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Conserved domains on  [gi|1370466446|ref|XP_024305660|]
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N-acetylgalactosamine kinase isoform X4 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 2-427 1.85e-157

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 454.55  E-value: 1.85e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKS 154
Cdd:PLN02521  119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 155 ERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 231
Cdd:PLN02521  199 ERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 232 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 301
Cdd:PLN02521  279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 302 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 376
Cdd:PLN02521  356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466446 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 427
Cdd:PLN02521  436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-427 1.85e-157

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 454.55  E-value: 1.85e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKS 154
Cdd:PLN02521  119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 155 ERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 231
Cdd:PLN02521  199 ERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 232 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 301
Cdd:PLN02521  279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 302 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 376
Cdd:PLN02521  356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466446 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 427
Cdd:PLN02521  436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-430 9.75e-85

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 264.33  E-value: 9.75e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSANNIQIDKTK 80
Cdd:COG0153     9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  81 PlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYI 158
Cdd:COG0153    87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 159 GTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslq 237
Cdd:COG0153   163 GVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV----- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 238 wdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAAR 317
Cdd:COG0153   237 --KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQR 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 318 VLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSF 396
Cdd:COG0153   273 VLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEF 349

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1370466446 397 LANVHKAYYQRsdGSLAPEkqsLFATKPG-GALEI 430
Cdd:COG0153   350 IEAVAEAYAEK--TGLEPD---FYVVKPSdGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-409 5.25e-78

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 247.04  E-value: 5.25e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanNIQIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  80 KPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSER 156
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 157 YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyks 235
Cdd:TIGR00131 163 FVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 236 lqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAKHVYSEA 315
Cdd:TIGR00131 239 --------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAKHVVSEN 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 316 ARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLP 394
Cdd:TIGR00131 278 LRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVD 354

                         410
                  ....*....|....*
gi 1370466446 395 SFLANVHKAYYQRSD 409
Cdd:TIGR00131 355 KVRQAVADKYPKKTG 369
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 1.18e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.18e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-427 1.85e-157

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 454.55  E-value: 1.85e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521   39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKS 154
Cdd:PLN02521  119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 155 ERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 231
Cdd:PLN02521  199 ERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 232 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 301
Cdd:PLN02521  279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 302 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 376
Cdd:PLN02521  356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466446 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 427
Cdd:PLN02521  436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-430 9.75e-85

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 264.33  E-value: 9.75e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSANNIQIDKTK 80
Cdd:COG0153     9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  81 PlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYI 158
Cdd:COG0153    87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 159 GTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslq 237
Cdd:COG0153   163 GVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV----- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 238 wdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAAR 317
Cdd:COG0153   237 --KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQR 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 318 VLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSF 396
Cdd:COG0153   273 VLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEF 349

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1370466446 397 LANVHKAYYQRsdGSLAPEkqsLFATKPG-GALEI 430
Cdd:COG0153   350 IEAVAEAYAEK--TGLEPD---FYVVKPSdGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-409 5.25e-78

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 247.04  E-value: 5.25e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanNIQIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  80 KPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSER 156
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 157 YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyks 235
Cdd:TIGR00131 163 FVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 236 lqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAKHVYSEA 315
Cdd:TIGR00131 239 --------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAKHVVSEN 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 316 ARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLP 394
Cdd:TIGR00131 278 LRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVD 354

                         410
                  ....*....|....*
gi 1370466446 395 SFLANVHKAYYQRSD 409
Cdd:TIGR00131 355 KVRQAVADKYPKKTG 369
PRK05322 PRK05322
galactokinase; Provisional
 2-404 4.00e-50

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 174.28  E-value: 4.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   2 FNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD---FSTSANNIQI 76
Cdd:PRK05322   10 FAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDLDDLSF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  77 DKtKPLWHNYFLCGLKGIQEHfGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE- 155
Cdd:PRK05322   86 DK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTEn 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 156 RYIGTEGGGMDQSISFLAEEGTAKLI-------EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRVMECRL 225
Cdd:PRK05322  164 EFIGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERRAECEK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 226 AakllakykslqwdkvlrLEEVQAKLGI-SLEEmllVTEDAlhpepynpeeicrclgisLEELRTQILSPNtqdvlifkL 304
Cdd:PRK05322  234 A-----------------LEELQKKLDIkSLGE---LTEEE------------------FDEYSYLIKDET--------L 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 305 YQRAKHVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGC 383
Cdd:PRK05322  268 LKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGC 344

                         410       420
                  ....*....|....*....|.
gi 1370466446 384 TVSMVPADKLPSFLANVHKAY 404
Cdd:PRK05322  345 AIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 1-408 6.63e-50

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 173.57  E-value: 6.63e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446   1 MFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP-----VKTYALQLANtnpLYPDFSTSAnNIQ 75
Cdd:PRK05101   10 LFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrddriVRVIAADYDN---QQDEFSLDA-PIV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  76 IDKTKpLWHNYFLCGLKGIQEHfgLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE 155
Cdd:PRK05101   86 PHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 156 -RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyk 234
Cdd:PRK05101  163 nQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFFGV-- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 235 slqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntqdvlifkLYQRAKHV 311
Cdd:PRK05101  240 -----KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKRARHV 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 312 YSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSMVP 389
Cdd:PRK05101  269 ITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALVP 345

                         410
                  ....*....|....*....
gi 1370466446 390 ADKLPSFLANVHKAYYQRS 408
Cdd:PRK05101  346 EELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 14-407 1.89e-42

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 152.84  E-value: 1.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  14 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDVLIAVEPVKTYAlqlantnpLYPDFSTSANNIQIDKTKPL--WHNYFLCG 90
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFI--------FYSENFNEEKTFELDKLEKLnsWADYIKGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  91 LKGIQEHFGlsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 169
Cdd:PRK03817   74 IWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQFA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 170 SFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqa 249
Cdd:PRK03817  152 VAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE------------ 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 250 klgisleemllVTEDALHpepynpeeicrclgiSLEELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEeap 329
Cdd:PRK03817  219 -----------VTEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALK--- 253

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370466446 330 ENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 407
Cdd:PRK03817  254 EGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 16-403 2.93e-26

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 108.79  E-value: 2.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  16 APGRVNIIGEHIDY-CGYSvLPMAVEQDVLIAVEPVKTYALQLANtnplypDFSTSANNIQIDkTKPL----WHNYFLCG 90
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  91 LKGIQEHFglSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 169
Cdd:PRK00555   79 IWALRGAG--HPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 170 SFLAEEGTAKLIEFSPLRATDVKLPSGA--VFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAkykslqwdkVLRLEEV 247
Cdd:PRK00555  157 ALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLG---------VSSLRAV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 248 QAKLGISLeemllvtedalhpepynpeeicrclgisleelrTQILSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEE 327
Cdd:PRK00555  228 QDRGLAAL---------------------------------GAIADPID--------ARRARHVLTENQRVLDFAAALAD 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370466446 328 APenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKA 403
Cdd:PRK00555  267 SD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRA 339
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 1.18e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.18e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370466446   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PTZ00290 PTZ00290
galactokinase; Provisional
 16-407 6.14e-17

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 82.56  E-value: 6.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  16 APGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYA---LQLANTNPLYpdfstsannIQIDKTKPLWHN----YFL 88
Cdd:PTZ00290   42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKHFCdhkLRFATETDEH---------FVLDHLGGAKHNkawtTFV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  89 CGLKGIQ-EHFGLS----NLTGMNCLVDGNIPPSSGLSSSSAL-VCCAGLVTLTVLGR----------------NLSKVE 146
Cdd:PTZ00290  113 RGAATLRlNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASFgVALLNAINTVVTRRykgcptspgrrysilpPMSKEE 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 147 LAEIcAKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvkLPSGAVFVIANSCVEMNka 211
Cdd:PTZ00290  193 LIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIKHD-- 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 212 atshfnirvmecrLAAKLLAKYKSLQWDkvlrLEEVQAKLG--ISLEEMLLVTEDALHPEPY----NPEEIcrclgisLE 285
Cdd:PTZ00290  264 -------------LLGGTAGMYNTVRSD----QEGAQKKIGkhRYRGKPFTFSDLVRNPKKYtfdgDVVAF-------ME 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 286 ELRTQiLSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQL 361
Cdd:PTZ00290  320 SCKPL-MTPGE--------FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFI 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1370466446 362 VD-ICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 407
Cdd:PTZ00290  391 HElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 16-383 7.08e-14

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 71.41  E-value: 7.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  16 APGRVNIIGEHID-YcGYSVLPMAVEQDVLIAVEPVKTYALQLantnplYPDFSTSANNIQIDKTKPLwhNYFLCGLKGI 94
Cdd:COG1577     1 APGKLILFGEHAVvY-GQPAIAVAVDRRATVTVEPSDDDKLRI------ESPDLGGTLDLDPLADAAL--RYIKAAIEAA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  95 QEHFGLSNlTGMNCLVDGNIPPSsglssssalvccAGL-----VT-------LTVLGRNLSKVELAEICAKSERYIGTEG 162
Cdd:COG1577    72 LEYLGLPL-KGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNP 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 163 GGMDQSISFLaeEGtakLIEF-SPLRATDVKLPSGAVFVIANSCVemnKAATSHfnirvmecrLAAKLLAKYKSlqwdkv 241
Cdd:COG1577   139 SGLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKE---------LVAKVRKLKER------ 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 242 lrleevqaklgisleemllvtedalHPEPYNPeeicrclgisleelrtqilspntqdvlifkLYQRAKHVYSEAARVLQf 321
Cdd:COG1577   196 -------------------------NPELYEA------------------------------FLEEIGDLVEEAIEALE- 219

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370466446 322 kkiceeapENMVQLLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSRLTGAGWGGC 383
Cdd:COG1577   220 --------EGDLEALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLTGAGGGGC 272
PLN02865 PLN02865
galactokinase
 14-427 6.09e-13

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 70.22  E-value: 6.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  14 VRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP-----VKTYALQLANTNPLYPDFSTSANNIQIDKTKP--LWHNY 86
Cdd:PLN02865   33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPsgdpeVLLRSAQFEGEVRFRVDEIQHPIANVSSDSKEesNWGDY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  87 FLCGLKGIQEhFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------LTVlgRNLSKVELAEICakSERYIGT 160
Cdd:PLN02865  113 ARGAVYALQS-RGHALSQGITGYISGSEGLDSSGLSSSAAVGVAYLLAlenannLTV--SPEDNIELDRLI--ENEYLGL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 161 EGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAV-------FVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKY 233
Cdd:PLN02865  188 RNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARFLLEA 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 234 KSLqwdkvlrlEEVQAKLGisleemllvtedALHPEPYnpeeicrclgisleELRTQILSPNtqdvlifkLYQRAKHVYS 313
Cdd:PLN02865  268 SGN--------DELEPLLC------------NVEPEVY--------------EAHKCKLEAV--------LARRAEHYFS 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 314 EAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADK 392
Cdd:PLN02865  306 ENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAEM 382

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1370466446 393 LPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGGA 427
Cdd:PLN02865  383 AEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDC 419
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 303-387 2.56e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 2.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 303 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 382
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1370466446 383 CTVSM 387
Cdd:PTZ00298  288 LVVAL 292
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 16-385 1.40e-10

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 61.54  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  16 APGRVNIIGEHIDYCGYSVLPMAVEQ-DVLIAVEPVKTYALQLANTNPLYPDFSTSANNIqidktkplwHNYFLCGLKgi 94
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLrTTVTVIESSDGSFIESDLGRGSLDDAPDELDGL---------KYVLAEFLS-- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446  95 qeHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISflae 174
Cdd:TIGR00549  70 --RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATS---- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 175 eGTAKLIEFSPLRATDVKLPS-GAVFVIANSCVEmnkaatshfnirvmecRLAAKLLAKYKSLqwdkvlrLEEvqaklgi 253
Cdd:TIGR00549 144 -TSGGPVYFEKGEGEFTKLISlDGYFVIADTGVS----------------GSTKEAVARVRQL-------LER------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 254 sleemllvtedalHPEpynpeeicrclgisleelrtqilspntqdvLIFKLYQRAKHVYSEAARVLQFKKiceeapenmV 333
Cdd:TIGR00549 193 -------------FPE------------------------------LIDSIMDAIGELTLEAKAALQDGD---------V 220

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370466446 334 QLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 385
Cdd:TIGR00549 221 ESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
PRK03926 PRK03926
mevalonate kinase; Provisional
 336-392 1.76e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370466446 336 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 392
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 326-406 1.77e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 326 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 402
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1370466446 403 AYYQ 406
Cdd:pfam08544  82 AGKK 85
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 306-415 1.03e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466446 306 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 376
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1370466446 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 415
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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