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Conserved domains on  [gi|1333690095|ref|XP_023500003|]
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phospholipid phosphatase 2 isoform X1 [Equus caballus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 94-240 6.43e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 218.27  E-value: 6.43e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQVE---KVCRGSHANVTEARLSFYSGHSS 170
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIadcTCCTGDPDLIREARLSFPSGHAS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 171 FGMYCMMFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTV 240
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 94-240 6.43e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 218.27  E-value: 6.43e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQVE---KVCRGSHANVTEARLSFYSGHSS 170
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIadcTCCTGDPDLIREARLSFPSGHAS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 171 FGMYCMMFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTV 240
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
103-236 4.28e-25

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 96.65  E-value: 4.28e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  103 LFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPdwsrvncsvyvqvekVCRGSHANVTEARLSFYSGHSSFGMYCMMFLALY 182
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA---------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1333690095  183 vqarlcwKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVA 236
Cdd:smart00014  66 -------LPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIA 112
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 102-243 1.70e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 82.08  E-value: 1.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 102 FLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSrvncsvyvqvekvcrgSHANVTEARLSFYSGHSSFGMYCMMFLAL 181
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333690095 182 YVqARLCWKWARLLRptvqFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVRYV 243
Cdd:pfam01569  66 LL-RRLRKIVRVLLA----LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 96-257 7.62e-16

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 76.12  E-value: 7.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  96 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQVekVCRGSHANVTEARLSFYSGHSSFGMYC 175
Cdd:PLN02250   98 HAILG-LLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVTTDV--LCTGAKSVIKEGHKSFPSGHTSWSFAG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 176 MMFLALYV--QARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAglTVRYVSDFfkvrPPL 253
Cdd:PLN02250  175 LGFLSLYLsgKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA--SFCYLQFF----PPP 248


                  ....
gi 1333690095 254 HGPE 257
Cdd:PLN02250  249 YDID 252
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 98-243 8.56e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 48.50  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  98 VLGTFLFGAAVSQSLTDLAKYMIGRLRPNFlavcdpdwsrvncsvyvqvekVCRGSHANVTEARLSFYSGHSSFGMYCMM 177
Cdd:COG0671    74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFV---------------------VPDLELLLGTAGGYSFPSGHAAAAFALAL 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333690095 178 FLALYVQARLCWkwarllrptvqFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVRYV 243
Cdd:COG0671   133 VLALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 94-240 6.43e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 218.27  E-value: 6.43e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQVE---KVCRGSHANVTEARLSFYSGHSS 170
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIadcTCCTGDPDLIREARLSFPSGHAS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 171 FGMYCMMFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTV 240
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 42-243 3.68e-30

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 112.31  E-value: 3.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  42 SIRYPYHPDTITHGLMAGVTITATVVLVSAGEAYLVHTDRLysrsDFNNYVAAiykvlgtFLFGAAVSQSLTDLAKYMIG 121
Cdd:cd03390     2 SISYPFAESETVPTWLLVIISVGIPLLVIILISLFFRRSLW----DLHTSLLG-------LLLSVSLNGVITNVLKNYAG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 122 RLRPNFLAVCDPDwSRVNCSVYVQVEKVCRGSHANVTEARLSFYSGHSSFGMYCMMFLALYVQARL-CWKWA-RLLRPTV 199
Cdd:cd03390    71 RPRPDFLARCFPD-GGTPSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLhIFDPRgSSWRLLL 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1333690095 200 QFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVRYV 243
Cdd:cd03390   150 ALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
acidPPc smart00014
Acid phosphatase homologues;
103-236 4.28e-25

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 96.65  E-value: 4.28e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  103 LFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPdwsrvncsvyvqvekVCRGSHANVTEARLSFYSGHSSFGMYCMMFLALY 182
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA---------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1333690095  183 vqarlcwKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVA 236
Cdd:smart00014  66 -------LPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIA 112
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 96-240 1.59e-21

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 87.52  E-value: 1.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  96 YKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDwsrvncsvyvqvekvcrGSHANVTEARLSFYSGHSSFGMYC 175
Cdd:cd01610     2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFAL 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333690095 176 MMFLALYVqarlcwkWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTV 240
Cdd:cd01610    65 ALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 102-243 1.70e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 82.08  E-value: 1.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 102 FLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSrvncsvyvqvekvcrgSHANVTEARLSFYSGHSSFGMYCMMFLAL 181
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333690095 182 YVqARLCWKWARLLRptvqFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVRYV 243
Cdd:pfam01569  66 LL-RRLRKIVRVLLA----LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 96-257 7.62e-16

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 76.12  E-value: 7.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  96 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQVekVCRGSHANVTEARLSFYSGHSSFGMYC 175
Cdd:PLN02250   98 HAILG-LLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVTTDV--LCTGAKSVIKEGHKSFPSGHTSWSFAG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 176 MMFLALYV--QARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAglTVRYVSDFfkvrPPL 253
Cdd:PLN02250  175 LGFLSLYLsgKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA--SFCYLQFF----PPP 248


                  ....
gi 1333690095 254 HGPE 257
Cdd:PLN02250  249 YDID 252
PLN02715 PLN02715
lipid phosphate phosphatase
 96-241 2.33e-15

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 75.09  E-value: 2.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  96 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYvqvEKVCRGSHANVTEARLSFYSGHSSFGMYC 175
Cdd:PLN02715  123 HSILG-LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALG---GVICHGKAAEVKEGHKSFPSGHTSWSFAG 198

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333690095 176 MMFLALYVQARLCW--KWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVR 241
Cdd:PLN02715  199 LTFLSLYLSGKIKAfnGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYR 266
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 96-254 9.57e-14

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 70.44  E-value: 9.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  96 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYvqvEKVCRGSHANVTEARLSFYSGHSSFGMYC 175
Cdd:PLN02731  117 HAVLG-LLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLG---DVICHGDKSVIREGHKSFPSGHTSWSFSG 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 176 MMFLALYVQARLCW--KWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALvaGLTVRYVSDFfkvRPPL 253
Cdd:PLN02731  193 LGFLSLYLSGKIQAfdGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLA--ISTICYLQFF---PPPY 267


                  .
gi 1333690095 254 H 254
Cdd:PLN02731  268 H 268
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 96-243 4.07e-09

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 53.10  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  96 YKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNflavCDPDWSRvncsvyvqvekvcrgshanvtearlSFYSGHSSFGMYC 175
Cdd:cd03394     2 REGLLILAEAAALTAAVTEGLKFAVGRARPD----GSNNGYR-------------------------SFPSGHTASAFAA 52

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 176 mmflALYVQARLCWKWArllrptvqfFLVAFAL--YVGYTRVSDHKHHWSDVLVgllqGALVAGLTVRYV 243
Cdd:cd03394    53 ----ATFLQYRYGWRWY---------GIPAYALasLVGASRVVANRHWLSDVLA----GAAIGILVGYLV 105
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 98-243 8.56e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 48.50  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  98 VLGTFLFGAAVSQSLTDLAKYMIGRLRPNFlavcdpdwsrvncsvyvqvekVCRGSHANVTEARLSFYSGHSSFGMYCMM 177
Cdd:COG0671    74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFV---------------------VPDLELLLGTAGGYSFPSGHAAAAFALAL 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333690095 178 FLALYVQARLCWkwarllrptvqFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVRYV 243
Cdd:COG0671   133 VLALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 88-239 1.17e-06

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 47.99  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  88 FNNYVAAIYkVLGTFLFGAAVSQSLtdlaKYMIGRLRP-NFLAVCDPDWsrvncsvyvqvekvcrgshanvtearlSFYS 166
Cdd:cd03392    58 KRRRRAALF-LLLALLGGGALNTLL----KLLVQRPRPpLHLLVPEGGY---------------------------SFPS 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333690095 167 GHSSFGMYCMMFLALYVQARLcwkWARLLRPTVQFFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLT 239
Cdd:cd03392   106 GHAMGATVLYGFLAYLLARRL---PRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALL 175
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 166-238 1.53e-04

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 41.49  E-value: 1.53e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333690095 166 SGHSSFgmycMMFLALYVQARLCWKWARLLRPTVQFFLVAF----ALYVGYTRVSDHKHHWSDVLVGLLQGALVAGL 238
Cdd:cd03382    85 SSHSQF----MGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGllllALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 47-243 1.40e-03

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 38.84  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095  47 YHPDTITHGLMAGVTI--TATVVLVSAGEAYLVHTDRlYSRSDFNNYVAAIYKV--LGTFLFGA-AVSQSLTDLAKYMIG 121
Cdd:cd03389    15 ALDGRILAGFFRTITDfgKSGWYLIPSLLLFLLFRFG-DLRGLSAPSRARFPKAawAGLFLFATvALSGILVNLLKFIIG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 122 RLRPNFLavcdpdwsrVNCSVYvqvekvcrGSHANVTEAR-LSFYSGHSsfGMYCMMFLALYvqarlcwkwarLLRPTVQ 200
Cdd:cd03389    94 RARPKLL---------FDDGLY--------GFDPFHADYAfTSFPSGHS--ATAGAAAAALA-----------LLFPRYR 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1333690095 201 FFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVRYV 243
Cdd:cd03389   144 WAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 113-241 5.89e-03

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 36.86  E-value: 5.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333690095 113 TDLAKYMIGRLRPNF-LAVCDpdwsrvncsvyVQVEKVCRGSHanvtearlSFYSGHSSFGMYCMMFLALYVqarlcwkW 191
Cdd:cd03395    73 SGFLKPLVARLRPCNaLDGVR-----------LVVLGDQGGSY--------SFASSHAANSFALALFIWLFF-------R 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333690095 192 ARLLRPtvqfFLVAFALYVGYTRVSDHKHHWSDVLVGLLQGALVAGLTVR 241
Cdd:cd03395   127 RGLFSP----VLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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