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Conserved domains on  [gi|1370469002|ref|XP_024306158|]
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matrix metalloproteinase-25 isoform X2 [Homo sapiens]

Protein Classification

PG_binding_1 and HX domain-containing protein( domain architecture ID 10478050)

protein containing domains PG_binding_1, ZnMc, and HX

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 171-365 3.39e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 186.36  E-value: 3.39e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002 171 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 249
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002 250 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 326
Cdd:cd00094    76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370469002 327 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 365
Cdd:cd00094   156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc super family cl00064
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 78-137 2.39e-28

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


The actual alignment was detected with superfamily member cd04278:

Pssm-ID: 469599 [Multi-domain]  Cd Length: 157  Bit Score: 109.22  E-value: 2.39e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002  78 DGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDGLQQLYG 137
Cdd:cd04278   101 DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRGIQALYG 157
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 25-80 9.42e-07

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


:

Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 45.58  E-value: 9.42e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370469002  25 SAQDVSLGVDWLTRYGYLPPPhpaqAQLQSPEKLRDAIKVMQRFAGLPETGRMDGE 80
Cdd:pfam01471   1 SGEDVKELQRYLNRLGYYPGP----VDGYFGPSTEAAVKAFQRAFGLPVDGIVDPE 52
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 171-365 3.39e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 186.36  E-value: 3.39e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002 171 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 249
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002 250 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 326
Cdd:cd00094    76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370469002 327 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 365
Cdd:cd00094   156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 78-137 2.39e-28

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 109.22  E-value: 2.39e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002  78 DGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDGLQQLYG 137
Cdd:cd04278   101 DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRGIQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 74-137 1.67e-26

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 104.24  E-value: 1.67e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370469002  74 TGRMDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGpvGDPDKYRLSQDDRDGLQQLYG 137
Cdd:pfam00413  98 VGSDPPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSP--LDSKKFRLSQDDIKGIQQLYG 159
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 78-138 3.88e-12

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 63.52  E-value: 3.88e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370469002   78 DGEGTDLFAVAVHEFGHALGLGHSSAPNS---IMRPFYQGPvgDPDKYRLSQDDRDGLQQLYGK 138
Cdd:smart00235  78 LGNGCINTGVAAHELGHALGLYHEQSRSDrdnYMYINYTNI--DTRNFDLSEDDSLGIPYDYGS 139
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 273-319 3.94e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.86  E-value: 3.94e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1370469002  273 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLS-LWEGAPP 319
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISsFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 273-319 4.39e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 51.80  E-value: 4.39e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1370469002 273 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLSLWEGAPP 319
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 25-80 9.42e-07

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 45.58  E-value: 9.42e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370469002  25 SAQDVSLGVDWLTRYGYLPPPhpaqAQLQSPEKLRDAIKVMQRFAGLPETGRMDGE 80
Cdd:pfam01471   1 SGEDVKELQRYLNRLGYYPGP----VDGYFGPSTEAAVKAFQRAFGLPVDGIVDPE 52
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 81-136 2.08e-06

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 48.53  E-value: 2.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370469002  81 GTDLFAVAVHEFGHALGL-GHSSAPNSIMrpFYQGpVGDPdkYRLSQDDRDGLQQLY 136
Cdd:COG5549   179 GKYLLATARHELGHALGIwGHSPSPTDAM--YFSQ-VRNP--PPISPRDINTLKRIY 230
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 171-365 3.39e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 186.36  E-value: 3.39e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002 171 PDRCEG-NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPArlHRFWEGLPAQVrvvQAAYARHRDGRILLFSGPQFWV 249
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLI--SSFWPSLPSPV---DAAFERPDTGKIYFFKGDKYWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002 250 FQDRQLE-GGARPLTELGLPPGEE-VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLS-LWEGAPPSPDDVTV 326
Cdd:cd00094    76 YTGKNLEpGYPKPISDLGFPPTVKqIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIEtDFPGVPDKVDAAFR 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370469002 327 SNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 365
Cdd:cd00094   156 WLDGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 78-137 2.39e-28

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 109.22  E-value: 2.39e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002  78 DGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGdpdKYRLSQDDRDGLQQLYG 137
Cdd:cd04278   101 DSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP---KFKLSQDDIRGIQALYG 157
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 74-137 1.67e-26

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 104.24  E-value: 1.67e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370469002  74 TGRMDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGpvGDPDKYRLSQDDRDGLQQLYG 137
Cdd:pfam00413  98 VGSDPPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSP--LDSKKFRLSQDDIKGIQQLYG 159
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 78-138 3.88e-12

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 63.52  E-value: 3.88e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370469002   78 DGEGTDLFAVAVHEFGHALGLGHSSAPNS---IMRPFYQGPvgDPDKYRLSQDDRDGLQQLYGK 138
Cdd:smart00235  78 LGNGCINTGVAAHELGHALGLYHEQSRSDrdnYMYINYTNI--DTRNFDLSEDDSLGIPYDYGS 139
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 81-137 1.20e-11

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 62.47  E-value: 1.20e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370469002  81 GTDLFAVAVHEFGHALGLGHSSA-PNSIMRPFY-QGPVGDPdkyRLSQDDRDGLQQLYG 137
Cdd:cd04279   101 AENLQAIALHELGHALGLWHHSDrPEDAMYPSQgQGPDGNP---TLSARDVATLKRLYG 156
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 273-319 3.94e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.86  E-value: 3.94e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1370469002  273 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLS-LWEGAPP 319
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISsFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 273-319 4.39e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 51.80  E-value: 4.39e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1370469002 273 VDAVFSWPqNGKTYLVRGRQYWRYDEaaARPDPGYPRDLSLWEGAPP 319
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDP--QRVEPGYPKLISDFPGLPC 44
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 73-136 7.02e-09

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 54.81  E-value: 7.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002  73 ETGRMDGEGTDLFAVAVHEFGHALGLGHSSA----------------PNSIM---RPFYQGPVGDPDKYRLSQDDRDGLQ 133
Cdd:cd04268    83 YSSFVEYSGARLRNTAEHELGHALGLRHNFAasdrddnvdllaekgdTSSVMdyaPSNFSIQLGDGQKYTIGPYDIAAIK 162


                  ...
gi 1370469002 134 QLY 136
Cdd:cd04268   163 KLY 165
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 83-136 2.86e-07

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 50.21  E-value: 2.86e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370469002  83 DLFAVAVHEFGHALGLGHSS--------------------APNSIMRPFYqGPVGDPDKYRLSQDDRDGLQQLY 136
Cdd:cd00203    95 EGAQTIAHELGHALGFYHDHdrkdrddyptiddtlnaeddDYYSVMSYTK-GSFSDGQRKDFSQCDIDQINKLY 167
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 25-80 9.42e-07

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 45.58  E-value: 9.42e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370469002  25 SAQDVSLGVDWLTRYGYLPPPhpaqAQLQSPEKLRDAIKVMQRFAGLPETGRMDGE 80
Cdd:pfam01471   1 SGEDVKELQRYLNRLGYYPGP----VDGYFGPSTEAAVKAFQRAFGLPVDGIVDPE 52
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 81-136 2.08e-06

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 48.53  E-value: 2.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370469002  81 GTDLFAVAVHEFGHALGL-GHSSAPNSIMrpFYQGpVGDPdkYRLSQDDRDGLQQLY 136
Cdd:COG5549   179 GKYLLATARHELGHALGIwGHSPSPTDAM--YFSQ-VRNP--PPISPRDINTLKRIY 230
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 178-221 6.58e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 6.58e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1370469002  178 FDAIA-NIRGETFFFKGPWFWRLQPsGQLVSPRPARLHRFWEGLP 221
Cdd:smart00120   1 IDAAFeLRDGKTYFFKGDKYWRFDP-KRVDPGYPKLISSFFPGLP 44
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 78-137 1.07e-04

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 42.79  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370469002  78 DGEGTDLFAVAVHEFGHALGLGHS----------------SAPNSIMRpfYQGPVGDPD--KYRLSQ----DDRDGLQQL 135
Cdd:cd04277   107 DSPGSYGYQTIIHEIGHALGLEHPgdynggdpvpptyaldSREYTVMS--YNSGYGNGAsaGGGYPQtpmlLDIAALQYL 184


                  ..
gi 1370469002 136 YG 137
Cdd:cd04277   185 YG 186
COG1913 COG1913
Predicted Zn-dependent protease [General function prediction only];
84-110 9.91e-04

Predicted Zn-dependent protease [General function prediction only];


Pssm-ID: 441517  Cd Length: 175  Bit Score: 39.94  E-value: 9.91e-04
                          10        20
                  ....*....|....*....|....*..
gi 1370469002  84 LFAVAVHEFGHALGLGHSSAPNSIMRP 110
Cdd:COG1913   123 VLKEAVHELGHLFGLGHCPNPRCVMHF 149
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 178-221 1.29e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.39  E-value: 1.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370469002 178 FDAIANIR-GETFFFKGPWFWRLQPsGQLVSPRPARLHRFWeGLP 221
Cdd:pfam00045   1 IDAAFEDRdGKTYFFKGRKYWRFDP-QRVEPGYPKLISDFP-GLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 322-343 3.75e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 35.23  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|..
gi 1370469002 322 DDVTVSNAGDTYFFKGAHYWRF 343
Cdd:pfam00045   2 DAAFEDRDGKTYFFKGRKYWRF 23
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 75-100 6.77e-03

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 37.65  E-value: 6.77e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1370469002  75 GRMDGE-------GTDLFAVAVHEFGHALGLGH 100
Cdd:pfam01400  64 GRVGGRqpvsigdGCDKFGIIVHELGHALGFFH 96
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 227-269 9.11e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.08  E-value: 9.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370469002 227 VQAAYaRHRDGRILLFSGPQFWVFQDRQLE-GGARPLTEL-GLPP 269
Cdd:pfam00045   1 IDAAF-EDRDGKTYFFKGRKYWRFDPQRVEpGYPKLISDFpGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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