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Conserved domains on  [gi|2078402340|ref|XP_023763698|]
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caffeoylshikimate esterase [Lactuca sativa]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 8-294 6.89e-110

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02385:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 349  Bit Score: 323.24  E-value: 6.89e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   8 VKYEEEFITNSKGVKLFTCRWLPVDCEPKALVFLNHGYAMECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPS 87
Cdd:PLN02385   59 IKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  88 FSDMVDDSSDFFTSVCEKQENKNKLRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLSDDMKPPQIVVSILSHLTR 167
Cdd:PLN02385  139 FDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLAN 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 168 IIPTWRIVPGQDIIELAFRDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTAS 247
Cdd:PLN02385  219 LLPKAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVS 298

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2078402340 248 KLLYEKASSTDKTFKLYPGMWHALTYGEFTENTDIVFADIITWINER 294
Cdd:PLN02385  299 KFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSH 345
 
Name Accession Description Interval E-value
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 8-294 6.89e-110

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 323.24  E-value: 6.89e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   8 VKYEEEFITNSKGVKLFTCRWLPVDCEPKALVFLNHGYAMECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPS 87
Cdd:PLN02385   59 IKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  88 FSDMVDDSSDFFTSVCEKQENKNKLRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLSDDMKPPQIVVSILSHLTR 167
Cdd:PLN02385  139 FDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLAN 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 168 IIPTWRIVPGQDIIELAFRDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTAS 247
Cdd:PLN02385  219 LLPKAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVS 298

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2078402340 248 KLLYEKASSTDKTFKLYPGMWHALTYGEFTENTDIVFADIITWINER 294
Cdd:PLN02385  299 KFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSH 345
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 34-271 1.98e-73

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 226.33  E-value: 1.98e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  34 EPKALVFLNHGYAmECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPSFSDMVDDSSDFFTSVceKQENKNKLR 113
Cdd:pfam12146   2 EPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKI--REEHPGLPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 114 VLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLsDDMKPPQIVVSILSHLTRIIPTWRiVPGQDIIELAFRDPKIREE 193
Cdd:pfam12146  79 FLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-KPYLAPPILKLLAKLLGKLFPRLR-VPNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2078402340 194 VRKNPLCyKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLYEKASSTDKTFKLYPGMWHAL 271
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHEL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
9-293 1.68e-34

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 125.11  E-value: 1.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   9 KYEEEFITNSKGVKLFTCRWLPVDcEPKALVFLNHGYAmECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPSF 88
Cdd:COG2267     2 TRRLVTLPTRDGLRLRGRRWRPAG-SPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  89 SDMVDDSSDFFTSVCEKQENKnklRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPmcklsddmkppqivvsilshltri 168
Cdd:COG2267    80 DDYVDDLRAALDALRARPGLP---VVLLGHSMGGLIALLYAARYPDRVAGLVLLAP------------------------ 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 169 iptwrivpgqdiielafrdpkireEVRKNPLCYkgrVRLQTANELFgvttnLETRLQEVKLPFFLAHGGDDKVTDPTASK 248
Cdd:COG2267   133 ------------------------AYRADPLLG---PSARWLRALR-----LAEALARIDVPVLVLHGGADRVVPPEAAR 180

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2078402340 249 LLYEKAsSTDKTFKLYPGMWHALTygeFTENTDIVFADIITWINE 293
Cdd:COG2267   181 RLAARL-SPDVELVLLPGARHELL---NEPAREEVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 59-291 6.36e-13

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 68.27  E-value: 6.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  59 RLVKARFGVYGIDCQGHGKSDG---VLGYIPSFSDMVDDSSDFF-----TSVCEK----------QENKNKLRV---LLG 117
Cdd:TIGR01607  69 NFNKNGYSVYGLDLQGHGESDGlqnLRGHINCFDDLVYDVIQYMnrindSIILENetksddesydIVNTKENRLpmyIIG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 118 ESMGGAMVLR---LHMKKPEFWD-----GGVLVAPMCKLS-----DDMKPPQIVVSILSHLTRIIPTWRIVPGqdiieLA 184
Cdd:TIGR01607 149 LSMGGNIALRlleLLGKSNENNDklnikGCISLSGMISIKsvgsdDSFKFKYFYLPVMNFMSRVFPTFRISKK-----IR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 185 F-RDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEV--KLPFFLAHGGDDKVTDPTASKLLYEKASSTDKTF 261
Cdd:TIGR01607 224 YeKSPYVNDIIKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKEL 303

                         250       260       270
                  ....*....|....*....|....*....|
gi 2078402340 262 KLYPGMWHALTYGEFTENtdiVFADIITWI 291
Cdd:TIGR01607 304 HTLEDMDHVITIEPGNEE---VLKKIIEWI 330
 
Name Accession Description Interval E-value
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 8-294 6.89e-110

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 323.24  E-value: 6.89e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   8 VKYEEEFITNSKGVKLFTCRWLPVDCEPKALVFLNHGYAMECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPS 87
Cdd:PLN02385   59 IKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  88 FSDMVDDSSDFFTSVCEKQENKNKLRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLSDDMKPPQIVVSILSHLTR 167
Cdd:PLN02385  139 FDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILILLAN 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 168 IIPTWRIVPGQDIIELAFRDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTAS 247
Cdd:PLN02385  219 LLPKAKLVPQKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVS 298

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2078402340 248 KLLYEKASSTDKTFKLYPGMWHALTYGEFTENTDIVFADIITWINER 294
Cdd:PLN02385  299 KFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSH 345
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 7-297 5.00e-101

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 299.77  E-value: 5.00e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   7 NVKYEEEFITNSKGVKLFTCRWLPVDCE-PKALVFLNHGYAMECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYI 85
Cdd:PLN02298   29 GIKGSKSFFTSPRGLSLFTRSWLPSSSSpPRALIFMVHGYGNDISWTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAYV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  86 PSFSDMVDDSSDFFTSVCEKQENKNKLRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLSDDMKPPQIVVSILSHL 165
Cdd:PLN02298  109 PNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRPPWPIPQILTFV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 166 TRIIPTWRIVPGQDIIELAFRDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPT 245
Cdd:PLN02298  189 ARFLPTLAIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPD 268

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2078402340 246 ASKLLYEKASSTDKTFKLYPGMWHALTYGEFTENTDIVFADIITWINERIAQ 297
Cdd:PLN02298  269 VSRALYEEAKSEDKTIKIYDGMMHSLLFGEPDENIEIVRRDILSWLNERCTG 320
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 34-271 1.98e-73

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 226.33  E-value: 1.98e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  34 EPKALVFLNHGYAmECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPSFSDMVDDSSDFFTSVceKQENKNKLR 113
Cdd:pfam12146   2 EPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKI--REEHPGLPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 114 VLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLsDDMKPPQIVVSILSHLTRIIPTWRiVPGQDIIELAFRDPKIREE 193
Cdd:pfam12146  79 FLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-KPYLAPPILKLLAKLLGKLFPRLR-VPNNLLPDSLSRDPEVVAA 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2078402340 194 VRKNPLCyKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLYEKASSTDKTFKLYPGMWHAL 271
Cdd:pfam12146 157 YAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHEL 233
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 1-296 3.58e-39

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 142.34  E-value: 3.58e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   1 MAIEDANVKYEEEFITNSKGVKLFTCRWLPVDCEPKALVFLNHGYAmECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDG 80
Cdd:PLN02652  101 MVEDGEGTRWATSLFYGARRNALFCRSWAPAAGEMRGILIIIHGLN-EHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  81 VLGYIPSFSDMVDDSSDFFTSVceKQENKNKLRVLLGESMGGAMVLR--LHMKKPEFWDGGVLVAPMCKLsddmKPPQ-I 157
Cdd:PLN02652  180 LHGYVPSLDYVVEDTEAFLEKI--RSENPGVPCFLFGHSTGGAVVLKaaSYPSIEDKLEGIVLTSPALRV----KPAHpI 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 158 VVSILSHLTRIIPTWRIVPGQDIIELAFRDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGG 237
Cdd:PLN02652  254 VGAVAPIFSLVAPRFQFKGANKRGIPVSRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGT 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2078402340 238 DDKVTDPTASKLLYEKASSTDKTFKLYPGMWHALTygeFTENTDIVFADIITWINERIA 296
Cdd:PLN02652  334 ADRVTDPLASQDLYNEAASRHKDIKLYDGFLHDLL---FEPEREEVGRDIIDWMEKRLD 389
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
9-293 1.68e-34

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 125.11  E-value: 1.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   9 KYEEEFITNSKGVKLFTCRWLPVDcEPKALVFLNHGYAmECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPSF 88
Cdd:COG2267     2 TRRLVTLPTRDGLRLRGRRWRPAG-SPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  89 SDMVDDSSDFFTSVCEKQENKnklRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPmcklsddmkppqivvsilshltri 168
Cdd:COG2267    80 DDYVDDLRAALDALRARPGLP---VVLLGHSMGGLIALLYAARYPDRVAGLVLLAP------------------------ 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 169 iptwrivpgqdiielafrdpkireEVRKNPLCYkgrVRLQTANELFgvttnLETRLQEVKLPFFLAHGGDDKVTDPTASK 248
Cdd:COG2267   133 ------------------------AYRADPLLG---PSARWLRALR-----LAEALARIDVPVLVLHGGADRVVPPEAAR 180

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2078402340 249 LLYEKAsSTDKTFKLYPGMWHALTygeFTENTDIVFADIITWINE 293
Cdd:COG2267   181 RLAARL-SPDVELVLLPGARHELL---NEPAREEVLAAILAWLER 221
PHA02857 PHA02857
monoglyceride lipase; Provisional
 18-295 7.65e-20

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 87.25  E-value: 7.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  18 SKGVKLFTCRWLPVDCEPKALVFLNHGyAMECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIPSFSDMVDDSSD 97
Cdd:PHA02857    7 NLDNDYIYCKYWKPITYPKALVFISHG-AGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVVQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  98 FFTSVceKQENKNKLRVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCKLSddmKPPQIVVsILSHLTRIIPTWRIVpG 177
Cdd:PHA02857   86 HVVTI--KSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLVNAE---AVPRLNL-LAAKLMGIFYPNKIV-G 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 178 QDIIELAFRDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLYEKASSt 257
Cdd:PHA02857  159 KLCPESVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC- 237

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2078402340 258 DKTFKLYPGMWHALtYGEFTENTDIVFADIITWINERI 295
Cdd:PHA02857  238 NREIKIYEGAKHHL-HKETDEVKKSVMKEIETWIFNRV 274
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
15-295 1.31e-19

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 85.84  E-value: 1.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  15 ITNSKGVKLFTCRWLPVDCEPKALVFLNHGYAMECSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYipsfsDMVDD 94
Cdd:COG1506     2 FKSADGTTLPGWLYLPADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGG-----DEVDD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  95 SSDFFTSVCEKQE-NKNKLrVLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMCklsdDMkppqivVSILSHLTRIIPTWR 173
Cdd:COG1506    77 VLAAIDYLAARPYvDPDRI-GIYGHSYGGYMALLAAARHPDRFKAAVALAGVS----DL------RSYYGTTREYTERLM 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 174 IVPGQDIIELAFRDPkireevrknplcykgrvrlqtanelfgvttnlETRLQEVKLPFFLAHGGDDKVTDPTASKLLYEK 253
Cdd:COG1506   146 GGPWEDPEAYAARSP--------------------------------LAYADKLKTPLLLIHGEADDRVPPEQAERLYEA 193

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2078402340 254 ASSTDKTFKL--YPGMWHALTYGEftenTDIVFADIITWINERI 295
Cdd:COG1506   194 LKKAGKPVELlvYPGEGHGFSGAG----APDYLERILDFLDRHL 233
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 5-293 2.95e-16

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 76.88  E-value: 2.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340   5 DANVKYEEEFITNSKGVKLFTCRWLPVDCEPK--ALVFLnHGYAMECSFSMKGpAMRLVKARFGVYGIDCQGHGKSDGVl 82
Cdd:COG1073     5 SDKVNKEDVTFKSRDGIKLAGDLYLPAGASKKypAVVVA-HGNGGVKEQRALY-AQRLAELGFNVLAFDYRGYGESEGE- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  83 gyiPSFSDMVD--DSSDFFTSVCEKQENKNKLRVLLGESMGGAMVLRLHMKKPEFwDGGVLVAPMCKLSDdmkppqivvs 160
Cdd:COG1073    82 ---PREEGSPErrDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRV-KAVILDSPFTSLED---------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 161 ILSHLTRIIPTwRIVPGqdiielafrdpkireevrknpLCYKGRVRL-QTANELFgvttNLETRLQEVKLPFFLAHGGDD 239
Cdd:COG1073   148 LAAQRAKEARG-AYLPG---------------------VPYLPNVRLaSLLNDEF----DPLAKIEKISRPLLFIHGEKD 201

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2078402340 240 KVTDPTASKLLYEKASStDKTFKLYPGMWHALTYgefTENTDIVFADIITWINE 293
Cdd:COG1073   202 EAVPFYMSEDLYEAAAE-PKELLIVPGAGHVDLY---DRPEEEYFDKLAEFFKK 251
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 59-291 6.36e-13

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 68.27  E-value: 6.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  59 RLVKARFGVYGIDCQGHGKSDG---VLGYIPSFSDMVDDSSDFF-----TSVCEK----------QENKNKLRV---LLG 117
Cdd:TIGR01607  69 NFNKNGYSVYGLDLQGHGESDGlqnLRGHINCFDDLVYDVIQYMnrindSIILENetksddesydIVNTKENRLpmyIIG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 118 ESMGGAMVLR---LHMKKPEFWD-----GGVLVAPMCKLS-----DDMKPPQIVVSILSHLTRIIPTWRIVPGqdiieLA 184
Cdd:TIGR01607 149 LSMGGNIALRlleLLGKSNENNDklnikGCISLSGMISIKsvgsdDSFKFKYFYLPVMNFMSRVFPTFRISKK-----IR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 185 F-RDPKIREEVRKNPLCYKGRVRLQTANELFGVTTNLETRLQEV--KLPFFLAHGGDDKVTDPTASKLLYEKASSTDKTF 261
Cdd:TIGR01607 224 YeKSPYVNDIIKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKEL 303

                         250       260       270
                  ....*....|....*....|....*....|
gi 2078402340 262 KLYPGMWHALTYGEFTENtdiVFADIITWI 291
Cdd:TIGR01607 304 HTLEDMDHVITIEPGNEE---VLKKIIEWI 330
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 36-294 6.86e-10

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 58.09  E-value: 6.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  36 KALVFLnHGYAmeCSFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLGYIpSFSDMVDDSSDFFTSVcekqenknKLR-- 113
Cdd:COG0596    24 PPVVLL-HGLP--GSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGY-TLDDLADDLAALLDAL--------GLErv 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 114 VLLGESMGGAMVLRLHMKKPEFWDGGVLVAPMcklsddmkppqivvsilshltriiptwrivpgQDIIELAFRDPKIREE 193
Cdd:COG0596    92 VLVGHSMGGMVALELAARHPERVAGLVLVDEV--------------------------------LAALAEPLRRPGLAPE 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 194 VrknplcYKGRVRLQTAnelfgvtTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLYEKASstDKTFKLYPGMWHALty 273
Cdd:COG0596   140 A------LAALLRALAR-------TDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLP--NAELVVLPGAGHFP-- 202

                         250       260
                  ....*....|....*....|.
gi 2078402340 274 geFTENTDIVFADIITWINER 294
Cdd:COG0596   203 --PLEQPEAFAAALRDFLARL 221
PRK10749 PRK10749
lysophospholipase L2; Provisional
 65-146 2.59e-06

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 48.46  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  65 FGVYGIDCQGHGKS-----DGVLGYIPSFSDMVDDSSDFFTSvcEKQENKNKLRVLLGESMGGAMVLRLHMKKPEFWDGG 139
Cdd:PRK10749   82 YDVLIIDHRGQGRSgrlldDPHRGHVERFNDYVDDLAAFWQQ--EIQPGPYRKRYALAHSMGGAILTLFLQRHPGVFDAI 159


                  ....*..
gi 2078402340 140 VLVAPMC 146
Cdd:PRK10749  160 ALCAPMF 166
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 38-271 1.92e-05

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 44.77  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  38 LVFLnHGYamecsFSMKGPAMRLVKARFGVYGIDCQGHGKSDGVLgyiPSFSDMVDdssdfFTSVCEKQENKNKlRVLLG 117
Cdd:pfam12697   1 VVLV-HGA-----GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPP---LDLADLAD-----LAALLDELGAARP-VVLVG 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 118 ESMGGAMVLRLHMKKPefwDGGVLVAPMCKLSDDMKPpqiVVSILSHLTRIIPTWRIVPGQDIIELAFRDPKIREEVrkn 197
Cdd:pfam12697  66 HSLGGAVALAAAAAAL---VVGVLVAPLAAPPGLLAA---LLALLARLGAALAAPAWLAAESLARGFLDDLPADAEW--- 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2078402340 198 plcykgRVRLQTANELFGVTTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLyekASSTDKTFKLYPGMWHAL 271
Cdd:pfam12697 137 ------AAALARLAALLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLL---AALAGARLVVLPGAGHLP 201
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 60-266 4.98e-05

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 44.03  E-value: 4.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340  60 LVKARFGVYGIDCQGHGKSDGvLGYIPSFSDmvDDSSDFFTSVCEKqeNKNKLRVLLGESMGGAMVLRLHMKKPEFWDGG 139
Cdd:pfam00561  23 LARDGFRVIALDLRGFGKSSR-PKAQDDYRT--DDLAEDLEYILEA--LGLEKVNLVGHSMGGLIALAYAAKYPDRVKAL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 140 VLVAPmckLSDDMKPPQIVVSILshltRIIPTWRivpgQDIIELAFRDPKIR-------------EEVRKNPL----CYK 202
Cdd:pfam00561  98 VLLGA---LDPPHELDEADRFIL----ALFPGFF----DGFVADFAPNPLGRlvakllallllrlRLLKALPLlnkrFPS 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2078402340 203 GRVRLQTANELFGV-------TTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLyeKASSTDKTFKLYPG 266
Cdd:pfam00561 167 GDYALAKSLVTGALlfietwsTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKL--AQLFPNARLVVIPD 235
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
230-296 2.93e-04

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 41.40  E-value: 2.93e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2078402340 230 PFFLAHGGDDKVTDPtaSKLLYEK--ASSTDKTFKLYPGMWHALTYGEFTENTDIVFADIITWINERIA 296
Cdd:COG0657   141 PTLIVTGEADPLVDE--SEALAAAlrAAGVPVELHVYPGGGHGFGLLAGLPEARAALAEIAAFLRRALA 207
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 227-276 5.70e-03

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 37.36  E-value: 5.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2078402340 227 VKLPFFLAHGGDDKVTDPTASKLLYE--KASSTDKTFKLYPGMWHALTYGEF 276
Cdd:pfam02230 155 KKTPIFLIHGEEDPVVPLALGKLAKEylKTSLNKVELKIYEGLAHSICGREM 206
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
215-272 8.61e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 36.87  E-value: 8.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2078402340 215 GVTTNLETRLQEVKLPFFLAHGGDDKVTDPTASKLLYE--KASSTDKTFKLYPGMWHALT 272
Cdd:COG0412   143 LPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAalAAAGVDVELHVYPGAGHGFT 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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