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Conserved domains on  [gi|1333551223|ref|XP_023473473|]
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N-acetylgalactosamine kinase isoform X3 [Equus caballus]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 11-424 1.71e-141

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 413.33  E-value: 1.71e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 164 LGMNLSK---------------------------------AKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNKAATSH-- 208
Cdd:PLN02521  182 LGLNFTKkevaqftckcerhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 209 FNIRVMECRLAAKLLAKSKSLPWD----KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 278
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGMSAEeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 279 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 352
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551223 353 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 424
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 11-424 1.71e-141

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 413.33  E-value: 1.71e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 164 LGMNLSK---------------------------------AKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNKAATSH-- 208
Cdd:PLN02521  182 LGLNFTKkevaqftckcerhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 209 FNIRVMECRLAAKLLAKSKSLPWD----KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 278
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGMSAEeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 279 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 352
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551223 353 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 424
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
20-421 6.33e-70

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 225.81  E-value: 6.33e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  20 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD-FSTSAN 98
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  99 NVQIDKTKPlWHNYFLcG-FKGIQEHfGLsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKAKLIEFS 177
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 178 ----------------------------------PLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKL 222
Cdd:COG0153   155 qraenefvgvpcgimdqfasalgkkghallldcrSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 223 LAKskslpwdKVLRleevqarlRVSLEEmllitedalhpepyspeevcsclgisLQELRTQILSPntqdvlifKLYQRAK 302
Cdd:COG0153   234 LGV-------KSLR--------DVTLED--------------------------LEAARARLGDE--------VLRRRAR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 303 HVYSEAARVLQFKKICEEapDNMvQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIV 381
Cdd:COG0153   265 HVVTENQRVLEAVEALRA--GDL-EAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1333551223 382 PADKLPSFLANVHEAYYQRSDRSLapekqSLFATKPGGGA 421
Cdd:COG0153   342 PKDAVDEFIEAVAEAYAEKTGLEP-----DFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-422 1.18e-67

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 220.08  E-value: 1.18e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  22 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTH--TLQLANTNPLYPDFSTsanN 99
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 100 VQIDKTKPL-WHNYFLCGFKGIQEHFGLSDLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLG----------MNL 168
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGhlpldskqilLRI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 169 SKAK-------------------------LIEFSPLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKL 222
Cdd:TIGR00131 157 QVAEnhfvgvncgimdqaasvlgkedhalLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 223 LAKskslPWDKVLR--LEEVQARLRVSLEEMLLITEdalhpepyspeevcsclgislqelrtqilspntqdvlifklyQR 300
Cdd:TIGR00131 236 LAA----TDKGALRdfMNEYFARYIARLTKMLPLVE------------------------------------------ER 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 301 AKHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVS 379
Cdd:TIGR00131 270 AKHVVSENLRVLKAVKAMK---DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVH 346

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1333551223 380 IVPADKLPSFLANVHEAYYQRSDrslAPEKQSLFATKPGGGAL 422
Cdd:TIGR00131 347 LVPNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-75 1.53e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 1.53e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333551223  28 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEP 75
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 11-424 1.71e-141

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 413.33  E-value: 1.71e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  11 QLLEHvGYLRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHT-LQLANTNPL 89
Cdd:PLN02521   23 SLLEE-ARLRYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKkLRIANVNDK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  90 YPDFSTSANNVQ-IDKTKPLWHNYFLCGFKGIQEHFGLSD-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTV 163
Cdd:PLN02521  102 YTTCTFPADPDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 164 LGMNLSK---------------------------------AKLIEFSPLRATDVKLPSGAVFVIAHSCVEMNKAATSH-- 208
Cdd:PLN02521  182 LGLNFTKkevaqftckcerhigtqsggmdqaisimaqqgvAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 209 FNIRVMECRLAAKLLAKSKSLPWD----KVLRLEEVQArLRVSLEE------MLLITEDALHPEPYSPEEVCSCLGISLQ 278
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGMSAEeaisKVKTLSDVEG-LCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLT 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 279 ELRTQilSPNTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APDNMVQLLGELMNQSHVSCRDMYECSCPELD 352
Cdd:PLN02521  341 SIFKN--SPTSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELE 418

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1333551223 353 QLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQ-RSDRSLAPEKQ---SLFATKPGGGALVF 424
Cdd:PLN02521  419 ELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEKGVIKEEDlglYVFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
20-421 6.33e-70

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 225.81  E-value: 6.33e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  20 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD-FSTSAN 98
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  99 NVQIDKTKPlWHNYFLcG-FKGIQEHfGLsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKAKLIEFS 177
Cdd:COG0153    79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 178 ----------------------------------PLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKL 222
Cdd:COG0153   155 qraenefvgvpcgimdqfasalgkkghallldcrSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 223 LAKskslpwdKVLRleevqarlRVSLEEmllitedalhpepyspeevcsclgisLQELRTQILSPntqdvlifKLYQRAK 302
Cdd:COG0153   234 LGV-------KSLR--------DVTLED--------------------------LEAARARLGDE--------VLRRRAR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 303 HVYSEAARVLQFKKICEEapDNMvQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSIV 381
Cdd:COG0153   265 HVVTENQRVLEAVEALRA--GDL-EAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1333551223 382 PADKLPSFLANVHEAYYQRSDRSLapekqSLFATKPGGGA 421
Cdd:COG0153   342 PKDAVDEFIEAVAEAYAEKTGLEP-----DFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 22-422 1.18e-67

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 220.08  E-value: 1.18e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  22 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTH--TLQLANTNPLYPDFSTsanN 99
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKnvRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 100 VQIDKTKPL-WHNYFLCGFKGIQEHFGLSDLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLG----------MNL 168
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGhlpldskqilLRI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 169 SKAK-------------------------LIEFSPLRATDVKLP-SGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKL 222
Cdd:TIGR00131 157 QVAEnhfvgvncgimdqaasvlgkedhalLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 223 LAKskslPWDKVLR--LEEVQARLRVSLEEMLLITEdalhpepyspeevcsclgislqelrtqilspntqdvlifklyQR 300
Cdd:TIGR00131 236 LAA----TDKGALRdfMNEYFARYIARLTKMLPLVE------------------------------------------ER 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 301 AKHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVS 379
Cdd:TIGR00131 270 AKHVVSENLRVLKAVKAMK---DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVH 346

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1333551223 380 IVPADKLPSFLANVHEAYYQRSDrslAPEKQSLFATKPGGGAL 422
Cdd:TIGR00131 347 LVPNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 23-397 4.66e-38

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 141.92  E-value: 4.66e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  23 KLKEMFNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQLANTNplYPD---FSTSA 97
Cdd:PRK05322    5 ELKKKFAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  98 NNVQIDKtKPLWHNYFLCGFKGIQEHfGLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKAKLI--- 174
Cdd:PRK05322   81 DDLSFDK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVklg 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 175 --------------------------------------EFSPLRATDVKLpsgavfVIAHScvemNKA---ATSHFNIRV 213
Cdd:PRK05322  159 qktenefigvnsgimdqfaigmgkkdhailldcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 214 MECRLAakllakskslpwdkvlrLEEVQARLRV-SLEEmllITEDALhpepyspEEvcsclgisLQELrtqILSPNtqdv 292
Cdd:PRK05322  229 AECEKA-----------------LEELQKKLDIkSLGE---LTEEEF-------DE--------YSYL---IKDET---- 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 293 lifkLYQRAKHVYSEAARVLQFKKICEeapDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGA 371
Cdd:PRK05322  267 ----LLKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGA 339

                         410       420
                  ....*....|....*....|....*.
gi 1333551223 372 GWGGCTVSIVPADKLPSFLANVHEAY 397
Cdd:PRK05322  340 GFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 23-401 1.05e-36

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 138.13  E-value: 1.05e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  23 KLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHTLQL--ANTNPLYPDFSTSANnV 100
Cdd:PRK05101    6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViaADYDNQQDEFSLDAP-I 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 101 QIDKTKpLWHNYFLCGFKGIQEHfgLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKAK-------- 172
Cdd:PRK05101   85 VPHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEialngqea 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 173 --------------------------LIEFSPLRATDVKLPSGAVFVIAHSCVEMNkAATSHFNIRVMECRLAAKLLAKs 226
Cdd:PRK05101  162 enqfvgcncgimdqlisalgkkdhalLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFFGV- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 227 kslpwdKVLR---LEEVQARlrvsleemllitEDALHPEpyspeevcsclgislqelrtqilspntqdvlifkLYQRAKH 303
Cdd:PRK05101  240 ------KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKRARH 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 304 VYSEAARVLQFKKICEEapDNMVqLLGELMNQSHVSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSIV 381
Cdd:PRK05101  268 VITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALV 344

                         410       420
                  ....*....|....*....|
gi 1333551223 382 PADKLPSFLANVHEAYYQRS 401
Cdd:PRK05101  345 PEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 40-400 1.58e-32

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 125.88  E-value: 1.58e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  40 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDMLIAVEPV-KTHtlqlantnpLYPDFSTSANNVQIDKTKPL--WHNYFLC 115
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSeKFI---------FYSENFNEEKTFELDKLEKLnsWADYIKG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 116 GFKGIQEHFGlsDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKAKLI--------EF----------- 176
Cdd:PRK03817   73 VIWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELAllareaenEFvgvpcgimdqf 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 177 ---------------SPLRATDVKLPSGAVFVIAHSCVEmNKAATSHFNIRVMECRLAAKLLAKSKSlpwdkvlrlEEVq 241
Cdd:PRK03817  151 avafgkkdhaifldtMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSS---------KEV- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 242 arlrvsleemlliTEDALHpepyspeevcsclgiSLQELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEEa 321
Cdd:PRK03817  220 -------------TEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALKE- 254

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1333551223 322 pdNMVQLLGELMNQSHVSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYYQR 400
Cdd:PRK03817  255 --GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-75 1.53e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.12  E-value: 1.53e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1333551223  28 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEP 75
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK00555 PRK00555
galactokinase; Provisional
 42-421 3.55e-18

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 85.30  E-value: 3.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223  42 APGRVNIIGEHIDY-CGYSvLPMAVEQDMLIAVEPVKTHTLQLANtnplypDFSTSANNVQIDkTKPlwhnyflcgfkgi 120
Cdd:PRK00555    7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTP------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 121 qehfglSDLTGMNCLVDGNIppssglsssSALVCCA-----GLVTLTV---LGMNLSKAKLIEFSPLRAtdvklpsgavf 192
Cdd:PRK00555   66 ------GQVTGWAAYAAGVI---------WALRGAGhpvpgGAMSITSdveIGSGLSSSAALECAVLGA----------- 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 193 VIAHSCVEMNKAATShfniRVMEC--------------RLAAKLLAKSKSLPWD-KVLRLEEVQARLRVSLEEMLLITED 257
Cdd:PRK00555  120 VGAATGTRIDRLEQA----RLAQRaeneyvgaptglldQLAALFGAPKTALLIDfRDLTVRPVAFDPDAAGVVLLLMDSR 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 258 ALHPEP--------YSPEEVCSCLGI-SLQELRTQILSP--NTQDVLIFKlyqRAKHVYSEAARVLQFKKICEeapDNMV 326
Cdd:PRK00555  196 ARHRHAggeyaarrASCERAAADLGVsSLRAVQDRGLAAlgAIADPIDAR---RARHVLTENQRVLDFAAALA---DSDF 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 327 QLLGELMNQSHVSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYyqrsdRSLA 406
Cdd:PRK00555  270 TAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAA-----VTAG 344

                         410
                  ....*....|....*
gi 1333551223 407 PEKQSLFATKPGGGA 421
Cdd:PRK00555  345 YPEPAVSRTYAAPGA 359
PLN02865 PLN02865
galactokinase
 193-423 1.14e-12

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 69.06  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 193 VIAHSCVEMNKAATSHFNIRVMECRLAAKLLAKskslpwdkvlrleevqARLRVSLEEMLLITEdalhPEPYspeevcsc 272
Cdd:PLN02865  234 LLAFSGLRHALTNKPGYNLRVSECQEAARFLLE----------------ASGNDELEPLLCNVE----PEVY-------- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 273 lgislqELRTQILSPNtqdvlifkLYQRAKHVYSEAARVLqfkKICEEAPDNMVQLLGELMNQSHVSCRDMYECSCPELD 352
Cdd:PLN02865  286 ------EAHKCKLEAV--------LARRAEHYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLI 348

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1333551223 353 QLVDICRKF-GAQGSRLTGAGWGGCTVSIVPADKLPSFLANVHEAYY--QRSDRSLAPEKQSLFATKPGGGALV 423
Cdd:PLN02865  349 QLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEkaQPELASNINGDKPVLICEAGDCARV 422
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 296-380 2.60e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 296 KLYQRAKHVYSEAARVLQfkkiceeapDNMVQLLGELMNQSHVSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 375
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 1333551223 376 CTVSI 380
Cdd:PTZ00298  288 LVVAL 292
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 296-381 1.24e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 58.70  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 296 KLYQRAKHVYseAARVLQFKKICEEAPDNMVQ----LLGELMNQSHvscRDMYE--CSCPELDQLVDICRKFGAQGSRLT 369
Cdd:COG1577   191 KLKERNPELY--EAFLEEIGDLVEEAIEALEEgdleALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLT 265

                          90
                  ....*....|..
gi 1333551223 370 GAGWGGCTVSIV 381
Cdd:COG1577   266 GAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 293-378 2.73e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 57.69  E-value: 2.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 293 LIFKLYQRAKHVYSEAARVLQfkkiceeapDNMVQLLGELMNQSHvSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAG 372
Cdd:TIGR00549 196 LIDSIMDAIGELTLEAKAALQ---------DGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAG 265


                  ....*.
gi 1333551223 373 WGGCTV 378
Cdd:TIGR00549 266 GGGCMI 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 319-399 5.95e-09

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 52.86  E-value: 5.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 319 EEAPDNMVQLLGELMNQSHVSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSIVP-ADKLPSFLANVHE 395
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 1333551223 396 AYYQ 399
Cdd:pfam08544  82 AGKK 85
PRK03926 PRK03926
mevalonate kinase; Provisional
 329-385 9.28e-09

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 56.21  E-value: 9.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1333551223 329 LGELMNQSHvSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPADK 385
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
PTZ00290 PTZ00290
galactokinase; Provisional
 298-400 9.75e-09

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 57.14  E-value: 9.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 298 YQRAKHVYSEAARVLQFKKICEEA----PDNMVQLLGELMNQSHVSCRDMYECSCPELDQLVD-ICRKFGAQGSRLTGAG 372
Cdd:PTZ00290  330 FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGG 409

                          90       100
                  ....*....|....*....|....*...
gi 1333551223 373 WGGCTVSIVPADKLPSFLANVHEAYYQR 400
Cdd:PTZ00290  410 FGGCIILLLKKNAVDRVVAHVREKFKAR 437
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 299-408 1.83e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 46.33  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1333551223 299 QRAKHVYSEAARVLQFKKICEEApDNMVQLL--------GELMNQSHVSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 369
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1333551223 370 GAGWGGCTVSIVPADKLPSFLANVHEAYYQRSDRSLAPE 408
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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