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Conserved domains on  [gi|1333548784|ref|XP_023505016|]
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cell migration-inducing and hyaluronan-binding protein isoform X1 [Equus caballus]

Protein Classification

FAM3C domain-containing protein; glycosyltransferase family 13 protein( domain architecture ID 10562737)

FAM3C (FAM3 Metabolism Regulating Signaling Molecule C) domain-containing protein; glycosyltransferase family 13 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PANDER_like super family cl19122
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 1294-1450 9.55e-94

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


The actual alignment was detected with superfamily member cd13941:

Pssm-ID: 473142  Cd Length: 157  Bit Score: 298.64  E-value: 9.55e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1294 KTKDHFLEVKMESSEQPFFHLLSNFAYIEVDGKRYPSTEDGIQVVVIDGSQGRVVSHASFRNAILQGIPWQVFNYVAAIP 1373
Cdd:cd13941      1 KTKDHFLEVKIESYKTRYFHLKDDFAYIEVDGKKFFLSEDGIQVVVIDGHSGKVVDTTSFRNSILQGIPAQLENYVTNIK 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333548784 1374 DNSIVLMASKGRYISRGPWTRVLEKLGADEGLRLREKMAFIGFKGSFRPTWVTLDTEDHKAKIFQVVPIPVVRKKKL 1450
Cdd:cd13941     81 DNSIVLITSKGRLVSRGPWTKVLEKLGADQGFKLKEKMAFVGFKGSFRPVWVKLVTDDEAAKIFQALPIPVVKKMKL 157
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 230-392 2.36e-91

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


:

Pssm-ID: 260112  Cd Length: 168  Bit Score: 292.69  E-value: 2.36e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  230 KYIGVGRGGTLELHGQKKLSWTFLNKT-LHPGGMEEGGYFFERSWGHRGVIVHVIDPKSGAVIHSDRFDTYSSKKESERL 308
Cdd:cd13938      1 KFIGVGAGGTLEIHGKKKLSWTLLTKTvLHPGLPKGGGYSFERSWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  309 VQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFRHPWSFITVKGSPSSSVEDHIEYQGH----RGSA 384
Cdd:cd13938     81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQPWAFVGVKGGPSSAVEDRREYEGHsttgTALA 160


                   ....*...
gi 1333548784  385 AARVFKLF 392
Cdd:cd13938    161 AREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 135-254 2.53e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 130.80  E-value: 2.53e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  135 WSPGHN--QDHRVHIGRGRTLLL-TSSATVHSIHITdgGKLVIKDhDETIVLRTRHILIdNGGELHAGSALCPFQGNFSI 211
Cdd:pfam10162    2 WGGGVVpqPGDNVVIPAGQTVLLdVSSPTLKSLVIQ--GTLIFDD-DKNITLRARYILV-QGGRLIIGSEDCPFQGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1333548784  212 VLYGRADEGLPPDPYYSLKYIGVGRGGTLELHGQKKL-SWTFLN 254
Cdd:pfam10162   78 TLHGRPELDDDDGPNYGSKVIGVRNGGTLELHGQPPTvTWTKLA 121
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 414-492 7.67e-14

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 68.13  E-value: 7.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  414 WTEWFEHDKVSQTKGG--EKISDLRAAhpGKICNRPIDIQA----TTADGVNLTTEVVYKrGQDYRFACYDR---GRPCQ 484
Cdd:pfam13330    1 WTPWFDVDNPSGSGGGdfETLENLRAY--GKFCENPTDIECraepPTGVPASETGQVVTC-DVTTGLVCRNAdqqPDGCL 77


                   ....*...
gi 1333548784  485 GYRVRFLC 492
Cdd:pfam13330   78 DYEVRFLC 85
 
Name Accession Description Interval E-value
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 1294-1450 9.55e-94

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 298.64  E-value: 9.55e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1294 KTKDHFLEVKMESSEQPFFHLLSNFAYIEVDGKRYPSTEDGIQVVVIDGSQGRVVSHASFRNAILQGIPWQVFNYVAAIP 1373
Cdd:cd13941      1 KTKDHFLEVKIESYKTRYFHLKDDFAYIEVDGKKFFLSEDGIQVVVIDGHSGKVVDTTSFRNSILQGIPAQLENYVTNIK 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333548784 1374 DNSIVLMASKGRYISRGPWTRVLEKLGADEGLRLREKMAFIGFKGSFRPTWVTLDTEDHKAKIFQVVPIPVVRKKKL 1450
Cdd:cd13941     81 DNSIVLITSKGRLVSRGPWTKVLEKLGADQGFKLKEKMAFVGFKGSFRPVWVKLVTDDEAAKIFQALPIPVVKKMKL 157
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 230-392 2.36e-91

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 292.69  E-value: 2.36e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  230 KYIGVGRGGTLELHGQKKLSWTFLNKT-LHPGGMEEGGYFFERSWGHRGVIVHVIDPKSGAVIHSDRFDTYSSKKESERL 308
Cdd:cd13938      1 KFIGVGAGGTLEIHGKKKLSWTLLTKTvLHPGLPKGGGYSFERSWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  309 VQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFRHPWSFITVKGSPSSSVEDHIEYQGH----RGSA 384
Cdd:cd13938     81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQPWAFVGVKGGPSSAVEDRREYEGHsttgTALA 160


                   ....*...
gi 1333548784  385 AARVFKLF 392
Cdd:cd13938    161 AREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 135-254 2.53e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 130.80  E-value: 2.53e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  135 WSPGHN--QDHRVHIGRGRTLLL-TSSATVHSIHITdgGKLVIKDhDETIVLRTRHILIdNGGELHAGSALCPFQGNFSI 211
Cdd:pfam10162    2 WGGGVVpqPGDNVVIPAGQTVLLdVSSPTLKSLVIQ--GTLIFDD-DKNITLRARYILV-QGGRLIIGSEDCPFQGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1333548784  212 VLYGRADEGLPPDPYYSLKYIGVGRGGTLELHGQKKL-SWTFLN 254
Cdd:pfam10162   78 TLHGRPELDDDDGPNYGSKVIGVRNGGTLELHGQPPTvTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 276-365 2.60e-30

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 115.44  E-value: 2.60e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  276 RGVIVHVIDPKSGAVIHSDRFDTYSSKkESERLVQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFR 355
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDTYSYS-DSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFR 79

                           90
                   ....*....|
gi 1333548784  356 HPWSFITVKG 365
Cdd:pfam15711   80 DSWAFIGFKG 89
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1333-1418 5.32e-18

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 80.00  E-value: 5.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1333 DGIQVVVIDGSQGRVVSHASFRNaILQGIPWQVFNYVAAIPDNSIVLMASKGRYISR--GPWTRVLEKLGADEGLRL--R 1408
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDT-YSYSDSSRLANFLKSIPDGSIVLIATKDEASSKlsDEARKALESLGSSKIDNLgfR 79

                           90
                   ....*....|
gi 1333548784 1409 EKMAFIGFKG 1418
Cdd:pfam15711   80 DSWAFIGFKG 89
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 414-492 7.67e-14

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 68.13  E-value: 7.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  414 WTEWFEHDKVSQTKGG--EKISDLRAAhpGKICNRPIDIQA----TTADGVNLTTEVVYKrGQDYRFACYDR---GRPCQ 484
Cdd:pfam13330    1 WTPWFDVDNPSGSGGGdfETLENLRAY--GKFCENPTDIECraepPTGVPASETGQVVTC-DVTTGLVCRNAdqqPDGCL 77


                   ....*...
gi 1333548784  485 GYRVRFLC 492
Cdd:pfam13330   78 DYEVRFLC 85
 
Name Accession Description Interval E-value
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 1294-1450 9.55e-94

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 298.64  E-value: 9.55e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1294 KTKDHFLEVKMESSEQPFFHLLSNFAYIEVDGKRYPSTEDGIQVVVIDGSQGRVVSHASFRNAILQGIPWQVFNYVAAIP 1373
Cdd:cd13941      1 KTKDHFLEVKIESYKTRYFHLKDDFAYIEVDGKKFFLSEDGIQVVVIDGHSGKVVDTTSFRNSILQGIPAQLENYVTNIK 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333548784 1374 DNSIVLMASKGRYISRGPWTRVLEKLGADEGLRLREKMAFIGFKGSFRPTWVTLDTEDHKAKIFQVVPIPVVRKKKL 1450
Cdd:cd13941     81 DNSIVLITSKGRLVSRGPWTKVLEKLGADQGFKLKEKMAFVGFKGSFRPVWVKLVTDDEAAKIFQALPIPVVKKMKL 157
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 230-392 2.36e-91

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 292.69  E-value: 2.36e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  230 KYIGVGRGGTLELHGQKKLSWTFLNKT-LHPGGMEEGGYFFERSWGHRGVIVHVIDPKSGAVIHSDRFDTYSSKKESERL 308
Cdd:cd13938      1 KFIGVGAGGTLEIHGKKKLSWTLLTKTvLHPGLPKGGGYSFERSWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  309 VQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFRHPWSFITVKGSPSSSVEDHIEYQGH----RGSA 384
Cdd:cd13938     81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQPWAFVGVKGGPSSAVEDRREYEGHsttgTALA 160


                   ....*...
gi 1333548784  385 AARVFKLF 392
Cdd:cd13938    161 AREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 135-254 2.53e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 130.80  E-value: 2.53e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  135 WSPGHN--QDHRVHIGRGRTLLL-TSSATVHSIHITdgGKLVIKDhDETIVLRTRHILIdNGGELHAGSALCPFQGNFSI 211
Cdd:pfam10162    2 WGGGVVpqPGDNVVIPAGQTVLLdVSSPTLKSLVIQ--GTLIFDD-DKNITLRARYILV-QGGRLIIGSEDCPFQGKATI 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1333548784  212 VLYGRADEGLPPDPYYSLKYIGVGRGGTLELHGQKKL-SWTFLN 254
Cdd:pfam10162   78 TLHGRPELDDDDGPNYGSKVIGVRNGGTLELHGQPPTvTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 276-365 2.60e-30

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 115.44  E-value: 2.60e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  276 RGVIVHVIDPKSGAVIHSDRFDTYSSKkESERLVQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFR 355
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDTYSYS-DSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFR 79

                           90
                   ....*....|
gi 1333548784  356 HPWSFITVKG 365
Cdd:pfam15711   80 DSWAFIGFKG 89
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 1300-1450 7.71e-28

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 110.50  E-value: 7.71e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1300 LEVKMESSEQpffhllSNFAYIEVDGKRYPST---EDGIQVVVIDGSQGRVVSHASFRNAIlQGIPWQVFNYVAAIPDNS 1376
Cdd:cd13936      1 LEVKIASGGG------GNYAKICVNGGVLFDGdksGRGINVVVINGDTGKVIATKTFDTYG-AGASNDMIDFLNSVPPGS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1377 IVLMASKGRYISR--GPWTRVLEKLGADEGLRL--REKMAFIGFKGSFRPTWvtldtEDHKAKIFQV---VPIPVVRKKK 1449
Cdd:cd13936     74 IVLIATKDDASKSlkDEARRALESLGSSLIQNLgfRDSWAFVGQKGIKRPST-----EQHEISPKNSswgGPALIQTCFP 148


                   .
gi 1333548784 1450 L 1450
Cdd:cd13936    149 L 149
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 264-375 3.21e-24

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 100.10  E-value: 3.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  264 EGGYFFERSWGHRGVIVHVIDPKSGAVIHSDRFDTYSSKkESERLVQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTR 343
Cdd:cd13936     19 NGGVLFDGDKSGRGINVVVINGDTGKVIATKTFDTYGAG-ASNDMIDFLNSVPPGSIVLIATKDDASKSLKDEARRALES 97

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1333548784  344 LGSKHFLHLGFRHPWSFITVKGSPSSSVEDHI 375
Cdd:cd13936     98 LGSSLIQNLGFRDSWAFVGQKGIKRPSTEQHE 129
PANDER_GnT-1_2_like cd13937
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ...
 276-370 4.38e-19

PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined.


Pssm-ID: 260111  Cd Length: 148  Bit Score: 85.43  E-value: 4.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  276 RGVIVHVIDPKSGAVIHSDRFDTYSSKkESERLVQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFR 355
Cdd:cd13937     31 RGIHVVVLNQATGSVMAQRVFDTYSPG-EDEAMILFLNMVSDGRILIFTIKDEGSFHLKDEARSLLKKLGSQKVSKLGWR 109

                           90
                   ....*....|....*
gi 1333548784  356 HPWSFITVKGSPSSS 370
Cdd:cd13937    110 DMWAMVTRKGGPVYG 124
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1333-1418 5.32e-18

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 80.00  E-value: 5.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784 1333 DGIQVVVIDGSQGRVVSHASFRNaILQGIPWQVFNYVAAIPDNSIVLMASKGRYISR--GPWTRVLEKLGADEGLRL--R 1408
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDT-YSYSDSSRLANFLKSIPDGSIVLIATKDEASSKlsDEARKALESLGSSKIDNLgfR 79

                           90
                   ....*....|
gi 1333548784 1409 EKMAFIGFKG 1418
Cdd:pfam15711   80 DSWAFIGFKG 89
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 414-492 7.67e-14

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 68.13  E-value: 7.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  414 WTEWFEHDKVSQTKGG--EKISDLRAAhpGKICNRPIDIQA----TTADGVNLTTEVVYKrGQDYRFACYDR---GRPCQ 484
Cdd:pfam13330    1 WTPWFDVDNPSGSGGGdfETLENLRAY--GKFCENPTDIECraepPTGVPASETGQVVTC-DVTTGLVCRNAdqqPDGCL 77


                   ....*...
gi 1333548784  485 GYRVRFLC 492
Cdd:pfam13330   78 DYEVRFLC 85
PANDER_FAM3B cd13939
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ...
 276-376 3.54e-13

Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver.


Pssm-ID: 260113  Cd Length: 175  Bit Score: 69.18  E-value: 3.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  276 RGVIVHVIDPKSGAVIHSDRFDTYSSKKeSERLVQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFR 355
Cdd:cd13939     49 RGINIAVVSYETGKVVATKYFDMYEGDF-SGPMIEFINKIPKKSLVFVVTHDDGSTKLKDPAKKAIEDLGSKEIRNLKFR 127

                           90       100
                   ....*....|....*....|.
gi 1333548784  356 HPWSFITVKGspsSSVEDHIE 376
Cdd:cd13939    128 SAWVFIAAKG---FQLPDNIE 145
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 276-375 5.32e-13

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 68.45  E-value: 5.32e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333548784  276 RGVIVHVIDPKSGAVIHSDRFDTYSskKESERLVQSLNAVPDGRILSIAVNDEGSRNLDDVARKAMTRLGSKHFLHLGFR 355
Cdd:cd13940     50 RGLNIALVNGETGEVLKTGFFDMYS--GDVKPLLEFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFR 127

                           90       100
                   ....*....|....*....|.
gi 1333548784  356 HPWSFITVKGSPS-SSVEDHI 375
Cdd:cd13940    128 DNWVFVGGKGIKTkSPFEKHI 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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