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Conserved domains on  [gi|1333636817|ref|XP_023493741|]
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bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial isoform X1 [Equus caballus]

Protein Classification

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11415140)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH:  3.40.50.720|3.40.430.10
EC:  1.5.1.5|3.5.4.9
Gene Ontology:  GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730
PubMed:  8485162
SCOP:  4000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 2-313 9.59e-133

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


:

Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 378.59  E-value: 9.59e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   2 AKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPR 81
Cdd:COG0190    12 AAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALIDELNADPS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  82 VSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNV 161
Cdd:COG0190    91 VHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAVVVGRSNIV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 162 GMPIAMLLhtdgEHErpggDATVTIAHRYTPkeQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPK 241
Cdd:COG0190   171 GKPLALLL----LRR----NATVTVCHSRTK--DLAEHTRQADILVAAV---------------------------GKPG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 242 LITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:COG0190   214 LITADMVKPGAVVIDVGINRVED-----GKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAER 280
 
Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 2-313 9.59e-133

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 378.59  E-value: 9.59e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   2 AKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPR 81
Cdd:COG0190    12 AAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALIDELNADPS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  82 VSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNV 161
Cdd:COG0190    91 VHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAVVVGRSNIV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 162 GMPIAMLLhtdgEHErpggDATVTIAHRYTPkeQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPK 241
Cdd:COG0190   171 GKPLALLL----LRR----NATVTVCHSRTK--DLAEHTRQADILVAAV---------------------------GKPG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 242 LITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:COG0190   214 LITADMVKPGAVVIDVGINRVED-----GKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAER 280
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-315 1.31e-110

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 322.35  E-value: 1.31e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESwisLGNRR--PHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNM 78
Cdd:PRK14190   11 VAKEKREQLKEEVVK---LKEQGivPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELLALIDRLNA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  79 DPRVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRS 158
Cdd:PRK14190   88 DPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGKHVVVVGRS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 159 KNVGMPIAMLLHTDgeherpggDATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTG 238
Cdd:PRK14190  168 NIVGKPVGQLLLNE--------NATVTYCHSKTK--NLAELTKQADILIVA---------------------------VG 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333636817 239 IPKLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14190  211 KPKLITADMVKEGAVVIDVGVNRLEN-----GKLCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAG 282
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 106-312 3.00e-78

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 235.91  E-value: 3.00e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 106 PEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHtdgeherpGGDATVT 185
Cdd:cd01080     1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLL--------NRNATVT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 186 IAHRYTPKeqLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVIDVGINYVHDP 265
Cdd:cd01080    73 VCHSKTKN--LKEHTKQADIVIVAV---------------------------GKPGLVKGDMVKPGAVVIDVGINRVPDK 123

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1333636817 266 vtGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:cd01080   124 --SGGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLMKNTVEAAK 168
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
114-313 6.22e-73

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 221.96  E-value: 6.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 114 HIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDgeherpggDATVTIAHRYTPk 193
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNA--------NATVTVCHSKTK- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 194 eQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVIDVGINYVhdpvtGKTKLV 273
Cdd:pfam02882  72 -DLAEITREADIVVVAV---------------------------GKPELIKADWIKPGAVVIDVGINRV-----GNGKLV 118

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1333636817 274 GDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:pfam02882 119 GDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKR 158
 
Name Accession Description Interval E-value
FolD COG0190
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...
 2-313 9.59e-133

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];


Pssm-ID: 439960 [Multi-domain]  Cd Length: 285  Bit Score: 378.59  E-value: 9.59e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   2 AKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPR 81
Cdd:COG0190    12 AAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELLALIDELNADPS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  82 VSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNV 161
Cdd:COG0190    91 VHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGKHAVVVGRSNIV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 162 GMPIAMLLhtdgEHErpggDATVTIAHRYTPkeQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPK 241
Cdd:COG0190   171 GKPLALLL----LRR----NATVTVCHSRTK--DLAEHTRQADILVAAV---------------------------GKPG 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 242 LITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:COG0190   214 LITADMVKPGAVVIDVGINRVED-----GKLVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAER 280
PRK14190 PRK14190
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-315 1.31e-110

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184560 [Multi-domain]  Cd Length: 284  Bit Score: 322.35  E-value: 1.31e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESwisLGNRR--PHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNM 78
Cdd:PRK14190   11 VAKEKREQLKEEVVK---LKEQGivPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELLALIDRLNA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  79 DPRVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRS 158
Cdd:PRK14190   88 DPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGKHVVVVGRS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 159 KNVGMPIAMLLHTDgeherpggDATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTG 238
Cdd:PRK14190  168 NIVGKPVGQLLLNE--------NATVTYCHSKTK--NLAELTKQADILIVA---------------------------VG 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333636817 239 IPKLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14190  211 KPKLITADMVKEGAVVIDVGVNRLEN-----GKLCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAG 282
PRK10792 PRK10792
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 2-313 4.21e-99

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 236760 [Multi-domain]  Cd Length: 285  Bit Score: 293.36  E-value: 4.21e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   2 AKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPR 81
Cdd:PRK10792   12 AQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELLALIDELNADPT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  82 VSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNV 161
Cdd:PRK10792   92 IDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGLNAVVVGASNIV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 162 GMPIAMLLHTDGeherpggdATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIPK 241
Cdd:PRK10792  172 GRPMSLELLLAG--------CTVTVCHRFTK--NLRHHVRNADLLVVA---------------------------VGKPG 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 242 LITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK10792  215 FIPGEWIKPGAIVIDVGINRLED-----GKLVGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEE 281
PRK14186 PRK14186
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-313 8.49e-97

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237636 [Multi-domain]  Cd Length: 297  Bit Score: 287.73  E-value: 8.49e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14186   10 LAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEALIAQLNQDE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14186   90 RVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKKAVVVGRSIL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTdgeherpgGDATVTIAHRYTPkeQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIP 240
Cdd:PRK14186  170 VGKPLALMLLA--------ANATVTIAHSRTQ--DLASITREADILVAAA---------------------------GRP 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDPvTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14186  213 NLIGAEMVKPGAVVVDVGIHRLPSS-DGKTRLCGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLSWQK 284
PRK14189 PRK14189
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
1-314 5.23e-91

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 184559 [Multi-domain]  Cd Length: 285  Bit Score: 272.72  E-value: 5.23e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRrPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14189   11 LSKQLRAEAAQRAAALTARGHQ-PGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELLARIDELNRDP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14189   90 KIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGAHAVVIGRSNI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDGeherpggdATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14189  170 VGKPMAMLLLQAG--------ATVTICHSKTR--DLAAHTRQADIVVAA---------------------------VGKR 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQT 314
Cdd:PRK14189  213 NVLTADMVKPGATVIDVGMNRDDA-----GKLCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAERA 281
PRK14191 PRK14191
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-312 4.56e-90

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172679 [Multi-domain]  Cd Length: 285  Bit Score: 270.10  E-value: 4.56e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14191    9 LSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLIKDLNTDQ 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14191   89 NIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVVIIGASNI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDGeherpggdATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14191  169 VGKPLAMLMLNAG--------ASVSVCHILT--KDLSFYTQNADIVCVG---------------------------VGKP 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:PRK14191  212 DLIKASMVKKGAVVVDIGINRLND-----GRLVGDVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAE 278
PRK14188 PRK14188
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 20-314 2.22e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184558 [Multi-domain]  Cd Length: 296  Bit Score: 266.44  E-value: 2.22e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  20 GNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVDERT 99
Cdd:PRK14188   29 HGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLALIARLNADPAIHGILVQLPLPKHLDSEA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 100 VCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDgeherpg 179
Cdd:PRK14188  109 VIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLNAVVIGRSNLVGKPMAQLLLAA------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 180 gDATVTIAHrytpkeqlkIHTQ-LADV-----IIVAAetlgfihktqnlnhleiivtsqwwlkTGIPKLITSDMVKEGAA 253
Cdd:PRK14188  182 -NATVTIAH---------SRTRdLPAVcrradILVAA--------------------------VGRPEMVKGDWIKPGAT 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 254 VIDVGINYVHDP--VTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQT 314
Cdd:PRK14188  226 VIDVGINRIPAPekGEGKTRLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAACRA 288
PRK14176 PRK14176
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-315 3.31e-86

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184553 [Multi-domain]  Cd Length: 287  Bit Score: 260.51  E-value: 3.31e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14176   16 LAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELIDSLNKRK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14176   96 DVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAVIVGHSNV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIA-MLLHTdgeherpggDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGI 239
Cdd:PRK14176  176 VGKPMAaMLLNR---------NATVSVCHVFT--DDLKKYTLDADILVVA---------------------------TGV 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333636817 240 PKLITSDMVKEGAAVIDVGINYVHDpvtgktKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14176  218 KHLIKADMVKEGAVIFDVGITKEED------KVYGDVDFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEKSL 287
PRK14184 PRK14184
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 2-313 1.38e-82

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237635 [Multi-domain]  Cd Length: 286  Bit Score: 251.23  E-value: 1.38e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   2 AKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPR 81
Cdd:PRK14184   10 AATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLIAELNARPD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  82 VSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNV 161
Cdd:PRK14184   90 IDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAVVVGRSNIV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 162 GMPIAMLLHTDGeherPGGDATVTIAHRYTPkeQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPK 241
Cdd:PRK14184  170 GKPLALMLGAPG----KFANATVTVCHSRTP--DLAEECREADFLFVAI---------------------------GRPR 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 242 LITSDMVKEGAAVIDVGINYVHDpvtgktKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14184  217 FVTADMVKPGAVVVDVGINRTDD------GLVGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKE 282
PRK14167 PRK14167
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-311 2.07e-82

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184549 [Multi-domain]  Cd Length: 297  Bit Score: 251.23  E-value: 2.07e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRrPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14167   10 VAAQIRDDLTDAIETLEDAGVT-PGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDTIDELNADE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14167   89 DVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADVVVVGRSDI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDGeherPGGDATVTIAHRYTpkEQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIP 240
Cdd:PRK14167  169 VGKPMANLLIQKA----DGGNATVTVCHSRT--DDLAAKTRRADIVVAAA---------------------------GVP 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAA 311
Cdd:PRK14167  216 ELIDGSMLSEGATVIDVGINRVDADTEKGYELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAA 286
PRK14179 PRK14179
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;
1-315 1.06e-81

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;


Pssm-ID: 237634 [Multi-domain]  Cd Length: 284  Bit Score: 248.90  E-value: 1.06e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14179   10 LAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDLIERYNQDP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14179   90 TWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHAVVIGRSNI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDgeherpggDATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14179  170 VGKPMAQLLLDK--------NATVTLTHSRTR--NLAEVARKADILVVA---------------------------IGRG 212

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14179  213 HFVTKEFVKEGAVVIDVGMNRDEN-----GKLIGDVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAALRSL 282
PRK14185 PRK14185
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-316 1.44e-80

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184556 [Multi-domain]  Cd Length: 293  Bit Score: 246.28  E-value: 1.44e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14185    9 ISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKVRELNQDD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14185   89 DVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCVVLGRSNI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDGEherpGGDATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14185  169 VGKPMAQLMMQKAY----PGDCTVTVCHSRSK--NLKKECLEADIIIAA---------------------------LGQP 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDPVTGKT-KLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTLY 316
Cdd:PRK14185  216 EFVKADMVKEGAVVIDVGTTRVPDATRKSGfKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGKKAIY 292
PRK14174 PRK14174
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 4-308 7.38e-80

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172662 [Multi-domain]  Cd Length: 295  Bit Score: 244.73  E-value: 7.38e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   4 QIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVS 83
Cdd:PRK14174   12 DLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKIEDLNNDPDVH 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  84 GILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQ--HSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNV 161
Cdd:PRK14174   92 GILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGHldKCFVSCTPYGILELLGRYNIETKGKHCVVVGRSNIV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 162 GMPIAMLLHtdgeHERPGGDATVTIAHRYTPkeQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIPK 241
Cdd:PRK14174  172 GKPMANLML----QKLKESNCTVTICHSATK--DIPSYTRQADILIAA---------------------------IGKAR 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333636817 242 LITSDMVKEGAAVIDVGINYVHDPVTGK-TKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTL 308
Cdd:PRK14174  219 FITADMVKPGAVVIDVGINRIEDPSTKSgYRLVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTL 286
PRK14183 PRK14183
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-313 1.11e-79

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184555 [Multi-domain]  Cd Length: 281  Bit Score: 243.58  E-value: 1.11e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14183    9 LSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETIAMMNNNP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14183   89 NIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVCVVGASNI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDGeherpggdATVTIAHRYTpkEQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIP 240
Cdd:PRK14183  169 VGKPMAALLLNAN--------ATVDICHIFT--KDLKAHTKKADIVIVGV---------------------------GKP 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14183  212 NLITEDMVKEGAIVIDIGINRTED-----GRLVGDVDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKAAKN 279
PLN02516 PLN02516
methylenetetrahydrofolate dehydrogenase (NADP+)
 1-313 1.49e-79

methylenetetrahydrofolate dehydrogenase (NADP+)


Pssm-ID: 178131 [Multi-domain]  Cd Length: 299  Bit Score: 244.03  E-value: 1.49e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PLN02516   17 IAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELISKVHELNANP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLD--QHSLMPATASAVWEIIKRAGIETFGKNVVVAGRS 158
Cdd:PLN02516   97 DVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKgrEPLFLPCTPKGCLELLSRSGIPIKGKKAVVVGRS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 159 KNVGMPIAMLLHTdgeherpgGDATVTIAHRYTPKEQLKIHTqlADVIIVAAetlgfihktqnlnhleiivtsqwwlktG 238
Cdd:PLN02516  177 NIVGLPVSLLLLK--------ADATVTVVHSRTPDPESIVRE--ADIVIAAA---------------------------G 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333636817 239 IPKLITSDMVKEGAAVIDVGINYVHDPvTGKT--KLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PLN02516  220 QAMMIKGDWIKPGAAVIDVGTNAVSDP-SKKSgyRLVGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTVDGAKR 295
PRK14168 PRK14168
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 3-312 8.58e-79

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 237633 [Multi-domain]  Cd Length: 297  Bit Score: 242.09  E-value: 8.58e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   3 KQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRV 82
Cdd:PRK14168   13 EEILEEIRGEVAELKEKYGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELLALIDKYNNDDSI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  83 SGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCL--DQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14168   93 HGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIggDEVKFLPCTPAGIQEMLVRSGVETSGAEVVVVGRSNI 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDGeherPGGDATVTIAHryTPKEQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIP 240
Cdd:PRK14168  173 VGKPIANMMTQKG----PGANATVTIVH--TRSKNLARHCQRADILIVAA---------------------------GVP 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYV-HDPVTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:PRK14168  220 NLVKPEWIKPGATVIDVGVNRVgTNESTGKAILSGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKSAK 292
NAD_bind_m-THF_DH_Cyclohyd cd01080
NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...
 106-312 3.00e-78

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.


Pssm-ID: 133448  Cd Length: 168  Bit Score: 235.91  E-value: 3.00e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 106 PEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHtdgeherpGGDATVT 185
Cdd:cd01080     1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLL--------NRNATVT 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 186 IAHRYTPKeqLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVIDVGINYVHDP 265
Cdd:cd01080    73 VCHSKTKN--LKEHTKQADIVIVAV---------------------------GKPGLVKGDMVKPGAVVIDVGINRVPDK 123

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1333636817 266 vtGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:cd01080   124 --SGGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLMKNTVEAAK 168
PRK14173 PRK14173
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 23-311 3.76e-78

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 184551 [Multi-domain]  Cd Length: 287  Bit Score: 240.12  E-value: 3.76e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  23 RPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVDERTVCN 102
Cdd:PRK14173   29 VPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELLELIARLNADPEVDGILVQLPLPPHIDFQRVLE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 103 GIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHtdgeherpGGDA 182
Cdd:PRK14173  109 AIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGKEVVVVGRSNIVGKPLAALLL--------REDA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 183 TVTIAHRYTPkeQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVIDVGINYV 262
Cdd:PRK14173  181 TVTLAHSKTQ--DLPAVTRRADVLVVAV---------------------------GRPHLITPEMVRPGAVVVDVGINRV 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1333636817 263 HDPvTGKTKLVGDVDFEaVKRKAGFITPVPGGVGPVTVAMLLKNTLLAA 311
Cdd:PRK14173  232 GGN-GGRDILTGDVHPE-VAEVAGALTPVPGGVGPMTVAMLMANTVIAA 278
PRK14175 PRK14175
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 3-312 3.69e-77

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184552 [Multi-domain]  Cd Length: 286  Bit Score: 237.51  E-value: 3.69e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   3 KQIQKEIQRGVESWISLGNRR---PHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMD 79
Cdd:PRK14175    9 KQIAKDYRQGLQDQVEALKEKgftPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVLNELNRLNND 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  80 PRVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSK 159
Cdd:PRK14175   89 DSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGKNAVVIGRSH 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 160 NVGMPIAMLLHTdgeherpgGDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGI 239
Cdd:PRK14175  169 IVGQPVSKLLLQ--------KNASVTILHSRS--KDMASYLKDADVIVSA---------------------------VGK 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 240 PKLITSDMVKEGAAVIDVGinyvhDPVTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:PRK14175  212 PGLVTKDVVKEGAVIIDVG-----NTPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEK 279
PRK14193 PRK14193
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 22-315 1.05e-76

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 237637 [Multi-domain]  Cd Length: 284  Bit Score: 236.06  E-value: 1.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  22 RRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVDERTVC 101
Cdd:PRK14193   31 ITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELNAVIDELNADPACTGYIVQLPLPKHLDENAVL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 102 NGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLhtdgehERPGGD 181
Cdd:PRK14193  111 ERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGAHVVVIGRGVTVGRPIGLLL------TRRSEN 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 182 ATVTIAHryTPKEQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVIDVGINY 261
Cdd:PRK14193  185 ATVTLCH--TGTRDLAAHTRRADIIVAAA---------------------------GVAHLVTADMVKPGAAVLDVGVSR 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1333636817 262 VhdpvtGKTKLVGDVDfEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14193  236 A-----GDGKLVGDVH-PDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRA 283
PRK14166 PRK14166
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-315 1.42e-75

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172654 [Multi-domain]  Cd Length: 282  Bit Score: 233.38  E-value: 1.42e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14166    9 LSAKIKEELKEKNQFLKSKG-IESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALINTLNHDD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHS-LMPATASAVWEIIKRAGIETFGKNVVVAGRSK 159
Cdd:PRK14166   88 SVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESgFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 160 NVGMPIAMLLHTDGeherpggdATVTIAHRYTpkEQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGI 239
Cdd:PRK14166  168 IVGRPMATMLLNAG--------ATVSVCHIKT--KDLSLYTRQADLIIVAA---------------------------GC 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333636817 240 PKLITSDMVKEGAAVIDVGINYVHdpvtgKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14166  211 VNLLRSDMVKEGVIVVDVGINRLE-----SGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRL 281
PLN02616 PLN02616
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 1-314 1.81e-75

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 215332 [Multi-domain]  Cd Length: 364  Bit Score: 235.67  E-value: 1.81e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PLN02616   81 VAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLKFISGFNNDP 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHS--LMPATASAVWEIIKRAGIETFGKNVVVAGRS 158
Cdd:PLN02616  161 SVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGREplFVPCTPKGCIELLHRYNVEIKGKRAVVIGRS 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 159 KNVGMPIAMLLHTDgeherpggDATVTIAHRYT--PKEQlkihTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlk 236
Cdd:PLN02616  241 NIVGMPAALLLQRE--------DATVSIVHSRTknPEEI----TREADIIISA--------------------------- 281

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333636817 237 TGIPKLITSDMVKEGAAVIDVGINYVHDPVTGKT-KLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQT 314
Cdd:PLN02616  282 VGQPNMVRGSWIKPGAVVIDVGINPVEDASSPRGyRLVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKRI 360
THF_DHG_CYH_C pfam02882
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
114-313 6.22e-73

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;


Pssm-ID: 427036  Cd Length: 160  Bit Score: 221.96  E-value: 6.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 114 HIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDgeherpggDATVTIAHRYTPk 193
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNA--------NATVTVCHSKTK- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 194 eQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVIDVGINYVhdpvtGKTKLV 273
Cdd:pfam02882  72 -DLAEITREADIVVVAV---------------------------GKPELIKADWIKPGAVVIDVGINRV-----GNGKLV 118

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1333636817 274 GDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:pfam02882 119 GDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKR 158
PRK14178 PRK14178
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 17-312 1.97e-71

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172666 [Multi-domain]  Cd Length: 279  Bit Score: 222.41  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  17 ISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVD 96
Cdd:PRK14178   20 IIESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIRRLNEDPDINGILVQLPLPKGVD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  97 ERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTdgehe 176
Cdd:PRK14178  100 TERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVVVGRSIDVGRPMAALLLN----- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 177 rpgGDATVTIAHRYTpkEQLKIHTQLADVIIVAAetlgfihktqnlnhleiivtsqwwlktGIPKLITSDMVKEGAAVID 256
Cdd:PRK14178  175 ---ADATVTICHSKT--ENLKAELRQADILVSAA---------------------------GKAGFITPDMVKPGATVID 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1333636817 257 VGINYVHDpvtgktKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:PRK14178  223 VGINQVNG------KLCGDVDFDAVKEIAGAITPVPGGVGPMTIATLMENTFDAAK 272
PRK14187 PRK14187
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 24-311 9.53e-70

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172675 [Multi-domain]  Cd Length: 294  Bit Score: 218.54  E-value: 9.53e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  24 PHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVDERTVCNG 103
Cdd:PRK14187   33 PCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEKINELNNDDSVHGILVQLPVPNHIDKNLIINT 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 104 IAPEKDVDGFHIINIGRLCLDQ--HSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHtdgeherpGGD 181
Cdd:PRK14187  113 IDPEKDVDGFHNENVGRLFTGQkkNCLIPCTPKGCLYLIKTITRNLSGSDAVVIGRSNIVGKPMACLLL--------GEN 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 182 ATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIPKLITSDMVKEGAAVIDVGINY 261
Cdd:PRK14187  185 CTVTTVHSAT--RDLADYCSKADILVAA---------------------------VGIPNFVKYSWIKKGAIVIDVGINS 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333636817 262 VHdpVTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAA 311
Cdd:PRK14187  236 IE--EGGVKKFVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAA 283
PRK14169 PRK14169
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-315 1.26e-69

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184550 [Multi-domain]  Cd Length: 282  Bit Score: 217.89  E-value: 1.26e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESwISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14169    9 VSKKILADLKQTVAK-LAQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAKVAELNHDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14169   88 DVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRVVIVGRSNI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLhtdgeherPGGDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14169  168 VGRPLAGLM--------VNHDATVTIAHSKT--RNLKQLTKEADILVVA---------------------------VGVP 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14169  211 HFIGADAVKPGAVVIDVGISRGAD-----GKLLGDVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRA 280
PRK14170 PRK14170
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-313 1.60e-69

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172658 [Multi-domain]  Cd Length: 284  Bit Score: 217.64  E-value: 1.60e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14170   10 LAKEIQEKVTREVAELVKEG-KKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSVVEELNEDK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14170   89 TIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAVVIGRSNI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDgeherpggDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14170  169 VGKPVAQLLLNE--------NATVTIAHSRT--KDLPQVAKEADILVVA---------------------------TGLA 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14170  212 KFVKKDYIKPGAIVIDVGMDRDEN-----NKLCGDVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKR 279
PRK14180 PRK14180
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 24-313 2.89e-68

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172668 [Multi-domain]  Cd Length: 282  Bit Score: 214.51  E-value: 2.89e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  24 PHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVDERTVCNG 103
Cdd:PRK14180   32 PKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 104 IAPEKDVDGFHIINIGRLCL-DQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTdgeherpgGDA 182
Cdd:PRK14180  112 IKPEKDVDGFHPTNVGRLQLrDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLLLN--------AKA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 183 TVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIPKLITSDMVKEGAAVIDVGINYV 262
Cdd:PRK14180  184 TVTTCHRFT--TDLKSHTTKADILIVA---------------------------VGKPNFITADMVKEGAVVIDVGINHV 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1333636817 263 hdpvtgKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14180  235 ------DGKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQE 279
PRK14194 PRK14194
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 23-313 1.25e-67

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172682 [Multi-domain]  Cd Length: 301  Bit Score: 213.55  E-value: 1.25e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  23 RPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVDERTVCN 102
Cdd:PRK14194   33 EPALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLLALIAELNADPSVNGILLQLPLPAHIDEARVLQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 103 GIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTdgeherpgGDA 182
Cdd:PRK14194  113 AINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGKHAVVIGRSNIVGKPMAALLLQ--------AHC 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 183 TVTIAHryTPKEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIPKLITSDMVKEGAAVIDVGINYV 262
Cdd:PRK14194  185 SVTVVH--SRSTDAKALCRQADIVVAA---------------------------VGRPRLIDADWLKPGAVVIDVGINRI 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1333636817 263 HDpvTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14194  236 DD--DGRSRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARL 284
PLN02897 PLN02897
tetrahydrofolate dehydrogenase/cyclohydrolase, putative
 3-314 1.91e-67

tetrahydrofolate dehydrogenase/cyclohydrolase, putative


Pssm-ID: 178485 [Multi-domain]  Cd Length: 345  Bit Score: 214.44  E-value: 1.91e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   3 KQIQKEIQRGVESWI-----SLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLN 77
Cdd:PLN02897   62 NVIAEEIRTKIASEVrkmkkAVG-KVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILSALRKFN 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  78 MDPRVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHS--LMPATASAVWEIIKRAGIETFGKNVVVA 155
Cdd:PLN02897  141 EDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMRGREplFVSCTPKGCVELLIRSGVEIAGKNAVVI 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 156 GRSKNVGMPIAMLLHtdgEHerpggDATVTIAHRYTPK-EQLkihTQLADVIIVAAetlgfihktqnlnhleiivtsqww 234
Cdd:PLN02897  221 GRSNIVGLPMSLLLQ---RH-----DATVSTVHAFTKDpEQI---TRKADIVIAAA------------------------ 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 235 lktGIPKLITSDMVKEGAAVIDVGINYVHDPVTG-KTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PLN02897  266 ---GIPNLVRGSWLKPGAVVIDVGTTPVEDSSCEfGYRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAKR 342


                  .
gi 1333636817 314 T 314
Cdd:PLN02897  343 I 343
PRK14171 PRK14171
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-316 3.81e-67

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172659 [Multi-domain]  Cd Length: 288  Bit Score: 211.74  E-value: 3.81e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14171   10 LANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKINELNLDN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRL--CLDQhSLMPATASAVWEIIKRAGIETFGKNVVVAGRS 158
Cdd:PRK14171   90 EISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLhsGISQ-GFIPCTALGCLAVIKKYEPNLTGKNVVIIGRS 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 159 KNVGMPIAMLLHTDgeherpggDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTG 238
Cdd:PRK14171  169 NIVGKPLSALLLKE--------NCSVTICHSKT--HNLSSITSKADIVVAA---------------------------IG 211

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333636817 239 IPKLITSDMVKEGAAVIDVGINYVhdpvtGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTLY 316
Cdd:PRK14171  212 SPLKLTAEYFNPESIVIDVGINRI-----SGNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKDSLY 284
PRK14172 PRK14172
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-306 6.85e-67

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172660 [Multi-domain]  Cd Length: 278  Bit Score: 210.79  E-value: 6.85e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14172   10 VALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEIEELNKDN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14172   90 NVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVVVIGRSNI 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTDgeherpggDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14172  170 VGKPVAQLLLNE--------NATVTICHSKT--KNLKEVCKKADILVVA---------------------------IGRP 212

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333636817 241 KLITSDMVKEGAAVIDVGINYVHDpvtgktKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKN 306
Cdd:PRK14172  213 KFIDEEYVKEGAIVIDVGTSSVNG------KITGDVNFDKVIDKASYITPVPGGVGSLTTTLLIKN 272
PRK14177 PRK14177
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-313 1.52e-66

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172665 [Multi-domain]  Cd Length: 284  Bit Score: 210.22  E-value: 1.52e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14177   11 LSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELLGVIDKLNLDP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14177   91 NVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGKNAVVVGRSPI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTdgeherpgGDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14177  171 LGKPMAMLLTE--------MNATVTLCHSKT--QNLPSIVRQADIIVGA---------------------------VGKP 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333636817 241 KLITSDMVKEGAAVIDVGINyvhdpvTGKtklVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQ 313
Cdd:PRK14177  214 EFIKADWISEGAVLLDAGYN------PGN---VGDIEISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFKE 277
PRK14181 PRK14181
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 17-307 8.19e-64

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 172669 [Multi-domain]  Cd Length: 287  Bit Score: 203.17  E-value: 8.19e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  17 ISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDPRVSGILVQLPLPDHVD 96
Cdd:PRK14181   20 ISASSTAPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIHRLNNDPNIHGILVQLPLPKHLD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  97 ERTVCNGIAPEKDVDGFHIINIGRLCLDQ-HSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHtdgeH 175
Cdd:PRK14181  100 AQAILQAISPDKDVDGLHPVNMGKLLLGEtDGFIPCTPAGIIELLKYYEIPLHGRHVAIVGRSNIVGKPLAALLM----Q 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 176 ERPGGDATVTIAHryTPKEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIPKLITSDMVKEGAAVI 255
Cdd:PRK14181  176 KHPDTNATVTLLH--SQSENLTEILKTADIIIAA---------------------------IGVPLFIKEEMIAEKAVIV 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333636817 256 DVGINYVHDPVTGKTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNT 307
Cdd:PRK14181  227 DVGTSRVPAANPKGYILVGDVDFNNVVPKCRAITPVPGGVGPMTVAMLMRNT 278
PRK14182 PRK14182
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...
 1-314 1.58e-60

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional


Pssm-ID: 172670 [Multi-domain]  Cd Length: 282  Bit Score: 194.86  E-value: 1.58e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14182    9 IAAKVKGEVATEVRALAARG-VQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIARLNADP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSL-MPATASAVWEIIKRAGIETFGKNVVVAGRSK 159
Cdd:PRK14182   88 AVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVpRPCTPAGVMRMLDEARVDPKGKRALVVGRSN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 160 NVGMPIAMLLhtdgeHERpggDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGI 239
Cdd:PRK14182  168 IVGKPMAMML-----LER---HATVTIAHSRT--ADLAGEVGRADILVAA---------------------------IGK 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333636817 240 PKLITSDMVKEGAAVIDVGINYVHDpvtgkTKLVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQT 314
Cdd:PRK14182  211 AELVKGAWVKEGAVVIDVGMNRLAD-----GKLVGDVEFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAKRT 280
PRK14192 PRK14192
bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...
 1-315 2.25e-60

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;


Pssm-ID: 184561 [Multi-domain]  Cd Length: 283  Bit Score: 194.29  E-value: 2.25e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGNRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:PRK14192   11 LAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLLAKIEELNANP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVDGFHIINIGRLCLDQHSLMPATASAVWEIIKRAGIETFGKNVVVAGRSKN 160
Cdd:PRK14192   91 DVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGKHAVVVGRSAI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 161 VGMPIAMLLHTdgeherpgGDATVTIAHRYTpkEQLKIHTQLADVIIVAaetlgfihktqnlnhleiivtsqwwlkTGIP 240
Cdd:PRK14192  171 LGKPMAMMLLN--------ANATVTICHSRT--QNLPELVKQADIIVGA---------------------------VGKP 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333636817 241 KLITSDMVKEGAAVIDVGInyvHDPVTGKtklVGDVDFEAVKRKAGFITPVPGGVGPVTVAMLLKNTLLAAKQTL 315
Cdd:PRK14192  214 ELIKKDWIKQGAVVVDAGF---HPRDGGG---VGDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEKAL 282
THF_DHG_CYH pfam00763
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;
1-111 8.28e-50

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;


Pssm-ID: 459930 [Multi-domain]  Cd Length: 115  Bit Score: 161.42  E-value: 8.28e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817   1 MAKQIQKEIQRGVESWISLGnRRPHLSIILVGDNPASHTYVRRKIRAASAVGICSEIILKPKDVSQEELLDMTDQLNMDP 80
Cdd:pfam00763   6 IAKKIREELKEEVAALKAGG-RKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDKLNADP 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1333636817  81 RVSGILVQLPLPDHVDERTVCNGIAPEKDVD 111
Cdd:pfam00763  85 SVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115
NAD_bind_m-THF_DH_Cyclohyd_like cd05212
NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...
 130-312 4.98e-17

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133451  Cd Length: 140  Bit Score: 76.39  E-value: 4.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 130 PATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGeherpggdATVTIAHRYTPKEQLKIHTqlADVIIVA 209
Cdd:cd05212     9 SPVAKAVKELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRDG--------ATVYSCDWKTIQLQSKVHD--ADVVVVG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 210 aetlgfihktqnlnhleiivtsqwwlkTGIPKLITSDMVKEGAAVIDVGINYVHDpvtgktklvgdvdfEAVKRKAGFIT 289
Cdd:cd05212    79 ---------------------------SPKPEKVPTEWIKPGATVINCSPTKLSG--------------DDVKESASLYV 117

                         170       180
                  ....*....|....*....|...
gi 1333636817 290 PVPGGVGPVTVAMLLKNTLLAAK 312
Cdd:cd05212   118 PMTGGVGKLTVAMRMQNMVRSVR 140
NAD_bind_m-THF_DH cd01079
NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...
 106-308 1.14e-07

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133447 [Multi-domain]  Cd Length: 197  Bit Score: 51.27  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 106 PEKDVDGFHIINIGRLC-----LD----QHSLMPATASAVWEIIKRAGI---------ETFGKNVVVAGRSKNVGMPIAM 167
Cdd:cd01079     1 PHKDVEGLSHKYIFNLYhnirfLDpenrKKSILPCTPLAIVKILEFLGIynkilpygnRLYGKTITIINRSEVVGRPLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 168 LLHTDGeherpggdATV-----TIAHRYTPKEQLKIHTQlaDVIIVAAETLGFIHKTqnlnhlEIIVtsqwwlkTGIPKL 242
Cdd:cd01079    81 LLANDG--------ARVysvdiNGIQVFTRGESIRHEKH--HVTDEEAMTLDCLSQS------DVVI-------TGVPSP 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333636817 243 ---ITSDMVKEGAAVIDVGinyvhdpvtgktklvGDVDFEA-VKRKAGFITPVpggVGPVTVAMLLKNTL 308
Cdd:cd01079   138 nykVPTELLKDGAICINFA---------------SIKNFEPsVKEKASIYVPS---IGKVTIAMLLRNLL 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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