE E G S NG DR EMA D AF HL AGF EVW DV T M Q DL C SG AIG LD T F R G V A FV GGFSY A DVLGS A KGWAA AVT F H P RAGAE 1142
Cdd:pfam13507 2 PRVAILRE P G T NG EY EMA A AF ER AGF DAV DV H M S DL L SG RVS LD D F Q G L A AP GGFSY G DVLGS G KGWAA SIL F N P KLRDA 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1143 LRR F RK RPDTFSLG V CNGCQLL AL LG WVG G DPNED A A emgpd SQ P A rpgll L RH N L SGR Y ESRW AS V RVGPG - P ALM LRG 1221
Cdd:pfam13507 82 FEA F FN RPDTFSLG I CNGCQLL SK LG LIP G GEGDL A E ----- RW P T ----- L TR N D SGR F ESRW VN V KISEK s P SVF LRG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1222 M E G AV LPV ws AHGEG YVA F S S P E LQ A QI EA R G LAP L HWA D DD GNPTE Q YP L NPNGSP G G V AGICS C DGR H L AV MPHPER A 1301
Cdd:pfam13507 152 M D G SG LPV -- AHGEG RFV F R S E E VL A RL EA N G QVA L RYV D NA GNPTE E YP F NPNGSP L G I AGICS P DGR V L GL MPHPER V 229
250 260 270
....*....|....*....|....*....|.
gi 1370471312 1302 V RPWQW AWR PP PFDT l TT SPWL Q LF I NAR N W 1332
Cdd:pfam13507 230 F RPWQW PHW PP GEWE - EV SPWL R LF R NAR K W 259
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
218-608
5.49e-123
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 384.13
E-value: 5.49e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 218 E AFDL AQ SN SEH S RH WF FK gqlhvdgqklvh SL FES I M stqessnpnnvlkfcdnssaiqgkevrflrpedptrpsrfqq 297
Cdd:cd02203 1 E LGMF AQ MW SEH C RH KS FK ------------ SL LKM I W ------------------------------------------ 26
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 298 qqglr H VVF TA ETHN F P TGVC PF S GA T TG T GG R IRD VQCT G rg A HVV A GTA G YC FG N L H IPGY nlpwedpsfq Y P GNFAR 377
Cdd:cd02203 27 ----- A VVF KV ETHN H P SAIE PF G GA A TG V GG I IRD ILSM G -- A RPI A LLD G LR FG D L D IPGY ---------- E P KGKLS 89
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 378 P LEVAIEASN G A SDYGN KF G E P VLA G FA R S lglqlp D GQR re WIK P IMFS G GI G SMEA DHI S K - E AP E PG ME VV K VGG PV 456
Cdd:cd02203 90 P RRILDGVVA G I SDYGN CI G I P TVG G EV R F ------ D PSY -- YGN P LVNV G CV G IVPK DHI V K s K AP G PG DL VV L VGG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 457 Y R I G V GG GAA SS VQV q GD N T S D LD FG AVQ R GDP E ME Q K MNRV I RACV E A pkg NP I CSLH D Q GAGG NGNVLK E LSD -- PA G 534
Cdd:cd02203 162 G R D G I GG ATF SS KEL - SE N S S E LD RP AVQ V GDP F ME K K LQEA I LEAR E T --- GL I VGIQ D L GAGG LSSAVS E MAA kg GL G 237
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370471312 535 A I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLRSPNRDFLTHVSAR E RCP A CFV G TI T G D R R IV L VDDR E CPV 608
Cdd:cd02203 238 A E I DLDKVP L RE P GMSPW EIW IS E S QE RML L VVPPEDLEEFLAICKK E DLE A AVI G EV T D D G R LR L YYKG E VVA 311
Name
Accession
Description
Interval
E-value
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
7-1333
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2200.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 7 F YVR PS GHE G AAPGHTRR KLQ G K L PEL Q GV ET E L CY N V N W TAEALPSA EE TKK L MW L F G CP L LLDD vare S W L LP G sndl 86
Cdd:TIGR01735 1 F LRG PS ALS G FRLEKLLQ KLQ T K V PEL T GV YA E F CY F V G W ESALTADE EE KLQ L LL L A G SV L EPPQ ---- S P L GR G ---- 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 87 LLEVGPRL NFST P T S TNIV S VC R AT GL GP VDR V E TT RRY R LS F AHP P S A E V EA I A L A T LHDRMTE QHF PH P I QS F SPE S M 166
Cdd:TIGR01735 73 LLEVGPRL GTIS P W S SKAT S IA R NC GL AK VDR I E RG RRY Y LS G AHP L S E E Q EA Q A A A L LHDRMTE SVL PH E I EA F ELF S V 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 167 PEPLN G - P I NI LG E GRLALEKANQELGLALD SWDL D FY TKRFQELQRNPS T VE AFDL AQ S NSEH S RH WF F KGQLHV DG Q K 245
Cdd:TIGR01735 153 PEPLN L t T I DV LG G GRLALEKANQELGLALD EDEI D YL TKRFQELQRNPS D VE LMMF AQ A NSEH C RH KI F NADWII DG K K 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 246 LVH SLF ES I M ST Q E SSNP N N V LKFC DNSS A I Q G KE V RF LRP ED PTRP SRF Q Q Q QG L R H VVFTA ETHN F PT GVC PF S GA T T 325
Cdd:TIGR01735 233 QDK SLF QM I K ST H E ANPE N T V SAYK DNSS V I E G HK V GR LRP DP PTRP EYR Q H Q ED L V H ILMKV ETHN H PT AIA PF P GA S T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 326 G T GG R IRD VQC TGRGA HVV AG TA G Y C FG NL H IPG YNL PWEDP s FQ Y P GNF A R PL EVA IEA SN GA SDYG N K FG E P V L A G FA 405
Cdd:TIGR01735 313 G A GG E IRD EGA TGRGA KPK AG LT G F C VS NL N IPG LEQ PWEDP - FQ K P ERI A S PL DIM IEA PL GA AAFN N E FG R P N L L G YF 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 406 R SLG L Q -- LP D GQ R R EWI KPIM FS GGIGS ME A D HI S K EAP EPG MEVVKV GGP VYR IG V GGGAASS v Q V Q G D NT S DLDF GA 483
Cdd:TIGR01735 392 R TFE L K as LP G GQ V R GYH KPIM LA GGIGS ID A E HI Q K GEI EPG ALLIVL GGP AML IG L GGGAASS - M V S G T NT A DLDF AS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 484 VQRG D PEME QKMNR VI RA C VEAPKG NPI C S L HD Q GAGG NG N V L K EL SDPA -- GA I I YTSRFQ L G DP T L NA LEIW GA E Y QE 561
Cdd:TIGR01735 471 VQRG N PEME RRCQE VI DR C WQLGEK NPI I S I HD V GAGG LS N A L P EL IHDG gr GA V I DLRAVP L D DP G L SP LEIW CN E S QE 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 562 SNA LL L R SP N RDFL T HVSA RERCP ACF VGT I TGD R R IV LVDD re C PVRRNGQGDAP PTPLPT PVDL E LE WV LGKMP RKEF 641
Cdd:TIGR01735 551 RYV LL V R AE N LEIF T AICE RERCP FAV VGT A TGD G R LT LVDD -- T PVRRNGQGDAP SHFPNN PVDL P LE VL LGKMP KMTR 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 642 F L QRK P PMLQPL AL PPGL SV H Q ALERVLRLPAVASKR Y L TNKV DRSVGGLVA QQ Q C VGP L QTPLADVAV V A L S HEELI G A 721
Cdd:TIGR01735 629 F V QRK A PMLQPL DI PPGL DL H E ALERVLRLPAVASKR F L ITIG DRSVGGLVA RD Q M VGP W QTPLADVAV T A A S FDTYT G E 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 722 A T A L GE Q P V K S LLDPK VA ARLAV A EA L TNL VF ALV T DL R DVK C S G NWM W AA KL PGE G AAL A DA CE A MVAVMA ALG V A VDG 801
Cdd:TIGR01735 709 A M A I GE R P P K A LLDPK AS ARLAV G EA I TNL AA ALV G DL S DVK L S A NWM A AA GH PGE D AAL Y DA VK A VSELCP ALG I A IPV 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 802 GKDSLSM AA R VG ---- T ET V R APGSLVISA Y A VC PD ITA TVTPDLKH PE G RG HLL Y V A L S PG QH RLGG T ALAQ C F S QLG E 877
Cdd:TIGR01735 789 GKDSLSM KT R WQ dnge T KS V T APGSLVISA F A PV PD VRK TVTPDLKH DK G DS HLL L V D L G PG KN RLGG S ALAQ V F G QLG G 868
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 878 HP PDLD L PE N L VRA F SIT QGL LKDR LL CSG HD V SDGGLVT C LLEMAFAG N CGL Q VD VPVPRVDVLS VLF A EE P G L V LE V Q 957
Cdd:TIGR01735 869 DC PDLD D PE R L KAF F AVM QGL VAEG LL LAY HD R SDGGLVT T LLEMAFAG H CGL D VD LDALGDSLFA VLF N EE L G A V IQ V A 948
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 958 E PDLA Q VL KRY R D AGL HC L E LG HTGEA G p H A M V R V SVNGA VV L E E PVG ELR AL WEETSFQL D RL QAE P R C VA EE ER GLR E 1037
Cdd:TIGR01735 949 K PDLA A VL ELL R A AGL TA L I LG IGTPT G - H P M I R I SVNGA TL L S E KRS ELR DI WEETSFQL Q RL RDN P E C AE EE FE GLR D 1027
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1038 R M GP SYC LP P TF PKASVPRE P G --- G PS P R VAILRE E G S NGDREMA D AF HL AGFE V WDV T M Q DL CS G AIG LD T FRG V A FV 1114
Cdd:TIGR01735 1028 R D GP GLK LP L TF DVNEDIAA P F ink G VK P K VAILRE Q G V NGDREMA A AF DR AGFE A WDV H M S DL LA G RVH LD E FRG L A AC 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1115 GGFSY A DVLG SA KGWA AAVT F H PR AGAELRR F R KRPDTFSLGVCNGCQ L L A - LL G W VG G DP N EDA aemgpdsqparpgl L 1193
Cdd:TIGR01735 1108 GGFSY G DVLG AG KGWA KSIL F N PR LRDQFQA F F KRPDTFSLGVCNGCQ M L S n LL E W IP G TE N WPH -------------- F 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1194 L R H N l S G R Y E S R W ASVRVG PG P AL MLRGM E G AV LPV WS AHGEGY V AFSSPELQAQ IE A R GLA P L HWA DDDGNPTE Q YPLN 1273
Cdd:TIGR01735 1174 V R N N - S E R F E A R V ASVRVG ES P SI MLRGM A G SR LPV AV AHGEGY A AFSSPELQAQ AD A S GLA A L RYI DDDGNPTE A YPLN 1252
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1274 PNGSPGG V AGI C SCDGR HLAV MPHPER AV R P WQ WA WRP PPF D TL T ts PWL Q LF I NARNW T 1333
Cdd:TIGR01735 1253 PNGSPGG I AGI T SCDGR VTIM MPHPER VF R A WQ NS WRP EDW D ED T -- PWL R LF R NARNW L 1310
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
24-1332
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 1771.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 24 RK L Q G K LP - ELQGV ETE L C Y NV NWTAEA lp SAE ETKK L M WL FG --- C P - L L LDDVAR E SWLLP G S N DLLL EVGPRL N F S T 98
Cdd:PLN03206 5 RK V Q T K VS n DIVSI ETE Q C F NV GLESPL -- SAE KLET L K WL LR etf E P e N L GTESFL E AKKSE G L N AVVV EVGPRL S F T T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 99 PT STN I VS V C R A T GL GP V D R V E TT RRY R L SFAH P PSAEVEAIAL A TL HDRMTE QHF P H P IQ SF SPESM PEP LN g PINILG 178
Cdd:PLN03206 83 AW STN A VS I C S A C GL TE V T R L E RS RRY L L FSSS P LDESQINAFA A MV HDRMTE CVY P Q P LT SF ESGVV PEP VY - TVPVME 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 179 EGR L ALE KA N Q E L GLA L D SW DLD F YT KR F QE - LQ R N P ST VE A FD L AQSNSEHSRHWFF K G Q L HV DGQ KLVHS LF ESIMS T 257
Cdd:PLN03206 162 EGR A ALE EI N K E M GLA F D EQ DLD Y YT RL F RD d IK R D P TN VE L FD I AQSNSEHSRHWFF S G K L VI DGQ PMPKT LF QMVKD T 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 258 QE s S NPNN - V LK F C DNSSAI Q G KE V RF LRP ED P TR PS RFQQQQGLRHVVF TAETHNFP TG V C P FS GA T TG T GGRIRD VQC 336
Cdd:PLN03206 242 LK - A NPNN s V IG F K DNSSAI R G FV V QP LRP VS P GS PS PLAPVDRDLDILL TAETHNFP CA V A P YP GA E TG A GGRIRD THA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 337 TGRG AH VVAGTAGYC F GNL H I P G YNL PWED P SF Q YP G N F A R PL EVA I E ASNGASDYGNKFGEP VLA G FA R SL G LQ LP D G Q 416
Cdd:PLN03206 321 TGRG SF VVAGTAGYC V GNL R I E G SYA PWED S SF V YP S N L A S PL QIL I D ASNGASDYGNKFGEP LIQ G YT R TF G MR LP N G E 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 417 RREW I KPIMFSGGIG SMEAD H IS K EA P EP GM E VVK V GGP V YRIG V GGGAASS V q V Q G D N TSD LDF G AVQRGD P EM E QK MN 496
Cdd:PLN03206 401 RREW L KPIMFSGGIG QIDHT H LT K GE P DI GM L VVK I GGP A YRIG M GGGAASS M - V S G Q N DAE LDF N AVQRGD A EM S QK LY 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 497 RV I RACVE APKG NPI C S L HDQGAGGN G NV L KE LSD P A GA I I YTSRFQL GD P TL NA LEIWGAEYQE SN ALL LRSPN RD F L T 576
Cdd:PLN03206 480 RV V RACVE MGED NPI V S I HDQGAGGN C NV V KE IIY P K GA E I DIRAVVV GD H TL SV LEIWGAEYQE QD ALL IKPES RD L L Q 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 577 HVSA RERC PACFV GTI T G DR R I VLV d D REC P VRRNGQ G DA PP tpl P TP VDL E LE W VLG K MP R K E F FLQ R KPPM L Q PL AL P 656
Cdd:PLN03206 560 SICD RERC SMAVI GTI D G SG R V VLV - D SAA P EKCEAN G LP PP --- P PA VDL D LE K VLG D MP Q K T F EFK R VANK L E PL DI P 635
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 657 PG LS V HQ AL E RVLRLP A V A SKR Y LT N KVDR S V G GLVAQQQ C VGPLQ T PLADVAV V A LS H EE L I G A A T A L GEQP V K S L L DP 736
Cdd:PLN03206 636 PG IT V MD AL K RVLRLP S V C SKR F LT T KVDR C V T GLVAQQQ T VGPLQ I PLADVAV I A QT H TG L T G G A C A I GEQP I K G L V DP 715
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 737 K VA ARLAV A EALTNLV F A L VT D L R DVK C SGNWM W AAKL P GEGA ALA DA CE A MVAV M AA LGVA V DGGKDSLSMAA RV G T E T 816
Cdd:PLN03206 716 K AM ARLAV G EALTNLV W A K VT A L S DVK A SGNWM Y AAKL D GEGA DMY DA AV A LRDA M IE LGVA I DGGKDSLSMAA QA G G E V 795
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 817 V R APG S LVISAY AV CPDIT A TVTPDLK HP e GR G H LL Y V A L SP G QH RLGG T ALAQ CFS Q L G EHP PDLD LPEN L VR AF SI TQ 896
Cdd:PLN03206 796 V K APG N LVISAY VT CPDIT K TVTPDLK LG - DD G V LL H V D L GK G KR RLGG S ALAQ AYD Q I G DDC PDLD DVAY L KK AF EA TQ 874
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 897 G L LKD RL LCS GHD V SDGGLV TC LLEMAFAGNCG LQ VD V P VPRVDVLSV LFAEE P GLVLEV QEPD L AQ V LKRYRD AG LHCL 976
Cdd:PLN03206 875 D L IAK RL ISA GHD I SDGGLV VT LLEMAFAGNCG IN VD L P SSGHSAFET LFAEE L GLVLEV SRKN L DA V MEKLAA AG VTAE 954
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 977 EL G HT g E A G P ha MVR V S V N GA VV L E E PVGE LR AL WEETSFQL DR LQ AEPR CVA E E ER GL RE R MG P SYC L P -- P T F PKASV 1054
Cdd:PLN03206 955 VI G QV - T A S P -- LIE V K V D GA TC L S E KTAS LR DM WEETSFQL EK LQ RLES CVA Q E KE GL KS R KA P TWK L S ft P A F TDKKI 1031
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1055 PREPG gp S P R VAI L REEGSNGDREMA D AF HL AGFE V WDVTM Q DL CS G A I G LD T FRG VA FVGGFSYADVL G SAKGWA AAVT 1134
Cdd:PLN03206 1032 MNATS -- K P K VAI I REEGSNGDREMA A AF YA AGFE P WDVTM S DL LN G R I S LD D FRG IV FVGGFSYADVL D SAKGWA GSIR 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1135 F HPRAGAELRR F RK RPDTFSLGVCNGCQL L ALLGWV G G DPNEDAAEM G P D sq P AR P GLL lr HN L SGR Y E S R WA SV RVGPG 1214
Cdd:PLN03206 1110 F NEPLLQQFQE F YN RPDTFSLGVCNGCQL M ALLGWV P G PQVGGGLGA G G D -- P SQ P RFV -- HN E SGR F E C R FT SV TIEDS 1185
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1215 PA L ML R GMEG AV L P VW S AHGEG YVA F SSPELQAQIEARG LAP LHWA DDDG N PTEQYP L NPNGSP G G V A GI CS C DGRHLA V 1294
Cdd:PLN03206 1186 PA I ML K GMEG ST L G VW A AHGEG RAY F PDESVLDEVLKSN LAP VRYC DDDG E PTEQYP F NPNGSP L G I A AL CS P DGRHLA M 1265
1290 1300 1310 1320
....*....|....*....|....*....|....*....|
gi 1370471312 1295 MPHPER AVRP WQ WA W R P PPF -- D TLTT SPWL QL F I NAR N W 1332
Cdd:PLN03206 1266 MPHPER CFLM WQ FP W Y P KEW gv D PAGP SPWL KM F Q NAR E W 1305
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
24-1332
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 1447.30
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 24 RK LQ GKLPELQGVET E LCYNVN wt AE A LP SAEE TK KL MW L FG cplll DDV A RES wllpg SNDL L LE V G PR LNFST P T S TN 103
Cdd:PRK05297 20 AR LQ AAVLPVTSIYA E YVHFAD -- LS A PL SAEE QA KL ER L LT ----- YGP A EHE ----- PAGR L FL V T PR PGTIS P W S SK 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 104 IVSVCRAT GL GPVD R V E TTRR Y RLSF ah PP SAE VE A IAL A T LHDRMTE QH F PHPIQ -- SFSPESM P E PL NG p INI LG E GR 181
Cdd:PRK05297 88 ATDIAHNC GL AGIR R I E RGIA Y YVEA -- AL SAE QR A ALA A L LHDRMTE SV F ADLDD ae ALFSHHE P K PL TS - VDV LG G GR 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 182 L ALE K AN Q ELGLAL DSWDL D FYTKR F QE L Q RNP ST VE AFDL AQ S NSEH S RH WF F KGQLHV DG QKLVH SLF ES I MS T Q E S s 261
Cdd:PRK05297 165 A ALE A AN V ELGLAL AEDEI D YLVEA F TK L G RNP TD VE LMMF AQ A NSEH C RH KI F NADWTI DG EEQPK SLF KM I KN T H E T - 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 262 NP NN VL K - FC DN SSAIQ G KE V - RF L - R P EDP trps R FQQQ Q GLR H VVFTA ETHN F PT GVC PF S GA T TG T GG R IRD VQC TG 338
Cdd:PRK05297 244 NP DG VL S a YK DN AAVME G SK V g RF F p D P DTG ---- R YGYH Q EPA H ILMKV ETHN H PT AIS PF P GA A TG S GG E IRD EGA TG 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 339 RG AHVV AG TA G YCFG NL H IPG YNL PWE DP s FQY P GNF A RP L EVA IE ASN G ASDYG N K FG E P V L A G FA R SLGLQLPDG -- Q 416
Cdd:PRK05297 320 RG SKPK AG LT G FSVS NL R IPG FEQ PWE ED - YGK P ERI A SA L DIM IE GPL G GAAFN N E FG R P N L L G YF R TFEQKVNSH ne E 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 417 R R EWI KPIM FS GGIG SME ADH IS K EAPEP G MEVVKV GGP VY RIG V GGGAASS V q VQ G DNTS DLDF GA VQRG D PEME QKMN 496
Cdd:PRK05297 399 V R GYH KPIM LA GGIG NIR ADH VQ K GEIPV G AKLIVL GGP AM RIG L GGGAASS M - AS G QSSE DLDF AS VQRG N PEME RRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 497 R VI RA C VEAPKG NPI C S L HD Q GAGG NG N VLK EL SDPA -- G AIIYTSRFQLGD P TLNA LEIW GA E Y QE SNA L LLRSPNRDF 574
Cdd:PRK05297 478 E VI DR C WQLGDD NPI L S I HD V GAGG LS N AFP EL VNDG gr G GRFDLRKIPNDE P GMSP LEIW CN E S QE RYV L AIAPEDLEL 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 575 LTHVSA RERCP ACF VG TI T GD R RIV L V D drecpvrrn GQG D A pptplp T PVDL E L EWV LGK M P RKEFFLQRKPPMLQP L A 654
Cdd:PRK05297 558 FEAICE RERCP FAV VG EA T EE R HLT L E D --------- SHF D N ------ K PVDL P L DVL LGK P P KMHRDVKTVKAKGPA L D 622
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 655 LP p G LSVHQ A L ERVLRLP A VASK RY L TNKV DRSV G GLVA QQ Q C VGP L Q T P L AD V AV V A L S HEELI G A A T A L GE QPVKS LL 734
Cdd:PRK05297 623 YS - G IDLAE A V ERVLRLP T VASK SF L ITIG DRSV T GLVA RD Q M VGP W Q V P V AD C AV T A A S YDGYA G E A M A M GE RTPVA LL 701
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 735 D PKVA AR L AV A EALTN LVF A LVT DL RDV K C S G NWM W AA KL PGE G A A L A DA CE A MVAVMA - ALG VAVDG GKDSLSM AARV - 812
Cdd:PRK05297 702 D AAAS AR M AV G EALTN IAA A PIG DL KRI K L S A NWM A AA GH PGE D A R L Y DA VK A VGMELC p ALG ITIPV GKDSLSM KTKW q 781
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 813 --- GTET V RA P G SL V ISA Y A VCP D ITA T V TP D L KHPEG r GH LL YVA L SP G QH RLGG T ALAQ CFS QLG EHP PD L D LP E N L V 889
Cdd:PRK05297 782 egg EDKE V TS P L SL I ISA F A PVE D VRK T L TP Q L RTDKD - TA LL LID L GR G KN RLGG S ALAQ VYN QLG DKA PD V D DA E D L K 860
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 890 RA F SIT Q G L LKDR LL CSG HD V SDGGL V T C L L EMAFAG N CGL QV D VPVPRV D V L SV LF A EE P G L V LE V QEP D LAQ V LKRYR 969
Cdd:PRK05297 861 GF F NAI Q A L VAEG LL LAY HD R SDGGL L T T L A EMAFAG H CGL DI D LDALGD D A L AA LF N EE L G A V IQ V RAA D RDA V EAILA 940
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 970 DA GL -- HCLEL G HTGEAG pha MVRVSV NG AV V LE E PVG ELR AL W E ETS F Q LD RL QAE P R C VAE E ERGLRERMG P SYCLPP 1047
Cdd:PRK05297 941 EH GL sd CVHVI G KPNAGD --- RIVITR NG KT V FS E SRT ELR RW W S ETS Y Q MQ RL RDN P E C ADQ E FDAILDQAD P GLNVKL 1017
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1048 TF --- PKASV P REPG G PS P R VAILRE E G S N GDR EMA D AF HL AGF EVW DV T M Q DL CS G AIG L DT F R G VAFV GGFSY A DVLG 1124
Cdd:PRK05297 1018 TF dpn EDIAA P FIAT G AR P K VAILRE Q G V N SHV EMA A AF DR AGF DAI DV H M S DL LA G RVT L ED F K G LVAC GGFSY G DVLG 1097
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1125 SAK GWA AAVT F H PR AGAELRR F RK RPDTF S LGVCNGCQ LLAL L gwvggdpneda A E MG P DSQ p AR P GLL lr H N L S GRY E S 1204
Cdd:PRK05297 1098 AGE GWA KSIL F N PR LRDQFEA F FA RPDTF A LGVCNGCQ MMSN L ----------- K E II P GAE - HW P RFV -- R N R S EQF E A 1163
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1205 R WAS V R V GPG P ALM L R GM E G AV LP VWS AHGEG YVA F SSPE L Q A q I EA R GL AP L HWA D DD G NP TE Q YP L NPNGSP G G VA G I 1284
Cdd:PRK05297 1164 R FSL V E V QES P SIF L Q GM A G SR LP IAV AHGEG RAE F PDAH L A A - L EA K GL VA L RYV D NH G QV TE T YP A NPNGSP N G IT G L 1242
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*...
gi 1370471312 1285 CSC DGR HLAV MPHPER AV R PW Q WA W R P PPFDTL tt SPW LQL F I NAR N W 1332
Cdd:PRK05297 1243 TTA DGR VTIM MPHPER VF R TV Q NS W H P EEWGED -- SPW MRM F R NAR K W 1288
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
177-1023
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 658.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 177 L GE GR L ALE K AN Q ELGLAL DSWDL D FYTKR fqe L Q RNP ST VE AFDLA Q SN SEH SRHWFFKGQ L hvdgqklvh SLFES ims 256
Cdd:COG0046 6 L EG GR E ALE E AN R ELGLAL SDDEY D YIVEI --- L G RNP TD VE LGMFS Q MW SEH CSYKSSNAL L --------- KSLPT --- 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 257 tqes SN P NNVLKFC DN SSAIQGKE vrflrpedptrpsrfqqqq GL r H VVF TA E T HN F P TGVC P FS GA T TG T GG R IRD VQ c 336
Cdd:COG0046 71 ---- EG P RVLSGPG DN AGVVDIGD ------------------- GL - A VVF KV E S HN H P SAIE P YQ GA A TG V GG I IRD IF - 125
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 337 t G R GA HVV AG TAGYC FGNL HI P G ynlpwedpsfqypgnf A R P LEVA I EASN G AS DYGN K FG E P VLA G FA R S lglqlp D GQ 416
Cdd:COG0046 126 - G M GA RPI AG LDSLR FGNL DQ P P ---------------- A S P RYIL I GVVA G IA DYGN C FG V P TVG G EV R F ------ D ES 182
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 417 RRE wi K P IMFS GG I G SME ADHI S K - E AP EP G ME VV K VGGP VY R I G V GG GAAS S V q VQ G DN t S D LD FG AVQ R GDP E ME QKM 495
Cdd:COG0046 183 YEG -- N P LVNA GG V G IIR ADHI F K a K AP GV G NK VV Y VGGP TG R D G I GG ATFA S E - EL G ED - S E LD RP AVQ V GDP F ME KRL 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 496 NRV I RACVEA pkg NP I CSLH D Q GAGG NGNVLK E LSDPA -- GA I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLRSPNRD 573
Cdd:COG0046 259 IEA I LELGDT --- GL I VGIQ D M GAGG LSSASS E MAAKG gl GA E I DLDKVP L RE P GMSPY EIW LS E S QE RML L VVKPEKLE 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 574 FLTHVSA R E R C PA CFV G TI T G D R R I V LV D DR E cpvrrngqgdapptplp T PV DL E L EWVL G KM P RKEFFLQ R k P PM L Q PL 653
Cdd:COG0046 336 EFEAIFE R W R L PA AVI G EV T D D G R L V VT D HG E ----------------- T VA DL P L DFLA G GA P KYHRPAK R - P AY L E PL 397
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 654 A LP PGLSVHQ AL E R V L RL P A VASK RY L TNKV DR S VGG LVAQQQ cvgplqt PL AD V AVV ALSHEEL i G A A TAL GE Q P VKS L 733
Cdd:COG0046 398 D LP EPIDLEE AL L R L L SS P N VASK EW L YRQY DR E VGG NTVRDP ------- GV AD A AVV RVDGTYK - G L A MST GE N P RYA L 469
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 734 LDP KVA AR L AVAEA LT NL VFALVTD L r DVKCSG NW MWAA K l P G E G A A L AD A CEAMVAVMA ALG VA V DG G KD SL SMAARV G 813
Cdd:COG0046 470 LDP YAG AR M AVAEA AR NL AAVGAEP L - AITDCL NW GNPE K - P E E M A Q L VE A VKGLADACR ALG IP V PS G NV SL YNETKD G 547
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 814 TETV ra P GSL VI S A YAVCP D ITA TVTPDLK HP egr G H LLY V a LSPGQHR LGG TAL AQ CFS QLG EH PPD L D l P E NLVRA F S 893
Cdd:COG0046 548 KVAI -- P PTP VI G A VGLVD D VRK TVTPDLK KE --- G D LLY L - IGETKNE LGG SEY AQ VLG QLG GE PPD V D - L E AEKAL F E 620
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 894 IT Q G L LKDR L LCSG HDVSDGGL VTC L L EMAFAG NC G LQ - VDVPVPRVDVLSV LF A E EP G - L V LE V QEP D LAQ V LKRYRD A 971
Cdd:COG0046 621 AV Q E L IREG L ILAA HDVSDGGL AVA L A EMAFAG GL G AD i DLDALGDLRPDAA LF S E SQ G r A V VQ V APE D AEA V EALLAE A 700
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|..
gi 1370471312 972 GL HCLEL G HTGEAG pha MVRVSVN G AVV L EEPVG ELR AL WEET sfq L D RL QA 1023
Cdd:COG0046 701 GL PAHVI G TVTGDD --- RLVIRRG G ETL L SLSLA ELR DA WEET --- L P RL RD 746
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1063-1332
2.06e-135
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 414.97
E-value: 2.06e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1063 PRVAILRE E G S NG DR EMA D AF HL AGF EVW DV T M Q DL C SG AIG LD T F R G V A FV GGFSY A DVLGS A KGWAA AVT F H P RAGAE 1142
Cdd:pfam13507 2 PRVAILRE P G T NG EY EMA A AF ER AGF DAV DV H M S DL L SG RVS LD D F Q G L A AP GGFSY G DVLGS G KGWAA SIL F N P KLRDA 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1143 LRR F RK RPDTFSLG V CNGCQLL AL LG WVG G DPNED A A emgpd SQ P A rpgll L RH N L SGR Y ESRW AS V RVGPG - P ALM LRG 1221
Cdd:pfam13507 82 FEA F FN RPDTFSLG I CNGCQLL SK LG LIP G GEGDL A E ----- RW P T ----- L TR N D SGR F ESRW VN V KISEK s P SVF LRG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1222 M E G AV LPV ws AHGEG YVA F S S P E LQ A QI EA R G LAP L HWA D DD GNPTE Q YP L NPNGSP G G V AGICS C DGR H L AV MPHPER A 1301
Cdd:pfam13507 152 M D G SG LPV -- AHGEG RFV F R S E E VL A RL EA N G QVA L RYV D NA GNPTE E YP F NPNGSP L G I AGICS P DGR V L GL MPHPER V 229
250 260 270
....*....|....*....|....*....|.
gi 1370471312 1302 V RPWQW AWR PP PFDT l TT SPWL Q LF I NAR N W 1332
Cdd:pfam13507 230 F RPWQW PHW PP GEWE - EV SPWL R LF R NAR K W 259
PHA03366
PHA03366 FGAM-synthase; Provisional
526-1334
2.02e-125
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 420.97
E-value: 2.02e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 526 L KE L SD P A G AIIYT S R fq L GDPTLNA L EIWG A EYQ E S N ALLLR ------- SPN ----------------- R D F L THVSAR 581
Cdd:PHA03366 439 L LA L CP P G G LLLFL S A -- L PEDVVSG L KPFS A SNR E T N EEIVK qyflnvy CSV vflvikntheggegvtp L D A L KRACRL 516
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 582 ER CP ACFV G TITGDRR I VL V D D REC PV RR ---- NGQGDAP P TPLPT P VDLELEWV lgkmprkeffl QRKP P ML Q PLALP - 656
Cdd:PHA03366 517 AG CP VHIL G RTVPLPG I HF V N D LGN PV YG elrd DQFKPTF P LQPSR P LSPVSATS ----------- EDTR P SP Q DESID w 585
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 657 PGLSVHQA L ERV L RL P A V A SK R Y LTNKV DR SVG G L VAQQ QC VGPL QT P LA D VAV V ------------------------- 711
Cdd:PHA03366 586 ALFNLNST L LQI L SH P T V G SK E Y IVRHI DR CGN G R VAQQ PG VGPL DL P VS D YSI V vhssvktrraietpsstedltyqea 665
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 712 ---------------- ALS H EELI G AAT ALGEQ PV K SL LDP KVA A RL A VA EALTNL VF A L V TD L R D VKCSGNWM W A akl P 775
Cdd:PHA03366 666 delinspltwfdpdde SVL H PAVP G TCS ALGEQ GY K VQ LDP ILG A KY A IV EALTNL ML A P V AN L E D ITITLSVT W P --- P 742
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 776 GEG AA ----- LAD AC EAMVA vma A LGV AV dggkd SLSM A ARVGTETVRAPG ----- SL V IS A Y A VC P DI T ATV TPDLK H P 845
Cdd:PHA03366 743 TDQ AA selyr ALA AC KEFCR --- E LGV NF ----- TFTS A SSSPRQDQPPQP gplfn TI V FT A S A PV P SS T PRL TPDLK K P 814
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 846 eg RGH L LYVAL SP GQH r L G G TALA Q C F SQLGEHP PD LD l P EN L VRA F SIT Q G L LKDR L LC SGHDVSDGGL VT CL L EMA F A 925
Cdd:PHA03366 815 -- GSA L VHLSI SP EYT - L A G SVFE Q I F GLKSGTL PD IS - P SY L KNL F RAV Q H L ISEG L VV SGHDVSDGGL IA CL A EMA L A 890
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 926 G NC G LQ v DVPVPRV D V L SV LF A E E PG L V L EV QEPD L AQ VL K R Y R DAGLH C LEL G HT G EA GP HAMVR VS V NG A V VLE E PVG 1005
Cdd:PHA03366 891 G GR G VT - ITVPAGE D P L QF LF S E T PG V V I EV PPSH L SA VL T R L R SRNII C YPI G TV G PS GP SNTFS VS H NG T V LFR E SLS 969
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1006 E LR AL W ee T SF QLDRLQAEPRCVA EE E ------------- RG L R E -- RMG P SYC lpptfpkasv PRE P GGP s P RVA I L RE 1070
Cdd:PHA03366 970 S LR ST W -- R SF SDEQFELLRPDLT EE S myrkdygnnevdl GP L E E gl TTS P LRL ---------- YTC P DKR - H RVA V L LL 1036
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1071 E G SN G DREMAD AF HL AGF EVWD V TMQD L CS G AI g LD T F R G VAFV G GFSYA D VLGS A KGWA AA VTFH P RAGAE L R RF RK RP 1150
Cdd:PHA03366 1037 P G CP G PHALLA AF TN AGF DPYP V SIEE L KD G TF - LD E F S G LVIG G SSGAE D SYTG A RAAV AA LLSN P AVRDA L L RF LN RP 1115
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1151 DTFSLG VCN - GCQ L L AL L GW VG GD - P NEDAAEMGPDSQ P AR pgll L RH N L SG R YESRW ASVRVGPG - PALM LR GME G A VL 1227
Cdd:PHA03366 1116 DTFSLG CGE l GCQ I L FA L KA VG ST a P SPVPGTETEEQW P IT ---- L EP N A SG L YESRW LNFYIPET t KSVA LR PLR G S VL 1191
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1228 P V W s A H G E -- G y VAFSSPELQAQIEAR G LAPLHWAD --- D D GNP TEQ YP L NP N G S p GG VAG I CS C DGRHLA VMPH P ERAV 1302
Cdd:PHA03366 1192 P C W - A Q G T hl G - FRYPNDGMEYILRNS G QIAATFHG adv D P GNP ARH YP R NP T G N - SN VAG L CS A DGRHLA LLFD P SLSF 1268
890 900 910
....*....|....*....|....*....|..
gi 1370471312 1303 R PWQW AWR PP PFDT L TT SPW LQL F INARN W T L 1334
Cdd:PHA03366 1269 H PWQW QHV PP ENGP L KV SPW KLM F QDLHL W C L 1300
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
218-608
5.49e-123
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 384.13
E-value: 5.49e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 218 E AFDL AQ SN SEH S RH WF FK gqlhvdgqklvh SL FES I M stqessnpnnvlkfcdnssaiqgkevrflrpedptrpsrfqq 297
Cdd:cd02203 1 E LGMF AQ MW SEH C RH KS FK ------------ SL LKM I W ------------------------------------------ 26
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 298 qqglr H VVF TA ETHN F P TGVC PF S GA T TG T GG R IRD VQCT G rg A HVV A GTA G YC FG N L H IPGY nlpwedpsfq Y P GNFAR 377
Cdd:cd02203 27 ----- A VVF KV ETHN H P SAIE PF G GA A TG V GG I IRD ILSM G -- A RPI A LLD G LR FG D L D IPGY ---------- E P KGKLS 89
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 378 P LEVAIEASN G A SDYGN KF G E P VLA G FA R S lglqlp D GQR re WIK P IMFS G GI G SMEA DHI S K - E AP E PG ME VV K VGG PV 456
Cdd:cd02203 90 P RRILDGVVA G I SDYGN CI G I P TVG G EV R F ------ D PSY -- YGN P LVNV G CV G IVPK DHI V K s K AP G PG DL VV L VGG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 457 Y R I G V GG GAA SS VQV q GD N T S D LD FG AVQ R GDP E ME Q K MNRV I RACV E A pkg NP I CSLH D Q GAGG NGNVLK E LSD -- PA G 534
Cdd:cd02203 162 G R D G I GG ATF SS KEL - SE N S S E LD RP AVQ V GDP F ME K K LQEA I LEAR E T --- GL I VGIQ D L GAGG LSSAVS E MAA kg GL G 237
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370471312 535 A I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLRSPNRDFLTHVSAR E RCP A CFV G TI T G D R R IV L VDDR E CPV 608
Cdd:cd02203 238 A E I DLDKVP L RE P GMSPW EIW IS E S QE RML L VVPPEDLEEFLAICKK E DLE A AVI G EV T D D G R LR L YYKG E VVA 311
tegu_FGAM_synt
TIGR01739 herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins ...
397-1334
2.91e-111
herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins of herpesvirues. The protein is described variably as tegument protein or phosphoribosylformylglycinamidine synthase (FGAM-synthase). Most of the length of the protein shows homology to eukaryotic FGAM-synthase. Functional characterizations were not verified during construction of this model.
Pssm-ID: 273784 [Multi-domain]
Cd Length: 1202
Bit Score: 379.04
E-value: 2.91e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 397 G E P VLA GF A R --- SLG L Q LP DGQR rewik P IMFSGGIGSMEADH I SKEAPE PG MEV V KV G -- G P VYR igvgggaa SSVQV 471
Cdd:TIGR01739 237 G V P TCG GF I R lis KNK L S LP TPYT ----- P TYNTSILDRLCHVT I NTADEP PG QDI V AL G qf E P SLL -------- PDTPP 303
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 472 QGDNT S D LD FGAVQ rgdpeme QKMNRVIR acv EAPKGNPIC S LHDQ G AGGNGNV L KE L SD P A GA IIYT S rf Q L G D PTLN A 551
Cdd:TIGR01739 304 LLYAD S P LD VNKIL ------- TALALLTD --- DVKTPCIVG S IRPL G PCSVKEH L TA L LP P C GA ELDL S -- N L P D EVVA A 371
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 552 L EIWGAEYQES N ALLLRS ------ PNRD FLT ----- H VSAR E --------------- R CP ACFV G TITGDRRIVL V D D RE 605
Cdd:TIGR01739 372 L ARSSPANRVE N EKMVKQ yflnvv CSVV FLT vkntp H NTGT E gvtplerlktacrmf G CP VKVL G KLVPLPGLHI V S D LF 451
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 606 C PV rrngqgdapptpl PT PVDLELEWVLGKM P R ke FF L QRKP P M -- LQ P LA L PPG ----- L SVHQALERV L RL P A V A SK R 678
Cdd:TIGR01739 452 N PV ------------- PT YPTFDFTSFTPTS P L -- LP L GGPE P V sr TR P MF L DES lnwqt L NLRSTILKI L SH P T V G SK E 516
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 679 YLTNKV DR SVG G L VAQQQ C VGPL QT P LA D VAV V ALS ---------------------------------- H E E -- L IGAA 722
Cdd:TIGR01739 517 FIVRHI DR CGN G R VAQQQ G VGPL DL P VS D YSL V LHN lsrptdttevtysenamdlildpdswlyswenev L E N pa L SCVC 596
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 723 T ALGEQ PV K SLL DPK VA A RL A VA EAL T NL VFALVTD L R DV KCSGNWM W AAKLP g EGAA L A DA CE A MVAVMAA LGV AV dgg 802
Cdd:TIGR01739 597 S ALGEQ TY K VQA DPK RG A TY A IT EAL L NL SLSPWNT L E DV IITLSVT W SPTDH - VYSL L K DA LR A CKDFCEE LGV SF --- 672
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 803 kd SLSM AA RVG T ETVRAPG -- S L V I SA YAVCPDITATV TPDLK HPEG rg HL LYVA L S P g QHR L G G TALA Q CFSQLGEHP P 880
Cdd:TIGR01739 673 -- TVTS AA SSP T QDSGSAP fm S I V F SA SCPVLLSAKKI TPDLK SHGS -- HL IWLS L H P - SYT L A G SIFE Q ILGLSFIRL P 747
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 881 D L D l P EN L VRAF S IT Q G L L K DRLLC SGHDVSDGGLV T C LL EMA FA G NC G LQVDV P VPRVD v L SV L FA E E PG L V L EV QEPD 960
Cdd:TIGR01739 748 A L S - P VS L KKLL S AL Q T L V K EGVIV SGHDVSDGGLV A C VA EMA LS G GK G VRITL P HGTDP - L EF L CS E T PG V V I EV DPSS 825
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 961 LAQ VL KRY R DA GL HCLEL G HT GE A GP HAMVR V SV N GA V VLE EP VGE L RAL W EET S FQLDR L QAEPRCVA E EERGLRERMG 1040
Cdd:TIGR01739 826 MYA VL QFL R SE GL VFQVI G RV GE S GP SPTFS V VH N ST V LFQ EP LSL L QGT W RSF S DEENT L LCPNLEPR E MHVLDYGYNE 905
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1041 PSYCLP P TFPKA S VP R EPGG P S P -- R VA I L REE G SNGDREMAD A FHL AGF EVWD V TMQD L CSGAI g LDTF R G VAFV G GFS 1118
Cdd:TIGR01739 906 MDFGGV P KGLPL S PL R FFTC P D P rh Q VA V L LLP G QSVPHGLLA A LTN AGF DPRI V SITE L KKTDF - LDTF S G LIIG G ASG 984
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1119 YA D VLGS A KGW AAA VTFHPRAGAE L RR F RK RPDTFSLG VCN - GCQLL AL L GW VG GDPNEDAAEMGPDS Q PARP gll L RH N 1197
Cdd:TIGR01739 985 TL D SEVG A RAL AAA LLRNQAFLRD L LT F LN RPDTFSLG FGE l GCQLL LA L NI VG YTQSSPFITVPTEV Q EPPR --- L EK N 1061
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1198 L SG R YESRW ASVRVGPGP - ALM LR GME G A VLP V W s A H G E -- G y VAFSSPELQAQI E AR G LAPLHWAD --- DD G N P TEQ YP 1271
Cdd:TIGR01739 1062 A SG L YESRW LNFYIPETT k SVF LR PLR G S VLP C W - A Q G T hl G - LYHPDDGVEEEL E NS G QIASTFHG nsp SS G L P ATN YP 1139
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370471312 1272 L NP N G S p GG VAG I CS C DGRHLA VMPH P ERAVR PWQW AWR PP PFDT L TT SPW LQL F INARN W T L 1334
Cdd:TIGR01739 1140 R NP S G G - SN VAG L CS A DGRHLA LLID P SLSFF PWQW QHV PP NNPP L QV SPW KLM F QRLHL W S L 1201
GATase1_FGAR_AT
cd01740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ...
1065-1330
3.27e-99
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain]
Cd Length: 238
Bit Score: 316.48
E-value: 3.27e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1065 VA I LR EE GSN G DR E MA D AF H LAGFE VW DV TMQ DL CS G AIG LD TFR GV AFV GGFSY A D V L GSAKGW AA A vtfh P RAGA E LR 1144
Cdd:cd01740 1 VA V LR FP GSN C DR D MA Y AF E LAGFE AE DV WHN DL LA G RKD LD DYD GV VLP GGFSY G D Y L RAGAIA AA S ---- P LLME E VK 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1145 R F RK R p DTFS LG V CNG C Q L L AL LG WVG G DPNEDAAEMGPD sqparpglllrhnlsg R YES R WASV RV GPGPALMLR G - ME 1223
Cdd:cd01740 77 E F AE R - GGLV LG I CNG F Q I L VE LG LLP G ALIRNKGLKFIC ---------------- R WQN R FVTL RV ENNDSPFTK G y ME 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1224 G A VL PVWS AHGEG YVAFSSPE L QAQI E ARGL A pl HWA DDDGN P TE Q YP L NPNGS PG G V AGIC SC DGR H L AV MPHPERAV R 1303
Cdd:cd01740 140 G E VL RIPV AHGEG RFYADDET L AELE E NGQI A -- QYV DDDGN V TE R YP A NPNGS LD G I AGIC NE DGR V L GM MPHPERAV E 217
250 260
....*....|....*....|....*..
gi 1370471312 1304 PWQW awrppp FDT L TT S PW L Q LF I NA R 1330
Cdd:cd01740 218 PWQW ------ ERL L GG S DG L K LF R NA V 238
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
707-981
1.05e-77
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 257.46
E-value: 1.05e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 707 D V AV VALSH E ELI G A A TAL GE Q P VK SLLDP KVA A R LAVAEA LT NLV FALVTD L r DVKCSG N WMWAA K LP GE GAA L AD A CE 786
Cdd:cd02204 1 D A AV LRIPG E TDK G L A MST GE N P RY SLLDP YAG A A LAVAEA VR NLV AVGADP L - AITDCL N FGNPE K PE GE MGQ L VE A VL 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 787 AMVAVMA ALG VA V D GGKDSL SMA arvg TE T V RA P GS LVI S A YA V CP D ITAT VT P D L K HP egr G H LLY VALSPGQHRL G GT 866
Cdd:cd02204 80 GLGDACR ALG TP V I GGKDSL YNE ---- TE G V AI P PT LVI G A VG V VD D VRKI VT L D F K KE --- G D LLY LIGETKDELG G SE 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 867 ALAQCFSQL G EH PP DL DL p E NLVRA F SIT Q G L L K DR L LC S G HDVSDGGL VTC L L EMAFAG NC G LQ v DVPVPRVDVLSV LF 946
Cdd:cd02204 153 YALAYHGLG G GA PP LV DL - E REKAL F DAV Q E L I K EG L VL S A HDVSDGGL AVA L A EMAFAG GL G AE - VDLSKDDAEDEL LF 230
250 260 270
....*....|....*....|....*....|....*
gi 1370471312 947 A E EP G L VL EVQE P DLAQ V LK r YRD AG LHCLEL G HT 981
Cdd:cd02204 231 S E SL G R VL VEVK P ENEE V FE - AEE AG VPATVI G TV 264
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
1063-1332
2.13e-77
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 255.37
E-value: 2.13e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1063 P R VAIL REE GSN G DR E MA D AF HL AG F E VW DV TMQ DL csg AIG LD T F R G VAFV GGFSY A D V L GSAKGW A AA vtfhp RAGAE 1142
Cdd:COG0047 1 P K VAIL VFP GSN C DR D MA A AF ER AG A E AE DV WHS DL --- RTD LD D F D G LVLP GGFSY G D Y L RAGAIA A FS ----- PIMDA 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1143 L R R F RK R p DTFS LG V CNG C Q L L AL LG WV ggdpnedaaemg P DSQ PA rpgll L RH N L S G R YES RW ASV RV GPGPALMLR GM 1222
Cdd:COG0047 73 V R E F AR R - GGLV LG I CNG F Q I L TE LG LL ------------ P GIW PA ----- L TR N R S L R FIC RW VYL RV ENNDSPFTS GM 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1223 E - G A V L P VWS AHGEG - YVA fs SP E LQ A QI EA R G LAPLHWA D D DGN P T eq YP L NPNGS PGGV AGI CSC DG RH L AV MPHPER 1300
Cdd:COG0047 135 E a G E V I P IPI AHGEG r YVA -- DE E TL A EL EA N G QVAFRYV D A DGN V T -- YP A NPNGS LNNI AGI TNE DG NV L GM MPHPER 210
250 260 270
....*....|....*....|....*....|..
gi 1370471312 1301 AV R P WQ wawr P P PFD T ltts PW L QL F IN A RNW 1332
Cdd:COG0047 211 AV E P LL ---- G P GES T ---- DG L RI F RS A VKY 234
FGAM_synth_II
TIGR01736 phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ...
304-1013
2.06e-57
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain]
Cd Length: 715
Bit Score: 212.55
E-value: 2.06e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 304 VVF TA E T HN F P TGVC P FS GA T TG T GG RI RD VQCT gr GA HVV A GTAGYC FG N L HI P gynlpwedpsfqypgnfa RPLEVAI 383
Cdd:TIGR01736 71 VVF KM E S HN H P SAIE P YN GA A TG V GG IL RD ILSM -- GA RPI A LLDSLR FG P L DD P ------------------ KNRYLFE 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 384 EASN G A SDYGN KF G E P VLA G --- F AR S L glqlp D G Q rrewik P IMFSGGI G SMEA D H I SK - E A PE PG MEV V K VGG PVY R I 459
Cdd:TIGR01736 131 GVVA G I SDYGN RI G V P TVG G eve F DE S Y ----- N G N ------ P LVNVMCV G LVRK D D I VT g K A KG PG NKL V L VGG KTG R D 199
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 460 G V GG GAAS S VQV q GDNTSDL D FG AVQ R GDP EM E QKM nrv I R A CV EA PKGNPICSLH D Q GA G G NGNVLK E LSDPA -- GA I I 537
Cdd:TIGR01736 200 G I GG ATFA S EEL - SEEAEEE D RP AVQ V GDP FT E KLL --- I E A TL EA VDTGLVKGIK D L GA A G LTSASS E MAAKG gl GA E I 275
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 538 Y TSRFQ L GD P TLNAL EI WGA E Y QE SNA L LLRSPNRDFLTHVSARERC PA CFV G TI T GDR RI V L VDDR E CPV rrngqg D A P 617
Cdd:TIGR01736 276 Y LDKVP L RE P GMTPY EI MLS E S QE RML L VVAPEDVEEVLEIFEKYEL PA SVI G EV T DEG RI R L YYKG E VVA ------ D L P 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 618 PTP L PTPVDL E LEWVLG K M P RK E fflq RK P pmlqplal P P GLSVHQ A LER VL RL P AV ASK RYLTNKV D RS V GG lvaqqqc 697
Cdd:TIGR01736 350 IEL L ADAPEY E RPSEPP K Y P EE E ---- KE P -------- E P PADLED A FLK VL SS P NI ASK EWVYRQY D HE V QT ------- 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 698 v GPLQT P LA D V AV VALSHEELI G A A TALGEQ P VKSL LDP KVA A RL AVAEA LT NL VFALVTD L RD V K C -- S GN ------- W 768
Cdd:TIGR01736 411 - RTVVK P GE D A AV LRIKETGKL G L A LTADCN P RYVY LDP YAG A AG AVAEA YR NL AAVGAEP L AA V D C ln F GN perpevy W 489
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 769 MWAAKLP G egaa L A DAC E amvavma ALG VA V D GG KD SL SMA arvg T ET V RAPGSLV I SAYAVCP D ITATV T PDL K hpe GR 848
Cdd:TIGR01736 490 QFVEAVK G ---- L G DAC R ------- ALG TP V V GG NV SL YNE ---- T NG V PIAPTPT I GMVGLVE D VEKLL T SNF K --- KE 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 849 G HLL Y VA lsp G QHR -- LGG TALAQCFSQLGEH - P P DL DL p E NLVRAFSITQGLLKDR L LCSG HDVS D GGL VTC L L EMA F A 925
Cdd:TIGR01736 552 G DAI Y LI --- G ETK de LGG SEYLRVIHGIVSG q V P AV DL - E EEKELADAVREAIRAG L VSAA HDVS R GGL AVA L A EMA A A 627
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 926 GNC G LQ VD VPVPRVDVLSV - LF A E EP G - LVLE V Q E PDLAQVL K ryr DA G LHCLEL G H TG eagp HAMVRVSVNG a VVLEEP 1003
Cdd:TIGR01736 628 SGI G AE VD IDEIASARPDE l LF S E SN G r AIVA V P E EKAEEAV K --- SK G VPAKVI G K TG ---- GDRLTIKTGD - DTISVS 699
730
....*....|
gi 1370471312 1004 V G ELR AL WEE 1013
Cdd:TIGR01736 700 V K ELR DA WEE 709
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
304-1014
1.72e-50
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 191.86
E-value: 1.72e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 304 VVF TA E T HN F P TG V C P FS GA T TG T GG RI RD VQCT G rg A HVV A GTAGYC FG N L hipgynlpw ED P SFQ Y -- P G nfarpl E V 381
Cdd:PRK01213 83 VVF KI E S HN H P SA V E P YQ GA A TG V GG IL RD IFSM G -- A RPI A LLDSLR FG E L --------- DH P KTR Y ll E G ------ V V 145
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 382 A ieasn G ASD YGN KF G E P VLA G --- F AR S L glqlp D G Q rrewik P IMFSGGI G SMEA D H I SK - E A PEP G ME VV K VG GPVY 457
Cdd:PRK01213 146 A ----- G IGG YGN CI G V P TVG G evy F DE S Y ----- N G N ------ P LVNAMCV G LVRH D D I VL a K A SGV G NP VV Y VG AKTG 209
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 458 R I G V GG GAAS S VQVQGDNTSDL df G AVQ R GDP E ME Q kmn RV I R AC V E AP K GNPICSLH D Q GA G G NGNVLK E LSDPA -- G A 535
Cdd:PRK01213 210 R D G I GG ASFA S AELSEESEEKR -- P AVQ V GDP F ME K --- LL I E AC L E LI K TGLVVGIQ D M GA A G LTCSSS E MAAKG gl G I 284
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 536 IIYTSRFQ L GDPTLNAL EI WGA E Y QE SNA L LLRSPNRD flthv SARERC ----- P A CFV G TI T G D R R IV lvddrecp V RR 610
Cdd:PRK01213 285 ELDLDKVP L REEGMTPY EI MLS E S QE RML L VVKPGKEE ----- EVLAIF ekwdl D A AVI G EV T D D G R LR -------- V YH 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 611 N G Q -- G D A P PTP L -- PT PV d LELEW vlgkmprkefflqr K P P MLQPLALPPGLSVHQ AL ERV L RL P AV ASK RYLTNKV D R 686
Cdd:PRK01213 352 H G E vv A D V P AEA L ad EA PV - YDRPY -------------- K E P AYLDELQADPEDLKE AL LKL L SS P NI ASK EWVYEQY D H 416
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 687 S V GG -- L V A qqqcvgplqt P LA D V AV VAL s HEELI G A A TALGEQ P VKSL LDP KVA A R LAVAEA LT NL V falvtdlrdvk C 764
Cdd:PRK01213 417 E V QT nt V V K ---------- P GG D A AV LRI - RGGGK G L A LTTDCN P RYVY LDP YEG A K LAVAEA AR NL A ----------- A 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 765 S G ---------- N W -------- MW A aklpgegaa LAD A CEAMVAVMA ALG VA V D GG KD SL S maarvg T ET VRAP -- GSL V 824
Cdd:PRK01213 475 V G atplaitdcl N F gnpekpev MW Q --------- FVE A VRGLADACR ALG TP V V GG NV SL Y ------ N ET GGTA iy PTP V 539
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 825 I SAYAVCP D ITATV T PDL K HP egr G H L L Y VA lsp G QHR -- LGG TALAQCF - SQL G EH PP DL DL PE ----- N LVR A f S I TQ 896
Cdd:PRK01213 540 I GMVGLID D VSKRT T SGF K KE --- G D L I Y LL --- G ETK de LGG SEYLKVI h GHV G GR PP KV DL EA ekrlq E LVR E - A I RE 612
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 897 GL LK drllc S G HDVS D GGL VTC L L EMA F AG NC G LQ VD VPVPRVDV l SV LF A E EP G - L V LE V QEPDLAQVLKRYRD AG LHC 975
Cdd:PRK01213 613 GL VT ----- S A HDVS E GGL AVA L A EMA I AG GL G AE VD LSDGLRPD - AL LF S E SQ G r Y V VS V PPENEEAFEALAEA AG VPA 686
730 740 750
....*....|....*....|....*....|....*....
gi 1370471312 976 LEL G HT G EAG pham VR V SV N GAVV LE epvg ELR AL WE ET 1014
Cdd:PRK01213 687 TRI G VV G GDA ---- LK V KG N DTES LE ---- ELR EA WE GA 717
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
303-590
6.08e-40
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 149.37
E-value: 6.08e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 303 HVVFTA E T HN F P TGVC P FS GA T TG T GG R IRD VQC TG RG A HVV A GT A GYCFGNL H IP gynlpwedpsfqypgnfar PLEVA 382
Cdd:cd02193 2 GEAMKI E E HN H P AAID P AA GA A TG V GG A IRD IAA TG ID A KPI A LS A NWMASAG H PG ------------------- EDAIL 62
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 383 IE A SN G ASDYG N KF G E P VLA G FA R SLGL --- Q LPDG QR REWIK P IMFSGGI G SMEA D HISK - EAPEP G MEVVKV GG PVYR 458
Cdd:cd02193 63 YD A VK G VAELC N QL G L P IPV G KD R MSMK trw Q EGNE QR EMTHP P SLVISAF G RVRD D RHTL p QLSTE G NALLLI GG GKGH 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 459 I G V GG G A AS SV QVQGD nts D L DFGAV Q RG DP EM E QKMNRVIR A C V E A pkg NPICSL HD Q GAGG NGNV L K EL SDPA -- G AI 536
Cdd:cd02193 143 N G L GG T A LA SV ALSYR --- Q L GDKSA Q VR DP AQ E KGFYEAMQ A L V A A --- GKLLAW HD R GAGG LLVA L A EL VFAG hc G VQ 216
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1370471312 537 IYTSRFQLGD P TLNA LEI WGA E Y QE SNALLL R SPN RD FLTHVSARERCPACFV G 590
Cdd:cd02193 217 VDLAALGDDE P DMEP LEI ALF E S QE RGVIQV R AED RD AVEEAQYGLADCVHVL G 270
FGAM_synth_I
TIGR01737 phosphoribosylformylglycinamidine synthase I; In some species, ...
1064-1304
5.01e-34
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain]
Cd Length: 227
Bit Score: 130.96
E-value: 5.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1064 R VA IL R EE G S N G DR EMAD A FH L A G FEVWD V TMQ D L csgai G L DTFR GV AFV GGFSY A D V L GSAKGW AA AVTF hprag A E L 1143
Cdd:TIGR01737 2 K VA VI R FP G T N C DR DTVY A LR L L G VDAEI V WYE D G ----- S L PDYD GV VLP GGFSY G D Y L RAGAIA AA SPIM ----- Q E V 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1144 R R F RKR p DTFS LG V CNG C Q L L ALL G wvggdpnedaaemgpdsqp AR PG L LL r H N L S G R YES RW ASV RV GPGPALMLRGM - 1222
Cdd:TIGR01737 72 R E F AEK - GVPV LG I CNG F Q I L VEA G ------------------- LL PG A LL - P N D S L R FIC RW VYL RV ENADTIFTKNY k 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1223 E G A V LPVWS AHGEG YVAFSSPE L q A QI E ARGLAPLHWA D D DG NPT E QY pl NPNGS P G GV AGI CSCD G RH L AV MPHPERA V 1302
Cdd:TIGR01737 131 K G E V IRIPI AHGEG RYYADDET L - A RL E SNDQVVFRYC D E DG DVA E EA -- NPNGS V G NI AGI VNER G NV L GM MPHPERA S 207
..
gi 1370471312 1303 RP 1304
Cdd:TIGR01737 208 EK 209
PRK01175
PRK01175 phosphoribosylformylglycinamidine synthase I; Provisional
1062-1306
9.19e-34
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain]
Cd Length: 261
Bit Score: 131.42
E-value: 9.19e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1062 S P RVA I LR E EG S N GDR E MAD AF HLA G F E VWD V TMQ DL CSGAIGLDTFRGVAFV GGFS YA D VLGSAKGW AA AVT fh PRAGA 1141
Cdd:PRK01175 3 S I RVA V LR M EG T N CED E TVK AF RRL G V E PEY V HIN DL AAERKSVSDYDCLVIP GGFS AG D YIRAGAIF AA RLK -- AVLRK 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1142 ELRR F RKR p DTFSL G V CNG C Q L L AL LG wvggdpneda AEM G P D SQPAR P GLL L RH N L S G R Y E S R WASVRVGPGPALMLRG 1221
Cdd:PRK01175 81 DIEE F IDE - GYPII G I CNG F Q V L VE LG ---------- LLP G F D EIAEK P EMA L TV N E S N R F E C R PTYLKKENRKCIFTKL 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1222 MEGA V LP V WS AH G EG Y V A FS SP E LQAQIEARGLAPLHWA D DD GN p TEQ YP L NPNGS PGGV AGI CSCD G RHLAV MPHPERA 1301
Cdd:PRK01175 150 LKKD V FQ V PV AH A EG R V V FS EE E ILERLIENDQIVFRYV D EN GN - YAG YP W NPNGS IYNI AGI TNEK G NVIGL MPHPERA 228
....*
gi 1370471312 1302 VRPW Q 1306
Cdd:PRK01175 229 FYGY Q 233
PRK03619
PRK03619 phosphoribosylformylglycinamidine synthase subunit PurQ;
1064-1304
1.26e-26
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain]
Cd Length: 219
Bit Score: 109.43
E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1064 R VA ILREE GSN G DR E MA D A F - H L A G F E --- VW dvtmqdlc SGAIG LD TFRG V AFV GGFSY A D V L gsakgwaaavtfhp R A 1139
Cdd:PRK03619 2 K VA VIVFP GSN C DR D MA R A L r D L L G A E pey VW -------- HKETD LD GVDA V VLP GGFSY G D Y L -------------- R C 59
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1140 GA --------- ELRR F RKR p DTFS LG V CNG C Q L L A --- LL gwvggdpnedaaemgpdsqpar PG L L L R h N L S GRYES R WA 1207
Cdd:PRK03619 60 GA iaafspimk AVKE F AEK - GKPV LG I CNG F Q I L T eag LL ---------------------- PG A L T R - N A S LKFIC R DV 115
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1208 SV RV GPGPALMLR G M E - G A V L -- P V ws AHGEG - Y V A fs SP E LQAQI E AR G LAPLHWA D D dgnpteqypl NPNGS PGGV AG 1283
Cdd:PRK03619 116 HL RV ENNDTPFTS G Y E k G E V I ri P I -- AHGEG n Y Y A -- DE E TLKRL E GN G QVVFRYC D E ---------- NPNGS VNDI AG 181
250 260
....*....|....*....|.
gi 1370471312 1284 I CSCD G RH L AV MPHPERAV R P 1304
Cdd:PRK03619 182 I VNEK G NV L GM MPHPERAV E P 202
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
444-602
9.51e-26
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 104.35
E-value: 9.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 444 E PG MEVVKV G G pvyr I G VG G GAA S SVQVQGDNTSD ldf G AVQ R GDP EM E QKMNR V IRACVEA pk G NPICSL HD QGA GG NG 523
Cdd:pfam02769 1 K PG DVLILL G S ---- S G LH G AGL S LSRKGLEDSGL --- A AVQ L GDP LL E PTLIY V KLLLAAL -- G GLVKAM HD ITG GG LA 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 524 NV L K E LSDPA -- GA I I YTSRFQLGDPTLNA LE IWGA E Y Q ESNALLLRSPNRDFLTHVSAR E RCP A CFV G TI T GDR R IVLV 601
Cdd:pfam02769 72 GA L A E MAPAS gv GA E I DLDKVPIFEELMLP LE MLLS E N Q GRGLVVVAPEEAEAVLAILEK E GLE A AVI G EV T AGG R LTVI 151
.
gi 1370471312 602 D 602
Cdd:pfam02769 152 V 152
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
720-972
2.45e-23
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 101.22
E-value: 2.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 720 G A A TALG E QPVKSLL DP KVA A RLA V AE A LTN l VF A LVT D LRDVKC S G NWM WA A KL PGE G A A L A DA CEAMVAVMAA LG VAV 799
Cdd:cd02193 2 G E A MKIE E HNHPAAI DP AAG A ATG V GG A IRD - IA A TGI D AKPIAL S A NWM AS A GH PGE D A I L Y DA VKGVAELCNQ LG LPI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 800 DG GKD SL SM AA R -- V G T E TVRA -- P G SLVISA YAVCP D ITA T ---- V T PDLK hpegrgh LL YVALSP G QHR LGGTALA Q - 870
Cdd:cd02193 81 PV GKD RM SM KT R wq E G N E QREM th P P SLVISA FGRVR D DRH T lpql S T EGNA ------- LL LIGGGK G HNG LGGTALA S v 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 871 -- CFS QLG EHPPDLDL P ENLVRAFSIT Q G L LKDRL L CSG HD VSD GGL VTC L L E MA FAG N CG L Q ------ V D VPVPRVDVL 942
Cdd:cd02193 154 al SYR QLG DKSAQVRD P AQEKGFYEAM Q A L VAAGK L LAW HD RGA GGL LVA L A E LV FAG H CG V Q vdlaal G D DEPDMEPLE 233
250 260 270
....*....|....*....|....*....|...
gi 1370471312 943 SV LF AEEPGL V LE V QEP D LAQ V L --- KRYR D AG 972
Cdd:cd02193 234 IA LF ESQERG V IQ V RAE D RDA V E eaq YGLA D CV 266
PRK14090
PRK14090 phosphoribosylformylglycinamidine synthase subunit PurL;
304-566
2.35e-16
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain]
Cd Length: 601
Bit Score: 84.14
E-value: 2.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 304 VV F TA E T HN F P TGVC P FS GA T TG T GG R IRDV qc TGR GA HVV A gtagy C F GN LH I pgynlpwedpsfqypgnf A R PLEVA I 383
Cdd:PRK14090 63 IA F KI E S HN H P SAIE P YN GA A TG V GG I IRDV -- LAM GA RPT A ----- I F DS LH M ------------------ S R IIDGI I 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 384 E asn G AS DYGN KF G E P VLA G farsl G L QLPDGQRREWIKPIM f SG G IGSME a DHISKE A PE PG MEV V KV GG PVY R I G VG G 463
Cdd:PRK14090 118 E --- G IA DYGN SI G V P TVG G ----- E L RISSLYAHNPLVNVL - AA G VVRND - MLVDSK A SR PG QVI V IF GG ATG R D G IH G 187
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 464 GAAS S VQVQ G DNTSD L dfg AV Q R GDP EM E QKM nrv I R A CV E APKGNPICSLH D Q GAGG NGNVLK EL SDPA -- GAI IYTS R 541
Cdd:PRK14090 188 ASFA S EDLT G EKATK L --- SI Q V GDP FA E KML --- I E A FL E MVEEGLVEGAQ D L GAGG VLSATS EL VAKG gl GAI VHLD R 261
250 260
....*....|....*....|....*
gi 1370471312 542 FQ L GD P TLNAL EI WGA E Y QE SN A LL 566
Cdd:PRK14090 262 VP L RE P DMEPW EI LIS E S QE RM A VV 286
FGAR-AT_N
pfam18076 Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain ...
46-151
2.39e-15
Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide and glutamine to formylglycinamidine ribonucleotide, ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway.
Pssm-ID: 465635 [Multi-domain]
Cd Length: 115
Bit Score: 73.27
E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 46 WTAEA L p SA E E TKK L MW L fgcpll L D dv ARESWLL P GSNDL LL E V G PRL NFST P T S --- T N I VSV C rat GL GP V D R V E TT 122
Cdd:pfam18076 7 ELEAP L - SA A E RAR L EQ L ------ L T -- YGPPLEE P EPEGE LL L V T PRL GTIS P W S ska T D I AHN C --- GL DA V R R I E RG 74
90 100
....*....|....*....|....*....
gi 1370471312 123 RR Y R L SFAHPPS AE VE A I A l A T LHDRMTE 151
Cdd:pfam18076 75 IA Y Y L TGKPLSA AE LA A L A - A L LHDRMTE 102
FGAR-AT_linker
pfam18072 Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ...
184-232
5.99e-10
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain]
Cd Length: 50
Bit Score: 55.94
E-value: 5.99e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1370471312 184 LE K AN QE LGLAL DSWDL D FYTKR F QE L Q RNP ST VE AFDL AQ SN SEH S RH 232
Cdd:pfam18072 1 LE E AN RY LGLAL SDDEI D YLVEY F AG L G RNP TD VE LGMF AQ MW SEH C RH 49
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
899-985
1.27e-07
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 52.35
E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 899 LKDR L LCSG HD VSD GGL VTC L L EMA F A GNC G LQ ----- V DVPVPRVDV L SV L FA E EP G - LVLE V QEPDLAQ VL KRYRDA G 972
Cdd:pfam02769 54 ALGG L VKAM HD ITG GGL AGA L A EMA P A SGV G AE idldk V PIFEELMLP L EM L LS E NQ G r GLVV V APEEAEA VL AILEKE G 133
90
....*....|...
gi 1370471312 973 L HCLEL G HTGEA G 985
Cdd:pfam02769 134 L EAAVI G EVTAG G 146
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
722-979
3.32e-05
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 46.62
E-value: 3.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 722 A TALGEQPVKSLLD P KVAA RLAV AE A LTNLV fal VTDL R DVKCSGNWMWAA kl PG E GAA L A D ACEAMVAVMAA LGV AVD G 801
Cdd:cd00396 3 A MSTDGINPPLAIN P WAGG RLAV GG A VNDIA --- AMGA R PIALLASLSLSN -- GL E VDI L E D VVDGVAEACNQ LGV PIV G 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 802 G KD S L S M aarvgt E T VRAPG SL VIS A YA V CPDITAT vtpdlkhpegrghllyvalspgqhrlggtalaqcfsqlgeh PPD 881
Cdd:cd00396 78 G HT S V S P ------ G T MGHKL SL AVF A IG V VEKDRVI ----------------------------------------- DSS 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 882 LDL P ENLVRAFSI -- TQG L LKDRLLCSG HD VS DGGL VTC L L E M A F A GNC G LQ ----------- V DVPVPRVDVLSV LF AE 948
Cdd:cd00396 111 GAR P GDVLILTGV da VLE L VAAGDVHAM HD IT DGGL LGT L P E L A Q A SGV G AE idleaipldev V RWLCVEHIEEAL LF NS 190
250 260 270
....*....|....*....|....*....|.
gi 1370471312 949 EP GL VLE V QEPDLAQ VL KRYRDA G LHCLEL G 979
Cdd:cd00396 191 SG GL LIA V PAEEADA VL LLLNGN G IDAAVI G 221
GATase1
cd01653 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1065-1166
4.29e-05
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group includes proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA. and, the A4 beta-galactosidase middle domain. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Pssm-ID: 153210 [Multi-domain]
Cd Length: 115
Bit Score: 44.13
E-value: 4.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1065 VA I L REE G SNGD -- REMA DA FHL AG F EV WD V TMQ - DLCSGAIG LD TFR G VAFV GG FSYA D V L gsakgwaaav TFHPRAG A 1141
Cdd:cd01653 1 VA V L LFP G FEEL el ASPL DA LRE AG A EV DV V SPD g GPVESDVD LD DYD G LILP GG PGTP D D L ---------- ARDEALL A 70
90 100
....*....|....*....|....*
gi 1370471312 1142 E LR RFRKR p DTFS LG V C N G C QLL A L 1166
Cdd:cd01653 71 L LR EAAAA - GKPI LG I C L G A QLL V L 94
GAT_1
cd03128 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1065-1164
2.29e-04
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA, the A4 beta-galactosidase middle domain and peptidase E. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase (CPSase), cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad of typical GATase1 domains, by having a Ser in place of the reactive Cys at the nucleophile elbow. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase. Peptidase E has a circular permutation in the common core of a typical GTAse1 domain.
Pssm-ID: 153222 [Multi-domain]
Cd Length: 92
Bit Score: 41.42
E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471312 1065 VA I L REE GS NGD -- REMA DA FHL AG F EV WD V TMQ - DLCSGAIG LD TFR G VAFV GG FSYA D V L gsakgwaaav TFHPRAG A 1141
Cdd:cd03128 1 VA V L LFG GS EEL el ASPL DA LRE AG A EV DV V SPD g GPVESDVD LD DYD G LILP GG PGTP D D L ---------- AWDEALL A 70
90 100
....*....|....*....|...
gi 1370471312 1142 E LR RFRKR p DTFS LG V C N G C QLL 1164
Cdd:cd03128 71 L LR EAAAA - GKPV LG I C L G A QLL 92
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
