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Conserved domains on  [gi|1370469004|ref|XP_024306159|]
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matrix metalloproteinase-25 isoform X1 [Homo sapiens]

Protein Classification

ZnMc_MMP and HX domain-containing protein( domain architecture ID 10136642)

ZnMc_MMP and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 81-246 6.51e-81

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


:

Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 249.43  E-value: 6.51e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  81 WKKRTLTWRVRSFPQSsqLSQETVRVLMSYALMAWGMESGLTFHEVDSpqGQEPDILIDFARAFHQDSYPFDGLGGTLAH 160
Cdd:cd04278     2 WSKTNLTYRILNYPPD--LPRDDVRRAIARAFRVWSDVTPLTFREVTS--GQEADIRISFARGNHGDGYPFDGPGGTLAH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 161 AFFPGEhpISGDTHFDDEETWTFGSkDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDG 240
Cdd:cd04278    78 AFFPGG--IGGDIHFDDDEQWTLGS-DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRG 151


                  ....*.
gi 1370469004 241 LQQLYG 246
Cdd:cd04278   152 IQALYG 157
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 280-474 6.04e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 188.29  E-value: 6.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 280 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 358
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 359 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 435
Cdd:cd00094    76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370469004 436 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 474
Cdd:cd00094   156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
 
Name Accession Description Interval E-value
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 81-246 6.51e-81

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 249.43  E-value: 6.51e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  81 WKKRTLTWRVRSFPQSsqLSQETVRVLMSYALMAWGMESGLTFHEVDSpqGQEPDILIDFARAFHQDSYPFDGLGGTLAH 160
Cdd:cd04278     2 WSKTNLTYRILNYPPD--LPRDDVRRAIARAFRVWSDVTPLTFREVTS--GQEADIRISFARGNHGDGYPFDGPGGTLAH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 161 AFFPGEhpISGDTHFDDEETWTFGSkDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDG 240
Cdd:cd04278    78 AFFPGG--IGGDIHFDDDEQWTLGS-DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRG 151


                  ....*.
gi 1370469004 241 LQQLYG 246
Cdd:cd04278   152 IQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 81-246 1.63e-73

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 230.20  E-value: 1.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  81 WKKRTLTWRVrsFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPqgqEPDILIDFARAFHQDSYPFDGLGGTLAH 160
Cdd:pfam00413   2 WRKKNLTYRI--LNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTG---EADIMIGFGRGDHGDGYPFDGPGGVLAH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 161 AFFPGEHpISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGpvGDPDKYRLSQDDRDG 240
Cdd:pfam00413  77 AFFPGPG-LGGDIHFDDDETWTVGSDPPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSP--LDSKKFRLSQDDIKG 153


                  ....*.
gi 1370469004 241 LQQLYG 246
Cdd:pfam00413 154 IQQLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 280-474 6.04e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 188.29  E-value: 6.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 280 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 358
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 359 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 435
Cdd:cd00094    76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370469004 436 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 474
Cdd:cd00094   156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 81-247 2.25e-25

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 101.27  E-value: 2.25e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004   81 WKKRTLTWRVrsfpQSSQLSQEtVRVLMSYALMAWGMESGLTFHEVDSpqgqEPDILIDFARAFHqdsypfdglGGTLAH 160
Cdd:smart00235   5 WPKGTVPYVI----DSSSLSPE-EREAIAKALAEWSDVTCIRFVERTG----TADIYISFGSGDS---------GCTLSH 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  161 AFFPGehpisGDTHFDDEeTWTFGskdgegtdlFAVAVHEFGHALGLGHSSAPNS---IMRPFYQGPvgDPDKYRLSQDD 237
Cdd:smart00235  67 AGRPG-----GDQHLSLG-NGCIN---------TGVAAHELGHALGLYHEQSRSDrdnYMYINYTNI--DTRNFDLSEDD 129

                          170
                   ....*....|
gi 1370469004  238 RDGLQQLYGK 247
Cdd:smart00235 130 SLGIPYDYGS 139
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 382-428 3.05e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 52.63  E-value: 3.05e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1370469004  382 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLS-LWEGAPP 428
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISsFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 382-428 3.36e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 52.57  E-value: 3.36e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1370469004 382 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLSLWEGAPP 428
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 190-245 1.28e-06

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 49.68  E-value: 1.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370469004 190 GTDLFAVAVHEFGHALGL-GHSSAPNSIMrpFYQGpVGDPdkYRLSQDDRDGLQQLY 245
Cdd:COG5549   179 GKYLLATARHELGHALGIwGHSPSPTDAM--YFSQ-VRNP--PPISPRDINTLKRIY 230
 
Name Accession Description Interval E-value
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 81-246 6.51e-81

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 249.43  E-value: 6.51e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  81 WKKRTLTWRVRSFPQSsqLSQETVRVLMSYALMAWGMESGLTFHEVDSpqGQEPDILIDFARAFHQDSYPFDGLGGTLAH 160
Cdd:cd04278     2 WSKTNLTYRILNYPPD--LPRDDVRRAIARAFRVWSDVTPLTFREVTS--GQEADIRISFARGNHGDGYPFDGPGGTLAH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 161 AFFPGEhpISGDTHFDDEETWTFGSkDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDG 240
Cdd:cd04278    78 AFFPGG--IGGDIHFDDDEQWTLGS-DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRG 151


                  ....*.
gi 1370469004 241 LQQLYG 246
Cdd:cd04278   152 IQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 81-246 1.63e-73

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 230.20  E-value: 1.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  81 WKKRTLTWRVrsFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPqgqEPDILIDFARAFHQDSYPFDGLGGTLAH 160
Cdd:pfam00413   2 WRKKNLTYRI--LNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTG---EADIMIGFGRGDHGDGYPFDGPGGVLAH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 161 AFFPGEHpISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGpvGDPDKYRLSQDDRDG 240
Cdd:pfam00413  77 AFFPGPG-LGGDIHFDDDETWTVGSDPPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSP--LDSKKFRLSQDDIKG 153


                  ....*.
gi 1370469004 241 LQQLYG 246
Cdd:pfam00413 154 IQQLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 280-474 6.04e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 188.29  E-value: 6.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 280 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 358
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 359 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 435
Cdd:cd00094    76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370469004 436 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 474
Cdd:cd00094   156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 81-247 2.25e-25

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 101.27  E-value: 2.25e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004   81 WKKRTLTWRVrsfpQSSQLSQEtVRVLMSYALMAWGMESGLTFHEVDSpqgqEPDILIDFARAFHqdsypfdglGGTLAH 160
Cdd:smart00235   5 WPKGTVPYVI----DSSSLSPE-EREAIAKALAEWSDVTCIRFVERTG----TADIYISFGSGDS---------GCTLSH 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  161 AFFPGehpisGDTHFDDEeTWTFGskdgegtdlFAVAVHEFGHALGLGHSSAPNS---IMRPFYQGPvgDPDKYRLSQDD 237
Cdd:smart00235  67 AGRPG-----GDQHLSLG-NGCIN---------TGVAAHELGHALGLYHEQSRSDrdnYMYINYTNI--DTRNFDLSEDD 129

                          170
                   ....*....|
gi 1370469004  238 RDGLQQLYGK 247
Cdd:smart00235 130 SLGIPYDYGS 139
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 83-246 2.64e-15

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 73.26  E-value: 2.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  83 KRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFheVDSP-QGQEPDILIdfaraFHQDSYPFDGLGGTLAHA 161
Cdd:cd04279     1 KSPIRVYIDPTPAPPDSRAQSWLQAVKQAAAEWENVGPLKF--VYNPeEDNDADIVI-----FFDRPPPVGGAGGGLARA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 162 FFPGEHPISGDT--HFDDEETWTFGSKDgegTDLFAVAVHEFGHALGLGHSSA-PNSIMRPFY-QGPVGDPdkyRLSQDD 237
Cdd:cd04279    74 GFPLISDGNRKLfnRTDINLGPGQPRGA---ENLQAIALHELGHALGLWHHSDrPEDAMYPSQgQGPDGNP---TLSARD 147


                  ....*....
gi 1370469004 238 RDGLQQLYG 246
Cdd:cd04279   148 VATLKRLYG 156
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 95-245 9.75e-15

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 72.17  E-value: 9.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  95 QSSQLSQETVRVLMSYALMAWGMESGLTFHEVDsPQGQEPDILIDFARAfhqdsypfDGLGGTLAHAFFPG-EHPISGDT 173
Cdd:cd00203    14 VEEENLSAQIQSLILIAMQIWRDYLNIRFVLVG-VEIDKADIAILVTRQ--------DFDGGTGGWAYLGRvCDSLRGVG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 174 HFDDEETWTFgskdgegtDLFAVAVHEFGHALGLGHSS--------------------APNSIMRPFYqGPVGDPDKYRL 233
Cdd:cd00203    85 VLQDNQSGTK--------EGAQTIAHELGHALGFYHDHdrkdrddyptiddtlnaeddDYYSVMSYTK-GSFSDGQRKDF 155

                         170
                  ....*....|..
gi 1370469004 234 SQDDRDGLQQLY 245
Cdd:cd00203   156 SQCDIDQINKLY 167
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 74-246 8.31e-13

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 67.06  E-value: 8.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  74 YALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVlMSYALMAWGMESGLTFHEVDSPQGqePDIlidfarAFHQDSypfDG 153
Cdd:cd04277     6 YSFSNTGGPYSYGYGREEDTTNTAALSAAQQAA-ARDALEAWEDVADIDFVEVSDNSG--ADI------RFGNSS---DP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 154 LGGTLAHAFFPG---EHPISGDTHFDDEETWTFGSKdgeGTDLFAVAVHEFGHALGLGHS----------------SAPN 214
Cdd:cd04277    74 DGNTAGYAYYPGsgsGTAYGGDIWFNSSYDTNSDSP---GSYGYQTIIHEIGHALGLEHPgdynggdpvpptyaldSREY 150

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370469004 215 SIMRpfYQGPVGDPD--KYRLSQ----DDRDGLQQLYG 246
Cdd:cd04277   151 TVMS--YNSGYGNGAsaGGGYPQtpmlLDIAALQYLYG 186
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 83-245 4.00e-10

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 58.66  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004  83 KRTLTWRV-RSFPqssqlsqETVRVLMSYALMAWGMESGLTFheVDSPQGQEPDILIDFARAFHQDsypfDGLGGTLAHA 161
Cdd:cd04268     1 KKPITYYIdDSVP-------DKLRAAILDAIEAWNKAFAIGF--KNANDVDPADIRYSVIRWIPYN----DGTWSYGPSQ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 162 FFPGEHPISgdthfDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSA----------------PNSIM---RPFYQ 222
Cdd:cd04268    68 VDPLTGEIL-----LARVYLYSSFVEYSGARLRNTAEHELGHALGLRHNFAasdrddnvdllaekgdTSSVMdyaPSNFS 142

                         170       180
                  ....*....|....*....|...
gi 1370469004 223 GPVGDPDKYRLSQDDRDGLQQLY 245
Cdd:cd04268   143 IQLGDGQKYTIGPYDIAAIKKLY 165
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 382-428 3.05e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 52.63  E-value: 3.05e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1370469004  382 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLS-LWEGAPP 428
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISsFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 382-428 3.36e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 52.57  E-value: 3.36e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1370469004 382 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLSLWEGAPP 428
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 190-245 1.28e-06

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 49.68  E-value: 1.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370469004 190 GTDLFAVAVHEFGHALGL-GHSSAPNSIMrpFYQGpVGDPdkYRLSQDDRDGLQQLY 245
Cdd:COG5549   179 GKYLLATARHELGHALGIwGHSPSPTDAM--YFSQ-VRNP--PPISPRDINTLKRIY 230
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 287-330 5.72e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.39  E-value: 5.72e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1370469004  287 FDAIA-NIRGETFFFKGPWFWRLQPsGQLVSPRPARLHRFWEGLP 330
Cdd:smart00120   1 IDAAFeLRDGKTYFFKGDKYWRFDP-KRVDPGYPKLISSFFPGLP 44
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
 114-209 1.58e-05

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 45.83  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469004 114 AWGMESGLTFHEVDSPqgqEPDILIDFarafhqdsYPFDG---LGGTLAHAFFPgehpisgdthfdDEETWTFGSKDGEG 190
Cdd:cd04327    31 EWLPYANLKFKFVTDA---DADIRISF--------TPGDGywsYVGTDALLIGA------------DAPTMNLGWFTDDT 87

                          90       100
                  ....*....|....*....|.
gi 1370469004 191 TDLF--AVAVHEFGHALGLGH 209
Cdd:cd04327    88 PDPEfsRVVLHEFGHALGFIH 108
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 287-330 1.05e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.78  E-value: 1.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370469004 287 FDAIANIR-GETFFFKGPWFWRLQPsGQLVSPRPARLHRFWeGLP 330
Cdd:pfam00045   1 IDAAFEDRdGKTYFFKGRKYWRFDP-QRVEPGYPKLISDFP-GLP 43
COG1913 COG1913
Predicted Zn-dependent protease [General function prediction only];
193-219 1.32e-03

Predicted Zn-dependent protease [General function prediction only];


Pssm-ID: 441517  Cd Length: 175  Bit Score: 39.94  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*..
gi 1370469004 193 LFAVAVHEFGHALGLGHSSAPNSIMRP 219
Cdd:COG1913   123 VLKEAVHELGHLFGLGHCPNPRCVMHF 149
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 431-452 3.63e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 35.23  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|..
gi 1370469004 431 DDVTVSNAGDTYFFKGAHYWRF 452
Cdd:pfam00045   2 DAAFEDRDGKTYFFKGRKYWRF 23
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 336-378 7.67e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.46  E-value: 7.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370469004 336 VQAAYaRHRDGRILLFSGPQFWVFQDRQLE-GGARPLTEL-GLPP 378
Cdd:pfam00045   1 IDAAF-EDRDGKTYFFKGRKYWRFDPQRVEpGYPKLISDFpGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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