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Conserved domains on  [gi|1370463954|ref|XP_024305148|]
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ankyrin repeat domain-containing protein 10 isoform X1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 1.24e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 1.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEA--GADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGN 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666   166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 1.24e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 1.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEA--GADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGN 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666   166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
97-179 2.47e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 2.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  97 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANgAHVDLRNaSGLTAADIAQTQGFQECAQF 176
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  ...
gi 1370463954 177 LLN 179
Cdd:pfam12796  80 LLE 82
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 22-162 3.47e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  22 LRFPLHRACRDGDLATLCSLLQQTPHAhlasEDSFY--GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAqTPAHIA 99
Cdd:PHA02875   68 IESELHDAVEEGDVKAVEELLDLGKFA----DDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF-SPLHLA 142

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370463954 100 AFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162
Cdd:PHA02875  143 VMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-86 1.24e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370463954   57 YGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 54-178 1.13e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  54 DSFY-GWTPVHWAAHFGKLECLVQLVRAGATLNVSTT-------------RYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
Cdd:TIGR00870 123 SEFTpGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 120 KPDCEGETPIHKAA---------RSGSLECISALVANGAHVD-------LRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:TIGR00870 203 TADSLGNTLLHLLVmenefkaeyEELSCQMYNFALSLLDKLRdskelevILNHQGLTPLKLAAKEGRIVLFRLKL 277
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 1.24e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 1.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEA--GADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGN 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666   166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
57-179 1.50e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  57 YGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSG 136
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNA-RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1370463954 137 SLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666   165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-180 1.73e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.41  E-value: 1.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEA--GADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNA-RDNDGETPLHLAAENGH 198

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463954 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
Cdd:COG0666   199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-192 1.45e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  19 LLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSfygwTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHI 98
Cdd:COG0666    18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALG----ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  99 AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:COG0666    94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                         170
                  ....*....|....
gi 1370463954 179 NlQNCHLNHFYNNG 192
Cdd:COG0666   174 E-AGADVNARDNDG 186
Ank_2 pfam12796
Ankyrin repeats (3 copies);
97-179 2.47e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 2.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  97 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANgAHVDLRNaSGLTAADIAQTQGFQECAQF 176
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  ...
gi 1370463954 177 LLN 179
Cdd:pfam12796  80 LLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
63-155 1.62e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 1.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  63 HWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQaGANINKpDCEGETPIHKAARSGSLECIS 142
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLE-HADVNL-KDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1370463954 143 ALVANGAHVDLRN 155
Cdd:pfam12796  79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-162 3.30e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 77.30  E-value: 3.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEA--GADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGN 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463954 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162
Cdd:COG0666   232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
26-122 7.63e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 7.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  26 LHRACRDGDLATLCSLLQQTPHAHLASEDsfyGWTPVHWAAHFGKLECLVQLVragATLNVSTTRYAQTPAHIAAFGGHP 105
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN---GRTALHLAAKNGHLEIVKLLL---EHADVNLKDNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1370463954 106 QCLVWLIQAGANINKPD 122
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
94-145 4.84e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.28  E-value: 4.84e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370463954  94 TPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 22-162 3.47e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  22 LRFPLHRACRDGDLATLCSLLQQTPHAhlasEDSFY--GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAqTPAHIA 99
Cdd:PHA02875   68 IESELHDAVEEGDVKAVEELLDLGKFA----DDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF-SPLHLA 142

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370463954 100 AFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162
Cdd:PHA02875  143 VMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
Ank_5 pfam13857
Ankyrin repeats (many copies);
111-165 1.14e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.81  E-value: 1.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463954 111 LIQAG-ANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 24-165 1.19e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  24 FPLHRACRDGDLATLCSLLQQTPHAHLaseDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRyAQTPAHIAAFgg 103
Cdd:PHA02874  159 YPIHIAIKHNFFDIIKLLLEKGAYANV---KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN-GFTPLHNAII-- 232

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370463954 104 HPQCLVWLIQAGANINKPDCEGETPIHKAAR-SGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:PHA02874  233 HNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_4 pfam13637
Ankyrin repeats (many copies);
127-178 2.24e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 2.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370463954 127 TPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-178 3.62e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.87  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  65 AAHFGKLECLVQLVRAGATLNVSTTRyAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI--------HK----- 131
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhHKifril 610

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 132 ------------------AARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:PLN03192  611 yhfasisdphaagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_4 pfam13637
Ankyrin repeats (many copies);
58-112 5.70e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 5.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954  58 GWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLI 112
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 57-164 1.13e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  57 YGWTPVHWAAHFGKLECL--VQ-LVRAGATLNVsTTRYAQTPAHI-AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKA 132
Cdd:PHA03095   46 YGKTPLHLYLHYSSEKVKdiVRlLLEAGADVNA-PERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVY 124

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1370463954 133 ARSGSL--ECISALVANGAHVDLRNASGLTAADI 164
Cdd:PHA03095  125 LSGFNInpKVIRLLLRKGADVNALDLYGMTPLAV 158
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 77-212 5.39e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 5.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  77 LVRAGATLNVSTtRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156
Cdd:PHA02874  110 ILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463954 157 SGLTAADIAQTQGFQECAQFLLNlqncHLNHfynngILNGGHQNVFPNHISVGTNR 212
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLID----HGNH-----IMNKCKNGFTPLHNAIIHNR 235
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 77-165 7.41e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.26  E-value: 7.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  77 LVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156
Cdd:PHA02878  153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232


                  ....*....
gi 1370463954 157 SGLTAADIA 165
Cdd:PHA02878  233 CGNTPLHIS 241
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-160 9.22e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 9.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYgwtPVHWAAHFGKLECLVQLVRAGATLNVSTTrYAQTPAHIAAFGGHP 105
Cdd:PHA02874  128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCY---PIHIAIKHNFFDIIKLLLEKGAYANVKDN-NGESPLHNAAEYGDY 203

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463954 106 QCLVWLIQAGANINKPDCEGETPIHKAA---RSgslecISALVANGAHVDLRNASGLT 160
Cdd:PHA02874  204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIihnRS-----AIELLINNASINDQDIDGST 256
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-155 1.37e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACR-DGDLATLCSLLQQTphAHLASEDsFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAqTPAHIAAFGG 103
Cdd:PHA02876  344 PLHQASTlDRNKDIVITLLELG--ANVNARD-YCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG-TALHFALCGT 419

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370463954 104 HPQCLV-WLIQAGANINKPDCEGETPIHKAARSG-SLECISALVANGAHVDLRN 155
Cdd:PHA02876  420 NPYMSVkTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAIN 473
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-179 2.64e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.11  E-value: 2.64e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370463954 129 IHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 111-186 4.06e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 4.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463954 111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 26-152 8.75e-06

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 44.87  E-value: 8.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  26 LHRACRDGDLATLCSLLQQTPHA--HLASEDSFYGWTPVHWAAHFGKL---ECLVQLVRAGATLNVSTTRYAQTPAHIAA 100
Cdd:PHA02736   21 LHYLCRNGGVTDLLAFKNAISDEnrYLVLEYNRHGKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKERVFGNTPLHIAV 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370463954 101 FGGHPQCLVWLI-QAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:PHA02736  101 YTQNYELATWLCnQPGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGAQCK 153
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 60-192 1.74e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLE 139
Cdd:PHA02875   70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370463954 140 CISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNlQNCHLNHFYNNG 192
Cdd:PHA02875  150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNG 201
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-152 1.80e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.21  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLC-SLLQQTPHAhlaSEDSFYGWTPVHWAAHFG-KLECLVQLVRAGATLNVSTTRYaQTPAHIAA-F 101
Cdd:PHA02876  276 PLHHASQAPSLSRLVpKLLERGADV---NAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLY-ITPLHQAStL 351

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370463954 102 GGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:PHA02876  352 DRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE 402
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-129 3.05e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 3.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370463954  58 GWTPVHWAAHFGKLECLV--QLVRAGATLNvSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI 129
Cdd:PHA03095  222 GNTPLHSMATGSSCKRSLvlPLLIAGISIN-ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
Ank_5 pfam13857
Ankyrin repeats (many copies);
77-132 3.33e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 3.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463954  77 LVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKA 132
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-86 4.28e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 4.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370463954  23 RFPLHRACRDGDLATLCSLLQqtphaHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLE-----HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 23-147 5.73e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 5.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  23 RFPLHRACRDGDLATLCSLLQQTphahlASED--SFYGWTPVHWAAHFGK-LECLVQLVRAGATLNVSTTRYAQTPAHIA 99
Cdd:PHA02878  202 NSPLHHAVKHYNKPIVHILLENG-----ASTDarDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSYILGLTALHSS 276

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370463954 100 AFGghPQCLVWLIQAGANINKPDCEGETPIHKAARSGS-LECISALVAN 147
Cdd:PHA02878  277 IKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRILISN 323
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-86 1.24e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 1.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370463954   57 YGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
25-74 1.74e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370463954  25 PLHRACRDGDLATLCSLLQQTPHAHLASEDsfyGWTPVHWAAHFGKLECL 74
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGN---GETALHFAASNGNVEVL 50
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 111-165 3.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 3.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:PHA03100  178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 72-165 4.11e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  72 ECLVQLVRAGATLNvSTTRYAQTPAHIAAFGGHPQCLVW--LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGA 149
Cdd:PHA03095  203 RIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281

                          90
                  ....*....|....*.
gi 1370463954 150 HVDLRNASGLTAADIA 165
Cdd:PHA03095  282 DINAVSSDGNTPLSLM 297
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-155 4.88e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  77 LVRAGATLNVsTTRYAQTPAHIAAFG--GHPQCLVWLIQAGANINKPDCEGETPIHKAARSGS--LECISALVANGAHVD 152
Cdd:PHA03100   92 LLEYGANVNA-PDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDIN 170


                  ...
gi 1370463954 153 LRN 155
Cdd:PHA03100  171 AKN 173
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 124-152 8.11e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 8.11e-04
                          10        20
                  ....*....|....*....|....*....
gi 1370463954 124 EGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 124-155 9.47e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 9.47e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1370463954 124 EGETPIHKAA-RSGSLECISALVANGAHVDLRN 155
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 54-178 1.13e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  54 DSFY-GWTPVHWAAHFGKLECLVQLVRAGATLNVSTT-------------RYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
Cdd:TIGR00870 123 SEFTpGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 120 KPDCEGETPIHKAA---------RSGSLECISALVANGAHVD-------LRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:TIGR00870 203 TADSLGNTLLHLLVmenefkaeyEELSCQMYNFALSLLDKLRdskelevILNHQGLTPLKLAAKEGRIVLFRLKL 277
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 111-161 1.36e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 1.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370463954 111 LIQAGANINKPDCEGETPIHKAA--RSGSLECISALVANGAHVDLRNASGLTA 161
Cdd:PHA03100   92 LLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENL 144
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 94-120 1.40e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370463954   94 TPAHIAAFGGHPQCLVWLIQAGANINK 120
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 77-144 1.44e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 1.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463954  77 LVRAGATLNvSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
Cdd:PTZ00322  101 LLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 57-119 1.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370463954  57 YGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
Cdd:PHA03100  191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 91-152 1.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370463954  91 YAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:PHA03100  191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 111-165 1.82e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.05  E-value: 1.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370463954 111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 93-122 2.43e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370463954  93 QTPAHIAA-FGGHPQCLVWLIQAGANINKPD 122
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 124-153 2.69e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.69e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370463954  124 EGETPIHKAARSGSLECISALVANGAHVDL 153
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 49-134 5.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.04  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  49 HLASEDSFYgwTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETP 128
Cdd:PHA02884   63 FPLSENSKT--NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTP 140


                  ....*.
gi 1370463954 129 IHKAAR 134
Cdd:PHA02884  141 IELALM 146
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 77-161 6.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.12  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463954  77 LVRAGATLNVSTTrYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156
Cdd:PHA02876  164 LLEGGADVNAKDI-YCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDL 242


                  ....*
gi 1370463954 157 SGLTA 161
Cdd:PHA02876  243 SLLKA 247
PHA03095 PHA03095
ankyrin-like protein; Provisional
 111-161 7.25e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 7.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370463954 111 LIQAGANINKPDCEGETPIHKAARSGS---LECISALVANGAHVDLRNASGLTA 161
Cdd:PHA03095   33 LLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTP 86
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-88 7.93e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.42  E-value: 7.93e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1370463954  57 YGWTPVHWAA-HFGKLECLVQLVRAGATLNVST 88
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-86 9.67e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 9.67e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1370463954  57 YGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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