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Conserved domains on  [gi|1333583957|ref|XP_023476870|]
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TSC22 domain family protein 2 isoform X2 [Equus caballus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
 672-734 5.26e-38

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


:

Pssm-ID: 409279  Cd Length: 63  Bit Score: 135.48  E-value: 5.26e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 672 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPAQQANPGST 734
Cdd:cd21939     1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 380-611 8.37e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 8.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  380 QPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPA----GGPPAAVGGAG 455
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaaGPPRRLTRPAV 2788

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  456 PPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPnvPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQ-----LSSHTPVSRSG 530
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALP--PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggsVAPGGDVRRRP 2866

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  531 GSIPHVGLPVAQGTASApTSLPQPDLSQfQTHTQPLvgqiddTRRKSEPLPQPPLSIAAETKPVVKPPVADALANPLQLT 610
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPV-RRLARPAVSR-STESFAL------PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938


                   .
gi 1333583957  611 P 611
Cdd:PHA03247  2939 P 2939
 
Name Accession Description Interval E-value
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
 672-734 5.26e-38

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409279  Cd Length: 63  Bit Score: 135.48  E-value: 5.26e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 672 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPAQQANPGST 734
Cdd:cd21939     1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
TSC22 pfam01166
TSC-22/dip/bun family;
673-729 7.48e-30

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 112.02  E-value: 7.48e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333583957 673 MDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPAQQA 729
Cdd:pfam01166   1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPEQLEQLSSQLQ 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 380-611 8.37e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 8.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  380 QPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPA----GGPPAAVGGAG 455
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaaGPPRRLTRPAV 2788

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  456 PPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPnvPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQ-----LSSHTPVSRSG 530
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALP--PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggsVAPGGDVRRRP 2866

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  531 GSIPHVGLPVAQGTASApTSLPQPDLSQfQTHTQPLvgqiddTRRKSEPLPQPPLSIAAETKPVVKPPVADALANPLQLT 610
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPV-RRLARPAVSR-STESFAL------PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938


                   .
gi 1333583957  611 P 611
Cdd:PHA03247  2939 P 2939
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 407-519 4.87e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 43.52  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 407 SAASAGAQVMGAPTLPGDAVapgPGPSQGgqaAPGQPAGGPPAAVGGAG---PPLSVPQPqmvgggVPPAGPSGPLAVVP 483
Cdd:TIGR01645 304 AAAAATAKIMAAEAVAGAAV---LGPRAQ---SPATPSSSLPTDIGNKAvvsSAKKEAEE------VPPLPQAAPAVVKP 371

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1333583957 484 GVPNVPAAVPAPSVP---SVSTTSVTMPNVPAPLVQSQQ 519
Cdd:TIGR01645 372 GPMEIPTPVPPPGLAipsLVAPPGLVAPTEINPSFLASP 410
PRK13169 PRK13169
DNA replication initiation control protein YabA;
686-737 3.63e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 37.92  E-value: 3.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333583957 686 EEVEVLKEQIKELVERNSLLERENALLKslsnsDQLSQLPAQQANPGSTSQQ 737
Cdd:PRK13169   22 KELGALKKQLAELLEENTALRLENDKLR-----ERLEELEAEEPAKEKKKKE 68
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 403-593 8.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 403 GPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMV----GGGVPPAGPSGP 478
Cdd:pfam05109 465 GPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTtptpNATSPTLGKTSP 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 479 L-AVVPGVPNVPAAVPAPSVPSvsttsvtmPNVPAPLVQSQQLSSHTPVSRSGGSIPHVGLPVAQ---------GTASAP 548
Cdd:pfam05109 545 TsAVTTPTPNATSPTPAVTTPT--------PNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQanttnhtlgGTSSTP 616

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1333583957 549 --TSLPQPDLSQFQThtqplvGQIDDTRRKSEPLPQPPLSIAAETKP 593
Cdd:pfam05109 617 vvTSPPKNATSAVTT------GQHNITSSSTSSMSLRPSSISETLSP 657
 
Name Accession Description Interval E-value
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
 672-734 5.26e-38

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409279  Cd Length: 63  Bit Score: 135.48  E-value: 5.26e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 672 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPAQQANPGST 734
Cdd:cd21939     1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
ZIP_TSC22D4 cd21941
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 ...
 663-728 5.11e-30

leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 (TSC22D4), also called TSC22-related-inducible leucine zipper protein 2 (TILZ2), or Tsc-22-like protein THG-1, is a transcriptional repressor that acts as a molecular determinant of insulin signalling and glucose handling. It also functions in hepatic lipid handling by regulating hepatic very-low-density-lipoprotein (VLDL) release and lipogenic gene expression. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D4. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409281  Cd Length: 74  Bit Score: 113.11  E-value: 5.11e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333583957 663 VAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPAQQ 728
Cdd:cd21941     1 VAIDNKIEQAMDLVKSHLLFAVREEVEVLKEQIKELSERNAALEQENSLLRSLATPQQLSRLQSRQ 66
TSC22 pfam01166
TSC-22/dip/bun family;
673-729 7.48e-30

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 112.02  E-value: 7.48e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333583957 673 MDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPAQQA 729
Cdd:pfam01166   1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPEQLEQLSSQLQ 57
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 668-738 6.65e-27

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409278  Cd Length: 79  Bit Score: 104.45  E-value: 6.65e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 668 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQLSQLPA--QQANPGSTSQQQ 738
Cdd:cd21938     1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAqlQTGSPPSSSQPP 73
ZIP_TSC22D cd21936
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ...
 672-720 1.34e-26

leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409276  Cd Length: 49  Bit Score: 102.64  E-value: 1.34e-26
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1333583957 672 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQ 720
Cdd:cd21936     1 AMDLVKSHLMFAVREEVDVLKEQIAELEERISQLERENSLLRSNAPPEV 49
ZIP_TSC22D3 cd21940
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 ...
 672-731 7.21e-24

leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409280  Cd Length: 81  Bit Score: 95.79  E-value: 7.21e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1333583957 672 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNSDQL----SQLPAQQANP 731
Cdd:cd21940     1 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLERENSLLKTLASPEQLekfqSRLPSEETAP 64
ZIP_TSC22D-like cd21927
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding ...
 673-720 1.50e-17

leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins; The family includes TGF-beta-stimulated clone-22 domain (TSC22D) leucine zipper transcription factors, TSC22D1-4, as well as c-Myc-binding protein (MycBP). TSC22D proteins have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. Members of this family contain a conserved leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409275  Cd Length: 51  Bit Score: 76.79  E-value: 1.50e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333583957 673 MDLVKSHLMYAVREE--VEVLKEQIKELVERNSLLERENALLKSLSNSDQ 720
Cdd:cd21927     2 LDFLKHHLGAATPENpeIELLRLELAEMKEKYEAIVEENKKLKAKLAQYE 51
PHA03247 PHA03247
large tegument protein UL36; Provisional
 380-611 8.37e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 8.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  380 QPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPA----GGPPAAVGGAG 455
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaaGPPRRLTRPAV 2788

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  456 PPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPnvPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQ-----LSSHTPVSRSG 530
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALP--PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggsVAPGGDVRRRP 2866

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  531 GSIPHVGLPVAQGTASApTSLPQPDLSQfQTHTQPLvgqiddTRRKSEPLPQPPLSIAAETKPVVKPPVADALANPLQLT 610
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPV-RRLARPAVSR-STESFAL------PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938


                   .
gi 1333583957  611 P 611
Cdd:PHA03247  2939 P 2939
PHA03247 PHA03247
large tegument protein UL36; Provisional
 230-604 1.18e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  230 AHGPDSGTDSSLTAVSQLPPSERMGQP-----AAAPPQSFGVGQPPPPVGGAVAPGSAPPPPFPGAAAgppplmaalqPS 304
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLgraaqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----------PH 2713

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  305 QLQGSGPAVGPPGPGGQALPLPPVALAQPGLAVGAPAPQPPPPFAYPQpqlppphllpgAPSGqseylqqhvvglqPPSP 384
Cdd:PHA03247  2714 ALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP-----------TTAG-------------PPAP 2769

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  385 AQPSAAGASPAAAASLpvgPGQSAASAGAQVMGAPTLPGD--AVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLS--V 460
Cdd:PHA03247  2770 APPAAPAAGPPRRLTR---PAVASLSESRESLPSPWDPADppAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPgpP 2846

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  461 PQPQMVGGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTpvsrsggsiphvglPV 540
Cdd:PHA03247  2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQ--------------PQ 2912

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1333583957  541 AQGTASAPTSLPQPDLSQFQTHTQPlvgqiddtRRKSEPLPQPPLSIAAETKPVVKPPVADALA 604
Cdd:PHA03247  2913 APPPPQPQPQPPPPPQPQPPPPPPP--------RPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
PHA03247 PHA03247
large tegument protein UL36; Provisional
 240-606 1.42e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  240 SLTAVSQLPPSERMGQPAAaPPQSFGVGQPPPPVGGAVAPGSAPPPpfpgaAAGPPPLMAALQPSQLQGSGPAVGPPGPG 319
Cdd:PHA03247  2694 SLTSLADPPPPPPTPEPAP-HALVSATPLPPGPAAARQASPALPAA-----PAPPAVPAGPATPGGPARPARPPTTAGPP 2767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  320 GQALPLPPVALAQPGLAVGAPAPQPPPPFAYPQPQLPPPHLLPGAPSGQSEYLQQHVVGLQPPSPAQPSAAGASPAAAAS 399
Cdd:PHA03247  2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  400 LPVGPGQSAASAG-----------AQVMGAPTLPGDAVAPGPGPSQG---------GQAAPGQPAGGPPAAVGGAGPPLS 459
Cdd:PHA03247  2848 PSLPLGGSVAPGGdvrrrppsrspAAKPAAPARPPVRRLARPAVSRStesfalppdQPERPPQPQAPPPPQPQPQPPPPP 2927

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  460 VPQPQMVGGGVPPAgPSGPLAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNV----PAPLVQSQQLSSHTPVSR--SGGSI 533
Cdd:PHA03247  2928 QPQPPPPPPPRPQP-PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrvpqPAPSREAPASSTPPLTGHslSRVSS 3006

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333583957  534 PHVGLPVAQGTASAPTSLPQ----PDLSQFQTHTQPLVGQIDDTRRKS-EPLPQPPLSIAAEtKPVVKPPVADALANP 606
Cdd:PHA03247  3007 WASSLALHEETDPPPVSLKQtlwpPDDTEDSDADSLFDSDSERSDLEAlDPLPPEPHDPFAH-EPDPATPEAGARESP 3083
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 405-513 3.95e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 50.45  E-value: 3.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 405 GQSAASAGAQVMGAPTLPGDAVAPGPGpSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVVPG 484
Cdd:PRK14959  375 GGGASAPSGSAAEGPASGGAATIPTPG-TQGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPWDDAPPAPPRSGIPPRPA 453

                          90       100       110
                  ....*....|....*....|....*....|
gi 1333583957 485 vPNVPAAVPAPSVP-SVSTTSVTMPNVPAP 513
Cdd:PRK14959  454 -PRMPEASPVPGAPdSVASASDAPPTLGDP 482
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 408-606 4.44e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 408 AASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPN 487
Cdd:PRK07764  375 LARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAP 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 488 VPAAVPAPSVPSVSTTSVTMPNVPAPlvQSQQLSSHTPVsrsggsiphvglPVAQGTASAPTSLPQPDLSQFQTHTQPLV 567
Cdd:PRK07764  455 SPPPAAAPSAQPAPAPAAAPEPTAAP--APAPPAAPAPA------------AAPAAPAAPAAPAGADDAATLRERWPEIL 520

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1333583957 568 GQIDDTRRKSEPLPQPPLSIAAETKPVV-----KPPVADALANP 606
Cdd:PRK07764  521 AAVPKRSRKTWAILLPEATVLGVRGDTLvlgfsTGGLARRFASP 564
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
427-606 5.13e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 5.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 427 APGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPSVSTTSVT 506
Cdd:PRK07003  361 AVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGD 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 507 MPNVPAPLVQSQQLSSHTPVSRSGGSIPHVGLPVAQGTASAPTSLPQPdlsqfQTHTQPLVGQIDDTRRKSEPLPQPPLS 586
Cdd:PRK07003  441 DAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDA-----AFEPAPRAAAPSAATPAAVPDARAPAA 515

                         170       180
                  ....*....|....*....|
gi 1333583957 587 IAAETKPVVKPPVADALANP 606
Cdd:PRK07003  516 ASREDAPAAAAPPAPEARPP 535
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 376-609 2.64e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 376 VVGLQPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAqvmgaPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAG 455
Cdd:PRK07764  587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAP-----AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPD 661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 456 PPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTPVSRSGGSIPH 535
Cdd:PRK07764  662 ASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1333583957 536 VGLPVAQGTASAPTSLPQPDLSQFQTHTQPlvgqiddTRRKSEPLPQPPLSIAAETKPVVKPPVADALANPLQL 609
Cdd:PRK07764  742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPA-------AAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMEL 808
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 324-501 4.80e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 324 PLPPVALAQPGlAVGAPAPQPPPPFAYPQPQLPPPHLLPGAPSGQSEYLQQHVVGLQPPSPAQPSAAGASPAAAASLPVG 403
Cdd:PRK07764  606 SGPPEEAARPA-APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 404 PGQSAASAGAQVMGAPTLPGDAVAPGPGPSQ---GGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLA 480
Cdd:PRK07764  685 PAPAAPAAPAGAAPAQPAPAPAATPPAGQADdpaAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAP 764

                         170       180
                  ....*....|....*....|.
gi 1333583957 481 VVPGVPNVPAAVPAPSVPSVS 501
Cdd:PRK07764  765 APAAAPAAAPPPSPPSEEEEM 785
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
 672-724 5.50e-05

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 41.38  E-value: 5.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1333583957 672 AMDLVKSHL--MYAVREEVEVLKEQIKELVERNSLLERENALLKSlsnsdQLSQL 724
Cdd:cd21937     3 ALDFIKQHLgaPGPEDADVEALRLENEELKQKNEELEEENKELKA-----KLQQY 52
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 408-500 8.42e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.86  E-value: 8.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 408 AASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQ-PAGGPPAAVGGAGPPLSVPQPqmvgggvPPAGPSGPLAVVPGVP 486
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPaPAAAPAAAASAPAAPPAAAPP-------APVAAPAAAAPAAAPA 439

                          90
                  ....*....|....
gi 1333583957 487 NVPAAVPAPSVPSV 500
Cdd:PRK14951  440 AAPAAVALAPAPPA 453
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 408-601 9.75e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 9.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 408 AASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVV----- 482
Cdd:PRK07764  586 AVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPdasdg 665

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 483 PGVPNVPAAVPAPSVPSVSTTSvTMPNVPAPLVQSQQLSSHTPVSRSGGSIPHVGLPVAQGTASAPTslpqpdlSQFQTH 562
Cdd:PRK07764  666 GDGWPAKAGGAAPAAPPPAPAP-AAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP-------SPAADD 737

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1333583957 563 TQPLVGQIDDTRRKSEPL--PQPPLSIAAETKPVVKPPVAD 601
Cdd:PRK07764  738 PVPLPPEPDDPPDPAGAPaqPPPPPAPAPAAAPAAAPPPSP 778
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 363-513 1.77e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 363 GAPSGQSEYlqqhvVGLQPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQ 442
Cdd:PRK07764  631 GAAAAPAEA-----SAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 443 PAGGPPAavgGAGPPLSVPQPQMVGGGVPPAGPSG--PLAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAP 513
Cdd:PRK07764  706 AATPPAG---QADDPAAQPPQAAQGASAPSPAADDpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 363-555 4.20e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 363 GAPSGQSEYLQQHVVGLQPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAQVMG---APTLPGDAVAPGPGPSQGGQAA 439
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgvAAPEHHPKHVAVPDASDGGDGW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 440 PGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPNVPAAvPAPSVPSVSTTSVTMPNVPAPLVQSQQ 519
Cdd:PRK07764  670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQP-PQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1333583957 520 LSSHTPvSRSGGSIPHVGLPVAQGTASAPTSLPQPD 555
Cdd:PRK07764  749 PDPAGA-PAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 407-519 4.87e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 43.52  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 407 SAASAGAQVMGAPTLPGDAVapgPGPSQGgqaAPGQPAGGPPAAVGGAG---PPLSVPQPqmvgggVPPAGPSGPLAVVP 483
Cdd:TIGR01645 304 AAAAATAKIMAAEAVAGAAV---LGPRAQ---SPATPSSSLPTDIGNKAvvsSAKKEAEE------VPPLPQAAPAVVKP 371

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1333583957 484 GVPNVPAAVPAPSVP---SVSTTSVTMPNVPAPLVQSQQ 519
Cdd:TIGR01645 372 GPMEIPTPVPPPGLAipsLVAPPGLVAPTEINPSFLASP 410
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
298-532 6.32e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 6.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 298 MAALQPSQLQGSGPAVGPPGPGGQALPLP-PVALAQPGLAVgapapqppppfaypqpqLPPPHLLPGAPSGqseylqqhv 376
Cdd:PRK07003  355 MLAFEPAVTGGGAPGGGVPARVAGAVPAPgARAAAAVGASA-----------------VPAVTAVTGAAGA--------- 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 377 vglqPPSPAQPSAAGASPAAAASLPVGPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPgQPaggPPAAVGGAGP 456
Cdd:PRK07003  409 ----ALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDA-QP---PADSGSASAP 480

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333583957 457 PLSVPQPQMVGGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPSvsttsvtMPNVPAPLVQSQQLSSHTPVSRSGGS 532
Cdd:PRK07003  481 ASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPA-------AAAPPAPEARPPTPAAAAPAARAGGA 549
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
408-552 7.30e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 7.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 408 AASAGAQVMGA--PTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLA----- 480
Cdd:PRK07003  361 AVTGGGAPGGGvpARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATadrgd 440

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 481 -VVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTPVSRSGGSIPHVGLPVAQGTASAPTSLP 552
Cdd:PRK07003  441 dAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAP 513
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 380-499 7.69e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 380 QPPSPAQPSAAGASPAAAAslpvgPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLS 459
Cdd:PRK07764  392 GAPAAAAPSAAAAAPAAAP-----APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQP 466

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1333583957 460 VPQPQmvgGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPS 499
Cdd:PRK07764  467 APAPA---AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 407-599 1.05e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  407 SAASAGAQVMGAPTLPGDAVAPGPGPSQGGQ--AAPGQPAGGP--PAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVV 482
Cdd:PRK10263   324 AAATTATQSWAAPVEPVTQTPPVASVDVPPAqpTVAWQPVPGPqtGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQP 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  483 PGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTPvsrsggsiphvglpvAQGTASAPTSLPQPDLSQFQTH 562
Cdd:PRK10263   404 QQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNA---------------WQAEEQQSTFAPQSTYQTEQTY 468

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1333583957  563 TQPLVGqiDDTRRKSEPLPQP----PLSIAAETKPvVKPPV 599
Cdd:PRK10263   469 QQPAAQ--EPLYQQPQPVEQQpvvePEPVVEETKP-ARPPL 506
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 467-590 1.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 467 GGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNV----PAPLVQSQQLSSHTPVSRSGGSIPHVGlPVAQ 542
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAasapAAPPAAAPPAPVAAPAAAAPAAAPAAA-PAAV 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1333583957 543 GTASAPTSLPQPDLSQFQTHTQPLVGQiDDTRRKSEPLPQPPLSIAAE 590
Cdd:PRK14951  446 ALAPAPPAQAAPETVAIPVRVAPEPAV-ASAAPAPAAAPAAARLTPTE 492
PRK12438 PRK12438
hypothetical protein; Provisional
 402-492 1.69e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.77  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 402 VGPGQSAASAGAQVMGAPTlpgDAVAPGPGpsqgGQAAPGQPAGGPPAAVGGAGPPLSVPQPQmvggGVPPAGPSGPLAV 481
Cdd:PRK12438  881 VGYAPTLAEALDQVFGPGT---GRVATAPG----GDAASAPPPGAGPPAPPQAVPPPRTTQPP----AAPPRGPDVPPAA 949

                          90
                  ....*....|.
gi 1333583957 482 VPGVPNVPAAV 492
Cdd:PRK12438  950 VAELRETLADL 960
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 326-500 1.70e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 326 PPVALAQPGLAVGAPAPQPPPPFAYPQPQLPPPHLLPGAPSGQSEYLQQHVVGLQPPSPAQPSAAGASPAAAASLPVGPG 405
Cdd:PRK07764  620 APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 406 QSAASAGAQVMGAPtlPGDAVAPGPGPSQGGQAAPGQPAGG------PPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPL 479
Cdd:PRK07764  700 QPAPAPAATPPAGQ--ADDPAAQPPQAAQGASAPSPAADDPvplppePDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPS 777

                         170       180
                  ....*....|....*....|.
gi 1333583957 480 AVVPGVPNVPAAVPAPSVPSV 500
Cdd:PRK07764  778 PPSEEEEMAEDDAPSMDDEDR 798
PHA02030 PHA02030
hypothetical protein
 402-500 2.24e-03

hypothetical protein


Pssm-ID: 222843 [Multi-domain]  Cd Length: 336  Bit Score: 41.12  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 402 VGPGQSAASAGAQVMGAPTLPGDAVAPgpgPSQGGQAAPGQPAggPPAAVGGAGPPLsvpqPQMVGGGVPPAGPSGPLAV 481
Cdd:PHA02030  247 LGGGEDLIIKPKSKAAGSNLPAVPNVA---ADAGSAAAPAVPA--AAAAVAQAAPSV----PQVPNVAVLPDVPQVAPVA 317

                          90
                  ....*....|....*....
gi 1333583957 482 VPGVPNVPAAVPAPSVPSV 500
Cdd:PHA02030  318 APAAPEVPAVPVVPAAPQV 336
PRK13169 PRK13169
DNA replication initiation control protein YabA;
686-737 3.63e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 37.92  E-value: 3.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333583957 686 EEVEVLKEQIKELVERNSLLERENALLKslsnsDQLSQLPAQQANPGSTSQQ 737
Cdd:PRK13169   22 KELGALKKQLAELLEENTALRLENDKLR-----ERLEELEAEEPAKEKKKKE 68
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
331-582 3.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 331 AQPGLAVGAPAPQPPPPFAYPQPQLPPPHLLPGAPsgqseylqqhvvglqPPSPAQPSAAGASPAAAASLPVGPGQSAAS 410
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAP---------------AAAPAAAAAARAVAAAPARRSPAPEALAAA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 411 AGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPNVPA 490
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDA 516

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 491 AVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTPVSRSGGSIPHVGLPVAQGTASAPT-----------SLPQPDLSQF 559
Cdd:PRK12323  517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDmfdgdwpalaaRLPVRGLAQQ 596

                         250       260
                  ....*....|....*....|...
gi 1333583957 560 QTHTQPLVGQIDDTRRKSEPLPQ 582
Cdd:PRK12323  597 LARQSELAGVEGDTVRLRVPVPA 619
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 383-499 6.65e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 6.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 383 SPAQPSAAGASPAAAASLPVGPGQSAASAGAQVmgAPTLPGDAVAPGPgPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQ 462
Cdd:PRK14951  380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAAS--APAAPPAAAPPAP-VAAPAAAAPAAAPAAAPAAVALAPAPPAQAA 456

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1333583957 463 PQMVggGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPS 499
Cdd:PRK14951  457 PETV--AIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 403-534 8.64e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 39.49  E-value: 8.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957  403 GPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQggQAAPGQPAGGPPAAvggagPPLSVPQPqmvgggVPPAGPSGPLAvv 482
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPA--APAPAPPAAAAPAA-----PPKPAAAA------AAAAAPAAPPA-- 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1333583957  483 pgvpnvPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTPVSRSGGSIP 534
Cdd:PRK12270   102 ------AAAAAAPAAAAVEDEVTPLRGAAAAVAKNMDASLEVPTATSVRAVP 147
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 448-600 8.79e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.46  E-value: 8.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 448 PAAVGGAgPPLSVPQPQMVGGGVPPAGPSGPLAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLVQSQQLSSHTPVS 527
Cdd:PRK07994  361 PAAPLPE-PEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAK 439

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1333583957 528 RSggsiphvgLPVAQGTAsAPTSLPQPDLSQFQTHTQPLVGQIDdtrrKSEPLPQPPLSIAAETKPVVKPPVA 600
Cdd:PRK07994  440 KS--------EPAAASRA-RPVNSALERLASVRPAPSALEKAPA----KKEAYRWKATNPVEVKKEPVATPKA 499
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 403-593 8.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 403 GPGQSAASAGAQVMGAPTLPGDAVAPGPGPSQGGQAAPGQPAGGPPAAVGGAGPPLSVPQPQMV----GGGVPPAGPSGP 478
Cdd:pfam05109 465 GPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTtptpNATSPTLGKTSP 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333583957 479 L-AVVPGVPNVPAAVPAPSVPSvsttsvtmPNVPAPLVQSQQLSSHTPVSRSGGSIPHVGLPVAQ---------GTASAP 548
Cdd:pfam05109 545 TsAVTTPTPNATSPTPAVTTPT--------PNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQanttnhtlgGTSSTP 616

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1333583957 549 --TSLPQPDLSQFQThtqplvGQIDDTRRKSEPLPQPPLSIAAETKP 593
Cdd:pfam05109 617 vvTSPPKNATSAVTT------GQHNITSSSTSSMSLRPSSISETLSP 657
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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