NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1343946092|ref|XP_023809546|]
View 

katanin p80 WD40 repeat-containing subunit B1 [Oryzias latipes]

Protein Classification

WD repeat KATNB1 family protein( domain architecture ID 10078096)

WD repeat KATNB1 family protein similar to Mus musculus katanin p80 WD40 repeat-containing subunit B1 (KATNB1) that participates in a complex which severs microtubules in an ATP-dependent manner

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-262 2.66e-79

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 258.30  E-value: 2.66e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:COG2319   155 LRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD 252
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                         250
                  ....*....|.
gi 1343946092 253 -SLRVfgWEPD 262
Cdd:COG2319   394 gTVRL--WDLA 402
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 522-680 1.09e-57

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 192.44  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 522 KGHDTMMLILSSRLKNLQTVSAVWTRDGSKEALETAVSMKDLSIVVDILNKINLQPSLWSLDACTLLLPQVHKLLQSKYE 601
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 602 SYIQTGSTSLKLIMRHFWALISETLKALP-SVGVDITREERHRKCQQCCKLLKTTSVTVKSRAPQVGRLGSTFLELQLVL 680
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 309-510 6.10e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 6.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  309 GKSAPYRVAPDDQ-PDPEKKDPGGAALRRSYERPPTTCSAQRVKQRSESERRSPdgERRSPSEDEADEKVLSAEIHNAED 387
Cdd:PHA03247  2610 GPAPPSPLPPDTHaPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR--PRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  388 FREIFQPKNAISRTPPRMTEPFPAPPddGESDTIVAVSRQLKDGSCFPTKLQTPAlATSTPVQRVEPTVVSSGKRPA--A 465
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPH--ALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGPATPGGPARPARPPttA 2764

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1343946092  466 GPACQPPPQNPVEPKPRIIPSSRNEPIGLNVDDFLSGSDDSSAAA 510
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA 2809
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-262 2.66e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 258.30  E-value: 2.66e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:COG2319   155 LRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD 252
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                         250
                  ....*....|.
gi 1343946092 253 -SLRVfgWEPD 262
Cdd:COG2319   394 gTVRL--WDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-257 1.31e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 247.25  E-value: 1.31e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:cd00200    44 LRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD 252
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*.
gi 1343946092 253 -SLRVF 257
Cdd:cd00200   283 gTIRIW 288
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 522-680 1.09e-57

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 192.44  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 522 KGHDTMMLILSSRLKNLQTVSAVWTRDGSKEALETAVSMKDLSIVVDILNKINLQPSLWSLDACTLLLPQVHKLLQSKYE 601
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 602 SYIQTGSTSLKLIMRHFWALISETLKALP-SVGVDITREERHRKCQQCCKLLKTTSVTVKSRAPQVGRLGSTFLELQLVL 680
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 pfam00400
WD domain, G-beta repeat;
140-175 3.32e-12

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 61.21  E-value: 3.32e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1343946092 140 VFRFKGHTDAVRSLAFSPDGKWLASASDDCTVKLWD 175
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-175 3.82e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.17  E-value: 3.82e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1343946092  140 VFRFKGHTDAVRSLAFSPDGKWLASASDDCTVKLWD 175
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 15-167 1.10e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  15 EFEAHARPVSCLALGKSTGRLLATGGEDCRVNLWSLNKANCIMSLTGhKTAVECIQF-SLSEEQVAAGSQSGSIRVWDLE 93
Cdd:PLN00181  570 EMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR 648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  94 AAKI-LQTLMGHKASITSLGFHPyGQFLASSSMDTNIKLWDVR------RKGYVFRFKGHTDAVRSLAFSPDGKWLASAS 166
Cdd:PLN00181  649 NPKLpLCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGS 727


                  .
gi 1343946092 167 D 167
Cdd:PLN00181  728 E 728
PHA03247 PHA03247
large tegument protein UL36; Provisional
 309-510 6.10e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 6.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  309 GKSAPYRVAPDDQ-PDPEKKDPGGAALRRSYERPPTTCSAQRVKQRSESERRSPdgERRSPSEDEADEKVLSAEIHNAED 387
Cdd:PHA03247  2610 GPAPPSPLPPDTHaPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR--PRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  388 FREIFQPKNAISRTPPRMTEPFPAPPddGESDTIVAVSRQLKDGSCFPTKLQTPAlATSTPVQRVEPTVVSSGKRPA--A 465
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPH--ALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGPATPGGPARPARPPttA 2764

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1343946092  466 GPACQPPPQNPVEPKPRIIPSSRNEPIGLNVDDFLSGSDDSSAAA 510
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA 2809
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-262 2.66e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 258.30  E-value: 2.66e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:COG2319   155 LRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD 252
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                         250
                  ....*....|.
gi 1343946092 253 -SLRVfgWEPD 262
Cdd:COG2319   394 gTVRL--WDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
12-279 1.65e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 253.68  E-value: 1.65e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  12 RLQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWD 91
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  92 LEAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTV 171
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 172 KLWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGAT 251
Cdd:COG2319   271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                         250       260
                  ....*....|....*....|....*....
gi 1343946092 252 D-SLRVFGWEPDRCIDVVRVWWGKVSDLA 279
Cdd:COG2319   351 DgTVRLWDLATGELLRTLTGHTGAVTSVA 379
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-257 1.31e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 247.25  E-value: 1.31e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:cd00200    44 LRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD 252
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*.
gi 1343946092 253 -SLRVF 257
Cdd:cd00200   283 gTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-290 1.32e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 247.25  E-value: 1.32e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:cd00200     2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD 252
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1343946092 253 -SLRVFGWEPDRCIDVVRVWWGKVSDLAVCN--QQLIGASH 290
Cdd:cd00200   241 gTIRVWDLRTGECVQTLSGHTNSVTSLAWSPdgKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
12-280 2.55e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 247.90  E-value: 2.55e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  12 RLQEFEAHARPVSCLALgKSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWD 91
Cdd:COG2319    70 LLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  92 LEAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTV 171
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 172 KLWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGAT 251
Cdd:COG2319   229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                         250       260       270
                  ....*....|....*....|....*....|
gi 1343946092 252 D-SLRVFGWEPDRCIDVVRVWWGKVSDLAV 280
Cdd:COG2319   309 DgTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
12-279 1.61e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 221.71  E-value: 1.61e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  12 RLQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWD 91
Cdd:COG2319    28 LLLLLLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  92 LEAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTV 171
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 172 KLWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGAT 251
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         250       260
                  ....*....|....*....|....*....
gi 1343946092 252 D-SLRVFGWEPDRCIDVVRVWWGKVSDLA 279
Cdd:COG2319   267 DgTVRLWDLATGELLRTLTGHSGGVNSVA 295
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-217 2.58e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.11  E-value: 2.58e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  13 LQEFEAHARPVSCLALgKSTGRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDL 92
Cdd:cd00200    86 VRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  93 EAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVK 172
Cdd:cd00200   165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1343946092 173 LWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWD 217
Cdd:cd00200   245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 522-680 1.09e-57

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 192.44  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 522 KGHDTMMLILSSRLKNLQTVSAVWTRDGSKEALETAVSMKDLSIVVDILNKINLQPSLWSLDACTLLLPQVHKLLQSKYE 601
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 602 SYIQTGSTSLKLIMRHFWALISETLKALP-SVGVDITREERHRKCQQCCKLLKTTSVTVKSRAPQVGRLGSTFLELQLVL 680
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSAPPsSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 COG2319
WD40 repeat [General function prediction only];
33-280 5.05e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.98  E-value: 5.05e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  33 GRLLATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDLEAAKILQTLMGHKASITSLG 112
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 113 FHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKSHSAAV 192
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 193 NIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD-SLRVFGWEPDRCIDVVRVW 271
Cdd:COG2319   166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKLLRTLTGH 245


                  ....*....
gi 1343946092 272 WGKVSDLAV 280
Cdd:COG2319   246 SGSVRSVAF 254
WD40 COG2319
WD40 repeat [General function prediction only];
70-289 2.95e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 2.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  70 QFSLSEEQVAAGSQSGSIRVWDLEAAKILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDA 149
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 150 VRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEG 229
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343946092 230 DTSAIRCVCFSPDGSCLFSGATD-SLRVFGWEPDRCIDVVRVWWGKVSDLAVC--NQQLIGAS 289
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGS 223
WD40 pfam00400
WD domain, G-beta repeat;
140-175 3.32e-12

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 61.21  E-value: 3.32e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1343946092 140 VFRFKGHTDAVRSLAFSPDGKWLASASDDCTVKLWD 175
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-175 3.82e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.17  E-value: 3.82e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1343946092  140 VFRFKGHTDAVRSLAFSPDGKWLASASDDCTVKLWD 175
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 15-167 1.10e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  15 EFEAHARPVSCLALGKSTGRLLATGGEDCRVNLWSLNKANCIMSLTGhKTAVECIQF-SLSEEQVAAGSQSGSIRVWDLE 93
Cdd:PLN00181  570 EMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLR 648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  94 AAKI-LQTLMGHKASITSLGFHPyGQFLASSSMDTNIKLWDVR------RKGYVFRFKGHTDAVRSLAFSPDGKWLASAS 166
Cdd:PLN00181  649 NPKLpLCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGS 727


                  .
gi 1343946092 167 D 167
Cdd:PLN00181  728 E 728
PTZ00421 PTZ00421
coronin; Provisional
 82-220 9.60e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.45  E-value: 9.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  82 SQSGSIRVWDLEAAKILQT-------LMGHKASITSLGFHPYGQ-FLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSL 153
Cdd:PTZ00421   95 SEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSL 174

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1343946092 154 AFSPDGKWLASASDDCTVKLWDLSQGKIITEFKSHSAAVN--IVQFHPNEYLLASG---SSDRSVRLWDLEK 220
Cdd:PTZ00421  175 EWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcskSQQRQIMLWDTRK 246
PTZ00420 PTZ00420
coronin; Provisional
 129-219 1.27e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.12  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 129 IKLWDVRRKGYVFRFKGHTDAVRSLAFSP-DGKWLASASDDCTVKLWDLSQG----KIITE----FKSHSAAVNIVQFHP 199
Cdd:PTZ00420   56 IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNdesvKEIKDpqciLKGHKKKISIIDWNP 135

                          90       100
                  ....*....|....*....|.
gi 1343946092 200 -NEYLLASGSSDRSVRLWDLE 219
Cdd:PTZ00420  136 mNYYIMCSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 1.56e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1343946092  178 QGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 36-213 1.87e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.87  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  36 LATGGEDCRVNLWSLNKANCIMSLTGHKTAVECIQFSLSEEQV-AAGSQSGSIRVWDLEAAKILQTLMGhKASITSLGF- 113
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLlASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFp 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 114 HPYGQFLASSSMDTNIKLWDVRR-KGYVFRFKGHTDAVRSLAFSpDGKWLASASDDCTVKLWDLSQG------KIITEFK 186
Cdd:PLN00181  627 SESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFM 705

                         170       180
                  ....*....|....*....|....*..
gi 1343946092 187 SHSAAVNIVQFHPNEYLLASGSSDRSV 213
Cdd:PLN00181  706 GHTNVKNFVGLSVSDGYIATGSETNEV 732
WD40 pfam00400
WD domain, G-beta repeat;
96-133 2.44e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 2.44e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1343946092  96 KILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 101-237 3.30e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.91  E-value: 3.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 101 LMGHKASITSLGFHPY-GQFLASSSMDTNIKLWDVRRKG-------YVFRFKGHTDAVRSLAFSPDGK-WLASASDDCTV 171
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPFdPQKLFTASEDGTIMGWGIPEEGltqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVV 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343946092 172 KLWDLSQGKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSA--IRCV 237
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksQRCL 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-133 3.62e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 3.62e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1343946092   96 KILQTLMGHKASITSLGFHPYGQFLASSSMDTNIKLWD 133
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 33-218 6.91e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  33 GRLLATGGEDCRVNLWSLNKA--------NCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWDLEAAKILQTLMGH 104
Cdd:PLN00181  495 GEFFATAGVNKKIKIFECESIikdgrdihYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 105 KASITSLGFHPYG-QFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFSPDGKWLASASDDCTVKLWDLSQGKI-I 182
Cdd:PLN00181  575 EKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLpL 654

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1343946092 183 TEFKSHSAAVNIVQFHPNEYLLASgSSDRSVRLWDL 218
Cdd:PLN00181  655 CTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-252 8.48e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 8.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 108 ITSLGFHPYGQFLASSSMDTNIKLW-------DVRRKGY-VFRFKGHTDaVRSLAFSPDGK-WLASASDDCTVKLWDLSQ 178
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYpVVELASRSK-LSGICWNSYIKsQVASSNFEGVVQVWDVAR 564

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343946092 179 GKIITEFKSHSAAVNIVQFHP-NEYLLASGSSDRSVRLWDLEKFTMIGTLEGDTSaIRCVCFSPD-GSCLFSGATD 252
Cdd:PLN00181  565 SQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSAD 639
WD40 pfam00400
WD domain, G-beta repeat;
179-217 2.53e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1343946092 179 GKIITEFKSHSAAVNIVQFHPNEYLLASGSSDRSVRLWD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 56-222 3.51e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 56.50  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  56 IMSLTGHKTAVECIQFS-LSEEQVAAGSQSGSIRVWDL--------EAAKILQTLMGHKASITSLGFHPYGQF-LASSSM 125
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYiMCSSGF 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 126 DTNIKLWDVRRKGYVFRFKgHTDAVRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKSHSAAVN-----IVQFHPN 200
Cdd:PTZ00420  147 DSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNtkniwIDGLGGD 225

                         170       180
                  ....*....|....*....|....*.
gi 1343946092 201 E-YLLASGSSD---RSVRLWDLEKFT 222
Cdd:PTZ00420  226 DnYILSTGFSKnnmREMKLWDLKNTT 251
PTZ00421 PTZ00421
coronin; Provisional
 145-280 5.61e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 5.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 145 GHTDAVRSLAFSP-DGKWLASASDDCTVKLWDLSQGKI-------ITEFKSHSAAVNIVQFHPNEY-LLASGSSDRSVRL 215
Cdd:PTZ00421   73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343946092 216 WDLEKFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD-SLRVFgwEPDRCiDVV------------RVWWGKVSDLAV 280
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDkKLNII--DPRDG-TIVssveahasaksqRCLWAKRKDLII 227
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-91 8.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 8.82e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1343946092   54 NCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWD 91
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
54-91 3.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1343946092  54 NCIMSLTGHKTAVECIQFSLSEEQVAAGSQSGSIRVWD 91
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 139-193 4.94e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.35  E-value: 4.94e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343946092 139 YVFRFKGH----------TDAVRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKSHSAAVN 193
Cdd:pfam12894  20 LLHRLNWQrvwtlspdkeDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLIT 84
PHA03247 PHA03247
large tegument protein UL36; Provisional
 309-510 6.10e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 6.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  309 GKSAPYRVAPDDQ-PDPEKKDPGGAALRRSYERPPTTCSAQRVKQRSESERRSPdgERRSPSEDEADEKVLSAEIHNAED 387
Cdd:PHA03247  2610 GPAPPSPLPPDTHaPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR--PRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  388 FREIFQPKNAISRTPPRMTEPFPAPPddGESDTIVAVSRQLKDGSCFPTKLQTPAlATSTPVQRVEPTVVSSGKRPA--A 465
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPH--ALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGPATPGGPARPARPPttA 2764

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1343946092  466 GPACQPPPQNPVEPKPRIIPSSRNEPIGLNVDDFLSGSDDSSAAA 510
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA 2809
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-257 5.61e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.61e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1343946092  220 KFTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD-SLRVF 257
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLW 39
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 317-515 8.67e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 8.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  317 APDDQPDPEKKDPGG--AALRRSYERPPTTCSAQRVKQRSESERRSP-DGERRSPSEDEADEKVLSAEIHNAEDFREIFQ 393
Cdd:PHA03307    60 AACDRFEPPTGPPPGpgTEAPANESRSTPTWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  394 PKNAISRTPPRMTEPFPAPPDDGESDTivAVSRQlkdgscfptklqtPALATSTPVQRVEPTVVSSGKRPAAGPACQPPP 473
Cdd:PHA03307   140 PVGSPGPPPAASPPAAGASPAAVASDA--ASSRQ-------------AALPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1343946092  474 QNPVEPKPRIIPSSRNEPIGLNVDDFLSGSDDSSAAALSDEE 515
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSG 246
WD40 pfam00400
WD domain, G-beta repeat;
221-257 1.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1343946092 221 FTMIGTLEGDTSAIRCVCFSPDGSCLFSGATD-SLRVF 257
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVW 38
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
107-263 2.62e-04

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 44.10  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 107 SITSLGFHPYGQFLASSSMdTNIKLWDVRRKGYVFRFKgHTDaVRSLAFSPDGKWLASASD---------------DCTV 171
Cdd:COG5354    34 PVAYVSESPLGTYLFSEHA-AGVECWGGPSKAKLVRFR-HPD-VKYLDFSPNEKYLVTWSRepiiepeieispftsKNNV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 172 KLWDLSQGKIITEFKSHSAAV---NIVQFHPNEYLLASGSSDrSVRLWDLEKFTMigtlEGDTSAIRCVCFSpdgSCLFS 248
Cdd:COG5354   111 FVWDIASGMIVFSFNGISQPYlgwPVLKFSIDDKYVARVVGS-SLYIHEITDNIE----EHPFKNLRPVGIL---DFSIS 182

                         170
                  ....*....|....*
gi 1343946092 249 GATDSLRVFGWEPDR 263
Cdd:COG5354   183 PEGNHDELAYWTPEK 197
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
79-247 2.67e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  79 AAGSQSGSIRVWDLEAAKILQTLmghkasitSLGFHPYGqflasssmdtniklwdvrrkgyvfrfkghtdavrsLAFSPD 158
Cdd:COG3391    84 VANSGSGRVSVIDLATGKVVATI--------PVGGGPRG-----------------------------------LAVDPD 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 159 GKWL-ASASDDCTVKLWDLSQGKIITEFKSHSAAVNIVqFHP-NEYLLASGSSDRS----VRLWDLEKFTMIGTLEGDTS 232
Cdd:COG3391   121 GGRLyVADSGNGRVSVIDTATGKVVATIPVGAGPHGIA-VDPdGKRLYVANSGSNTvsviVSVIDTATGKVVATIPVGGG 199

                         170
                  ....*....|....*
gi 1343946092 233 AIRcVCFSPDGSCLF 247
Cdd:COG3391   200 PVG-VAVSPDGRRLY 213
WD40 pfam00400
WD domain, G-beta repeat;
13-49 5.62e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 5.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1343946092  13 LQEFEAHARPVSCLALgKSTGRLLATGGEDCRVNLWS 49
Cdd:pfam00400   4 LKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
PHA03378 PHA03378
EBNA-3B; Provisional
 338-521 6.04e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 6.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 338 YERPPTTCSAQRVKQRSESERRSPDgerRSPSEDEADEKVLSAEIHNAEDFREIFQPKNAISRTPPRMTEPFPAPPDDGe 417
Cdd:PHA03378  674 YQPSPTGANTMLPIQWAPGTMQPPP---RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAA- 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 418 sdTIVAVSRQLKDGSCFPTKLQTPALATSTPVQRVEPTvvsSGKRPAAGPACQPPPQNPvePKPRII----PSSRNEPIG 493
Cdd:PHA03378  750 --APGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPA---PQQRPRGAPTPQPPPQAG--PTSMQLmpraAPGQQGPTK 822

                         170       180
                  ....*....|....*....|....*...
gi 1343946092 494 LNVDDFLSGSDDSSAAALSDEEVLAQIR 521
Cdd:PHA03378  823 QILRQLLTGGVKRGRPSLKKPAALERQA 850
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 150-259 1.08e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 42.33  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  150 VRSLAFSPDGKWLASASDDCTVKLWDLSQGKIITEFKSHSAAVNI-VQFHP-NEYLLASGSSD---RSVRLWDLEKFTMI 224
Cdd:COG4946    391 VFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDGYGDGISdLAWSPdSKWLAYSKPGPnqlSQIFLYDVETGKTV 470

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1343946092  225 GTLEGDTSAIRCVcFSPDGSCL-FSGATDSLRVFGW 259
Cdd:COG4946    471 QLTDGRYDDGSPA-FSPDGKYLyFLSSRDFNPTYGD 505
PHA03247 PHA03247
large tegument protein UL36; Provisional
 311-500 1.24e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  311 SAPYRVAPDDQPDPEKKDPGGAALRRSYERP----PTTCSAQRVKQRSESERRSP------------DGERRSPSEDEAD 374
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPagplPPPTSAQPTAPPPPPGPPPPslplggsvapggDVRRRPPSRSPAA 2873

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  375 EKVLSAEIHnaedFREIFQPKnaisrtPPRMTEPFPAPPDDgesdtivavsrqlkdgscfPTKLQTPALATSTPVQRVEP 454
Cdd:PHA03247  2874 KPAAPARPP----VRRLARPA------VSRSTESFALPPDQ-------------------PERPPQPQAPPPPQPQPQPP 2924

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1343946092  455 tvvssgKRPAAGPACQPPPQNPVEPKPRIIPSSRNEPIGLNVDDFL 500
Cdd:PHA03247  2925 ------PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 13-49 1.62e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1343946092   13 LQEFEAHARPVSCLALGkSTGRLLATGGEDCRVNLWS 49
Cdd:smart00320   5 LKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 78-156 3.03e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092  78 VAAGSQSGSIRVWDLEAAKILQT-LMGHKASITSLGFHPYGQFLASSSMDTNIKLWDVRRKGYVFRFKGHTDAVRSLAFS 156
Cdd:pfam12894  10 IALATEDGELLLHRLNWQRVWTLsPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-289 3.11e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 3.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343946092 223 MIGTLEGDTSAIRCVCFSPDGSCLFSGATD-SLRVFGWEPDRCIDVVRVWWGKVSDLAVC--NQQLIGAS 289
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGS 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH