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Conserved domains on  [gi|1333551226|ref|XP_023473481|]
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N-acetylgalactosamine kinase isoform X4 [Equus caballus]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 11-373 3.16e-103

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 313.57  E-value: 3.16e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 164 LGMNLSK-----------------------------------------------------------LLAKSK-------- 176
Cdd:PLN02521  182 LGLNFTKkevaqftckcerhigtqsggmdqaisimaqqgvaklidfnpvratdvqlpaggtfvianSLAESNkavtaatn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 177 -----------------SLPWD------KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 227
Cdd:PLN02521  262 ynnrvvecrlaaivlavKLGMSaeeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 228 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 301
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551226 302 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 373
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 11-373 3.16e-103

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 313.57  E-value: 3.16e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 164 LGMNLSK-----------------------------------------------------------LLAKSK-------- 176
Cdd:PLN02521  182 LGLNFTKkevaqftckcerhigtqsggmdqaisimaqqgvaklidfnpvratdvqlpaggtfvianSLAESNkavtaatn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 177 -----------------SLPWD------KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 227
Cdd:PLN02521  262 ynnrvvecrlaaivlavKLGMSaeeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 228 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 301
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551226 302 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 373
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
20-370 3.93e-62

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 203.85  E-value: 3.93e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  20 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD-FSTSAN 98
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  99 NVQIDKTKPlWHNYFLcG-FKGIQEHfGLsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKL-LAK-- 174
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVeLAKig 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 175 ----------------------SKSlpwDKVLRL-------EEVQarlrVSLEEM-LLITeD-----ALHPEPY-----S 214
Cdd:COG0153   155 qraenefvgvpcgimdqfasalGKK---GHALLLdcrsleyEYVP----LPLEGYaLVIV-DtnvkhSLADSEYnerraE 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 215 PEEVCSCLGIS---------LQELRTQILSPntqdvlifKLYQRAKHVYSEAARVLQFKKICEEapDNMvQLLGELMNQS 285
Cdd:COG0153   227 CEAAAAILGVKslrdvtledLEAARARLGDE--------VLRRRARHVVTENQRVLEAVEALRA--GDL-EAFGKLMNAS 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 286 HVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDRSLapekqSLFAT 364
Cdd:COG0153   296 HASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEP-----DFYVV 370


                  ....*.
gi 1333551226 365 KPGGGA 370
Cdd:COG0153   371 KPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-371 6.85e-57

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 190.42  E-value: 6.85e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  22 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTH--TLQLANTNPLYPDFSTsanN 99
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 100 VQIDKTKPL-WHNYFLCGFKGIQEHFGLSDLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVTltvlgMNLSKLLAKSKSL 178
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVL-----QNMGHLPLDSKQI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 179 pwdkVLRLEEV-------------QARLRVSLEEMLLITE-DALHPEPYS-PEevcscLGISL----------------- 226
Cdd:TIGR00131 153 ----LLRIQVAenhfvgvncgimdQAASVLGKEDHALLVEcRSLKATPFKfPQ-----LGIAFviantnvkrtlapsnyn 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 227 ---QELRTQIL------SPNTQDVLI--FKLY------------QRAKHVYSEAARVLQFKKICEeapDNMVQLLGELMN 283
Cdd:TIGR00131 224 trrQECTTAANflaatdKGALRDFMNeyFARYiarltkmlplveERAKHVVSENLRVLKAVKAMK---DNDFKQFGALMN 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 284 QSHVSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDrslAPEKQSLF 362
Cdd:TIGR00131 301 ESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTG---LELTFYVI 377


                  ....*....
gi 1333551226 363 ATKPGGGAL 371
Cdd:TIGR00131 378 VSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-75 9.94e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 9.94e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333551226  28 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEP 75
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 11-373 3.16e-103

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 313.57  E-value: 3.16e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 164 LGMNLSK-----------------------------------------------------------LLAKSK-------- 176
Cdd:PLN02521  182 LGLNFTKkevaqftckcerhigtqsggmdqaisimaqqgvaklidfnpvratdvqlpaggtfvianSLAESNkavtaatn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 177 -----------------SLPWD------KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 227
Cdd:PLN02521  262 ynnrvvecrlaaivlavKLGMSaeeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 228 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 301
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551226 302 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 373
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
20-370 3.93e-62

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 203.85  E-value: 3.93e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  20 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD-FSTSAN 98
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  99 NVQIDKTKPlWHNYFLcG-FKGIQEHfGLsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKL-LAK-- 174
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVeLAKig 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 175 ----------------------SKSlpwDKVLRL-------EEVQarlrVSLEEM-LLITeD-----ALHPEPY-----S 214
Cdd:COG0153   155 qraenefvgvpcgimdqfasalGKK---GHALLLdcrsleyEYVP----LPLEGYaLVIV-DtnvkhSLADSEYnerraE 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 215 PEEVCSCLGIS---------LQELRTQILSPntqdvlifKLYQRAKHVYSEAARVLQFKKICEEapDNMvQLLGELMNQS 285
Cdd:COG0153   227 CEAAAAILGVKslrdvtledLEAARARLGDE--------VLRRRARHVVTENQRVLEAVEALRA--GDL-EAFGKLMNAS 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 286 HVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDRSLapekqSLFAT 364
Cdd:COG0153   296 HASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEP-----DFYVV 370


                  ....*.
gi 1333551226 365 KPGGGA 370
Cdd:COG0153   371 KPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-371 6.85e-57

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 190.42  E-value: 6.85e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  22 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTH--TLQLANTNPLYPDFSTsanN 99
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 100 VQIDKTKPL-WHNYFLCGFKGIQEHFGLSDLtGMNCLVDGNIPPSSGLSSSSALVCCAGLVTltvlgMNLSKLLAKSKSL 178
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVL-----QNMGHLPLDSKQI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 179 pwdkVLRLEEV-------------QARLRVSLEEMLLITE-DALHPEPYS-PEevcscLGISL----------------- 226
Cdd:TIGR00131 153 ----LLRIQVAenhfvgvncgimdQAASVLGKEDHALLVEcRSLKATPFKfPQ-----LGIAFviantnvkrtlapsnyn 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 227 ---QELRTQIL------SPNTQDVLI--FKLY------------QRAKHVYSEAARVLQFKKICEeapDNMVQLLGELMN 283
Cdd:TIGR00131 224 trrQECTTAANflaatdKGALRDFMNeyFARYiarltkmlplveERAKHVVSENLRVLKAVKAMK---DNDFKQFGALMN 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 284 QSHVSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDrslAPEKQSLF 362
Cdd:TIGR00131 301 ESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTG---LELTFYVI 377


                  ....*....
gi 1333551226 363 ATKPGGGAL 371
Cdd:TIGR00131 378 VSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 23-346 3.08e-36

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 135.76  E-value: 3.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  23 KLKEMFNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD---FSTSA 97
Cdd:PRK05322    5 ELKKKFAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  98 NNVQIDKtKPLWHNYFLCGFKGIQEHfGLSDLTGMNCLVDGNIPPSsglssssalvccAGLVTLTVLGMNLSKLLAKSKS 177
Cdd:PRK05322   81 DDLSFDK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNG------------AGLSSSASIELLTGVILKDLFN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 178 LPWDkvlRLEEVQARLRVSLE---------------------EMLLITeDALHPEpYSP--------------------- 215
Cdd:PRK05322  147 LDLD---RLELVKLGQKTENEfigvnsgimdqfaigmgkkdhAILLDC-NTLEYE-YVPldlgdyvivimntnkrrelad 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 216 ----EEVCSClGISLQELRTQI-------LSPNTQD---VLIF--KLYQRAKHVYSEAARVLQFKKICEeapDNMVQLLG 279
Cdd:PRK05322  222 skynERRAEC-EKALEELQKKLdikslgeLTEEEFDeysYLIKdeTLLKRARHAVTENQRTLKAVKALK---AGDLEKFG 297

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1333551226 280 ELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAY 346
Cdd:PRK05322  298 RLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 23-350 2.04e-29

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 116.95  E-value: 2.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  23 KLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQL--ANTNPLYPDFSTSANnV 100
Cdd:PRK05101    6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViaADYDNQQDEFSLDAP-I 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 101 QIDKTKpLWHNYFLCGFKGIQEHfgLSDLTGMNCLVDGNIPPSsglssssalvccAGLVTLTVLGMNLSKLLAKSKSLPW 180
Cdd:PRK05101   85 VPHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQG------------AGLSSSASLEVAVGQTFQQLYHLPL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 181 DKV-LRLEEVQA-------------RLRVSLEE---MLLITEDALHPEPYS-PEEV------------------------ 218
Cdd:PRK05101  150 SGAeIALNGQEAenqfvgcncgimdQLISALGKkdhALLIDCRSLETKAVPmPEGVavviinsnvkrglvdseyntrrqq 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 219 CSC----LG------ISLQELRTQI--LSPntqdvlifKLYQRAKHVYSEAARVLQFKKICEEapDNMVqLLGELMNQSH 286
Cdd:PRK05101  230 CETaarfFGvkalrdVTLEQFNAVAaeLDP--------VVAKRARHVITENARTLEAASALAA--GDLK-RMGELMAESH 298

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551226 287 VSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQRS 350
Cdd:PRK05101  299 ASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 40-349 2.78e-29

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 115.86  E-value: 2.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  40 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDMLIAVEPV-KTHtlqlantnpLYPDFSTSANNVQIDKTKPL--WHNYFLC 115
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSeKFI---------FYSENFNEEKTFELDKLEKLnsWADYIKG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 116 GFKGIQEHFGlsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKLlakskslpwDKVLRLEEVQARL-- 193
Cdd:PRK03817   73 VIWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKL---------ELALLAREAENEFvg 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 194 ------------------RVSLEEMLLITEDALHPEPYS-----------------------PEEVCSCLGI-SLQELRT 231
Cdd:PRK03817  142 vpcgimdqfavafgkkdhAIFLDTMTLEYEYVPFPEDYEilvfdtgvkrelasseynerrqeCEEALKILGKkSSKEVTE 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 232 QILSPntqdvLIFKLYQRAKHVYSEAARVLQFKKICEEapdNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKFG 311
Cdd:PRK03817  222 EDLSK-----LPPLLRKRAGYVLRENERVLKVRDALKE---GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELG 293

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1333551226 312 AQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQR 349
Cdd:PRK03817  294 AYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-75 9.94e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 9.94e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333551226  28 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEP 75
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK00555 PRK00555
galactokinase; Provisional
 42-370 5.16e-18

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 84.53  E-value: 5.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226  42 APGRVNIIGEHIDY-CGYSvLPMAVEQDMLIAVEPVKTHTLQLANtnplypDFSTSANNVQIDkTKPL----WHNYFLCG 116
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 117 FKGIQEH------------------FGLSDLTGMNCLVDGNIPPSSGL----SSSSALVCCAGLVTL---TVLGMNLSKL 171
Cdd:PRK00555   79 IWALRGAghpvpggamsitsdveigSGLSSSAALECAVLGAVGAATGTridrLEQARLAQRAENEYVgapTGLLDQLAAL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 172 L-AKSKSLPWD-KVLRLEEVQARLRVSLEEMLLITEDALHPEP--------YSPEEVCSCLGI-SLQELRTQILSP--NT 238
Cdd:PRK00555  159 FgAPKTALLIDfRDLTVRPVAFDPDAAGVVLLLMDSRARHRHAggeyaarrASCERAAADLGVsSLRAVQDRGLAAlgAI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 239 QDVLIFKlyqRAKHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKFGAQGSRLT 318
Cdd:PRK00555  239 ADPIDAR---RARHVLTENQRVLDFAAALA---DSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMT 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1333551226 319 GAGWGGCTVSIVPADKLPSFLANVHEAYyqrsdRSLAPEKQSLFATKPGGGA 370
Cdd:PRK00555  313 GGGFGGCVIALVPADRAEDVADTVRRAA-----VTAGYPEPAVSRTYAAPGA 359
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 245-329 1.78e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 245 KLYQRAKHVYSEAARVLQfkkiceeapDNMVQLLGELMNQSHVSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 324
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1333551226 325 CTVSI 329
Cdd:PTZ00298  288 LVVAL 292
PLN02865 PLN02865
galactokinase
 246-372 6.02e-11

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 63.28  E-value: 6.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 246 LYQRAKHVYSEAARVLqfkKICEEAPDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGG 324
Cdd:PLN02865  296 LARRAEHYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRG 372

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1333551226 325 CTVSIVPADKLPSFLANVHEAYY--QRSDRSLAPEKQSLFATKPGGGALV 372
Cdd:PLN02865  373 CCVAFVDAEMAEEAASFVRDEYEkaQPELASNINGDKPVLICEAGDCARV 422
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 245-330 7.85e-10

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 59.09  E-value: 7.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 245 KLYQRAKHVYseAARVLQFKKICEEAPDNMVQ----LLGELMNQSHvscRDMYE--CSCPELDQLVDICRKFGAQGSRLT 318
Cdd:COG1577   191 KLKERNPELY--EAFLEEIGDLVEEAIEALEEgdleALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLT 265

                          90
                  ....*....|..
gi 1333551226 319 GAGWGGCTVSIV 330
Cdd:COG1577   266 GAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 242-327 2.18e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 57.69  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 242 LIFKLYQRAKHVYSEAARVLQfkkiceeapDNMVQLLGELMNQSHvSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAG 321
Cdd:TIGR00549 196 LIDSIMDAIGELTLEAKAALQ---------DGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAG 265


                  ....*.
gi 1333551226 322 WGGCTV 327
Cdd:TIGR00549 266 GGGCMI 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 268-348 2.98e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 53.24  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 268 EEAPDNMVQLLGELMNQSHVSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSIVP-ADKLPSFLANVHE 344
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1333551226 345 AYYQ 348
Cdd:pfam08544  82 AGKK 85
PRK03926 PRK03926
mevalonate kinase; Provisional
 278-334 7.37e-09

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 56.21  E-value: 7.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333551226 278 LGELMNQSHvSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADK 334
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
PTZ00290 PTZ00290
galactokinase; Provisional
 247-349 7.42e-09

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 57.14  E-value: 7.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 247 YQRAKHVYSEAARVLQFKKICEEA----PDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVD-ICRKFGAQGSRLTGAG 321
Cdd:PTZ00290  330 FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGG 409

                          90       100
                  ....*....|....*....|....*...
gi 1333551226 322 WGGCTVSIVPADKLPSFLANVHEAYYQR 349
Cdd:PTZ00290  410 FGGCIILLLKKNAVDRVVAHVREKFKAR 437
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 248-357 1.48e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 46.33  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551226 248 QRAKHVYSEAARVLQFKKICEEApDNMVQLL--------GELMNQSHVSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 318
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1333551226 319 GAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDRSLAPE 357
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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