NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1370466453|ref|XP_024305662|]
View 

N-acetylgalactosamine kinase isoform X6 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 2-394 6.04e-135

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 395.62  E-value: 6.04e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSK---------- 144
Cdd:PLN02521  119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKkevaqftckc 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 145 -----------------------AKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 198
Cdd:PLN02521  199 erhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 199 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 268
Cdd:PLN02521  279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 269 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 343
Cdd:PLN02521  356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466453 344 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 394
Cdd:PLN02521  436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-394 6.04e-135

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 395.62  E-value: 6.04e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSK---------- 144
Cdd:PLN02521  119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKkevaqftckc 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 145 -----------------------AKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 198
Cdd:PLN02521  199 erhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 199 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 268
Cdd:PLN02521  279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 269 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 343
Cdd:PLN02521  356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466453 344 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 394
Cdd:PLN02521  436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-397 1.67e-65

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 213.48  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSANNIQIDKTK 80
Cdd:COG0153     9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  81 PlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLIEFS-------- 151
Cdd:COG0153    87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGqraenefv 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 152 --------------------------PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslq 204
Cdd:COG0153   163 gvpcgimdqfasalgkkghallldcrSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV----- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 205 wdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAAR 284
Cdd:COG0153   237 --KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQR 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 285 VLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSF 363
Cdd:COG0153   273 VLEAVEALRA---GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEF 349

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1370466453 364 LANVHKAYYQRsdGSLAPEkqsLFATKPG-GALEI 397
Cdd:COG0153   350 IEAVAEAYAEK--TGLEPD---FYVVKPSdGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-376 3.02e-64

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 210.45  E-value: 3.02e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanNIQIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  80 KPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------------------------ 134
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLqnmghlpldskqillriqvaenhf 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 135 -----------LTVLGRNlSKAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyks 202
Cdd:TIGR00131 164 vgvncgimdqaASVLGKE-DHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 203 lqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAKHVYSEA 282
Cdd:TIGR00131 239 --------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAKHVVSEN 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 283 ARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLP 361
Cdd:TIGR00131 278 LRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVD 354

                         410
                  ....*....|....*
gi 1370466453 362 SFLANVHKAYYQRSD 376
Cdd:TIGR00131 355 KVRQAVADKYPKKTG 369
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 9.29e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 9.29e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-394 6.04e-135

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 395.62  E-value: 6.04e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSK---------- 144
Cdd:PLN02521  119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKkevaqftckc 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 145 -----------------------AKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 198
Cdd:PLN02521  199 erhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 199 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 268
Cdd:PLN02521  279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 269 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 343
Cdd:PLN02521  356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466453 344 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 394
Cdd:PLN02521  436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-397 1.67e-65

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 213.48  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSANNIQIDKTK 80
Cdd:COG0153     9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  81 PlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLIEFS-------- 151
Cdd:COG0153    87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGqraenefv 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 152 --------------------------PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslq 204
Cdd:COG0153   163 gvpcgimdqfasalgkkghallldcrSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV----- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 205 wdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAAR 284
Cdd:COG0153   237 --KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQR 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 285 VLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSF 363
Cdd:COG0153   273 VLEAVEALRA---GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEF 349

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1370466453 364 LANVHKAYYQRsdGSLAPEkqsLFATKPG-GALEI 397
Cdd:COG0153   350 IEAVAEAYAEK--TGLEPD---FYVVKPSdGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-376 3.02e-64

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 210.45  E-value: 3.02e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanNIQIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  80 KPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------------------------ 134
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLqnmghlpldskqillriqvaenhf 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 135 -----------LTVLGRNlSKAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyks 202
Cdd:TIGR00131 164 vgvncgimdqaASVLGKE-DHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 203 lqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAKHVYSEA 282
Cdd:TIGR00131 239 --------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAKHVVSEN 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 283 ARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLP 361
Cdd:TIGR00131 278 LRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVD 354

                         410
                  ....*....|....*
gi 1370466453 362 SFLANVHKAYYQRSD 376
Cdd:TIGR00131 355 KVRQAVADKYPKKTG 369
PRK05322 PRK05322
galactokinase; Provisional
 2-371 2.01e-39

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 145.00  E-value: 2.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   2 FNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD---FSTSANNIQI 76
Cdd:PRK05322   10 FAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDLDDLSF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  77 DKtKPLWHNYFLCGLKGIQEHfGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLI-------- 148
Cdd:PRK05322   86 DK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVklgqkten 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 149 ---------------------------------EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRVMECRL 192
Cdd:PRK05322  164 efigvnsgimdqfaigmgkkdhailldcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERRAECEK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 193 AakllakykslqwdkvlrLEEVQAKLGI-SLEEmllVTEDALhpepynpeeicrclgislEELRTQILSPNtqdvlifkL 271
Cdd:PRK05322  234 A-----------------LEELQKKLDIkSLGE---LTEEEF------------------DEYSYLIKDET--------L 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 272 YQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGC 350
Cdd:PRK05322  268 LKRARHAVTENQRTLKAVKALKA---GDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGC 344

                         410       420
                  ....*....|....*....|.
gi 1370466453 351 TVSMVPADKLPSFLANVHKAY 371
Cdd:PRK05322  345 AIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 1-375 1.24e-36

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 137.36  E-value: 1.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453   1 MFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP-----VKTYALQLANtnpLYPDFSTSANnIQ 75
Cdd:PRK05101   10 LFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrddriVRVIAADYDN---QQDEFSLDAP-IV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  76 IDKTKpLWHNYFLCGLKGIQEHfgLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAK--------- 146
Cdd:PRK05101   86 PHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEialngqeae 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 147 -------------------------LIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyk 201
Cdd:PRK05101  163 nqfvgcncgimdqlisalgkkdhalLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFFGV-- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 202 slqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntqdvlifkLYQRAKHV 278
Cdd:PRK05101  240 -----KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKRARHV 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 279 YSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSMVP 356
Cdd:PRK05101  269 ITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALVP 345

                         410
                  ....*....|....*....
gi 1370466453 357 ADKLPSFLANVHKAYYQRS 375
Cdd:PRK05101  346 EELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 14-374 1.48e-30

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 120.10  E-value: 1.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  14 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDVLIAVEPVKTYALqlantnplYPDFSTSANNIQIDKTKPL--WHNYFLCG 90
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFIF--------YSENFNEEKTFELDKLEKLnsWADYIKGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  91 LKGIQEHFGlsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKAKLI--------EF------------ 150
Cdd:PRK03817   74 IWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELAllareaenEFvgvpcgimdqfa 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 151 --------------SPLRATDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqa 216
Cdd:PRK03817  152 vafgkkdhaifldtMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE------------ 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 217 klgisleemllVTEDALHpepynpeeicrclgiSLEELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEEap 296
Cdd:PRK03817  219 -----------VTEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALKE-- 254

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370466453 297 eNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 374
Cdd:PRK03817  255 -GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 9.29e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 9.29e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370466453   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK00555 PRK00555
galactokinase; Provisional
 16-370 9.85e-17

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 81.06  E-value: 9.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  16 APGRVNIIGEHIDY-CGYSvLPMAVEQDVLIAVEPVKTYALQLANtnplypDFSTSANNIQIDkTKPlwhnyflcglkgi 94
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTP------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453  95 qehfglSNLTGMNCLVDGNIppssglsssSALVCCA-----GLVTLTV---LGRNLSKAKLIEFSPLRAtdvklpsgavf 166
Cdd:PRK00555   66 ------GQVTGWAAYAAGVI---------WALRGAGhpvpgGAMSITSdveIGSGLSSSAALECAVLGA----------- 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 167 VIANSCVEMNkaatshfniRVMECRLAAKLLAKY----KSLqwdkvlrLEEVQAKLGISLEEMLLVTED-ALHPEPYNP- 240
Cdd:PRK00555  120 VGAATGTRID---------RLEQARLAQRAENEYvgapTGL-------LDQLAALFGAPKTALLIDFRDlTVRPVAFDPd 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 241 -----------------------------EEICRCLGI-SLEELRTQILSP--NTQDVLIFKlyqRAKHVYSEAARVLQF 288
Cdd:PRK00555  184 aagvvlllmdsrarhrhaggeyaarrascERAAADLGVsSLRAVQDRGLAAlgAIADPIDAR---RARHVLTENQRVLDF 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 289 KKICEEAPenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVH 368
Cdd:PRK00555  261 AAALADSD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVR 337


                  ..
gi 1370466453 369 KA 370
Cdd:PRK00555  338 RA 339
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 270-354 1.79e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.87  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 270 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 349
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1370466453 350 CTVSM 354
Cdd:PTZ00298  288 LVVAL 292
PLN02865 PLN02865
galactokinase
 167-394 2.64e-10

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 61.74  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 167 VIANSCVEMNKAATSHFNIRVMECRLAAKLLAKYKSLqwdkvlrlEEVQAKLGisleemllvtedALHPEPYnpeeicrc 246
Cdd:PLN02865  234 LLAFSGLRHALTNKPGYNLRVSECQEAARFLLEASGN--------DELEPLLC------------NVEPEVY-------- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 247 lgisleELRTQILSPNtqdvlifkLYQRAKHVYSEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELD 326
Cdd:PLN02865  286 ------EAHKCKLEAV--------LARRAEHYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLI 348

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370466453 327 QLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGGA 394
Cdd:PLN02865  349 QLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDC 419
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 270-350 1.05e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 58.70  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 270 KLYQRAKHVYseAARVLQFKKICEEAPENMVQ----LLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSRLT 343
Cdd:COG1577   191 KLKERNPELY--EAFLEEIGDLVEEAIEALEEgdleALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLT 265


                  ....*..
gi 1370466453 344 GAGWGGC 350
Cdd:COG1577   266 GAGGGGC 272
PTZ00290 PTZ00290
galactokinase; Provisional
 272-374 2.76e-09

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 58.68  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 272 YQRAKHVYSEAARVLQFKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQLVD-ICRKFGAQGSRLTGAG 346
Cdd:PTZ00290  330 FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGG 409

                          90       100
                  ....*....|....*....|....*...
gi 1370466453 347 WGGCTVSMVPADKLPSFLANVHKAYYQR 374
Cdd:PTZ00290  410 FGGCIILLLKKNAVDRVVAHVREKFKAR 437
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 300-352 4.75e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 56.92  E-value: 4.75e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370466453 300 VQLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 352
Cdd:TIGR00549 220 VESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 293-373 9.60e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 52.09  E-value: 9.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 293 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 369
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1370466453 370 AYYQ 373
Cdd:pfam08544  82 AGKK 85
PRK03926 PRK03926
mevalonate kinase; Provisional
 303-359 1.54e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370466453 303 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 359
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 273-382 9.06e-06

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 9.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466453 273 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 343
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1370466453 344 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 382
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH