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Conserved domains on  [gi|1370462868|ref|XP_024304957|]
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SREBP regulating gene protein isoform X1 [Homo sapiens]

Protein Classification

SREBP regulating gene protein( domain architecture ID 10562938)

SREBP regulating gene protein positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP

Gene Ontology:  GO:2000640
PubMed:  32111832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 73-196 9.16e-68

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


:

Pssm-ID: 463004  Cd Length: 128  Bit Score: 203.37  E-value: 9.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462868  73 SNQCRNSIQGKHLITDELGYVCERKDLLVNGCCN---VNVPSTKQYCCDGCW-PNGCCSAYEYCVSCCLQPNKQLLLERF 148
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLSNGCCNttgVNAPTTKRYSCDTCNlSSRCCSVYEYCVSCCLHPDKRPLLEVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370462868 149 LNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCY 196
Cdd:pfam10218  81 LKKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 73-196 9.16e-68

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 203.37  E-value: 9.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462868  73 SNQCRNSIQGKHLITDELGYVCERKDLLVNGCCN---VNVPSTKQYCCDGCW-PNGCCSAYEYCVSCCLQPNKQLLLERF 148
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLSNGCCNttgVNAPTTKRYSCDTCNlSSRCCSVYEYCVSCCLHPDKRPLLEVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370462868 149 LNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCY 196
Cdd:pfam10218  81 LKKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 73-196 9.16e-68

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 203.37  E-value: 9.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462868  73 SNQCRNSIQGKHLITDELGYVCERKDLLVNGCCN---VNVPSTKQYCCDGCW-PNGCCSAYEYCVSCCLQPNKQLLLERF 148
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLSNGCCNttgVNAPTTKRYSCDTCNlSSRCCSVYEYCVSCCLHPDKRPLLEVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370462868 149 LNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCY 196
Cdd:pfam10218  81 LKKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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