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Conserved domains on  [gi|1370464773|ref|XP_024305291|]
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ral GTPase-activating protein subunit alpha-1 isoform X10 [Homo sapiens]

Protein Classification

GTPase-activating protein( domain architecture ID 10489639)

GTPase-activating protein functions as a GTPase activator for small GTPases, similar to Homo sapiens Rap1 GTPase-activating protein 2, a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state

CATH:  3.40.50.11210|2.20.140.30
Gene Ontology:  GO:0051056|GO:0005096

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1316-1489 2.47e-62

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 210.45  E-value: 2.47e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464773 1316 LTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1393
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDtKNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464773 1394 DEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNH----MFSIQIMKKPEVPFFGP-LFDGAIVNGKVLPIMVRATAIN 1468
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160

                          170       180
                   ....*....|....*....|.
gi 1370464773 1469 ASRALkslipLYQNFYEERAR 1489
Cdd:pfam02145  161 AERAA-----LKSSSFAERLR 176
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1316-1489 2.47e-62

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 210.45  E-value: 2.47e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464773 1316 LTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1393
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDtKNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464773 1394 DEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNH----MFSIQIMKKPEVPFFGP-LFDGAIVNGKVLPIMVRATAIN 1468
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160

                          170       180
                   ....*....|....*....|.
gi 1370464773 1469 ASRALkslipLYQNFYEERAR 1489
Cdd:pfam02145  161 AERAA-----LKSSSFAERLR 176
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1316-1489 2.47e-62

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 210.45  E-value: 2.47e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464773 1316 LTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1393
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDtKNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464773 1394 DEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNH----MFSIQIMKKPEVPFFGP-LFDGAIVNGKVLPIMVRATAIN 1468
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160

                          170       180
                   ....*....|....*....|.
gi 1370464773 1469 ASRALkslipLYQNFYEERAR 1489
Cdd:pfam02145  161 AERAA-----LKSSSFAERLR 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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