|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
750-1056 |
4.03e-166 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 495.56 E-value: 4.03e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 750 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGrnQG 829
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 830 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 909
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 910 NPIVRNALFCLESAWNVAkegthgSHVYTKALLAYAFSLLGkQNQNREILNSLDKEAVKEDNLVHWERPqrPKAPVGHLY 989
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370462546 990 QTQAPSAEVEMTSYVLLAYLTAQPAptsgDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1056
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGGE----DLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
613-700 |
1.16e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.87 E-value: 1.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 613 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 692
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
....*...
gi 1370462546 693 LPKCIRAE 700
Cdd:pfam00207 81 LDKCLKVR 88
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1166-1255 |
2.92e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.45 E-value: 2.92e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1166 PASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTE-VSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDY 1244
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|.
gi 1370462546 1245 YETDESVVAEY 1255
Cdd:pfam07677 81 YEPERRATTFY 91
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
35-1225 |
1.74e-32 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 137.90 E-value: 1.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 35 LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVVVQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDE 112
Cdd:COG2373 409 LTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGD 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 113 KVNITVCGEYTYGKPVPGL-ATVSLCRKLS-------------RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitN 178
Cdd:COG2373 488 PVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyrfgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--D 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 179 TGFEMKLRVEARIREEGTDlEVTAnriSEITNIVSKLKFVKV----DSHFRQGIPFFAQVLLVDGKGVPIPN-----KLF 249
Cdd:COG2373 566 APGPLRATVEASVFESGGR-PVTR---SATVPVHPADFYVGIrlplFDGDPEGAPATFEVVAVDPDGKPVAGkglkvELY 641
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 250 --------FISVNDANYYSNATTNEQgLAQFSINTTSISVNKlfVRVFTVHPNlcfHYSWVAEDHQGaQHTANRVFSLSG 321
Cdd:COG2373 642 reewryvwYKSDDGGWRYESQEKEEP-VAEGTLTTGADGPAS--LSLTPVEWG---RYRLEVKDPDG-GLATSVRFYAGG 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 322 SYIHLEPVAGTLpcghteTITahytLNRQ--AMGELSELSF------HYLIMakgvIVRSG---THTLPVEsgdmKGSFA 390
Cdd:COG2373 715 NASWGAERPDRL------ELS----LDKEsyKPGETAKLLIqspfagRALVT----VERDGvleTQWVDVK----GGGTT 776
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 391 LSFPVESDVAP-------------------IARMFIFAILPdgevVGDSEKfeienclANKVDLSfSPAQSPPASHAHLQ 451
Cdd:COG2373 777 VEIPVTEDWAPnayvsatlvrpgdstandmPARAYGVAPLP----VDPPAR-------RLKVELT-APEKLRPGETLTVT 844
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 452 V----AAAPQSLCALRAVDQSVLlmkpeaelsvssvynlltvkDLTNF--PDnvdqqeeeqghcPRPFFIHNGAIYVPLS 525
Cdd:COG2373 845 VkvkgAAGKAAEVTLAAVDEGIL--------------------NLTGYktPD------------PLDFFYGKRALGVETR 892
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 526 sneaDIYSFLkgMGLKVFTNSKIRKpkscsvipsvsaGAVGqgyyGAGLGVVERPyvpqlgtynviplnneqssgpvpet 605
Cdd:COG2373 893 ----DLYGRL--IGAFGGAAGALRS------------GGDG----ALGRGGNPKP------------------------- 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 606 VRSYFPETWIWE-LVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEVFT 684
Cdd:COG2373 926 PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFE 1003
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 685 LKATVLNYLPKC------IRAEGI-----EQEKTFS-----------------------SMTCASG-------------- 716
Cdd:COG2373 1004 LPVDVFNLTGKAgtvtvtLEASGGltlegEATQTVTlaaggratvrfplkapdagdakvTVTATGGgesdarevelpvrp 1083
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 717 --------------ANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNyL 782
Cdd:COG2373 1084 anplvtratsgvlaPGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-L 1162
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 783 NETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARSY-IFIDEAHITQSLTW 861
Cdd:COG2373 1163 AEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDY 1239
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 862 LSQMQKDNGcfrssgsllnnAIKGGVEDEATLSAYVTIALLEIPLPVTNPivrnalfcLESAWNVAKEGTHGshvYTKAL 941
Cdd:COG2373 1240 LRNYLRNPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGD--------LRYLYDRRKDALSP---LAKAQ 1297
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 942 LAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWerpqrpkapvGHLYQTqapsaEVEMTSYVLLAYLTAQPAPTSgdlt 1021
Cdd:COG2373 1298 LAAALALLGDKARAEELLAAALARLRETGARDYW----------YGDYGS-----PLRDQALALALLAELGPDAPL---- 1358
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1022 sATNIVKWIMKQQNaQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDsqtfsTNFQVDNNNLLLLQQISLPEL- 1100
Cdd:COG2373 1359 -APKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRGPLARVTLPAAELl 1431
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1101 PGEYVITVTGERCVYLQTSMKYNILPEKE---DSPFALKVQ---TVPQTCDGHKAH--TSFQISLTISyTGNRPASNMVI 1172
Cdd:COG2373 1432 AGPLTITNTGDGPLYYTLTLSGYPAEGPPpaaSNGLEIERRyydLDGKPIDPASLKqgDLVVVRLTVT-APSGRVENVAV 1510
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370462546 1173 VDvkMV-SGFIPLKP-------TVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMV 1225
Cdd:COG2373 1511 VD--PLpAGFEIENPrlatsgdLGDWLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLV 1569
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
750-1056 |
4.03e-166 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 495.56 E-value: 4.03e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 750 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGrnQG 829
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 830 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 909
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 910 NPIVRNALFCLESAWNVAkegthgSHVYTKALLAYAFSLLGkQNQNREILNSLDKEAVKEDNLVHWERPqrPKAPVGHLY 989
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370462546 990 QTQAPSAEVEMTSYVLLAYLTAQPAptsgDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1056
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGGE----DLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
740-1056 |
2.16e-156 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 471.01 E-value: 2.16e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 740 FSVLGDILGSAMQ----NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDG 815
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 816 SYSTFGERygrnQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSA 895
Cdd:pfam07678 81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 896 YVTIALLEI-----PLPVTNPIVRNALFCLESawnvaKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKED 970
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 971 NLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLtaqpapTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVAL 1050
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 1370462546 1051 HALSRY 1056
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
613-700 |
1.16e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.87 E-value: 1.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 613 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 692
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
....*...
gi 1370462546 693 LPKCIRAE 700
Cdd:pfam00207 81 LDKCLKVR 88
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1166-1255 |
2.92e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.45 E-value: 2.92e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1166 PASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTE-VSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDY 1244
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|.
gi 1370462546 1245 YETDESVVAEY 1255
Cdd:pfam07677 81 YEPERRATTFY 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
35-1225 |
1.74e-32 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 137.90 E-value: 1.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 35 LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVVVQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDE 112
Cdd:COG2373 409 LTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGD 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 113 KVNITVCGEYTYGKPVPGL-ATVSLCRKLS-------------RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitN 178
Cdd:COG2373 488 PVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyrfgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--D 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 179 TGFEMKLRVEARIREEGTDlEVTAnriSEITNIVSKLKFVKV----DSHFRQGIPFFAQVLLVDGKGVPIPN-----KLF 249
Cdd:COG2373 566 APGPLRATVEASVFESGGR-PVTR---SATVPVHPADFYVGIrlplFDGDPEGAPATFEVVAVDPDGKPVAGkglkvELY 641
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 250 --------FISVNDANYYSNATTNEQgLAQFSINTTSISVNKlfVRVFTVHPNlcfHYSWVAEDHQGaQHTANRVFSLSG 321
Cdd:COG2373 642 reewryvwYKSDDGGWRYESQEKEEP-VAEGTLTTGADGPAS--LSLTPVEWG---RYRLEVKDPDG-GLATSVRFYAGG 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 322 SYIHLEPVAGTLpcghteTITahytLNRQ--AMGELSELSF------HYLIMakgvIVRSG---THTLPVEsgdmKGSFA 390
Cdd:COG2373 715 NASWGAERPDRL------ELS----LDKEsyKPGETAKLLIqspfagRALVT----VERDGvleTQWVDVK----GGGTT 776
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 391 LSFPVESDVAP-------------------IARMFIFAILPdgevVGDSEKfeienclANKVDLSfSPAQSPPASHAHLQ 451
Cdd:COG2373 777 VEIPVTEDWAPnayvsatlvrpgdstandmPARAYGVAPLP----VDPPAR-------RLKVELT-APEKLRPGETLTVT 844
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 452 V----AAAPQSLCALRAVDQSVLlmkpeaelsvssvynlltvkDLTNF--PDnvdqqeeeqghcPRPFFIHNGAIYVPLS 525
Cdd:COG2373 845 VkvkgAAGKAAEVTLAAVDEGIL--------------------NLTGYktPD------------PLDFFYGKRALGVETR 892
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 526 sneaDIYSFLkgMGLKVFTNSKIRKpkscsvipsvsaGAVGqgyyGAGLGVVERPyvpqlgtynviplnneqssgpvpet 605
Cdd:COG2373 893 ----DLYGRL--IGAFGGAAGALRS------------GGDG----ALGRGGNPKP------------------------- 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 606 VRSYFPETWIWE-LVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEVFT 684
Cdd:COG2373 926 PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFE 1003
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 685 LKATVLNYLPKC------IRAEGI-----EQEKTFS-----------------------SMTCASG-------------- 716
Cdd:COG2373 1004 LPVDVFNLTGKAgtvtvtLEASGGltlegEATQTVTlaaggratvrfplkapdagdakvTVTATGGgesdarevelpvrp 1083
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 717 --------------ANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNyL 782
Cdd:COG2373 1084 anplvtratsgvlaPGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-L 1162
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 783 NETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARSY-IFIDEAHITQSLTW 861
Cdd:COG2373 1163 AEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDY 1239
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 862 LSQMQKDNGcfrssgsllnnAIKGGVEDEATLSAYVTIALLEIPLPVTNPivrnalfcLESAWNVAKEGTHGshvYTKAL 941
Cdd:COG2373 1240 LRNYLRNPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGD--------LRYLYDRRKDALSP---LAKAQ 1297
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 942 LAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWerpqrpkapvGHLYQTqapsaEVEMTSYVLLAYLTAQPAPTSgdlt 1021
Cdd:COG2373 1298 LAAALALLGDKARAEELLAAALARLRETGARDYW----------YGDYGS-----PLRDQALALALLAELGPDAPL---- 1358
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1022 sATNIVKWIMKQQNaQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDsqtfsTNFQVDNNNLLLLQQISLPEL- 1100
Cdd:COG2373 1359 -APKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRGPLARVTLPAAELl 1431
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1101 PGEYVITVTGERCVYLQTSMKYNILPEKE---DSPFALKVQ---TVPQTCDGHKAH--TSFQISLTISyTGNRPASNMVI 1172
Cdd:COG2373 1432 AGPLTITNTGDGPLYYTLTLSGYPAEGPPpaaSNGLEIERRyydLDGKPIDPASLKqgDLVVVRLTVT-APSGRVENVAV 1510
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370462546 1173 VDvkMV-SGFIPLKP-------TVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMV 1225
Cdd:COG2373 1511 VD--PLpAGFEIENPrlatsgdLGDWLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLV 1569
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
324-472 |
3.03e-31 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 119.76 E-value: 3.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 324 IHLEPVAGTLPCGHTETITAHYTLNRQAMGElselSFHYLIMAKGVIVRSGthtlpvesgDMKGSFALSFPVESDVAPIA 403
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVG---------RGGVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370462546 404 RMFIFAI---LPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLM 472
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
750-1056 |
4.03e-166 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 495.56 E-value: 4.03e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 750 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGrnQG 829
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 830 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 909
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 910 NPIVRNALFCLESAWNVAkegthgSHVYTKALLAYAFSLLGkQNQNREILNSLDKEAVKEDNLVHWERPqrPKAPVGHLY 989
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370462546 990 QTQAPSAEVEMTSYVLLAYLTAQPAptsgDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1056
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGGE----DLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
740-1056 |
2.16e-156 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 471.01 E-value: 2.16e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 740 FSVLGDILGSAMQ----NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDG 815
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 816 SYSTFGERygrnQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSA 895
Cdd:pfam07678 81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 896 YVTIALLEI-----PLPVTNPIVRNALFCLESawnvaKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKED 970
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 971 NLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLtaqpapTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVAL 1050
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 1370462546 1051 HALSRY 1056
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
750-1056 |
2.46e-115 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 360.94 E-value: 2.46e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 750 AMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGeryGRNQG 829
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWG---NSDSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 830 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVT 909
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKACD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 910 NPIvRNALFCLESAWNVAKegthgsHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERpqrpkapvgHLY 989
Cdd:cd02891 158 ASI-EKALAYLETQLDGLL------DPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSL---------SWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370462546 990 QTQAPSAEVEMTSYVLLAYLTAqpaptsGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1056
Cdd:cd02891 222 GDYGSSLRVEATAYALLALLKL------GDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
753-1056 |
1.13e-77 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 258.36 E-value: 1.13e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 753 NIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQ---EIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERygrnQG 829
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQWEKlgpERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNR----PS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 830 NTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGV---EDEATLSAYVTIALLEIpL 906
Cdd:cd02896 80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEA-R 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 907 PVTNPIVRNalfcLESAWNVAKE-----GTHGSHVYTKALLAYAFSLLGKqNQNREILNSLDKEAVKEDNLVHWERPQRP 981
Cdd:cd02896 159 SICPPEVQN----LDQSIRKAISylenqLPNLQRPYALAITAYALALADS-PLSHAANRKLLSLAKRDGNGWYWWTIDSP 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370462546 982 kapvgHLYQTQAPSAEVEMTSYVLLAYLtaqpapTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRY 1056
Cdd:cd02896 234 -----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
750-1056 |
6.56e-69 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 233.98 E-value: 6.56e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 750 AMQNIQNLLQMPYG--------CGEQNMVLFAPNIYVLNYLNETqqltqEIKAKAVGYLITGYQRQLNYKHQDGSYSTFG 821
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAAT-----GIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 822 eryGRNQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNaiKGGVEDEATLSAYVTIAL 901
Cdd:cd00688 76 ---GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 902 LEIPLPVTNPIVRNALFCLESAWNvaKEGTHG----SHVYTKALLAYAFSLLGKQNQN--REILNSLDKEAVKEDNLVHW 975
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLSCQN--YDGGFGpggeSHGYGTACAAAALALLGDLDSPdaKKALRWLLSRQRPDGGWGEG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 976 ERpqrpkapvghLYQTQAPSAEVEMTSYVLLAYLTAqpaptsGDLTSATNIVKWIMKQQNAQGGFSS-------TQDTVV 1048
Cdd:cd00688 229 RD----------RTNKLSDSCYTEWAAYALLALGKL------GDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVF 292
|
....*...
gi 1370462546 1049 ALHALSRY 1056
Cdd:cd00688 293 ALLALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
613-700 |
1.16e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.87 E-value: 1.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 613 TWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNY 692
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
....*...
gi 1370462546 693 LPKCIRAE 700
Cdd:pfam00207 81 LDKCLKVR 88
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1166-1255 |
2.92e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 123.45 E-value: 2.92e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1166 PASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTE-VSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDY 1244
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|.
gi 1370462546 1245 YETDESVVAEY 1255
Cdd:pfam07677 81 YEPERRATTFY 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
35-1225 |
1.74e-32 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 137.90 E-value: 1.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 35 LENPRRNRIAQwQSLKL-EAGINQLSFPLSSEPIQGSYRVVVQTESGGRI-QHPFTVEEFVLPKFEVKVQVPKIISIMDE 112
Cdd:COG2373 409 LTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLELYVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGD 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 113 KVNITVCGEYTYGKPVPGL-ATVSLCRKLS-------------RVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQitN 178
Cdd:COG2373 488 PVTVTVDARYLFGAPAAGLkVEGEVTLRPArtafpgypgyrfgDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAP--D 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 179 TGFEMKLRVEARIREEGTDlEVTAnriSEITNIVSKLKFVKV----DSHFRQGIPFFAQVLLVDGKGVPIPN-----KLF 249
Cdd:COG2373 566 APGPLRATVEASVFESGGR-PVTR---SATVPVHPADFYVGIrlplFDGDPEGAPATFEVVAVDPDGKPVAGkglkvELY 641
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 250 --------FISVNDANYYSNATTNEQgLAQFSINTTSISVNKlfVRVFTVHPNlcfHYSWVAEDHQGaQHTANRVFSLSG 321
Cdd:COG2373 642 reewryvwYKSDDGGWRYESQEKEEP-VAEGTLTTGADGPAS--LSLTPVEWG---RYRLEVKDPDG-GLATSVRFYAGG 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 322 SYIHLEPVAGTLpcghteTITahytLNRQ--AMGELSELSF------HYLIMakgvIVRSG---THTLPVEsgdmKGSFA 390
Cdd:COG2373 715 NASWGAERPDRL------ELS----LDKEsyKPGETAKLLIqspfagRALVT----VERDGvleTQWVDVK----GGGTT 776
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 391 LSFPVESDVAP-------------------IARMFIFAILPdgevVGDSEKfeienclANKVDLSfSPAQSPPASHAHLQ 451
Cdd:COG2373 777 VEIPVTEDWAPnayvsatlvrpgdstandmPARAYGVAPLP----VDPPAR-------RLKVELT-APEKLRPGETLTVT 844
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 452 V----AAAPQSLCALRAVDQSVLlmkpeaelsvssvynlltvkDLTNF--PDnvdqqeeeqghcPRPFFIHNGAIYVPLS 525
Cdd:COG2373 845 VkvkgAAGKAAEVTLAAVDEGIL--------------------NLTGYktPD------------PLDFFYGKRALGVETR 892
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 526 sneaDIYSFLkgMGLKVFTNSKIRKpkscsvipsvsaGAVGqgyyGAGLGVVERPyvpqlgtynviplnneqssgpvpet 605
Cdd:COG2373 893 ----DLYGRL--IGAFGGAAGALRS------------GGDG----ALGRGGNPKP------------------------- 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 606 VRSYFPETWIWE-LVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEVFT 684
Cdd:COG2373 926 PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFE 1003
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 685 LKATVLNYLPKC------IRAEGI-----EQEKTFS-----------------------SMTCASG-------------- 716
Cdd:COG2373 1004 LPVDVFNLTGKAgtvtvtLEASGGltlegEATQTVTlaaggratvrfplkapdagdakvTVTATGGgesdarevelpvrp 1083
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 717 --------------ANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNyL 782
Cdd:COG2373 1084 anplvtratsgvlaPGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-L 1162
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 783 NETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARSY-IFIDEAHITQSLTW 861
Cdd:COG2373 1163 AEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDY 1239
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 862 LSQMQKDNGcfrssgsllnnAIKGGVEDEATLSAYVTIALLEIPLPVTNPivrnalfcLESAWNVAKEGTHGshvYTKAL 941
Cdd:COG2373 1240 LRNYLRNPW-----------EIEYDDAYRLAVRAYALYVLARAGKADLGD--------LRYLYDRRKDALSP---LAKAQ 1297
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 942 LAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWerpqrpkapvGHLYQTqapsaEVEMTSYVLLAYLTAQPAPTSgdlt 1021
Cdd:COG2373 1298 LAAALALLGDKARAEELLAAALARLRETGARDYW----------YGDYGS-----PLRDQALALALLAELGPDAPL---- 1358
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1022 sATNIVKWIMKQQNaQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDsqtfsTNFQVDNNNLLLLQQISLPEL- 1100
Cdd:COG2373 1359 -APKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTLDG-----KTLPLTGRGPLARVTLPAAELl 1431
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 1101 PGEYVITVTGERCVYLQTSMKYNILPEKE---DSPFALKVQ---TVPQTCDGHKAH--TSFQISLTISyTGNRPASNMVI 1172
Cdd:COG2373 1432 AGPLTITNTGDGPLYYTLTLSGYPAEGPPpaaSNGLEIERRyydLDGKPIDPASLKqgDLVVVRLTVT-APSGRVENVAV 1510
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370462546 1173 VDvkMV-SGFIPLKP-------TVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMV 1225
Cdd:COG2373 1511 VD--PLpAGFEIENPrlatsgdLGDWLGDSWQPDHQEFRDDRVVAAFDLDPAGTYTFAYLV 1569
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
324-472 |
3.03e-31 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 119.76 E-value: 3.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 324 IHLEPVAGTLPCGHTETITAHYTLNRQAMGElselSFHYLIMAKGVIVRSGthtlpvesgDMKGSFALSFPVESDVAPIA 403
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVG---------RGGVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370462546 404 RMFIFAI---LPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLM 472
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
215-310 |
2.02e-29 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 112.73 E-value: 2.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 215 LKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSiSVNKLFVRVFTVHPN 294
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 1370462546 295 LCFHYSWVAEDHQGAQ 310
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
91-178 |
3.76e-28 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 108.90 E-value: 3.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462546 91 EFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSrvlncDKQEVCEEFSQQLNSNGCITQQVH 170
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD-----SKRKCFESFSKELDKDGCGSASLS 75
|
....*...
gi 1370462546 171 TKMLQITN 178
Cdd:pfam17791 76 TEEFQLTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
12-89 |
2.41e-14 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 69.65 E-value: 2.41e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370462546 12 VRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQTESGGRI-QHPFTV 89
Cdd:pfam01835 17 VHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLRDGAGGSLgSGSFRV 95
|
|
| |
