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Conserved domains on  [gi|1333621919|ref|XP_023486446|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [Equus caballus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-264 2.23e-73

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 225.97  E-value: 2.23e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIIADILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYV 141
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 142 KRSAKFNEKEMRNKLQRYMNAGTPMYLVIFPEGTRYNPELTKVisaSQTFAAQEGLPVLKHVLTPRVKATHVAFDTMKSY 221
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1333621919 222 LDAIYDVTVAFEGTMddkgqrkEAPSMAEFLCKECPKIHIHID 264
Cdd:cd07990   158 VDAVYDVTIAYPDGK-------PPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 259-309 8.26e-11

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 57.58  E-value: 8.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1333621919 259 IHIHIDRIDKKDVPEEQVYMRRWLHERFEIKDKLLIEFY--DSLDPERRNKFP 309
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYetGTFFPGKEHIIP 62
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-264 2.23e-73

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 225.97  E-value: 2.23e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIIADILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYV 141
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 142 KRSAKFNEKEMRNKLQRYMNAGTPMYLVIFPEGTRYNPELTKVisaSQTFAAQEGLPVLKHVLTPRVKATHVAFDTMKSY 221
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1333621919 222 LDAIYDVTVAFEGTMddkgqrkEAPSMAEFLCKECPKIHIHID 264
Cdd:cd07990   158 VDAVYDVTIAYPDGK-------PPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-321 5.13e-49

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 169.11  E-value: 5.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  13 RCVLPAAVLLGSAPTYVLAWGAwrlLSAFLPsRFYQAVDDR-----LYCIYQSMVLFFFENYTGVQILLYGDLPKNKENI 87
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVYLAP---VSAVLL-RLFSVHYSRkatsfFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  88 IYLANHQSTVDWIIADILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNAGTPMY 167
Cdd:PLN02510   95 LLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLW 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 168 LVIFPEGTRYNPEltKVIsASQTFAAQEGLPVLKHVLTPRVKATHVAFDTMKSYLDAIYDVTVAFegtmddkgqRKEAPS 247
Cdd:PLN02510  175 LALFPEGTDYTEA--KCQ-RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGY---------KHRCPS 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333621919 248 MAEFLCKECP-KIHIHIDRIDKKDVPEEQVYMRRWLHERFEIKDKLLIEFYdsldpeRRNKFPGKSVNSKLSLKK 321
Cdd:PLN02510  243 FLDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY------AQGHFPNEGTEGELSTLK 311
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-212 2.13e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 82.79  E-value: 2.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919   87 IIYLANHQSTVDWIIadILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNAGTPm 166
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEW- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1333621919  167 yLVIFPEGTRYNPELTKvisASQTFAAQEGLpVLKHVLTPRVKATH 212
Cdd:smart00563  78 -LLIFPEGTRSRPGKLL---PFKKGAARLAL-EAGVPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-176 9.73e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 69.65  E-value: 9.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  36 RLLSAFLPSRFYQAVddRLYCiyqSMVLFFFenYTGVQILLYGDLPKNKeNIIYLANHQSTVDWIIAdILAIRQnalgHV 115
Cdd:COG0204     2 RSLFLLLRRFRYRLV--RLWA---RLLLRLL--GVRVRVEGLENLPADG-PVLIVANHQSWLDILLL-LAALPR----PV 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333621919 116 RYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNAGTPmyLVIFPEGTR 176
Cdd:COG0204    69 RFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES--LVIFPEGTR 127
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-176 9.77e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 61.91  E-value: 9.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  83 NKENIIYLANHQSTVDWIIADILAIRQNALghVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNA 162
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLRE 89

                          90
                  ....*....|....
gi 1333621919 163 GtpMYLVIFPEGTR 176
Cdd:pfam01553  90 G--KLVVIFPEGTR 101
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 259-309 8.26e-11

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 57.58  E-value: 8.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1333621919 259 IHIHIDRIDKKDVPEEQVYMRRWLHERFEIKDKLLIEFY--DSLDPERRNKFP 309
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYetGTFFPGKEHIIP 62
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 4.07e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 54.27  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  71 GVQILLYG--DLPKnKENIIYLANHQSTVDwIIADILAIRQNalghVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFN 148
Cdd:TIGR00530   1 GLKVEVVGpeNLPA-KSPVLVVANHQSNLD-PLTLSAAFPPP----IVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRA 74

                          90       100
                  ....*....|....*....|....*...
gi 1333621919 149 EKEMRNKLQRYMNAGTPmyLVIFPEGTR 176
Cdd:TIGR00530  75 IATALKAAIEVLKQGRS--IGVFPEGTR 100
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-264 2.23e-73

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 225.97  E-value: 2.23e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIIADILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYV 141
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 142 KRSAKFNEKEMRNKLQRYMNAGTPMYLVIFPEGTRYNPELTKVisaSQTFAAQEGLPVLKHVLTPRVKATHVAFDTMKSY 221
Cdd:cd07990    81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1333621919 222 LDAIYDVTVAFEGTMddkgqrkEAPSMAEFLCKECPKIHIHID 264
Cdd:cd07990   158 VDAVYDVTIAYPDGK-------PPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-321 5.13e-49

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 169.11  E-value: 5.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  13 RCVLPAAVLLGSAPTYVLAWGAwrlLSAFLPsRFYQAVDDR-----LYCIYQSMVLFFFENYTGVQILLYGDLPKNKENI 87
Cdd:PLN02510   19 RGLICLLVLLSTAFMMLVYLAP---VSAVLL-RLFSVHYSRkatsfFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  88 IYLANHQSTVDWIIADILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNAGTPMY 167
Cdd:PLN02510   95 LLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLW 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 168 LVIFPEGTRYNPEltKVIsASQTFAAQEGLPVLKHVLTPRVKATHVAFDTMKSYLDAIYDVTVAFegtmddkgqRKEAPS 247
Cdd:PLN02510  175 LALFPEGTDYTEA--KCQ-RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGY---------KHRCPS 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1333621919 248 MAEFLCKECP-KIHIHIDRIDKKDVPEEQVYMRRWLHERFEIKDKLLIEFYdsldpeRRNKFPGKSVNSKLSLKK 321
Cdd:PLN02510  243 FLDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY------AQGHFPNEGTEGELSTLK 311
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 42-296 4.31e-43

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 153.36  E-value: 4.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  42 LPSRFYQAVDDRLYCIYQSMVLFFFENYTGVQILLYGDLPK----NKENIIYLANHQSTVDWIIADILAIRQNALGHVRY 117
Cdd:PLN02380   37 LSKSLYRRINRAVAELLWLELIWLVDWWAGVKVQLYADEETfelmGKEHALVISNHRSDIDWLVGWILAQRSGCLGSALA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 118 VLKDGLKWLPLYG--CYFSQHggIYVKRSAKFNEKEMRNKLQRYMNAGTPMYLVIFPEGTRYNPEltkVISASQTFAAQE 195
Cdd:PLN02380  117 VMKKSSKFLPVIGwsMWFSEY--VFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQA---KLLAAQEYAASR 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 196 GLPVLKHVLTPRVKATHVAFDTMKSYLDAIYDVTVAFegtmdDKGQRkeAPSMAEFLCKECPKIHIHIDRIDKKDVPEEQ 275
Cdd:PLN02380  192 GLPVPRNVLIPRTKGFVSAVSNMRSFVPAIYDVTVAV-----PKGQP--APTMLRIFRGQSSVVHVHIKRHSMKELPETD 264

                         250       260
                  ....*....|....*....|.
gi 1333621919 276 VYMRRWLHERFEIKDKLLIEF 296
Cdd:PLN02380  265 DGIAQWCKDVFVAKDALLDKH 285
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-212 2.13e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 82.79  E-value: 2.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919   87 IIYLANHQSTVDWIIadILAIRQNALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNAGTPm 166
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEW- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1333621919  167 yLVIFPEGTRYNPELTKvisASQTFAAQEGLpVLKHVLTPRVKATH 212
Cdd:smart00563  78 -LLIFPEGTRSRPGKLL---PFKKGAARLAL-EAGVPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-176 9.73e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 69.65  E-value: 9.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  36 RLLSAFLPSRFYQAVddRLYCiyqSMVLFFFenYTGVQILLYGDLPKNKeNIIYLANHQSTVDWIIAdILAIRQnalgHV 115
Cdd:COG0204     2 RSLFLLLRRFRYRLV--RLWA---RLLLRLL--GVRVRVEGLENLPADG-PVLIVANHQSWLDILLL-LAALPR----PV 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1333621919 116 RYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNAGTPmyLVIFPEGTR 176
Cdd:COG0204    69 RFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES--LVIFPEGTR 127
PRK14014 PRK14014
putative acyltransferase; Provisional
 89-293 4.99e-13

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 68.72  E-value: 4.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  89 YL--ANHQStvdWiiADILAIRQNALGHV---RYVLKDGLKWLPLYG--CYF------SQHGGIYVKRSAKFNEKEMRN- 154
Cdd:PRK14014   89 YLviSNHQS---W--VDILVLQYVFNRRIpmlKFFLKQELIWVPFLGlaWWAldfpfmKRYSKAYLAKNPELKGKDLETt 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 155 -----KLQRymnagTPMYLVIFPEGTRYNPEltKvisasqtfAAQEGLPvLKHVLTPrvKATHVAF--DTMKSYLDAIYD 227
Cdd:PRK14014  164 rraceKFKR-----MPTTIVNFVEGTRFTPE--K--------HQQQQSP-YQHLLKP--KAGGIAFalNAMGEQFDGLLD 225

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1333621919 228 VTVAFEGtmddkgqrkEAPSMAEFLCKECPKIHIHIDRIdkkDVPEE-----------QVYMRRWLHERFEIKDKLL 293
Cdd:PRK14014  226 VTIVYPD---------GRPSFWDLLSGRVKKIVVHVRLL---PIPEEligdyfndkefRRRFQQWLNQLWQEKDQLI 290
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 82-200 1.46e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 65.37  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  82 KNKENI------IYLANHQSTVDWIIadILAIrqnALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNK 155
Cdd:cd07989    15 EGLENLppkgpvIIVANHQSYLDPLV--LGAA---LPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREALRE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1333621919 156 LQRYMNAGTPmyLVIFPEGTR-YNPELTKVISASQTFAAQEGLPVL 200
Cdd:cd07989    90 AIEALKEGES--VVIFPEGTRsRDGELLPFKSGAFRLAKEAGVPIV 133
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-176 9.77e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 61.91  E-value: 9.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  83 NKENIIYLANHQSTVDWIIADILAIRQNALghVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQRYMNA 162
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLRE 89

                          90
                  ....*....|....
gi 1333621919 163 GtpMYLVIFPEGTR 176
Cdd:pfam01553  90 G--KLVVIFPEGTR 101
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 259-309 8.26e-11

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 57.58  E-value: 8.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1333621919 259 IHIHIDRIDKKDVPEEQVYMRRWLHERFEIKDKLLIEFY--DSLDPERRNKFP 309
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYetGTFFPGKEHIIP 62
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 4.07e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 54.27  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  71 GVQILLYG--DLPKnKENIIYLANHQSTVDwIIADILAIRQNalghVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFN 148
Cdd:TIGR00530   1 GLKVEVVGpeNLPA-KSPVLVVANHQSNLD-PLTLSAAFPPP----IVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRA 74

                          90       100
                  ....*....|....*....|....*...
gi 1333621919 149 EKEMRNKLQRYMNAGTPmyLVIFPEGTR 176
Cdd:TIGR00530  75 IATALKAAIEVLKQGRS--IGVFPEGTR 100
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 78-175 1.31e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 48.76  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  78 GDLPKNKENIIYLANHQSTVDWIIADILairqnalGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNEKEMRNKLQ 157
Cdd:cd07991    17 GKPDPPEAPRIIVANHTSFIDPLILFSD-------LFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIK 89

                          90
                  ....*....|....*...
gi 1333621919 158 RYMNAGTPMYLVIFPEGT 175
Cdd:cd07991    90 ERATDPNWPPILIFPEGT 107
PLN02833 PLN02833
glycerol acyltransferase family protein
 29-182 4.22e-05

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 45.15  E-value: 4.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  29 VLAWGAWRLLSAFLPSRFYQAVDDRLY----CIYQSMVLFFFENYTGVqILLYGDLPKNKENIIYLANHQSTVDWIIADI 104
Cdd:PLN02833  104 LLAIGWIIFLSAFIPVHFLLKGHKLRKkierKLVELICSAFVASWTGV-IKYHGPRPSRRPKQVFVANHTSMIDFIVLEQ 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919 105 L----AIRQNALGHVRYVLKDGLKWLplyGCyfsqhggIYVKRSaKFNEKEM-RNKLQRYMNAGTPMYLVIFPEGTRYNP 179
Cdd:PLN02833  183 MtpfaVIMQKHPGWVGFLQNTILESV---GC-------IWFNRT-EAKDREVvAKKLRDHVQDPDRNPLLIFPEGTCVNN 251


                  ...
gi 1333621919 180 ELT 182
Cdd:PLN02833  252 EYT 254
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 78-176 3.24e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 40.66  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333621919  78 GDLPKNKENIIYLANHQSTVDWIIAdILAIRQNALGhVRYVLKDGLKWLPLyGCYFSQHGGIYVKRSAKFNE-KEMRNKL 156
Cdd:cd07988    14 GEPPNKPKFVVIGAPHTSNWDFVLG-LLAAFALGLK-ISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAGGLvEQVVEEF 90

                          90       100
                  ....*....|....*....|
gi 1333621919 157 QRYmnagTPMYLVIFPEGTR 176
Cdd:cd07988    91 RRR----EEFVLAIAPEGTR 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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