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Conserved domains on  [gi|1370468428|ref|XP_024306031|]
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integrin alpha-X isoform X2 [Homo sapiens]

Protein Classification

Int_alpha and Integrin_alpha domain-containing protein( domain architecture ID 12192598)

protein containing domains Int_alpha, Integrin_alpha2, and Integrin_alpha

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 266-682 1.01e-31

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 129.36  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 266 RPVLWVGVSMQFIPAEIPRSAFECREQVVSeQTLVQSNICLYID-KRSKNllGSRDLQSSVTLDLALDPGRlSPRATFQE 344
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTGTP-VSCFTVRACFSYTgKPIPN--PSLVLNYELELDRQKKKGL-PPRVLFLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 345 TKNRSLSRVRVL--GLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPL--LAFRNLRPMLAADAQRYFTASLPFEKN 420
Cdd:pfam08441  77 SQQPSLTGTLVLlsQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVDPRapSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 421 CGADHICQDNLGIS--FSFPGLKS-LLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQlrslhLT 497
Cdd:pfam08441 157 CGEDNVCVPDLQLSakFDSRESDEpLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGSEKQ-----LS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 498 CDSAPVGSqgTWSTSCRI-NhlIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSEN-NTPRTSKTTfqLELPVKYAV- 574
Cdd:pfam08441 232 CTAKKENS--TRQVVCDLgN--PMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNeQNSNSNPVS--LKVPVVAEAq 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 575 --YTVVSSHEQFtkYLNFSESEEKESHVAM--------HRYQVNNLGQRDLP-VSINFWVPVELnQEAVW----MDVEVS 639
Cdd:pfam08441 306 lsLSGVSKPDQV--VGGSVKGESAMKPRSEedigplveHTYEVINNGPSTVSgASLEISWPYEL-SNGKWllylLDVQGQ 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468428 640 -----HPQ---NP---SLRCSSEKIAPPASDFL------------AHIQKNPVLDC-SIAGCLRFRC 682
Cdd:pfam08441 383 gkgecSPQneiNPlnlTQSLESSKPLRTSRVHHvvkrrdvlksekATQTASVLLSCdSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 104-154 7.46e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.16  E-value: 7.46e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1370468428  104 IGSYFGASLCSV-DVDSDGSTDLVlIGAPHYYEQTRGGQVSVCPLPRGWRRW 154
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLL-VGAPRANDAGETGAVYVYFGSSGGGNS 51
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 167-208 5.60e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.46  E-value: 5.60e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1370468428  167 PWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENR--GAVYLFHG 208
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFG 44
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 779-793 5.13e-05

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 40.56  E-value: 5.13e-05
                          10
                  ....*....|....*
gi 1370468428 779 KVGFFKRQYKEMMEE 793
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 232-278 1.13e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370468428  232 QYFGQALSGGQDLTQDGLVDLAVGA--------RGQVLLLRTRPVLWVGVSMQFI 278
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAprandageTGAVYVYFGSSGGGNSIPLQNL 57
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 266-682 1.01e-31

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 129.36  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 266 RPVLWVGVSMQFIPAEIPRSAFECREQVVSeQTLVQSNICLYID-KRSKNllGSRDLQSSVTLDLALDPGRlSPRATFQE 344
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTGTP-VSCFTVRACFSYTgKPIPN--PSLVLNYELELDRQKKKGL-PPRVLFLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 345 TKNRSLSRVRVL--GLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPL--LAFRNLRPMLAADAQRYFTASLPFEKN 420
Cdd:pfam08441  77 SQQPSLTGTLVLlsQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVDPRapSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 421 CGADHICQDNLGIS--FSFPGLKS-LLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQlrslhLT 497
Cdd:pfam08441 157 CGEDNVCVPDLQLSakFDSRESDEpLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGSEKQ-----LS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 498 CDSAPVGSqgTWSTSCRI-NhlIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSEN-NTPRTSKTTfqLELPVKYAV- 574
Cdd:pfam08441 232 CTAKKENS--TRQVVCDLgN--PMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNeQNSNSNPVS--LKVPVVAEAq 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 575 --YTVVSSHEQFtkYLNFSESEEKESHVAM--------HRYQVNNLGQRDLP-VSINFWVPVELnQEAVW----MDVEVS 639
Cdd:pfam08441 306 lsLSGVSKPDQV--VGGSVKGESAMKPRSEedigplveHTYEVINNGPSTVSgASLEISWPYEL-SNGKWllylLDVQGQ 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468428 640 -----HPQ---NP---SLRCSSEKIAPPASDFL------------AHIQKNPVLDC-SIAGCLRFRC 682
Cdd:pfam08441 383 gkgecSPQneiNPlnlTQSLESSKPLRTSRVHHvvkrrdvlksekATQTASVLLSCdSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 104-154 7.46e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.16  E-value: 7.46e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1370468428  104 IGSYFGASLCSV-DVDSDGSTDLVlIGAPHYYEQTRGGQVSVCPLPRGWRRW 154
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLL-VGAPRANDAGETGAVYVYFGSSGGGNS 51
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 167-208 5.60e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.46  E-value: 5.60e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1370468428  167 PWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENR--GAVYLFHG 208
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 171-206 1.85e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.89  E-value: 1.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370468428 171 FGAALTVlGDVNGDKLTDVVIGAPGE-EENRGAVYLF 206
Cdd:pfam01839   1 FGYSVAV-GDLNGDGYADLAVGAPGEgGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 108-144 1.84e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 42.11  E-value: 1.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370468428 108 FGASLCSVDVDSDGSTDLVlIGAPHYYEQtRGGQVSV 144
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLA-VGAPGEGGA-GAGAVYV 35
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 779-793 5.13e-05

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 40.56  E-value: 5.13e-05
                          10
                  ....*....|....*
gi 1370468428 779 KVGFFKRQYKEMMEE 793
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 232-278 1.13e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370468428  232 QYFGQALSGGQDLTQDGLVDLAVGA--------RGQVLLLRTRPVLWVGVSMQFI 278
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAprandageTGAVYVYFGSSGGGNSIPLQNL 57
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 266-682 1.01e-31

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 129.36  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 266 RPVLWVGVSMQFIPAEIPRSAFECREQVVSeQTLVQSNICLYID-KRSKNllGSRDLQSSVTLDLALDPGRlSPRATFQE 344
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCTLTGTP-VSCFTVRACFSYTgKPIPN--PSLVLNYELELDRQKKKGL-PPRVLFLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 345 TKNRSLSRVRVL--GLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPL--LAFRNLRPMLAADAQRYFTASLPFEKN 420
Cdd:pfam08441  77 SQQPSLTGTLVLlsQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVDPRapSDLPGLKPILDQNQPSTVQEQANFLKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 421 CGADHICQDNLGIS--FSFPGLKS-LLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQlrslhLT 497
Cdd:pfam08441 157 CGEDNVCVPDLQLSakFDSRESDEpLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGSEKQ-----LS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 498 CDSAPVGSqgTWSTSCRI-NhlIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSEN-NTPRTSKTTfqLELPVKYAV- 574
Cdd:pfam08441 232 CTAKKENS--TRQVVCDLgN--PMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNeQNSNSNPVS--LKVPVVAEAq 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370468428 575 --YTVVSSHEQFtkYLNFSESEEKESHVAM--------HRYQVNNLGQRDLP-VSINFWVPVELnQEAVW----MDVEVS 639
Cdd:pfam08441 306 lsLSGVSKPDQV--VGGSVKGESAMKPRSEedigplveHTYEVINNGPSTVSgASLEISWPYEL-SNGKWllylLDVQGQ 382

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370468428 640 -----HPQ---NP---SLRCSSEKIAPPASDFL------------AHIQKNPVLDC-SIAGCLRFRC 682
Cdd:pfam08441 383 gkgecSPQneiNPlnlTQSLESSKPLRTSRVHHvvkrrdvlksekATQTASVLLSCdSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 104-154 7.46e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.16  E-value: 7.46e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1370468428  104 IGSYFGASLCSV-DVDSDGSTDLVlIGAPHYYEQTRGGQVSVCPLPRGWRRW 154
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLL-VGAPRANDAGETGAVYVYFGSSGGGNS 51
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 167-208 5.60e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.46  E-value: 5.60e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1370468428  167 PWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENR--GAVYLFHG 208
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 171-206 1.85e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.89  E-value: 1.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370468428 171 FGAALTVlGDVNGDKLTDVVIGAPGE-EENRGAVYLF 206
Cdd:pfam01839   1 FGYSVAV-GDLNGDGYADLAVGAPGEgGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 108-144 1.84e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 42.11  E-value: 1.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370468428 108 FGASLCSVDVDSDGSTDLVlIGAPHYYEQtRGGQVSV 144
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLA-VGAPGEGGA-GAGAVYV 35
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 779-793 5.13e-05

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 40.56  E-value: 5.13e-05
                          10
                  ....*....|....*
gi 1370468428 779 KVGFFKRQYKEMMEE 793
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 232-278 1.13e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370468428  232 QYFGQALSGGQDLTQDGLVDLAVGA--------RGQVLLLRTRPVLWVGVSMQFI 278
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGAprandageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 180-254 7.34e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 35.66  E-value: 7.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370468428 180 DVNGDKLTDVVIGapgeeeNRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLqYFGqalsggqDLTQDGLVDLAV 254
Cdd:pfam13517   1 DLDGDGKLDLVVA------NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSV-AVG-------DLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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